Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 134304838
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134304838 eukaryotic translation initiation factor 2-alpha
kinase 3 [Homo sapiens]
(1116 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134304838 eukaryotic translation initiation factor 2-alpha ki... 2248 0.0
gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 171 3e-42
gi|197245437 eukaryotic translation initiation factor 2-alpha ki... 134 4e-31
gi|11125768 eukaryotic translation initiation factor 2-alpha kin... 134 4e-31
gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 131 3e-30
gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 131 3e-30
gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 131 3e-30
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 95 4e-19
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 93 1e-18
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 93 1e-18
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 91 6e-18
gi|21359873 polo-like kinase 1 [Homo sapiens] 87 9e-17
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 86 2e-16
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 83 2e-15
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 81 6e-15
gi|41872374 polo-like kinase 3 [Homo sapiens] 80 8e-15
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 79 2e-14
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 77 9e-14
gi|93004081 polo-like kinase 2 [Homo sapiens] 77 1e-13
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 75 3e-13
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 75 5e-13
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 75 5e-13
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 75 5e-13
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 74 6e-13
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 74 1e-12
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 74 1e-12
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 74 1e-12
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 74 1e-12
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 74 1e-12
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 73 1e-12
>gi|134304838 eukaryotic translation initiation factor 2-alpha kinase
3 [Homo sapiens]
Length = 1116
Score = 2248 bits (5825), Expect = 0.0
Identities = 1116/1116 (100%), Positives = 1116/1116 (100%)
Query: 1 MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP 60
MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
Sbjct: 1 MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP 60
Query: 61 AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP 120
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
Sbjct: 61 AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP 120
Query: 121 ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES 180
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
Sbjct: 121 ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES 180
Query: 181 LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR 240
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
Sbjct: 181 LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR 240
Query: 241 TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE 300
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
Sbjct: 241 TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE 300
Query: 301 QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS 360
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
Sbjct: 301 QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS 360
Query: 361 YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE 420
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
Sbjct: 361 YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE 420
Query: 421 NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY 480
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
Sbjct: 421 NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY 480
Query: 481 YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV 540
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
Sbjct: 481 YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV 540
Query: 541 RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG 600
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
Sbjct: 541 RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG 600
Query: 601 RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE 660
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
Sbjct: 601 RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE 660
Query: 661 APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR 720
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
Sbjct: 661 APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR 720
Query: 721 SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND 780
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
Sbjct: 721 SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND 780
Query: 781 EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF 840
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
Sbjct: 781 EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF 840
