Search of human proteins with 13449277

Search of human proteins with 13449277

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide
1 [Homo sapiens]
         (504 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...  1011   0.0  
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   479   e-135
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   478   e-135
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   470   e-132
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   455   e-128
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   440   e-123
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   421   e-117
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   420   e-117
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   416   e-116
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   409   e-114
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   381   e-106
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   374   e-103
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   357   2e-98
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   337   2e-92
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   324   1e-88
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   304   1e-82
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   285   7e-77
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   258   7e-69
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   255   8e-68
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   208   8e-54
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   207   2e-53
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   192   5e-49
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   177   3e-44
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  169   7e-42
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   161   1e-39
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   122   8e-28
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   120   4e-27
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   112   8e-25
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   109   7e-24
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   103   4e-22

>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score = 1011 bits (2615), Expect = 0.0
 Identities = 504/504 (100%), Positives = 504/504 (100%)

Query: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60
           MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL
Sbjct: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

Query: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120
           SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN
Sbjct: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

Query: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180
           GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN
Sbjct: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180

Query: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240
           VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH
Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

Query: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300
           VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL
Sbjct: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

Query: 301 FAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEA 360
           FAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEA
Sbjct: 301 FAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEA 360

Query: 361 QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDA 420
           QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDA
Sbjct: 361 QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDA 420

Query: 421 DGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSG 480
           DGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSG
Sbjct: 421 DGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSG 480

Query: 481 LFNIPPAFQLQVRPTDLHSTTQTR 504
           LFNIPPAFQLQVRPTDLHSTTQTR
Sbjct: 481 LFNIPPAFQLQVRPTDLHSTTQTR 504


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  479 bits (1233), Expect = e-135
 Identities = 238/489 (48%), Positives = 335/489 (68%), Gaps = 4/489 (0%)

Query: 8   ALLLALALL--LLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYG 65
           ++LL LALL  LLL L          LPPGP PLPLLGNLLQ+    L    +R  +KYG
Sbjct: 4   SVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYG 63

Query: 66  PVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWR 125
            VFT++LGP RPVV+L G EA+REAL  +AE FSGRG +AM++  F G+GV F+NG RW+
Sbjct: 64  DVFTVHLGP-RPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122

Query: 126 QLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSL 185
            LR+F++  +RD GMGKR  EE IQ EA+CL+E  + ++G   DP+ L    T+N++CS+
Sbjct: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182

Query: 186 LFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLA 245
           +FG RF Y+D+EF  ++     T   +SS  GQ +E+FS FL+  PG H+Q+  ++  + 
Sbjct: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242

Query: 246 AFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTM 305
           A+    V++H+  LD S P +DL+D +LL M +E+ N  +EF+++N+ +  + L FAGT 
Sbjct: 243 AYIGHSVEKHRETLDPSAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTE 301

Query: 306 TVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLA 365
           T STT+ Y  LL++KYPHV + V  E+ + +G  + P L DR ++PYT+AV++E QR   
Sbjct: 302 TTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSD 361

Query: 366 LVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFR 425
           L+PMG+P  + + T FRGY +P+ TEVF +L + LHDP+ F+ P+ FNPD FLDA+G  +
Sbjct: 362 LLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALK 421

Query: 426 KHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIP 485
           K EAF+PFSLGKR+CLGEG+A+AELFLFFTTILQ FS+ SP  P+ + L P   G+  IP
Sbjct: 422 KTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIP 481

Query: 486 PAFQLQVRP 494
           P +Q++  P
Sbjct: 482 PTYQIRFLP 490


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  478 bits (1230), Expect = e-135
 Identities = 239/485 (49%), Positives = 329/485 (67%), Gaps = 2/485 (0%)

Query: 10  LLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFT 69
           LLA   +++L       ++RG LPPGPTPLP +GN LQL    +Y+ LM++S++YGPVFT
Sbjct: 11  LLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFT 70

Query: 70  IYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRK 129
           I+LGP R VVVL G +AV+EAL  QAEEFSGRG  A  +  F G+GV FSNGER +QLR+
Sbjct: 71  IHLGP-RRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRR 129

Query: 130 FTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGL 189
           F++  LR  G+GKR  EE IQ EA  L++  +GT G   DP+  L++  SNV+ S++FG 
Sbjct: 130 FSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGD 189

Query: 190 RFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTV 249
           RF YEDKEF +++R   G+    ++  GQ YEMFS  ++ LPGP +Q    +  L  F  
Sbjct: 190 RFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIA 249

Query: 250 RQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVST 309
           ++V+ +Q  LD + P RD +D+FL++M +EE+NP TEF  KN++MT + L FAGT TVST
Sbjct: 250 KKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308

Query: 310 TVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPM 369
           T+ Y  LLLMK+P V+  V EE++R +G  + P   DR ++PYT+AV+HE QR   ++PM
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368

Query: 370 GIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEA 429
           G+   + + T+FR + LP+GTEVFP+LGS+L DP  F +P +FNP  FLD  G+F+K +A
Sbjct: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428

Query: 430 FLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQ 489
           F+PFS+GKR C GEGLA+ ELFLFFTTI+Q F  +SP  P  + + P   G   IP  + 
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488

Query: 490 LQVRP 494
           +   P
Sbjct: 489 MSFLP 493


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  470 bits (1209), Expect = e-132
 Identities = 235/487 (48%), Positives = 333/487 (68%), Gaps = 3/487 (0%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67
           ALL+ L +++L+++     +++G LPPGPTPLP +GN LQL    +Y+ LM++S++YGPV
Sbjct: 10  ALLVCLTVMVLMSV-WQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127
           FTI+LGP R VVVL G +AVREAL  QAEEFSGRG  A  +  F G+GV FSNGER +QL
Sbjct: 69  FTIHLGP-RRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127

Query: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187
           R+F++  LRD G+GKR  EE IQ EA  L++  +GT G   DP+  L++  SNV+ S++F
Sbjct: 128 RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVF 187

Query: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247
           G RF Y+DKEF +++R   G     S+  GQ YEMFS  ++ LPGP +Q    +  L  F
Sbjct: 188 GDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDF 247

Query: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307
             ++V+ +Q  LD + P RD +D+FL++M +EE+NP TEF  KN++MT + L   GT TV
Sbjct: 248 IAKKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETV 306

Query: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367
           STT+ Y  LLLMK+P V+  V EE++R +G  + P   DR ++PY +AV+HE QR   ++
Sbjct: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVI 366

Query: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427
           PM + R + + T+FR + LP+GTEV+P+LGS+L DP+ F +P++FNP  FL+  G+F+K 
Sbjct: 367 PMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS 426

Query: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487
           +AF+PFS+GKR C GEGLA+ ELFLFFTT++Q F L+S   P  + + P   G   IP  
Sbjct: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN 486

Query: 488 FQLQVRP 494
           + +   P
Sbjct: 487 YTMSFLP 493


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  455 bits (1171), Expect = e-128
 Identities = 233/487 (47%), Positives = 324/487 (66%), Gaps = 3/487 (0%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67
           ALL  L +++L+++     ++RG LPPGPTPLP +GN LQL    +   +M+ S+ YGPV
Sbjct: 10  ALLACLTVMVLMSV-WQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68

