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Search of human proteins with 61175232
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
(316 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61175232 hypothetical protein LOC221424 [Homo sapiens] 619 e-177
gi|118918429 NOD3 protein [Homo sapiens] 69 4e-12
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 69 7e-12
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ... 67 3e-11
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ... 67 3e-11
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ... 67 3e-11
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 61 1e-09
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 61 1e-09
gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens] 60 3e-09
gi|23503285 leucine rich repeat containing 34 [Homo sapiens] 58 1e-08
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 57 2e-08
gi|5174617 nucleotide-binding oligomerization domain containing ... 52 9e-07
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 50 3e-06
gi|149274621 centrosomal protein 78kDa isoform a [Homo sapiens] 50 3e-06
gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens] 50 3e-06
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 49 4e-06
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 49 4e-06
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 49 6e-06
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 49 8e-06
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 49 8e-06
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 49 8e-06
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 48 1e-05
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 47 2e-05
>gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
Length = 316
Score = 619 bits (1595), Expect = e-177
Identities = 316/316 (100%), Positives = 316/316 (100%)
Query: 1 MLPSSIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQ 60
MLPSSIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQ
Sbjct: 1 MLPSSIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQ 60
Query: 61 LNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDL 120
LNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDL
Sbjct: 61 LNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDL 120
Query: 121 GDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNL 180
GDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNL
Sbjct: 121 GDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNL 180
Query: 181 DYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAEN 240
DYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAEN
Sbjct: 181 DYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAEN 240
Query: 241 SISPELQQQICDLLSEGEEEEEVAGGAGDTQEWERGREPAAHQRGSSSWMCPSDPSSQMV 300
SISPELQQQICDLLSEGEEEEEVAGGAGDTQEWERGREPAAHQRGSSSWMCPSDPSSQMV
Sbjct: 241 SISPELQQQICDLLSEGEEEEEVAGGAGDTQEWERGREPAAHQRGSSSWMCPSDPSSQMV 300
Query: 301 LMTSGLGDSLLAETEM 316
LMTSGLGDSLLAETEM
Sbjct: 301 LMTSGLGDSLLAETEM 316
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 69.3 bits (168), Expect = 4e-12
Identities = 69/249 (27%), Positives = 107/249 (42%), Gaps = 44/249 (17%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNL 65
+++ G LSG + R ++ +SL ++ ++ + R+L SL L+L
Sbjct: 654 MELLGSVLSGKDCR----------IQKISLAENQISNKGAKALARSLLVNRSLTSLDLR- 702
Query: 66 GVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCML 125
G P K LA+AL+ NR++ SL L G+ + D G + ALA + L L L +
Sbjct: 703 GNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSI 762
Query: 126 GDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPL 185
G P G R+A A+ + ++ L N +
Sbjct: 763 G--------------------------------PMGAQRMADALKQNRSLKELMFSSNSI 790
Query: 186 GDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPE 245
GD A LA A+ ++ LE LDL+ +++ L+ + T L SL L ENSISPE
Sbjct: 791 GDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLL-SLSLRENSISPE 849
Query: 246 LQQQICDLL 254
Q I L
Sbjct: 850 GAQAIAHAL 858
Score = 69.3 bits (168), Expect = 4e-12
Identities = 69/253 (27%), Positives = 118/253 (46%), Gaps = 7/253 (2%)
Query: 4 SSIQISGEPLSGAEVRDICRGLRDN-AVRLLSLRGCRLCDRDFGRICRALAGATSLAQLN 62
+S+ + G + R + L N + +L L+ + R+ AL SL +L
Sbjct: 725 TSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELM 784
Query: 63 LNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ + K LAEAL+ N+ ++SL L + ++DAG+A L AL + L++L L +
Sbjct: 785 FSSNSIGDGGA-KALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRE 843
Query: 123 CMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+ E I L A S LK L L+AN + +G +A+AV + + L+L +
Sbjct: 844 NSISPEGAQAIAHAL---CANSTLKNLDLTANL-LHDQGARAIAVAVRENRTLTSLHLQW 899
Query: 183 NPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSI 242
N + A L A+ +R+L LDL+ + + A + ++ TAL +L L SI
Sbjct: 900 NFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALK-VNTALTALYLQVASI 958
Query: 243 SPELQQQICDLLS 255
Q + + L+
Sbjct: 959 GASGAQVLGEALA 971
Score = 57.8 bits (138), Expect = 1e-08
Identities = 64/253 (25%), Positives = 109/253 (43%), Gaps = 29/253 (11%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRL-LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