Query: 841 KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM 900
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
Sbjct: 841 KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM 900
Query: 901 NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT 960
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
Sbjct: 901 NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT 960
Query: 961 AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP 1020
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
Sbjct: 961 AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP 1020
Query: 1021 FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 1080
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
Sbjct: 1021 FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 1080
Query: 1081 DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN 1116
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
Sbjct: 1081 DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN 1116
>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4
[Homo sapiens]
Length = 1649
Score = 171 bits (434), Expect = 3e-42
Identities = 147/505 (29%), Positives = 219/505 (43%), Gaps = 107/505 (21%)
Query: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKL 646
SRY +FE +Q LG+G FG V + +NK+D C YA+KRI + ++ EV L++L
Sbjct: 584 SRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRL 643
Query: 647 EHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATK 706
H IVRY+NAW+E T P S P D + + +
Sbjct: 644 HHENIVRYYNAWIERHERP----------AGPGTPPPDSGPLAKDDRAARGQPASDTDGL 693
Query: 707 EHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCL 766
+ +E AP P S S S ++++S+ +F D ED E Q S L
Sbjct: 694 DSVEAAAPPPILSSSVEWSTSGERSASA--RFPATGPGSSDDEDDDEDEHGGVFSQ-SFL 750
Query: 767 TDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNR 826
D E + N++ E + S ED N + EP
Sbjct: 751 PASDSESDIIFDNED------------------ENSKSQNQDEDCNEKNGCHESEPSV-- 790
Query: 827 LHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYI 886
TTE + YLYI
Sbjct: 791 --------------------------------------------TTEAVH------YLYI 800
Query: 887 QMQLCRKENLKDWMNGRCTIEE---RERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
QM+ C K L+D TI++ R+ +F +I + + ++H KG++HRDLKP NI
Sbjct: 801 QMEYCEKSTLRD------TIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNI 854
Query: 944 FFTMDDVVKVGDFGLVT-----AMDQDEEEQT-VLTPMPAYARHTGQVGTKLYMSPEQIH 997
F DD VK+GDFGL T + D +++QT L TG VGT LY+SPE +
Sbjct: 855 FLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPE-VQ 913
Query: 998 G---NSYSHKVDIFSLGLILFELLY-PFSTQMERVRTLTDVR---NLKFPPLFTQ-KYPC 1049
G ++Y+ KVD+FSLG+I FE+ Y P T ER+ L +R + KFP F ++
Sbjct: 914 GSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAK 973
Query: 1050 EYVMVQDMLSPSPMERPEAINIIEN 1074
+ ++ +L+ P +RP A ++++
Sbjct: 974 QKSVISWLLNHDPAKRPTATELLKS 998
Score = 32.7 bits (73), Expect = 2.0
Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 4/55 (7%)
Query: 920 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFG----LVTAMDQDEEEQT 970
Q+ +++LHS ++H+ L SN+ + VK+ D+ L +D EQT
Sbjct: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT 462
>gi|197245437 eukaryotic translation initiation factor 2-alpha kinase
1 isoform b [Homo sapiens]
Length = 629
Score = 134 bits (338), Expect = 4e-31
Identities = 96/324 (29%), Positives = 151/324 (46%), Gaps = 32/324 (9%)
Query: 779 NDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLT 838
NDE S + +E +P R F +S +N ++K T L I + T
Sbjct: 270 NDESSSSSIIFAEPTPEKEKR--------FGESDTENQNNKSVKYTTNLVIRESGELEST 321
Query: 839 AFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV------------YLYI 886
+ + A+ + P + L ++ T + S V L+I
Sbjct: 322 LELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHI 381
Query: 887 QMQLCRKENLKDWM-----NGRCTIEERE-----RSVCLHIFLQIAEAVEFLHSKGLMHR 936
QMQLC +L DW+ GR ++E +V IF ++ E V ++H+ G++HR
Sbjct: 382 QMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHR 440
Query: 937 DLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQ 995
DLKP NIF D VK+GDFGL + HT +VGT LY SPEQ
Sbjct: 441 DLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQ 500
Query: 996 IHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQ 1055
+ G+ Y K D++SLG++L EL PF T+MER LT +R + P ++ P + +Q
Sbjct: 501 LEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQ 560
Query: 1056 DMLSPSPMERPEAINIIENAVFED 1079
+ + +RP AI ++++ +F++
Sbjct: 561 HLTRRNSSQRPSAIQLLQSELFQN 584
Score = 74.7 bits (182), Expect = 5e-13
Identities = 37/75 (49%), Positives = 51/75 (68%), Gaps = 1/75 (1%)
Query: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAK 645
SRYL +FE + LG+GG+G V++ +NK+D YAIK+I + + KV+REVK LA
Sbjct: 161 SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220
Query: 646 LEHPGIVRYFNAWLE 660
L+HP IV Y AW+E
Sbjct: 221 LQHPNIVGYHTAWIE 235
>gi|11125768 eukaryotic translation initiation factor 2-alpha kinase 1
isoform a [Homo sapiens]
Length = 630
Score = 134 bits (338), Expect = 4e-31
Identities = 96/324 (29%), Positives = 151/324 (46%), Gaps = 32/324 (9%)
Query: 779 NDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLT 838
NDE S + +E +P R F +S +N ++K T L I + T
