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Search of human proteins with 58218970
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58218970 protease, serine, 36 [Homo sapiens]
(855 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58218970 protease, serine, 36 [Homo sapiens] 1819 0.0
gi|87196600 polyserase 3 [Homo sapiens] 318 1e-86
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 241 2e-63
gi|117956391 protease, serine, 33 [Homo sapiens] 230 5e-60
gi|4506153 prostasin preproprotein [Homo sapiens] 224 3e-58
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 218 2e-56
gi|13994276 marapsin [Homo sapiens] 216 7e-56
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 215 2e-55
gi|11415040 matriptase [Homo sapiens] 210 5e-54
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 204 2e-52
gi|11545839 protease, serine, 22 [Homo sapiens] 204 3e-52
gi|205360905 testis-specific serine protease 1 [Homo sapiens] 202 1e-51
gi|5803197 testisin isoform 1 [Homo sapiens] 202 1e-51
gi|21614531 testisin isoform 2 [Homo sapiens] 198 2e-50
gi|223942069 enterokinase precursor [Homo sapiens] 191 2e-48
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 189 1e-47
gi|33695155 hepsin [Homo sapiens] 187 4e-47
gi|4504481 hepsin [Homo sapiens] 187 4e-47
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 187 4e-47
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 185 1e-46
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] 185 2e-46
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 183 5e-46
gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens] 182 9e-46
gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo ... 182 9e-46
gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo ... 182 9e-46
gi|68508970 tryptase beta 2 precursor [Homo sapiens] 182 1e-45
gi|29244926 corin [Homo sapiens] 181 3e-45
gi|148806900 epidermis-specific serine protease-like protein [Ho... 180 6e-45
gi|21614533 testisin isoform 3 [Homo sapiens] 178 2e-44
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 174 3e-43
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 1819 bits (4711), Expect = 0.0
Identities = 855/855 (100%), Positives = 855/855 (100%)
Query: 1 MARHLLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPW 60
MARHLLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPW
Sbjct: 1 MARHLLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPW 60
Query: 61 QVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTR 120
QVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTR
Sbjct: 61 QVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTR 120
Query: 121 AVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGD 180
AVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGD
Sbjct: 121 AVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGD 180
Query: 181 VQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQ 240
VQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQ
Sbjct: 181 VQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQ 240
Query: 241 GDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFP 300
GDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFP
Sbjct: 241 GDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFP 300
Query: 301 TQPQKTQSDPQEPREENCTIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLA 360
TQPQKTQSDPQEPREENCTIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLA
Sbjct: 301 TQPQKTQSDPQEPREENCTIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLA 360
Query: 361 PASCFLDPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNASDLALLQLRTPV 420
PASCFLDPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNASDLALLQLRTPV
Sbjct: 361 PASCFLDPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNASDLALLQLRTPV 420
Query: 421 NLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQG 480
NLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQG
Sbjct: 421 NLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQG 480
Query: 481 AAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPRAF 540
AAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPRAF
Sbjct: 481 AAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPRAF 540
Query: 541 FPLQTHGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEAAPVGVL 600
FPLQTHGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEAAPVGVL
Sbjct: 541 FPLQTHGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEAAPVGVL 600
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
Query: 661 VSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAGIPPGASCWVLGWKEPQ 720
VSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAGIPPGASCWVLGWKEPQ
Sbjct: 661 VSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAGIPPGASCWVLGWKEPQ 720
Query: 721 DRVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWI 780
DRVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWI
Sbjct: 721 DRVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWI 780
Query: 781 LVGMAVQGSRELFAAIGPEEAWISQTVGEANFLPPSGSPHWPTGGSNLCPPELAKASGSP 840
LVGMAVQGSRELFAAIGPEEAWISQTVGEANFLPPSGSPHWPTGGSNLCPPELAKASGSP
Sbjct: 781 LVGMAVQGSRELFAAIGPEEAWISQTVGEANFLPPSGSPHWPTGGSNLCPPELAKASGSP 840
Query: 841 HAVYFLLLLTLLIQS 855
HAVYFLLLLTLLIQS
Sbjct: 841 HAVYFLLLLTLLIQS 855
>gi|87196600 polyserase 3 [Homo sapiens]
Length = 553
Score = 318 bits (816), Expect = 1e-86
Identities = 199/537 (37%), Positives = 275/537 (51%), Gaps = 43/537 (8%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CG+ P N PG WPWQ S+ G HIC GSL+A +WVL+AAHCF E
Sbjct: 28 CGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATE- 86
Query: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWP 157
WSV+LG ++G GA VAA+ +P Y+ G+DLALL+LA P + P
Sbjct: 87 LNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTT----HTP 142
Query: 158 VCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFN 217
+CLP+ +HRF G +CWATGW + D P L+ + LRL+ TC C+Y+Q +
Sbjct: 143 LCLPQPAHRFPFGASCWATGW----DQDTSDAPGTLRNLRLRLISRPTCNCIYNQLHQRH 198
Query: 218 LTLQILPGMLCAGYPEGRRDTCQGDSGGPLVC-EEGGRWFQAGITSFGFGCGRRNRPGVF 276
L+ PGMLC G G + CQGDSGGP++C E G W QAGI SF C + + P +
Sbjct: 199 LSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLL 258
Query: 277 TAVATYEAWIREQVMGSEPGPAFPTQPQKTQSDPQEPREENCTI--ALPECG-KAPRPGA 333
T A + +W++ +V G+ AF Q +T P+ E++C +L G +A P
Sbjct: 259 TNTAAHSSWLQARVQGA----AFLAQSPET---PEMSDEDSCVACGSLRTAGPQAGAPSP 311
Query: 334 WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLPSRPRAER 393
WPWEA++M G C GALVSE VL A CF+ + + W V L +RP
Sbjct: 312 WPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEE-------WSVGLGTRPEEWG 364
Query: 394 VARLVQHENASW-DNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWGRG 452
+ +L+ H + + D+ALL L PV L A+ RP+CLP+P+H+ G R + GR
Sbjct: 365 LKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVL--GRA 422
Query: 453 EPALGPGAL--LEAELLGGWWCHCLYGRQGAAVPLPGDP--PHALCPAYQEKEEVGSCWN 508
P G +L + LLG C L+ G G P P +C + E+ SC
Sbjct: 423 RPGAGISSLQTVPVTLLGPRACSRLHAAPGG----DGSPILPGMVCTS--AVGELPSCEG 476
Query: 509 DSRWSLLCQEEGTWFLAGIRDFPSGC---LRPRAFFPLQTHGPWISHVTRGAYLEDQ 562
S L+ + GTWFLAG+ F C RP F L + W+S + Y ++
Sbjct: 477 LSGAPLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEE 533
Score = 154 bits (388), Expect = 4e-37
Identities = 100/262 (38%), Positives = 126/262 (48%), Gaps = 19/262 (7%)
Query: 25 ALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLS 84
A SP E D D S R G P WPW+ L H G CGG+L++ VL+
Sbjct: 279 AQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLT 338
Query: 85 AAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLR 144
AAHCF+ E EWSV LG ++ L +++ Y+ E G D+ALL
Sbjct: 339 AAHCFIGRQAPE---EWSVGLGTRPEEWGL--------KQLILHGAYTHPEGGYDMALLL 387
Query: 145 LASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEA 204
LA P +LG ++ P+CLP H G W G A P LQ V + LLG
Sbjct: 388 LAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG-----RARPGAGISSLQTVPVTLLGPR 442
Query: 205 TCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFG 264
C L++ PG ILPGM+C G +C+G SG PLV E G WF AG+ SFG
Sbjct: 443 ACSRLHAAPGGDG--SPILPGMVCTS-AVGELPSCEGLSGAPLVHEVRGTWFLAGLHSFG 499
Query: 265 FGCGRRNRPGVFTAVATYEAWI 286
C RP VFTA+ YE W+
Sbjct: 500 DACQGPARPAVFTALPAYEDWV 521
Score = 150 bits (378), Expect = 6e-36
Identities = 155/530 (29%), Positives = 216/530 (40%), Gaps = 77/530 (14%)
Query: 310 PQEPREENCTIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPN 369
P +P+E N PG WPW+A V G+ C G+LV+++WVL A CF
Sbjct: 35 PPKPQEGNTV-----------PGEWPWQASVRRQGAHICSGSLVADTWVLTAAHCF---- 79
Query: 370 SSDSPPRDLDAWRVLLPS------RPRAERV---ARLVQHENASWDNASDLALLQLRTPV 420
+ +L++W V+L S P AE V A + + SDLALLQL P
Sbjct: 80 -EKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPT 138
Query: 421 NLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPALGPGAL--LEAELLGGWWCHCLYGR 478
+ P+CLP P H F G+ C W + + + PG L L L+ C+C+Y +
Sbjct: 139 THT----PLCLPQPAHRFPFGASCWATGWDQ-DTSDAPGTLRNLRLRLISRPTCNCIYNQ 193
Query: 479 QGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGCLR- 536
P LC Q + G C DS +LC E +G W AGI F S C +
Sbjct: 194 LHQRHLSNPARPGMLCGGPQPGVQ-GPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQE 252
Query: 537 --PRAFFPLQTHGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEA 594
P H W+ +GA Q ET ACG A
Sbjct: 253 DAPVLLTNTAAHSSWLQARVQGAAFLAQ----------SPETPEMSDEDSCVACGSLRTA 302
Query: 595 APVGVL---WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAG 651
P WPW A + G C G L++ VL A HC + G V LG
Sbjct: 303 GPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFI--GRQAPEEWSVGLG--- 357
Query: 652 ASSLPQGHQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICL-HP-AGIPPGA 709
+ P+ + +L++ G +ALL L+ V S P+CL +P +P G
Sbjct: 358 --TRPEEWGLKQLILHGAYTHPEG-GYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGE 414
Query: 710 SCWVLGWKEPQDRVP--VAAAVSILTQRICDCLYQ------GILPPGTLCVLYAEGQENR 761
WVLG P + V++L R C L+ + PG +C A G+
Sbjct: 415 RGWVLGRARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCT-SAVGELPS 473
Query: 762 CEMTSAPPLLCQMTEGSWILVGM-----AVQGSRE--LFAAIGPEEAWIS 804
CE S PL+ ++ G+W L G+ A QG +F A+ E W+S
Sbjct: 474 CEGLSGAPLVHEV-RGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVS 522
Score = 98.6 bits (244), Expect = 2e-20
Identities = 79/293 (26%), Positives = 117/293 (39%), Gaps = 51/293 (17%)
Query: 563 LAWDWGP-----------DGEETETQTC------PPHTEHGACGLRLEAAPVGVLWPWLA 605
+ W WGP +G + + C PP + G V WPW A
Sbjct: 1 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNT--------VPGEWPWQA 52
Query: 606 EVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSL-PQGHQVSRL 664
V G +C+G L+A WVL A HC + +T + V LG L P +V
Sbjct: 53 SVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVG-- 110
Query: 665 VISIRLPQ---HLGLRPPLALLELSSRVEPSPSALPICLHPAGIPPGASCWVLGWKEPQD 721
V +++LP+ H LALL+L+ +P LP H P GASCW GW +
Sbjct: 111 VAALQLPRAYNHYSQGSDLALLQLAHPTTHTPLCLPQPAH--RFPFGASCWATGWDQDTS 168
Query: 722 RVPVA---AAVSILTQRICDCLYQGI--------LPPGTLCVLYAEGQENRCEMTSAPPL 770
P + ++++ C+C+Y + PG LC G + C+ S P+
Sbjct: 169 DAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPV 228
Query: 771 LCQMTEGSWILVGM-------AVQGSRELFAAIGPEEAWISQTVGEANFLPPS 816
LC +G W+ G+ A + + L +W+ V A FL S
Sbjct: 229 LCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQS 281
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 241 bits (616), Expect = 2e-63
Identities = 187/576 (32%), Positives = 262/576 (45%), Gaps = 96/576 (16%)
Query: 33 PEDLDCG-RP--EPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCF 89
P+ +CG RP E R+VGG A G PWQVSL G H CG +++ W+LSAAHCF
Sbjct: 487 PKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCF 546
Query: 90 MTNGTLEPAAEWSVLLGVHSQDGPLDGAHTR-AVAAIVVPANYSQVELGADLALLRLASP 148
+ A LG S G L G+ + + +V+ Y+ L DLA+L LASP
Sbjct: 547 NHTKVEQVRAH----LGTASLLG-LGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASP 601
Query: 149 ASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQC 208
+ + PVCLP A +F G C +GWG+ QE + P +LQ+ + ++ + TC
Sbjct: 602 LAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATK-PELLQKASVGIIDQKTCSV 660
Query: 209 LYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEG-GRWFQAGITSFGFGC 267
LY+ F+LT M+CAG+ EG+ D+CQGDSGGPL CEE G ++ AGI S+G GC
Sbjct: 661 LYN----FSLT----DRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGC 712
Query: 268 GRRNRPGVFTAVATYEAWIREQVMGSEPGPAFP---------TQPQKTQ------SDPQE 312
+ +PGV+T + + WI E +M S+P P P T P+ T + P
Sbjct: 713 AQVKKPGVYTRITRLKGWILE-IMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSR 771
Query: 313 P----------REENCTIA-----------------------LPECGKAPRP-------- 331
P + N T++ LP+CG AP
Sbjct: 772 PTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGS 831