S+ + +S A V + L N L LSLR + I AL ++L L+L
Sbjct: 810 SLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDL 869
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
++ + +A A+R NR++ SL L + + L AL L+ +L +LDL +
Sbjct: 870 TANLLHDQGA-RAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQEN 928
Query: 124 MLGDEAINLICGLLPPDGAKSGL-------------------------KELTLSANPGIT 158
+GD+ + L + A + L + L L N I
Sbjct: 929 AIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGN-AIG 987
Query: 159 PKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSA 218
G LA A+ +S +R LNL N LG A +A A++ + L+ ++L+G + + A
Sbjct: 988 VAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGA 1047
Query: 219 QTLLDMVE-NYPT 230
+ + + ++ N PT
Sbjct: 1048 RMISEAIKTNAPT 1060
Score = 45.4 bits (106), Expect = 6e-05
Identities = 38/137 (27%), Positives = 71/137 (51%), Gaps = 4/137 (2%)
Query: 127 DEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLG 186
D + L+ +L G +++++L+ N I+ KG LA ++ + + L+L N +G
Sbjct: 651 DPVMELLGSVL--SGKDCRIQKISLAENQ-ISNKGAKALARSLLVNRSLTSLDLRGNSIG 707
Query: 187 DHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPEL 246
A LA A+ +RTL L L+G + + A+++ + + + T L L L +NSI P
Sbjct: 708 PQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRT-LSMLHLQKNSIGPMG 766
Query: 247 QQQICDLLSEGEEEEEV 263
Q++ D L + +E+
Sbjct: 767 AQRMADALKQNRSLKEL 783
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 68.6 bits (166), Expect = 7e-12
Identities = 75/253 (29%), Positives = 114/253 (45%), Gaps = 9/253 (3%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLR--GCRLCDRDFGRICRALAGATSLAQLNL 63
+ + G + V+ +C L+ +L +LR C L I AL + SL LNL
Sbjct: 734 LDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNL 793
Query: 64 NLGVVSSPSRIKQLAEALRTNRS-IQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ + ++ L EALR + ++ L L LT+AG L+ AL + L L L D
Sbjct: 794 STNNLLDDG-VQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLAD 852
Query: 123 CMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+ L A+ LK L L T L+ ++ H+ + L+L
Sbjct: 853 NVLGDGGVKLMSDAL--QHAQCTLKSLVL-RRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
Query: 183 NPLGDHVAGMLA-VAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N L D+ +L V S L+ L+L G LTN L ++ N P LRSL L N
Sbjct: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPN-LRSLDLGNND 968
Query: 242 ISPELQQQICDLL 254
+ + + +CD L
Sbjct: 969 LQDDGVKILCDAL 981
Score = 39.7 bits (91), Expect = 0.004
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 7/198 (3%)
Query: 30 VRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALR-TNRSIQ 88
++ L LR C + +L SL L+L + + +K L + R + ++Q
Sbjct: 874 LKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD-NGVKLLCDVFRHPSCNLQ 932
Query: 89 SLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKE 148
L L G LT+A L + +P L +LDLG+ L D+ + ++C L ++
Sbjct: 933 DLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNC--NIQR 990
Query: 149 LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLG-DHVAGMLAVAVASSRTLEVLD 207
L L G+T L+ A+ + ++ +NL N LG + + + V + L+VL
Sbjct: 991 LGLE-YCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLG 1049
Query: 208 LEGTGLTNQSAQTLLDMV 225
L ++ AQ LL+ V
Sbjct: 1050 LCKEAF-DEEAQKLLEAV 1066
>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 66.6 bits (161), Expect = 3e-11
Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 6/218 (2%)
Query: 26 RDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNR 85
+ + ++ L R L D + RAL +SLA L+L +S + LA AL+ N
Sbjct: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRP-LMLLATALKMNM 260
Query: 86 SIQSLFLHGSPLTDA-GLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKS 144
+++ L+L + L A L L + +L LDL + + D + IC L +
Sbjct: 261 NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQ--RK 318
Query: 145 GLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 204
GL L L N +T G + L + + H+ + LNL +NP+G+ L + S+R++
Sbjct: 319 GLVTLVLWNNQ-LTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL 377
Query: 205 VLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSI 242
L L T LT + A + + + P LR L L EN I
Sbjct: 378 RLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEI 414
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 149 LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDL 208
L +S N I +GW A + +S ++ L+ PL DH A +A A+ +L VL L
Sbjct: 180 LNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHL 239
Query: 209 EGTGLTNQSAQTLLDMVENYPTALRSLVLAENSIS 243
E L+ + LL LR L LA+N ++
Sbjct: 240 ENASLSGRPLM-LLATALKMNMNLRELYLADNKLN 273
Score = 31.6 bits (70), Expect = 0.96
Identities = 42/190 (22%), Positives = 73/190 (38%), Gaps = 5/190 (2%)
Query: 57 SLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALV 116
S LN++ + A +R +Q L +PL D + AL + +L
Sbjct: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
Query: 117 ALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVR 176
L L + L + L+ L L+EL L+ N + ++L + + ++
Sbjct: 236 VLHLENASLSGRPLMLLATALK---MNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
