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Search of human proteins with 56550051
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56550051 ubiquitin specific protease 39 [Homo sapiens]
(565 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56550051 ubiquitin specific protease 39 [Homo sapiens] 1145 0.0
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 102 1e-21
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 94 3e-19
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 94 3e-19
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 89 1e-17
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 89 1e-17
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 89 1e-17
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 75 2e-13
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 75 2e-13
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 75 2e-13
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 70 7e-12
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 69 1e-11
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 68 2e-11
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 68 2e-11
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 68 3e-11
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 68 3e-11
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 68 3e-11
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 67 6e-11
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 67 6e-11
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 66 7e-11
gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo ... 66 1e-10
gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo ... 66 1e-10
gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 65 1e-10
gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 65 1e-10
gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo ... 65 1e-10
gi|239742285 PREDICTED: hypothetical protein XP_002342486 [Homo ... 65 1e-10
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 65 1e-10
gi|239742295 PREDICTED: hypothetical protein XP_002342479 [Homo ... 65 2e-10
gi|239742280 PREDICTED: hypothetical protein XP_002342473 [Homo ... 65 2e-10
gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 64 3e-10
>gi|56550051 ubiquitin specific protease 39 [Homo sapiens]
Length = 565
Score = 1145 bits (2963), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAR 60
MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAR
Sbjct: 1 MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAR 60
Query: 61 EAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDF 120
EAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDF
Sbjct: 61 EAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDF 120
Query: 121 EKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYE 180
EKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYE
Sbjct: 121 EKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYE 180
Query: 181 IIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVL 240
IIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVL
Sbjct: 181 IIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVL 240
Query: 241 QALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEML 300
QALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEML
Sbjct: 241 QALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEML 300
Query: 301 QAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKL 360
QAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKL
Sbjct: 301 QAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKL 360
Query: 361 PHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILA 420
PHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILA
Sbjct: 361 PHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILA 420
Query: 421 KFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDL 480
KFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDL
Sbjct: 421 KFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDL 480
Query: 481 REYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQ 540
REYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQ
Sbjct: 481 REYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQ 540
Query: 541 MITLSEAYIQIWKRRDNDETNQQGA 565
MITLSEAYIQIWKRRDNDETNQQGA
Sbjct: 541 MITLSEAYIQIWKRRDNDETNQQGA 565
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 102 bits (253), Expect = 1e-21
Identities = 125/499 (25%), Positives = 198/499 (39%), Gaps = 95/499 (19%)
Query: 124 CSISLSHINAYACLVCGKYFQGRGLKSHAYIH----------------SVQFSHHVFLNL 167
CS+ S+ + + CL C GR + HA H + H V ++
Sbjct: 29 CSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDC 88
Query: 168 HTLKFYCLP-DNYEIIDSSL-------EDITYVLKPTFT------KQQIANLDKQAKLSR 213
+ YC D++ + D+ L E + + FT ++ + N +KL +