Query: 332 ----GAWPWEAQVMV-PGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLP 386
G WPW+ + + C LV+E W+L+ A CF D L
Sbjct: 832 AAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCF-DVYGDPKQWAAFLGTPFLSG 890
Query: 387 SRPRAERVARLVQHENAS-WDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCR 445
+ + ERVAR+ +H + + D+ALL+L PV S RP+CLP P G+RC
Sbjct: 891 AEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCV 950
Query: 446 LARWGRGEPALGPGALLE---AELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEE 502
+ WG L+ LL C Y Q ++ LC + +
Sbjct: 951 ITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISS--------RMLCAGFPQ-GG 1001
Query: 503 VGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGCLRP 537
V SC D+ L C+E G W L G+ + GC RP
Sbjct: 1002 VDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRP 1037
Score = 231 bits (590), Expect = 2e-60
Identities = 170/534 (31%), Positives = 234/534 (43%), Gaps = 64/534 (11%)
Query: 44 SARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSV 103
+ RIVGG A PG +PWQ SL H CG ++I W++SAAHCF + +W
Sbjct: 200 AGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCF---NEFQDPTKWVA 256
Query: 104 LLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRA 163
+G G V IV Y+ D+A+L L SP G + PVCLP A
Sbjct: 257 YVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAA 316
Query: 164 SHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQIL 223
+H F C +GWG ++E D L P VLQ+ + LL +A C LY +
Sbjct: 317 THIFPPSKKCLISGWGYLKE-DFLVKPEVLQKATVELLDQALCASLYGH--------SLT 367
Query: 224 PGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGCGRRNRPGVFTAVATY 282
M+CAGY +G+ D+CQGDSGGPLVCEE GR+F AGI S+G GC RPGV+ V
Sbjct: 368 DRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRL 427
Query: 283 EAWIREQVMGSE-------------PGPAFPTQPQK-TQSDPQEPREENCTI-------- 320
WI E + P A+PT P+ S P + + T+
Sbjct: 428 RDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVP 487
Query: 321 ALPECGKAP--------------RPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFL 366
L ECG P G PW+ + C +V + W+L+ A CF
Sbjct: 488 KLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFN 547
Query: 367 DPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNAS-DLALLQLRTPVNLSAA 425
A + L P + R+V H + DLA+L+L +P+ +
Sbjct: 548 HTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKY 607
Query: 426 SRPVCLPHPEHYFLPGSRCRLARWGRGEP--ALGPGALLEAE--LLGGWWCHCLYGRQGA 481
+PVCLP F G +C ++ WG + A P L +A ++ C LY
Sbjct: 608 IQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLT 667
Query: 482 AVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGC 534
+C + E +V SC DS L C+E G ++LAGI + GC
Sbjct: 668 --------DRMICAGFLE-GKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGC 712
Score = 189 bits (480), Expect = 9e-48
Identities = 113/257 (43%), Positives = 140/257 (54%), Gaps = 18/257 (7%)
Query: 37 DCG-RPEPSARIVGGSNAQPGTWPWQVSLH-HGGGHICGGSLIAPSWVLSAAHCFMTNGT 94
DCG P RIVGGS A G WPWQVSL H CG L+A W+LSAAHCF G
Sbjct: 816 DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875
Query: 95 LEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPA 154
+ +W+ LG G +G R VA I Y+ L D+ALL LA P
Sbjct: 876 PK---QWAAFLGTPFLSGA-EGQLER-VARIYKHPFYNLYTLDYDVALLELAGPVRRSRL 930
Query: 155 VWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPG 214
V P+CLP + R GT C TGWG V+E + LQ+ +RLL E TC+ Y
Sbjct: 931 VRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQ--LQKAAVRLLSEQTCRRFYP--- 985
Query: 215 PFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGCGRRNRP 273
+QI MLCAG+P+G D+C GD+GGPL C E GRW G+TS+G+GCGR + P
Sbjct: 986 -----VQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFP 1040
Query: 274 GVFTAVATYEAWIREQV 290
GV+T VA WI + +
Sbjct: 1041 GVYTRVAAVRGWIGQHI 1057
Score = 138 bits (347), Expect = 2e-32
Identities = 142/553 (25%), Positives = 216/553 (39%), Gaps = 87/553 (15%)
Query: 307 QSDPQEPREENCTIALPECGKAPR--------------PGAWPWEAQVMVPGSRPCHGAL 352
+ D QE + A ECG P PG +PW+A + C A+
Sbjct: 173 ECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAI 232
Query: 353 VSESWVLAPASCFLDPNSSDSPPRDLDAWRVLLPSRPRAE----RVARLVQHENASWDNA 408
++ W+++ A CF N P + + S A +V ++V+H + D A
Sbjct: 233 INARWLVSAAHCF---NEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTA 289
Query: 409 S-DLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWG--RGEPALGPGALLEA- 464
D+A+L+L +P+ +PVCLP H F P +C ++ WG + + + P L +A
Sbjct: 290 DFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKAT 349
Query: 465 -ELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQE-EGTW 522
ELL C LYG +C Y + + V SC DS L+C+E G +
Sbjct: 350 VELLDQALCASLYGHSLT--------DRMVCAGYLDGK-VDSCQGDSGGPLVCEEPSGRF 400
Query: 523 FLAGIRDFPSGCL---RPRAFFPLQTHGPWISHVTRGAYL-----------EDQLAWDWG 568
FLAGI + GC RP + + WI T A + AW
Sbjct: 401 FLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTS 460
Query: 569 PDGEETETQTCPPHT------------EHGACGLR-LEAAPVGVLW---------PWLAE 606
P+ T T + CG R P V+ PW
Sbjct: 461 PESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVS 520
Query: 607 VHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRA---GASSLPQGHQVSR 663
+ C ++ W+L+A HC T V + +LG A G P + R
Sbjct: 521 LKEGSRHFCGATVVGDRWLLSAAHCF---NHTKVEQVRAHLGTASLLGLGGSPVKIGLRR 577
Query: 664 LVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGWKEPQD 721
+V+ + L LA+LEL+S + + P+CL A P G C + GW Q+
Sbjct: 578 VVLHPLYNPGI-LDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQE 636
Query: 722 ------RVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMT 775
+ A+V I+ Q+ C LY L +C + EG+ + C+ S PL C+
Sbjct: 637 GNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEA 696
Query: 776 EGSWILVGMAVQG 788
G + L G+ G
Sbjct: 697 PGVFYLAGIVSWG 709
Score = 72.8 bits (177), Expect = 1e-12
Identities = 72/267 (26%), Positives = 109/267 (40%), Gaps = 36/267 (13%)
Query: 569 PDGEETETQTCPPHTEHGACGLRLEAAPVGVL---------WPWLAEVHVAG-DRVCTGI 618
PD E T HT+ CGL AA ++ WPW + + + C +
Sbjct: 803 PDAPEATT-----HTQLPDCGLA-PAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAV 856
Query: 619 LLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQH--LGL 676
L+A W+L+A HC G +LG S Q+ R+ + P + L
Sbjct: 857 LVAERWLLSAAHCFDVYGDPK--QWAAFLGTPFLSGAEG--QLERVARIYKHPFYNLYTL 912
Query: 677 RPPLALLELSSRVEPSPSALPICL-HPAGIPP-GASCWVLGWKEPQDRVPVA-----AAV 729
+ALLEL+ V S PICL PA PP G C + GW ++ +A AAV
Sbjct: 913 DYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAV 972
Query: 730 SILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG- 788
+L+++ C Y + LC + +G + C + PL C+ G W+L G+ G
Sbjct: 973 RLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGY 1032
Query: 789 ------SRELFAAIGPEEAWISQTVGE 809
++ + WI Q + E
Sbjct: 1033 GCGRPHFPGVYTRVAAVRGWIGQHIQE 1059
Score = 70.5 bits (171), Expect = 6e-12
Identities = 71/295 (24%), Positives = 123/295 (41%), Gaps = 47/295 (15%)
Query: 569 PDGEETETQTCPPHTEHGACGLR------------LEAAPVGVLWPWLAEVHVAGDRVCT 616
P+ ++ E + H CGL+ +EA+P +PW A + + C
Sbjct: 172 PECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGGMEASPGE--FPWQASLRENKEHFCG 229
Query: 617 GILLAPGWVLAATHCV--LRPGSTTVPYI-EVYLGRAGASSLPQGHQVSRLVISIRLPQH 673
++ W+++A HC + + V Y+ YL + AS++ +++V ++ P +
Sbjct: 230 AAIINARWLVSAAHCFNEFQDPTKWVAYVGATYLSGSEASTVR-----AQVVQIVKHPLY 284
Query: 674 LGLRP--PLALLELSSRVEPSPSALPICLHPAG--IPPGASCWVLGW---KEP---QDRV 723
+A+LEL+S + P+CL A PP C + GW KE + V
Sbjct: 285 NADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEV 344
Query: 724 PVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVG 783
A V +L Q +C LY L +C Y +G+ + C+ S PL+C+ G + L G
Sbjct: 345 LQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAG 404
Query: 784 MAVQG-------SRELFAAIGPEEAWISQTVGEANF--------LPPSGSPHWPT 823
+ G ++A + WI + +A+ P + S WPT
Sbjct: 405 IVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPT 459
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 230 bits (586), Expect = 5e-60
Identities = 119/254 (46%), Positives = 147/254 (57%), Gaps = 4/254 (1%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CG+P S+RIVGG + + G WPWQ S+ H G H+CGGSLIAP WVL+AAHCF
Sbjct: 28 CGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRAL--- 84
Query: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWP 157
AE+ V LG + V +++P +YS+ DLALL+L P L V P
Sbjct: 85 PAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQP 144
Query: 158 VCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFN 217
VCLP R GT C TGWG ++ PLP LQ V + LL TC LY
Sbjct: 145 VCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVP 204
Query: 218 LTLQI-LPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVF 276
+I LPG LCAGYP+G +D CQGDSGGPL C + G W G+ S+G GC NRPGV+
Sbjct: 205 QAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVY 264
Query: 277 TAVATYEAWIREQV 290
T+VATY WI+ +V
Sbjct: 265 TSVATYSPWIQARV 278
Score = 117 bits (293), Expect = 5e-26
Identities = 89/249 (35%), Positives = 118/249 (47%), Gaps = 38/249 (15%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDA-WRVL 384
G+ R G WPW+A + G+ C G+L++ WVL A CF P R L A +RV
Sbjct: 40 GRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCF--------PRRALPAEYRVR 91
Query: 385 LPS--------RPRAERVARLVQHENASWDNA-SDLALLQLRTPVNLSAASRPVCLPHPE 435
L + R + V R++ + S D A DLALLQLR PV LSA +PVCLP P
Sbjct: 92 LGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPG 151
Query: 436 HYFLPGSRCRLARWGRGEPAL-----GPGALLEAELLGGWWCHCLYGRQGAAVP------ 484
PG+ CR+ WG P + P + LL C LY GA VP
Sbjct: 152 ARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLY-HVGADVPQAERIV 210
Query: 485 LPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFF 541
LPG +LC Y + + +C DS L C + G+W L G+ + GC RP +
Sbjct: 211 LPG----SLCAGYPQGHK-DACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYT 265
Query: 542 PLQTHGPWI 550
+ T+ PWI
Sbjct: 266 SVATYSPWI 274
Score = 105 bits (261), Expect = 2e-22
Identities = 73/209 (34%), Positives = 96/209 (45%), Gaps = 25/209 (11%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW A + G VC G L+AP WVL A HC R + + R G++S
Sbjct: 48 WPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTS---PRT 104
Query: 661 VSRLVISIRLPQHL---GLRPPLALLELSSRVEPSPSALPICLHPAGI--PPGASCWVLG 715
+S V + LP G R LALL+L V S P+CL G PPG C V G
Sbjct: 105 LSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTG 164
Query: 716 WKEPQDRVPV-------AAAVSILTQRICDCLY---------QGILPPGTLCVLYAEGQE 759
W + VP+ V +L R CD LY + I+ PG+LC Y +G +
Sbjct: 165 WGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHK 224
Query: 760 NRCEMTSAPPLLCQMTEGSWILVGMAVQG 788
+ C+ S PL C + GSW+LVG+ G
Sbjct: 225 DACQGDSGGPLTC-LQSGSWVLVGVVSWG 252
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 224 bits (570), Expect = 3e-58
Identities = 119/283 (42%), Positives = 160/283 (56%), Gaps = 6/283 (2%)
Query: 27 SPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAA 86
S T E + CG P ARI GGS+A G WPWQVS+ + G H+CGGSL++ WVLSAA
Sbjct: 26 SGTGAEGAEAPCG-VAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAA 84
Query: 87 HCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLA 146
HCF + E + V LG H D + A + I+ +Y Q D+ALL+L+
Sbjct: 85 HCFPSEHHKEA---YEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLS 141
Query: 147 SPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATC 206
P + + P+CLP A+ F +G C TGWG V + L P LQ++E+ L+ TC
Sbjct: 142 RPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETC 201
Query: 207 QCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFG 266
CLY+ + M+CAGY EG +D CQGDSGGPL C G W+ GI S+G
Sbjct: 202 NCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDA 261
Query: 267 CGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFPTQPQKTQSD 309
CG RNRPGV+T ++Y +WI+ +V +E P Q Q++Q D
Sbjct: 262 CGARNRPGVYTLASSYASWIQSKV--TELQPRVVPQTQESQPD 302
Score = 107 bits (266), Expect = 6e-23
Identities = 88/319 (27%), Positives = 135/319 (42%), Gaps = 50/319 (15%)
Query: 325 CGKAPRP----------GAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSP 374
CG AP+ G WPW+ + G C G+LVSE WVL+ A CF + ++
Sbjct: 37 CGVAPQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAY 96
Query: 375 PRDLDAWRVLLPSR-PRAERVARLVQHENASWDNA-SDLALLQLRTPVNLSAASRPVCLP 432
L A ++ S + + ++ H + + + D+ALLQL P+ S RP+CLP
Sbjct: 97 EVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLP 156
Query: 433 HPEHYFLPGSRCRLARWGRGEPALG-----PGALLEAELLGGWWCHCLYGRQGAAVPLPG 487
F G C + WG P++ P LE L+ C+CLY +
Sbjct: 157 AANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYN-----IDAKP 211
Query: 488 DPPH-----ALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC---LRPRA 539
+ PH +C Y E + +C DS L C EG W+L GI + C RP
Sbjct: 212 EEPHFVQEDMVCAGYVEGGK-DACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGV 270
Query: 540 FFPLQTHGPWI-SHVTRGAYLEDQLAWDWGPDGEET--ETQTCPPHTEHGACGLRLEAAP 596