Query: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127
           FTI+LGP R VVVL G +AVREAL  QAEEFSGRG  A  +  F G+GV FSNGER +QL
Sbjct: 69  FTIHLGP-RRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQL 127

Query: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187
            +F +  LRD G+GKR  EE IQ E+  L+E  + T G   DP+  L++  SNV+ S++F
Sbjct: 128 LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 187

Query: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247
           G RF YEDKEF +++    G     S+  GQ YEMFS  ++ LPGP +Q    +  L  F
Sbjct: 188 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 247

Query: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307
             ++V+ +Q  LD + P +D +D+FL+ M +EE+NP TEF  KN++M+ + L  AGT TV
Sbjct: 248 IAKKVEHNQRTLDPNSP-QDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETV 306

Query: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367
           STT+ Y  LLLMK+P V+  V EE++R +G  + P   DRT++PY +AV+HE QR   ++
Sbjct: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVI 366

Query: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427
           PM + R + + T+FR + LP+GTEVFP+LGS+L DP+ F +P++FNP  FLD  G+F+K 
Sbjct: 367 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKS 426

Query: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487
           +AF+PFS+GKR C GEGLA+ ELFLFFTT++Q F L+S   P  + + P       IP  
Sbjct: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRN 486

Query: 488 FQLQVRP 494
           + +   P
Sbjct: 487 YTMSFLP 493


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  440 bits (1131), Expect = e-123
 Identities = 230/495 (46%), Positives = 324/495 (65%), Gaps = 6/495 (1%)

Query: 1   MEATGTWALLLALALL-LLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMR 59
           M++  T  LLL LAL+ LLLTL+   +R +G LPPGP PL +LGNLL L    + + L +
Sbjct: 1   MDSISTAILLLLLALVCLLLTLS---SRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTK 57

Query: 60  LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS 119
           LSK+YG ++T++LGP R VVVL G +AV+EAL  Q EEFSGRG          G+G+ FS
Sbjct: 58  LSKEYGSMYTVHLGP-RRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS 116

Query: 120 NGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATS 179
           +G+RW+ LR+F++  LR+ GMGKR  EE I  E   L+   + TEG PFDP+ +L+++ S
Sbjct: 117 SGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVS 176

Query: 180 NVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLH 239
           N++CS+LFG RF Y+D+    ++R        +SS  G+ Y++F   L  +PGPH+++  
Sbjct: 177 NIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQ 236

Query: 240 HVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYL 299
           +   L       V  HQ +LD   P RD +  FL KMA+E+++P + F    +LMT   L
Sbjct: 237 NFKCLRDLIAHSVHDHQASLDPRSP-RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNL 295

Query: 300 LFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHE 359
           LF GT TVSTT+ +  L LMKYP VQ  V+EE++  +G  + P+L DR  +PYTDAV+HE
Sbjct: 296 LFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHE 355

Query: 360 AQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419
            QR   ++PM +P  + R T FRG+ +P+GT+V  LL ++ +DP+ F  P+EFNP+ FLD
Sbjct: 356 VQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLD 415

Query: 420 ADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVS 479
           A+  F+K  AF+PFS G+R+CLGE LA+ ELFL+ T ILQ+FSL+    P+ + L P  S
Sbjct: 416 ANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSS 475

Query: 480 GLFNIPPAFQLQVRP 494
           GL N+P  FQL +RP
Sbjct: 476 GLGNLPRPFQLCLRP 490


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  421 bits (1081), Expect = e-117
 Identities = 215/482 (44%), Positives = 315/482 (65%), Gaps = 3/482 (0%)

Query: 9   LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVF 68
           L+L L+ LLLL+L    +  RG LPPGPTPLP++GN+LQ+    +   L  LSK YGPVF
Sbjct: 7   LVLCLSCLLLLSLWRQSS-GRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVF 65

Query: 69  TIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLR 128
           T+Y G  +P+VVL G EAV+EAL    EEFSGRG   + E    G G+ FSNG++W+++R
Sbjct: 66  TLYFG-LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIR 124

Query: 129 KFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFG 188
           +F+++ LR+ GMGKR  E+ +Q EARCLVE  + T+  P DP+ +L  A  NV+CS++F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFH 184

Query: 189 LRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFT 248
            RF Y+D++F  ++      +  +SS   Q    FS  +   PG H +LL +V+ + ++ 
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244

Query: 249 VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVS 308
           + +V++HQ ++D + P +D +D FL+KM +E+ N  +EFT +++  T + L  AGT T S
Sbjct: 245 LEKVKEHQESMDMNNP-QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303

Query: 309 TTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVP 368
           TT+ Y LLLL+K+P V   V+EE+ R +G  ++P + DR+ +PYTDAV+HE QR + L+P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363

Query: 369 MGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHE 428
             +P  +    +FR Y +P+GT +   L S+LHD   F +PE F+P  FLD  G F+K +
Sbjct: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423

Query: 429 AFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAF 488
            F+PFS GKR+C+GE LA  ELFLF T+ILQ F+L+S   P  L   P V+G  ++PP +
Sbjct: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483

Query: 489 QL 490
           QL
Sbjct: 484 QL 485


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  420 bits (1080), Expect = e-117
 Identities = 217/482 (45%), Positives = 313/482 (64%), Gaps = 3/482 (0%)

Query: 9   LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVF 68
           L+L L+ LLLL++    +  RG LPPGPTPLP++GN+LQ+    +   L  LSK YGPVF
Sbjct: 7   LVLCLSCLLLLSIWRQSS-GRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVF 65

Query: 69  TIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLR 128
           T+Y G  R +VVL G E V+EAL    EEFSGRG   + E    G G+ FSNG+RW+++R
Sbjct: 66  TLYFGLER-MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 129 KFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFG 188
           +F+++ LR+ GMGKR  E+ +Q EARCLVE  + T+  P DP+ +L  A  NV+CS++F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 189 LRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFT 248
            RF Y+D++F  ++      +  VS+   Q    F   +   PG H +LL +++ + +  
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 249 VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVS 308
           + +V++HQ ++D + P RD +D FL+KM +E+QN  +EFT +N+++T   LL AGT T S
Sbjct: 245 LEKVKEHQESMDINNP-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303

Query: 309 TTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVP 368
           TT+ Y LLLL+K+P V   V+EE+ R +G  ++P + DR  +PYTDAV+HE QR + L+P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363

Query: 369 MGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHE 428
             +P  +    +FR Y +P+GT +   L S+LHD   F +PE F+P  FLD  G F+K  
Sbjct: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423

Query: 429 AFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAF 488
            F+PFS GKR+C+GEGLA+ ELFLF T ILQ F+L+S   P  L   P V+G  ++PP +
Sbjct: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFY 483

Query: 489 QL 490
           QL
Sbjct: 484 QL 485


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  416 bits (1069), Expect = e-116
 Identities = 212/483 (43%), Positives = 309/483 (63%), Gaps = 3/483 (0%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67
           AL+L L+ L LL+L    +  RG LP GPTPLP++GN+LQL    +   L   SK YGPV
Sbjct: 6   ALVLCLSCLFLLSLWRQSS-GRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127
           FT+Y G  +P+VVL G EAV+EAL    EEFSGRG+  + E    G G+ FSNG+RW+++
Sbjct: 65  FTVYFG-LKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123