Sbjct: 89 SSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHKKRKLLENSTLNSKLLK 148
Query: 214 AYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEED--NYKNIK-------- 263
TT + GL N+ + NA+LQ+LSN+ YF E +N K
Sbjct: 149 VNGSTTAICA-TGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYH 207
Query: 264 -RPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDF 322
R GD LV+ F + + LW + + SP E L VV F+ +Q D +F
Sbjct: 208 TRSQGDNNVSLVEEFRKTLCALW--QGSQTAFSP-ESLFYVVWKIMPNFRGYQQQDAHEF 264
Query: 323 LSWFLNALH-------------------SALGGTKK----KKKTIVTDVFQGSMRIFTKK 359
+ + L+ LH S L + K T+VT +F G ++
Sbjct: 265 MRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQ----- 319
Query: 360 LPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNIL 419
E L+ E ++ F+ L+LD+P+ K K Q P L + L
Sbjct: 320 --------NEVNCLICGTESRKF---DPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCL 368
Query: 420 AKFNGITE-KEYKTY-------KENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIV 471
F + E E + Y K+ K+F + KLP L +KRF + K T V
Sbjct: 369 RSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYV 428
Query: 472 NFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGK-PSEGSYRIHVLHHGTGKWYELQ 530
FP+ +D++ YL E + ++ YDL A +VH G G Y + H G+W+
Sbjct: 429 EFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHE--GRWFHFN 486
Query: 531 DLQVTDILPQMITLSEAYI 549
D VT + + ++AYI
Sbjct: 487 DSTVTLTDEETVVKAKAYI 505
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/353 (24%), Positives = 157/353 (44%), Gaps = 42/353 (11%)
Query: 223 GIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMR 282
G+ GL N+ + N++LQ LSN LR+Y L+ +++ + LV+ F +L++
Sbjct: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHG-SNAHTALVEEFAKLIQ 114
Query: 283 KLW--NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKK 340
+W +P + VSP E + + + F Q D +FL + L+ LH+ + +
Sbjct: 115 TIWTSSPNDV---VSPSEFKTQIQRYAPR-FVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170
Query: 341 KKTIVTDVF-----QGSMRIFTKKLPHPD------LPAEEKEQLLHND-EYQETMVESTF 388
K+ ++ + +++ K L D + K L D Y T+ +
Sbjct: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP-- 228
Query: 389 MYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFN--GITEKEYKTY------KENFLKR 440
+ L LP A + P+V L + + F + + + K ++ +K+
Sbjct: 229 -FWDLSLPIA--------KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKK 279
Query: 441 FQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLI 500
F + + P L+ +KRF+++ K T VNFP+ ++DLRE+ SE + Y+L
Sbjct: 280 FSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENT----NHAVYNLY 335
Query: 501 ANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWK 553
A H G G Y + GTG+W+ D VT + + S+AY+ ++
Sbjct: 336 AVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/353 (24%), Positives = 157/353 (44%), Gaps = 42/353 (11%)
Query: 223 GIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMR 282
G+ GL N+ + N++LQ LSN LR+Y L+ +++ + LV+ F +L++
Sbjct: 265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHG-SNAHTALVEEFAKLIQ 323
Query: 283 KLW--NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKK 340
+W +P + VSP E + + + F Q D +FL + L+ LH+ + +
Sbjct: 324 TIWTSSPNDV---VSPSEFKTQIQRYAPR-FVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 379
Query: 341 KKTIVTDVF-----QGSMRIFTKKLPHPD------LPAEEKEQLLHND-EYQETMVESTF 388
K+ ++ + +++ K L D + K L D Y T+ +
Sbjct: 380 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP-- 437
Query: 389 MYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFN--GITEKEYKTY------KENFLKR 440
+ L LP A + P+V L + + F + + + K ++ +K+
Sbjct: 438 -FWDLSLPIA--------KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKK 488
Query: 441 FQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLI 500
F + + P L+ +KRF+++ K T VNFP+ ++DLRE+ SE + Y+L
Sbjct: 489 FSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENT----NHAVYNLY 544
Query: 501 ANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWK 553
A H G G Y + GTG+W+ D VT + + S+AY+ ++
Sbjct: 545 AVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 597
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 88.6 bits (218), Expect = 1e-17
Identities = 92/380 (24%), Positives = 168/380 (44%), Gaps = 45/380 (11%)
Query: 194 KPT-FTKQQIANLDKQA--KLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLR 250
KPT + K +I+ L L+ + G+ P + GL N+ Y N++LQ L N P L
Sbjct: 745 KPTCYPKAEISRLSASQIRNLNPVFGGSG--PALTGLRNLGNTCYMNSILQCLCNAPHLA 802
Query: 251 NYF-----LEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVL 305
+YF ++ N N+ G++ + FG +M+ LW + ++SP + +
Sbjct: 803 DYFNRNCYQDDINRSNLLGHKGEV----AEEFGIIMKALWTGQY--RYISPKDFKITIGK 856
Query: 306 CSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKK-----TIVTDVFQGSMRIFTK-- 358
