Search of human proteins with 6005762

Search of human proteins with 6005762

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6005762 frizzled 10 [Homo sapiens]
         (581 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6005762 frizzled 10 [Homo sapiens]                                1218   0.0  
gi|4503835 frizzled 9 [Homo sapiens]                                  775   0.0  
gi|22547161 frizzled 4 [Homo sapiens]                                 552   e-157
gi|4503825 frizzled 1 [Homo sapiens]                                  498   e-141
gi|4503833 frizzled 7 [Homo sapiens]                                  493   e-139
gi|4503827 frizzled 2 [Homo sapiens]                                  487   e-137
gi|27894385 frizzled 5 precursor [Homo sapiens]                       486   e-137
gi|13994190 frizzled 8 [Homo sapiens]                                 472   e-133
gi|8393378 frizzled 3 [Homo sapiens]                                  374   e-103
gi|34734079 frizzled 6 [Homo sapiens]                                 368   e-102
gi|5032099 smoothened [Homo sapiens]                                  163   4e-40
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      113   4e-25
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]       105   9e-23
gi|38455388 frizzled-related protein [Homo sapiens]                   105   1e-22
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...   104   3e-22
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]        101   2e-21
gi|29244926 corin [Homo sapiens]                                      100   4e-21
gi|13899255 membrane frizzled-related protein [Homo sapiens]           73   6e-13
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      70   5e-12
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                65   1e-10
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    51   3e-06
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]    37   0.050
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [...    36   0.11 
gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens]    36   0.11 
gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapi...    36   0.11 
gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]    34   0.42 
gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]    34   0.42 
gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]    34   0.42 
gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]    34   0.42 
gi|93204873 G protein-coupled receptor 157 [Homo sapiens]              34   0.42 

>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score = 1218 bits (3151), Expect = 0.0
 Identities = 581/581 (100%), Positives = 581/581 (100%)

Query: 1   MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHEN 60
           MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHEN
Sbjct: 1   MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHEN 60

Query: 61  QREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPI 120
           QREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPI
Sbjct: 61  QREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPI 120

Query: 121 MEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEH 180
           MEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEH
Sbjct: 121 MEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEH 180

Query: 181 PLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF 240
           PLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF
Sbjct: 181 PLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF 240

Query: 241 SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI 300
           SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI
Sbjct: 241 SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI 300

Query: 301 QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA 360
           QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA
Sbjct: 301 QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA 360

Query: 361 IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL 420
           IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL
Sbjct: 361 IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL 420

Query: 421 FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK 480
           FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK
Sbjct: 421 FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK 480

Query: 481 CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLK 540
           CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLK
Sbjct: 481 CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLK 540

Query: 541 KKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV 581
           KKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
Sbjct: 541 KKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV 581


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  775 bits (2001), Expect = 0.0
 Identities = 370/564 (65%), Positives = 445/564 (78%), Gaps = 18/564 (3%)

Query: 8   LWLVLQVMGSCAAISSMDMERP-GDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAI 66
           LW +L   G+   I   D ER  G   CQ +EIPMC+ IGYN+TRMPNL+GH +Q EAA 
Sbjct: 12  LWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAA 71

Query: 67  QLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNF 126
           +L EFAPLV+YGCH HLRFFLCSLYAPMCT+QVSTPIPACR MCEQARL+C+PIMEQFNF
Sbjct: 72  ELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNF 131

Query: 127 KWPDSLDCRKLPNKNDPNYLCMEAPNN---GSDEPTRGSGLFPPLFRPQRPHSAQEHPLK 183
            WPDSLDC +LP +NDP+ LCMEAP N   G  EP +G G+ P   RP RP         
Sbjct: 132 GWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPG------- 184

Query: 184 DGGPGRGG---CDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF 240
           D GPG GG   C+NP KF +VEKS SCAP C PGV+V+WSR DK FA+VW+A+W+ LCFF
Sbjct: 185 DLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFF 244

Query: 241 SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI 300
           S+AFTVLTFL++P RF+YPERPIIFLSMCY VYS+ +LIR  AGA+S+ACD+++G LYVI
Sbjct: 245 STAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVI 304

Query: 301 QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA 360
           QEGLE+TGCTLVFL+LYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEA+ SYFH+AAW 
Sbjct: 305 QEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWG 364

Query: 361 IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL 420
           +PA+KTI+IL +R+VAGDELTG+CYV S D  ALTGFVL+PL+ YLV+G+SF+L+GFVAL
Sbjct: 365 LPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVAL 424

Query: 421 FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK 480
           FHIR++MKTGG NT+KLEKLMV+IG+FS+LYTVPATCVI CY YERLNMD+W++ A +  
Sbjct: 425 FHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQP 484

Query: 481 C-KMNNQTKTLDC-LMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRR 538
           C          DC L   S+P V +FM+KIFM LVVGITSG+W+W+SKT Q+WQ +C R+
Sbjct: 485 CAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRK 544

Query: 539 LKKKSRRKPASVITSGGIYKKAQH 562
           +   + R  A    + G Y +  H
Sbjct: 545 I--AAGRARAKACRAPGSYGRGTH 566


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  552 bits (1422), Expect = e-157
 Identities = 276/515 (53%), Positives = 360/515 (69%), Gaps = 41/515 (7%)

Query: 33  KCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYA 92
           +C PI I MC+++GYN+T+MPNL+GHE Q +A +QL  F PL++YGC   L+FFLCS+Y 
Sbjct: 44  RCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYV 103

