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Search of human proteins with 57165371
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57165371 G protein-coupled receptor 61 [Homo sapiens]
(451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57165371 G protein-coupled receptor 61 [Homo sapiens] 897 0.0
gi|145309315 G protein-coupled receptor 62 [Homo sapiens] 155 5e-38
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 124 1e-28
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 124 2e-28
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 124 2e-28
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 117 2e-26
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 114 1e-25
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 108 1e-23
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 106 4e-23
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 106 4e-23
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 106 4e-23
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 106 4e-23
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 106 4e-23
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 106 4e-23
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 104 2e-22
gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens] 103 2e-22
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 102 5e-22
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 102 5e-22
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 102 5e-22
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 102 5e-22
gi|15150803 opsin 4 isoform 1 [Homo sapiens] 102 5e-22
gi|149944554 somatostatin receptor 4 [Homo sapiens] 97 4e-20
gi|71999143 opsin 4 isoform 2 [Homo sapiens] 96 5e-20
gi|4503383 dopamine receptor D1 [Homo sapiens] 96 5e-20
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 94 3e-19
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 94 3e-19
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 94 3e-19
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 90 4e-18
gi|4557865 somatostatin receptor 5 [Homo sapiens] 87 2e-17
gi|28875799 cholecystokinin B receptor [Homo sapiens] 86 7e-17
>gi|57165371 G protein-coupled receptor 61 [Homo sapiens]
Length = 451
Score = 897 bits (2318), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN 60
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN
Sbjct: 1 MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN 60
Query: 61 AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF 120
AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF
Sbjct: 61 AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF 120
Query: 121 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG 180
LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG
Sbjct: 121 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG 180
Query: 181 RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM 240
RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM
Sbjct: 181 RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM 240
Query: 241 QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW 300
QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW
Sbjct: 241 QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW 300
Query: 301 LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF 360
LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF
Sbjct: 301 LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF 360
Query: 361 KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE 420
KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE
Sbjct: 361 KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE 420
Query: 421 ETSEFLEQQLTSDIIMSDSYLRPAASPRLES 451
ETSEFLEQQLTSDIIMSDSYLRPAASPRLES
Sbjct: 421 ETSEFLEQQLTSDIIMSDSYLRPAASPRLES 451
>gi|145309315 G protein-coupled receptor 62 [Homo sapiens]
Length = 368
Score = 155 bits (393), Expect = 5e-38
Identities = 123/377 (32%), Positives = 180/377 (47%), Gaps = 38/377 (10%)
Query: 43 SVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSS 102
S+ L ++++ A+ GN A++ V+ +TP LR +++ HLC+VDLLAA ++MPL +L++
Sbjct: 15 SLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAP 74
Query: 103 AL-FDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVAS 161
G CR FLS + L V+A+ + RY +VHP+R R L
Sbjct: 75 PPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVL--- 131
Query: 162 VLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPL 221
VL VW A + ++ +LG P P CS+ + F ++A+L F LP
Sbjct: 132 VLTAVWAAAGLLGALSLLGT---PPAPPPAPARCSVL---AGGLGPFRPLWALLAFALPA 185
Query: 222 LLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFG 281
LL+L Y +F VAR AA++ P R S+SL SR +++ P P
Sbjct: 186 LLLLGAYGGIFVVARRAALRP---PRPARGSRLHSDSLDSRLSIL-----PPLRPR--LP 235
Query: 282 GGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFY 341
GGKAA+ GQF CWLPY A A + E+ VTW+ Y F ++PF Y
Sbjct: 236 GGKAALAPALAVGQFAACWLPY-----GCACLAPAARAAEAEAAVTWVAYSAFAAHPFLY 290
Query: 342 GCLNRQIR---GELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSR 398
