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Search of human proteins with 134152708
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
(273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 511 e-145
gi|148746195 trichohyalin [Homo sapiens] 103 2e-22
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 100 1e-21
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 100 1e-21
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 99 3e-21
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 99 3e-21
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 95 6e-20
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 93 2e-19
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 93 3e-19
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 93 3e-19
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 93 3e-19
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 93 3e-19
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 90 2e-18
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 89 3e-18
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 89 4e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 87 2e-17
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 87 2e-17
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 87 2e-17
gi|62244004 modulator of estrogen induced transcription isoform ... 86 3e-17
gi|63176611 modulator of estrogen induced transcription isoform ... 86 3e-17
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 86 3e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 86 3e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 85 8e-17
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 85 8e-17
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 85 8e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 84 1e-16
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 84 1e-16
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 84 1e-16
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 84 1e-16
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 84 1e-16
>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
Length = 273
Score = 511 bits (1317), Expect = e-145
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS
Sbjct: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE
Sbjct: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
Query: 121 IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR 180
IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR
Sbjct: 121 IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR 180
Query: 181 QAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL 240
QAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL
Sbjct: 181 QAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL 240
Query: 241 EQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD 273
EQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
Sbjct: 241 EQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD 273
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 103 bits (256), Expect = 2e-22
Identities = 85/284 (29%), Positives = 139/284 (48%), Gaps = 25/284 (8%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSR---ESKRNRRRESRSRSR 59
R + + + K+R + R R K++ ++ + + E RRR+ R +
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 60 STNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQK---REEEEKKAEFERQRKI 116
+ + E R R + R K+ L ++++ REE EK+ ER+R+
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 117 R-----QQEIEEKLIEEETARRVEELVAK-RVEEELEKRKDEI-----------EREVLR 159
R QQE E+ L EE RR +EL + R EEEL++ ++++ ERE
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 160 RVEEAKRIMEKQLL-EELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAK 218
R EE + E+QLL EE E++R+ EL Q EEE + + E+L R E R+ E + +
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR-QELERQ 1169
Query: 219 LAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSR 262
EE+ EE++ + EE+ K QER+RQ +EE+++ K K R
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Score = 94.0 bits (232), Expect = 1e-19
Identities = 78/280 (27%), Positives = 138/280 (49%), Gaps = 34/280 (12%)