Query: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187
           R+F ++ LR+ GMGKR  E+ +Q EARCLVE  + T   P DP+ +L  A  NV+CS++F
Sbjct: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183

Query: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247
             RF Y+D+ F  ++      L  +SS   Q    F   +  LPG H ++  + + + ++
Sbjct: 184 HDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307
            + ++++HQ +LD +  ARD +D FL+KM QE+ N  +EFT ++++ TV  +  AGT T 
Sbjct: 244 VLERIKEHQESLDMNS-ARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETT 302

Query: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367
           STT+ Y LLLL+KYP V   V+EE+   +G  ++P + DR+ +PYTDAV+HE QR + L+
Sbjct: 303 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 362

Query: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427
           P  +P  +    +F+ Y +P+GT +   L S+LH+   F +PE F+P  FLD  G F+K 
Sbjct: 363 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 422

Query: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487
           + F+PFS GKR+C+GEGLA+ ELFLF TTILQ F+L+S   P  + + P  +    +PP 
Sbjct: 423 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPL 482

Query: 488 FQL 490
           +QL
Sbjct: 483 YQL 485


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  409 bits (1050), Expect = e-114
 Identities = 209/482 (43%), Positives = 304/482 (63%), Gaps = 3/482 (0%)

Query: 9   LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVF 68
           L+L L+ +LL +L     R R  LPPGPTPLP++GN+LQ+    +       SK YGPVF
Sbjct: 7   LVLCLSFMLLFSLWRQSCRRR-KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVF 65

Query: 69  TIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLR 128
           T+Y G   P+VV  G EAV+EAL    EEFSGRG   + +    G G+  SNG+RW+++R
Sbjct: 66  TVYFG-MNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124

Query: 129 KFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFG 188
           +F++  LR+ GMGKR  E+ +Q EA CLVE  + T+  P DP+ +L  A  NV+CS++F 
Sbjct: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184

Query: 189 LRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFT 248
            RF Y+D+ F  +++        ++S   Q    F   +   PG H ++L +V+   ++ 
Sbjct: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244

Query: 249 VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVS 308
             +V++HQ +LD + P RD +D FL+KM QE+ N  +EF  +N++ TV  L  AGT T S
Sbjct: 245 REKVKEHQASLDVNNP-RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTS 303

Query: 309 TTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVP 368
           TT+ Y LLLL+K+P V   V+EE++  +G  ++P + DR+ +PYTDAV+HE QR   LVP
Sbjct: 304 TTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVP 363

Query: 369 MGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHE 428
            G+P  +   T+FR Y +P+GT +  LL S+LHD   F +P  F+P  FLD +G F+K +
Sbjct: 364 TGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSD 423

Query: 429 AFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAF 488
            F+PFS GKR+C GEGLA+ ELFLF TTILQ F+L+S      L+      G+ ++PP++
Sbjct: 424 YFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSY 483

Query: 489 QL 490
           Q+
Sbjct: 484 QI 485


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  381 bits (978), Expect = e-106
 Identities = 203/494 (41%), Positives = 297/494 (60%), Gaps = 3/494 (0%)

Query: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60
           M A G    LL  A  LLL        +  +LPPGP PLP++GNL QL    +     RL
Sbjct: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

Query: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120
           ++++GPVFT+Y+G  R +VV+ G +AV+EAL    +EFSGRG +       D  G+ F+N
Sbjct: 61  AQRFGPVFTLYVGSQR-MVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD-RGIIFNN 118

Query: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180
           G  W+ +R+F++  LR+ GMGK+  E  IQ EA  L+E  + T+G+PFDP+ L+  A  N
Sbjct: 119 GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCN 178

Query: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240
           V+  +LF   F Y D++F  ++         +S+   Q Y  F  FL  LPG H++++ +
Sbjct: 179 VIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKN 238

Query: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300
           V+ +  +   +V++H  +LD + P RDL D  L++M +E+ +    +T   + +TV  L 
Sbjct: 239 VAEVKEYVSERVKEHHQSLDPNCP-RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLF 297

Query: 301 FAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEA 360
           FAGT T STT+ Y LL+LMKYP +++ + EE++R +G  + P++ DR  +PY DAV+HE 
Sbjct: 298 FAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEI 357

Query: 361 QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDA 420
           QR + LVP  +P    R T FRGY +P+GT V P L S+L+D   F  PE+F P+ FL+ 
Sbjct: 358 QRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNE 417

Query: 421 DGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSG 480
           +G+F+  + F PFS GKRVC GEGLA+ ELFL    ILQ F+L+    P  + L P   G
Sbjct: 418 NGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIG 477

Query: 481 LFNIPPAFQLQVRP 494
              IPP ++L V P
Sbjct: 478 FGCIPPRYKLCVIP 491


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  374 bits (959), Expect = e-103
 Identities = 199/487 (40%), Positives = 287/487 (58%), Gaps = 54/487 (11%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67
           ALL  L +++L+++     ++RG LPPGPTPLP +GN LQL    +   +M++S+     
Sbjct: 10  ALLACLTVMVLMSV-WQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63

Query: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127
                                                          GV FSNGER +QL
Sbjct: 64  -----------------------------------------------GVAFSNGERAKQL 76

Query: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187
            +F +  LRD G+GKR  EE IQ E+  L+E  + T G   DP+  L++  SNV+ S++F
Sbjct: 77  LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 136

Query: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247
           G RF YEDKEF +++    G     S+  GQ YEMFS  ++ LPGP +Q    +  L  F
Sbjct: 137 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 196

Query: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307
             ++V+ +Q  LD + P +D +D+FL+ M +EE+NP TEF  KN++M+ + L  AGT TV
Sbjct: 197 IAKKVEHNQRTLDPNSP-QDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETV 255

Query: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367
           STT+ Y  LLLMK+P V+  V EE++R +G  + P   DRT++PY +AV+HE QR   ++
Sbjct: 256 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVI 315

Query: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427
           PM + R + + T+FR + LP+GTEVFP+LGS+L DP+ F +P++FNP  FLD  G+F+K 
Sbjct: 316 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKS 375

Query: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487
           +AF+PFS+GKR C GEGLA+ ELFLFFTT++Q F L+S   P  + + P       IP  
Sbjct: 376 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRN 435

Query: 488 FQLQVRP 494
           + +   P
Sbjct: 436 YTMSFLP 442


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  357 bits (915), Expect = 2e-98
 Identities = 197/483 (40%), Positives = 277/483 (57%), Gaps = 62/483 (12%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67
           AL+L L+ L LL+L    +  RG LP GPTPLP++GN+LQL    +   L   SK YGPV
Sbjct: 6   ALVLCLSCLFLLSLWRQSS-GRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127
           FT+Y G  +P+VVL G EAV+EAL    EEFSGRG+  + E    G G+ FSNG+RW+++
Sbjct: 65  FTVYFG-LKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123

Query: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187
           R+F ++ LR+ GMGKR  E+ +Q EARCLVE  + T   P DP+ +L  A  NV+CS++F
Sbjct: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183