G L R +R G LS++ + P P +R + + LQ LQ P E
Sbjct: 291 GLLQRPVRLALGRLSRRAL----PGP---VRACTPQAWHPRALLQCLQR---PPEGPAVG 340
Query: 399 PLPSPKQEPPAVDFRIP 415
P +P+Q P R P
Sbjct: 341 PSEAPEQTPELAGGRSP 357
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 124 bits (312), Expect = 1e-28
Identities = 111/352 (31%), Positives = 171/352 (48%), Gaps = 28/352 (7%)
Query: 19 VPQTPGPSTASGVPEVGLRDVASES----VALFFMLLLDLTAVAGNAAVMAVIAKTPALR 74
VP+ PGP TA+ P G ++ VA +++ LTA A N+ ++A+I PALR
Sbjct: 2 VPE-PGP-TANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAA-NSLLIALICTQPALR 58
Query: 75 KF--VFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILS 132
F+ L DL+ L +MP AML+ AL+ + C L+ V S +IL+
Sbjct: 59 NTSNFFLVSLFTSDLMVGLVVMPPAMLN--ALYGRWVLARGLCLLWTAFDVMCCSASILN 116
Query: 133 VSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEE---GAP 189
+ I+++RY ++ P+RY++RMT ++++G W A + +P+L + W E P
Sbjct: 117 LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL--LGWHELGHARP 174
Query: 190 SVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWM 249
VP C L S FV+V + L F LP I YC + AR A+Q L T M
Sbjct: 175 PVPGQCRLLASLP-----FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGM 229
Query: 250 ETPRQRSESLSSRSTM---VTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSF 306
+ Q SE+L T V S+ + + + KA++ L + G F + WLP+F
Sbjct: 230 AS--QASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVA 287
Query: 307 HLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVC 358
++ A+ IS G + V+TW+GY T NP Y R + L + C
Sbjct: 288 NIVQAV-CDCISPGLFD-VLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 124 bits (310), Expect = 2e-28
Identities = 90/315 (28%), Positives = 144/315 (45%), Gaps = 39/315 (12%)
Query: 49 MLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALFD 106
+ +L L VAGN V + LR F+ L + DLL L ++P + + L
Sbjct: 25 LAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQ--LSC 82
Query: 107 HALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGV 166
FG+V C +Y L V + +IL++ I+++RY V+ P+RY V +T VA LV +
Sbjct: 83 KWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI 142
Query: 167 WVKALAMASVPV-LGRVSWEEGAPS--VPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLL 223
WV ++ ++ + + LG S E + C +Q + +++ +V ++ F LPLL+
Sbjct: 143 WVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVN-----EVYGLVDGLVTFYLPLLI 197
Query: 224 ILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGG 283
+ + Y +F+VAR A + + +W T
Sbjct: 198 MCITYYRIFKVARDQAKRINHISSWKAA---------------------------TIREH 230
Query: 284 KAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGC 343
KA V L AV G F++CW PYF+ +Y L +E++V W+GY NP Y
Sbjct: 231 KATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAA 290
Query: 344 LNRQIRGELSKQFVC 358
LNR R + F C
Sbjct: 291 LNRDFRTGYQQLFCC 305
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 124 bits (310), Expect = 2e-28
Identities = 90/315 (28%), Positives = 144/315 (45%), Gaps = 39/315 (12%)
Query: 49 MLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALFD 106
+ +L L VAGN V + LR F+ L + DLL L ++P + + L
Sbjct: 25 LAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQ--LSC 82
Query: 107 HALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGV 166
FG+V C +Y L V + +IL++ I+++RY V+ P+RY V +T VA LV +
Sbjct: 83 KWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI 142
Query: 167 WVKALAMASVPV-LGRVSWEEGAPS--VPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLL 223
WV ++ ++ + + LG S E + C +Q + +++ +V ++ F LPLL+
Sbjct: 143 WVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVN-----EVYGLVDGLVTFYLPLLI 197
Query: 224 ILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGG 283
+ + Y +F+VAR A + + +W T
Sbjct: 198 MCITYYRIFKVARDQAKRINHISSWKAA---------------------------TIREH 230
Query: 284 KAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGC 343
KA V L AV G F++CW PYF+ +Y L +E++V W+GY NP Y
Sbjct: 231 KATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAA 290
Query: 344 LNRQIRGELSKQFVC 358
LNR R + F C
Sbjct: 291 LNRDFRTGYQQLFCC 305
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 117 bits (294), Expect = 2e-26
Identities = 98/368 (26%), Positives = 163/368 (44%), Gaps = 34/368 (9%)
Query: 12 NSSTLGRVPQTPGPSTASGVPEVGLRDVASESVAL-FFMLLLDLTAVAGNAAVMAVIAKT 70
N S+ G +G VG V+++ V + F+ L AVAGN V+ +A
Sbjct: 65 NRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACN 124
Query: 71 PALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSL 128
L+ F+ +L + DLL + T++P + ++ + FG C ++ + V +
Sbjct: 125 RHLQTVTNYFIVNLAVADLLLSATVLPFS--ATMEVLGFWAFGRAFCDVWAAVDVLCCTA 182
Query: 129 AILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGA 188
+ILS+ I+V+RY V H ++Y MT A++L +WV AL ++ P+LG W+E
Sbjct: 183 SILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLG---WKEPV 239
Query: 189 PSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTW 248
P C + + V +V F LP+ +I+V+YC ++ VAR L
Sbjct: 240 PPDERFCGITEEAG-----YAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRS---LEAG 291