+ ++ WI S VT L+ ++ P +E+ ++ C H + + P
Sbjct: 271 YTLASSYASWIQSKVTE---LQPRVV----PQTQESQPDSNLCGSHLAFSSAPAQGLLRP 323
Query: 597 V---------GVLWPWLAE 606
+ G+L PWL+E
Sbjct: 324 ILFLPLGLALGLLSPWLSE 342
Score = 90.5 bits (223), Expect = 6e-18
Identities = 80/265 (30%), Positives = 107/265 (40%), Gaps = 34/265 (12%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW + G VC G L++ WVL+A HC P EV LG S + +
Sbjct: 56 WPWQVSITYEGVHVCGGSLVSEQWVLSAAHCF--PSEHHKEAYEVKLGAHQLDSYSEDAK 113
Query: 661 VSRLVISIRLPQHL--GLRPPLALLELSSRVEPSPSALPICLHP--AGIPPGASCWVLGW 716
VS L I P +L G + +ALL+LS + S PICL A P G C V GW
Sbjct: 114 VSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGW 173
Query: 717 KEPQDRVPVAA-------AVSILTQRICDCLYQGILPP--------GTLCVLYAEGQENR 761
V + V ++++ C+CLY P +C Y EG ++
Sbjct: 174 GHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDA 233
Query: 762 CEMTSAPPLLCQMTEGSWILVGMAVQGSR-------ELFAAIGPEEAWISQTVGEANFLP 814
C+ S PL C + EG W L G+ G ++ +WI V E L
Sbjct: 234 CQGDSGGPLSCPV-EGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTE---LQ 289
Query: 815 PSGSPHWPTG--GSNLCPPELAKAS 837
P P SNLC LA +S
Sbjct: 290 PRVVPQTQESQPDSNLCGSHLAFSS 314
>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
Length = 321
Score = 218 bits (554), Expect = 2e-56
Identities = 127/272 (46%), Positives = 161/272 (59%), Gaps = 23/272 (8%)
Query: 38 CGRPEPS---ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGT 94
CGRP+ S RIVGG A G WPWQ SL H+CGGSL++P WVL+AAHCF +G+
Sbjct: 26 CGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCF--SGS 83
Query: 95 LEPAAEWSVLLG-VHSQDGPLDGAHTRAVAAIVVPANYS-QVELGADLALLRLASPASLG 152
L ++++ V LG + P H V I++ ++ S Q D+AL+ L+ P +L
Sbjct: 84 LN-SSDYQVHLGELEITLSP----HFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLS 138
Query: 153 PAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQ 212
+ PVCLP AS F G CW TGWG +E +PLP P+ L+EV++ ++ TC+ Y
Sbjct: 139 SRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDY-- 196
Query: 213 PGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNR 272
PGP LQ P MLCA G D CQ DSGGPLVC+ G W QAGI S+G GCGR NR
Sbjct: 197 PGPGGSILQ--PDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNR 251
Query: 273 PGVFTAVATYEAWIREQVM---GSEPG-PAFP 300
PGV+T V Y WIR + GSE G P P
Sbjct: 252 PGVYTRVPAYVNWIRRHITASGGSESGYPRLP 283
Score = 104 bits (260), Expect = 3e-22
Identities = 72/219 (32%), Positives = 100/219 (45%), Gaps = 17/219 (7%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G A GAWPW+A + + C G+L+S WVL A CF +S L + L
Sbjct: 41 GHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITL 100
Query: 386 PSRPRAERVARLVQHENASWD--NASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSR 443
P V +++ H + S + D+AL++L PV LS+ PVCLP F PG R
Sbjct: 101 S--PHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIR 158
Query: 444 CRLARWG---RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQ 498
C + WG GEP P +L E + ++ C Y G ++ P LC
Sbjct: 159 CWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSIL----QPDMLC---- 210
Query: 499 EKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRP 537
+ +C +DS L+CQ G W AGI + GC RP
Sbjct: 211 ARGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRP 249
Score = 99.4 bits (246), Expect = 1e-20
Identities = 70/208 (33%), Positives = 95/208 (45%), Gaps = 20/208 (9%)
Query: 594 AAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGAS 653
AAP G WPW A + + VC G LL+P WVL A HC GS +V+LG +
Sbjct: 43 AAPAGA-WPWQASLRLRRVHVCGGSLLSPQWVLTAAHCF--SGSLNSSDYQVHLGELEIT 99
Query: 654 SLPQGHQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGASC 711
P V ++++ G +AL+ELS V S LP+CL A PG C
Sbjct: 100 LSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRC 159
Query: 712 WVLGWKEPQDRVPV-------AAAVSILTQRICDCLYQG----ILPPGTLCVLYAEGQEN 760
WV GW ++ P+ VS++ C Y G IL P LC A G +
Sbjct: 160 WVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLC---ARGPGD 216
Query: 761 RCEMTSAPPLLCQMTEGSWILVGMAVQG 788
C+ S PL+CQ+ G+W+ G+ G
Sbjct: 217 ACQDDSGGPLVCQV-NGAWVQAGIVSWG 243
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 216 bits (550), Expect = 7e-56
Identities = 113/264 (42%), Positives = 144/264 (54%), Gaps = 8/264 (3%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CGRP R+VGG + Q G WPWQVS+ G H CGGSLIA WVL+AAHCF
Sbjct: 26 CGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSE--- 82
Query: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPAN--YSQVELGADLALLRLASPASLGPAV 155
+ + VLLG P G H V +N Y AD+AL+ L +P +
Sbjct: 83 TSLYQVLLGARQLVQP--GPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYI 140
Query: 156 WPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGP 215
PVCLP S F G CW TGWG E D LP P +LQ++ + ++ C LYS+
Sbjct: 141 LPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTE 200
Query: 216 FNLTLQILPG-MLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPG 274
F + + MLCAG+ EG++D C+GDSGGPLVC G W QAG+ S+G GC R+NRPG
Sbjct: 201 FGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPG 260
Query: 275 VFTAVATYEAWIREQVMGSEPGPA 298
V+ V + WI + + PA
Sbjct: 261 VYIRVTAHHNWIHRIIPKLQFQPA 284
Score = 90.9 bits (224), Expect = 5e-18
Identities = 76/267 (28%), Positives = 115/267 (43%), Gaps = 18/267 (6%)
Query: 299 FPTQPQKTQSDPQEPREENCTIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWV 358
F +Q K + PR N + G+ + G WPW+ + GS C G+L++E WV
Sbjct: 15 FGSQRAKAATACGRPRMLNRMVG----GQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWV 70
Query: 359 LAPASCFLDPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHEN----ASWDNASDLALL 414
L A CF + S S + L R L+ P A AR+ Q E+ +++D+AL+
Sbjct: 71 LTAAHCFRN-TSETSLYQVLLGARQLVQPGPHA-MYARVRQVESNPLYQGTASSADVALV 128
Query: 415 QLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWGR-GEPALGPG----ALLEAELLGG 469
+L PV + PVCLP P F G C + WG E L P L ++
Sbjct: 129 ELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDT 188
Query: 470 WWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRD 529
C+ LY + P + + A E+ + +C DS L+C +W AG+
Sbjct: 189 PKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVIS 248
Query: 530 FPSGCL---RPRAFFPLQTHGPWISHV 553
+ GC RP + + H WI +
Sbjct: 249 WGEGCARQNRPGVYIRVTAHHNWIHRI 275
Score = 83.2 bits (204), Expect = 9e-16
Identities = 69/242 (28%), Positives = 102/242 (42%), Gaps = 32/242 (13%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW + G C G L+A WVL A HC T++ +V LG A P H
Sbjct: 46 WPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSL--YQVLLG-ARQLVQPGPHA 102
Query: 661 V---SRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAGI--PPGASCWVLG 715
+ R V S L Q +AL+EL + V + LP+CL + G +CWV G
Sbjct: 103 MYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVIFETGMNCWVTG 162
Query: 716 WKEPQD-------RVPVAAAVSILTQRICDCLYQ-----GILPP----GTLCVLYAEGQE 759
W P + R+ AV I+ C+ LY G P LC + EG++
Sbjct: 163 WGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKK 222
Query: 760 NRCEMTSAPPLLCQMTEGSWILVGM-------AVQGSRELFAAIGPEEAWISQTVGEANF 812
+ C+ S PL+C + + SW+ G+ A Q ++ + WI + + + F
Sbjct: 223 DACKGDSGGPLVCLVGQ-SWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIHRIIPKLQF 281
Query: 813 LP 814
P
Sbjct: 282 QP 283
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 215 bits (547), Expect = 2e-55
Identities = 112/260 (43%), Positives = 155/260 (59%), Gaps = 12/260 (4%)
Query: 32 EPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMT 91
+ E DCG PS+RIVGG+ + G WPWQ SL G HICGG+LIA WV++AAHCF
Sbjct: 562 DEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQE 621
Query: 92 NGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASL 151
+ ++ W+V LG Q+ G + V+ +++ + + D+ALL+L P
Sbjct: 622 D-SMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVR 680
Query: 152 GPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYS 211
AV PVCLP SH F G CW TGWG ++E P+ LQ+V+++L+ + C +Y
Sbjct: 681 SAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISN--ALQKVDVQLIPQDLCSEVY- 737
Query: 212 QPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGCGRR 270
Q+ P MLCAGY +G++D CQGDSGGPLVC+ GRWF AG+ S+G GCGR
Sbjct: 738 -------RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRP 790
Query: 271 NRPGVFTAVATYEAWIREQV 290
N GV+T + +WI++ V
Sbjct: 791 NYFGVYTRITGVISWIQQVV 810
Score = 113 bits (283), Expect = 7e-25
Identities = 77/223 (34%), Positives = 108/223 (48%), Gaps = 17/223 (7%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G G WPW+A + V G C GAL+++ WV+ A CF + + + + + +V
Sbjct: 580 GAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQ 639
Query: 386 PSRPRAE---RVARLVQHENASWDNAS-DLALLQLRTPVNLSAASRPVCLPHPEHYFLPG 441
SR E +V+RL+ H D+ D+ALLQL PV SAA RPVCLP H+F PG
Sbjct: 640 NSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPG 699
Query: 442 SRCRLARWG---RGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQ 498
C + WG G P ++ +L+ C +Y Q P LC Y+
Sbjct: 700 LHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVT--------PRMLCAGYR 751
Query: 499 EKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGCLRPRAF 540
K + +C DS L+C+ G WFLAG+ + GC RP F
Sbjct: 752 -KGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYF 793
Score = 105 bits (262), Expect = 2e-22
Identities = 70/225 (31%), Positives = 109/225 (48%), Gaps = 24/225 (10%)
Query: 584 EHGACGLRLEAAPV--GVL-----WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPG 636
EH CGL+ ++ + G + WPW A + V G +C G L+A WV+ A HC
Sbjct: 564 EHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDS 623
Query: 637 STTVPYIEVYLGRAGASSLPQGH---QVSRLVISIRLPQHL--GLRPPLALLELSSRVEP 691
+ V+LG+ +S G +VSRL++ P H +ALL+L V
Sbjct: 624 MASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLH---PYHEEDSHDYDVALLQLDHPVVR 680
Query: 692 SPSALPICLHPAG---IPPGASCWVLGWKEPQDRVPVAAA-----VSILTQRICDCLYQG 743
S + P+CL PA PG CW+ GW ++ P++ A V ++ Q +C +Y+
Sbjct: 681 SAAVRPVCL-PARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRY 739
Query: 744 ILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788
+ P LC Y +G+++ C+ S PL+C+ G W L G+ G
Sbjct: 740 QVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWG 784
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 210 bits (534), Expect = 5e-54
Identities = 113/264 (42%), Positives = 153/264 (57%), Gaps = 17/264 (6%)
Query: 32 EPEDLDCGRPE--PSARIVGGSNAQPGTWPWQVSLHH-GGGHICGGSLIAPSWVLSAAHC 88
+ +D DCG AR+VGG++A G WPWQVSLH G GHICG SLI+P+W++SAAHC
Sbjct: 598 DEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHC 657
Query: 89 FMTNGTLEPA--AEWSVLLGVHSQDG-PLDGAHTRAVAAIVVPANYSQVELGADLALLRL 145
++ + + +W+ LG+H Q G R + I+ ++ D+ALL L
Sbjct: 658 YIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLEL 717
Query: 146 ASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEAT 205
PA V P+CLP ASH F G A W TGWG Q L +LQ+ E+R++ + T
Sbjct: 718 EKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGAL--ILQKGEIRVINQTT 775
Query: 206 CQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPL-VCEEGGRWFQAGITSFG 264
C+ L Q QI P M+C G+ G D+CQGDSGGPL E GR FQAG+ S+G
Sbjct: 776 CENLLPQ--------QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWG 827
Query: 265 FGCGRRNRPGVFTAVATYEAWIRE 288
GC +RN+PGV+T + + WI+E
Sbjct: 828 DGCAQRNKPGVYTRLPLFRDWIKE 851
Score = 73.2 bits (178), Expect = 1e-12
Identities = 66/242 (27%), Positives = 101/242 (41%), Gaps = 31/242 (12%)
Query: 332 GAWPWEAQVMVPGS-RPCHGALVSESWVLAPASCFLDPNSSD-SPPRDLDAWRVLLPSRP 389
G WPW+ + G C +L+S +W+++ A C++D S P A+ L
Sbjct: 624 GEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQ 683
Query: 390 RA------ERVARLVQH---ENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLP 440
R+ R+ R++ H + ++D D+ALL+L P S+ RP+CLP H F
Sbjct: 684 RSAPGVQERRLKRIISHPFFNDFTFDY--DIALLELEKPAEYSSMVRPICLPDASHVFPA 741
Query: 441 GSRCRLARWGRGEPALGPGALL----EAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496
G + WG + G GAL+ E ++ C L +Q P +C
Sbjct: 742 GKAIWVTGWGHTQYG-GTGALILQKGEIRVINQTTCENLLPQQ--------ITPRMMCVG 792
Query: 497 YQEKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWISH 552
+ V SC DS L E +G F AG+ + GC +P + L WI
Sbjct: 793 FL-SGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKE 851
Query: 553 VT 554
T
Sbjct: 852 NT 853
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/203 (27%), Positives = 80/203 (39%), Gaps = 16/203 (7%)
Query: 601 WPWLAEVHVAGD-RVCTGILLAPGWVLAATHCVL-----RPGSTTVPYIEVYLGRAGASS 654
WPW +H G +C L++P W+++A HC + R T + L S
Sbjct: 626 WPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRS 685
Query: 655 LPQGHQVSRL--VISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGAS 710
P G Q RL +IS +ALLEL E S PICL A P G +
Sbjct: 686 AP-GVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKA 744
Query: 711 CWVLGWKEPQ-----DRVPVAAAVSILTQRICDCLYQGILPPGTLCVLYAEGQENRCEMT 765