+ + F Q D + L + ++ LH L +K+ D F+ + + K
Sbjct: 857 INDQ-FAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHK 915
Query: 359 KLPHPDLPAEEKEQLLHNDE----YQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVP 414
+L + A + Q + ++++ FMYL+L PL K L
Sbjct: 916 QLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSL-----PLASTSKCTL----QD 966
Query: 415 LFNILAKFNGITEKE-----YKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPT 469
+ +K +T+ + + + LK+ ++ KLPP L+ +KRF+ + + +K T
Sbjct: 967 CLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQT 1026
Query: 470 IVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYEL 529
V+FP+ N+DL +Y+ + K Y+L + H G G Y + + +W++
Sbjct: 1027 SVDFPLENLDLSQYVIGPKNNLKK---YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
Query: 530 QDLQVTDILPQMITLSEAYI 549
D +V+DI + S AYI
Sbjct: 1084 DDHEVSDISVSSVKSSAAYI 1103
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 88.6 bits (218), Expect = 1e-17
Identities = 92/380 (24%), Positives = 168/380 (44%), Gaps = 45/380 (11%)
Query: 194 KPT-FTKQQIANLDKQA--KLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLR 250
KPT + K +I+ L L+ + G+ P + GL N+ Y N++LQ L N P L
Sbjct: 745 KPTCYPKAEISRLSASQIRNLNPVFGGSG--PALTGLRNLGNTCYMNSILQCLCNAPHLA 802
Query: 251 NYF-----LEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVL 305
+YF ++ N N+ G++ + FG +M+ LW + ++SP + +
Sbjct: 803 DYFNRNCYQDDINRSNLLGHKGEV----AEEFGIIMKALWTGQY--RYISPKDFKITIGK 856
Query: 306 CSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKK-----TIVTDVFQGSMRIFTK-- 358
+ + F Q D + L + ++ LH L +K+ D F+ + + K
Sbjct: 857 INDQ-FAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHK 915
Query: 359 KLPHPDLPAEEKEQLLHNDE----YQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVP 414
+L + A + Q + ++++ FMYL+L PL K L
Sbjct: 916 QLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSL-----PLASTSKCTL----QD 966
Query: 415 LFNILAKFNGITEKE-----YKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPT 469
+ +K +T+ + + + LK+ ++ KLPP L+ +KRF+ + + +K T
Sbjct: 967 CLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQT 1026
Query: 470 IVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYEL 529
V+FP+ N+DL +Y+ + K Y+L + H G G Y + + +W++
Sbjct: 1027 SVDFPLENLDLSQYVIGPKNNLKK---YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
Query: 530 QDLQVTDILPQMITLSEAYI 549
D +V+DI + S AYI
Sbjct: 1084 DDHEVSDISVSSVKSSAAYI 1103
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 88.6 bits (218), Expect = 1e-17
Identities = 92/380 (24%), Positives = 168/380 (44%), Gaps = 45/380 (11%)
Query: 194 KPT-FTKQQIANLDKQA--KLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLR 250
KPT + K +I+ L L+ + G+ P + GL N+ Y N++LQ L N P L
Sbjct: 745 KPTCYPKAEISRLSASQIRNLNPVFGGSG--PALTGLRNLGNTCYMNSILQCLCNAPHLA 802
Query: 251 NYF-----LEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVL 305
+YF ++ N N+ G++ + FG +M+ LW + ++SP + +
Sbjct: 803 DYFNRNCYQDDINRSNLLGHKGEV----AEEFGIIMKALWTGQY--RYISPKDFKITIGK 856
Query: 306 CSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKK-----TIVTDVFQGSMRIFTK-- 358
+ + F Q D + L + ++ LH L +K+ D F+ + + K
Sbjct: 857 INDQ-FAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHK 915
Query: 359 KLPHPDLPAEEKEQLLHNDE----YQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVP 414
+L + A + Q + ++++ FMYL+L PL K L
Sbjct: 916 QLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSL-----PLASTSKCTL----QD 966
Query: 415 LFNILAKFNGITEKE-----YKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPT 469
+ +K +T+ + + + LK+ ++ KLPP L+ +KRF+ + + +K T
Sbjct: 967 CLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQT 1026
Query: 470 IVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYEL 529
V+FP+ N+DL +Y+ + K Y+L + H G G Y + + +W++
Sbjct: 1027 SVDFPLENLDLSQYVIGPKNNLKK---YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKF 1083
Query: 530 QDLQVTDILPQMITLSEAYI 549
D +V+DI + S AYI
Sbjct: 1084 DDHEVSDISVSSVKSSAAYI 1103
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 74.7 bits (182), Expect = 2e-13
Identities = 66/258 (25%), Positives = 108/258 (41%), Gaps = 35/258 (13%)
Query: 104 HCPYLDTINRSVLDFDFEKLCSI----SLSHINAYACLV--CGKYFQGRGLKSHAYIHSV 157
HCP+LD++ + +K + N +ACL C G H+ IHS
Sbjct: 38 HCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQ 97
Query: 158 QFSHHVFLNLHTLKFYC------------------LP---DNYEIIDSSLEDITYVLKPT 196
+ H++ +NL TL+ +C LP ++I ++S++D T
Sbjct: 98 ETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTT 157
Query: 197 FTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEE 256
+A D + + G+ GL NI Y NA LQALSN PPL +FL+
Sbjct: 158 LKTPLVAVFD-DLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC 216
Query: 257 DNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQ 316