Query: 177 VLNLDYNPLGDHVAGMLAVAVASSRT-LEVLDLEGTGLTNQSAQTLLDMVENYPTALRSL 235
+L+L N + D + + R L L L LT+ + L M + +L +L
Sbjct: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTH-TGMAFLGMTLPHTQSLETL 351
Query: 236 VLAENSISPE 245
L N I E
Sbjct: 352 NLGHNPIGNE 361
>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 66.6 bits (161), Expect = 3e-11
Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 6/218 (2%)
Query: 26 RDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNR 85
+ + ++ L R L D + RAL +SLA L+L +S + LA AL+ N
Sbjct: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRP-LMLLATALKMNM 260
Query: 86 SIQSLFLHGSPLTDA-GLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKS 144
+++ L+L + L A L L + +L LDL + + D + IC L +
Sbjct: 261 NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQ--RK 318
Query: 145 GLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 204
GL L L N +T G + L + + H+ + LNL +NP+G+ L + S+R++
Sbjct: 319 GLVTLVLWNNQ-LTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL 377
Query: 205 VLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSI 242
L L T LT + A + + + P LR L L EN I
Sbjct: 378 RLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEI 414
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 149 LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDL 208
L +S N I +GW A + +S ++ L+ PL DH A +A A+ +L VL L
Sbjct: 180 LNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHL 239
Query: 209 EGTGLTNQSAQTLLDMVENYPTALRSLVLAENSIS 243
E L+ + LL LR L LA+N ++
Sbjct: 240 ENASLSGRPLM-LLATALKMNMNLRELYLADNKLN 273
Score = 31.6 bits (70), Expect = 0.96
Identities = 42/190 (22%), Positives = 73/190 (38%), Gaps = 5/190 (2%)
Query: 57 SLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALV 116
S LN++ + A +R +Q L +PL D + AL + +L
Sbjct: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
Query: 117 ALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVR 176
L L + L + L+ L L+EL L+ N + ++L + + ++
Sbjct: 236 VLHLENASLSGRPLMLLATALK---MNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
Query: 177 VLNLDYNPLGDHVAGMLAVAVASSRT-LEVLDLEGTGLTNQSAQTLLDMVENYPTALRSL 235
+L+L N + D + + R L L L LT+ + L M + +L +L
Sbjct: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTH-TGMAFLGMTLPHTQSLETL 351
Query: 236 VLAENSISPE 245
L N I E
Sbjct: 352 NLGHNPIGNE 361
>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 66.6 bits (161), Expect = 3e-11
Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 6/218 (2%)
Query: 26 RDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNR 85
+ + ++ L R L D + RAL +SLA L+L +S + LA AL+ N
Sbjct: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRP-LMLLATALKMNM 260
Query: 86 SIQSLFLHGSPLTDA-GLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKS 144
+++ L+L + L A L L + +L LDL + + D + IC L +
Sbjct: 261 NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQ--RK 318
Query: 145 GLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 204
GL L L N +T G + L + + H+ + LNL +NP+G+ L + S+R++
Sbjct: 319 GLVTLVLWNNQ-LTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL 377
Query: 205 VLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSI 242
L L T LT + A + + + P LR L L EN I
Sbjct: 378 RLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEI 414
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 149 LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDL 208
L +S N I +GW A + +S ++ L+ PL DH A +A A+ +L VL L
Sbjct: 180 LNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHL 239
Query: 209 EGTGLTNQSAQTLLDMVENYPTALRSLVLAENSIS 243
E L+ + LL LR L LA+N ++
Sbjct: 240 ENASLSGRPLM-LLATALKMNMNLRELYLADNKLN 273
Score = 31.6 bits (70), Expect = 0.96
Identities = 42/190 (22%), Positives = 73/190 (38%), Gaps = 5/190 (2%)
Query: 57 SLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALV 116
S LN++ + A +R +Q L +PL D + AL + +L
Sbjct: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
Query: 117 ALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVR 176
L L + L + L+ L L+EL L+ N + ++L + + ++
Sbjct: 236 VLHLENASLSGRPLMLLATALK---MNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
Query: 177 VLNLDYNPLGDHVAGMLAVAVASSRT-LEVLDLEGTGLTNQSAQTLLDMVENYPTALRSL 235
+L+L N + D + + R L L L LT+ + L M + +L +L
Sbjct: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTH-TGMAFLGMTLPHTQSLETL 351
Query: 236 VLAENSISPE 245
L N I E
Sbjct: 352 NLGHNPIGNE 361
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 61.2 bits (147), Expect = 1e-09
Identities = 68/250 (27%), Positives = 111/250 (44%), Gaps = 11/250 (4%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLN 64
S+ I E LS A ++ L+ +++ L C L + I AL +LA+LNL
Sbjct: 7 SLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAELNLR 64
Query: 65 LGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + + + L+T + IQ L L LT AG +L+ L P L L L D
Sbjct: 65 SNELGDVG-VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
Query: 124 MLGDEAINLIC-GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDY 182
+LGD + L+C GLL P + L++L L ++ LA + + L +
