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Search of human proteins with 58219064
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58219064 Src homology 2 domain containing E [Homo sapiens]
(495 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 1003 0.0
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 248 1e-65
gi|106879210 Src homology 2 domain containing adaptor protein B ... 228 7e-60
gi|222537752 Src homology 2 domain containing transforming prote... 201 1e-51
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 57 4e-08
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 57 4e-08
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 57 4e-08
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 57 4e-08
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 57 4e-08
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 56 7e-08
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 54 2e-07
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 54 2e-07
gi|157820785 SH2 domain containing 7 [Homo sapiens] 54 4e-07
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 53 6e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 52 2e-06
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 52 2e-06
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 51 2e-06
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 50 5e-06
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 50 5e-06
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 50 5e-06
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 50 5e-06
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 50 5e-06
gi|18375613 dachshund homolog 1 isoform b [Homo sapiens] 50 6e-06
gi|18375611 dachshund homolog 1 isoform a [Homo sapiens] 50 6e-06
gi|18375609 dachshund homolog 1 isoform c [Homo sapiens] 50 6e-06
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 49 8e-06
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 49 8e-06
gi|224586793 src homology 2 domain-containing transforming prote... 49 1e-05
gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens] 49 1e-05
gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens] 49 1e-05
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 1003 bits (2593), Expect = 0.0
Identities = 495/495 (100%), Positives = 495/495 (100%)
Query: 1 MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKPGG 60
MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKPGG
Sbjct: 1 MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERAKPGG 60
Query: 61 GGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGR 120
GGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGR
Sbjct: 61 GGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGR 120
Query: 121 KNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPS 180
KNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPS
Sbjct: 121 KNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPS 180
Query: 181 SLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITE 240
SLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITE
Sbjct: 181 SLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITE 240
Query: 241 IRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGG 300
IRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGG
Sbjct: 241 IRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGG 300
Query: 301 PRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQH 360
PRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQH
Sbjct: 301 PRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQH 360
Query: 361 HRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVR 420
HRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVR
Sbjct: 361 HRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVR 420
Query: 421 NSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKG 480
NSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKG
Sbjct: 421 NSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKG 480
Query: 481 AEHMTLLYPVHSKLH 495
AEHMTLLYPVHSKLH
Sbjct: 481 AEHMTLLYPVHSKLH 495
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 248 bits (632), Expect = 1e-65
Identities = 158/402 (39%), Positives = 208/402 (51%), Gaps = 108/402 (26%)
Query: 162 PSSSSSSSSSSSSASSSPSSLGPELDKG---------KIIKQQETV-----IILEDYADP 207
P +S + S+S P + GP+ K +II+ ++ + ILEDYADP
Sbjct: 52 PLNSHCAHREPISSSPQPVANGPKQKKKSNWRSTTRLRIIRLRDRLEPRPLAILEDYADP 111