Query: 6 SRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSR----ST 61
SR K + +++ + R D++++R++ ++ ++ R R+ R +
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Query: 62 NTAVSRRERDRERASSPP-------------DRIDIFGRTVSKRSSLDEKQKREEEEKKA 108
+ R+ERDR+ P DR F +E+Q R +E +
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 109 EFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM 168
E ++++R+QE E K ++EE R +EL K EE E+ + E E+E LRR E ++I+
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREE--EQLRQETEQEQLRRQERYRKIL 1750
Query: 169 EKQLL--EELERQRQAELAAQKAREEEE-RAKREELERILEENNRKIAEAQ---AKLAEE 222
E++ L E E+Q + + +K REEE+ R +REE + +E++RK E + + E+
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 223 QL---------RIVEEQRKIHEERMKLEQERQRQQKEEQK 253
QL R EEQ ++ E+ +L QER RQ + E++
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Score = 92.8 bits (229), Expect = 3e-19
Identities = 72/254 (28%), Positives = 132/254 (51%), Gaps = 21/254 (8%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVS 66
R +H + KH ++R R + +ER R K E +E R + +
Sbjct: 427 REQEEERHEQ--KHEQERREQRLKREQEER-RDWLKREEETERHEQERRKQQLKRDQEEE 483
Query: 67 RRER-----DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAE----FERQRKIR 117
RRER + ER R R +R +++ KR+EEE++ + E+Q +
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERR--EQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 118 QQEIEEKLIEEETARRVE-ELVAKRVEEELEKRKDEI-EREVLRRVEEAKRIMEKQLLEE 175
Q+E E+L++ E +R+E E +R++ E E+R+D++ +RE RR + KR E++L +
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Query: 176 LERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHE 235
L+R+ L ++ RE+ R KREE E EE +++ +++ + Q ++ EQ++ E
Sbjct: 602 LKREEVERLEQEERREQ--RLKREEPE---EERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 236 ERMKLEQERQRQQK 249
+R+K E+E +R ++
Sbjct: 657 QRLKREEEEERLEQ 670
Score = 89.4 bits (220), Expect = 3e-18
Identities = 64/261 (24%), Positives = 131/261 (50%), Gaps = 33/261 (12%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R + R + + + ++ + + R ++R+++ + R R E+ +
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKA-------EFERQRKIR 117
+R+++ ER + L+E+++RE++E++ E R+++++
Sbjct: 475 QLKRDQEEERRE--------------RWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 118 QQEIEEKL-----IEEETARRVEELVAKRVEEELEKRKDEIEREV-LRRVEEAKRIMEKQ 171
+QE EE+L E++ R EE + ++ E EKR ++ RE L+R +E +R Q
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR---DQ 577
Query: 172 LLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEE---QLRIVE 228
LL+ E +RQ L ++ E+R KREE+ER+ +E R+ + + EE QL E
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Query: 229 EQRKIHEERMKLEQERQRQQK 249
EQ + +++++ EQ+ +R+Q+
Sbjct: 638 EQEERRQQQLRREQQERREQR 658
Score = 87.8 bits (216), Expect = 9e-18
Identities = 77/267 (28%), Positives = 138/267 (51%), Gaps = 30/267 (11%)
Query: 8 SSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKS---RESKRNRRRESRSRSRSTNT- 63
S + ++ +K +K+ R R +E+ R+R +E +R R++ R T
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 64 ---AVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKRE-----EEEKKAEFERQRK 115
A + ER R+R S+ P ++ +E+Q+RE EEE+K + RQR+
Sbjct: 770 QWQAEEKSERGRQRLSARPP----LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR 825
Query: 116 IRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIME-KQLLE 174
R++E+ + L EEE +R E A++++EE + +++ ER RR +E +R + + LE
Sbjct: 826 EREKEL-QFLEEEEQLQRRER--AQQLQEEEDGLQEDQER---RRSQEQRRDQKWRWQLE 879
Query: 175 ELERQRQAELAAQKAREEEERAKR-------EELERILEENNRKIAEAQAKLAEEQLRIV 227
E ++R+ L A+ A +E+ R ++ EEL+R E R+ + + EEQL+
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 228 EEQRKIHEERMKLEQERQRQQKEEQKI 254
EEQ E + QER+RQ ++++K+
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKL 966
Score = 87.4 bits (215), Expect = 1e-17
Identities = 76/261 (29%), Positives = 131/261 (50%), Gaps = 29/261 (11%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRS---------------RS 60
+S K + R R R RD+E R+R + +E + R E + +S R
Sbjct: 154 QSEKQERLEQRDRQR-RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 61 TNTAVSRRERDRERASSPPDRID-IFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQ 119