Query: 93  PMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPN 152
           PMCTE+++ PI  C  MC   + +C P++++F F WP+SL+C K P +ND N++CME P 
Sbjct: 104 PMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGP- 162

Query: 153 NGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCT 212
            G +E         PL     PH     P++ G        N  ++  V++S +C   C 
Sbjct: 163 -GDEEV--------PL-----PHKT---PIQPGEECHSVGTNSDQYIWVKRSLNCVLKCG 205

Query: 213 PGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCV 272
               +Y SR  K F  +W+A+WA LCF S+AFTVLTFLID +RF YPERPIIFLSMCY +
Sbjct: 206 YDAGLY-SRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNI 264

Query: 273 YSVGYLIRLFAGAESIACD-RDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLT 331
           YS+ Y++RL  G E I+CD  ++ +  +IQEGL++TGC ++FL++Y+FGMASS+WWV+LT
Sbjct: 265 YSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILT 324

Query: 332 LTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDV 391
           LTWFLAAG KWGHEAIE +SSYFH+AAWAIPAVKTI+IL+MR V  DELTG+CYVG+ ++
Sbjct: 325 LTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNL 384

Query: 392 NALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLY 451
           +ALTGFV+ PL  YLVIGT FI +G VALF IR  ++  G  TDKLE+LMV+IG+FSVLY
Sbjct: 385 DALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLY 444

Query: 452 TVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFML 511
           TVPATCVIACYFYE  N   ++  A                    S  AVE  M+KIFM 
Sbjct: 445 TVPATCVIACYFYEISNWALFRYSADD------------------SNMAVE--MLKIFMS 484

Query: 512 LVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRK 546
           L+VGITSGMWIW++KTL +WQ+ CS RL    + K
Sbjct: 485 LLVGITSGMWIWSAKTLHTWQK-CSNRLVNSGKVK 518


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  498 bits (1282), Expect = e-141
 Identities = 262/543 (48%), Positives = 336/543 (61%), Gaps = 41/543 (7%)

Query: 29  PGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLC 88
           P  G CQPI IP+C DI YN T MPNL+GH NQ +A +++H+F PLV+  C   L+FFLC
Sbjct: 111 PDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLC 170

Query: 89  SLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCM 148
           S+YAP+CT  +   +P CR +CE+AR  C  +M +F F+WPD+L C K P  +    LC+
Sbjct: 171 SMYAPVCTV-LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP-VHGAGELCV 228

Query: 149 EAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKF---------- 198
               N SD+ T    L P  +     H    H  + G PG  G    GKF          
Sbjct: 229 G--QNTSDKGTPTPSLLPEFWTSNPQHGGGGH--RGGFPGGAGASERGKFSCPRALKVPS 284

Query: 199 ---HHVEKSASCAPLCTP----GVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLI 251
              +H      C   C P    G+ +Y+  E+ RF+  W+ IW+VLC  S+ FTVLT+L+
Sbjct: 285 YLNYHFLGEKDCGAPCEPTKVYGL-MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLV 343

Query: 252 DPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDR--DSGQLYVIQEGLESTGC 309
           D  RF YPERPIIFLS CY   +V Y+         +  D+  + G   V Q G +  GC
Sbjct: 344 DMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQ-GTKKEGC 402

Query: 310 TLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILI 369
           T++F++LY+F MASS+WWV+L+LTWFLAAG KWGHEAIEANS YFHLAAWA+PA+KTI I
Sbjct: 403 TILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITI 462

Query: 370 LVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKT 429
           L + +V GD L+GVC+VG  +V+AL GFVL PL  YL IGTSF+L+GFV+LF IR +MK 
Sbjct: 463 LALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH 522

Query: 430 GGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKT 489
            G  T+KLEKLMVRIG+FSVLYTVPAT VIACYFYE+   D W+       CK    +  
Sbjct: 523 DGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCK----SYA 578

Query: 490 LDC--LMAAS--------IPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRL 539
           + C  L A           P   +FM+K  M L+VGITSG WIW+ KTL SW++  +R  
Sbjct: 579 IPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLT 638

Query: 540 KKK 542
             K
Sbjct: 639 NSK 641


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  493 bits (1269), Expect = e-139
 Identities = 259/552 (46%), Positives = 343/552 (62%), Gaps = 30/552 (5%)

Query: 10  LVLQVMGSCAAISSMD-------MERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQR 62
           LVL ++G+ +A +          +  P  G CQPI IP+C DI YN T +PNL+GH NQ 
Sbjct: 18  LVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQE 77

Query: 63  EAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIME 122
           +A +++H+F PLV+  C   LRFFLCS+YAP+CT  +   IP CR +CE+AR  C  +M 
Sbjct: 78  DAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LDQAIPPCRSLCERARQGCEALMN 136

Query: 123 QFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPL-FRPQRPHSAQEHP 181
           +F F+WP+ L C   P          +  ++GS  P  G   +P   + P  P +A    
Sbjct: 137 KFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPG 196

Query: 182 LKDGGPGRGG----CDNPGKF-----HHVEKSASCAPLCTPGVD---VYWSREDKRFAVV 229
             DG  GR      C    K      +       C   C PG     +Y+  E++RFA +
Sbjct: 197 ASDGR-GRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARL 255

Query: 230 WLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIA 289
           W+ +W+VLC  S+ FTVLT+L+D  RF YPERPIIFLS CY + +V ++        ++ 
Sbjct: 256 WVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVC 315