Sbjct: 271 NDESSSSSIIFAEPTPEKEKR--------FGESDTENQNNKSVKYTTNLVIRESGELEST 322
Query: 839 AFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV------------YLYI 886
+ + A+ + P + L ++ T + S V L+I
Sbjct: 323 LELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHI 382
Query: 887 QMQLCRKENLKDWM-----NGRCTIEERE-----RSVCLHIFLQIAEAVEFLHSKGLMHR 936
QMQLC +L DW+ GR ++E +V IF ++ E V ++H+ G++HR
Sbjct: 383 QMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHNMGIVHR 441
Query: 937 DLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQ 995
DLKP NIF D VK+GDFGL + HT +VGT LY SPEQ
Sbjct: 442 DLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQ 501
Query: 996 IHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQ 1055
+ G+ Y K D++SLG++L EL PF T+MER LT +R + P ++ P + +Q
Sbjct: 502 LEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQ 561
Query: 1056 DMLSPSPMERPEAINIIENAVFED 1079
+ + +RP AI ++++ +F++
Sbjct: 562 HLTRRNSSQRPSAIQLLQSELFQN 585
Score = 74.7 bits (182), Expect = 5e-13
Identities = 37/75 (49%), Positives = 51/75 (68%), Gaps = 1/75 (1%)
Query: 587 SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAK 645
SRYL +FE + LG+GG+G V++ +NK+D YAIK+I + + KV+REVK LA
Sbjct: 161 SRYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAG 220
Query: 646 LEHPGIVRYFNAWLE 660
L+HP IV Y AW+E
Sbjct: 221 LQHPNIVGYHTAWIE 235
>gi|208431829 eukaryotic translation initiation factor 2-alpha kinase
2 isoform b [Homo sapiens]
Length = 510
Score = 131 bits (330), Expect = 3e-30
Identities = 75/189 (39%), Positives = 108/189 (57%), Gaps = 17/189 (8%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L+IQM+ C K L+ W+ R E+ ++ + L +F QI + V+++HSK L+HRDLKPSNI
Sbjct: 321 LFIQMEFCDKGTLEQWIEKRRG-EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
F VK+GDFGLVT++ D + T GT YMSPEQI Y
Sbjct: 380 FLVDTKQVKIGDFGLVTSLKND-------------GKRTRSKGTLRYMSPEQISSQDYGK 426
Query: 1004 KVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPM 1063
+VD+++LGLIL ELL+ T E + TD+R+ +F +K E ++Q +LS P
Sbjct: 427 EVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPE 483
Query: 1064 ERPEAINII 1072
+RP I+
Sbjct: 484 DRPNTSEIL 492
Score = 33.9 bits (76), Expect = 0.88
Identities = 15/26 (57%), Positives = 17/26 (65%)
Query: 633 REKVMREVKALAKLEHPGIVRYFNAW 658
+ K REVKALAKL+H IV Y W
Sbjct: 261 KRKAEREVKALAKLDHVNIVHYNGCW 286
>gi|208431827 eukaryotic translation initiation factor 2-alpha kinase
2 isoform a [Homo sapiens]
Length = 551
Score = 131 bits (330), Expect = 3e-30
Identities = 75/189 (39%), Positives = 108/189 (57%), Gaps = 17/189 (8%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L+IQM+ C K L+ W+ R E+ ++ + L +F QI + V+++HSK L+HRDLKPSNI
Sbjct: 362 LFIQMEFCDKGTLEQWIEKRRG-EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
F VK+GDFGLVT++ D + T GT YMSPEQI Y
Sbjct: 421 FLVDTKQVKIGDFGLVTSLKND-------------GKRTRSKGTLRYMSPEQISSQDYGK 467
Query: 1004 KVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPM 1063
+VD+++LGLIL ELL+ T E + TD+R+ +F +K E ++Q +LS P
Sbjct: 468 EVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPE 524
Query: 1064 ERPEAINII 1072
+RP I+
Sbjct: 525 DRPNTSEIL 533
Score = 71.2 bits (173), Expect = 5e-12
Identities = 38/82 (46%), Positives = 51/82 (62%), Gaps = 7/82 (8%)
Query: 579 DIKNSGYI--SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV 636
D+K + Y R+ DF+ I+ +G GGFG VF+AK+++D Y IKR++ N EK
Sbjct: 251 DMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKA 305
Query: 637 MREVKALAKLEHPGIVRYFNAW 658
REVKALAKL+H IV Y W
Sbjct: 306 EREVKALAKLDHVNIVHYNGCW 327
>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase 2
isoform a [Homo sapiens]
Length = 551
Score = 131 bits (330), Expect = 3e-30
Identities = 75/189 (39%), Positives = 108/189 (57%), Gaps = 17/189 (8%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L+IQM+ C K L+ W+ R E+ ++ + L +F QI + V+++HSK L+HRDLKPSNI
Sbjct: 362 LFIQMEFCDKGTLEQWIEKRRG-EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
F VK+GDFGLVT++ D + T GT YMSPEQI Y
Sbjct: 421 FLVDTKQVKIGDFGLVTSLKND-------------GKRTRSKGTLRYMSPEQISSQDYGK 467
Query: 1004 KVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPM 1063
+VD+++LGLIL ELL+ T E + TD+R+ +F +K E ++Q +LS P
Sbjct: 468 EVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPE 524
Query: 1064 ERPEAINII 1072
+RP I+
Sbjct: 525 DRPNTSEIL 533
Score = 71.2 bits (173), Expect = 5e-12
Identities = 38/82 (46%), Positives = 51/82 (62%), Gaps = 7/82 (8%)
Query: 579 DIKNSGYI--SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV 636
D+K + Y R+ DF+ I+ +G GGFG VF+AK+++D Y IKR++ N EK
Sbjct: 251 DMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKA 305
Query: 637 MREVKALAKLEHPGIVRYFNAW 658
REVKALAKL+H IV Y W
Sbjct: 306 EREVKALAKLDHVNIVHYNGCW 327
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 94.7 bits (234), Expect = 4e-19
Identities = 62/171 (36%), Positives = 92/171 (53%), Gaps = 18/171 (10%)
Query: 910 ERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQ 969
ER+V + F+Q+ A+E +HS+ +MHRD+KP+N+F T VVK+GD GL
Sbjct: 135 ERTVWKY-FVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSS----- 188
Query: 970 TVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFE---LLYPF-STQM 1025