WV GW Q + + ++ Q C+ L + P +CV + G + C+
Sbjct: 745 IWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGD 804
Query: 766 SAPPLLCQMTEGSWILVGMAVQG 788
S PL +G G+ G
Sbjct: 805 SGGPLSSVEADGRIFQAGVVSWG 827
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 204 bits (520), Expect = 2e-52
Identities = 109/252 (43%), Positives = 144/252 (57%), Gaps = 17/252 (6%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CG + RIVGG+ A WPWQVSLH G HICGG+LI WVL+AAHCF T E
Sbjct: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFV--TREK 374
Query: 98 AAE-WSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVW 156
E W V G + + A ++A I++ +NY+ E D+AL+RL+ P +L +
Sbjct: 375 VLEGWKVYAGTSNLHQLPEAA---SIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIH 431
Query: 157 PVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQ--CLYSQPG 214
P CLP F CW TG+G +E D P+ L+EV++ L+ C +Y
Sbjct: 432 PACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVYDS-- 488
Query: 215 PFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPG 274
+ P M+CAG G RD+CQGDSGGPLVCE+ RW+ AG+TS+G GCG+RN+PG
Sbjct: 489 ------YLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPG 542
Query: 275 VFTAVATYEAWI 286
V+T V WI
Sbjct: 543 VYTKVTEVLPWI 554
Score = 75.1 bits (183), Expect = 3e-13
Identities = 55/219 (25%), Positives = 89/219 (40%), Gaps = 19/219 (8%)
Query: 588 CGLRLEAAPV--GVL-----WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTV 640
CGLR + G L WPW +H +C G L+ WVL A HC +
Sbjct: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376
Query: 641 PYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICL 700
+VY G + LP+ ++ ++I+ +AL+ LS + S P CL
Sbjct: 377 EGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEED-DYDIALMRLSKPLTLSAHIHPACL 435
Query: 701 --HPAGIPPGASCWVLGW---KEPQDRVPV---AAAVSILTQRICD--CLYQGILPPGTL 750
H +CW+ G+ +E D+ V+++ + C+ +Y L P +
Sbjct: 436 PMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMM 495
Query: 751 CVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQGS 789
C G + C+ S PL+C+ W L G+ G+
Sbjct: 496 CAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGT 533
Score = 71.2 bits (173), Expect = 4e-12
Identities = 56/230 (24%), Positives = 93/230 (40%), Gaps = 25/230 (10%)
Query: 334 WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL-----LPSR 388
WPW+ + + C G L+ WVL A CF + L+ W+V L
Sbjct: 337 WPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTRE-----KVLEGWKVYAGTSNLHQL 391
Query: 389 PRAERVARLVQHEN-ASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLA 447
P A +A ++ + N ++ D+AL++L P+ LSA P CLP F C +
Sbjct: 392 PEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWIT 451
Query: 448 RWGRGEPALGPGA----LLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEEV 503
+G+ + ++ L+ C+ P +C A +
Sbjct: 452 GFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLT------PRMMC-AGDLRGGR 504
Query: 504 GSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC---LRPRAFFPLQTHGPWI 550
SC DS L+C++ W+LAG+ + +GC +P + + PWI
Sbjct: 505 DSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
>gi|11545839 protease, serine, 22 [Homo sapiens]
Length = 317
Score = 204 bits (519), Expect = 3e-52
Identities = 107/259 (41%), Positives = 143/259 (55%), Gaps = 12/259 (4%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CG+P+ R+VGG ++ WPW VS+ G H C GSL+ WV++AAHCF N L
Sbjct: 41 CGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDN--LNK 98
Query: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELG-ADLALLRLASPASLGPAVW 156
+SVLLG P + VA + YS E AD+AL+RL V
Sbjct: 99 PYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVL 158
Query: 157 PVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLY---SQP 213
P+CLP AS T CW +GWG +Q+ PLP P LQ++++ ++ C LY +
Sbjct: 159 PICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQ 218
Query: 214 GPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRP 273
GP I MLCAGY EG RD C GDSGGPL+C+ G W AGI S+G GC RNRP
Sbjct: 219 GP------ITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRP 272
Query: 274 GVFTAVATYEAWIREQVMG 292
GV+ +++ + +W+ + V G
Sbjct: 273 GVYISLSAHRSWVEKIVQG 291
Score = 111 bits (278), Expect = 2e-24
Identities = 76/246 (30%), Positives = 109/246 (44%), Gaps = 16/246 (6%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDP-NSSDSPPRDLDAWRVL 384
G+ WPW + G+ C G+L++ WV+ A CF D N L AW++
Sbjct: 53 GEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLG 112
Query: 385 LP-SRPRAERVARLVQHENASWDN--ASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPG 441
P SR + VA + H SW +D+AL++L + S P+CLP + P
Sbjct: 113 NPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPN 172
Query: 442 SRCRLARWGR---GEPALGPGAL--LEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496
+ C ++ WG G P P L L+ ++ C LY R P+ D LC
Sbjct: 173 THCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITED---MLCAG 229
Query: 497 YQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWISHV 553
Y E E +C DS L+CQ +G W LAGI + GC RP + L H W+ +
Sbjct: 230 YLEGER-DACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKI 288
Query: 554 TRGAYL 559
+G L
Sbjct: 289 VQGVQL 294
Score = 98.2 bits (243), Expect = 3e-20
Identities = 67/233 (28%), Positives = 103/233 (44%), Gaps = 30/233 (12%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW+ + G C G LL WV+ A HC + PY+ L A P G +
Sbjct: 61 WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCF--KDNLNKPYLFSVLLGAWQLGNP-GSR 117
Query: 661 VSRLVISIRLPQHL-----GLRPPLALLELSSRVEPSPSALPICLHPAGI--PPGASCWV 713
++ ++ P + G +AL+ L ++ S LPICL A I PP CW+
Sbjct: 118 SQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWI 177
Query: 714 LGWKEPQDRVPV-------AAAVSILTQRICDCLY-----QGILPPGTLCVLYAEGQENR 761
GW QD VP+ V I+ +C LY QG + LC Y EG+ +
Sbjct: 178 SGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDA 237
Query: 762 CEMTSAPPLLCQMTEGSWILVGM-------AVQGSRELFAAIGPEEAWISQTV 807
C S PL+CQ+ +G+W+L G+ A + ++ ++ +W+ + V
Sbjct: 238 CLGDSGGPLMCQV-DGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIV 289
>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
Length = 318
Score = 202 bits (513), Expect = 1e-51
Identities = 108/264 (40%), Positives = 149/264 (56%), Gaps = 10/264 (3%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CG E A + GG + G WPWQ SL H CGGSL++ WVLSAAHCF +
Sbjct: 46 CGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYY--- 102
Query: 98 AAEWSVLLG-VHSQDGP--LDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPA 154
+EW+V LG + S+ P L +R ++ + L D+ALLRLAS +
Sbjct: 103 PSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVTYNAY 162
Query: 155 VWPVCLPRASHRFVHGTACWATGWGDVQEAD-PLPLPWVLQEVELRLLGEATCQCLYSQP 213
+ P+C+ ++ FVH CW TGWG + + PLP P+ L+E ++ +L C L+ QP
Sbjct: 163 IQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQP 222
Query: 214 GPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRP 273
++ I M CAG +G DTC+GDSGGPLVC++ G W+Q GI S+G CG+ NRP
Sbjct: 223 SSRSM---IWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNRP 279
Query: 274 GVFTAVATYEAWIREQVMGSEPGP 297
GV+T ++ Y WIR + S P P
Sbjct: 280 GVYTNISVYFHWIRRVMSHSTPRP 303
Score = 77.4 bits (189), Expect = 5e-14
Identities = 71/262 (27%), Positives = 111/262 (42%), Gaps = 30/262 (11%)
Query: 314 REENC----TIALPECGKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPN 369
REE C AL G G WPW+A + + C G+L+S WVL+ A CF
Sbjct: 42 REEACGHREIHALVAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCF---- 97
Query: 370 SSDSPPRDLDAWRVLLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPV 420
P + L SRP +V ++ + +A +D+ALL+L + V
Sbjct: 98 QKHYYPSEWTVQLGELTSRPTPWNLRAYSSRYKVQDIIVNPDALGVLRNDIALLRLASSV 157
Query: 421 NLSAASRPVCLPHPEHYFLPGSRCRLARWG----RGEPALGPGALLEAE--LLGGWWCHC 474
+A +P+C+ F+ C + WG G P P L EA+ +L C+
Sbjct: 158 TYNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNY 217
Query: 475 LYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534
L+ Q ++ + D ++ A E V +C DS L+C ++G W+ GI + C
Sbjct: 218 LF-EQPSSRSMIWD---SMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDC 273
Query: 535 ---LRPRAFFPLQTHGPWISHV 553
RP + + + WI V
Sbjct: 274 GQPNRPGVYTNISVYFHWIRRV 295
Score = 64.3 bits (155), Expect = 5e-10
Identities = 59/214 (27%), Positives = 88/214 (41%), Gaps = 35/214 (16%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLR---PGSTTVPYIEVYLGRAGASSLP- 656
WPW A + + C G LL+ WVL+A HC + P T V LG + P
Sbjct: 66 WPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYPSEWT-----VQLGELTSRPTPW 120
Query: 657 ------QGHQVSRLVISIRLPQHLG-LRPPLALLELSSRVEPSPSALPICLHPA--GIPP 707
++V ++++ P LG LR +ALL L+S V + PIC+ +
Sbjct: 121 NLRAYSSRYKVQDIIVN---PDALGVLRNDIALLRLASSVTYNAYIQPICIESSTFNFVH 177
Query: 708 GASCWVLGW--------KEPQDRVPVAAAVSILTQRICDCLYQ-----GILPPGTLCVLY 754
CWV GW P A V+IL C+ L++ ++ C
Sbjct: 178 RPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGA 237
Query: 755 AEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788
+G + C+ S PL+C +G W VG+ G
Sbjct: 238 EDGSVDTCKGDSGGPLVCD-KDGLWYQVGIVSWG 270
>gi|5803197 testisin isoform 1 [Homo sapiens]
Length = 314
Score = 202 bits (513), Expect = 1e-51
Identities = 104/281 (37%), Positives = 158/281 (56%), Gaps = 11/281 (3%)
Query: 28 PTQEEPEDLD--CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSA 85
P +E L CGR ++RIVGG +A+ G WPWQ SL H+CG SL++ W L+A
Sbjct: 21 PESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTA 80
Query: 86 AHCFMTNGTLEPAAEWSVLLGVHSQDGP---LDGAHTRAVAAIVVPANYSQVELGADLAL 142
AHCF T L + W V G + L +TR + + + D+AL
Sbjct: 81 AHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIAL 140
Query: 143 LRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLG 202
++L++P + + P+CL ++ F + T CW TGWG ++E + LP P LQEV++ ++
Sbjct: 141 VKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIIN 200
Query: 203 EATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITS 262
+ C L+ + ++ I M+CAG +G +D C GDSGGPL C + G W+Q G+ S
Sbjct: 201 NSMCNHLFLK---YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVS 257
Query: 263 FGFGCGRRNRPGVFTAVATYEAWIRE---QVMGSEPGPAFP 300
+G GCGR NRPGV+T ++ + WI++ Q S+P P++P
Sbjct: 258 WGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWP 298
Score = 66.2 bits (160), Expect = 1e-10
Identities = 59/245 (24%), Positives = 95/245 (38%), Gaps = 28/245 (11%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV-- 383
G+ G WPW+ + + S C +L+S W L A CF + S D W V
Sbjct: 45 GEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCF----ETYSDLSDPSGWMVQF 100
Query: 384 -LLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPH 433
L S P V+ + ++ D+AL++L PV + +P+CL
Sbjct: 101 GQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQA 160
Query: 434 PEHYFLPGSRCRLARWG---RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGD 488
F + C + WG E P L E + ++ C+ L+ + + GD
Sbjct: 161 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 220
Query: 489 PPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPR---AFFPLQT 545
+ A + +C+ DS L C + G W+ G+ + GC RP + +
Sbjct: 221 ----MVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISH 276
Query: 546 HGPWI 550
H WI
Sbjct: 277 HFEWI 281
Score = 64.7 bits (156), Expect = 3e-10
Identities = 75/285 (26%), Positives = 115/285 (40%), Gaps = 45/285 (15%)
Query: 575 ETQTCPPHTEHGACGLRL--------EAAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVL 626
E+Q P + G CG R+ E A +G WPW + + VC LL+ W L
Sbjct: 22 ESQEAAPLS--GPCGRRVITSRIVGGEDAELG-RWPWQGSLRLWDSHVCGVSLLSHRWAL 78
Query: 627 AATHCVLRPGSTTVPY-IEVYLGRAGASSLP-----QGHQVSRLVISIRL-PQHLGLRP- 678
A HC + P V G+ +S+P Q + V +I L P++LG P
Sbjct: 79 TAAHCFETYSDLSDPSGWMVQFGQ--LTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPY 136
Query: 679 PLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGW---KE----PQDRVPVAAAV 729
+AL++LS+ V + PICL + CWV GW KE P V
Sbjct: 137 DIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQV 196
Query: 730 SILTQRICDCL-----YQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGM 784
+I+ +C+ L ++ + +C A+G ++ C S PL C G W +G+
Sbjct: 197 AIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACN-KNGLWYQIGV 255
Query: 785 AVQG-------SRELFAAIGPEEAWISQTVGEANFLPPSGSPHWP 822
G ++ I WI + + ++ P P WP
Sbjct: 256 VSWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQP--DPSWP 298
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 198 bits (504), Expect = 2e-50
Identities = 104/281 (37%), Positives = 159/281 (56%), Gaps = 13/281 (4%)
Query: 28 PTQEEPEDLD--CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSA 85
P +E L CGR ++RIVGG +A+ G WPWQ SL H+CG SL++ W L+A
Sbjct: 21 PESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTA 80
Query: 86 AHCFMTNGTLEPAAEWSVLLGVHSQDGP---LDGAHTRAVAAIVVPANYSQVELGADLAL 142
AHCF T+ L + W V G + L +TR + + + D+AL