Query: 290 CDRDSGQLY-VIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIE 348
            +R S   Y  + +G +  GCT++F+VLY+FGMASS+WWV+L+LTWFLAAG KWGHEAIE
Sbjct: 316 VERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIE 375

Query: 349 ANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVI 408
           ANS YFHLAAWA+PAVKTI IL M +V GD L+GVCYVG   V+AL GFVL PL  YL I
Sbjct: 376 ANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFI 435

Query: 409 GTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLN 468
           GTSF+L+GFV+LF IR +MK  G  T+KLEKLMVRIG+FSVLYTVPAT V+ACYFYE+  
Sbjct: 436 GTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAF 495

Query: 469 MDYWKILAAQHKCKMNNQTKTLDC---LMAASIPAVEIFMVKIFMLLVVGITSGMWIWTS 525
            ++W+       CK    +  + C         P   +FM+K  M ++VGIT+G WIW+ 
Sbjct: 496 REHWERTWLLQTCK----SYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGITTGFWIWSG 551

Query: 526 KTLQSWQQVCSR 537
           KTLQSW++   R
Sbjct: 552 KTLQSWRRFYHR 563


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  487 bits (1253), Expect = e-137
 Identities = 260/555 (46%), Positives = 343/555 (61%), Gaps = 42/555 (7%)

Query: 10  LVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLH 69
           L+L   G         +  P  G CQPI IP+C DI YN T MPNL+GH NQ +A +++H
Sbjct: 15  LLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVH 74

Query: 70  EFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWP 129
           +F PLV+  C   LRFFLCS+YAP+CT  +   IP CR +CE+AR  C  +M +F F+WP
Sbjct: 75  QFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGCEALMNKFGFQWP 133

Query: 130 DSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGR 189
           + L C   P ++    +C+   ++    P   +   PP  +P     A   P   GGPG 
Sbjct: 134 ERLRCEHFP-RHGAEQICVGQNHSEDGAPALLTTAPPPGLQP----GAGGTP---GGPGG 185

Query: 190 GGC-------DNPGKFHHVEKSAS-----------CAPLCTPGV---DVYWSREDKRFAV 228
           GG        ++P     V K  S           CA  C P      +++S+E+ RFA 
Sbjct: 186 GGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFAR 245

Query: 229 VWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESI 288
           +W+  W+VLC  S+ FTV T+L+D  RFRYPERPIIFLS CY + SV Y+   F   E +
Sbjct: 246 LWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAG-FVLQERV 304

Query: 289 ACDR---DSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHE 345
            C+    + G   V+Q G +  GCT++F++LY+F MASS+WWV+L+LTWFLAAG KWGHE
Sbjct: 305 VCNERFSEDGYRTVVQ-GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHE 363

Query: 346 AIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACY 405
           AIEANS YFHLAAWA+PAVKTI IL M ++ GD L+GVC+VG   ++ L GFVL PL  Y
Sbjct: 364 AIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVY 423

Query: 406 LVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYE 465
           L IGTSF+L+GFV+LF IR +MK  G  T+KLE+LMVRIG+FSVLYTVPAT VIACYFYE
Sbjct: 424 LFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYE 483

Query: 466 RLNMDYWKILAAQHKCKMNNQTKTLDC---LMAASIPAVEIFMVKIFMLLVVGITSGMWI 522
           +   ++W+       CK    +  + C         P   ++M+K  M L+VGITSG WI
Sbjct: 484 QAFREHWERSWVSQHCK----SLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWI 539

Query: 523 WTSKTLQSWQQVCSR 537
           W+ KTL SW++  +R
Sbjct: 540 WSGKTLHSWRKFYTR 554


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  486 bits (1252), Expect = e-137
 Identities = 260/582 (44%), Positives = 352/582 (60%), Gaps = 45/582 (7%)

Query: 1   MQRPGPR------LWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPN 54
           M RP P       L L+ Q++G  AA S   +       CQ I +PMC+ IGYN+T MPN
Sbjct: 1   MARPDPSAPPSLLLLLLAQLVGRAAAASKAPV-------CQEITVPMCRGIGYNLTHMPN 53

Query: 55  LMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQAR 114
              H+ Q EA +++H+F PLVE  C   LRFFLCS+Y P+C      P+P CR +CE+A+
Sbjct: 54  QFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAK 113

Query: 115 LKCSPIMEQFNFKWPDSLDCRKLPNKN-DPNYLCMEAPNNGSDEPTRGSGLFP--PLFR- 170
             CSP+M Q+ F WP+ + C +LP    D   LCM+   N S+  T     FP  P    
Sbjct: 114 AGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDY--NRSEATTAPPRPFPAKPTLPG 171

Query: 171 -PQRPHSAQEHPLKDGGPGRGGCDNP--------GKFHHVEKSASCAPLCTPGVDVYWSR 221
            P  P S  E P   GGP    C  P           ++  ++        P     +S 
Sbjct: 172 PPGAPASGGECPA--GGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSA 229

Query: 222 EDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRL 281
           +++ FA  W+ +W+VLCF S++ TV TFLID  RFRYPERPIIFLS CY   S+G+L+RL
Sbjct: 230 DERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRL 289

Query: 282 FAGAESIACDRDSGQLYVIQEGLESTG---CTLVFLVLYYFGMASSLWWVVLTLTWFLAA 338
             G  S+AC R+   ++      E+TG   CT+VFL++Y+FGMASS+WWV+L+LTWFLAA
Sbjct: 290 VVGHASVACSREHNHIHY-----ETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAA 344