A H+ VGT YMSPE+IH N Y+ K DI+SLG +L+E L PF +M
Sbjct: 189 ------KTTAAHS-LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM 241
Query: 1026 ERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDM-LSPSPMERPEAINIIENA 1075
+ +PPL + Y E + +M ++P P +RP+ + + A
Sbjct: 242 NLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVA 292
Score = 40.0 bits (92), Expect = 0.012
Identities = 20/73 (27%), Positives = 42/73 (57%), Gaps = 2/73 (2%)
Query: 590 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR--ELAREKVMREVKALAKLE 647
L +F + +GRG F V+ A +D A+K++++ + AR ++E+ L +L
Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90
Query: 648 HPGIVRYFNAWLE 660
HP +++Y+ +++E
Sbjct: 91 HPNVIKYYASFIE 103
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/163 (37%), Positives = 88/163 (53%), Gaps = 18/163 (11%)
Query: 910 ERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQ 969
ER+V + F+Q+ AVE +HS+ +MHRD+KP+N+F T VVK+GD GL +
Sbjct: 180 ERTVWKY-FVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSE---- 234
Query: 970 TVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFE---LLYPF-STQM 1025
A H+ VGT YMSPE+IH N Y+ K DI+SLG +L+E L PF +M
Sbjct: 235 -------TTAAHS-LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM 286
Query: 1026 ERVRTLTDVRNLKFPPLFTQKYPCEY-VMVQDMLSPSPMERPE 1067
+ +PPL + Y + +V + P P +RP+
Sbjct: 287 NLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPD 329
Score = 43.9 bits (102), Expect = 9e-04
Identities = 22/73 (30%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 590 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR--ELAREKVMREVKALAKLE 647
L DF+ + +GRG F V++A +D A+K++++ AR+ ++E+ L +L
Sbjct: 76 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 135
Query: 648 HPGIVRYFNAWLE 660
HP I++Y ++++E
Sbjct: 136 HPNIIKYLDSFIE 148
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/163 (37%), Positives = 88/163 (53%), Gaps = 18/163 (11%)
Query: 910 ERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQ 969
ER+V + F+Q+ AVE +HS+ +MHRD+KP+N+F T VVK+GD GL +
Sbjct: 146 ERTVWKY-FVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSE---- 200
Query: 970 TVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFE---LLYPF-STQM 1025
A H+ VGT YMSPE+IH N Y+ K DI+SLG +L+E L PF +M
Sbjct: 201 -------TTAAHS-LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM 252
Query: 1026 ERVRTLTDVRNLKFPPLFTQKYPCEY-VMVQDMLSPSPMERPE 1067
+ +PPL + Y + +V + P P +RP+
Sbjct: 253 NLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPD 295
Score = 43.9 bits (102), Expect = 9e-04
Identities = 22/73 (30%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
Query: 590 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR--ELAREKVMREVKALAKLE 647
L DF+ + +GRG F V++A +D A+K++++ AR+ ++E+ L +L
Sbjct: 42 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 101
Query: 648 HPGIVRYFNAWLE 660
HP I++Y ++++E
Sbjct: 102 HPNIIKYLDSFIE 114
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 90.9 bits (224), Expect = 6e-18
Identities = 68/240 (28%), Positives = 115/240 (47%), Gaps = 34/240 (14%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L I+++ C NL D + + E V ++F QI AV +H G++HRD+K NI
Sbjct: 124 LLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLF-QIVSAVSCIHKAGILHRDIKTLNI 182
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
F T +++K+GD+GL ++ + Y+ VGT YMSPE G Y+
Sbjct: 183 FLTKANLIKLGDYGLAKKLNSE------------YSMAETLVGTPYYMSPELCQGVKYNF 230
Query: 1004 KVDIFSLGLILFELL---YPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYV-MVQDMLS 1059
K DI+++G ++FELL F + V+ ++ + + +Y E + MV L
Sbjct: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
Query: 1060 PSPMERPEAINIIENAVFEDLDFPGKTVLRQRSR------SLSSSGTKHSRQSNNSHSPL 1113
P +RP A +++ + +LR+R R +L ++ TK R S + +P+
Sbjct: 291 QDPEQRPTADELLD-----------RPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPI 339
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/115 (28%), Positives = 49/115 (42%), Gaps = 8/115 (6%)
Query: 554 ESETQCQTENK-YDSVSGEANDSSWNDIKNSG------YISRYLTDFEPIQCLGRGGFGV 606
E E C + N + S SG DSS + G + + PI+ LGRG FG
Sbjct: 6 EYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGRGAFGE 65
Query: 607 VFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEHPGIVRYFNAWLE 660
+ DD K + L E R + E+ LA L+H I+ Y+N +++
Sbjct: 66 ATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD 120
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 87.0 bits (214), Expect = 9e-17
Identities = 59/206 (28%), Positives = 96/206 (46%), Gaps = 20/206 (9%)
Query: 883 YLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSN 942
++++ ++LCR+ +L + R + E E L QI ++LH ++HRDLK N
Sbjct: 125 FVFVVLELCRRRSLLELHKRRKALTEPEARYYLR---QIVLGCQYLHRNRVIHRDLKLGN 181
Query: 943 IFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYS 1002
+F D VK+GDFGL T ++ D E + L GT Y++PE + +S
Sbjct: 182 LFLNEDLEVKIGDFGLATKVEYDGERKKTL------------CGTPNYIAPEVLSKKGHS 229
Query: 1003 HKVDIFSLGLILFELLY---PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLS 1059
+VD++S+G I++ LL PF T + L +N P P ++Q ML
Sbjct: 230 FEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHIN--PVAASLIQKMLQ 287
Query: 1060 PSPMERPEAINIIENAVFEDLDFPGK 1085