Sbjct: 81 AHCFETD--LSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIAL 138
Query: 143 LRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLG 202
++L++P + + P+CL ++ F + T CW TGWG ++E + LP P LQEV++ ++
Sbjct: 139 VKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIIN 198
Query: 203 EATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITS 262
+ C L+ + ++ I M+CAG +G +D C GDSGGPL C + G W+Q G+ S
Sbjct: 199 NSMCNHLFLK---YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVS 255
Query: 263 FGFGCGRRNRPGVFTAVATYEAWIRE---QVMGSEPGPAFP 300
+G GCGR NRPGV+T ++ + WI++ Q S+P P++P
Sbjct: 256 WGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWP 296
Score = 65.9 bits (159), Expect = 2e-10
Identities = 58/245 (23%), Positives = 95/245 (38%), Gaps = 30/245 (12%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV-- 383
G+ G WPW+ + + S C +L+S W L A CF ++ D W V
Sbjct: 45 GEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCF------ETDLSDPSGWMVQF 98
Query: 384 -LLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPH 433
L S P V+ + ++ D+AL++L PV + +P+CL
Sbjct: 99 GQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQA 158
Query: 434 PEHYFLPGSRCRLARWG---RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGD 488
F + C + WG E P L E + ++ C+ L+ + + GD
Sbjct: 159 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD 218
Query: 489 PPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPR---AFFPLQT 545
+ A + +C+ DS L C + G W+ G+ + GC RP + +
Sbjct: 219 ----MVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISH 274
Query: 546 HGPWI 550
H WI
Sbjct: 275 HFEWI 279
Score = 65.5 bits (158), Expect = 2e-10
Identities = 75/284 (26%), Positives = 116/284 (40%), Gaps = 45/284 (15%)
Query: 575 ETQTCPPHTEHGACGLRL--------EAAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVL 626
E+Q P + G CG R+ E A +G WPW + + VC LL+ W L
Sbjct: 22 ESQEAAPLS--GPCGRRVITSRIVGGEDAELG-RWPWQGSLRLWDSHVCGVSLLSHRWAL 78
Query: 627 AATHCVLRPGSTTVPYIEVYLGRAGASSLP-----QGHQVSRLVISIRL-PQHLGLRP-P 679
A HC S ++ V G+ +S+P Q + V +I L P++LG P
Sbjct: 79 TAAHCFETDLSDPSGWM-VQFGQ--LTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYD 135
Query: 680 LALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGW---KE----PQDRVPVAAAVS 730
+AL++LS+ V + PICL + CWV GW KE P V+
Sbjct: 136 IALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVA 195
Query: 731 ILTQRICDCL-----YQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMA 785
I+ +C+ L ++ + +C A+G ++ C S PL C G W +G+
Sbjct: 196 IINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACN-KNGLWYQIGVV 254
Query: 786 VQG-------SRELFAAIGPEEAWISQTVGEANFLPPSGSPHWP 822
G ++ I WI + + ++ P P WP
Sbjct: 255 SWGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQP--DPSWP 296
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 191 bits (486), Expect = 2e-48
Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 21/282 (7%)
Query: 12 LVISPIPGAFQDSALSPTQEEPEDLDCGRP----EPSARIVGGSNAQPGTWPWQVSLHHG 67
L+++P QDS + + + CG+ + + +IVGGSNA+ G WPW V L++G
Sbjct: 749 LILTPSQQCLQDSLI---RLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYG 805
Query: 68 GGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHT--RAVAAI 125
G +CG SL++ W++SAAHC + LEP+ +W+ +LG+H + L T R + I
Sbjct: 806 GRLLCGASLVSSDWLVSAAHC-VYGRNLEPS-KWTAILGLHMKSN-LTSPQTVPRLIDEI 862
Query: 126 VVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEAD 185
V+ +Y++ D+A++ L + + P+CLP + F G C GWG V
Sbjct: 863 VINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQG 922
Query: 186 PLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGG 245
+LQE ++ LL CQ Q +N+T M+CAGY EG D+CQGDSGG
Sbjct: 923 TTAN--ILQEADVPLLSNERCQ---QQMPEYNIT----ENMICAGYEEGGIDSCQGDSGG 973
Query: 246 PLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIR 287
PL+C+E RWF AG+TSFG+ C NRPGV+ V+ + WI+
Sbjct: 974 PLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1015
Score = 87.4 bits (215), Expect = 5e-17
Identities = 70/245 (28%), Positives = 101/245 (41%), Gaps = 38/245 (15%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G + GAWPW + G C +LVS W+++ A C N S W +L
Sbjct: 788 GSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSK------WTAIL 841
Query: 386 PSRPRA-----ERVARLVQ------HENASWDNASDLALLQLRTPVNLSAASRPVCLPHP 434
++ + V RL+ H N + +D+A++ L VN + +P+CLP
Sbjct: 842 GLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKD-NDIAMMHLEFKVNYTDYIQPICLPEE 900
Query: 435 EHYFLPGSRCRLARWG----RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGD 488
F PG C +A WG +G A L EA+ LL C +P
Sbjct: 901 NQVFPPGRNCSIAGWGTVVYQGTTA---NILQEADVPLLSNERCQ-------QQMPEYNI 950
Query: 489 PPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQT 545
+ +C Y+E + SC DS L+CQE WFLAG+ F C RP + +
Sbjct: 951 TENMICAGYEE-GGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSR 1009
Query: 546 HGPWI 550
WI
Sbjct: 1010 FTEWI 1014
Score = 72.8 bits (177), Expect = 1e-12
Identities = 60/230 (26%), Positives = 94/230 (40%), Gaps = 32/230 (13%)
Query: 585 HGACGLRLEAAPVGV-----------LWPWLAEVHVAGDRVCTGILLAPGWVLAATHCV- 632
H +CG +L A + WPW+ ++ G +C L++ W+++A HCV
Sbjct: 769 HKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVY 828
Query: 633 ---LRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLR---PPLALLELS 686
L P T LG S+L V RL+ I + H R +A++ L
Sbjct: 829 GRNLEPSKWT-----AILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLE 883
Query: 687 SRVEPSPSALPICLHPAG--IPPGASCWVLGW-----KEPQDRVPVAAAVSILTQRIC-D 738
+V + PICL PPG +C + GW + + A V +L+ C
Sbjct: 884 FKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQ 943
Query: 739 CLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788
+ + + +C Y EG + C+ S PL+CQ W L G+ G
Sbjct: 944 QMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQ-ENNRWFLAGVTSFG 992
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 189 bits (479), Expect = 1e-47
Identities = 105/255 (41%), Positives = 137/255 (53%), Gaps = 15/255 (5%)
Query: 38 CG-RPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLE 96
CG R S+RIVGG+ + WPWQ SL G H+CGGS+I P W+++AAHC L
Sbjct: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD---LY 263
Query: 97 PAAEWSVLLGVHSQ-DGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAV 155
W++ +G+ S D P A + V IV + Y LG D+AL++LA P + +
Sbjct: 264 LPKSWTIQVGLVSLLDNP---APSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMI 320
Query: 156 WPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGP 215
PVCLP + F G CW +GWG ++ P VL + L+ C G
Sbjct: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASP-VLNHAAVPLISNKICNHRDVYGGI 379
Query: 216 FNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGV 275
I P MLCAGY G D+CQGDSGGPLVC+E W G TSFG GC N+PGV
Sbjct: 380 ------ISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGV 433
Query: 276 FTAVATYEAWIREQV 290
+T V ++ WI EQ+
Sbjct: 434 YTRVTSFLDWIHEQM 448
Score = 86.3 bits (212), Expect = 1e-16
Identities = 63/197 (31%), Positives = 92/197 (46%), Gaps = 21/197 (10%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCV---LRPGSTTVPYIEVYLGRAGASSLPQ 657
WPW A + G +C G ++ P W++ A HCV P S T+ V L A S
Sbjct: 228 WPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPS--- 284
Query: 658 GHQVSRLVISIRL-PQHLGLRPPLALLELSSRVEPSPSALPICL--HPAGIPPGASCWVL 714
H V ++V + P+ LG +AL++L+ + + P+CL P G CW
Sbjct: 285 -HLVEKIVYHSKYKPKRLG--NDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTS 341
Query: 715 GWKEPQDRVPVA------AAVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCEMTS 766
GW +D A AAV +++ +IC+ +Y GI+ P LC Y G + C+ S
Sbjct: 342 GWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDS 401
Query: 767 APPLLCQMTEGSWILVG 783
PL+CQ W LVG
Sbjct: 402 GGPLVCQ-ERRLWKLVG 417
Score = 78.6 bits (192), Expect = 2e-14
Identities = 63/240 (26%), Positives = 93/240 (38%), Gaps = 46/240 (19%)
Query: 334 WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV------LLPS 387
WPW+A + G C G++++ W++ A C D S W + LL +
Sbjct: 228 WPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-------WTIQVGLVSLLDN 280
Query: 388 RPRAERVARLVQHENASWDN-ASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRL 446
+ V ++V H +D+AL++L P+ + +PVCLP+ E F G C
Sbjct: 281 PAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT 340
Query: 447 ARWGRGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGD-------------PPHAL 493
+ WG E G + + AAVPL + P L
Sbjct: 341 SGWGATEDGAGDASPV---------------LNHAAVPLISNKICNHRDVYGGIISPSML 385
Query: 494 CPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWI 550
C Y V SC DS L+CQE W L G F GC +P + + + WI
Sbjct: 386 CAGYL-TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 187 bits (475), Expect = 4e-47
Identities = 110/277 (39%), Positives = 138/277 (49%), Gaps = 23/277 (8%)
Query: 37 DCGRPE-PSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTL 95
DCGR + P RIVGG + G WPWQVSL + G H+CGGSL++ WVL+AAHCF +
Sbjct: 152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRV 211
Query: 96 EPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANY------SQVELGADLALLRLASPA 149
+ W V G +Q P V A+V Y + E D+AL+ L+SP
Sbjct: 212 --LSRWRVFAGAVAQASP--HGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPL 267
Query: 150 SLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCL 209
L + PVCLP A V G C TGWG+ Q VLQE + ++ C
Sbjct: 268 PLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYG--QQAGVLQEARVPIISNDVCN-- 323
Query: 210 YSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEG----GRWFQAGITSFGF 265
G QI P M CAGYPEG D CQGDSGGP VCE+ RW GI S+G
Sbjct: 324 ----GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
Query: 266 GCGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFPTQ 302
GC +PGV+T V+ + WI + + TQ
Sbjct: 380 GCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ 416
Score = 81.3 bits (199), Expect = 4e-15
Identities = 70/253 (27%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G+ G WPW+ + G+ C G+L+S WVL A CF + N R L WRV
Sbjct: 166 GRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERN------RVLSRWRVFA 219
Query: 386 PSRPRAE------RVARLVQH-------ENASWDNASDLALLQLRTPVNLSAASRPVCLP 432
+ +A V +V H + S +N++D+AL+ L +P+ L+ +PVCLP
Sbjct: 220 GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
Query: 433 HPEHYFLPGSRCRLARWGR----GEPALGPGALLEAE--LLGGWWCH--CLYGRQGAAVP 484
+ G C + WG G+ A G L EA ++ C+ YG Q
Sbjct: 280 AAGQALVDGKICTVTGWGNTQYYGQQA---GVLQEARVPIISNDVCNGADFYGNQ----- 331
Query: 485 LPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEE----GTWFLAGIRDFPSGCL---RP 537
P C Y E + +C DS +C++ W L GI + +GC +P
Sbjct: 332 ---IKPKMFCAGYPE-GGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
Query: 538 RAFFPLQTHGPWI 550
+ + WI
Sbjct: 388 GVYTKVSDFREWI 400
Score = 66.6 bits (161), Expect = 9e-11
Identities = 59/209 (28%), Positives = 87/209 (41%), Gaps = 23/209 (11%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW + G +C G LL+ WVL A HC + + V+ G A A + P G Q
Sbjct: 174 WPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-FPERNRVLSRWRVFAG-AVAQASPHGLQ 231
Query: 661 VSRLVISIRLPQHLGLRPP--------LALLELSSRVEPSPSALPICLHPAG--IPPGAS 710
+ + + +L R P +AL+ LSS + + P+CL AG + G
Sbjct: 232 LGVQAV-VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKI 290
Query: 711 CWVLGWKE-----PQDRVPVAAAVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCE 763
C V GW Q V A V I++ +C+ Y + P C Y EG + C+
Sbjct: 291 CTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQ 350
Query: 764 MTSAPPLLCQ---MTEGSWILVGMAVQGS 789
S P +C+ W L G+ G+
Sbjct: 351 GDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 187 bits (475), Expect = 4e-47
Identities = 110/277 (39%), Positives = 138/277 (49%), Gaps = 23/277 (8%)
Query: 37 DCGRPE-PSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTL 95
DCGR + P RIVGG + G WPWQVSL + G H+CGGSL++ WVL+AAHCF +
Sbjct: 152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRV 211
Query: 96 EPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANY------SQVELGADLALLRLASPA 149
+ W V G +Q P V A+V Y + E D+AL+ L+SP
Sbjct: 212 --LSRWRVFAGAVAQASP--HGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPL 267
Query: 150 SLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCL 209
L + PVCLP A V G C TGWG+ Q VLQE + ++ C
Sbjct: 268 PLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYG--QQAGVLQEARVPIISNDVCN-- 323
Query: 210 YSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEG----GRWFQAGITSFGF 265
G QI P M CAGYPEG D CQGDSGGP VCE+ RW GI S+G
Sbjct: 324 ----GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
Query: 266 GCGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFPTQ 302
GC +PGV+T V+ + WI + + TQ
Sbjct: 380 GCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ 416
Score = 81.3 bits (199), Expect = 4e-15