RR+ E+ +R D +F K E R+EEEK E E Q RQ+
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ---RQR 269
Query: 120 EIEEKLIEEETARRVE--ELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELE 177
E++E EEE R++E EL +R EEE ++++ E+++ R+ EE +R +++ E+ E
Sbjct: 270 ELQE---EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 178 -RQRQAELAAQKAREEEERAKREELERILEENNRK---IAEAQAKLAEEQLRIVEEQRKI 233
R++Q E Q+ R E+E + ++L R EE R+ E + + E+QLR ++ R+
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 234 HEERMKLEQERQRQQKEEQKI 254
+ R + + R++Q + EQ++
Sbjct: 387 QQLRREQQLRREQQLRREQQL 407
Score = 87.4 bits (215), Expect = 1e-17
Identities = 72/263 (27%), Positives = 130/263 (49%), Gaps = 16/263 (6%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKE----------RVRKRSKSRESKRNRRR 52
R+ R + + ++R R R R R+KE + R+R++ + + + +
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQR-REREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 53 ESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER 112
E + R RS ++ R + R ++ + + E+Q +EEE++ + E
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 113 QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQL 172
+ K R+QE E + EEE ++ EE + + EE EKR+ + ERE R ++ + E+QL
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLR---EEREKRRRQ-ERERQYRKDKKLQQKEEQL 973
Query: 173 LEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRK 232
L E +R+ + +K REEEE + EE E R+ E + + ++ EE++
Sbjct: 974 LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 233 IHEERMKLE-QERQRQQKEEQKI 254
+ EER K QER+RQ +EE+++
Sbjct: 1034 LREEREKRRLQERERQYREEEEL 1056
Score = 85.9 bits (211), Expect = 3e-17
Identities = 70/261 (26%), Positives = 129/261 (49%), Gaps = 31/261 (11%)
Query: 3 RSRSRSSSRSKHTKSSK-HNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRST 61
+ R + + +S K H + + R +E + R K RE K+ +RRE + R
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR---- 236
Query: 62 NTAVSRRERDRERASSPPDRIDIFGRTVSKRSS--LDEKQKREEEEKKAEFERQRKIRQQ 119
V + E ++E TV ++ L E++ + + E + E E+ RK+ +Q
Sbjct: 237 ---VFQEEEEKEWRKR---------ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 120 EIEEKLIEEE----TARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEE 175
E+ + EEE RR ++L K+ EE E++++ E++ R +E +R E+QL E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR--EQQLRRE 342
Query: 176 LERQRQAELAAQKAREEEERAKREELERILEENNR--KIAEAQAKLAEEQLRIVEEQRKI 233
E +R+ +L RE+EE + ++L R EE R ++ Q E+QLR ++ R+
Sbjct: 343 QEERREQQL----RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Query: 234 HEERMKLEQERQRQQKEEQKI 254
+ R + + R++Q + EQ++
Sbjct: 399 QQLRREQQLRREQQLRREQQL 419
Score = 85.1 bits (209), Expect = 6e-17
Identities = 74/270 (27%), Positives = 138/270 (51%), Gaps = 27/270 (10%)
Query: 13 KHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDR 72
K + ++ +++ R + RD+E R+ + + RR + R + R R
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Query: 73 ERASSPPDRIDIFGRTVSKRSSLDEKQKRE------EEEKKAEFERQR---KIRQQEIEE 123
+ +R+ R S++ E+++R EEEK+ E ER+ K Q+E +
Sbjct: 519 LKRQEEEERLQ--QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 124 KLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAE 183
+L++ E RR + L + EE LE+R ++RE + R+E+ +R ++ EE E +R+ +
Sbjct: 577 QLLKREEERRQQRL-KREQEERLEQR---LKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 184 LAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQE 243
L K+ E+EER ++++L R E+ R+ E + K EE+ R+ + ++ HEE E+
Sbjct: 633 LL--KSEEQEER-RQQQLRR--EQQERR--EQRLKREEEEERLEQRLKREHEE----ERR 681
Query: 244 RQRQQKEEQKIILGKGKSR-PKLSFSLKTQ 272
Q +EEQ+ + KSR PK + L+++
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLESE 711
Score = 85.1 bits (209), Expect = 6e-17
Identities = 72/275 (26%), Positives = 130/275 (47%), Gaps = 27/275 (9%)
Query: 5 RSRSSSRS-KHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNT 63
R R S + +H + + R + R R + ++R + E + + + R R
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 64 AVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEE 123
+ R ER+ +R DR R Q+REE+ + + ER RK R++E+
Sbjct: 1319 QLLREEREEKRRRQETDR--------KFREEEQLLQEREEQPLRRQ-ERDRKFREEELRH 1369