Query: 339 GKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFV 398
           G KWG+EAI   + YFHLAAW IP+VK+I  L +  V GD + G+CYVG+ ++N+L GFV
Sbjct: 345 GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFV 404

Query: 399 LIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCV 458
           L PL  YL++GT F+L+GFV+LF IR V+K GG  TDKLEKLM+RIG+F++LYTVPA+ V
Sbjct: 405 LGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIV 464

Query: 459 IACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITS 518
           +ACY YE+   + W+   A   C         D     + P   + M+K FM LVVGITS
Sbjct: 465 VACYLYEQHYRESWE---AALTCACPGH----DTGQPRAKPEYWVLMLKYFMCLVVGITS 517

Query: 519 GMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKA 560
           G+WIW+ KT++SW++  SR   +  R   +    + G Y +A
Sbjct: 518 GVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYPEA 559


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  472 bits (1215), Expect = e-133
 Identities = 260/617 (42%), Positives = 352/617 (57%), Gaps = 105/617 (17%)

Query: 11  VLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHE 70
           +LQ     AA S+ ++       CQ I +P+CK IGYN T MPN   H+ Q EA +++H+
Sbjct: 18  LLQRSSGAAAASAKELA------CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQ 71

Query: 71  FAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPD 130
           F PLVE  C   L+FFLCS+Y P+C E    P+P CR +CE+A+  C+P+M Q+ F WPD
Sbjct: 72  FWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPD 131

Query: 131 SLDCRKLPNKNDPNYLCME-----------------APNNGSDEPTRGSGLF-PPLFRPQ 172
            + C +LP + +P+ LCM+                  P    ++P  GSG   PP  RP 
Sbjct: 132 RMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARP- 190

Query: 173 RPH----------SAQEHPLKDGG-------PGRGGCD-NPG---------------KFH 199
            PH           A   P + GG       PG G     PG                 +
Sbjct: 191 -PHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLY 249

Query: 200 HVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYP 259
           +  K+   A    P  + ++S++++ F V W+ +W+VLCF S+  TV TFLID  RF+YP
Sbjct: 250 NRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYP 309

Query: 260 ERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSG------------------------ 295
           ERPIIFLS CY   SVGYL+RL AG E +AC   +                         
Sbjct: 310 ERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGG 369

Query: 296 --------QLYVIQEGL--ESTG---CTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKW 342
                   +L  +++ +  E+TG   CT+VFL++Y+FGMASS+WWV+L+LTWFLAAG KW
Sbjct: 370 PGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKW 429

Query: 343 GHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPL 402
           G+EAI   S YFHLAAW +P+VK+I +L +  V GD + G+CYVG+  ++ L GFVL PL
Sbjct: 430 GNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPL 489

Query: 403 ACYLVIGTSFILSGFVALFHIRRVMK--TGGENTDKLEKLMVRIGLFSVLYTVPATCVIA 460
             YL IGT F+L+GFV+LF IR V+K   G   T KLEKLM+R+GLF+VLYTVPA  V+A
Sbjct: 490 VIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVA 549

Query: 461 CYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGM 520
           C FYE+ N   W+   A H C      +       A  P   +FM+K FM LVVGITSG+
Sbjct: 550 CLFYEQHNRPRWE---ATHNCPCLRDLQP----DQARRPDYAVFMLKYFMCLVVGITSGV 602

Query: 521 WIWTSKTLQSWQQVCSR 537
           W+W+ KTL+SW+ +C+R
Sbjct: 603 WVWSGKTLESWRSLCTR 619


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  374 bits (961), Expect = e-103
 Identities = 200/515 (38%), Positives = 299/515 (58%), Gaps = 30/515 (5%)

Query: 34  CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93
           C+PI + MC+D+ YN T MPNL+ H +Q+ AA+ +  F P+V   C    R FLC+LYAP
Sbjct: 28  CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87

Query: 94  MCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNN 153
           +C E     +P CR +C++A  +CS +ME F   WP+ ++C + P+ ++P    ++   N
Sbjct: 88  ICMEYGRVTLP-CRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDL--N 144

Query: 154 GSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTP 213
            + EPT G+ +       QR +           P  G       F HV     C+P C  
Sbjct: 145 LAGEPTEGAPV-----AVQRDYGFWCPRELKIDPDLGY-----SFLHVR---DCSPPCP- 190

Query: 214 GVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVY 273
             ++Y+ RE+  FA  ++ + +++C  ++ FT LTFLID  RFRYPERPIIF ++CY + 
Sbjct: 191 --NMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMV 248

Query: 274 SVGYLIRLFAGAESIACDRDSGQLY---VIQEGLESTGCTLVFLVLYYFGMASSLWWVVL 330
           S+ + I  F   + +AC+      Y    + +G  +  CT++F++LY+F MA S+WWV+L
Sbjct: 249 SLIFFIG-FLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVIL 307

Query: 331 TLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMD 390
           T+TWFLAA  KWG EAIE  +  FH +AW IP   TI++L M ++ GD ++GVC+VG  D
Sbjct: 308 TITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYD 367

Query: 391 VNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL 450
           V+AL  FVL PL  Y+V+G S +L+G ++L  +R  +    EN DKL K M+RIG+FS+L
Sbjct: 368 VDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSIL 427

Query: 451 YTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDC---LMAASIPAVEIFMVK 507
           Y VP   VI CYFYE+     W+    Q +C+  +    + C   +   S P + +F++K
Sbjct: 428 YLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYH----IPCPYQVTQMSRPDLILFLMK 483