Identities = 70/253 (27%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G+ G WPW+ + G+ C G+L+S WVL A CF + N R L WRV
Sbjct: 166 GRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERN------RVLSRWRVFA 219
Query: 386 PSRPRAE------RVARLVQH-------ENASWDNASDLALLQLRTPVNLSAASRPVCLP 432
+ +A V +V H + S +N++D+AL+ L +P+ L+ +PVCLP
Sbjct: 220 GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
Query: 433 HPEHYFLPGSRCRLARWGR----GEPALGPGALLEAE--LLGGWWCH--CLYGRQGAAVP 484
+ G C + WG G+ A G L EA ++ C+ YG Q
Sbjct: 280 AAGQALVDGKICTVTGWGNTQYYGQQA---GVLQEARVPIISNDVCNGADFYGNQ----- 331
Query: 485 LPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEE----GTWFLAGIRDFPSGCL---RP 537
P C Y E + +C DS +C++ W L GI + +GC +P
Sbjct: 332 ---IKPKMFCAGYPE-GGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
Query: 538 RAFFPLQTHGPWI 550
+ + WI
Sbjct: 388 GVYTKVSDFREWI 400
Score = 66.6 bits (161), Expect = 9e-11
Identities = 59/209 (28%), Positives = 87/209 (41%), Gaps = 23/209 (11%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW + G +C G LL+ WVL A HC + + V+ G A A + P G Q
Sbjct: 174 WPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-FPERNRVLSRWRVFAG-AVAQASPHGLQ 231
Query: 661 VSRLVISIRLPQHLGLRPP--------LALLELSSRVEPSPSALPICLHPAG--IPPGAS 710
+ + + +L R P +AL+ LSS + + P+CL AG + G
Sbjct: 232 LGVQAV-VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKI 290
Query: 711 CWVLGWKE-----PQDRVPVAAAVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCE 763
C V GW Q V A V I++ +C+ Y + P C Y EG + C+
Sbjct: 291 CTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQ 350
Query: 764 MTSAPPLLCQ---MTEGSWILVGMAVQGS 789
S P +C+ W L G+ G+
Sbjct: 351 GDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 187 bits (475), Expect = 4e-47
Identities = 112/291 (38%), Positives = 146/291 (50%), Gaps = 24/291 (8%)
Query: 14 ISPIPGAFQDSALSP----TQEEPEDL---DCGRPEPSARIVGGSNAQPGTWPWQVSLHH 66
+SP G F + A P T + L +CG ++RIVGG + PG WPWQ S+
Sbjct: 178 LSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVAL 237
Query: 67 GGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGV--HSQDGPLDGAHTRAVAA 124
G H CGGS++AP WV++AAHC M + L + W V G+ HS P GA V
Sbjct: 238 GFRHTCGGSVLAPRWVVTAAHC-MHSFRLARLSSWRVHAGLVSHSAVRPHQGA---LVER 293
Query: 125 IVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEA 184
I+ YS D+ALLRL + + V VCLP F G+ CW +GWG +
Sbjct: 294 IIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPS 353
Query: 185 DPLPLPWVLQEVELRLLGEATCQ--CLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGD 242
+LQ+ + L C C+YS + P MLCAGY +GR D CQGD
Sbjct: 354 HTYSSD-MLQDTVVPLFSTQLCNSSCVYSGA--------LTPRMLCAGYLDGRADACQGD 404
Query: 243 SGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGS 293
SGGPLVC +G W G+ S+G GC N PGV+ VA + WI + S
Sbjct: 405 SGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDS 455
Score = 89.7 bits (221), Expect = 1e-17
Identities = 77/257 (29%), Positives = 109/257 (42%), Gaps = 46/257 (17%)
Query: 312 EPREENCT------IALPECGKAP-----------RPGAWPWEAQVMVPGSRPCHGALVS 354
+PR NCT + ECG P PG WPW+A V + C G++++
Sbjct: 191 QPRN-NCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLA 249
Query: 355 ESWVLAPASCFLDPNSSDSPPRDLDAWRVLL------PSRP-RAERVARLVQHENASWDN 407
WV+ A C + L +WRV RP + V R++ H S N
Sbjct: 250 PRWVVTAAHCMHSFRLAR-----LSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQN 304
Query: 408 AS-DLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPA-LGPGALLE-- 463
D+ALL+L+T +N S VCLP E +F GSRC ++ WG P+ +L+
Sbjct: 305 HDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDT 364
Query: 464 -AELLGGWWCH--CLYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEG 520
L C+ C+Y GA P LC Y + +C DS L+C +
Sbjct: 365 VVPLFSTQLCNSSCVY--SGALT------PRMLCAGYLD-GRADACQGDSGGPLVCPDGD 415
Query: 521 TWFLAGIRDFPSGCLRP 537
TW L G+ + GC P
Sbjct: 416 TWRLVGVVSWGRGCAEP 432
Score = 81.6 bits (200), Expect = 3e-15
Identities = 61/201 (30%), Positives = 92/201 (45%), Gaps = 16/201 (7%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSL--PQG 658
WPW A V + C G +LAP WV+ A HC+ + V+ G S++ QG
Sbjct: 229 WPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQG 288
Query: 659 HQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPA---GIPPGASCWVLG 715
V R +I L +ALL L + + S + +CL PA P G+ CWV G
Sbjct: 289 ALVER-IIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCL-PAKEQHFPKGSRCWVSG 346
Query: 716 WKEPQDRVPVAA------AVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCEMTSA 767
W ++ V + + ++C+ C+Y G L P LC Y +G+ + C+ S
Sbjct: 347 WGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSG 406
Query: 768 PPLLCQMTEGSWILVGMAVQG 788
PL+C + +W LVG+ G
Sbjct: 407 GPLVCPDGD-TWRLVGVVSWG 426
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 185 bits (470), Expect = 1e-46
Identities = 102/254 (40%), Positives = 134/254 (52%), Gaps = 15/254 (5%)
Query: 44 SARIVGGSNAQPGTWPWQVSLH---HGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAE 100
S RIVGG+N+ G WPWQVSL H+CGGSLI WVL+AAHCF L
Sbjct: 388 STRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF---DGLPLQDV 444
Query: 101 WSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCL 160
W + G+ + + I++ NY E D+AL++L +P + P+CL
Sbjct: 445 WRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICL 504
Query: 161 PRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTL 220
P T CW TGWG +E + +LQ+V + L+ CQ Y
Sbjct: 505 PSKGDTSTIYTNCWVTGWGFSKEKGEIQN--ILQKVNIPLVTNEECQKRYQD-------Y 555
Query: 221 QILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVA 280
+I M+CAGY EG +D C+GDSGGPLVC+ G W GITS+G GC RR +PGV+T VA
Sbjct: 556 KITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVA 615
Query: 281 TYEAWIREQVMGSE 294
Y WI E+ S+
Sbjct: 616 EYMDWILEKTQSSD 629
Score = 71.6 bits (174), Expect = 3e-12
Identities = 61/244 (25%), Positives = 100/244 (40%), Gaps = 33/244 (13%)
Query: 332 GAWPWEA--QVMVPGSRP-CHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL---- 384
G WPW+ QV + R C G+L+ WVL A CF D P D WR+
Sbjct: 400 GEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF------DGLPLQ-DVWRIYSGIL 452
Query: 385 ----LPSRPRAERVARLVQHENASWDNAS-DLALLQLRTPVNLSAASRPVCLPHPEHYFL 439
+ ++ ++ H+N + D+AL++L+ P+N + +P+CLP
Sbjct: 453 NLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTST 512
Query: 440 PGSRCRLARWGRGEPALGPGALLE---AELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496
+ C + WG + +L+ L+ C Y Q + +C
Sbjct: 513 IYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRY--QDYKI-----TQRMVCAG 565
Query: 497 YQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLR---PRAFFPLQTHGPWISHV 553
Y+E + +C DS L+C+ G W L GI + GC R P + + + WI
Sbjct: 566 YKEGGK-DACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEK 624
Query: 554 TRGA 557
T+ +
Sbjct: 625 TQSS 628
Score = 65.1 bits (157), Expect = 3e-10
Identities = 57/202 (28%), Positives = 85/202 (42%), Gaps = 18/202 (8%)
Query: 601 WPWLAEVHV---AGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQ 657
WPW + V A +C G L+ WVL A HC G +Y G S + +
Sbjct: 402 WPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF--DGLPLQDVWRIYSGILNLSDITK 459
Query: 658 G---HQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPAGIPPG--ASCW 712
Q+ ++I G +AL++L + + + PICL G +CW
Sbjct: 460 DTPFSQIKEIIIHQNYKVSEG-NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCW 518
Query: 713 VLGW---KEPQDRVPVAAAVSI--LTQRICDCLYQGI-LPPGTLCVLYAEGQENRCEMTS 766
V GW KE + + V+I +T C YQ + +C Y EG ++ C+ S
Sbjct: 519 VTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDS 578
Query: 767 APPLLCQMTEGSWILVGMAVQG 788
PL+C+ G W LVG+ G
Sbjct: 579 GGPLVCK-HNGMWRLVGITSWG 599
>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
Length = 275
Score = 185 bits (469), Expect = 2e-46
Identities = 107/251 (42%), Positives = 138/251 (54%), Gaps = 17/251 (6%)
Query: 47 IVGGSNAQPGTWPWQVSLHHGGG---HICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSV 103
IVGG A WPWQVSL G H CGGSLI P WVL+AAHC ++ A V
Sbjct: 31 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHC--VGPDVKDLAALRV 88
Query: 104 LLG---VHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCL 160
L ++ QD L V+ I+V + ++GAD+ALL L P ++ V V L
Sbjct: 89 QLREQHLYYQDQLLP------VSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTL 142
Query: 161 PRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTL 220
P AS F G CW TGWGDV + LP P+ L++V++ ++ C Y +
Sbjct: 143 PPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDV 202
Query: 221 QIL-PGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAV 279
+I+ MLCAG RRD+CQGDSGGPLVC+ G W QAG+ S+G GC + NRPG++T V
Sbjct: 203 RIVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRV 260
Query: 280 ATYEAWIREQV 290
Y WI V
Sbjct: 261 TYYLDWIHHYV 271
Score = 77.8 bits (190), Expect = 4e-14
Identities = 67/241 (27%), Positives = 102/241 (42%), Gaps = 22/241 (9%)
Query: 327 KAPRPGAWPWEAQVMVPGS---RPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV 383
+APR WPW+ + V G C G+L+ WVL A C + P+ D +
Sbjct: 36 EAPR-SKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHC-VGPDVKDLAALRVQLREQ 93
Query: 384 LLPSRPRAERVARLVQHENA-SWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGS 442
L + + V+R++ H + +D+ALL+L PVN+S+ V LP F PG
Sbjct: 94 HLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGM 153
Query: 443 RCRLARWGRGE-----PALGPGALLEAELLGGWWCHCLY---GRQGAAVPLPGDPPHALC 494
C + WG + P P ++ ++ C Y G V + D LC
Sbjct: 154 PCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRD--DMLC 211
Query: 495 PAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWIS 551
++ SC DS L+C+ GTW AG+ + GC RP + + + WI
Sbjct: 212 AGNTRRD---SCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIH 268
Query: 552 H 552
H
Sbjct: 269 H 269
Score = 73.6 bits (179), Expect = 8e-13
Identities = 63/211 (29%), Positives = 87/211 (41%), Gaps = 30/211 (14%)
Query: 601 WPWLAEVHVAGD---RVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQ 657
WPW + V G C G L+ P WVL A HCV P + + V L Q
Sbjct: 42 WPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCV-GPDVKDLAALRVQLREQHLYYQDQ 100
Query: 658 GHQVSRLVISIRLPQH--LGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGASCWV 713
VSR+++ PQ + +ALLEL V S + L PA PPG CWV
Sbjct: 101 LLPVSRIIVH---PQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWV 157
Query: 714 LGW--KEPQDRVP-----VAAAVSILTQRICDCLYQ---------GILPPGTLCVLYAEG 757
GW + +R+P V I+ ICD Y I+ LC
Sbjct: 158 TGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCA--GNT 215
Query: 758 QENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788
+ + C+ S PL+C++ G+W+ G+ G
Sbjct: 216 RRDSCQGDSGGPLVCKV-NGTWLQAGVVSWG 245
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 183 bits (465), Expect = 5e-46
Identities = 106/268 (39%), Positives = 139/268 (51%), Gaps = 19/268 (7%)
Query: 28 PTQEEPEDLDCGRPEPSA-RIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAA 86
P + E C R + RI+GG++ G WPWQVSLH G CG S+I+ W+LSAA
Sbjct: 460 PDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAA 519
Query: 87 HCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRL- 145
HCF N +P W+ LG++ Q + V IVV Y+ D+ALL+L
Sbjct: 520 HCFHGNRLSDP-TPWTAHLGMYVQG---NAKFVSPVRRIVVHEYYNSQTFDYDIALLQLS 575
Query: 146 -ASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEA 204
A P +L + P+C+P R G CW TGWG EAD VLQ+ E+ L+ +
Sbjct: 576 IAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKG-SLVLQQAEVELIDQT 634
Query: 205 TCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVC--EEGGRWFQAGITS 262
C Y I MLCAG G+RD C+GDSGGPL C + G+W GI S
Sbjct: 635 LCVSTYG---------IITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVS 685
Query: 263 FGFGCGRRNRPGVFTAVATYEAWIREQV 290
+G G GR N PGV+T V+ + WI + V
Sbjct: 686 WGHGSGRPNFPGVYTRVSNFVPWIHKYV 713
Score = 81.6 bits (200), Expect = 3e-15
Identities = 70/260 (26%), Positives = 100/260 (38%), Gaps = 29/260 (11%)
Query: 310 PQEPREENCTIALPEC-------GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPA 362
P EE CT + G G WPW+ + GS C +++S W+L+ A
Sbjct: 460 PDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAA 519
Query: 363 SCFLDPNSSDSPPRDLDAWRVLLPSRPRAERVARLVQHENASWDNAS-DLALLQLRT--P 419
CF SD P + + V R+V HE + D+ALLQL P
Sbjct: 520 HCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWP 579
Query: 420 VNLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPALGPGALL----EAELLGGWWCHCL 475
L +P+C+P G +C + WGR A G+L+ E EL+ C
Sbjct: 580 ETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST 639
Query: 476 YGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLC--QEEGTWFLAGIRDFPSG 533
YG + + LC + +C DS L C + +G W L GI + G
Sbjct: 640 YGIITSRM---------LCAGIMSGKR-DACKGDSGGPLSCRRKSDGKWILTGIVSWGHG 689
Query: 534 CLRPR---AFFPLQTHGPWI 550
RP + + PWI
Sbjct: 690 SGRPNFPGVYTRVSNFVPWI 709