Query: 124 -----KLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELER 178
K +EEE R +E K ++EE + R E E++ LR+ + K E+Q L ER
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ-LRQDRDRKFREEEQQLSRQER 1428
Query: 179 QRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM 238
R K REEE++ +R+E ER E +++ + + + E+ ++++E+ EE+
Sbjct: 1429 DR-------KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER----EEQQ 1477
Query: 239 KLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD 273
QER R+ EE++ + + + R L++Q+
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Score = 85.1 bits (209), Expect = 6e-17
Identities = 69/269 (25%), Positives = 129/269 (47%), Gaps = 24/269 (8%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
+ R R R + + +H + + R KE R+ KS+E K+ R E + R
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLE-REEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 63 TAVSRRERDR---ERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQ 119
T RE ++ ER P R + + E++ R +E+ + E ++++R+Q
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQE-------RDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 120 EIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQ 179
E E K ++EE R +E +++ ++ +++ E E+++ R+ + K E+Q + ER+
Sbjct: 1387 ERERKFLKEEQQLRCQER-EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 180 RQAELAAQKAREEEERAKREELERILEENNRKI--AEAQAKLAEE--QLRIVEEQRKIHE 235
R+ Q+ R+E R REE + + E +++ E K EE QLR E RK E
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 236 ERMK--------LEQERQRQQKEEQKIIL 256
+ ++ LE+E+Q +++ Q+ L
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Score = 84.7 bits (208), Expect = 8e-17
Identities = 68/275 (24%), Positives = 143/275 (52%), Gaps = 34/275 (12%)
Query: 26 RSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIF 85
R R ++E++RK + +E +R R+ E + + R RR+++ ER +R +
Sbjct: 267 RQRELQEEEEQLRKLER-QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 86 GRTVSKRSSLDEKQKREEEEKKA--------EFERQRKIRQQEIEEK----LIEEETARR 133
R + +++ +RE+EE++ E R++++R+++ EE+ L E+ RR
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 134 VEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREE- 192
++L R E++L + + + LRR ++ +R + + ++L R+++ E QK +E
Sbjct: 386 EQQL---RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 193 -EERAKREELERI--------LEENNRKIAEAQAKLAEEQ------LRIVEEQRKIHEER 237
E+R KRE+ ER E + ++ + Q K +E+ L++ EE+R+ +ER
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Query: 238 MKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQ 272
EQ+ +R+Q+E ++ L + + +L L+++
Sbjct: 503 R--EQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Score = 84.7 bits (208), Expect = 8e-17
Identities = 67/274 (24%), Positives = 132/274 (48%), Gaps = 25/274 (9%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESK--RNRRRESRSRSRS 60
+ R R R +H + ++ + ++ RD++ ++ RE + + RR+E+ + R
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340
Query: 61 TNTAVSRRERD--RERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEF-------- 110
+ RE R + R + R L+E+Q+ +E++ +F
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400
Query: 111 --ERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM 168
ER++++RQ + K EEE +E K EEE + R+ E ER+ L ++ ++
Sbjct: 1401 CQEREQQLRQDR-DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 169 ------EKQLLEELERQR-QAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
E+QLL+E E Q+ + +K EEE++ +R+E +R E + E + K E
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 222 EQLRIVEEQRK---IHEERMKLEQERQRQQKEEQ 252
E+ ++ +QR+ + EE+ QER +Q+++++
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Score = 84.7 bits (208), Expect = 8e-17
Identities = 65/268 (24%), Positives = 130/268 (48%), Gaps = 17/268 (6%)
Query: 23 KRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRI 82
++ R R ++ ++R++ + ++ + +R R+ R + ++ R +ER +
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 83 DIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRV---EELVA 139
R +R L E+Q+ +E + +F + ++RQ+ +E+L +E R++ E+L
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 140 KRVEEEL------------EKRKDEIEREVLRRVEEAKRIMEKQLL--EELERQRQAELA 185