Query: 208 YDAKRT-KGQRDA----ERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCE 262
+D + T +G A E+V ENDGYMEPY+AQ+M+ EIR
Sbjct: 112 FDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIR-------------------- 151
Query: 263 PADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEPAEGG--PRAEGKARPPDSRLPENDER 320
SK+ +P LYDTPYEP E G P EG P +SRLPE+DER
Sbjct: 152 ---------------GSKETATQPLPLYDTPYEPEEDGATPEGEGAPWPRESRLPEDDER 196
Query: 321 PAAEYEQPWEWKKEQIVRALSV-------------------------------------- 342
P EY+QPWEWKKE+I +A +V
Sbjct: 197 PPEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLP 256
Query: 343 ---------QFEGAERPSF---REETVRQHHRQKSWTQKILKPALSDHSE--GEKVDPGL 388
QFEG E+ REE R R + K KP + S GE DP L
Sbjct: 257 EPSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPAL 316
Query: 389 PLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTK 448
PLE Q WYHGAISR +AE+ L+ CKEA YLVRNSE+ + +S++LK+SQG +H+ +++TK
Sbjct: 317 PLENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTK 376
Query: 449 DNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490
++KY L Q S F S+PE+VH+Y++ KLP KGAEHM+LLYPV
Sbjct: 377 EHKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPV 418
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 228 bits (582), Expect = 7e-60
Identities = 161/450 (35%), Positives = 228/450 (50%), Gaps = 77/450 (17%)
Query: 75 GPGPGKGRKNSAAEL----GSGR-AGVGPKDSRLSRDSLQGLIQAAAGKGRK-NSRATEE 128
GPG + + L GSG GV S S G A++G G +S ++
Sbjct: 98 GPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSG 157
Query: 129 EPH--------RGATKSSGCSTYIN---RLIKVDTQEKNGKSNYPSSSSSSSSSSSSASS 177
PH R AT + YI+ RLIKV++ G + + + + S +
Sbjct: 158 SPHLYRSSSERRPATPAE--VRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTAC 215
Query: 178 S--------PSSLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYM 229
+S E GK ++ V I +DY+DP+DAK + + GE+ GYM
Sbjct: 216 GGKKLLNKCAASAAEESGAGK----KDKVTIADDYSDPFDAKNDLKSKAGK--GESAGYM 269
Query: 230 EPYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQL 289
EPY+AQ+++TE +R+ S K +QL
Sbjct: 270 EPYEAQRIMTEFQRQESVRSQHKGIQL--------------------------------- 296
Query: 290 YDTPYEPAEGGPRAEGKA----RPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFE 345
YDTPYEP ++ ++ R +S+LP++D+RPA EY+QPWEW + I AL+ QF
Sbjct: 297 YDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIP-ALAAQFN 355
Query: 346 GAERPSFREETVRQHHRQKSWTQKILKPALSDHSE-----GEKVDPGLPLEKQPWYHGAI 400
G E+ R RQ KP E GE+VDP +PLEKQ WYHGAI
Sbjct: 356 GNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAI 415
Query: 401 SRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAV 460
SR +AE+ L+ CKE YLVRNS++ YS++L+++QG +H+ +A+TK+ KY L Q S
Sbjct: 416 SRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPP 474
Query: 461 FDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490
FDS+PEV+HYY+ KLP KGAEH++LLYPV
Sbjct: 475 FDSVPEVIHYYTTRKLPIKGAEHLSLLYPV 504
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 201 bits (512), Expect = 1e-51
Identities = 116/293 (39%), Positives = 158/293 (53%), Gaps = 67/293 (22%)
Query: 203 DYADPYDAKRTKGQRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCE 262
+Y DP+DA+ D DGYMEPYDAQ +++E
Sbjct: 105 EYLDPFDAQPHPAPPD-------DGYMEPYDAQWVMSE---------------------- 135
Query: 263 PADGGLKSETLAKRRSSKDLLGKPPQLYDTPYEP-----AEGGPRAEGKARPPDSRLPEN 317
L G+ QLYDTPYE A+G P + +P SR+P+
Sbjct: 136 -------------------LPGRGVQLYDTPYEEQDPETADGPPSGQ---KPRQSRMPQE 173
Query: 318 DERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSD 377
DERPA EY+QPWEWKK+ I RA +VQF+ E R +++ +P
Sbjct: 174 DERPADEYDQPWEWKKDHISRAFAVQFDSPE-----------WERTPGSAKELRRPPPRS 222
Query: 378 HSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQ 437
E+VDP LPLEKQPW+HG ++RA+AES L CKE YLVR SE+ S++L++SQ
Sbjct: 223 PQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQ 282
Query: 438 GCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490
G +H+ A+T++N+ L Q S F S+PE+V +YS+ LP +GAEH+ LLYPV
Sbjct: 283 GFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPV 335
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR+ AE L +LVR SES + SI+L+ H
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ T D K + S F ++ E+VH++S
Sbjct: 207 INTTADGKVYVTAESR-FSTLAELVHHHS 234
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR+ AE L +LVR SES + SI+L+ H
Sbjct: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 221