Query: 249 METPRQRSESLSSR------STMVTSSGAPQTTPHRTFGGG------------KAAVVLL 290
++ R ++ + R +T + ++ TF KAA L
Sbjct: 292 VKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLA 351
Query: 291 AVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRG 350
V G F+LCW P+F +L Q + V V+ W+GYF NP Y C +R+ +
Sbjct: 352 IVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKR 411
Query: 351 ELSKQFVC 358
+ C
Sbjct: 412 AFLRLLRC 419
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 114 bits (286), Expect = 1e-25
Identities = 105/347 (30%), Positives = 160/347 (46%), Gaps = 26/347 (7%)
Query: 13 SSTLGRVPQTP--GPSTA--SGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIA 68
+S+L P P P+TA SG+P V ++A + L L V GN V+ IA
Sbjct: 8 NSSLAPWPDLPTLAPNTANTSGLPGVPWE----AALAGALLALAVLATVGGNLLVIVAIA 63
Query: 69 KTPALRKF--VFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFV 126
TP L+ VFV L DL+ L ++P A ++ AL H G C L+ + V V
Sbjct: 64 WTPRLQTMTNVFVTSLAAADLVMGLLVVPPA--ATLALTGHWPLGATGCELWTSVDVLCV 121
Query: 127 SLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEE 186
+ +I ++ A+ V+RY V +P+RY +T + +V VWV + A++ P++ + W
Sbjct: 122 TASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQ-WWRV 180
Query: 187 GAPSVPPGCSLQWSHSAYC--QLFVVVFAVLYFLLPLLLILVVYCSMFRVA----RVAAM 240
GA + C A+ +V++ + + F LPLL++L VY +F VA R+
Sbjct: 181 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 240
Query: 241 QHGPLPTWMETPRQRSESLSSR--STMVTSSGAPQ--TTPHR--TFGGGKAAVVLLAVGG 294
+ G P E+P S SL+ T G P P R +A L + G
Sbjct: 241 ELGRFPP-EESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMG 299
Query: 295 QFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFY 341
F LCWLP+F ++ AL + G + W+GY NP Y
Sbjct: 300 TFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY 346
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 108 bits (269), Expect = 1e-23
Identities = 94/377 (24%), Positives = 170/377 (45%), Gaps = 29/377 (7%)
Query: 26 STASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLC 83
S+ S +P++ + S + L +L A+ GN V+ +A LR F+ +L
Sbjct: 32 SSNSTLPQLDITRAISVGLVLGAFILF---AIVGNILVILSVACNRHLRTPTNYFIVNLA 88
Query: 84 LVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYY 143
+ DLL + T++P + ++ + + + G + C ++ + V + +ILS+ AI+++RY
Sbjct: 89 MADLLLSFTVLPFS--AALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 146
Query: 144 VVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSA 203
V + ++Y +T L+ VWV + ++ P+LG W+E AP+ C +
Sbjct: 147 VRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLG---WKEPAPNDDKECGVTE---- 199
Query: 204 YCQLFVVVFAVL-YFLLPLLLILVVYCSMFRVAR--VAAMQHGPLPTWMETPR--QRSES 258
+ F +F+ L F +PL +ILV+YC ++ VA+ ++ G + + R S
Sbjct: 200 --EPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHS 257
Query: 259 LSSRSTMVTSSGAPQTTPHRTFG--------GGKAAVVLLAVGGQFLLCWLPYFSFHLYV 310
+ ++S+ A P + KAA L V G F+LCWLP+F
Sbjct: 258 KNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLG 317
Query: 311 ALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRL 370
+L + V VV W+GYF NP Y C +++ + + C + R
Sbjct: 318 SLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRR 377
Query: 371 PSREGSIEENFLQFLQG 387
R G + + +G
Sbjct: 378 RRRLGGCAYTYRPWTRG 394
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 106 bits (265), Expect = 4e-23
Identities = 87/315 (27%), Positives = 139/315 (44%), Gaps = 24/315 (7%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFV-----VVFAV 214
A +L G WV ++ +P++ + + Q S+S YC V + +V
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSV 198
Query: 215 LYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQT 274
+ F +P LL+++ Y ++ A+ A Q L + R +S ST
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHST---------- 248
Query: 275 TPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF 334
HR KAA L + G F LCW P+F ++ + GQV + W+GY
Sbjct: 249 --HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PGQVWTAFLWLGYINS 305
Query: 335 TSNPFFYGCLNRQIR 349
NPF Y LN+ R
Sbjct: 306 GLNPFLYAFLNKSFR 320
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 106 bits (265), Expect = 4e-23
Identities = 87/315 (27%), Positives = 139/315 (44%), Gaps = 24/315 (7%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFV-----VVFAV 214
A +L G WV ++ +P++ + + Q S+S YC V + +V
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSV 198
Query: 215 LYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQT 274
+ F +P LL+++ Y ++ A+ A Q L + R +S ST
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHST---------- 248
Query: 275 TPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF 334
HR KAA L + G F LCW P+F ++ + GQV + W+GY
Sbjct: 249 --HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PGQVWTAFLWLGYINS 305
Query: 335 TSNPFFYGCLNRQIR 349
NPF Y LN+ R
Sbjct: 306 GLNPFLYAFLNKSFR 320
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 106 bits (265), Expect = 4e-23
Identities = 87/315 (27%), Positives = 139/315 (44%), Gaps = 24/315 (7%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFV-----VVFAV 214