+ P + + + +LM +LW+ ++ V P + Q + + TF+ Q
Sbjct: 217 GGLARTDKKPA-----ICKSYLKLMTELWH-KSRPGSVVPTTLFQGIKTVN-PTFRGYSQ 269
Query: 317 GDGVDFLSWFLNALHSAL 334
D +FL ++ LH L
Sbjct: 270 QDAQEFLRCLMDLLHEEL 287
Score = 67.0 bits (162), Expect = 4e-11
Identities = 38/128 (29%), Positives = 68/128 (53%), Gaps = 3/128 (2%)
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
N +K ++ P L +KRF F K T V+FP+ +DL+ +L+++ A +
Sbjct: 590 NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA--QIV 647
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555
TYDL++ I H G S G Y + ++ WYE D VT++ + +EAY+ ++ R+
Sbjct: 648 TYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYV-LFYRK 706
Query: 556 DNDETNQQ 563
++E ++
Sbjct: 707 SSEEAQKE 714
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 74.7 bits (182), Expect = 2e-13
Identities = 66/258 (25%), Positives = 108/258 (41%), Gaps = 35/258 (13%)
Query: 104 HCPYLDTINRSVLDFDFEKLCSI----SLSHINAYACLV--CGKYFQGRGLKSHAYIHSV 157
HCP+LD++ + +K + N +ACL C G H+ IHS
Sbjct: 38 HCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQ 97
Query: 158 QFSHHVFLNLHTLKFYC------------------LP---DNYEIIDSSLEDITYVLKPT 196
+ H++ +NL TL+ +C LP ++I ++S++D T
Sbjct: 98 ETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTT 157
Query: 197 FTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEE 256
+A D + + G+ GL NI Y NA LQALSN PPL +FL+
Sbjct: 158 LKTPLVAVFD-DLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC 216
Query: 257 DNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQ 316
+ P + + + +LM +LW+ ++ V P + Q + + TF+ Q
Sbjct: 217 GGLARTDKKPA-----ICKSYLKLMTELWH-KSRPGSVVPTTLFQGIKTVN-PTFRGYSQ 269
Query: 317 GDGVDFLSWFLNALHSAL 334
D +FL ++ LH L
Sbjct: 270 QDAQEFLRCLMDLLHEEL 287
Score = 67.0 bits (162), Expect = 4e-11
Identities = 38/128 (29%), Positives = 68/128 (53%), Gaps = 3/128 (2%)
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
N +K ++ P L +KRF F K T V+FP+ +DL+ +L+++ A +
Sbjct: 598 NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA--QIV 655
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555
TYDL++ I H G S G Y + ++ WYE D VT++ + +EAY+ ++ R+
Sbjct: 656 TYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYV-LFYRK 714
Query: 556 DNDETNQQ 563
++E ++
Sbjct: 715 SSEEAQKE 722
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 74.7 bits (182), Expect = 2e-13
Identities = 66/258 (25%), Positives = 108/258 (41%), Gaps = 35/258 (13%)
Query: 104 HCPYLDTINRSVLDFDFEKLCSI----SLSHINAYACLV--CGKYFQGRGLKSHAYIHSV 157
HCP+LD++ + +K + N +ACL C G H+ IHS
Sbjct: 7 HCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQ 66
Query: 158 QFSHHVFLNLHTLKFYC------------------LP---DNYEIIDSSLEDITYVLKPT 196
+ H++ +NL TL+ +C LP ++I ++S++D T
Sbjct: 67 ETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQIQENSVQDFKIPSNTT 126
Query: 197 FTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEE 256
+A D + + G+ GL NI Y NA LQALSN PPL +FL+
Sbjct: 127 LKTPLVAVFD-DLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC 185
Query: 257 DNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQ 316
+ P + + + +LM +LW+ ++ V P + Q + + TF+ Q
Sbjct: 186 GGLARTDKKPA-----ICKSYLKLMTELWH-KSRPGSVVPTTLFQGIKTVN-PTFRGYSQ 238
Query: 317 GDGVDFLSWFLNALHSAL 334
D +FL ++ LH L
Sbjct: 239 QDAQEFLRCLMDLLHEEL 256
Score = 67.0 bits (162), Expect = 4e-11
Identities = 38/128 (29%), Positives = 68/128 (53%), Gaps = 3/128 (2%)
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
N +K ++ P L +KRF F K T V+FP+ +DL+ +L+++ A +
Sbjct: 567 NGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA--QIV 624
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555
TYDL++ I H G S G Y + ++ WYE D VT++ + +EAY+ ++ R+
Sbjct: 625 TYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYV-LFYRK 683
Query: 556 DNDETNQQ 563
++E ++
Sbjct: 684 SSEEAQKE 691
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 69.7 bits (169), Expect = 7e-12
Identities = 106/491 (21%), Positives = 191/491 (38%), Gaps = 90/491 (18%)
Query: 123 LCSISLSHINA-YACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEI 181
+C + H+N ++CL C F G K H + H+ H++ ++L YC I
Sbjct: 62 ICHVCGVHLNRLHSCLYC--VFFGCFTKKHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYI 119
Query: 182 IDSSLEDITYVLKPTF---------------TKQQIANLDKQAKLSRAYDGTTYLPGIVG 226
D +E I + TK+++ L K + T G+ G
Sbjct: 120 YDKDMEIIAKEEQRKAWKMQGVGEKFSTWEPTKRELELLKHNPKRRKITSNCTI--GLRG 177
Query: 227 LNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWN 286
L N+ + N ++QAL++ P LR++FL + + ++ P ++ + F E
Sbjct: 178 LINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEMSSLFQEF------ 231
Query: 287 PRNFKAHVSPH--EMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKT- 343
+ H SPH L +V + +Q D +FL L+ LH G KK
Sbjct: 232 ---YSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDDNGKKAN 288