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ T D K + S F ++ E+VH++S
Sbjct: 222 INTTADGKVYVTAESR-FSTLAELVHHHS 249
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR+ AE L +LVR SES + SI+L+ H
Sbjct: 141 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 200
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ T D K + S F ++ E+VH++S
Sbjct: 201 INTTADGKVYVTAESR-FSTLAELVHHHS 228
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR+ AE L +LVR SES + SI+L+ H
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ T D K + S F ++ E+VH++S
Sbjct: 207 INTTADGKVYVTAESR-FSTLAELVHHHS 234
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 57.0 bits (136), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR+ AE L +LVR SES + SI+L+ H
Sbjct: 126 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 185
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ T D K + S F ++ E+VH++S
Sbjct: 186 INTTADGKVYVTAESR-FSTLAELVHHHS 213
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 56.2 bits (134), Expect = 7e-08
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 6/106 (5%)
Query: 389 PLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTK 448
P E +PWY+ ++SR EAE L G + G+ Y+I + H + +
Sbjct: 640 PHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRI--NR 697
Query: 449 DNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHSKL 494
D ++ + TSA F+S+ E+V YY L K M L YPV +L
Sbjct: 698 DGRHFVLGTSAYFESLVELVSYYEKHSLYRK----MRLRYPVTPEL 739
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 54.3 bits (129), Expect = 2e-07
Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR AE L +LVR SES + SI+L+ H
Sbjct: 116 ITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 175
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ D K ++ S F+++ E+VH++S
Sbjct: 176 INTASDGKLYVSSESR-FNTLAELVHHHS 203
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 54.3 bits (129), Expect = 2e-07
Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 384 VDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHII 443
+ P LEK WYHG +SR AE L +LVR SES + SI+L+ H
Sbjct: 135 ITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 194
Query: 444 VAQTKDNKYTLNQTSAVFDSIPEVVHYYS 472
+ D K ++ S F+++ E+VH++S
Sbjct: 195 INTASDGKLYVSSESR-FNTLAELVHHHS 222
>gi|157820785 SH2 domain containing 7 [Homo sapiens]
Length = 451
Score = 53.5 bits (127), Expect = 4e-07
Identities = 25/87 (28%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 394 PWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYT 453
PW+HG I+R + E L+ +L+R S+ Y ++ + S C H ++ Q ++ +Y
Sbjct: 50 PWFHGFITRKQTEQLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYI 108
Query: 454 LNQTSAVFDSIPEVVHYYSNEKL-PFK 479
++ + ++ E+VH+Y +L PFK
Sbjct: 109 ISGDTQSHSTLAELVHHYQEAQLEPFK 135
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 53.1 bits (126), Expect = 6e-07
Identities = 33/102 (32%), Positives = 51/102 (50%), Gaps = 5/102 (4%)
Query: 389 PLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTK 448
PL +Q WYHGAI R EA+ L+ K+ +LVR S Y +++ + H I+ Q
Sbjct: 454 PLAEQDWYHGAIPRIEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFII-QYV 510
Query: 449 DNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPV 490
DN Y T F +IP+++ ++ K + LL P+
Sbjct: 511 DNMYRFEGTG--FSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/99 (36%), Positives = 55/99 (55%), Gaps = 6/99 (6%)
Query: 395 WYHGAISRAEAESRL-QPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYT 453
WY+G ++R +AE L + E +L+R+SES S +S++LK S H V Q DN Y
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKV-QLVDNVYC 343
Query: 454 LNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHS 492
+ Q F ++ E+V +Y +K P +EH LY V +
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLVRA 378
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/99 (36%), Positives = 55/99 (55%), Gaps = 6/99 (6%)
Query: 395 WYHGAISRAEAESRL-QPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYT 453
WY+G ++R +AE L + E +L+R+SES S +S++LK S H V Q DN Y
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKV-QLVDNVYC 343
Query: 454 LNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHS 492
+ Q F ++ E+V +Y +K P +EH LY V +
Sbjct: 344 IGQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLVRA 378
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/89 (32%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 390 LEKQPWYHGAISRAEAESRLQPCKEA--GYLVRNSESGNSRYSIALKTSQGCVHIIVAQT 447