A +L G WV ++ +P++ + + Q S+S YC V + +V
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSV 198
Query: 215 LYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQT 274
+ F +P LL+++ Y ++ A+ A Q L + R +S ST
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHST---------- 248
Query: 275 TPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF 334
HR KAA L + G F LCW P+F ++ + GQV + W+GY
Sbjct: 249 --HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PGQVWTAFLWLGYINS 305
Query: 335 TSNPFFYGCLNRQIR 349
NPF Y LN+ R
Sbjct: 306 GLNPFLYAFLNKSFR 320
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 106 bits (265), Expect = 4e-23
Identities = 87/315 (27%), Positives = 139/315 (44%), Gaps = 24/315 (7%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFV-----VVFAV 214
A +L G WV ++ +P++ + + Q S+S YC V + +V
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSV 198
Query: 215 LYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQT 274
+ F +P LL+++ Y ++ A+ A Q L + R +S ST
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHST---------- 248
Query: 275 TPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF 334
HR KAA L + G F LCW P+F ++ + GQV + W+GY
Sbjct: 249 --HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PGQVWTAFLWLGYINS 305
Query: 335 TSNPFFYGCLNRQIR 349
NPF Y LN+ R
Sbjct: 306 GLNPFLYAFLNKSFR 320
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 106 bits (265), Expect = 4e-23
Identities = 87/315 (27%), Positives = 139/315 (44%), Gaps = 24/315 (7%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFV-----VVFAV 214
A +L G WV ++ +P++ + + Q S+S YC V + +V
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSV 198
Query: 215 LYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQT 274
+ F +P LL+++ Y ++ A+ A Q L + R +S ST
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHST---------- 248
Query: 275 TPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF 334
HR KAA L + G F LCW P+F ++ + GQV + W+GY
Sbjct: 249 --HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PGQVWTAFLWLGYINS 305
Query: 335 TSNPFFYGCLNRQIR 349
NPF Y LN+ R
Sbjct: 306 GLNPFLYAFLNKSFR 320
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 106 bits (265), Expect = 4e-23
Identities = 87/315 (27%), Positives = 139/315 (44%), Gaps = 24/315 (7%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFV-----VVFAV 214
A +L G WV ++ +P++ + + Q S+S YC V + +V
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSV 198
Query: 215 LYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQT 274
+ F +P LL+++ Y ++ A+ A Q L + R +S ST
Sbjct: 199 VAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHST---------- 248
Query: 275 TPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCF 334
HR KAA L + G F LCW P+F ++ + GQV + W+GY
Sbjct: 249 --HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PGQVWTAFLWLGYINS 305
Query: 335 TSNPFFYGCLNRQIR 349
NPF Y LN+ R
Sbjct: 306 GLNPFLYAFLNKSFR 320
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 104 bits (259), Expect = 2e-22
Identities = 89/329 (27%), Positives = 142/329 (43%), Gaps = 38/329 (11%)
Query: 44 VALFFMLLLDLTAVAGNAAVMAVIAKTPALRKF---VFVFHLCLVDLLAALTLMPLAMLS 100
V L F+ + L A+ GN VM + LRK F+ L DLL ++ +MP +
Sbjct: 21 VLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIE 80
Query: 101 SSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVV-HPMRYEVRMTLGLV 159
+ D ++GEV C + L V + +I + I+++RYY + P+ Y +MT +
Sbjct: 81 --LVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRI 138
Query: 160 ASVLVGVWVKALAMASVPVL------GRVSWEEGAP--------SVPPGCSLQWSHSAYC 205
A +L G WV ++ +P++ G + E ++ Q S+S YC
Sbjct: 139 ALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYC 198
Query: 206 QLFV-----VVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLS 260
V + +V+ F +P LL+++ Y ++ A+ A Q L + R +S
Sbjct: 199 VFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSAD 258
Query: 261 SRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTG 320
ST HR KAA L + G F LCW P+F ++ + G
Sbjct: 259 QHST------------HRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTV-PG 305
Query: 321 QVESVVTWIGYFCFTSNPFFYGCLNRQIR 349
QV + W+GY NPF Y LN+ R
Sbjct: 306 QVWTAFLWLGYINSGLNPFLYAFLNKSFR 334
>gi|24476016 G protein-coupled receptor 161 isoform 2 [Homo sapiens]
Length = 529
Score = 103 bits (258), Expect = 2e-22
Identities = 83/312 (26%), Positives = 147/312 (47%), Gaps = 18/312 (5%)
Query: 49 MLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALFD 106
++++ + GN ++ + K L FVF L L + L ++ ++P + SS +
Sbjct: 34 IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSS--IRR 91
Query: 107 HALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGV 166
+FG V C L + S ++L++ I ++RYY V++PM Y +++T LV +
Sbjct: 92 EWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYI 151
Query: 167 WVKALAMASVPVLG--RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLI 224
W+ +L P+ G V ++E + ++A+ Q++ +F P L++
Sbjct: 152 WLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALF-------PFLVM 204