Query: 508 IFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKK 542
             M L+VGI S  W+ + KT   W      R KK+
Sbjct: 484 YLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE 518


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score =  368 bits (944), Expect = e-102
 Identities = 193/555 (34%), Positives = 307/555 (55%), Gaps = 44/555 (7%)

Query: 34  CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93
           C+PI +P C  + YNMT  PNLMGH +Q  AA+++  F PL    C  ++  FLC  + P
Sbjct: 24  CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83

Query: 94  MCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKL-------PNKNDPNYL 146
            C EQ+   +P CR +CE+    C  +++ F  +WP+ L+C +L       P   DP+  
Sbjct: 84  TCIEQIHV-VPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTE 142

Query: 147 CMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSAS 206
            +  P   +++  R  G + P            H    GG G        KF  +++   
Sbjct: 143 FL-GPQKKTEQVQRDIGFWCP-----------RHLKTSGGQGY-------KFLGIDQ--- 180

Query: 207 CAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFL 266
           CAP C    ++Y+  ++  FA  ++   ++ C  ++ FT LTFLID  RFRYPERPII+ 
Sbjct: 181 CAPPCP---NMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYY 237

Query: 267 SMCYCVYSVGYLIRLFAGAESIACDRDSGQLYV---IQEGLESTGCTLVFLVLYYFGMAS 323
           S+CY + S+ Y I    G +S AC++   +L +   +  G ++  CT++F++LY+F MA 
Sbjct: 238 SVCYSIVSLMYFIGFLLG-DSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAG 296

Query: 324 SLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGV 383
           ++WWV+LT+TWFLAAG+KW  EAIE  + +FH  AW  P   T+++L M +V GD ++GV
Sbjct: 297 TVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGV 356

Query: 384 CYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVR 443
           C+VG  D++A   FVL+PL   + +G S +L+G ++L H+R+V++  G N +KL+K M+R
Sbjct: 357 CFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIR 416

Query: 444 IGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDC---LMAASIPA 500
           IG+FS LY VP   ++ CY YE++N   W+I      C+  +    + C     A + P 
Sbjct: 417 IGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYH----IPCPYQAKAKARPE 472

Query: 501 VEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKA 560
           + +FM+K  M L+VGI++  W+ + KT   W     R  K+    +   V+     +   
Sbjct: 473 LALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLK 532

Query: 561 QHPQKTHHGKYEIPA 575
            + +  H  K+  P+
Sbjct: 533 HNSKVKHKKKHYKPS 547


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score =  163 bits (413), Expect = 4e-40
 Identities = 139/543 (25%), Positives = 234/543 (43%), Gaps = 59/543 (10%)

Query: 34  CQPIEIPMCKD--IGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYG-CHGHLRFFLCSL 90
           C+P+   +C    + Y  T        ++Q EA  +L  ++ L     C   ++  LC++
Sbjct: 70  CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129

Query: 91  YAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEA 150
           Y P C E     +P+ R +C+  R  C+ +  +    WPD L C        P+      
Sbjct: 130 YMPKC-ENDRVELPS-RTLCQATRGPCAIVERERG--WPDFLRCT-------PDRFPEGC 178

Query: 151 PNNGSDEPTRGSGLFP-PLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAP 209
            N   +     SG    PL R   P S  E     G      C NP              
Sbjct: 179 TNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQ----CQNP-------------- 220

Query: 210 LCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARF-RYPERPIIFLSM 268
                    ++  + +    ++A +  +    + FT+ TF+ D     RYP   + +++ 
Sbjct: 221 --------LFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNA 272

Query: 269 CYCVYSVGYLIRLFAGAE-SIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWW 327
           C+ V S+G+L +   GA   I C  D           E+  C ++F+++YY  MA  +W+
Sbjct: 273 CFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWF 332

Query: 328 VVLTLTW---FLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVC 384
           VVLT  W   F A G  +  + +   +SYFHL  W++P V T+ IL + +V GD ++G+C
Sbjct: 333 VVLTYAWHTSFKALGTTY--QPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGIC 390

Query: 385 YVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIR--RVMKTGGENTDKLEKLMV 442
           +VG  +     GFVL P+   L++G  F++ G + LF I+         +   K+ + M+
Sbjct: 391 FVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETML 450

Query: 443 RIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTL-------DCLMA 495
           R+G+F  L         +C+FY+  N   W+     +     N T  L       DC + 
Sbjct: 451 RLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEI- 509

Query: 496 ASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGG 555
            + P++ +  + +F +   GI    W+WT  TL  W++    RL  +S  +P  +  S  
Sbjct: 510 KNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWC-RLTGQSDDEPKRIKKSKM 568

Query: 556 IYK 558
           I K
Sbjct: 569 IAK 571


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  113 bits (283), Expect = 4e-25
 Identities = 52/142 (36%), Positives = 83/142 (58%), Gaps = 1/142 (0%)

Query: 34  CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93
           C+ + IPMC+ + +N+TRMPN + H  Q  A + + ++  LV+  C   LRFFLC++YAP
Sbjct: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83

Query: 94  MCT-EQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPN 152
           +CT E +  PI  C+ +C++AR  C P+M+ +N  WP+SL C +LP  +    +  EA  
Sbjct: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIV 143

Query: 153 NGSDEPTRGSGLFPPLFRPQRP 174
               E  +   + P +   +RP
Sbjct: 144 TDLPEDVKWIDITPDMMVQERP 165


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score =  105 bits (263), Expect = 9e-23
 Identities = 45/107 (42%), Positives = 64/107 (59%), Gaps = 3/107 (2%)