Sbjct: 124 LLGDAGLQLLCEGLLDP---QCRLEKLQLE-YCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 183 NPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENS 241
N + + +L + S LE L LE G+T+ + + L +V + +LR L L N
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS-KASLRELALGSNK 238
Query: 242 ISPELQQQIC 251
+ ++C
Sbjct: 239 LGDVGMAELC 248
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/274 (22%), Positives = 105/274 (38%), Gaps = 30/274 (10%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +S ++ A VR +C+GL+D+ +L L L C + + +C +A SL +L L
Sbjct: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 64 NLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDC 123
+ + L + +++L++ +T G L L +L L L
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 124 MLGDEAINLICGLLPPDGAKSG--------------------------LKELTLSANPGI 157
LGDE L+C L G + L EL +S N +
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNR-L 353
Query: 158 TPKGWSRLAIAVAHSSQV-RVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQ 216
G L + V RVL L + D LA + ++ +L LDL L +
Sbjct: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
Query: 217 SAQTLLDMVENYPTALRSLVLAENSISPELQQQI 250
L++ V L LVL + S E++ ++
Sbjct: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRL 447
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 60.8 bits (146), Expect = 1e-09
Identities = 71/256 (27%), Positives = 119/256 (46%), Gaps = 9/256 (3%)
Query: 5 SIQISGEPLSGAEVRDICRGLRDNAVRLLSLR--GCRLCDRDFGRICRALAGATSLAQLN 62
S+ + G L +VR C L+ L SLR C L + +I + L + SL L+
Sbjct: 841 SLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS 900
Query: 63 LNLGVVSSPSRIKQLAEALRTNR-SIQSLFLHGSPLTDAGLALLNPALALHPALVALDLG 121
L V+ + L++ALR ++ ++Q L L +T G L AL + +L L L
Sbjct: 901 LAGNKVTDQG-VMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLS 959
Query: 122 DCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLD 181
+ LG+E +NL+C + L+ L L+ + G LA+A+ +S + L+L
Sbjct: 960 NNSLGNEGVNLLCRSMRL--PHCSLQRLMLN-QCHLDTAGCGFLALALMGNSWLTHLSLS 1016
Query: 182 YNPLGDHVAGMLA-VAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAEN 240
NP+ D+ +L V S L+ L+L LT ++ L V + L+SL L +N
Sbjct: 1017 MNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCES-LSCVISRSRHLKSLDLTDN 1075
Query: 241 SISPELQQQICDLLSE 256
++ +C+ L +
Sbjct: 1076 ALGDGGVAALCEGLKQ 1091
Score = 42.0 bits (97), Expect = 7e-04
Identities = 43/147 (29%), Positives = 65/147 (44%), Gaps = 6/147 (4%)
Query: 109 LALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIA 168
L HP L LDLG +L + A+ +C L K + + N ITP G L
Sbjct: 777 LGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI---QTLMFRNAQITP-GVQHLWRI 832
Query: 169 VAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSR-TLEVLDLEGTGLTNQSAQTLLDMVEN 227
V + +R LNL L + M A+ + LE L L+ GLT+ + ++
Sbjct: 833 VMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTT 892
Query: 228 YPTALRSLVLAENSISPELQQQICDLL 254
P +L+SL LA N ++ + + D L
Sbjct: 893 SP-SLKSLSLAGNKVTDQGVMPLSDAL 918
>gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]
Length = 501
Score = 59.7 bits (143), Expect = 3e-09
Identities = 55/182 (30%), Positives = 89/182 (48%), Gaps = 6/182 (3%)
Query: 77 LAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGL 136
LA A++ +++ L S + D ++ +L HP L LDL ++GD L
Sbjct: 271 LAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKL 330
Query: 137 LPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVA 196
L + S L+ L L AN + G LA A+AH++ + LNL N + D LA A
Sbjct: 331 L----SHSRLRVLNL-ANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHA 385
Query: 197 VASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLSE 256
+ +++ L L L G L+ +A TLL V T L S+ L+ N I + +Q+ + +S+
Sbjct: 386 LQTNKCLTTLHLGGNELSEPTA-TLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSD 444
Query: 257 GE 258
+
Sbjct: 445 NK 446
Score = 46.2 bits (108), Expect = 4e-05
Identities = 38/145 (26%), Positives = 67/145 (46%), Gaps = 13/145 (8%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNL 65
+ +S + R + L + +R+L+L ++ + ALA T+L LNL L
Sbjct: 312 LDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRL 371
Query: 66 GVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCML 125
+ + LA AL+TN+ + +L L G+ L++ LL+ LA++ L
Sbjct: 372 NCIEDEGG-QALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLT--------- 421
Query: 126 GDEAINLICGLLPPDGAKSGLKELT 150
+INL C + DG K L+ ++
Sbjct: 422 ---SINLSCNHIGLDGGKQLLEGMS 443
>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
Length = 419
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/206 (25%), Positives = 94/206 (45%), Gaps = 6/206 (2%)
Query: 40 LCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTD 99
LCD + L +L LNL + P + +A+ L NR+++ L + G+ + +
Sbjct: 122 LCDVGAYYAAKLLQKQLNLIYLNLMFNDIG-PEGGELIAKVLHKNRTLKYLRMTGNKIEN 180
Query: 100 AGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITP 159
G L ++ +L LDLGDC L + ++ + +L + L I
Sbjct: 181 KGGMFFAAMLQINSSLEKLDLGDCDLEESTVH-VGRMLKENHCLVALH----MCKHDIKN 235
Query: 160 KGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQ 219
G +L A+ +S +R L++ N + LA + S+ TLEV+DL + N A