+R E++L E+ + E E + LR E ++ E++ L E E+Q + +
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 186 AQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQ 245
K R EEE+ + EE E+ L + + A+ + A ++ EEQ EE K QER+
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Query: 246 RQQKEEQKIILGKGKSRPKLSFSLKTQD 273
R+ +EE K + R + +K+Q+
Sbjct: 1878 RKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/246 (28%), Positives = 124/246 (50%), Gaps = 13/246 (5%)
Query: 23 KRSRSRSRSRDKER-VRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDR 81
+ R + R ++ ER RK+ + ++ + RE R + R R+ R+ E ++
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER--ERQYREEEELQQEEEQ 1062
Query: 82 IDIFGRTVSKRSSLDEKQKREEEEKKAEF----ERQRKIRQQEIEEKLIEEETARRVEEL 137
+ R +R L+ + ++EEE ++ E E K R+QE E + EEE ++ EE
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 138 VAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAK 197
+ + EE ++R+ E+ER+ R EE ++ E+ L EE E++R+ EL Q EEE + +
Sbjct: 1123 LLR--EEREKRRRQELERQY-REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 198 REELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER---MKLEQERQRQQKEEQKI 254
E+L R +E R+ E Q + EE R +QR E++ +K + E +++
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 255 ILGKGK 260
+ KG+
Sbjct: 1240 VYCKGR 1245
Score = 84.0 bits (206), Expect = 1e-16
Identities = 63/257 (24%), Positives = 127/257 (49%), Gaps = 15/257 (5%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R + + K++ + R + +E+ K+ + + R RR E R R
Sbjct: 121 RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW 180
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
R + E+ S G + ++ ++RE E + + +++ +++E +
Sbjct: 181 QEREERRAEEEQLQSCK------GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 123 EKLIEEETAR--RVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLL----EEL 176
+++ +EE + R E V ++ EE+L++ + + +RE L+ EE R +E+Q L +E
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE-LQEEEEQLRKLERQELRRERQEE 293
Query: 177 ERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
E+Q+Q Q+ R ++E +RE+ E E+ R+ E Q + E+QLR +E+R+ +
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERR--EQQEERREQQLRREQEERREQQL 351
Query: 237 RMKLEQERQRQQKEEQK 253
R + E+ER+ QQ ++
Sbjct: 352 RREQEEERREQQLRREQ 368
Score = 84.0 bits (206), Expect = 1e-16
Identities = 63/265 (23%), Positives = 132/265 (49%), Gaps = 12/265 (4%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRES--RSRSRS 60
R R R K + + ++ R + R+++ R+ + R + RR + R +
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLD---EKQKREEEEKKAEFERQRKIR 117
RRE++ ER R R R E+Q R E++ + E ++ R+ +
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQ 417
Query: 118 QQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELE 177
Q E++L E+ R E+ + E+ KR+ E R+ L+R EE +R +++ ++L+
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 178 RQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
R ++ E + + EEE +RE+ ER +++ Q + E++L+ EE+ ++ ++R
Sbjct: 478 RDQEEERRERWLKLEEEE-RREQQER----REQQLRREQEERREQRLKRQEEEERL-QQR 531
Query: 238 MKLEQERQRQQKEEQKIILGKGKSR 262
++ EQ+ +R+Q+E ++ +L + + +
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEK 556
Score = 83.6 bits (205), Expect = 2e-16
Identities = 70/263 (26%), Positives = 122/263 (46%), Gaps = 23/263 (8%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVS 66
R R + + + K R + SR +ER RK + + R + RE +
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSR-QERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 67 RRERDRERASSPPDRIDI-FGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKL 125
R + RE +R + R R L+E+Q+ +E+ +F R++++R QE E K
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF-REQELRSQEPERKF 1517
Query: 126 IEEETARRVEELVAKRVEEELEKRKDEIERE-------VLRRVEEAKRIMEKQLLEELER 178
+EEE ++ K ++EE + R+ E ++ R E+ ++ E+Q L ER
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 179 QRQAELAAQKAR---------EEEERAKREE-LERILEENNRKIAEAQAKL---AEEQLR 225
R+ L QK R E+E++ +R+E +++ +E +RK E + L E+QL
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 226 IVEEQRKIHEERMKLEQERQRQQ 248
E RK EE +L ++ + QQ
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQ 1660