Query: 36  PIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMC 95
           P ++P+C  +GY   R+PNL+ HE+  E   Q   + PL+   CH   + FLCSL+AP+C
Sbjct: 57  PADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC 116

Query: 96  TEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKND 142
            ++   PI  CR +CE  R  C+P+ME + F WP+ L C K P  ND
Sbjct: 117 LDR---PIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDND 160


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  105 bits (261), Expect = 1e-22
 Identities = 44/106 (41%), Positives = 68/106 (64%), Gaps = 1/106 (0%)

Query: 34  CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93
           C+P+ IP+CK + +NMT+MPN + H  Q  A + + +F  L+   C   L FFLC++YAP
Sbjct: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94

Query: 94  MCT-EQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLP 138
           +CT +    PI  C+ +CE+AR  C PI+ ++   WP++L C +LP
Sbjct: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score =  104 bits (259), Expect = 3e-22
 Identities = 45/111 (40%), Positives = 64/111 (57%), Gaps = 2/111 (1%)

Query: 34  CQPI--EIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLY 91
           C+PI   + +C  I Y   R+PNL+GHE  +E   Q   + PLV   CH   + FLCSL+
Sbjct: 40  CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99

Query: 92  APMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKND 142
           AP+C + +   I  C  +C Q + +C+P+M  F F WPD L+C + P  ND
Sbjct: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDND 150


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score =  101 bits (251), Expect = 2e-21
 Identities = 49/145 (33%), Positives = 74/145 (51%), Gaps = 5/145 (3%)

Query: 36  PIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMC 95
           P ++ +C ++GY    +PNL+ HE   E   Q   + PL+   CH   + FLCSL+AP+C
Sbjct: 62  PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121

Query: 96  TEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGS 155
            ++   PI  CR +CE  R  C P+M+ F F WP+ L C K P  +    + M  PN   
Sbjct: 122 LDR---PIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGD--VCIAMTPPNATE 176

Query: 156 DEPTRGSGLFPPLFRPQRPHSAQEH 180
               +G+ + PP     +  +  EH
Sbjct: 177 ASKPQGTTVCPPCDNELKSEAIIEH 201


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  100 bits (249), Expect = 4e-21
 Identities = 40/118 (33%), Positives = 64/118 (54%), Gaps = 2/118 (1%)

Query: 33  KCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHE--FAPLVEYGCHGHLRFFLCSL 90
           +C+PI + +C ++ YN T  PN  GH  Q+EA+I      F  LV+  C+ +L FF C++
Sbjct: 454 QCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTI 513

Query: 91  YAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCM 148
             P C       IP CR +CE ++ +C  ++     +WP+  DC + P +N  N  C+
Sbjct: 514 LVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCL 571



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 37/126 (29%), Positives = 51/126 (40%), Gaps = 9/126 (7%)

Query: 25  DMERPGD------GKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYG 78
           D   PGD        C  I    C+ + Y+ T  P L    N  E    L  F  L    
Sbjct: 124 DASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNM-EMEKFLKFFTYLHRLS 182

Query: 79  CHGHLRFFLCSLYAPMCT--EQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRK 136
           C+ H+  F C+L  P C      S  +  CR  CE A+  C  ++   N+ WPD L C +
Sbjct: 183 CYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQ 242

Query: 137 LPNKND 142
             N+ +
Sbjct: 243 FRNQTE 248


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 4/115 (3%)

Query: 29  PGDGKCQPIEIPMCKDIGYNMTRMPNL-MGHENQREAAIQLHEFAPLVEYGCHGHLRFFL 87
           P +  C+P+++ MC  + YN T  PN+ +G   Q E    L  +  L    C+ H R  L
Sbjct: 461 PPELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLL 520

Query: 88  CSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKND 142
           C L  P CT  + + +P CR +C++A  +C   +      WP   +C +LP   D
Sbjct: 521 CGLLVPRCT-PLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEAAD 572


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 55/180 (30%), Positives = 75/180 (41%), Gaps = 10/180 (5%)

Query: 4   PGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQR- 62
           P P   L+L V+   AA    + ER     C  +++  C D  YN T  PNL+ H +   
Sbjct: 2   PPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEV 61

Query: 63  -EAA---IQLHEFAPLVEYGCHGHLRFFLCSLYAPMCT-EQVSTPIPACRVMCEQARLKC 117
            EA+   I L     L+E  C+  LR   C++ AP C    V  P   CR +CE  R  C
Sbjct: 62  VEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRP---CRHICEGLREVC 118

Query: 118 SPIMEQFNFKWPDSLDCRKLPNKNDPN-YLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHS 176
            P  +  +  WP  LDC +   + D   Y  +E    G +         PP F     HS
Sbjct: 119 QPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHS 178


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 21/191 (10%)

Query: 4   PGPRLWLVLQVMGSCAAISSMDMERPGDGKCQ-----------PIEIPMCKDIGYNMTRM 52
           P P   L+L V+   AA    + ER   G+C             +++  C D  YN T  
Sbjct: 2   PPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTF 61

Query: 53  PNLMGHENQR--EAA---IQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQ-VSTPIPAC 106
           PNL+ H +    EA+   I L     L+E  C+  LR   C++ AP C    V  P   C
Sbjct: 62  PNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRP---C 118