Query: 225 LVVYCSMFRVARVAAMQ-HGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGG 283
LV Y +FRVARV A + H +E QR+ +S ST +SSG+ +
Sbjct: 205 LVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRKNS-STSTSSSGSRRNAFQGVVYSA 263
Query: 284 ---KAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFF 340
KA + +L V G F++ W PY AL + + +E+ TW+ + +P
Sbjct: 264 NQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLI 323
Query: 341 YGCLNRQIRGEL 352
YG N+ +R EL
Sbjct: 324 YGLWNKTVRKEL 335
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 102 bits (255), Expect = 5e-22
Identities = 96/355 (27%), Positives = 152/355 (42%), Gaps = 40/355 (11%)
Query: 10 SGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAK 69
SGN+S Q P P S +G+ + L L V GN V+ +A
Sbjct: 5 SGNASDSSNCTQPPAPVNISKAILLGV-----------ILGGLILFGVLGNILVILSVA- 52
Query: 70 TPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFD---HALFGEVACRLYLFLSVCFV 126
R V H +V+L A L+ +L SA+F+ + FG V C ++ + V
Sbjct: 53 --CHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 110
Query: 127 SLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEE 186
+ +I+ + I+++RY V +P+RY +T L+ VW +L ++ P+ G W +
Sbjct: 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQ 167
Query: 187 GAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLP 246
AP C + +V+ A+ F LPL +ILV+YC RV VA + L
Sbjct: 168 PAPEDETICQINEEPG-----YVLFSALGSFYLPLAIILVMYC---RVYVVAKRESRGLK 219
Query: 247 TWMETPRQRSESLSSR----STMVTSSGAPQTTPHRTFG--------GGKAAVVLLAVGG 294
+ ++T + SE ++ R + SG F KAA L V G
Sbjct: 220 SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVG 279
Query: 295 QFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIR 349
F+LCWLP+F + + V +V W+GY NP Y C +++ +
Sbjct: 280 CFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 102 bits (255), Expect = 5e-22
Identities = 96/355 (27%), Positives = 152/355 (42%), Gaps = 40/355 (11%)
Query: 10 SGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAK 69
SGN+S Q P P S +G+ + L L V GN V+ +A
Sbjct: 5 SGNASDSSNCTQPPAPVNISKAILLGV-----------ILGGLILFGVLGNILVILSVA- 52
Query: 70 TPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFD---HALFGEVACRLYLFLSVCFV 126
R V H +V+L A L+ +L SA+F+ + FG V C ++ + V
Sbjct: 53 --CHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 110
Query: 127 SLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEE 186
+ +I+ + I+++RY V +P+RY +T L+ VW +L ++ P+ G W +
Sbjct: 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQ 167
Query: 187 GAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLP 246
AP C + +V+ A+ F LPL +ILV+YC RV VA + L
Sbjct: 168 PAPEDETICQINEEPG-----YVLFSALGSFYLPLAIILVMYC---RVYVVAKRESRGLK 219
Query: 247 TWMETPRQRSESLSSR----STMVTSSGAPQTTPHRTFG--------GGKAAVVLLAVGG 294
+ ++T + SE ++ R + SG F KAA L V G
Sbjct: 220 SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVG 279
Query: 295 QFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIR 349
F+LCWLP+F + + V +V W+GY NP Y C +++ +
Sbjct: 280 CFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 102 bits (255), Expect = 5e-22
Identities = 96/355 (27%), Positives = 152/355 (42%), Gaps = 40/355 (11%)
Query: 10 SGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAK 69
SGN+S Q P P S +G+ + L L V GN V+ +A
Sbjct: 5 SGNASDSSNCTQPPAPVNISKAILLGV-----------ILGGLILFGVLGNILVILSVA- 52
Query: 70 TPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFD---HALFGEVACRLYLFLSVCFV 126
R V H +V+L A L+ +L SA+F+ + FG V C ++ + V
Sbjct: 53 --CHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 110
Query: 127 SLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEE 186
+ +I+ + I+++RY V +P+RY +T L+ VW +L ++ P+ G W +
Sbjct: 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQ 167
Query: 187 GAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLP 246
AP C + +V+ A+ F LPL +ILV+YC RV VA + L
Sbjct: 168 PAPEDETICQINEEPG-----YVLFSALGSFYLPLAIILVMYC---RVYVVAKRESRGLK 219
Query: 247 TWMETPRQRSESLSSR----STMVTSSGAPQTTPHRTFG--------GGKAAVVLLAVGG 294
+ ++T + SE ++ R + SG F KAA L V G
Sbjct: 220 SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVG 279
Query: 295 QFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIR 349
F+LCWLP+F + + V +V W+GY NP Y C +++ +
Sbjct: 280 CFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 102 bits (255), Expect = 5e-22
Identities = 96/355 (27%), Positives = 152/355 (42%), Gaps = 40/355 (11%)
Query: 10 SGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAK 69
SGN+S Q P P S +G+ + L L V GN V+ +A
Sbjct: 5 SGNASDSSNCTQPPAPVNISKAILLGV-----------ILGGLILFGVLGNILVILSVA- 52
Query: 70 TPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFD---HALFGEVACRLYLFLSVCFV 126
R V H +V+L A L+ +L SA+F+ + FG V C ++ + V
Sbjct: 53 --CHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 110
Query: 127 SLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEE 186
+ +I+ + I+++RY V +P+RY +T L+ VW +L ++ P+ G W +
Sbjct: 111 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQ 167
Query: 187 GAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLP 246