Query: 344 -------IVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLP 396
I+ +F G L ++ Q+ H T ++ F ++LDLP
Sbjct: 289 NPNHCNCIIDQIFTGG------------LQSDVTCQVCHG---VSTTID-PFWDISLDLP 332
Query: 397 TA-----PLYKDEK------EQLIIPQVPLFNILAKFN-----GITEK----EYKTYKEN 436
+ PL + E + L + L +F G + K +Y+E+
Sbjct: 333 GSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQES 392
Query: 437 FLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLS----------- 485
K+ + KLP F +KRF + K T V+FP+ +D+ +++
Sbjct: 393 -TKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPL-ELDMTPFMASSKESRMNGQY 450
Query: 486 -EEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITL 544
+ +++ + Y L A + H G G Y + H +W++ D +T + +
Sbjct: 451 QQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQH-KDQWFKCDDAIITKASIKDVLD 509
Query: 545 SEAYIQIWKRR 555
SE Y+ + ++
Sbjct: 510 SEGYLLFYHKQ 520
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 68.9 bits (167), Expect = 1e-11
Identities = 104/492 (21%), Positives = 187/492 (38%), Gaps = 79/492 (16%)
Query: 123 LCSISLSHINA-YACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEI 181
+C + +H+N ++CL C F G + H + H+ HH+ ++L+ YC +
Sbjct: 235 ICHVCSTHMNRLHSCLSC--VFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYV 292
Query: 182 IDSSLEDITYVLKPTF-----------------------------TKQQIANLDKQAKLS 212
D +E I K TK+Q L K K
Sbjct: 293 YDKDIEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKR 352
Query: 213 RAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFL 272
R + Y G+ GL N+ + N ++QAL+++P L+++FL D +K I P
Sbjct: 353 RKK--SVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFL-SDKHKCIMTSPS---LC 406
Query: 273 LVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALH- 331
LV L +++ H+ P+++L + + ++ +Q D +FL L+ LH
Sbjct: 407 LVCEMSSLFHAMYSGSR-TPHI-PYKLLHLIWIHAEHLAGY-RQQDAHEFLIAILDVLHR 463
Query: 332 ---SALGGTKKKK----KTIVTDVFQGSMR----------IFTKKLPHPDLPAEEKEQLL 374
GG + I+ +F G ++ + T P D+ +
Sbjct: 464 HSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCA 523
Query: 375 HNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYK 434
D +ST + +P P D + P+ + K N ++Y+
Sbjct: 524 TFDSQNPERADST-VSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSC-----QSYQ 577
Query: 435 ENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQA---- 490
E+ K+ + KLP F +KRF K T ++FP+ +D+ +L+ ++
Sbjct: 578 ES-TKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPL-ELDMTPFLASTKESRMKE 635
Query: 491 -------VHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMIT 543
V Y L A I H G G Y + +W+ D +T + +
Sbjct: 636 GQPPTDCVPNENKYSLFAVINHHGTLESGHY-TSFIRQQKDQWFSCDDAIITKATIEDLL 694
Query: 544 LSEAYIQIWKRR 555
SE Y+ + ++
Sbjct: 695 YSEGYLLFYHKQ 706
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 68.2 bits (165), Expect = 2e-11
Identities = 38/120 (31%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 439 KRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYD 498
K+F L LP L+ +KRF+ N ++ +K T+V FPI +++ E++ + YD
Sbjct: 810 KKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV---CNLSARPYVYD 866
Query: 499 LIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDND 558
LIA H G G Y + + GKWY D V+ I AY+ ++RRD++
Sbjct: 867 LIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 926
Score = 64.7 bits (156), Expect = 2e-10
Identities = 40/120 (33%), Positives = 65/120 (54%), Gaps = 4/120 (3%)
Query: 222 PGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRP-PGDIMFLLVQRFGEL 280
PG+ GL N+ + N+ LQ LSN PL +YFL+++ I R P + + + + EL
Sbjct: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
Query: 281 MRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKK 340
++++W+ R+ AHV+P M + V F +Q D + L++ L+ LH L KKK
Sbjct: 359 IKQMWSGRD--AHVAP-RMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK 415
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 68.2 bits (165), Expect = 2e-11
Identities = 38/120 (31%), Positives = 60/120 (50%), Gaps = 3/120 (2%)
Query: 439 KRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYD 498
K+F L LP L+ +KRF+ N ++ +K T+V FPI +++ E++ + YD
Sbjct: 763 KKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV---CNLSARPYVYD 819
Query: 499 LIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDND 558
LIA H G G Y + + GKWY D V+ I AY+ ++RRD++
Sbjct: 820 LIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDE 879
Score = 64.7 bits (156), Expect = 2e-10
Identities = 40/120 (33%), Positives = 65/120 (54%), Gaps = 4/120 (3%)
Query: 222 PGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRP-PGDIMFLLVQRFGEL 280
PG+ GL N+ + N+ LQ LSN PL +YFL+++ I R P + + + + EL
Sbjct: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
Query: 281 MRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKK 340