+E +PW+ G ISR+EA RLQ A +L+R SE ++ Y ++++ +Q H + +
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRR 132
Query: 448 KDNKYTLNQTSAVFDSIPEVVHYYSNEKL 476
+ LN+ + F S+PE+V+Y+ + L
Sbjct: 133 AGGRLHLNE-AVSFLSLPELVNYHRAQSL 160
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/104 (30%), Positives = 52/104 (50%), Gaps = 15/104 (14%)
Query: 393 QPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKY 452
QPWY GA+ R +AE+ L + YLVR+ + Y+I++K + HI + T+D +
Sbjct: 110 QPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRDGFF 168
Query: 453 TLNQTSAVFDSIPEVVHYYSNEKL-------------PFKGAEH 483
+ + + F S+ E+V YY + L P+K EH
Sbjct: 169 HIAE-NRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEH 211
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/104 (30%), Positives = 52/104 (50%), Gaps = 15/104 (14%)
Query: 393 QPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKY 452
QPWY GA+ R +AE+ L + YLVR+ + Y+I++K + HI + T+D +
Sbjct: 670 QPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRDGFF 728
Query: 453 TLNQTSAVFDSIPEVVHYYSNEKL-------------PFKGAEH 483
+ + + F S+ E+V YY + L P+K EH
Sbjct: 729 HIAE-NRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEH 771
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 50.1 bits (118), Expect = 5e-06
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 359 QHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYL 418
+HH S + +L E DP L L PW+HG IS EA +LQP ++ +L
Sbjct: 49 KHHT--SGQEGLLAAGALREREALSADPKLSL--MPWFHGKISGQEAVQQLQPPEDGLFL 104
Query: 419 VRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEK 475
VR S Y + + + +H V +D T+++ + F ++ ++V +YS +K
Sbjct: 105 VRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDE-AVFFCNLMDMVEHYSKDK 159
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 50.1 bits (118), Expect = 5e-06
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 359 QHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYL 418
+HH S + +L E DP L L PW+HG IS EA +LQP ++ +L
Sbjct: 91 KHHT--SGQEGLLAAGALREREALSADPKLSL--MPWFHGKISGQEAVQQLQPPEDGLFL 146
Query: 419 VRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEK 475
VR S Y + + + +H V +D T+++ + F ++ ++V +YS +K
Sbjct: 147 VRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDE-AVFFCNLMDMVEHYSKDK 201
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 50.1 bits (118), Expect = 5e-06
Identities = 34/117 (29%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 359 QHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYL 418
+HH S + +L E DP L L PW+HG IS EA +LQP ++ +L
Sbjct: 90 KHHT--SGQEGLLAAGALREREALSADPKLSL--MPWFHGKISGQEAVQQLQPPEDGLFL 145
Query: 419 VRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEK 475
VR S Y + + + +H V +D T+++ + F ++ ++V +YS +K
Sbjct: 146 VRESARHPGDYVLCVSFGRDVIHYRVLH-RDGHLTIDE-AVFFCNLMDMVEHYSKDK 200
>gi|18375613 dachshund homolog 1 isoform b [Homo sapiens]
Length = 558
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/183 (30%), Positives = 71/183 (38%), Gaps = 39/183 (21%)
Query: 4 SPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERA--KPGGG 61
S + +S SS S AP++ A GP + F+ P+ + GGG
Sbjct: 21 STSASSSGTTTSTSSATSSPAPSIGPPASSGPTL----FRPEPIASAAAAAATVTSTGGG 76
Query: 62 GGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGRK 121
GG GG+G G G G G + P + S S G +AG G
Sbjct: 77 GG-------GGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVA 129
Query: 122 NSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSS 181
+S T IN G S+ SSSSSSSSSSSS+SSS SS
Sbjct: 130 SS------------------TPINA--------STGSSSSSSSSSSSSSSSSSSSSSSSS 163
Query: 182 LGP 184
GP
Sbjct: 164 CGP 166
>gi|18375611 dachshund homolog 1 isoform a [Homo sapiens]
Length = 706
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/183 (30%), Positives = 71/183 (38%), Gaps = 39/183 (21%)
Query: 4 SPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERA--KPGGG 61
S + +S SS S AP++ A GP + F+ P+ + GGG
Sbjct: 21 STSASSSGTTTSTSSATSSPAPSIGPPASSGPTL----FRPEPIASAAAAAATVTSTGGG 76
Query: 62 GGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGRK 121
GG GG+G G G G G + P + S S G +AG G
Sbjct: 77 GG-------GGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVA 129
Query: 122 NSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSS 181
+S T IN G S+ SSSSSSSSSSSS+SSS SS
Sbjct: 130 SS------------------TPINA--------STGSSSSSSSSSSSSSSSSSSSSSSSS 163