Sbjct: 236 SGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGAN 295
Query: 220 TLLDMVENYPTALRSLVLAENSISPE 245
L + + ++ +L++L + N+I E
Sbjct: 296 YLSETLTSHNRSLKALSVVSNNIEGE 321
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 57.0 bits (136), Expect = 2e-08
Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 8/196 (4%)
Query: 48 ICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNP 107
+ RAL G L +L+L+ +++S S + L L +QSL L+ + + D G L+
Sbjct: 1542 LMRALEGKWMLKRLDLSHLLLNS-STLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSE 1600
Query: 108 ALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAI 167
AL +L LDL +GD + + +LP L+++ LS N I+ G +LA
Sbjct: 1601 ALRAATSLEELDLSHNQIGDAGVQHLATILP---GLPELRKIDLSGN-SISSAGGVQLAE 1656
Query: 168 AVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVEN 227
++ ++ L L N LGD A L +A + L VL L + L A +L ++
Sbjct: 1657 SLVLCRRLEELMLGCNALGDPTA--LGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDG 1714
Query: 228 YPTALRSLVLAENSIS 243
P L + LAEN+++
Sbjct: 1715 SP-HLEEISLAENNLA 1729
Score = 40.8 bits (94), Expect = 0.002
Identities = 52/190 (27%), Positives = 75/190 (39%), Gaps = 7/190 (3%)
Query: 75 KQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLIC 134
K L AL ++ L L L + LALL L+ L +L L +GD C
Sbjct: 1540 KALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVG---CC 1596
Query: 135 GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLA 194
L A + L+EL LS N I G LA + ++R ++L N + LA
Sbjct: 1597 HLSEALRAATSLEELDLSHNQ-IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLA 1655
Query: 195 VAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLL 254
++ R LE L L G T L + + P LR L L + + P + L
Sbjct: 1656 ESLVLCRRLEELML---GCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQAL 1712
Query: 255 SEGEEEEEVA 264
EE++
Sbjct: 1713 DGSPHLEEIS 1722
Score = 34.7 bits (78), Expect = 0.11
Identities = 64/267 (23%), Positives = 103/267 (38%), Gaps = 50/267 (18%)
Query: 32 LLSLRGCRLCDRDFG--RICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQS 89
L SLR R D G + AL ATSL +L+L+ + ++ LA L ++
Sbjct: 1580 LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAG-VQHLATILPGLPELRK 1638
Query: 90 LFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGD--------------EAINLICG 135
+ L G+ ++ AG L +L L L L LG LGD ++L
Sbjct: 1639 IDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLRVLHLPFS 1698
Query: 136 LLPPDGAKS---------GLKELTLSANP-----------------------GITPKGWS 163
L P GA S L+E++L+ N I +
Sbjct: 1699 HLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAK 1758
Query: 164 RLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSAQTLLD 223
L + + V+ L +N LGD A LA + L+ +DLE +T A L +
Sbjct: 1759 LLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAE 1818
Query: 224 MVENYPTALRSLVLAENSISPELQQQI 250
+ ++++ + L N I ++ Q +
Sbjct: 1819 GLAQ-GSSIQVIRLWNNPIPCDMAQHL 1844
Score = 31.2 bits (69), Expect = 1.3
Identities = 62/227 (27%), Positives = 92/227 (40%), Gaps = 24/227 (10%)
Query: 31 RLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNL-GVVSSPSRIKQLAEALRTNRSIQS 89
R + L C L ++ ++C+AL G+ L L+L+ G +LA+ L ++QS
Sbjct: 977 RRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQS 1036
Query: 90 LFLHGSPLT-DAGLALLNPALALHPALVALDLG-----DCMLGDEAIN--LICGLLP--P 139
L L + L+ DA L L+ L L LD+ + GD+ G LP P
Sbjct: 1037 LNLSENGLSLDAVLGLVRCFSTLQ-WLFRLDISFESQHILLRGDKTSRDMWATGSLPDFP 1095
Query: 140 DGAK-SGLKE------LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGM 192
AK G ++ L LS P + P +RL + L L L D
Sbjct: 1096 AAAKFLGFRQRCIPRSLCLSECP-LEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
Query: 193 LAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTA----LRSL 235
L + L +L L TGL+ +S L + + P LRSL
Sbjct: 1155 LLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSL 1201
Score = 28.5 bits (62), Expect = 8.2
Identities = 37/158 (23%), Positives = 53/158 (33%), Gaps = 20/158 (12%)
Query: 93 HGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLI--CGLLPPDGAKS------ 144
H PLT LA L L A + LD C L + CG + KS
Sbjct: 642 HNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDA 701
Query: 145 ------------GLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGM 192
G ++ A IT +G S L A+ Q++ ++ N L D V
Sbjct: 702 FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLN 761
Query: 193 LAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPT 230
+ + L LDL + + L + PT
Sbjct: 762 IVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPT 799
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 51.6 bits (122), Expect = 9e-07
Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 34/216 (15%)
Query: 30 VRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQS 89
V L L ++ D + + L L L L ++S K LA A++ ++SI
Sbjct: 758 VTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGG-KYLALAVKNSKSISE 816
Query: 90 LFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKEL 149
+ + G+ + D G AL HP+L L L
Sbjct: 817 VGMWGNQVGDEGAKAFAEALRNHPSLTTLSL----------------------------- 847
Query: 150 TLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLE 209