Score = 75.1 bits (183), Expect = 3e-13
Identities = 63/234 (26%), Positives = 93/234 (39%), Gaps = 20/234 (8%)
Query: 569 PDGEETETQTCPPHTEHGACGLRLEAAPVGVL---WPWLAEVHVAGDRVCTGILLAPGWV 625
PDG + E TC + L L WPW +H G C +++ W+
Sbjct: 460 PDGSDEEGCTC----SRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWL 515
Query: 626 LAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLRPPLALLEL 685
L+A HC + +LG + V R+V+ +ALL+L
Sbjct: 516 LSAAHCFHGNRLSDPTPWTAHLGMYVQGNAKFVSPVRRIVVH-EYYNSQTFDYDIALLQL 574
Query: 686 SSRVEPSPSAL--PICLHPAG--IPPGASCWVLGWKEPQDR------VPVAAAVSILTQR 735
S + L PIC+ P G + G CWV GW + V A V ++ Q
Sbjct: 575 SIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQT 634
Query: 736 ICDCLYQGILPPGTLCVLYAEGQENRCEMTSAPPLLC-QMTEGSWILVGMAVQG 788
+C Y GI+ LC G+ + C+ S PL C + ++G WIL G+ G
Sbjct: 635 LCVSTY-GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWG 687
>gi|239753545 PREDICTED: similar to hCG2041452 [Homo sapiens]
Length = 410
Score = 182 bits (463), Expect = 9e-46
Identities = 101/242 (41%), Positives = 132/242 (54%), Gaps = 9/242 (3%)
Query: 45 ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVL 104
+R++GG A WPWQVSL H CGGSLI WVL+AAHC E W +L
Sbjct: 161 SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWE-GGRW-LL 218
Query: 105 LGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRAS 164
G+ G D A + + I+ P+N+ L +D+AL LA + + P CLP
Sbjct: 219 AGI----GRWDQAW-KHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKL 273
Query: 165 HRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILP 224
GT CW TGWG V E+ P+P VLQE EL ++ C C + + + +
Sbjct: 274 FEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKC-CEMLKNKNISKSKMVTR 332
Query: 225 GMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEA 284
G +C GY + +D CQGDSGGPLVCE G W Q GI S+G GCGR+ PGV+T V+ Y+
Sbjct: 333 GTVC-GYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKK 391
Query: 285 WI 286
WI
Sbjct: 392 WI 393
Score = 62.4 bits (150), Expect = 2e-09
Identities = 68/263 (25%), Positives = 104/263 (39%), Gaps = 32/263 (12%)
Query: 545 THGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEAAPVGVLWPWL 604
T GP S VT + + + L D D +Q C GL AP WPW
Sbjct: 122 TAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMIGGL---PAP-NKKWPWQ 177
Query: 605 AEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRL 664
+ + C G L+ WVL A HCV R GR + + + Q +
Sbjct: 178 VSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEG-------GRWLLAGIGRWDQAWKH 230
Query: 665 VISIRLPQHLG---LRPPLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGWKEP 719
+ I P + L +AL L+ V S P CL + G CWV GW +
Sbjct: 231 LEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGWGQV 290
Query: 720 QDRV----PVAAAVSILT----QRICDCL------YQGILPPGTLCVLYAEGQENRCEMT 765
+ V P+ + L ++ C+ L ++ GT+C +G++ C+
Sbjct: 291 SESVSGPMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVCGYNDQGKD-ACQGD 349
Query: 766 SAPPLLCQMTEGSWILVGMAVQG 788
S PL+C++ G+W+ VG+ G
Sbjct: 350 SGGPLVCEL-NGTWVQVGIVSWG 371
Score = 60.8 bits (146), Expect = 5e-09
Identities = 63/250 (25%), Positives = 99/250 (39%), Gaps = 21/250 (8%)
Query: 326 GKAPRPGA-WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL 384
G P P WPW+ + C G+L+ WVL A C + R L
Sbjct: 165 GGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCG-------WEGGRWL 217
Query: 385 LPSRPRAERVARLVQH--ENASWDNA---SDLALLQLRTPVNLSAASRPVCLPHPEHYFL 439
L R ++ + ++ +++D A SD+AL L VN S+ +P CLP
Sbjct: 218 LAGIGRWDQAWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVE 277
Query: 440 PGSRCRLARWGR-GEPALGPGALL--EAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496
G+ C + WG+ E GP L+ E EL C + +
Sbjct: 278 AGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVCG 337
Query: 497 YQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLR---PRAFFPLQTHGPW-ISH 552
Y ++ + +C DS L+C+ GTW GI + GC R P + + + W I H
Sbjct: 338 YNDQGK-DACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWIIDH 396
Query: 553 VTRGAYLEDQ 562
+ + + L +
Sbjct: 397 LRQASCLNSK 406
>gi|239748117 PREDICTED: hypothetical protein XP_002346556 [Homo
sapiens]
Length = 410
Score = 182 bits (463), Expect = 9e-46
Identities = 101/242 (41%), Positives = 132/242 (54%), Gaps = 9/242 (3%)
Query: 45 ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVL 104
+R++GG A WPWQVSL H CGGSLI WVL+AAHC E W +L
Sbjct: 161 SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWE-GGRW-LL 218
Query: 105 LGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRAS 164
G+ G D A + + I+ P+N+ L +D+AL LA + + P CLP
Sbjct: 219 AGI----GRWDQAW-KHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKL 273
Query: 165 HRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILP 224
GT CW TGWG V E+ P+P VLQE EL ++ C C + + + +
Sbjct: 274 FEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKC-CEMLKNKNISKSKMVTR 332
Query: 225 GMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEA 284
G +C GY + +D CQGDSGGPLVCE G W Q GI S+G GCGR+ PGV+T V+ Y+
Sbjct: 333 GTVC-GYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKK 391
Query: 285 WI 286
WI
Sbjct: 392 WI 393
Score = 62.4 bits (150), Expect = 2e-09
Identities = 68/263 (25%), Positives = 104/263 (39%), Gaps = 32/263 (12%)
Query: 545 THGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEAAPVGVLWPWL 604
T GP S VT + + + L D D +Q C GL AP WPW
Sbjct: 122 TAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMIGGL---PAP-NKKWPWQ 177
Query: 605 AEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRL 664
+ + C G L+ WVL A HCV R GR + + + Q +
Sbjct: 178 VSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEG-------GRWLLAGIGRWDQAWKH 230
Query: 665 VISIRLPQHLG---LRPPLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGWKEP 719
+ I P + L +AL L+ V S P CL + G CWV GW +
Sbjct: 231 LEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGWGQV 290
Query: 720 QDRV----PVAAAVSILT----QRICDCL------YQGILPPGTLCVLYAEGQENRCEMT 765
+ V P+ + L ++ C+ L ++ GT+C +G++ C+
Sbjct: 291 SESVSGPMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVCGYNDQGKD-ACQGD 349
Query: 766 SAPPLLCQMTEGSWILVGMAVQG 788
S PL+C++ G+W+ VG+ G
Sbjct: 350 SGGPLVCEL-NGTWVQVGIVSWG 371
Score = 60.8 bits (146), Expect = 5e-09
Identities = 63/250 (25%), Positives = 99/250 (39%), Gaps = 21/250 (8%)
Query: 326 GKAPRPGA-WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL 384
G P P WPW+ + C G+L+ WVL A C + R L
Sbjct: 165 GGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCG-------WEGGRWL 217
Query: 385 LPSRPRAERVARLVQH--ENASWDNA---SDLALLQLRTPVNLSAASRPVCLPHPEHYFL 439
L R ++ + ++ +++D A SD+AL L VN S+ +P CLP
Sbjct: 218 LAGIGRWDQAWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVE 277
Query: 440 PGSRCRLARWGR-GEPALGPGALL--EAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496
G+ C + WG+ E GP L+ E EL C + +
Sbjct: 278 AGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVCG 337
Query: 497 YQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLR---PRAFFPLQTHGPW-ISH 552
Y ++ + +C DS L+C+ GTW GI + GC R P + + + W I H
Sbjct: 338 YNDQGK-DACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWIIDH 396
Query: 553 VTRGAYLEDQ 562
+ + + L +
Sbjct: 397 LRQASCLNSK 406
>gi|239742016 PREDICTED: hypothetical protein XP_002342392 [Homo
sapiens]
Length = 410
Score = 182 bits (463), Expect = 9e-46
Identities = 101/242 (41%), Positives = 132/242 (54%), Gaps = 9/242 (3%)
Query: 45 ARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVL 104
+R++GG A WPWQVSL H CGGSLI WVL+AAHC E W +L
Sbjct: 161 SRMIGGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWE-GGRW-LL 218
Query: 105 LGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRAS 164
G+ G D A + + I+ P+N+ L +D+AL LA + + P CLP
Sbjct: 219 AGI----GRWDQAW-KHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKL 273
Query: 165 HRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILP 224
GT CW TGWG V E+ P+P VLQE EL ++ C C + + + +
Sbjct: 274 FEVEAGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKC-CEMLKNKNISKSKMVTR 332
Query: 225 GMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEA 284
G +C GY + +D CQGDSGGPLVCE G W Q GI S+G GCGR+ PGV+T V+ Y+
Sbjct: 333 GTVC-GYNDQGKDACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKK 391
Query: 285 WI 286
WI
Sbjct: 392 WI 393
Score = 62.4 bits (150), Expect = 2e-09
Identities = 68/263 (25%), Positives = 104/263 (39%), Gaps = 32/263 (12%)
Query: 545 THGPWISHVTRGAYLEDQLAWDWGPDGEETETQTCPPHTEHGACGLRLEAAPVGVLWPWL 604
T GP S VT + + + L D D +Q C GL AP WPW
Sbjct: 122 TAGPPGSWVTSASTVGEALESDGISDLGRQFSQACGHRVSRMIGGL---PAP-NKKWPWQ 177
Query: 605 AEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQVSRL 664
+ + C G L+ WVL A HCV R GR + + + Q +
Sbjct: 178 VSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCGWEG-------GRWLLAGIGRWDQAWKH 230
Query: 665 VISIRLPQHLG---LRPPLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGWKEP 719
+ I P + L +AL L+ V S P CL + G CWV GW +
Sbjct: 231 LEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVEAGTECWVTGWGQV 290
Query: 720 QDRV----PVAAAVSILT----QRICDCL------YQGILPPGTLCVLYAEGQENRCEMT 765
+ V P+ + L ++ C+ L ++ GT+C +G++ C+
Sbjct: 291 SESVSGPMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVCGYNDQGKD-ACQGD 349
Query: 766 SAPPLLCQMTEGSWILVGMAVQG 788
S PL+C++ G+W+ VG+ G
Sbjct: 350 SGGPLVCEL-NGTWVQVGIVSWG 371
Score = 60.8 bits (146), Expect = 5e-09
Identities = 63/250 (25%), Positives = 99/250 (39%), Gaps = 21/250 (8%)
Query: 326 GKAPRPGA-WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL 384
G P P WPW+ + C G+L+ WVL A C + R L
Sbjct: 165 GGLPAPNKKWPWQVSLQTSNIHHCGGSLIDRRWVLTAAHCVFRGCG-------WEGGRWL 217
Query: 385 LPSRPRAERVARLVQH--ENASWDNA---SDLALLQLRTPVNLSAASRPVCLPHPEHYFL 439
L R ++ + ++ +++D A SD+AL L VN S+ +P CLP
Sbjct: 218 LAGIGRWDQAWKHLEDIIFPSNFDFATLTSDIALALLAYSVNYSSHIQPACLPEKLFEVE 277
Query: 440 PGSRCRLARWGR-GEPALGPGALL--EAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPA 496
G+ C + WG+ E GP L+ E EL C + +
Sbjct: 278 AGTECWVTGWGQVSESVSGPMPLVLQETELNIMRHEKCCEMLKNKNISKSKMVTRGTVCG 337
Query: 497 YQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLR---PRAFFPLQTHGPW-ISH 552
Y ++ + +C DS L+C+ GTW GI + GC R P + + + W I H
Sbjct: 338 YNDQGK-DACQGDSGGPLVCELNGTWVQVGIVSWGIGCGRKGYPGVYTEVSFYKKWIIDH 396
Query: 553 VTRGAYLEDQ 562
+ + + L +
Sbjct: 397 LRQASCLNSK 406
>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
Length = 275
Score = 182 bits (462), Expect = 1e-45
Identities = 106/251 (42%), Positives = 137/251 (54%), Gaps = 17/251 (6%)
Query: 47 IVGGSNAQPGTWPWQVSLHHGGG---HICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSV 103
IVGG A WPWQVSL H CGGSLI P WVL+AAHC ++ A V
Sbjct: 31 IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHC--VGPDVKDLAALRV 88
Query: 104 LLG---VHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCL 160
L ++ QD L V+ I+V + ++GAD+ALL L P ++ V V L
Sbjct: 89 QLREQHLYYQDQLLP------VSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTL 142
Query: 161 PRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTL 220
P AS F G CW TGWGDV + LP P+ L++V++ ++ C Y +
Sbjct: 143 PPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDV 202
Query: 221 QIL-PGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAV 279
+I+ MLCAG RRD+CQGDSGGPLVC+ G W QAG+ S+G GC + NRPG++T V
Sbjct: 203 RIVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRV 260
Query: 280 ATYEAWIREQV 290
Y WI V
Sbjct: 261 TYYLDWIHHYV 271
Score = 75.1 bits (183), Expect = 3e-13
Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 22/241 (9%)
Query: 327 KAPRPGAWPWEAQVMVPGS---RPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV 383
+APR WPW+ + V C G+L+ WVL A C + P+ D +
Sbjct: 36 EAPR-SKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHC-VGPDVKDLAALRVQLREQ 93
Query: 384 LLPSRPRAERVARLVQHENA-SWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGS 442
L + + V+R++ H + +D+ALL+L PVN+S+ V LP F PG
Sbjct: 94 HLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGM 153
Query: 443 RCRLARWGRGE-----PALGPGALLEAELLGGWWCHCLY---GRQGAAVPLPGDPPHALC 494
C + WG + P P ++ ++ C Y G V + D LC
Sbjct: 154 PCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRD--DMLC 211
Query: 495 PAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWIS 551
++ SC DS L+C+ GTW AG+ + GC RP + + + WI
Sbjct: 212 AGNTRRD---SCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIH 268
Query: 552 H 552
H
Sbjct: 269 H 269
Score = 71.2 bits (173), Expect = 4e-12
Identities = 64/212 (30%), Positives = 88/212 (41%), Gaps = 32/212 (15%)
Query: 601 WPWLAEVHVAGDRV----CTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLP 656
WPW + V DR C G L+ P WVL A HCV P + + V L
Sbjct: 42 WPWQVSLRVR-DRYWMHFCGGSLIHPQWVLTAAHCV-GPDVKDLAALRVQLREQHLYYQD 99