Query: 182 LGP 184
GP
Sbjct: 164 CGP 166
>gi|18375609 dachshund homolog 1 isoform c [Homo sapiens]
Length = 504
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/183 (30%), Positives = 71/183 (38%), Gaps = 39/183 (21%)
Query: 4 SPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKEFPLNLKTVSERA--KPGGG 61
S + +S SS S AP++ A GP + F+ P+ + GGG
Sbjct: 21 STSASSSGTTTSTSSATSSPAPSIGPPASSGPTL----FRPEPIASAAAAAATVTSTGGG 76
Query: 62 GGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSRLSRDSLQGLIQAAAGKGRK 121
GG GG+G G G G G + P + S S G +AG G
Sbjct: 77 GG-------GGGSGGGGGSSGNGGGGGGGGGGSNCNPNLAAASNGSGGGGGGISAGGGVA 129
Query: 122 NSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSNYPSSSSSSSSSSSSASSSPSS 181
+S T IN G S+ SSSSSSSSSSSS+SSS SS
Sbjct: 130 SS------------------TPINA--------STGSSSSSSSSSSSSSSSSSSSSSSSS 163
Query: 182 LGP 184
GP
Sbjct: 164 CGP 166
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/173 (28%), Positives = 68/173 (39%), Gaps = 28/173 (16%)
Query: 305 GKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQK 364
G PP L ++D + EQ E + + L G RP F
Sbjct: 334 GPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFS----------- 382
Query: 365 SWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSES 424
L P L E +K PL +Q WYHGAI RAE L +LVR S+
Sbjct: 383 ------LPPPLQLIPEVQK-----PLHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQ- 428
Query: 425 GNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLP 477
G Y +++ H I+ Q+ DN Y L F SIP ++ + + + P
Sbjct: 429 GKQEYVLSVLWDGLPRHFII-QSLDNLYRLEGEG--FPSIPLLIDHLLSTQQP 478
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 49.3 bits (116), Expect = 8e-06
Identities = 49/173 (28%), Positives = 68/173 (39%), Gaps = 28/173 (16%)
Query: 305 GKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAERPSFREETVRQHHRQK 364
G PP L ++D + EQ E + + L G RP F
Sbjct: 392 GPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFS----------- 440
Query: 365 SWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSES 424
L P L E +K PL +Q WYHGAI RAE L +LVR S+
Sbjct: 441 ------LPPPLQLIPEVQK-----PLHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQ- 486
Query: 425 GNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLP 477
G Y +++ H I+ Q+ DN Y L F SIP ++ + + + P
Sbjct: 487 GKQEYVLSVLWDGLPRHFII-QSLDNLYRLEGEG--FPSIPLLIDHLLSTQQP 536
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 48.9 bits (115), Expect = 1e-05
Identities = 37/134 (27%), Positives = 60/134 (44%), Gaps = 16/134 (11%)
Query: 371 LKPALSDHSEGEKVDPGLP----------LEKQPWYHGAISRAEAESRLQPCKEAGYLVR 420
L P LS + E + P P L+ + WY G +SR EAE L+ K+ +LVR
Sbjct: 465 LGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLE--KDGDFLVR 522
Query: 421 NSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSIPEVVHYYSNEKLPFKG 480
S + + + + H+++ D + T+ VFDSI +++++ LP
Sbjct: 523 KSTTNPGSFVLTGMHNGQAKHLLLV---DPEGTIRTKDRVFDSISHLINHHLESSLPIVS 579
Query: 481 A-EHMTLLYPVHSK 493
A + L PV K
Sbjct: 580 AGSELCLQQPVERK 593
>gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]
Length = 361
Score = 48.5 bits (114), Expect = 1e-05
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Query: 395 WYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKY-T 453
W+HG I+R EAE L+P + YLVR SES + + + ++ C H ++AQ +D ++
Sbjct: 67 WFHGFITRREAERLLEPKPQGCYLVRFSESAVT-FVLTYRSRTCCRHFLLAQLRDGRHVV 125
Query: 454 LNQTSAVFDSIPEVVHYYSNEKLPF 478
L + SA ++HY ++ P+
Sbjct: 126 LGEDSAHARLQDLLLHYTAHPLSPY 150
>gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]
Length = 371
Score = 48.5 bits (114), Expect = 1e-05
Identities = 28/85 (32%), Positives = 48/85 (56%), Gaps = 2/85 (2%)
Query: 395 WYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKY-T 453
W+HG I+R EAE L+P + YLVR SES + + + ++ C H ++AQ +D ++
Sbjct: 77 WFHGFITRREAERLLEPKPQGCYLVRFSESAVT-FVLTYRSRTCCRHFLLAQLRDGRHVV 135
Query: 454 LNQTSAVFDSIPEVVHYYSNEKLPF 478
L + SA ++HY ++ P+
Sbjct: 136 LGEDSAHARLQDLLLHYTAHPLSPY 160
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,120,256
Number of Sequences: 37866
Number of extensions: 1176033
Number of successful extensions: 11585
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 222
Number of HSP's successfully gapped in prelim test: 382
Number of HSP's that attempted gapping in prelim test: 8103
Number of HSP's gapped (non-prelim): 2236
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.