AP C + +V+ A+ F LPL +ILV+YC RV VA + L
Sbjct: 168 PAPEDETICQINEEPG-----YVLFSALGSFYLPLAIILVMYC---RVYVVAKRESRGLK 219
Query: 247 TWMETPRQRSESLSSR----STMVTSSGAPQTTPHRTFG--------GGKAAVVLLAVGG 294
+ ++T + SE ++ R + SG F KAA L V G
Sbjct: 220 SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVG 279
Query: 295 QFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIR 349
F+LCWLP+F + + V +V W+GY NP Y C +++ +
Sbjct: 280 CFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK 334
>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
Length = 478
Score = 102 bits (255), Expect = 5e-22
Identities = 96/363 (26%), Positives = 157/363 (43%), Gaps = 40/363 (11%)
Query: 9 SSGNSSTLGRVPQ----TPGPSTASGVP--EVGLRDVASESVALFFMLLLDLTAVAGNAA 62
S + S+LGR+P PG A+ VP V + D A ++ +LL+ LT + GN
Sbjct: 32 SQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTV-ILLVGLTGMLGNLT 90
Query: 63 VMAVIAKTPALRK--FVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF 120
V+ ++ +LR +F+ +L + D L + T P+ SS L+ LFGE C Y F
Sbjct: 91 VIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSS--LYKQWLFGETGCEFYAF 148
Query: 121 LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG 180
F ++++++AI ++RY + P+ + A VL+GVW+ ALA + P G
Sbjct: 149 CGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFG 208
Query: 181 RVSWEEGAPSVPPG--CSLQWSHSAY---CQLFVVVFAVLYFLLPLLLILVVYCSMFRVA 235
W + VP G S W + ++ + + ++ F LPLL+I+ Y +FR
Sbjct: 209 ---W---SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAI 262
Query: 236 RVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQ 295
R + G + ESL R + + K A ++L V
Sbjct: 263 R----ETGRALQTFGACKGNGESLWQRQRLQSEC--------------KMAKIMLLVILL 304
Query: 296 FLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQ 355
F+L W PY + L + T + SV I NP Y + + R +++
Sbjct: 305 FVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQH 364
Query: 356 FVC 358
C
Sbjct: 365 LPC 367
>gi|149944554 somatostatin receptor 4 [Homo sapiens]
Length = 388
Score = 96.7 bits (239), Expect = 4e-20
Identities = 94/371 (25%), Positives = 155/371 (41%), Gaps = 59/371 (15%)
Query: 51 LLDLTAVAGNAAVMAVIAKTPALRKF--VFVFHLCLVDLLAALTLMPLAMLSSSALFDHA 108
L+ L + GNA V+ VI + ++ +++ +L + D L ++ + ++SSA H
Sbjct: 56 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVASSAALRHW 112
Query: 109 LFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWV 168
FG V CR L + + ++ ++ ++V+RY VVHP+R + + +GVW+
Sbjct: 113 PFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWL 172
Query: 169 KALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVY 228
+L + ++P+ C+LQW H A+ +FVV +L FLLP+L I + Y
Sbjct: 173 ASL-LVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCY 231
Query: 229 CSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVV 288
+ R A++ G W + R+RSE +R +
Sbjct: 232 LLIVGKMRAVALRAG----WQQ--RRRSEKKITR-------------------------L 260
Query: 289 LLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQI 348
+L V F+LCW+P++ L +T V V + Y +NP YG
Sbjct: 261 VLMVVVVFVLCWMPFYVVQLLNLFVTSLDAT--VNHVSLILSYANSCANPILYGF----- 313
Query: 349 RGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQ-------GTGC-----PSESWV 396
LS F FF+ L G EE L + G GC P +
Sbjct: 314 ---LSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEA 370
Query: 397 SRPLPSPKQEP 407
+P P K+ P
Sbjct: 371 LQPEPGRKRIP 381
>gi|71999143 opsin 4 isoform 2 [Homo sapiens]
Length = 489
Score = 96.3 bits (238), Expect = 5e-20
Identities = 97/374 (25%), Positives = 159/374 (42%), Gaps = 51/374 (13%)
Query: 9 SSGNSSTLGRVPQ----TPGPSTASGVP--EVGLRDVASESVALFFMLLLDLTAVAGNAA 62
S + S+LGR+P PG A+ VP V + D A ++ +LL+ LT + GN
Sbjct: 32 SQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTV-ILLVGLTGMLGNLT 90
Query: 63 VM-----------AVIAKTPALRK--FVFVFHLCLVDLLAALTLMPLAMLSSSALFDHAL 109
V+ V+ ++ +LR +F+ +L + D L + T P+ SS L+ L
Sbjct: 91 VIYTFCRAVLRGVTVMMQSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSS--LYKQWL 148
Query: 110 FGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVK 169
FGE C Y F F ++++++AI ++RY + P+ + A VL+GVW+
Sbjct: 149 FGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLY 208
Query: 170 ALAMASVPVLGRVSWEEGAPSVPPG--CSLQWSHSAY---CQLFVVVFAVLYFLLPLLLI 224
ALA + P G W + VP G S W + ++ + + ++ F LPLL+I
Sbjct: 209 ALAWSLPPFFG---W---SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLII 262
Query: 225 LVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGK 284
+ Y +FR R + G + ESL R + + K
Sbjct: 263 IYCYIFIFRAIR----ETGRALQTFGACKGNGESLWQRQRLQSEC--------------K 304
Query: 285 AAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCL 344
A ++L V F+L W PY + L + T + SV I NP Y
Sbjct: 305 MAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAIT 364
Query: 345 NRQIRGELSKQFVC 358
+ + R +++ C
Sbjct: 365 HPKYRVAIAQHLPC 378
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 96.3 bits (238), Expect = 5e-20
Identities = 88/366 (24%), Positives = 157/366 (42%), Gaps = 46/366 (12%)
Query: 21 QTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV--- 77