Query: 107 RVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPN-YLCMEAPNNGSDEPTRGSGLF 165
           R +CE  R  C P  +  +  WP  LDC +   + D   Y  +E    G +         
Sbjct: 119 RHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGL 178

Query: 166 PPLFRPQRPHS 176
           PP F     HS
Sbjct: 179 PPTFIRFSHHS 189


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 3/101 (2%)

Query: 19  AAISSMDMERPGDGKCQPI--EIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVE 76
           +A+   D E P  G+C P+   +P+C  +G +   +PN + HE+  +       +  L++
Sbjct: 320 SALLGADPEAPA-GRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQ 378

Query: 77  YGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKC 117
             CH  L +F C L  P C        P C   CE  +  C
Sbjct: 379 THCHPFLAWFFCLLLVPPCGSVPPPAPPPCCQFCEALQDAC 419


>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
          Length = 6306

 Score = 37.0 bits (84), Expect = 0.050
 Identities = 28/120 (23%), Positives = 52/120 (43%), Gaps = 14/120 (11%)

Query: 304  LESTGCTLVFLVLYYFGMASSLWWVVLTLT-WFLAAGKKWGHEAIEANSSYFHLAAWAIP 362
            L    C+ +  V +Y  +    W ++ ++  W++        E  E     F L +W +P
Sbjct: 5965 LAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV---MNDEHTERRYLLFFLLSWGLP 6021

Query: 363  AVKTILILV---------MRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFI 413
            A   IL++V         M ++ G     +C++ ++   AL    L+PL C +V+   FI
Sbjct: 6022 AFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPNV-YAALFTAALVPLTCLVVVFVVFI 6080


>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
            sapiens]
          Length = 1584

 Score = 35.8 bits (81), Expect = 0.11
 Identities = 43/174 (24%), Positives = 70/174 (40%), Gaps = 27/174 (15%)

Query: 238  CFFSSAFTVLTFLIDPARFRY--PERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSG 295
            C  SS   ++  +I  + +RY   ER +I ++ C  + S   LI +             G
Sbjct: 955  CGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILI-------------G 1001

Query: 296  QLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTW--FLAAGKKWGHEAIEANSSY 353
            Q     + +    CTLV   L++F ++S  W  VLT  W  ++A     GH         
Sbjct: 1002 QTQTRNKVV----CTLVAAFLHFFFLSSFCW--VLTEAWQSYMAV---TGHLRNRLIRKR 1052

Query: 354  FHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLV 407
            F    W +PA+   + +   +  G      C++ S++   L  FV    A  LV
Sbjct: 1053 FLCLGWGLPALVVAISVGFTKAKGYSTMNYCWL-SLEGGLLYAFVGPAAAVVLV 1105


>gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens]
          Length = 870

 Score = 35.8 bits (81), Expect = 0.11
 Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 6/98 (6%)

Query: 308 GCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTI 367
           G  LVF++LY    ++ LW  +L ++ FL   +    E ++       ++ W IPA+   
Sbjct: 442 GQILVFVLLYSSLYSTYLWTGLLAISLFLLKKR----ERVQIPVGIIIISGWGIPALLVG 497

Query: 368 LILVMRRVAGDELTGVCYVG--SMDVNALTGFVLIPLA 403
           ++L+  +  GD +    + G   M   A+T F  I +A
Sbjct: 498 VLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIA 535


>gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo
           sapiens]
          Length = 870

 Score = 35.8 bits (81), Expect = 0.11
 Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 6/98 (6%)

Query: 308 GCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTI 367
           G  LVF++LY    ++ LW  +L ++ FL   +    E ++       ++ W IPA+   
Sbjct: 442 GQILVFVLLYSSLYSTYLWTGLLAISLFLLKKR----ERVQIPVGIIIISGWGIPALLVG 497

Query: 368 LILVMRRVAGDELTGVCYVG--SMDVNALTGFVLIPLA 403
           ++L+  +  GD +    + G   M   A+T F  I +A
Sbjct: 498 VLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILIA 535


>gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]
          Length = 995

 Score = 33.9 bits (76), Expect = 0.42
 Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 42/284 (14%)

Query: 188 GRGGCDNPG---KFHHVEKS-ASCAPLCTPGVDVYWSREDKRFAVVWLA--IWAVLCFFS 241
           GRGG  + G   K   + ++  +C+ L + GV +  SR     A +     I  + C  S
Sbjct: 558 GRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLS 617

Query: 242 SAF---TVLTFL-IDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQL 297
           S F   T++T++  +  R  YP + +I L     + ++ +L+             DS   
Sbjct: 618 SIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLL-------------DSWIA 664

Query: 298 YVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLA 357
               +GL    C  V + L+YF + S  W  +     +LA  K + +  I      F + 
Sbjct: 665 LYKMQGL----CISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVF-NTYIRKYILKFCIV 719

Query: 358 AWAIPAVKTILILVMR----------RVAGDELTGVCYVGSMDVNALTGFVLIPLACYL- 406
            W +PAV   +IL +           +         C++ +   NA+    ++   C + 
Sbjct: 720 GWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINN---NAVFYITVVGYFCVIF 776

Query: 407 VIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL 450
           ++  S  +   V L  I++  + G +    ++ L    GL  +L
Sbjct: 777 LLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 820


>gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]
          Length = 1003

 Score = 33.9 bits (76), Expect = 0.42
 Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 42/284 (14%)