Query: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247
             RF Y+D+ F  ++                  E F+  LR L  P  Q           
Sbjct: 184 HDRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ----------- 214

Query: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307
                                          E+ N  +EFT ++++ TV  +  AGT T 
Sbjct: 215 -------------------------------EKHNQQSEFTVESLIATVTDMFGAGTETT 243

Query: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367
           STT+ Y LLLL+KYP V   V+EE+   +G  ++P + DR+ +PYTDAV+HE QR + L+
Sbjct: 244 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 303

Query: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427
           P  +P  +    +F+ Y +P+GT +   L S+LH+   F +PE F+P  FLD  G F+K 
Sbjct: 304 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 363

Query: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487
           + F+PFS GKR+C+GEGLA+ ELFLF TTILQ F+L+S   P  + + P  +    +PP 
Sbjct: 364 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPL 423

Query: 488 FQL 490
           +QL
Sbjct: 424 YQL 426


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  337 bits (864), Expect = 2e-92
 Identities = 181/478 (37%), Positives = 278/478 (58%), Gaps = 9/478 (1%)

Query: 3   ATGTWALLLALALLL-----LLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGL 57
           A   WA++    LLL     LL       R   + PPGP  LP LGN   +     +  +
Sbjct: 9   AAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEV 68

Query: 58  MRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVF 117
               KKYG +F++ LG    V++  G   ++EAL    + F  R    M E  F  +G+ 
Sbjct: 69  QLFVKKYGNLFSLELGDISAVLI-TGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLI 127

Query: 118 FSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQA 177
            S+G+ W++ R+FT+ ALR+ G+GK+  EE IQ EA+ L E  +   G+PFDP   +  A
Sbjct: 128 MSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNA 187

Query: 178 TSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQL 237
            SN++CS+ FG RF Y+D  FQ +++         +S+  Q Y +F W ++ LPGPH+ L
Sbjct: 188 VSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247

Query: 238 LHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVI 297
             +   L  F    + +H+ + + +   RD +DA+L +M++   NP + F  +N++ + +
Sbjct: 248 FSNWKKLKLFVSHMIDKHRKDWNPA-ETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTL 306

Query: 298 YLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVL 357
            L FAGT T STT+ + LL +  YP +Q+ V+ E++R +G GQ PS   R  +PYT+AV+
Sbjct: 307 DLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVI 366

Query: 358 HEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRF 417
           HE QR+  ++P+ +PR +   T   GY LP+GT +   L ++  DP  +  P+ FNPD F
Sbjct: 367 HEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHF 426

Query: 418 LDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLK 475
           L+ +G+F+K EAF+PFS+GKR CLGE LA+ ELF+FFT+++Q F+   P   + LSLK
Sbjct: 427 LE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPP-NNEKLSLK 482


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  324 bits (830), Expect = 1e-88
 Identities = 198/488 (40%), Positives = 273/488 (55%), Gaps = 17/488 (3%)

Query: 13  LALLLLLTLALSGT-----------RARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLS 61
           +ALLLLL L L G                  PPGP PLPL+GNL  LR       LM LS
Sbjct: 1   MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELS 60

Query: 62  KKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNG 121
           ++YGPVFT++LG  +  VVL G EAV+EAL G  +E + R  +A+ +    G G+FFS+G
Sbjct: 61  ERYGPVFTVHLGRQK-TVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSG 119

Query: 122 ERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNV 181
            RWR  R+FT+ AL  LG+G+    + I  E +CL     G  GRPF P  LL  A SN+
Sbjct: 120 ARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNI 178

Query: 182 VCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHV 241
             +LLFG RF Y D  F +++      ++ + S G Q + ++ W L  L   H+ +L  +
Sbjct: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPW-LGALLQLHRPVLRKI 237

Query: 242 STLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLF 301
             + A     ++  + ++    P    VDA L++  Q +   G  F   N +   + ++ 
Sbjct: 238 EEVRAILRTLLEARRPHVCPGDPVCSYVDA-LIQQGQGDDPEGL-FAEANAVACTLDMVM 295

Query: 302 AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQ 361
           AGT T S T+ +  LL+ ++P VQ  V+EEL+R LG G+ P L D+  LPYT AVLHE Q
Sbjct: 296 AGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQ 355

Query: 362 RLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDAD 421
           R + L+P  +PR     T+  G+ LP+GT V PLL S+L D   ++ P +FNP  FLDA+
Sbjct: 356 RFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDAN 414

Query: 422 GRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGL 481
           G F K EAFLPFS G+RVC+GE LA+ ELFL F  +LQ + L  P      SL  T +  
Sbjct: 415 GHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARA 474

Query: 482 FNIPPAFQ 489
           F + P  Q
Sbjct: 475 FTMRPRAQ 482


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  304 bits (778), Expect = 1e-82
 Identities = 189/503 (37%), Positives = 282/503 (56%), Gaps = 19/503 (3%)

Query: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60
           +EA    A+++A+  LLL+ L     R     PPGP PLP LGNLL +          +L
Sbjct: 3   LEALVPLAVIVAI-FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 61

Query: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDG---HGVF 117
            +++G VF++ L  W PVVVL G  AVREAL    E+ + R  V + +    G    GVF
Sbjct: 62  RRRFGDVFSLQLA-WTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

Query: 118 FSN-GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQ 176
            +  G  WR+ R+F++  LR+LG+GK+  E+ +  EA CL   F    GRPF P+ LL +
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

Query: 177 ATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPH 234
           A SNV+ SL  G RF Y+D  F  ++  A     G+  + G   E+ +    L  +P   
Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQE---GLKEESGFLREVLNAVPVLLHIPALA 237

Query: 235 KQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLM 294
            ++L             + +H+   D + P RDL +AFL +M + + NP + F ++N+ +
Sbjct: 238 GKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCI 297

Query: 295 TVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTD 354
            V  L  AG +T STT+ + LLL++ +P VQ+ V++E++  +G  + P +GD+  +PYT 
Sbjct: 298 VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTT 357

Query: 355 AVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNP 414
           AV+HE QR   +VP+G+     R    +G+ +P+GT +   L S+L D  +++ P  F+P
Sbjct: 358 AVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHP 417

Query: 415 DRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSL 474
           + FLDA G F K EAFLPFS G+R CLGE LA+ ELFLFFT++LQ FS   P    T   
Sbjct: 418 EHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP----TGQP 473

Query: 475 KPTVSGLFNIPPAFQLQVRPTDL 497
           +P+  G+F    AF +   P +L
Sbjct: 474 RPSHHGVF----AFLVTPSPYEL 492


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  285 bits (729), Expect = 7e-77
 Identities = 186/502 (37%), Positives = 269/502 (53%), Gaps = 32/502 (6%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQ------LRPGALYSG----- 56
           ALLL   + LL    L   RARG +PPGPTP PL+GN         LR  +  S      
Sbjct: 36  ALLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAA 94

Query: 57  ------------LMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTV 104
                       L  L++ YG +F+ ++G +  VVVL    +VREAL  QAE FS R  V
Sbjct: 95  GIDPSVIGPQVLLAHLARVYGSIFSFFIGHYL-VVVLSDFHSVREALVQQAEVFSDRPRV 153