A+ GI+ +G LA A+ ++ + +L L N L D VA LA + ++TL+ L L
Sbjct: 848 ---ASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLI 904
Query: 210 GTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPE 245
+T + L D +++ T + + L N I PE
Sbjct: 905 QNQITAKGTAQLADALQS-NTGITEICLNGNLIKPE 939
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 50.1 bits (118), Expect = 3e-06
Identities = 68/263 (25%), Positives = 104/263 (39%), Gaps = 51/263 (19%)
Query: 40 LCDRDFGRICRALAG--------ATSLAQLNLNLGVVS---SPSRIKQLAEALRTNRSIQ 88
L DR + R C++L A L L L+ S +++ L AL+ + +++
Sbjct: 1015 LTDR-YRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALR 1073
Query: 89 SLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKE 148
L L G+ L D +A L AL P+L LDL LG E + + LP L+E
Sbjct: 1074 ELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEE 1133
Query: 149 LTLSANP---------------------------GITPKGW----SRLAIAVAHSSQVRV 177
L LS NP G P + + L A + ++
Sbjct: 1134 LDLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKT 1193
Query: 178 LNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGL-TNQSAQTLLDMVENY----PTAL 232
L+L YN LG A LA + S +L LE + + + L++ V Y AL
Sbjct: 1194 LSLSYNALG---APALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCAL 1250
Query: 233 RSLVLAENSISPELQQQICDLLS 255
L L+ N + + + +C LS
Sbjct: 1251 AHLTLSANHLGDKAVRDLCRCLS 1273
>gi|149274621 centrosomal protein 78kDa isoform a [Homo sapiens]
Length = 722
Score = 49.7 bits (117), Expect = 3e-06
Identities = 52/212 (24%), Positives = 87/212 (41%), Gaps = 38/212 (17%)
Query: 44 DFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLA 103
D + CR+ A + L K L L + +++L L+G L + L
Sbjct: 87 DMNKFCRSRVPAIRYKDVTFQL--------CKALKGCLSISSVLKNLELNGLILRERDLT 138
Query: 104 LLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLS-ANPGITPKGW 162
+L L +LV L L +C +GD + +IC G KS + T++ +T +G
Sbjct: 139 ILAKGLNKSASLVHLSLANCPIGDGGLEIIC-----QGIKSSITLKTVNFTGCNLTWQGA 193
Query: 163 SRLAIAVAHSSQ-----------------------VRVLNLDYNPL-GDHVAGMLAVAVA 198
+A + + + +R + L+ N L GD A A +++
Sbjct: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
Query: 199 SSRTLEVLDLEGTGLTNQSAQTLLDMVENYPT 230
L LDL+ GLTN+ A+ LL+ +E T
Sbjct: 254 EDLWLRALDLQQCGLTNEGAKALLEALETNTT 285
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 23/194 (11%)
Query: 47 RICRALAGATSLAQLNLNL---GVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLA 103
++C+AL G S++ + NL G++ + LA+ L + S+ L L P+ D GL
Sbjct: 107 QLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLE 166
Query: 104 LLNPALALHPALVALDLGDCMLGDEAINLICGLL--------------------PPDGAK 143
++ + L ++ C L + + + +L P
Sbjct: 167 IICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCM 226
Query: 144 SGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 203
+GL+ +TL+ N I G A +++ +R L+L L + A L A+ ++ TL
Sbjct: 227 AGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTL 286
Query: 204 EVLDLEGTGLTNQS 217
VLD+ L + S
Sbjct: 287 VVLDIRKNPLIDHS 300
>gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens]
Length = 706
Score = 49.7 bits (117), Expect = 3e-06
Identities = 52/212 (24%), Positives = 87/212 (41%), Gaps = 38/212 (17%)
Query: 44 DFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLA 103
D + CR+ A + L K L L + +++L L+G L + L
Sbjct: 87 DMNKFCRSRVPAIRYKDVTFQL--------CKALKGCLSISSVLKNLELNGLILRERDLT 138
Query: 104 LLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLS-ANPGITPKGW 162
+L L +LV L L +C +GD + +IC G KS + T++ +T +G
Sbjct: 139 ILAKGLNKSASLVHLSLANCPIGDGGLEIIC-----QGIKSSITLKTVNFTGCNLTWQGA 193
Query: 163 SRLAIAVAHSSQ-----------------------VRVLNLDYNPL-GDHVAGMLAVAVA 198
+A + + + +R + L+ N L GD A A +++
Sbjct: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
Query: 199 SSRTLEVLDLEGTGLTNQSAQTLLDMVENYPT 230
L LDL+ GLTN+ A+ LL+ +E T
Sbjct: 254 EDLWLRALDLQQCGLTNEGAKALLEALETNTT 285
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 23/194 (11%)
Query: 47 RICRALAGATSLAQLNLNL---GVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLA 103
++C+AL G S++ + NL G++ + LA+ L + S+ L L P+ D GL
Sbjct: 107 QLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLE 166
Query: 104 LLNPALALHPALVALDLGDCMLGDEAINLICGLL--------------------PPDGAK 143
++ + L ++ C L + + + +L P
Sbjct: 167 IICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCM 226
Query: 144 SGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 203
+GL+ +TL+ N I G A +++ +R L+L L + A L A+ ++ TL
Sbjct: 227 AGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTL 286
Query: 204 EVLDLEGTGLTNQS 217
VLD+ L + S
Sbjct: 287 VVLDIRKNPLIDHS 300
>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
Length = 587
Score = 49.3 bits (116), Expect = 4e-06
Identities = 52/216 (24%), Positives = 96/216 (44%), Gaps = 12/216 (5%)
Query: 77 LAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGL 136
LAEA R +++ + + + + G+ L A A++P L ++L D ++ +
Sbjct: 200 LAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAET 259
Query: 137 LPPDGAKSGLKELTLSANPG---ITPKGWSRLAIAVAHS-SQVRVLNLDYNPLGDHVAGM 192
L L+++ + N G + KG +A A+ +++ LNL + + A
Sbjct: 260 LKT------LRQVEV-INFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALA 312