Score = 83.2 bits (204), Expect = 2e-16
Identities = 64/264 (24%), Positives = 128/264 (48%), Gaps = 23/264 (8%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R + K + +R R + + ++R+R+ + R + RRE + R
Sbjct: 267 RQRELQEEEEQLRKLERQELRRER-QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQK-----REEEEKKAEFERQRKIR 117
RRE+ ER R R R +E+++ RE+EE++ E ++ R+ +
Sbjct: 326 ---ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE-QQLRREQ 381
Query: 118 QQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELE 177
Q E++L E+ RR ++L R E++L + + + LRR ++ +R E++ E+
Sbjct: 382 QLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 178 RQRQAELAAQKAREE-------EERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQ 230
Q + E ++ +EE EE +R E ER ++ R + + + E L++ EE+
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR---DQEEERRERWLKLEEEE 495
Query: 231 RKIHEERMKLEQERQRQQKEEQKI 254
R+ +ER + + R+++++ EQ++
Sbjct: 496 RREQQERREQQLRREQEERREQRL 519
Score = 81.6 bits (200), Expect = 7e-16
Identities = 60/254 (23%), Positives = 124/254 (48%), Gaps = 10/254 (3%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSR--SRSTN 62
R R + + ++R + R ++ER+++R +S + R + E R + R
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 63 TAVSRRERDRERASSPPDRID-IFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI 121
+ + R++ +R D + R +R ++++ E E++ + E ++ Q+E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 122 EEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVL-RRVEEAKRIMEKQLLEE-LERQ 179
E+ ++ E + EE+ E+R+ ++ RE RR + KR E++ LE+ L+R+
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 180 RQAELAAQKAREEEERAKREELE-RILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM 238
+ E Q+ EEE+ RE ++ RI + + +EA A+ Q ++ RK +R
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR----QSKVYSRPRKQEGQRR 731
Query: 239 KLEQERQRQQKEEQ 252
+ EQE +R+++E +
Sbjct: 732 RQEQEEKRRRRESE 745
Score = 81.3 bits (199), Expect = 9e-16
Identities = 80/278 (28%), Positives = 134/278 (48%), Gaps = 54/278 (19%)
Query: 20 HNKKRSRSRSRSRDKERVRKRSKSRESKRNR--RRESRSRSRSTNTAVSRRERDRE-RAS 76
H ++R R + + R ++R + R R+R R E + R +SR+ERDR+ R
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 77 SPPDRIDIFGRTVSKRSSLDEKQ--KREEEEKKAEFERQRKIRQQEIEEKLIEEETARRV 134
R R +R ++++Q +R+E +++ ER RK R+ +E+L++E +++
Sbjct: 1585 EQKVR-----RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE---DEQLLQEREEQQL 1636
Query: 135 --EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR-QAELAAQKARE 191
+E K +EEE + R+ E E++ LR + K E+QLL+E E Q+ + + +K RE
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQ-LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 192 EEERAKREELERIL---------------------------------EENNRKIAEAQ-- 216
EE++ +R+E ER +E RKI E +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 217 -AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
+ E+QLR E RK EE +L QER+ QQ Q+
Sbjct: 1756 RPEREEQQLRRQERDRKFREEE-QLRQEREEQQLRSQE 1792
Score = 80.9 bits (198), Expect = 1e-15
Identities = 68/262 (25%), Positives = 128/262 (48%), Gaps = 20/262 (7%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVS 66
R + + + ++ R + R+++ R++ RE + R ++ R +
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 67 RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI 126
RRE++ ER ++ R ++ + KREEE ++ E ER+++ +++ EE+
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 127 E-----EETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
E EE RR ++ +R E++L + ++E + L+R EE +R+ ++ E+ R+ Q
Sbjct: 486 ERWLKLEEEERREQQ---ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQ 542
Query: 182 AELAAQKAREEEE----------RAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQR 231
E Q + EEE R KRE+ ER + R+ Q +L EQ +E++
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 232 KIHE-ERMKLEQER-QRQQKEE 251
K E ER++ E+ R QR ++EE
Sbjct: 603 KREEVERLEQEERREQRLKREE 624
Score = 80.5 bits (197), Expect = 1e-15
Identities = 70/258 (27%), Positives = 131/258 (50%), Gaps = 35/258 (13%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRS------RSTNTA 64
R + + + +K R R +ER RK K + R + RE + R R
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