Query: 105 AMLEGTFDGHGVFFSN-GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGT 163
            ++       GV F++ G  WRQ RKF+   LR  G+GK   E  I  E + +    Q  
Sbjct: 154 PLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKH 213

Query: 164 EGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMF 223
              PF P  +++ A SN++CSL FG RF Y + EF+ ++      L    +       + 
Sbjct: 214 GEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNIC 273

Query: 224 SWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNP 283
            W      GP K+L      + +F  + ++ HQ +LD   P +D +D +LL M +E +N 
Sbjct: 274 PWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENP-QDFIDMYLLHMEEERKNN 332

Query: 284 GTEFTNKNMLMTVIYLLF-AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAP 342
                ++  L  +I  LF AGT T + ++ + LL +   P VQ+ V EE+ R +GA +AP
Sbjct: 333 SNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAP 392

Query: 343 SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHD 402
           SL D+ ++PYT+A + E QRL  +VP+ IP      T  +GYT+P+GT + P L S+  D
Sbjct: 393 SLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRD 452

Query: 403 PNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS 462
           P I++ PE+F P+RFLD  G+  K E F+PF +GKRVC+GE LAK ELFL F +++Q+F+
Sbjct: 453 PAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFA 512

Query: 463 LESPCPPDTLSLKPTVSGLFNI 484
              P      S KP ++G F +
Sbjct: 513 FALP----EDSKKPLLTGRFGL 530


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  258 bits (660), Expect = 7e-69
 Identities = 164/469 (34%), Positives = 253/469 (53%), Gaps = 11/469 (2%)

Query: 5   GTWALLLALALLLL---LTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGAL--YSGLMR 59
           G  AL  AL LLL    +   L   R  G  PPGP  LP +GN+  L   +   +  + +
Sbjct: 10  GAAALGGALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRK 68

Query: 60  LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS 119
            S+ YG +F++ LG     VVL G + V+E L  Q+E F+ R  + +        G+  S
Sbjct: 69  QSQVYGEIFSLDLGGIS-TVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNS 127

Query: 120 N-GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQAT 178
             G  W   R+  + + R  G G++  E  I  E +   +  +  +GRPFD   L+  A 
Sbjct: 128 RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAV 187

Query: 179 SNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLP-GPHKQL 237
           SN+   ++FG RF+YED +FQ ++      +   +S     Y  F W +  LP G H+QL
Sbjct: 188 SNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPW-IGILPFGKHQQL 246

Query: 238 LHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVI 297
             + + +  F  R +++   N     P +  VDA+L +M Q + +P + F+ +N++ +V 
Sbjct: 247 FRNAAVVYDFLSRLIEKASVNRKPQLP-QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVG 305

Query: 298 YLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVL 357
            L+ AGT T +  + + +L +  YP++Q  V++E++  +G    PS  D+ ++PYT+AVL
Sbjct: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365

Query: 358 HEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRF 417
           HE  R   +VP+GI          RGY++P+GT V   L S+  D   ++ PE F+P+RF
Sbjct: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425

Query: 418 LDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESP 466
           LD+ G F K EA +PFSLG+R CLGE LA+ E+FLFFT +LQ F L  P
Sbjct: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  255 bits (651), Expect = 8e-68
 Identities = 172/499 (34%), Positives = 257/499 (51%), Gaps = 62/499 (12%)

Query: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60
           +EA    A+++A+  LLL+ L     R     PPGP PLP LGNLL +          +L
Sbjct: 3   LEALVPLAVIVAI-FLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL 61

Query: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120
            +++G VF++ L  W PVVVL G  AVREAL    E+ + R  V + +            
Sbjct: 62  RRRFGDVFSLQLA-WTPVVVLNGLAAVREALVTHGEDTADRPPVPITQ------------ 108

Query: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180
                            LG G R                   ++GRPF P+ LL +A SN
Sbjct: 109 ----------------ILGFGPR-------------------SQGRPFRPNGLLDKAVSN 133

Query: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWF--LRPLPGPHKQLL 238
           V+ SL  G RF Y+D  F  ++  A     G+  + G   E+ +    L  +P    ++L
Sbjct: 134 VIASLTCGRRFEYDDPRFLRLLDLAQE---GLKEESGFLREVLNAVPVLLHIPALAGKVL 190

Query: 239 HHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIY 298
                        + +H+   D + P RDL +AFL +M + + NP + F ++N+ + V  
Sbjct: 191 RFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVAD 250

Query: 299 LLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLH 358
           L  AG +T STT+ + LLL++ +P VQ+ V++E++  +G  + P +GD+  +PYT AV+H
Sbjct: 251 LFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH 310

Query: 359 EAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFL 418
           E QR   +VP+G+     R    +G+ +P+GT +   L S+L D  +++ P  F+P+ FL
Sbjct: 311 EVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL 370

Query: 419 DADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTV 478
           DA G F K EAFLPFS G+R CLGE LA+ ELFLFFT++LQ FS   P    T   +P+ 
Sbjct: 371 DAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP----TGQPRPSH 426

Query: 479 SGLFNIPPAFQLQVRPTDL 497
            G+F    AF +   P +L
Sbjct: 427 HGVF----AFLVTPSPYEL 441


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  208 bits (530), Expect = 8e-54
 Identities = 150/470 (31%), Positives = 234/470 (49%), Gaps = 26/470 (5%)

Query: 9   LLLALALLLLLTLALSGTRARGH----LPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKY 64
           LLL L++L  + +     R R       PPGP   PL+GN   +   A  S   RL+++Y
Sbjct: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLS-FARLARRY 81

Query: 65  GPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN-GER 123
           G VF I LG   P+VVL G+ A+ +AL  Q   F+ R   A       G  + F +  E 
Sbjct: 82  GDVFQIRLGSC-PIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140

Query: 124 WRQLRKFTMLALRDLGMGKREGEELIQ----AEARCLVETFQ--GTEGRPFDPSLLLAQA 177
           W+  R+     +R+    +    ++++    +EAR LV        +G   DP  L   A
Sbjct: 141 WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVA 200

Query: 178 TSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQL 237
            +NV+ ++ FG R+S++D EF+ ++  +     G +   G   ++  W L+  P P + +
Sbjct: 201 VANVMSAVCFGCRYSHDDPEFRELL--SHNEEFGRTVGAGSLVDVMPW-LQYFPNPVRTV 257

Query: 238 LHHVSTL----AAFTVRQVQQHQGNLDASGPARDLVDAFLL----KMAQEEQNPGTEFTN 289
                 L    + F + +  +H  +L      RD++DAF+L    K A +    G     
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 290 KNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTR 349
           +N+  T+  +  A   T+ST + + LLL  +YP VQ  V+ EL++ +G  + P +GD+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 350 LPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHP 409
           LPY  A L+EA R  + VP+ IP      T   GY +P+ T VF    S+ HDP  + +P
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437

Query: 410 EEFNPDRFLDADGRFRKH--EAFLPFSLGKRVCLGEGLAKAELFLFFTTI 457
           E F+P RFLD DG   K      + FS+GKR C+GE L+K +LFLF + +
Sbjct: 438 ENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 487