Query: 193 LAVAVASSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICD 252
+A A+A LE LDL G L + + L +++E + A + L + E +++ +
Sbjct: 313 VAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMA-KVLASLSDDEDEEEEEEGEE 371
Query: 253 LLSEGEEEEEVAGGAGDTQEWERGREPAAHQRGSSS 288
E EEEEE + +E E EP +G S
Sbjct: 372 EEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKS 407
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 49.3 bits (116), Expect = 4e-06
Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 14/199 (7%)
Query: 17 EVRDICRGLRDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQ 76
++ + RG D A + L++ CR + + L T +L L+ ++S
Sbjct: 26 QLHQLPRGRLDLATQSLTVETCRA-------LGKLLPRETLCTELVLSDCMLSEEGATL- 77
Query: 77 LAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLG--DEAINLIC 134
L L N ++ L L G+ L AG L L + ++ +L L LG D+A C
Sbjct: 78 LLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFC 137
Query: 135 GLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLA 194
G L +GA L+ L L N I+ KG LA+A+ ++ ++ L+L +N +G L
Sbjct: 138 GGLAANGA---LQRLDLRNNQ-ISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALM 193
Query: 195 VAVASSRTLEVLDLEGTGL 213
+ S+RTL LDL G +
Sbjct: 194 NCLPSNRTLWRLDLAGNNI 212
Score = 33.5 bits (75), Expect = 0.25
Identities = 51/228 (22%), Positives = 90/228 (39%), Gaps = 15/228 (6%)
Query: 43 RDFGRICRALAGATSLAQLN---------LNLGVVS-SPSRIKQLAEALRTNRSIQSLFL 92
R + R+CR A L L+L S + + L + L L L
Sbjct: 6 RSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVL 65
Query: 93 HGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLS 152
L++ G LL L + L LDL L + LL + ++ LTL
Sbjct: 66 SDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQN---KSIQSLTLE 122
Query: 153 ANP-GITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGT 211
N G ++ +A + ++ L+L N + A LA+A+ + TL+ LDL
Sbjct: 123 WNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWN 182
Query: 212 GLTNQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICDLLSEGEE 259
+ + L++ + + T R L LA N+I ++ + + + ++
Sbjct: 183 NVGLLGGRALMNCLPSNRTLWR-LDLAGNNIPGDVLRAVEQAMGHSQD 229
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 48.9 bits (115), Expect = 6e-06
Identities = 68/259 (26%), Positives = 114/259 (44%), Gaps = 19/259 (7%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRL--LSLRGCRLCDRDFGRICRALAGATSLAQLNL 63
+ +SG + + +C GLR RL + LR C+L + L L +L+L
Sbjct: 775 MDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDL 834
Query: 64 NLGVVSSPSRIKQLAEALRTNRS-IQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
G ++ L + LR +++L+L LT A L L+++ +L LDL
Sbjct: 835 T-GNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSL 893
Query: 123 CMLGDEAINLIC-GLLPP----DGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVRV 177
LGD + L+C GL P + G+ L +A G L++ + + +R
Sbjct: 894 NELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEG--------LSVVLQANHNLRE 945
Query: 178 LNLDYNPLGDHVAGMLAVAVA-SSRTLEVLDLEGTGLTNQSAQTLLDMVENYPTALRSLV 236
L+L +N LGD +LA + + L+ L L+ GLT ++ + L + T L L
Sbjct: 946 LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQT-LTDLY 1004
Query: 237 LAENSISPELQQQICDLLS 255
L N++ + +C LS
Sbjct: 1005 LTNNALGDTGVRLLCKRLS 1023
Score = 34.3 bits (77), Expect = 0.15
Identities = 39/141 (27%), Positives = 59/141 (41%), Gaps = 4/141 (2%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLRG--CRLCDRDFGRICRALAGATSLAQLNL 63
+ +S L V +C GLR +L +LR CRL + L +L +L+L
Sbjct: 889 LDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDL 948
Query: 64 NLGVVSSPSRIKQLAEALRTNRS-IQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ + + LAE L+ +Q L+L LT L L ++ L L L +
Sbjct: 949 SFNDLGDWG-LWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTN 1007
Query: 123 CMLGDEAINLICGLLPPDGAK 143
LGD + L+C L G K
Sbjct: 1008 NALGDTGVRLLCKRLSHPGCK 1028
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 48.5 bits (114), Expect = 8e-06
Identities = 48/153 (31%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLR--GCRLCDRDFGRICRALAGATSLAQLNL 63
+ +SG LS + V+ +C+ LR L +LR GC L D + L +L +L+L
Sbjct: 813 LDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL 872
Query: 64 NLGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ V++ K L + LR + +Q L L LT L L+ P+L LDL
Sbjct: 873 SFNVLTDAGA-KHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQ 931
Query: 123 CMLGDEAINLIC-GLLPP--DGAKSGLKELTLS 152
L D + L+C GL P + GL + TLS
Sbjct: 932 NNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/158 (27%), Positives = 68/158 (43%), Gaps = 5/158 (3%)
Query: 96 PLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANP 155
P+TDA +L L + L LDL L A+ +C L L E A
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---LLETLRLAGC 847
Query: 156 GITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVAS-SRTLEVLDLEGTGLT 214
G+T + LA + + + L+L +N L D A L + S L+ L L GLT
Sbjct: 848 GLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLT 907
Query: 215 NQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICD 252
+ Q L ++ P +L+ L L +N++ + +C+
Sbjct: 908 SDCCQDLASVLSASP-SLKELDLQQNNLDDVGVRLLCE 944