P RP ++ + F P +
Sbjct: 288 TDPTARPTINELLNDEFFTSGYIPAR 313
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 85.9 bits (211), Expect = 2e-16
Identities = 49/162 (30%), Positives = 83/162 (51%), Gaps = 24/162 (14%)
Query: 918 FLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 977
F+QIA A+++LH K ++HRDLK N+F T +++KVGD G+ ++ + + L
Sbjct: 112 FVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTL----- 166
Query: 978 YARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNL 1037
+GT YMSPE Y++K D+++LG ++E+ ++ D+ +L
Sbjct: 167 -------IGTPYYMSPELFSNKPYNYKSDVWALGCCVYEM-----ATLKHAFNAKDMNSL 214
Query: 1038 -------KFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINII 1072
K PP+ P +++ MLS P ERP +I+
Sbjct: 215 VYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSIL 256
Score = 42.7 bits (99), Expect = 0.002
Identities = 21/64 (32%), Positives = 36/64 (56%), Gaps = 1/64 (1%)
Query: 596 IQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEHPGIVRY 654
++ +G+G +G V K++ D Y IK++ L N R +E + L++L+HP IV Y
Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68
Query: 655 FNAW 658
+W
Sbjct: 69 KESW 72
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 82.8 bits (203), Expect = 2e-15
Identities = 64/210 (30%), Positives = 96/210 (45%), Gaps = 30/210 (14%)
Query: 884 LYIQMQLCRKENLKDWMN-GRCTIEERERSVCLHIFLQIAEAVEFLHSKG-----LMHRD 937
LYI M+ C +L + G + + L + Q+ A++ H + ++HRD
Sbjct: 82 LYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRD 141
Query: 938 LKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIH 997
LKP+N+F VK+GDFGL ++ D VGT YMSPEQ++
Sbjct: 142 LKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF------------VGTPYYMSPEQMN 189
Query: 998 GNSYSHKVDIFSLGLILFEL--LYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEY---- 1051
SY+ K DI+SLG +L+EL L P T + +R KF ++ P Y
Sbjct: 190 RMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKF-----RRIPYRYSDEL 244
Query: 1052 -VMVQDMLSPSPMERPEAINIIENAVFEDL 1080
++ ML+ RP I+EN + DL
Sbjct: 245 NEIITRMLNLKDYHRPSVEEILENPLIADL 274
Score = 35.4 bits (80), Expect = 0.30
Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 1/66 (1%)
Query: 592 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEHPG 650
D+E + +G G +G + + K D K + + E ++ ++ EV L +L+HP
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
Query: 651 IVRYFN 656
IVRY++
Sbjct: 67 IVRYYD 72
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 80.9 bits (198), Expect = 6e-15
Identities = 55/193 (28%), Positives = 92/193 (47%), Gaps = 17/193 (8%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
LYI M C +L +N + + +E + L F+QI A++ +H + ++HRD+K NI
Sbjct: 76 LYIVMDYCEGGDLFKRINAQKGVLFQEDQI-LDWFVQICLALKHVHDRKILHRDIKSQNI 134
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
F T D V++GDFG+ ++ E +GT Y+SPE Y++
Sbjct: 135 FLTKDGTVQLGDFGIARVLNSTVELARTC------------IGTPYYLSPEICENKPYNN 182
Query: 1004 KVDIFSLGLILFELL---YPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSP 1060
K DI++LG +L+EL + F + L + FPP+ +V +
Sbjct: 183 KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG-SFPPVSLHYSYDLRSLVSQLFKR 241
Query: 1061 SPMERPEAINIIE 1073
+P +RP +I+E
Sbjct: 242 NPRDRPSVNSILE 254
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/68 (38%), Positives = 38/68 (55%), Gaps = 5/68 (7%)
Query: 596 IQCLGRGGFGVVFEAKNKVDDCNYAIKRI---RLPNRELAREKVMREVKALAKLEHPGIV 652
+Q +G G FG K+ D Y IK I R+ ++E RE+ REV LA ++HP IV
Sbjct: 7 LQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKE--REESRREVAVLANMKHPNIV 64
Query: 653 RYFNAWLE 660
+Y ++ E
Sbjct: 65 QYRESFEE 72
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 80.5 bits (197), Expect = 8e-15
Identities = 54/197 (27%), Positives = 96/197 (48%), Gaps = 20/197 (10%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
+YI ++LC +++L R T+ E E L QI +++LH +G++HRDLK N
Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYYLR---QILSGLKYLHQRGILHRDLKLGNF 191
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
F T + +KVGDFGL ++ E+ + + GT Y++PE + +
Sbjct: 192 FITENMELKVGDFGLAARLEPPEQRKKTI------------CGTPNYVAPEVLLRQGHGP 239
Query: 1004 KVDIFSLGLILFELLY---PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSP 1060
+ D++SLG +++ LL PF T + T ++ + + + P ++ +L
Sbjct: 240 EADVWSLGCVMYTLLCGSPPFET-ADLKETYRCIKQVHYTLPASLSLPARQLLAA-ILRA 297
Query: 1061 SPMERPEAINIIENAVF 1077
SP +RP I+ + F
Sbjct: 298 SPRDRPSIDQILRHDFF 314
Score = 36.6 bits (83), Expect = 0.14
Identities = 22/68 (32%), Positives = 38/68 (55%), Gaps = 8/68 (11%)
Query: 599 LGRGGFGVVFEAKNKVDDCNYAIK-----RIRLPNRELAREKVMREVKALAKLEHPGIVR 653
LG+GGF +EA + YA+K R+ P++ REK++ E++ L+H IVR
Sbjct: 68 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQ---REKILNEIELHRDLQHRHIVR 124
Query: 654 YFNAWLEA 661
+ + + +A
Sbjct: 125 FSHHFEDA 132
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 79.0 bits (193), Expect = 2e-14
Identities = 64/225 (28%), Positives = 102/225 (45%), Gaps = 22/225 (9%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L I M+ L +++ RC E ++ LH F+QI A+ +H+ ++HRDLK NI
Sbjct: 76 LMIAMEYAPGGTLAEFIQKRCNSLLEEETI-LHFFVQILLALHHVHTHLILHRDLKTQNI 134
Query: 944 FFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYS 1002