Query: 657 QGHQVSRLVISIRLPQH--LGLRPPLALLELSSRVEPSPSALPICLHPAG--IPPGASCW 712
Q VSR+++ PQ + +ALLEL V S + L PA PPG CW
Sbjct: 100 QLLPVSRIIVH---PQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCW 156
Query: 713 VLGW--KEPQDRVP-----VAAAVSILTQRICDCLYQ---------GILPPGTLCVLYAE 756
V GW + +R+P V I+ ICD Y I+ LC
Sbjct: 157 VTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCA--GN 214
Query: 757 GQENRCEMTSAPPLLCQMTEGSWILVGMAVQG 788
+ + C+ S PL+C++ G+W+ G+ G
Sbjct: 215 TRRDSCQGDSGGPLVCKV-NGTWLQAGVVSWG 245
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 181 bits (459), Expect = 3e-45
Identities = 106/261 (40%), Positives = 144/261 (55%), Gaps = 22/261 (8%)
Query: 37 DCGRPEPSAR----IVGGSNAQPGTWPWQVSLH-HGGGHICGGSLIAPSWVLSAAHCFMT 91
DCGR P+AR I+GG ++PG WPWQ SL GHICG LIA WVL+ AHCF
Sbjct: 789 DCGR-RPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEG 847
Query: 92 NGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASL 151
E AA W V+LG+++ D P TR V I++ YS+ + D++++ L+ S
Sbjct: 848 R---ENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISE 904
Query: 152 GPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYS 211
V PVCLP T C+ TGWG + +P+ LQE E+R++ CQ +
Sbjct: 905 TGYVRPVCLPNPEQWLEPDTYCYITGWGHMGN----KMPFKLQEGEVRIISLEHCQSYFD 960
Query: 212 QPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEE-GGRWFQAGITSFGFGC-GR 269
I M+CAGY G D+C GDSGGPLVCE+ GGRW G+TS+G C +
Sbjct: 961 MK-------TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSK 1013
Query: 270 RNRPGVFTAVATYEAWIREQV 290
PGV++ V+ + WI+ Q+
Sbjct: 1014 VLGPGVYSNVSYFVEWIKRQI 1034
Score = 75.1 bits (183), Expect = 3e-13
Identities = 61/220 (27%), Positives = 95/220 (43%), Gaps = 25/220 (11%)
Query: 326 GKAPRPGAWPWEAQVMV-PGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL 384
G+ RPG WPW+ + P C L+++ WVL A CF ++ W+V+
Sbjct: 805 GRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAA-------VWKVV 857
Query: 385 L-------PSRPRAER-VARLVQHENASWDNAS-DLALLQLRTPVNLSAASRPVCLPHPE 435
L PS R V ++ H S D+++++L ++ + RPVCLP+PE
Sbjct: 858 LGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPE 917
Query: 436 HYFLPGSRCRLARWGRGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCP 495
+ P + C + WG + P L E E+ HC + + +C
Sbjct: 918 QWLEPDTYCYITGWGHMGNKM-PFKLQEGEVRIISLEHC-----QSYFDMKTITTRMICA 971
Query: 496 AYQEKEEVGSCWNDSRWSLLCQEE-GTWFLAGIRDFPSGC 534
Y E V SC DS L+C++ G W L G+ + S C
Sbjct: 972 GY-ESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVC 1010
Score = 62.4 bits (150), Expect = 2e-09
Identities = 50/208 (24%), Positives = 81/208 (38%), Gaps = 13/208 (6%)
Query: 601 WPWLAEVHVA-GDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGH 659
WPW + +C +L+A WVL HC G +V LG P
Sbjct: 813 WPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCF--EGRENAAVWKVVLGINNLDH-PSVF 869
Query: 660 QVSRLVISIRLPQHLG---LRPPLALLELSSRVEPSPSALPICLH--PAGIPPGASCWVL 714
+R V +I L + ++++ELS + + P+CL + P C++
Sbjct: 870 MQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYIT 929
Query: 715 GWKEPQDRVPVA---AAVSILTQRICDCLYQ-GILPPGTLCVLYAEGQENRCEMTSAPPL 770
GW +++P V I++ C + + +C Y G + C S PL
Sbjct: 930 GWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPL 989
Query: 771 LCQMTEGSWILVGMAVQGSRELFAAIGP 798
+C+ G W L G+ GS +GP
Sbjct: 990 VCEKPGGRWTLFGLTSWGSVCFSKVLGP 1017
>gi|148806900 epidermis-specific serine protease-like protein [Homo
sapiens]
Length = 328
Score = 180 bits (456), Expect = 6e-45
Identities = 97/255 (38%), Positives = 137/255 (53%), Gaps = 9/255 (3%)
Query: 38 CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97
CG+P S+R+VGG +A G WPWQVSLH ICGGSL++ +L+AAHC T
Sbjct: 19 CGQPVYSSRVVGGQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFS 78
Query: 98 AAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWP 157
W + V G V+ IV+ Y + AD+ALL+L+S + A+ P
Sbjct: 79 YTVWLGSITV----GDSRKRVKYYVSKIVIHPKYQ--DTTADVALLKLSSQVTFTSAILP 132
Query: 158 VCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFN 217
+CLP + + CW TGWG V+E+ LQE E+ ++ C+ LY+ G F
Sbjct: 133 ICLPSVTKQLAIPPFCWVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFL 192
Query: 218 LTLQ--ILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGV 275
L+ I +CAG + +D+C+GDSGGPL C G W Q G+ S+G CG ++ PGV
Sbjct: 193 PALEPVIKEDKICAGDTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLECG-KSLPGV 251
Query: 276 FTAVATYEAWIREQV 290
+T V Y+ WI +
Sbjct: 252 YTNVIYYQKWINATI 266
Score = 87.0 bits (214), Expect = 7e-17
Identities = 75/242 (30%), Positives = 112/242 (46%), Gaps = 37/242 (15%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLG--RAGASSLPQG 658
WPW +H + +C G L++ +L A HC+ +P TT Y V+LG G S
Sbjct: 39 WPWQVSLHFDHNFICGGSLVSERLILTAAHCI-QPTWTTFSY-TVWLGSITVGDSRKRVK 96
Query: 659 HQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICL----HPAGIPPGASCWVL 714
+ VS++VI P++ +ALL+LSS+V + + LPICL IPP CWV
Sbjct: 97 YYVSKIVIH---PKYQDTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPP--FCWVT 151
Query: 715 GW---KEPQDR----VPVAAAVSILTQRICDCLYQ--GILPPG--------TLCVLYAEG 757
GW KE DR A V I+ ++ C+ LY GI P +C +
Sbjct: 152 GWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKICAGDTQN 211
Query: 758 QENRCEMTSAPPLLCQMTEGSWILVGMAVQGSR------ELFAAIGPEEAWISQTVGEAN 811
++ C+ S PL C + +G WI G+ G ++ + + WI+ T+ AN
Sbjct: 212 MKDSCKGDSGGPLSCHI-DGVWIQTGVVSWGLECGKSLPGVYTNVIYYQKWINATISRAN 270
Query: 812 FL 813
L
Sbjct: 271 NL 272
Score = 64.3 bits (155), Expect = 5e-10
Identities = 61/217 (28%), Positives = 93/217 (42%), Gaps = 11/217 (5%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G+ G WPW+ + + C G+LVSE +L A C ++ S L + V
Sbjct: 31 GQDAAAGRWPWQVSLHFDHNFICGGSLVSERLILTAAHCIQPTWTTFSYTVWLGSITV-G 89
Query: 386 PSRPRAE-RVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRC 444
SR R + V+++V H D +D+ALL+L + V ++A P+CLP C
Sbjct: 90 DSRKRVKYYVSKIVIHPKYQ-DTTADVALLKLSSQVTFTSAILPICLPSVTKQLAIPPFC 148
Query: 445 RLARWGRGEPALG---PGALLEAE--LLGGWWCHCLYGRQGAAVPL--PGDPPHALCPAY 497
+ WG+ + + AL EAE ++ C LY G +P P +C A
Sbjct: 149 WVTGWGKVKESSDRDYHSALQEAEVPIIDRQACEQLYNPIGIFLPALEPVIKEDKIC-AG 207
Query: 498 QEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC 534
+ SC DS L C +G W G+ + C
Sbjct: 208 DTQNMKDSCKGDSGGPLSCHIDGVWIQTGVVSWGLEC 244
>gi|21614533 testisin isoform 3 [Homo sapiens]
Length = 300
Score = 178 bits (451), Expect = 2e-44
Identities = 98/281 (34%), Positives = 149/281 (53%), Gaps = 25/281 (8%)
Query: 28 PTQEEPEDLD--CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSA 85
P +E L CGR ++RIVGG +A+ G WPWQ SL H+CG SL++ W L+A
Sbjct: 21 PESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTA 80
Query: 86 AHCFMTNGTLEPAAEWSVLLGVHS---QDGPLDGAHTRAVAAIVVPANYSQVELGADLAL 142
AHCF T L + W V G + L +TR + + + D+AL
Sbjct: 81 AHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIAL 140
Query: 143 LRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLG 202
++L++P + + P+CL ++ F + T CW TGWG ++E + LP P LQEV++ ++
Sbjct: 141 VKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIIN 200
Query: 203 EATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITS 262
+ C L+ + ++ I M GDSGGPL C + G W+Q G+ S
Sbjct: 201 NSMCNHLFLK---YSFRKDIFGDM--------------GDSGGPLACNKNGLWYQIGVVS 243
Query: 263 FGFGCGRRNRPGVFTAVATYEAWIRE---QVMGSEPGPAFP 300
+G GCGR NRPGV+T ++ + WI++ Q S+P P++P
Sbjct: 244 WGVGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQPDPSWP 284
Score = 60.5 bits (145), Expect = 7e-09
Identities = 56/245 (22%), Positives = 91/245 (37%), Gaps = 42/245 (17%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV-- 383
G+ G WPW+ + + S C +L+S W L A CF + S D W V
Sbjct: 45 GEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCF----ETYSDLSDPSGWMVQF 100
Query: 384 -LLPSRP---------RAERVARLVQHENASWDNASDLALLQLRTPVNLSAASRPVCLPH 433
L S P V+ + ++ D+AL++L PV + +P+CL
Sbjct: 101 GQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHIQPICLQA 160
Query: 434 PEHYFLPGSRCRLARWG---RGEPALGPGALLEAE--LLGGWWCHCLYGRQGAAVPLPGD 488
F + C + WG E P L E + ++ C+ L+ +
Sbjct: 161 STFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK---------- 210
Query: 489 PPHALCPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCLRPR---AFFPLQT 545
Y ++++ DS L C + G W+ G+ + GC RP + +
Sbjct: 211 --------YSFRKDIFGDMGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISH 262
Query: 546 HGPWI 550
H WI
Sbjct: 263 HFEWI 267
Score = 56.2 bits (134), Expect = 1e-07
Identities = 73/281 (25%), Positives = 112/281 (39%), Gaps = 51/281 (18%)
Query: 575 ETQTCPPHTEHGACGLRL--------EAAPVGVLWPWLAEVHVAGDRVCTGILLAPGWVL 626
E+Q P + G CG R+ E A +G WPW + + VC LL+ W L
Sbjct: 22 ESQEAAPLS--GPCGRRVITSRIVGGEDAELG-RWPWQGSLRLWDSHVCGVSLLSHRWAL 78
Query: 627 AATHCVLRPGSTTVPY-IEVYLGRAGASSLP-----QGHQVSRLVISIRL-PQHLGLRP- 678
A HC + P V G+ +S+P Q + V +I L P++LG P
Sbjct: 79 TAAHCFETYSDLSDPSGWMVQFGQ--LTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPY 136
Query: 679 PLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGW---KE----PQDRVPVAAAV 729
+AL++LS+ V + PICL + CWV GW KE P V
Sbjct: 137 DIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQV 196
Query: 730 SILTQRICDCLYQGILPPGTLCVLYAEGQENRCEM-TSAPPLLCQMTEGSWILVGMAVQG 788
+I+ +C+ L+ + Y+ ++ +M S PL C G W +G+ G
Sbjct: 197 AIINNSMCNHLF----------LKYSFRKDIFGDMGDSGGPLACN-KNGLWYQIGVVSWG 245
Query: 789 -------SRELFAAIGPEEAWISQTVGEANFLPPSGSPHWP 822
++ I WI + + ++ P P WP
Sbjct: 246 VGCGRPNRPGVYTNISHHFEWIQKLMAQSGMSQP--DPSWP 284
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 174 bits (441), Expect = 3e-43
Identities = 99/245 (40%), Positives = 134/245 (54%), Gaps = 16/245 (6%)
Query: 46 RIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLL 105
RI+GG+ A+ G+WPWQVSL H CGGSLI W+L+AAHCF +N +W
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSN---PRDWIATS 242
Query: 106 GVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASH 165
G+ + L V I++ NY D+AL+RL + + + VCLP A+
Sbjct: 243 GISTTFPKL----RMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ 298
Query: 166 RFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPG 225
G+ + TGWG QE +P L++ ++R++ C +S G IL G
Sbjct: 299 NIPPGSTAYVTGWG-AQEYAGHTVP-ELRQGQVRIISNDVCNAPHSYNG------AILSG 350
Query: 226 MLCAGYPEGRRDTCQGDSGGPLVCEEGGR-WFQAGITSFGFGCGRRNRPGVFTAVATYEA 284
MLCAG P+G D CQGDSGGPLV E+ R WF GI S+G CG ++PGV+T V Y
Sbjct: 351 MLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLD 410
Query: 285 WIREQ 289
WIR+Q
Sbjct: 411 WIRQQ 415
Score = 73.9 bits (180), Expect = 6e-13
Identities = 63/241 (26%), Positives = 102/241 (42%), Gaps = 26/241 (10%)
Query: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385
G G+WPW+ + + + C G+L++ W+L A CF S+S PRD A +
Sbjct: 190 GTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCF----RSNSNPRDWIATSGIS 245
Query: 386 PSRPRAE-RVARLVQHEN-ASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSR 443
+ P+ RV ++ H N S + +D+AL++L V + VCLP PGS
Sbjct: 246 TTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGST 305
Query: 444 CRLARWGRGE------PALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAY 497
+ WG E P L G + ++ C+ + GA + LC A
Sbjct: 306 AYVTGWGAQEYAGHTVPELRQG---QVRIISNDVCNAPHSYNGAIL------SGMLC-AG 355
Query: 498 QEKEEVGSCWNDSRWSLLCQE-EGTWFLAGIRDFPSGC---LRPRAFFPLQTHGPWISHV 553
+ V +C DS L+ ++ WF+ GI + C +P + + + WI
Sbjct: 356 VPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQ 415
Query: 554 T 554
T
Sbjct: 416 T 416
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/199 (24%), Positives = 84/199 (42%), Gaps = 13/199 (6%)
Query: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660
WPW + + C G L+ W+L A HC R S +I +++ P+
Sbjct: 198 WPWQVSLRLNNAHHCGGSLINNMWILTAAHC-FRSNSNPRDWIAT---SGISTTFPKLRM 253
Query: 661 VSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPA--GIPPGASCWVLGWKE 718
R ++ + +AL+ L + V + +CL A IPPG++ +V GW
Sbjct: 254 RVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGA 313
Query: 719 PQ---DRVPV--AAAVSILTQRICDC--LYQGILPPGTLCVLYAEGQENRCEMTSAPPLL 771
+ VP V I++ +C+ Y G + G LC +G + C+ S PL+
Sbjct: 314 QEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLV 373
Query: 772 CQMTEGSWILVGMAVQGSR 790
+ + W +VG+ G +
Sbjct: 374 QEDSRRLWFIVGIVSWGDQ 392
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.466
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,895,966
Number of Sequences: 37866
Number of extensions: 2529547
Number of successful extensions: 7832
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 6380
Number of HSP's gapped (non-prelim): 644
length of query: 855
length of database: 18,247,518
effective HSP length: 111
effective length of query: 744
effective length of database: 14,044,392
effective search space: 10449027648
effective search space used: 10449027648
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.