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 48.5 bits (114), Expect = 8e-06
Identities = 48/153 (31%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLR--GCRLCDRDFGRICRALAGATSLAQLNL 63
+ +SG LS + V+ +C+ LR L +LR GC L D + L +L +L+L
Sbjct: 813 LDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL 872
Query: 64 NLGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ V++ K L + LR + +Q L L LT L L+ P+L LDL
Sbjct: 873 SFNVLTDAGA-KHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQ 931
Query: 123 CMLGDEAINLIC-GLLPP--DGAKSGLKELTLS 152
L D + L+C GL P + GL + TLS
Sbjct: 932 NNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/158 (27%), Positives = 68/158 (43%), Gaps = 5/158 (3%)
Query: 96 PLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANP 155
P+TDA +L L + L LDL L A+ +C L L E A
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---LLETLRLAGC 847
Query: 156 GITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVAS-SRTLEVLDLEGTGLT 214
G+T + LA + + + L+L +N L D A L + S L+ L L GLT
Sbjct: 848 GLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLT 907
Query: 215 NQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICD 252
+ Q L ++ P +L+ L L +N++ + +C+
Sbjct: 908 SDCCQDLASVLSASP-SLKELDLQQNNLDDVGVRLLCE 944
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 48.5 bits (114), Expect = 8e-06
Identities = 48/153 (31%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLR--GCRLCDRDFGRICRALAGATSLAQLNL 63
+ +SG LS + V+ +C+ LR L +LR GC L D + L +L +L+L
Sbjct: 813 LDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL 872
Query: 64 NLGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ V++ K L + LR + +Q L L LT L L+ P+L LDL
Sbjct: 873 SFNVLTDAGA-KHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQ 931
Query: 123 CMLGDEAINLIC-GLLPP--DGAKSGLKELTLS 152
L D + L+C GL P + GL + TLS
Sbjct: 932 NNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/158 (27%), Positives = 68/158 (43%), Gaps = 5/158 (3%)
Query: 96 PLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANP 155
P+TDA +L L + L LDL L A+ +C L L E A
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---LLETLRLAGC 847
Query: 156 GITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVAS-SRTLEVLDLEGTGLT 214
G+T + LA + + + L+L +N L D A L + S L+ L L GLT
Sbjct: 848 GLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLT 907
Query: 215 NQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICD 252
+ Q L ++ P +L+ L L +N++ + +C+
Sbjct: 908 SDCCQDLASVLSASP-SLKELDLQQNNLDDVGVRLLCE 944
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 47.8 bits (112), Expect = 1e-05
Identities = 55/173 (31%), Positives = 76/173 (43%), Gaps = 6/173 (3%)
Query: 29 AVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEAL-RTNRSI 87
A+ L L C+L + AL SL LNL+ + +K L EAL R + ++
Sbjct: 868 ALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEG-VKFLCEALGRPDGNL 926
Query: 88 QSLFLHGSPLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLK 147
QSL L G T G L AL+ + + LDLG+ L D+ + L+C L P A L
Sbjct: 927 QSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRA---LH 983
Query: 148 ELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASS 200
L L A +T L ++ S + LNL N L ML A+ S
Sbjct: 984 TLGL-AKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKS 1035
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/138 (31%), Positives = 64/138 (46%), Gaps = 5/138 (3%)
Query: 6 IQISGEPLSGAEVRDICRGLRDNAVRLLSLR--GCRLCDRDFGRICRALAGATSLAQLNL 63
+ +SG LS + V+ +C+ LR L +LR GC L D + L +L +L+L
Sbjct: 813 LDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL 872
Query: 64 NLGVVSSPSRIKQLAEALRT-NRSIQSLFLHGSPLTDAGLALLNPALALHPALVALDLGD 122
+ V++ K L + LR + +Q L L LT L L+ P+L LDL
Sbjct: 873 SFNVLTDAGA-KHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQ 931
Query: 123 CMLGDEAINLIC-GLLPP 139
L D + L+C GL P
Sbjct: 932 NNLDDVGVRLLCEGLRHP 949
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/158 (27%), Positives = 68/158 (43%), Gaps = 5/158 (3%)
Query: 96 PLTDAGLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANP 155
P+TDA +L L + L LDL L A+ +C L L E A
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC---LLETLRLAGC 847
Query: 156 GITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVAS-SRTLEVLDLEGTGLT 214
G+T + LA + + + L+L +N L D A L + S L+ L L GLT
Sbjct: 848 GLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLT 907
Query: 215 NQSAQTLLDMVENYPTALRSLVLAENSISPELQQQICD 252
+ Q L ++ P +L+ L L +N++ + +C+
Sbjct: 908 SDCCQDLASVLSASP-SLKELDLQQNNLDDVGVRLLCE 944
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,100,817
Number of Sequences: 37866
Number of extensions: 538228
Number of successful extensions: 2331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 1988
Number of HSP's gapped (non-prelim): 202
length of query: 316
length of database: 18,247,518
effective HSP length: 102
effective length of query: 214
effective length of database: 14,385,186
effective search space: 3078429804
effective search space used: 3078429804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.