VVK+GDFG+ + + TV VGT Y+SPE G Y+
Sbjct: 135 LLDKHRMVVKIGDFGISKILSSKSKAYTV-------------VGTPCYISPELCEGKPYN 181
Query: 1003 HKVDIFSLGLILFEL--LYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSP 1060
K DI++LG +L+EL L + + + F P+ + P +V +LS
Sbjct: 182 QKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSL 241
Query: 1061 SPMERPEAINIIE-----NAVFEDLDFPGKTVLRQRSRSLSSSGT 1100
P +RP +I+ A+ G +R+ +S++ S T
Sbjct: 242 EPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNT 286
Score = 41.6 bits (96), Expect = 0.004
Identities = 23/71 (32%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 593 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREK---VMREVKALAKLEHP 649
+E I+ +GRG FG+V K D IK+I P ++ +E+ E + L L HP
Sbjct: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQI--PVEQMTKEERQAAQNECQVLKLLNHP 61
Query: 650 GIVRYFNAWLE 660
++ Y+ +LE
Sbjct: 62 NVIEYYENFLE 72
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 77.0 bits (188), Expect = 9e-14
Identities = 54/203 (26%), Positives = 100/203 (49%), Gaps = 22/203 (10%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L+I M+ C +L +N + + E + L F+QI+ ++ +H + ++HRD+K NI
Sbjct: 76 LFIVMEYCDGGDLMKRINRQRGVLFSEDQI-LGWFVQISLGLKHIHDRKILHRDIKAQNI 134
Query: 944 FFTMDDVV-KVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYS 1002
F + + +V K+GDFG+ ++ E +GT Y+SPE Y+
Sbjct: 135 FLSKNGMVAKLGDFGIARVLNNSMELARTC------------IGTPYYLSPEICQNKPYN 182
Query: 1003 HKVDIFSLGLILFELL---YPF--STQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDM 1057
+K DI+SLG +L+EL +PF + + V + P F+++ + ++ +
Sbjct: 183 NKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSREL---HSLISQL 239
Query: 1058 LSPSPMERPEAINIIENAVFEDL 1080
SP +RP +I++ E+L
Sbjct: 240 FQVSPRDRPSINSILKRPFLENL 262
Score = 47.0 bits (110), Expect = 1e-04
Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 593 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRI---RLPNRELAREKVMREVKALAKLEHP 649
++ I+ +G+G FG + AK K D + IK I ++P +E +E +EV L K++HP
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQE--KEASKKEVILLEKMKHP 61
Query: 650 GIVRYFNAWLE 660
IV +FN++ E
Sbjct: 62 NIVAFFNSFQE 72
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/200 (26%), Positives = 96/200 (48%), Gaps = 20/200 (10%)
Query: 881 KVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKP 940
K +YI ++ C + ++ + R + E E L QI +++LH + ++HRDLK
Sbjct: 152 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLR---QIVSGLKYLHEQEILHRDLKL 208
Query: 941 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS 1000
N F +KVGDFGL ++ E + + GT Y+SPE ++
Sbjct: 209 GNFFINEAMELKVGDFGLAARLEPLEHRRRTI------------CGTPNYLSPEVLNKQG 256
Query: 1001 YSHKVDIFSLGLILFELLY---PFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDM 1057
+ + DI++LG +++ +L PF T + T +R ++ + P ++ ++ M
Sbjct: 257 HGCESDIWALGCVMYTMLLGRPPFETTNLK-ETYRCIREARYTMPSSLLAPAKH-LIASM 314
Query: 1058 LSPSPMERPEAINIIENAVF 1077
LS +P +RP +II + F
Sbjct: 315 LSKNPEDRPSLDDIIRHDFF 334
Score = 31.6 bits (70), Expect = 4.4
Identities = 19/62 (30%), Positives = 35/62 (56%), Gaps = 6/62 (9%)
Query: 599 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA----REKVMREVKALAKLEHPGIVRY 654
LG+GGF +E + ++ YA K I P+ +A REK+ +E++ L H +V++
Sbjct: 88 LGKGGFAKCYEMTDLTNNKVYAAKII--PHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
Query: 655 FN 656
++
Sbjct: 146 YH 147
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 75.1 bits (183), Expect = 3e-13
Identities = 47/137 (34%), Positives = 71/137 (51%), Gaps = 17/137 (12%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
+ I M+ K L D+++ R + ERE H F QI AV + H G++HRDLK NI
Sbjct: 128 IVIIMEYASKGELYDYISERRRLSERETR---HFFRQIVSAVHYCHKNGVVHRDLKLENI 184
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSY-S 1002
+ +K+ DFGL +D+ QT G+ LY SPE ++G Y
Sbjct: 185 LLDDNCNIKIADFGLSNLYQKDKFLQTF-------------CGSPLYASPEIVNGRPYRG 231
Query: 1003 HKVDIFSLGLILFELLY 1019
+VD ++LG++L+ L+Y
Sbjct: 232 PEVDSWALGVLLYTLVY 248
Score = 30.8 bits (68), Expect = 7.5
Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 2/68 (2%)
Query: 593 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV--MREVKALAKLEHPG 650
+E + LG+G +G V A + AIK IR + ++ V RE++ ++ L HP
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 651 IVRYFNAW 658
I+ + +
Sbjct: 115 IISIYEVF 122
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 74.7 bits (182), Expect = 5e-13
Identities = 60/200 (30%), Positives = 94/200 (47%), Gaps = 23/200 (11%)
Query: 883 YLYIQMQLCRKENLKDWMN---GRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLK 939
+LYI M+ C +L + G+ E+ + L+ F Q+ V +H K ++HRD+K
Sbjct: 74 HLYIVMEYCDGGDLMQKIKQQKGKLFPED----MILNWFTQMCLGVNHIHKKRVLHRDIK 129
Query: 940 PSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGN 999
NIF T + VK+GDFG + + PM A+A VGT Y+ PE
Sbjct: 130 SKNIFLTQNGKVKLGDFG---------SARLLSNPM-AFA--CTYVGTPYYVPPEIWENL 177
Query: 1000 SYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQD 1056
Y++K DI+SLG IL+EL +PF + L + P Y ++ +V+
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQF-LVKQ 236
Query: 1057 MLSPSPMERPEAINIIENAV 1076
M +P RP A ++ +
Sbjct: 237 MFKRNPSHRPSATTLLSRGI 256
Score = 40.4 bits (93), Expect = 0.009