+SR+ERDR+ F + + ++K EEE++ ER RK R+ EE+
Sbjct: 1423 LSRQERDRK-----------FREEEQQVRRQERERKFLEEEQQLRQERHRKFRE---EEQ 1468
Query: 125 LIEEETARRV--EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
L++E +++ +E K +EEE + R+ E +R+ R E + E++ LEE E+Q
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK-FREQELRSQEPERKFLEE-EQQLHR 1526
Query: 183 ELAAQKAREEEERAKREEL-ERILEENNRKIAEAQAKLAEEQLRIVEEQRKI----HEER 237
+ +K +EE++ +R+E ++ ++ +RK E EEQLR E++++ + +
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE------EEQLRQEREEQQLSRQERDRK 1580
Query: 238 MKLEQERQRQQKEEQKII 255
+LE+++ R+Q++E+K +
Sbjct: 1581 FRLEEQKVRRQEQERKFM 1598
Score = 79.7 bits (195), Expect = 2e-15
Identities = 79/289 (27%), Positives = 139/289 (48%), Gaps = 51/289 (17%)
Query: 13 KHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRN--------RRRESRSRSRSTNTA 64
+ + K ++ + R + RD++ + +S+E +R R++ + +
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQ-KREEEEKKAEFERQRKIRQQEIEE 123
+ R+ER ++R DR F R +E+Q R+E ++K E Q K+R+QE E
Sbjct: 1540 LRRQERGQQRRQ---DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ-KVRRQEQER 1595
Query: 124 KLIEEETA------------------RRVEELVAKRVEEELEK----RKDEIEREVLRRV 161
K +E+E R E+L+ +R E++L + RK E LRR
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 162 EEAKRIM---------EKQLLEELERQR-QAELAAQKAREEEERAKREELER--ILEENN 209
E +++ E+QLL+E E Q+ + + +K REEE++ +R+E ER + EE
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 210 RKIAEAQAKL-AEEQLRIVEEQRKIHEE---RMKLEQERQRQQKEEQKI 254
+ E + K EEQLR EQ ++ + R LE+E+ R ++EEQ++
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL 1764
Score = 78.2 bits (191), Expect = 7e-15
Identities = 63/280 (22%), Positives = 137/280 (48%), Gaps = 24/280 (8%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA------ 64
+ + K + +++ R +KE ++ + R+ + + E R R
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
+ R+E RER + + +R +E+++++EE + E + +R+ +++ E++
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR--EQQERREQQEERREQQ 338
Query: 125 LIEEETARRVEELVAKRVEEELEKRKDEIERE--------VLRRVEEAKRIMEKQLLEEL 176
L E+ RR ++L R E+E E+R+ ++ RE LRR ++ +R E+QL E
Sbjct: 339 LRREQEERREQQL---RREQEEERREQQLRREQEEERREQQLRREQQLRR--EQQLRREQ 393
Query: 177 ERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
+ +R+ +L ++ E++ +RE+ R ++ R+ E + + EQ R + ++ EE
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 237 R---MKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD 273
R +K E+E +R ++E +K L + + + LK ++
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Score = 78.2 bits (191), Expect = 7e-15
Identities = 72/280 (25%), Positives = 135/280 (48%), Gaps = 25/280 (8%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R + R + + + ++R + R +++ER R++ RE + R ++ R +
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEER-REQQLRREQQLRREQQLRREQQLRREQ 399
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
RRE+ R + + + L +Q+ E E+K E ER+ + ++E EE+
Sbjct: 400 QLRREQQLRREQQLRRE-----QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454
Query: 125 LI----EEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR 180
EEET R +E R +++L++ ++E RE ++EE +R +++ E+ R+
Sbjct: 455 RDWLKREEETERHEQE----RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 181 QAELAAQKAR---EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
Q E Q+ + EEE +R E+ L + E K EE+ R+ +E+R E+R
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK-REEEKRLEQERR---EQR 566
Query: 238 MKLEQERQRQQ----KEEQKIILGKGKSRPKLSFSLKTQD 273
+K EQE +R Q +EE++ K + +L LK ++
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Score = 76.3 bits (186), Expect = 3e-14
Identities = 70/284 (24%), Positives = 126/284 (44%), Gaps = 35/284 (12%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRS-----------RSRDKERVRKRSKSRESKRNRR 51
+ R R S K + +KR R + + R+++ +R++ + R+ +
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367
Query: 52 RESRSRSRSTNTAVSRRERDRERASSPPDR-IDIFGRTVSKRSSLDEKQKREEEEKKAEF 110
R + R ++RER ++ + R R D K REEE++ +
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF-REEEQQLSRQ 1426
Query: 111 ERQRK-------IRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEE 163