++++W+ R+ AHV+P M + V F +Q D + L++ L+ LH L KKK
Sbjct: 312 IKQMWSGRD--AHVAP-RMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK 368
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 67.8 bits (164), Expect = 3e-11
Identities = 36/128 (28%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
N +K ++ +LP L +KRF + K + V+FP+ +DLR +L++E + + T
Sbjct: 568 NGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTS--QIT 625
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555
TYDL++ I H G G Y + + G+WYE D VT++ ++ +E Y+ +++
Sbjct: 626 TYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKS 685
Query: 556 DNDETNQQ 563
+ ++
Sbjct: 686 SEEAMRER 693
Score = 65.5 bits (158), Expect = 1e-10
Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 24/247 (9%)
Query: 105 CPYLDTIN---RSVLDFDFEKLC-SISLSHINAYACL--VCGKYFQGRGLKSHAYIHSVQ 158
CP+LD+I + L + C S ++ N +ACL C G H+ IH+
Sbjct: 8 CPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQA 67
Query: 159 FSHHVFLNLHTLKFYCLPDNYEI-IDSSLEDITYVLKPTFTKQQIANLDKQAKL------ 211
H++ +NL T + +C E+ ++ L F++Q K
Sbjct: 68 KKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVA 127
Query: 212 ----SRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPG 267
S + D G+ G+ N+ + Y NA LQALSN PPL +FLE + P
Sbjct: 128 DEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPA 187
Query: 268 DIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFL 327
L + + +L+ ++W+ + ++V P + + L + F+ Q D +FL +
Sbjct: 188 -----LCKSYQKLVSEVWHKKR-PSYVVPTSLSHGIKLVN-PMFRGYAQQDTQEFLRCLM 240
Query: 328 NALHSAL 334
+ LH L
Sbjct: 241 DQLHEEL 247
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 67.8 bits (164), Expect = 3e-11
Identities = 36/128 (28%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
N +K ++ +LP L +KRF + K + V+FP+ +DLR +L++E + + T
Sbjct: 568 NGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTS--QIT 625
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555
TYDL++ I H G G Y + + G+WYE D VT++ ++ +E Y+ +++
Sbjct: 626 TYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKS 685
Query: 556 DNDETNQQ 563
+ ++
Sbjct: 686 SEEAMRER 693
Score = 65.5 bits (158), Expect = 1e-10
Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 24/247 (9%)
Query: 105 CPYLDTIN---RSVLDFDFEKLC-SISLSHINAYACL--VCGKYFQGRGLKSHAYIHSVQ 158
CP+LD+I + L + C S ++ N +ACL C G H+ IH+
Sbjct: 8 CPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQA 67
Query: 159 FSHHVFLNLHTLKFYCLPDNYEI-IDSSLEDITYVLKPTFTKQQIANLDKQAKL------ 211
H++ +NL T + +C E+ ++ L F++Q K
Sbjct: 68 KKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVA 127
Query: 212 ----SRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPG 267
S + D G+ G+ N+ + Y NA LQALSN PPL +FLE + P
Sbjct: 128 DEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPA 187
Query: 268 DIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFL 327
L + + +L+ ++W+ + ++V P + + L + F+ Q D +FL +
Sbjct: 188 -----LCKSYQKLVSEVWHKKR-PSYVVPTSLSHGIKLVN-PMFRGYAQQDTQEFLRCLM 240
Query: 328 NALHSAL 334
+ LH L
Sbjct: 241 DQLHEEL 247
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 67.8 bits (164), Expect = 3e-11
Identities = 36/128 (28%), Positives = 68/128 (53%), Gaps = 2/128 (1%)
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
N +K ++ +LP L +KRF + K + V+FP+ +DLR +L++E + + T
Sbjct: 568 NGVKYCKVLRLPEILCIHLKRFRHEVMYSFKINSHVSFPLEGLDLRPFLAKECTS--QIT 625
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555
TYDL++ I H G G Y + + G+WYE D VT++ ++ +E Y+ +++
Sbjct: 626 TYDLLSVICHHGTAGSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAEGYVLFYRKS 685
Query: 556 DNDETNQQ 563
+ ++
Sbjct: 686 SEEAMRER 693
Score = 65.5 bits (158), Expect = 1e-10
Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 24/247 (9%)
Query: 105 CPYLDTIN---RSVLDFDFEKLC-SISLSHINAYACL--VCGKYFQGRGLKSHAYIHSVQ 158
CP+LD+I + L + C S ++ N +ACL C G H+ IH+
Sbjct: 8 CPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESFADHSTIHAQA 67
Query: 159 FSHHVFLNLHTLKFYCLPDNYEI-IDSSLEDITYVLKPTFTKQQIANLDKQAKL------ 211
H++ +NL T + +C E+ ++ L F++Q K
Sbjct: 68 KKHNLTVNLTTFRLWCYACEKEVFLEQRLAAPLLGSSSKFSEQDSPPPSHPLKAVPIAVA 127
Query: 212 ----SRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPG 267
S + D G+ G+ N+ + Y NA LQALSN PPL +FLE + P
Sbjct: 128 DEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPA 187
Query: 268 DIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFL 327
L + + +L+ ++W+ + ++V P + + L + F+ Q D +FL +
Sbjct: 188 -----LCKSYQKLVSEVWHKKR-PSYVVPTSLSHGIKLVN-PMFRGYAQQDTQEFLRCLM 240
Query: 328 NALHSAL 334
+ LH L
Sbjct: 241 DQLHEEL 247
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 66.6 bits (161), Expect = 6e-11
Identities = 79/358 (22%), Positives = 146/358 (40%), Gaps = 38/358 (10%)