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  207 bits (527), Expect = 2e-53
 Identities = 147/486 (30%), Positives = 243/486 (50%), Gaps = 39/486 (8%)

Query: 33  PPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALG 92
           PPGP   PL+G++L L     +  L R+S++YG V  I +G   PVVVL G + +R+AL 
Sbjct: 40  PPGPWGWPLIGHMLTLGKNP-HLALSRMSQQYGDVLQIRIGS-TPVVVLSGLDTIRQALV 97

Query: 93  GQAEEFSGRGTVAMLEGTFDGHGVFFS--NGERWRQLRKFTMLALRDLGMGKREG----- 145
            Q ++F GR  +       +G  + FS  +G  W   R+     L+   +          
Sbjct: 98  RQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSC 157

Query: 146 --EELIQAEARCLVETFQGTEGRP--FDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAV 201
             EE +  EA  L+ T Q     P  F+P   +  + +NV+C++ FG R+ +  +E  ++
Sbjct: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217

Query: 202 VRAAG--GTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-LAAFTVRQVQQHQGN 258
           V      G ++G  +        F   LR LP P       ++    +F  + V++H   
Sbjct: 218 VNLNNNFGEVVGSGNPAD-----FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT 272

Query: 259 LDASGPARDLVDAFLLKMAQEEQ---NPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTL 315
            +  G  RD+ D+ L++  QE+Q   N   + +++ ++  V+ L  AG  TV+T + ++L
Sbjct: 273 FE-KGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330

Query: 316 LLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTL 375
           + L+  P VQ+ ++EEL+  +G  + P L DR+ LPY +A + E  R  + VP  IP + 
Sbjct: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390

Query: 376 MRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRK--HEAFLPF 433
            R T  +G+ +P+G  VF     I HD  ++ +P EF P+RFL  DG   K   E  + F
Sbjct: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450

Query: 434 SLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIP------PA 487
            +GKR C+GE +A+ E+FLF   +LQ      P     L +K  ++ ++ +         
Sbjct: 451 GMGKRKCIGETIARWEVFLFLAILLQRVEFSVP-----LGVKVDMTPIYGLTMKHACCEH 505

Query: 488 FQLQVR 493
           FQ+Q+R
Sbjct: 506 FQMQLR 511


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  192 bits (489), Expect = 5e-49
 Identities = 149/480 (31%), Positives = 228/480 (47%), Gaps = 27/480 (5%)

Query: 9   LLLALALLLLLTLALSGTRARG----HLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKY 64
           LLLA A+  L+   L G R R       PP P   PLLG++L L     +  L R+S++Y
Sbjct: 14  LLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNP-HLALSRMSQRY 72

Query: 65  GPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS--NGE 122
           G V  I +G   PV+VL   + +R+AL  Q ++F GR  +       DG  + FS  +G 
Sbjct: 73  GDVLQIRIGS-TPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGP 131

Query: 123 RWRQLRKFTMLALRDLGMGKREG-------EELIQAEARCLVETFQGTEGRP--FDPSLL 173
            W   R+    AL    +            EE +  EA+ L+   Q     P  FDP   
Sbjct: 132 VWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQ 191

Query: 174 LAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGP 233
           +  + +NV+ ++ FG  F     E  ++V+     +   SS  G   + F   LR LP P
Sbjct: 192 VVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFP-ILRYLPNP 248

Query: 234 HKQLLHHVST-LAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNM 292
             Q     +     F  + VQ+H  + D +   RD+  A      +  +  G     + +
Sbjct: 249 ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNS-VRDITGALFKHSKKGPRASGNLIPQEKI 307

Query: 293 LMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPY 352
           +  V  +  AG  TV+T + ++L+ L+  P +Q+ +++EL+  +G  + P L DR +LPY
Sbjct: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367

Query: 353 TDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEF 412
            +A + E  R  + +P  IP +  R T   G+ +P+   VF     + HDP +++ P EF
Sbjct: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427

Query: 413 NPDRFLDADGRFRK---HEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPP 469
            P+RFL ADG        E  + F +GKR C+GE LAK E+FLF   +LQ   LE   PP
Sbjct: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ--QLEFSVPP 485


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  177 bits (448), Expect = 3e-44
 Identities = 157/518 (30%), Positives = 252/518 (48%), Gaps = 46/518 (8%)

Query: 10  LLALALLLLLTLALSGTRARG--------HLPPGPTPLPLLGNLLQLRPGALYSGLMRLS 61
           +L L LLLLL L L+G R           HLPP      L    L L    L   L+ L+
Sbjct: 1   MLLLGLLLLLPL-LAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLT 53

Query: 62  KKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRG---TVAMLEGTFDGHGVFF 118
           +K+GP++ ++LG  + VVVL  +  + EA+  +  +F+GR    T  ++   +       
Sbjct: 54  QKFGPIYRLHLG-LQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPD----L 108

Query: 119 SNGER---WRQLRKFTMLALRDLGMGKREG-EELIQAEARCLVETFQGTEGRPFDPSLLL 174
           S G+    W+  +K T  AL    +G R+  E +++   +   E  +   G P       
Sbjct: 109 SLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEF 165

Query: 175 AQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPH 234
           +  T +++C L FG +   +D    A  +     L   S    Q  ++   FLR  P P 
Sbjct: 166 SLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPG 223

Query: 235 -KQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGT-EFTNKNM 292
            ++L   +         Q++QH+ +L A G  RD++D  L  +AQ     G+ +    ++
Sbjct: 224 LRRLKQAIEKRDHIVEMQLRQHKESLVA-GQWRDMMDYMLQGVAQPSMEEGSGQLLEGHV 282

Query: 293 LMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS---LGDRTR 349
            M  + LL  GT T + T+ + ++ L+ +P +Q+ ++EEL+ ELG G + S     DR R
Sbjct: 283 HMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRAR 342

Query: 350 LPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHP 409
           LP  +A + E  RL  +VP+ +P    R +   GY +P+GT + P L     D  +++ P
Sbjct: 343 LPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERP 402

Query: 410 EEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS-LESPCP 468
            EF PDRFL+      K+   L F  G RVCLGE LA+ ELF+  T +LQAF+ L S   
Sbjct: 403 HEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDA 458

Query: 469 PDTLSLKPTVSGLFNIPPAFQLQVRPTDL--HSTTQTR 504
             +L   P  S +  + P FQ++++P  +  HS  Q++
Sbjct: 459 LPSLQPLPHCSVILKMQP-FQVRLQPRGMGAHSPGQSQ 495


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  169 bits (427), Expect = 7e-42
 Identities = 135/496 (27%), Positives = 239/496 (48%), Gaps = 17/496 (3%)

Query: 10  LLALALLLLLTLALSGTRARG-HLPPGPTPLPLLGNLLQL-RPGALYSGLMRLSKKYGPV 67
           L+AL LL L  L     R  G   P     LPL+G+L  L R G +++   +L KKYGP+
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63

Query: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLE-GTFDGHGVFFSN-GERWR 125
           +++ +G  +  V++   +  +E L  + ++FSGR  +A L+  + +  G+ F++ G  W+
Sbjct: 64  YSVRMGT-KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQ 122