Query: 188 GRGGCDNPG---KFHHVEKS-ASCAPLCTPGVDVYWSREDKRFAVVWLA--IWAVLCFFS 241
           GRGG  + G   K   + ++  +C+ L + GV +  SR     A +     I  + C  S
Sbjct: 566 GRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLS 625

Query: 242 SAF---TVLTFL-IDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQL 297
           S F   T++T++  +  R  YP + +I L     + ++ +L+             DS   
Sbjct: 626 SIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLL-------------DSWIA 672

Query: 298 YVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLA 357
               +GL    C  V + L+YF + S  W  +     +LA  K + +  I      F + 
Sbjct: 673 LYKMQGL----CISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVF-NTYIRKYILKFCIV 727

Query: 358 AWAIPAVKTILILVMR----------RVAGDELTGVCYVGSMDVNALTGFVLIPLACYL- 406
            W +PAV   +IL +           +         C++ +   NA+    ++   C + 
Sbjct: 728 GWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINN---NAVFYITVVGYFCVIF 784

Query: 407 VIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL 450
           ++  S  +   V L  I++  + G +    ++ L    GL  +L
Sbjct: 785 LLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 828


>gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]
          Length = 1017

 Score = 33.9 bits (76), Expect = 0.42
 Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 42/284 (14%)

Query: 188 GRGGCDNPG---KFHHVEKS-ASCAPLCTPGVDVYWSREDKRFAVVWLA--IWAVLCFFS 241
           GRGG  + G   K   + ++  +C+ L + GV +  SR     A +     I  + C  S
Sbjct: 580 GRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLS 639

Query: 242 SAF---TVLTFL-IDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQL 297
           S F   T++T++  +  R  YP + +I L     + ++ +L+             DS   
Sbjct: 640 SIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLL-------------DSWIA 686

Query: 298 YVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLA 357
               +GL    C  V + L+YF + S  W  +     +LA  K + +  I      F + 
Sbjct: 687 LYKMQGL----CISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVF-NTYIRKYILKFCIV 741

Query: 358 AWAIPAVKTILILVMR----------RVAGDELTGVCYVGSMDVNALTGFVLIPLACYL- 406
            W +PAV   +IL +           +         C++ +   NA+    ++   C + 
Sbjct: 742 GWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINN---NAVFYITVVGYFCVIF 798

Query: 407 VIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL 450
           ++  S  +   V L  I++  + G +    ++ L    GL  +L
Sbjct: 799 LLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 842


>gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]
          Length = 1014

 Score = 33.9 bits (76), Expect = 0.42
 Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 42/284 (14%)

Query: 188 GRGGCDNPG---KFHHVEKS-ASCAPLCTPGVDVYWSREDKRFAVVWLA--IWAVLCFFS 241
           GRGG  + G   K   + ++  +C+ L + GV +  SR     A +     I  + C  S
Sbjct: 577 GRGGWSDNGCSVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLS 636

Query: 242 SAF---TVLTFL-IDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQL 297
           S F   T++T++  +  R  YP + +I L     + ++ +L+             DS   
Sbjct: 637 SIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLVFLL-------------DSWIA 683

Query: 298 YVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLA 357
               +GL    C  V + L+YF + S  W  +     +LA  K + +  I      F + 
Sbjct: 684 LYKMQGL----CISVAVFLHYFLLVSFTWMGLEAFHMYLALVKVF-NTYIRKYILKFCIV 738

Query: 358 AWAIPAVKTILILVMR----------RVAGDELTGVCYVGSMDVNALTGFVLIPLACYL- 406
            W +PAV   +IL +           +         C++ +   NA+    ++   C + 
Sbjct: 739 GWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCWINN---NAVFYITVVGYFCVIF 795

Query: 407 VIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL 450
           ++  S  +   V L  I++  + G +    ++ L    GL  +L
Sbjct: 796 LLNVSMFIVVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLL 839


>gi|93204873 G protein-coupled receptor 157 [Homo sapiens]
          Length = 335

 Score = 33.9 bits (76), Expect = 0.42
 Identities = 46/202 (22%), Positives = 78/202 (38%), Gaps = 46/202 (22%)

Query: 227 AVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGY---LIRLFA 283
           AVV L+    L    S   V T  + P       R ++FLS+   + +  Y   +++ FA
Sbjct: 16  AVVLLS--CALSALGSGLLVATHALWPDLRSRARRLLLFLSLADLLSAASYFYGVLQNFA 73

Query: 284 GAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWG 343
           G                     S  C L   +  +   +S  W V + L  +L+  +   
Sbjct: 74  GP--------------------SWDCVLQGALSTFANTSSFFWTVAIALYLYLSIVRAAR 113

Query: 344 HEAIEANSSYFHLAAWAIPAVKTILILVMRRV---AGDELTGVCYVGSMDVNA------- 393
               +     FH+ +W +P V T+  + ++++   A D   G C++   D+ A       
Sbjct: 114 GPRTDRLLWAFHVVSWGVPLVITVAAVALKKIGYDASDVSVGWCWI---DLEAKDHVLWM 170

Query: 394 -LTG-------FVLIPLACYLV 407
            LTG       +VL+PL   LV
Sbjct: 171 LLTGKLWEMLAYVLLPLLYLLV 192


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.139    0.458 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,594,820
Number of Sequences: 37866
Number of extensions: 1185302
Number of successful extensions: 3443
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3361
Number of HSP's gapped (non-prelim): 45
length of query: 581
length of database: 18,247,518
effective HSP length: 108
effective length of query: 473
effective length of database: 14,157,990
effective search space: 6696729270
effective search space used: 6696729270
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.