+T S G V RD + + F+ LL L+ + GN V A + + LR V
Sbjct: 2 RTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNF 61
Query: 78 FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAIN 137
FV L + DLL A+ +MP ++ A F FG C +++ + + +IL++ I+
Sbjct: 62 FVISLAVSDLLVAVLVMPWKAVAEIAGFWP--FGSF-CNIWVAFDIMCSTASILNLCVIS 118
Query: 138 VERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPP---- 193
V+RY+ + P RYE +MT ++ W ++ ++ +PV ++SW + P+ P
Sbjct: 119 VDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPV--QLSWHKAKPTSPSDGNA 176
Query: 194 ---GCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVA-----RVAAMQHGPL 245
++ S+ + + + +V+ F +P+ +++V Y ++R+A R+AA+
Sbjct: 177 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAAL----- 231
Query: 246 PTWMETPRQRSESLSSRSTMVTSSGAPQ--TTPHRTFGGG-----KAAVVLLAVGGQFLL 298
+R+ + T +G P + P +F K L + G F+
Sbjct: 232 --------ERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVC 283
Query: 299 CWLPYFSFHLYVAL----SAQPIS-TGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELS 353
CWLP+F + + QP V W G+ + NP Y N R S
Sbjct: 284 CWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIY-AFNADFRKAFS 342
Query: 354 KQFVCF 359
C+
Sbjct: 343 TLLGCY 348
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 94.0 bits (232), Expect = 3e-19
Identities = 80/360 (22%), Positives = 151/360 (41%), Gaps = 42/360 (11%)
Query: 25 PSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRK--FVFVFHL 82
P ASG E + V + L+ L +AGN V+ + LR+ + L
Sbjct: 64 PDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL 123
Query: 83 CLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYY 142
L DL A+ +MP ++ + +FG C +++ + V + +I+++ I+++RY
Sbjct: 124 ALADLSVAVAVMPFVSVTD-LIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYL 182
Query: 143 YVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHS 202
+ P+ Y VR +A +++ VW+ + ++ P+ G W + + C +
Sbjct: 183 GITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG---WAQNV-NDDKVCLISQDFG 238
Query: 203 AYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSR 262
+ + + F +P+ ++L +Y +++ AR +A +H + PR +S+ +
Sbjct: 239 -----YTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH----KFPGFPRVEPDSVIAL 289
Query: 263 STMV-------TSSGAPQTTPHRTFG------GGKAAVVLLAVGGQFLLCWLPYFSFHLY 309
+ +V + + H KAA L + G F +CWLP+F
Sbjct: 290 NGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFF----- 344
Query: 310 VALSAQPISTGQ--------VESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFK 361
+ +A+P G VE W+GY NPF Y NR +R C ++
Sbjct: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 94.0 bits (232), Expect = 3e-19
Identities = 80/360 (22%), Positives = 151/360 (41%), Gaps = 42/360 (11%)
Query: 25 PSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRK--FVFVFHL 82
P ASG E + V + L+ L +AGN V+ + LR+ + L
Sbjct: 64 PDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL 123
Query: 83 CLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYY 142
L DL A+ +MP ++ + +FG C +++ + V + +I+++ I+++RY
Sbjct: 124 ALADLSVAVAVMPFVSVTD-LIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYL 182
Query: 143 YVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHS 202
+ P+ Y VR +A +++ VW+ + ++ P+ G W + + C +
Sbjct: 183 GITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG---WAQNV-NDDKVCLISQDFG 238
Query: 203 AYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSR 262
+ + + F +P+ ++L +Y +++ AR +A +H + PR +S+ +
Sbjct: 239 -----YTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH----KFPGFPRVEPDSVIAL 289
Query: 263 STMV-------TSSGAPQTTPHRTFG------GGKAAVVLLAVGGQFLLCWLPYFSFHLY 309
+ +V + + H KAA L + G F +CWLP+F
Sbjct: 290 NGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFF----- 344
Query: 310 VALSAQPISTGQ--------VESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFK 361
+ +A+P G VE W+GY NPF Y NR +R C ++
Sbjct: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 94.0 bits (232), Expect = 3e-19
Identities = 80/360 (22%), Positives = 151/360 (41%), Gaps = 42/360 (11%)
Query: 25 PSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRK--FVFVFHL 82
P ASG E + V + L+ L +AGN V+ + LR+ + L
Sbjct: 64 PDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL 123
Query: 83 CLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYY 142
L DL A+ +MP ++ + +FG C +++ + V + +I+++ I+++RY
Sbjct: 124 ALADLSVAVAVMPFVSVTD-LIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYL 182
Query: 143 YVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHS 202
+ P+ Y VR +A +++ VW+ + ++ P+ G W + + C +
Sbjct: 183 GITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG---WAQNV-NDDKVCLISQDFG 238
Query: 203 AYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSR 262
+ + + F +P+ ++L +Y +++ AR +A +H + PR +S+ +
Sbjct: 239 -----YTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKH----KFPGFPRVEPDSVIAL 289
Query: 263 STMV-------TSSGAPQTTPHRTFG------GGKAAVVLLAVGGQFLLCWLPYFSFHLY 309
+ +V + + H KAA L + G F +CWLP+F
Sbjct: 290 NGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFF----- 344