Query: 126 QLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSL 185
             R+  M        G ++ E++I  E   L +      G+  D S  +  A +NV+  +
Sbjct: 123 LHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLI 182

Query: 186 LFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLA 245
            F   +   D E   +     G +  +S       ++  W L+  P    + L     + 
Sbjct: 183 CFNTSYKNGDPELNVIQNYNEGIIDNLSKDS--LVDLVPW-LKIFPNKTLEKLKSHVKIR 239

Query: 246 AFTVRQVQQHQGNLDASGPARDLVDAFL-LKMAQEEQNPG----TEFTNKNMLMTVIYLL 300
              + ++ ++      S    +++D  +  KM  +  N G    +E  + N ++T I  +
Sbjct: 240 NDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDI 299

Query: 301 F-AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHE 359
           F AG  T ++ V +TL  L+  P V+K + EE+++ +G  + P++ DR RL   +A + E
Sbjct: 300 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIRE 359

Query: 360 AQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419
             RL  + PM IP      +    + + +GTEV   L ++ H+   +  P++F P+RFL+
Sbjct: 360 VLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419

Query: 420 ADGR--FRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPT 477
             G        ++LPF  G R C+GE LA+ ELFL    +LQ F LE P      SL+  
Sbjct: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGI 479

Query: 478 VSGLFNIPPAFQLQVR 493
              +F I  +F+++++
Sbjct: 480 PKVVFLI-DSFKVKIK 494


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  161 bits (408), Expect = 1e-39
 Identities = 148/512 (28%), Positives = 238/512 (46%), Gaps = 64/512 (12%)

Query: 10  LLALALLLLLTLALSGTRARG--------HLPPGPTPLPLLGNLLQLRPGALYSGLMRLS 61
           +L L LLLLL L L+G R           HLPP      L    L L    L   L+ L+
Sbjct: 1   MLLLGLLLLLPL-LAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLT 53

Query: 62  KKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNG 121
           +K+GP++ ++LG             +++ L  +       G  ++L              
Sbjct: 54  QKFGPIYRLHLG-------------LQDKLVSRNYPDLSLGDYSLL-------------- 86

Query: 122 ERWRQLRKFTMLALRDLGMGKREG-EELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180
             W+  +K T  AL    +G R+  E +++   +   E  +   G P       +  T +
Sbjct: 87  --WKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCS 141

Query: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPH-KQLLH 239
           ++C L FG +   +D    A  +     L   S    Q  ++   FLR  P P  ++L  
Sbjct: 142 IICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 199

Query: 240 HVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGT-EFTNKNMLMTVIY 298
            +         Q++QH+ +L A G  RD++D  L  +AQ     G+ +    ++ M  + 
Sbjct: 200 AIEKRDHIVEMQLRQHKESLVA-GQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVD 258

Query: 299 LLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS---LGDRTRLPYTDA 355
           LL  GT T + T+ + ++ L+ +P +Q+ ++EEL+ ELG G + S     DR RLP  +A
Sbjct: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318

Query: 356 VLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPD 415
            + E  RL  +VP+ +P    R +   GY +P+GT + P L     D  +++ P EF PD
Sbjct: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378

Query: 416 RFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS-LESPCPPDTLSL 474
           RFL+      K+   L F  G RVCLGE LA+ ELF+  T +LQAF+ L S     +L  
Sbjct: 379 RFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQP 434

Query: 475 KPTVSGLFNIPPAFQLQVRPTDL--HSTTQTR 504
            P  S +  + P FQ++++P  +  HS  Q++
Sbjct: 435 LPHCSVILKMQP-FQVRLQPRGMGAHSPGQSQ 465


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  122 bits (306), Expect = 8e-28
 Identities = 135/513 (26%), Positives = 223/513 (43%), Gaps = 43/513 (8%)

Query: 3   ATGTWALLLALALLLLLTLALSGTRARGHLP----PGPTPLPLLGNLLQLRPGALYSGLM 58
           A  TW LLLA++L+LL    L GTR  G       PGPTPLPLLGN+L  R G L+    
Sbjct: 8   AVETW-LLLAVSLVLLY---LYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQG-LWKFDT 62

Query: 59  RLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEE-FSGRGTVAMLEGTFDGHGVF 117
              KKYG ++  Y G   PV+ +   + +R  L  +    F+ R ++  +   F    + 
Sbjct: 63  ECYKKYGKMWGTYEGQL-PVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG--FMKSAIS 119

Query: 118 FSNGERWRQLRK-----FTMLALRDL-GMGKREGEELIQAEARCLVETFQGTEGRPFDPS 171
            +  E W+++R      FT   L+++  +  + G+ L++   R      +  +G+P    
Sbjct: 120 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRR------EAEKGKPVTLK 173

Query: 172 LLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMF-SWFLRPL 230
            +    + +V+    FG+     +      V +    L     + G    +F S  L P 
Sbjct: 174 DIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL-----KFGFLDPLFLSIILFPF 228

Query: 231 PGPHKQLLHHVSTLAAFTVRQVQQHQGNLDAS---GPARDLVDAFLLKMAQEEQNPGTE- 286
             P  + L+ VS     T+  + +    +  S      +  +D FL  M   + +  TE 
Sbjct: 229 LTPVFEALN-VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETES 286

Query: 287 ---FTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS 343
               ++  +    I  +FAG  T S+ + +TL  L  +P VQ+ +++E++  L     P+
Sbjct: 287 HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT 346

Query: 344 LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDP 403
                ++ Y D V++E  RL   V + + RT  +     G  +P+G+ V     ++ HDP
Sbjct: 347 YDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 405

Query: 404 NIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL 463
             +  PEEF P+RF         +  + PF  G R C+G   A   + L    +LQ FS 
Sbjct: 406 KYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464

Query: 464 ESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTD 496
           + PC    + LK    GL        L+V   D
Sbjct: 465 K-PCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  120 bits (300), Expect = 4e-27
 Identities = 124/493 (25%), Positives = 212/493 (43%), Gaps = 36/493 (7%)

Query: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPL-----PLLGNLLQLRPGA--LYSGLMRL 60
           AL LA A L+L  L    + AR      P P      PL+G+ L ++P     +  ++  
Sbjct: 21  ALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEY 80

Query: 61  SKKYG--PVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFF 118
           +++Y   P+  +++GP  P+V L   E V E +   +++         LE    G G+  
Sbjct: 81  TEEYRHMPLLKLWVGPV-PMVALYNAENV-EVILTSSKQIDKSSMYKFLEPWL-GLGLLT 137

Query: 119 SNGERWRQLRK-----FTMLALRDLGMGKREGEELIQAEARCLVETFQG-TEGRPFDPSL 172
           S G +WR  RK     F    L D         +++  +A  LV+  +       F+   
Sbjct: 138 STGNKWRSRRKMLTPTFHFTILEDF-------LDIMNEQANILVKKLEKHINQEAFNCFF 190

Query: 173 LLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFS-WFLRPLP 231
            +     +++C    G     +  +    VRA       +  +    +     W+L    
Sbjct: 191 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKE 250