Identities = 19/65 (29%), Positives = 35/65 (53%)
Query: 590 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 649
+ D+ ++ +G G FG +++ + +A+K IRLP + +E LAK++HP
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 650 GIVRY 654
IV +
Sbjct: 61 NIVAF 65
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 74.7 bits (182), Expect = 5e-13
Identities = 60/200 (30%), Positives = 94/200 (47%), Gaps = 23/200 (11%)
Query: 883 YLYIQMQLCRKENLKDWMN---GRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLK 939
+LYI M+ C +L + G+ E+ + L+ F Q+ V +H K ++HRD+K
Sbjct: 74 HLYIVMEYCDGGDLMQKIKQQKGKLFPED----MILNWFTQMCLGVNHIHKKRVLHRDIK 129
Query: 940 PSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGN 999
NIF T + VK+GDFG + + PM A+A VGT Y+ PE
Sbjct: 130 SKNIFLTQNGKVKLGDFG---------SARLLSNPM-AFA--CTYVGTPYYVPPEIWENL 177
Query: 1000 SYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQD 1056
Y++K DI+SLG IL+EL +PF + L + P Y ++ +V+
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQF-LVKQ 236
Query: 1057 MLSPSPMERPEAINIIENAV 1076
M +P RP A ++ +
Sbjct: 237 MFKRNPSHRPSATTLLSRGI 256
Score = 40.4 bits (93), Expect = 0.009
Identities = 19/65 (29%), Positives = 35/65 (53%)
Query: 590 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 649
+ D+ ++ +G G FG +++ + +A+K IRLP + +E LAK++HP
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 650 GIVRY 654
IV +
Sbjct: 61 NIVAF 65
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 74.7 bits (182), Expect = 5e-13
Identities = 60/200 (30%), Positives = 94/200 (47%), Gaps = 23/200 (11%)
Query: 883 YLYIQMQLCRKENLKDWMN---GRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLK 939
+LYI M+ C +L + G+ E+ + L+ F Q+ V +H K ++HRD+K
Sbjct: 74 HLYIVMEYCDGGDLMQKIKQQKGKLFPED----MILNWFTQMCLGVNHIHKKRVLHRDIK 129
Query: 940 PSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGN 999
NIF T + VK+GDFG + + PM A+A VGT Y+ PE
Sbjct: 130 SKNIFLTQNGKVKLGDFG---------SARLLSNPM-AFA--CTYVGTPYYVPPEIWENL 177
Query: 1000 SYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQD 1056
Y++K DI+SLG IL+EL +PF + L + P Y ++ +V+
Sbjct: 178 PYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQF-LVKQ 236
Query: 1057 MLSPSPMERPEAINIIENAV 1076
M +P RP A ++ +
Sbjct: 237 MFKRNPSHRPSATTLLSRGI 256
Score = 40.4 bits (93), Expect = 0.009
Identities = 19/65 (29%), Positives = 35/65 (53%)
Query: 590 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 649
+ D+ ++ +G G FG +++ + +A+K IRLP + +E LAK++HP
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHP 60
Query: 650 GIVRY 654
IV +
Sbjct: 61 NIVAF 65
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 74.3 bits (181), Expect = 6e-13
Identities = 57/209 (27%), Positives = 98/209 (46%), Gaps = 17/209 (8%)
Query: 870 NTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLH 929
N T+ L + Y+ M+LC NL + + +EE E + Q+ AVE LH
Sbjct: 122 NITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIR---QLISAVEHLH 178
Query: 930 SKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKL 989
G++HRDLK N+ D+ +K+ DFGL +L ++ Q G+
Sbjct: 179 RAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAG-------ILGYSDPFST---QCGSPA 228
Query: 990 YMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMERVRTL-TDVRNLKFPPLFTQ 1045
Y +PE + Y K+D++S+G+ ++ +L PF+ + +R L + + + PL TQ
Sbjct: 229 YAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQ 288
Query: 1046 KYPCEYVMVQDMLSPSPMERPEAINIIEN 1074
++ +L P P++RP + N
Sbjct: 289 LSTGAISFLRSLLEPDPVKRPNIQQALAN 317
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 73.6 bits (179), Expect = 1e-12
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 25/144 (17%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
+++ M+ C +L D++ + T+ E V LH QIA A+ LHSKG++HRDLKP NI
Sbjct: 81 VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLH---QIAAAMRILHSKGIIHRDLKPQNI 137
Query: 944 FFTMDD---------VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPE 994
+ + +K+ DFG + + T+ G+ +YM+PE
Sbjct: 138 LLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATL-------------CGSPMYMAPE 184
Query: 995 QIHGNSYSHKVDIFSLGLILFELL 1018
I Y K D++S+G ++++ L
Sbjct: 185 VIMSQHYDAKADLWSIGTVIYQCL 208
Score = 34.3 bits (77), Expect = 0.68
Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 599 LGRGGFGVVFEAKNKVD-DCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFN 656
+G G F VVF +++ D AIK I N ++ + +E+K L +L+H IV ++
Sbjct: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYD 73
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 73.6 bits (179), Expect = 1e-12
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 25/144 (17%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
+++ M+ C +L D++ + T+ E V LH QIA A+ LHSKG++HRDLKP NI
Sbjct: 81 VFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLH---QIAAAMRILHSKGIIHRDLKPQNI 137
Query: 944 FFTMDD---------VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPE 994
+ + +K+ DFG + + T+ G+ +YM+PE
Sbjct: 138 LLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATL-------------CGSPMYMAPE 184
Query: 995 QIHGNSYSHKVDIFSLGLILFELL 1018
I Y K D++S+G ++++ L
Sbjct: 185 VIMSQHYDAKADLWSIGTVIYQCL 208
Score = 34.3 bits (77), Expect = 0.68
Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 599 LGRGGFGVVFEAKNKVD-DCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFN 656
+G G F VVF +++ D AIK I N ++ + +E+K L +L+H IV ++
Sbjct: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYD 73
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 73.6 bits (179), Expect = 1e-12
Identities = 42/135 (31%), Positives = 72/135 (53%), Gaps = 16/135 (11%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L++ M+ +L D + C E + +VC + +A+EFLHS ++HRD+K NI
Sbjct: 340 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR----ECLQALEFLHSNQVIHRDIKSDNI 395
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
MD VK+ DFG + ++ +++ + VGT +M+PE + +Y
Sbjct: 396 LLGMDGSVKLTDFGFCAQITPEQSKRSTM------------VGTPYWMAPEVVTRKAYGP 443
Query: 1004 KVDIFSLGLILFELL 1018
KVDI+SLG++ E++
Sbjct: 444 KVDIWSLGIMAIEMI 458
Score = 35.8 bits (81), Expect = 0.23
Identities = 28/116 (24%), Positives = 53/116 (45%), Gaps = 13/116 (11%)
Query: 560 QTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNY 619
+ + K +S E I + G + T FE I G+G G V+ A +
Sbjct: 240 EKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKI---GQGASGTVYTAMDVATGQEV 296
Query: 620 AIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWL 675
AIK++ L ++ +E ++ E+ + + ++P IV Y +++L DE+W+
Sbjct: 297 AIKQMNL-QQQPKKELIINEILVMRENKNPNIVNYLDSYLVG---------DELWV 342
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 73.6 bits (179), Expect = 1e-12
Identities = 42/135 (31%), Positives = 72/135 (53%), Gaps = 16/135 (11%)
Query: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
L++ M+ +L D + C E + +VC + +A+EFLHS ++HRD+K NI
Sbjct: 340 LWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR----ECLQALEFLHSNQVIHRDIKSDNI 395
Query: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
MD VK+ DFG + ++ +++ + VGT +M+PE + +Y
Sbjct: 396 LLGMDGSVKLTDFGFCAQITPEQSKRSTM------------VGTPYWMAPEVVTRKAYGP 443
Query: 1004 KVDIFSLGLILFELL 1018
KVDI+SLG++ E++
Sbjct: 444 KVDIWSLGIMAIEMI 458
Score = 35.8 bits (81), Expect = 0.23
Identities = 28/116 (24%), Positives = 53/116 (45%), Gaps = 13/116 (11%)
Query: 560 QTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNY 619
+ + K +S E I + G + T FE I G+G G V+ A +
Sbjct: 240 EKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKI---GQGASGTVYTAMDVATGQEV 296
Query: 620 AIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWL 675
AIK++ L ++ +E ++ E+ + + ++P IV Y +++L DE+W+
Sbjct: 297 AIKQMNL-QQQPKKELIINEILVMRENKNPNIVNYLDSYLVG---------DELWV 342
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 73.6 bits (179), Expect = 1e-12
Identities = 50/153 (32%), Positives = 78/153 (50%), Gaps = 19/153 (12%)
Query: 917 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 976
I Q+ A+ +LHS ++HRD+KP NI +K+ DFG AM + VLT +
Sbjct: 105 IAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTN---TMVLTSIK 161
Query: 977 AYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY---PF-STQMERVRTLT 1032
GT LYMSPE + Y H D++S+G IL+EL PF +T + ++ +L
Sbjct: 162 ---------GTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLI 212
Query: 1033 DVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER 1065
+++P + PC +Q +L+ P +R
Sbjct: 213 LKDPVRWPSTIS---PCFKNFLQGLLTKDPRQR 242
Score = 34.3 bits (77), Expect = 0.68
Identities = 18/67 (26%), Positives = 34/67 (50%), Gaps = 1/67 (1%)
Query: 593 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRI-RLPNRELAREKVMREVKALAKLEHPGI 651
+ ++ +G G FG V++ + K A+K I +L E + RE++ + L HP I
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNI 63
Query: 652 VRYFNAW 658
V +++
Sbjct: 64 VHMLDSF 70
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 73.2 bits (178), Expect = 1e-12
Identities = 69/267 (25%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 884 LYIQMQLCRKENLKDWMNGR-------C---------TIEERERSVCLHIFLQIAEAVEF 927
LY+ ++ K NL++++ R C + ++ C + Q+A +E+
Sbjct: 466 LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAY---QVARGMEY 522
Query: 928 LHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQ-DEEEQTVLTPMPAYARHTGQVG 986
L SK +HRDL N+ T D+V+K+ DFGL + D ++T +P
Sbjct: 523 LASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV--------- 573
Query: 987 TKLYMSPEQIHGNSYSHKVDIFSLGLILFELL------YPFSTQMERVRTLTDVRNLKFP 1040
+M+PE + Y+H+ D++S G++L+E+ YP E + L + + P
Sbjct: 574 --KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 631
Query: 1041 PLFTQKYPCEYVMVQDMLSPSPMERPEAINIIE----------NAVFEDLDFPGKTVLRQ 1090
T + Y+M++D P +RP ++E N + DL P L Q
Sbjct: 632 SNCTNEL---YMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMP----LDQ 684
Query: 1091 RSRSL---SSSGTKHSRQSNNSHSPLP 1114
S S SS S SH PLP
Sbjct: 685 YSPSFPDTRSSTCSSGEDSVFSHEPLP 711
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,493,482
Number of Sequences: 37866
Number of extensions: 2142431
Number of successful extensions: 10554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 8093
Number of HSP's gapped (non-prelim): 1823
length of query: 1116
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1003
effective length of database: 13,968,660
effective search space: 14010565980
effective search space used: 14010565980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.