Query: 223 GIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMR 282
G VGL N+ + NAVLQ LS+ PLR++ L D + + P G L + F +++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV--PGGGRAQELTEAFADVIG 267
Query: 283 KLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKK 342
LW+P + +A V+P +AV +F Q D +FL + LH + ++
Sbjct: 268 ALWHPDSCEA-VNP-TRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAP 325
Query: 343 TIVTD-VFQGSMRIFTKKLPHPDLPAEEKEQLLHND--EYQETMV--------------- 384
I+ + R L P+L +++ L+ E +++ +
Sbjct: 326 PILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQ 385
Query: 385 ----ESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKT-----YKE 435
ST + DL + P+ K + FN+ K + + K
Sbjct: 386 ACGYRSTTFEVFCDL-SLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
K+ + + P L+ + RF+ + ++K+ V+FP+ + L ++ S++ +
Sbjct: 445 RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKA----GSP 500
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWK 553
Y L A H G G Y + TG W+ D +V+ + + SE Y+ ++
Sbjct: 501 VYQLYALCNHSGSVHYGHYTA-LCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFYQ 556
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 66.6 bits (161), Expect = 6e-11
Identities = 79/358 (22%), Positives = 146/358 (40%), Gaps = 38/358 (10%)
Query: 223 GIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMR 282
G VGL N+ + NAVLQ LS+ PLR++ L D + + P G L + F +++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV--PGGGRAQELTEAFADVIG 267
Query: 283 KLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKK 342
LW+P + +A V+P +AV +F Q D +FL + LH + ++
Sbjct: 268 ALWHPDSCEA-VNP-TRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAP 325
Query: 343 TIVTD-VFQGSMRIFTKKLPHPDLPAEEKEQLLHND--EYQETMV--------------- 384
I+ + R L P+L +++ L+ E +++ +
Sbjct: 326 PILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQ 385
Query: 385 ----ESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKT-----YKE 435
ST + DL + P+ K + FN+ K + + K
Sbjct: 386 ACGYRSTTFEVFCDL-SLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
Query: 436 NFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT 495
K+ + + P L+ + RF+ + ++K+ V+FP+ + L ++ S++ +
Sbjct: 445 RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKA----GSP 500
Query: 496 TYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWK 553
Y L A H G G Y + TG W+ D +V+ + + SE Y+ ++
Sbjct: 501 VYQLYALCNHSGSVHYGHYTA-LCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFYQ 556
>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
Length = 1316
Score = 66.2 bits (160), Expect = 7e-11
Identities = 84/340 (24%), Positives = 140/340 (41%), Gaps = 51/340 (15%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ +ANA LQ L+ PPL NY L ++ K G M +Q + + L
Sbjct: 112 GLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTC-HAEGFCMMCTMQ--AHITQALS 168
Query: 286 NPRN-FKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK---- 339
NP + K +EM + + F+ Q D +FL + ++A+ A L G+ K
Sbjct: 169 NPGDVIKPMFVINEMRRIA-----RHFRFGNQEDAHEFLQYTVDAMQKACLNGSNKLDRH 223
Query: 340 -KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTA 398
+ T+V +F G +R + + L+ +T ++ +TL++ A
Sbjct: 224 TQATTLVCQIFGGYLR--------------SRVKCLNCKGVSDTF--DPYLDITLEIKAA 267
Query: 399 PLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFL----KRFQLTKLPPYLIFCI 454
EQ + P+ + +G E YK K + KRF + + L +
Sbjct: 268 QSVNKALEQFVKPE--------QLDG--ENSYKCSKCKKMVPASKRFTIHRSSNVLTLSL 317
Query: 455 KRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSY 514
KRF NF K V +P +D+R Y+S Q + Y L A +VH G +
Sbjct: 318 KRFA--NFTGGKIAKDVKYP-EYLDIRPYMS---QPNGEPIVYVLYAVLVHTGFNCHAGH 371
Query: 515 RIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKR 554
+ G WY++ D V+ + + +AY+ + R
Sbjct: 372 YFCYIKASNGLWYQMNDSIVSTSDIRSVLSQQAYVLFYIR 411
>gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo
sapiens]
Length = 530
Score = 65.9 bits (159), Expect = 1e-10
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S++ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQQ------NTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo
sapiens]
Length = 530
Score = 65.9 bits (159), Expect = 1e-10
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHPS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S++ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQQ------NTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 65.5 bits (158), Expect = 1e-10
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQADHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S++ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQQ------NTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 65.5 bits (158), Expect = 1e-10
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S++ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQQ------NTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo
sapiens]
Length = 530
Score = 65.5 bits (158), Expect = 1e-10
Identities = 86/352 (24%), Positives = 142/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S++ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQQ------NTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|239742285 PREDICTED: hypothetical protein XP_002342486 [Homo
sapiens]
Length = 559
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/349 (24%), Positives = 140/349 (40%), Gaps = 57/349 (16%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSY 514
RF+ ++KN V +P +D++ Y+S Q Y L A +VH G +
Sbjct: 282 RFSDVTGNKIDKN---VQYP-ECLDMKLYMS---QTNSGPLVYVLYAVLVHAGWSCHNGH 334
Query: 515 RIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 335 YFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 65.5 bits (158), Expect = 1e-10
Identities = 37/118 (31%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 439 KRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYD 498
K+ L LPP L+ +KRF+ + + +K T+V+FPI ++D+ E+L + Y+
Sbjct: 791 KKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDFPINDLDMSEFL---INPNAGPCRYN 847
Query: 499 LIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRD 556
LIA H G G Y + GKWY D V+ I AY+ ++R+D
Sbjct: 848 LIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 905
Score = 55.8 bits (133), Expect = 1e-07
Identities = 55/228 (24%), Positives = 94/228 (41%), Gaps = 50/228 (21%)
Query: 222 PGIVGLNNIKANDYANAVLQALSNVPPLRNYFL-----EEDNYKNIKRPPGDIMFLLVQR 276
PG+ GL+N+ + N+ +Q LSN PPL YFL EE N+ N G+I +
Sbjct: 257 PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEI----AKS 312
Query: 277 FGELMRKLWN-------PRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNA 329
+ EL++++W+ PR FK V F +Q D + L++ L+
Sbjct: 313 YAELIKQMWSGKFSYVTPRAFKTQVGRF----------APQFSGYQQQDCQELLAFLLDG 362
Query: 330 LHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEE-----------KEQLLHNDE 378
LH L +KK + D ++ ++ L + K L+ +
Sbjct: 363 LHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPEC 422
Query: 379 YQETMVESTFMYLTLDLPTA-------------PLYKDEKEQLIIPQV 413
+ ++ F YLTL LP PL K + ++++P++
Sbjct: 423 AKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKI 470
>gi|239742295 PREDICTED: hypothetical protein XP_002342479 [Homo
sapiens]
Length = 530
Score = 64.7 bits (156), Expect = 2e-10
Identities = 86/352 (24%), Positives = 141/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKMLTLLTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S+ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQ------PNTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|239742280 PREDICTED: hypothetical protein XP_002342473 [Homo
sapiens]
Length = 530
Score = 64.7 bits (156), Expect = 2e-10
Identities = 86/352 (24%), Positives = 141/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKMLTLLTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S+ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQ------PNTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
>gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/352 (24%), Positives = 141/352 (40%), Gaps = 63/352 (17%)
Query: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285
GL N+ Y NA LQ L+ PPL NY L ++ + R G +L + R L
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKG---CMLCTMQAHITRALH 137
Query: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSA-LGGTKK----- 339
NP + + P + L A F KQ D +FL + ++A+ A L G K+
Sbjct: 138 NPGHV---IQPSQALAA-------GFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHS 187
Query: 340 KKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP 399
K T++ +F G R + + LH +T ++ + LD+ A
Sbjct: 188 KDTTLIHQIFGGYWR--------------SQIKCLHCHGISDTF--DPYLDIALDIQAAQ 231
Query: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYK----TYKENFLKRFQLTKLPPYLIFCIK 455
+ EQL+ P+ + NG E Y + K L LI +K
Sbjct: 232 SVQQALEQLVKPE--------ELNG--ENAYHCGVCLQRAPASKTLTLHTSAKVLILVLK 281
Query: 456 RFTK-NNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNT---TYDLIANIVHDGKPSE 511
RF+ + KN V +P +D++ Y+S+ NT Y L A +VH G
Sbjct: 282 RFSDVTGNKIAKN---VQYP-ECLDMQPYMSQ------PNTGPLVYVLYAVLVHAGWSCH 331
Query: 512 GSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQ 563
+ + G+WY++ D +VT + +AY+ + ++ E + +
Sbjct: 332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSE 383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,347,835
Number of Sequences: 37866
Number of extensions: 1065318
Number of successful extensions: 5682
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 162
Number of HSP's that attempted gapping in prelim test: 4522
Number of HSP's gapped (non-prelim): 813
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.