Query: 232 G-PHKQLLH--HVSTLAAFTVRQVQQH-----QGNLDASGPARDLVDAFLLKMAQEEQNP 283
           G  HK+ L   H  T +    R  + +     +G+   S P+++   AFL  +     + 
Sbjct: 251 GWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDE 310

Query: 284 GTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS 343
           G   +++++   V   +F G  T +  + ++L LL   P VQK V  EL+   G    P+
Sbjct: 311 GNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPA 370

Query: 344 -LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHD 402
            + D  +L Y + V+ E  RL   VP+   R++       GY + +GTE   +  ++  D
Sbjct: 371 TVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRD 429

Query: 403 PNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS 462
           P  F +PEEF P+RF   + + R   A++PFS G R C+G+  A  E     + IL+ F 
Sbjct: 430 PRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFW 489

Query: 463 LESPCPPDTLSLK 475
           +ES    + L L+
Sbjct: 490 IESNQKREELGLE 502


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  112 bits (280), Expect = 8e-25
 Identities = 129/498 (25%), Positives = 211/498 (42%), Gaps = 42/498 (8%)

Query: 3   ATGTWALLLALALLLLLTLALSGTRARGHLP----PGPTPLPLLGNLLQLRPGALYSGLM 58
           A  TW LLLA++L+LL    L GTR  G       PGPTPLP LGN L  R G  ++  M
Sbjct: 8   AVETW-LLLAVSLILLY---LYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKG-YWTFDM 62

Query: 59  RLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEE-FSGR---GTVAMLEGTFDGH 114
              KKY  V+ IY    +P++ +   + ++  L  +    F+ R   G V  ++     +
Sbjct: 63  ECYKKYRKVWGIY-DCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK-----N 116

Query: 115 GVFFSNGERWRQLRK-----FTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFD 169
            +  +  E W+++R      FT   L+++     +  +++    R   ET     G+P  
Sbjct: 117 AISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-----GKPVT 171

Query: 170 PSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTL-LGVSSQGGQTYEMFSWFLR 228
              +    + +V+ S  FG+     +      V      L          + ++F  FL 
Sbjct: 172 LKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFP-FLT 230

Query: 229 PLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFT 288
           P+       +     ++  T    Q  +G L  +   R  VD   L++  + QN     T
Sbjct: 231 PILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHR--VD--FLQLMIDSQNSKDSET 286

Query: 289 NK-----NMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS 343
           +K      ++   I  +FAG  T S+ + + +  L  +P VQ+ V++E++  L     P+
Sbjct: 287 HKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPT 346

Query: 344 LGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDP 403
                +L Y D V++E  RL   V M + R   +     G  +P+G  V      + HDP
Sbjct: 347 YDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDP 405

Query: 404 NIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL 463
             +  PE+F P+RF   +        + PF  G R C+G   A   + L    +LQ FS 
Sbjct: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465

Query: 464 ESPCPPDTLSLKPTVSGL 481
           + PC    + LK    GL
Sbjct: 466 K-PCKETQIPLKLRFGGL 482


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  109 bits (272), Expect = 7e-24
 Identities = 127/518 (24%), Positives = 212/518 (40%), Gaps = 52/518 (10%)

Query: 3   ATGTWALLLALALLLLLTLALSGTRARGHLP----PGPTPLPLLGNLLQLRPGALYSGLM 58
           A  TW LLLA++L+LL    L GT + G       PGPTPLP LGN+L    G      M
Sbjct: 8   AMETW-LLLAVSLVLLY---LYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFD-M 62

Query: 59  RLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEE-FSGR---GTVAMLEGTFDGH 114
              KKYG V+  Y G  +PV+ +   + ++  L  +    F+ R   G V  ++      
Sbjct: 63  ECHKKYGKVWGFYDGQ-QPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA---- 117

Query: 115 GVFFSNGERWRQLRK-----FTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFD 169
            +  +  E W++LR      FT   L+++     +  +++    R   ET     G+P  
Sbjct: 118 -ISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET-----GKPVT 171

Query: 170 PSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFS-WFLR 228
              +    + +V+ S  FG+     +      V      L          ++    +FL 
Sbjct: 172 LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL---------RFDFLDPFFLS 222

Query: 229 PLPGPHKQLLHHVSTLAAFT------VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQN 282
               P    +  V  +  F       +R+  +           +  VD FL  M   + +
Sbjct: 223 ITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDSQNS 281

Query: 283 PGTE----FTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGA 338
             TE     ++  ++   I  +FAG  T S+ + + +  L  +P VQ+ ++EE++  L  
Sbjct: 282 KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN 341

Query: 339 GQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGS 398
              P+     ++ Y D V++E  RL   + M + R   +     G  +P+G  V     +
Sbjct: 342 KAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400

Query: 399 ILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTIL 458
           +  DP  +  PE+F P+RF   +        + PF  G R C+G   A   + L    +L
Sbjct: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460

Query: 459 QAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTD 496
           Q FS + PC    + LK ++ GL        L+V   D
Sbjct: 461 QNFSFK-PCKETQIPLKLSLGGLLQPEKPVVLKVESRD 497


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  103 bits (257), Expect = 4e-22
 Identities = 118/458 (25%), Positives = 193/458 (42%), Gaps = 55/458 (12%)

Query: 34  PGPTPLPLLGNLLQ-LRPGAL---YSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVRE 89
           PGPT  PLLG+LLQ L  G L   +  L+   KKYG +F + LG +  V +  G   + E
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL--GSPCLLE 116

Query: 90  ALGGQAEEFSGRGTV----AMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREG 145
           AL      +  R  +    A  +   +G+G+    GE W+++R      L   G   +  
Sbjct: 117 ALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLD 176

Query: 146 EEL--IQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVR 203
            ++  + A+    ++      G   D    L + +   +C +L+  RF    K       
Sbjct: 177 NKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN---AGD 233

Query: 204 AAGGTLLGVSSQGGQTYEMFSWFLRPLPGP---HKQLLHHV---STLAAFTVRQVQQHQG 257
            A   ++ + +       M S F R +  P   HK L   V    TLA  T+ +      
Sbjct: 234 EAVNFIMAIKT-------MMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFK------ 280

Query: 258 NLDASGPARDLVDAFLLKMAQEEQNPGTEF----------TNKNMLMTVIYLLFAGTMTV 307
                   +  +D  L K +Q+   P  +F          + K +   V  L  A   T 
Sbjct: 281 ------SVKACIDNRLEKYSQQ---PSADFLCDIYHQNRLSKKELYAAVTELQLAAVETT 331

Query: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367
           + ++ + L  L + P VQ+ + +E+   L   Q P   D   +PY  A L E+ RL   V
Sbjct: 332 ANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSV 391

Query: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427
           P    RTL + T    Y LP+GT +      +    + F+   +F P+R+L    +    
Sbjct: 392 PF-TTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPF 450

Query: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLES 465
            A LPF +GKR+C+G  LA+ +L L    I++ + +++
Sbjct: 451 -AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQA 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,433,248
Number of Sequences: 37866
Number of extensions: 966807
Number of successful extensions: 2565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2338
Number of HSP's gapped (non-prelim): 111
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.