Query: 310 VALSAQPISTGQ--------VESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFK 361
+ +A+P G VE W+GY NPF Y NR +R C ++
Sbjct: 345 LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYR 404
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 90.1 bits (222), Expect = 4e-18
Identities = 87/370 (23%), Positives = 157/370 (42%), Gaps = 42/370 (11%)
Query: 3 SSPIPQSSGNSSTLGRVPQTPGPST---ASGVPEVGLRDVASESVALFFMLLLDLTAVAG 59
++P+P + ++ L VP +P S AS PE L + + L M L+ L VAG
Sbjct: 19 AAPLPDGAATAARL-LVPASPPASLLPPASESPEP-LSQQWTAGMGLL-MALIVLLIVAG 75
Query: 60 NAAVMAVIAKTPALRKF--VFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRL 117
N V+ IAKTP L+ +F+ L DL+ L ++P ++ ++ +G C L
Sbjct: 76 NVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFG--ATIVVWGRWEYGSFFCEL 133
Query: 118 YLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVP 177
+ + V V+ +I ++ I ++RY + P RY+ +T ++ VW + ++ +P
Sbjct: 134 WTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLP 193
Query: 178 VLGRVSWEEGAPSVPPGCSLQWSHSAYC-----QLFVVVFAVLYFLLPLLLILVVYCSMF 232
+L + W C ++ C + + + +V+ F +PL ++ VY +F
Sbjct: 194 IL--MHWWRAESDEARRC---YNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVF 248
Query: 233 R-------------------VARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQ 273
R AR + P+P P + ++ + + + A +
Sbjct: 249 REAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGK 308
Query: 274 TTPHR--TFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGY 331
P R KA L + G F LCWLP+F ++ A + + ++ W+GY
Sbjct: 309 RRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE-LVPDRLFVFFNWLGY 367
Query: 332 FCFTSNPFFY 341
NP Y
Sbjct: 368 ANSAFNPIIY 377
>gi|4557865 somatostatin receptor 5 [Homo sapiens]
Length = 364
Score = 87.4 bits (215), Expect = 2e-17
Identities = 97/359 (27%), Positives = 154/359 (42%), Gaps = 56/359 (15%)
Query: 5 PIPQSSGNSSTLGRVPQTPGPSTASG-VPEVGLRDVASESVALFFMLLLDLTAVAGNAAV 63
P S N+S+ G T G P G R V + LL+ + GN V
Sbjct: 6 PASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAV----LVPVLYLLVCAAGLGGNTLV 61
Query: 64 MAVIAKTPALRKF--VFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFL 121
+ V+ + ++ +++ +L + D+L L L LA ++++ + FG V CRL + L
Sbjct: 62 IYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWP---FGPVLCRLVMTL 118
Query: 122 SVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVL-VGVWVKALAMASVPVLG 180
++ ++ ++V+RY VVHP+ R VA + WV +L M S+P+L
Sbjct: 119 DGVNQFTSVFCLTVMSVDRYLAVVHPLS-SARWRRPRVAKLASAAAWVLSLCM-SLPLLV 176
Query: 181 RVSWEEGAPSVPPGCSLQWSH--SAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVA 238
+EG C+ W + +F++ AVL F PLL+I + Y + R A
Sbjct: 177 FADVQEGGT-----CNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAA 231
Query: 239 AMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLL 298
++ G + R+RSE +R +V VVL+ G
Sbjct: 232 GVRVGCV-------RRRSERKVTRMVLV--------------------VVLVFAG----- 259
Query: 299 CWLPYFS---FHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSK 354
CWLP+F+ +L VAL +P S G VV + Y +NP YG L+ R K
Sbjct: 260 CWLPFFTVNIVNLAVALPQEPASAGLYFFVVI-LSYANSCANPVLYGFLSDNFRQSFQK 317
>gi|28875799 cholecystokinin B receptor [Homo sapiens]
Length = 447
Score = 85.9 bits (211), Expect = 7e-17
Identities = 90/380 (23%), Positives = 153/380 (40%), Gaps = 53/380 (13%)
Query: 12 NSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTP 71
NSS++G + P +G E+ L ++ + ++ L +V GN ++ V+ +
Sbjct: 30 NSSSVGNLSCEPPRIRGAGTRELEL------AIRITLYAVIFLMSVGGNMLIIVVLGLSR 83
Query: 72 ALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLA 129
LR F+ L + DLL A+ MP +L + L +FG V C+ +L VS++
Sbjct: 84 RLRTVTNAFLLSLAVSDLLLAVACMPFTLLPN--LMGTFIFGTVICKAVSYLMGVSVSVS 141
Query: 130 ILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVW-VKALAMASVPVLGRVSWEEGA 188
LS+ AI +ERY + P++ V T A V+V W + L M PV V +
Sbjct: 142 TLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVV--QPVG 199
Query: 189 PSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRV-------------- 234
P V C +W + Q + V+ +L F +P +++ V Y + R
Sbjct: 200 PRVLQ-CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSD 258
Query: 235 ARVAAMQHGPLP----------------------TWMETPRQRSESLSSRSTMVTSSGAP 272
++ G LP +++ PR R + T
Sbjct: 259 SQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGS 318
Query: 273 QTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVAL---SAQPISTGQVESVVTWI 329
+ T + + +LL + F LCWLP +S + + A A +G S + +
Sbjct: 319 RPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLL 378
Query: 330 GYFCFTSNPFFYGCLNRQIR 349
Y NP Y ++R+ R
Sbjct: 379 SYASACVNPLVYCFMHRRFR 398
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,014,841
Number of Sequences: 37866
Number of extensions: 866194
Number of successful extensions: 5136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 362
Number of HSP's successfully gapped in prelim test: 292
Number of HSP's that attempted gapping in prelim test: 4101
Number of HSP's gapped (non-prelim): 907
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.