ER RK +R+QE E K +EEE R E R EE+L + ++E +++ R+ +
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE--QQLHRQERD 1484
Query: 164 AKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQ 223
K + E+Q L ER R+ +++E E + EE + ++ RK + + +L ++
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 224 ------------LRIVEEQRKIHEERMKLEQERQRQ-QKEEQKI 254
R E+ R+ EE+ QER R+ + EEQK+
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Score = 75.9 bits (185), Expect = 4e-14
Identities = 60/259 (23%), Positives = 123/259 (47%), Gaps = 19/259 (7%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKR---NRRRESRSRSR 59
R R + KS + ++R + R + + R ++ + E +R +RE R
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681
Query: 60 STNTAVSRRERDRERASS--PPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIR 117
A +E+ RER S P + + +++S + + +++E +++ + E++ K R
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ-EQEEKRR 740
Query: 118 QQEIEEKLIEEETARRVEELVAKRVEEELE---KRKDEIEREVLRRVEEAKRIMEKQLLE 174
++E E + EEE A R ++ +R + + + K E R+ L + E+QL
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 175 ELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIH 234
E +QR+ ++ +E+ R +R E E+ E Q EEQL+ E +++
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRREREK----------ELQFLEEEEQLQRRERAQQLQ 850
Query: 235 EERMKLEQERQRQQKEEQK 253
EE L+++++R++ +EQ+
Sbjct: 851 EEEDGLQEDQERRRSQEQR 869
Score = 75.1 bits (183), Expect = 6e-14
Identities = 62/268 (23%), Positives = 130/268 (48%), Gaps = 17/268 (6%)
Query: 9 SSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRS--KSRESKRNRRRESRSRSRSTNTAVS 66
S R + S++ + R R ++ + R++ E K RRR+ R R +
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 67 RRE-RDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKL 125
+ + RERA + D +R S +++R +++ + + E +RK R+ + K
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRS---QEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 126 IEEETARRVEELVAKRVEE----ELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
+E R+ ++L+ + EE E EKR+ + + R E+ ++ E+ L EE E++R+
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 182 AELAAQKAREEEERAKREEL------ERILEENNRKIAEAQA-KLAEEQLRIVEEQRKIH 234
E Q ++++ + K E+L +R +E +K E + + EEQL E +++
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 235 EERMKLEQERQRQQKEEQKIILGKGKSR 262
+E + +++ Q+EE++++ + + R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKR 1041
Score = 71.6 bits (174), Expect = 7e-13
Identities = 69/277 (24%), Positives = 136/277 (49%), Gaps = 25/277 (9%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKS-RESKRNRRRESRSRSRSTNT 63
R R ++ K + ++ + R+K R+++R + RE + ++ E + T
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 64 AVSRRERDRERASSPPDRID-----IFGRTVSKRSSLDEKQKREEEEKKAEFERQ----- 113
RR ++ ER + + + KR + +++ EEE+ + E Q
Sbjct: 1071 ---RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 114 -RKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQL 172
K R+QE+E + EEE ++ EE + + EE ++R+ E+ER+ R EE ++ E+ L
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLR--EEPEKRRRQELERQ-YREEEELQQEEEQLL 1184
Query: 173 LEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQL---RIVEE 229
EE E++RQ ++ REEEE +++ +R +E+ R + Q + +E V
Sbjct: 1185 REEQEKRRQER--ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 230 QRKIHEERMKLE--QERQRQQKEEQKIILGKGKSRPK 264
+ + +E+ +LE Q R RQ +++ + +LG+ + R +
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Score = 71.2 bits (173), Expect = 9e-13
Identities = 64/236 (27%), Positives = 114/236 (48%), Gaps = 28/236 (11%)
Query: 26 RSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIF 85
+ R + D+ R R + E + +RR + + + A + +++ DR
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR---- 166
Query: 86 GRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARR-VEELVAKRVEE 144
+ + ++ +E EE++AE E+ + + E EE EE+ RR + EL K EE
Sbjct: 167 -QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 145 ELEKRKD-------EIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAK 197
+ ++R++ E E + R+ E R E++L EE E QRQ EL +EEEE+ +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE-EPQRQREL-----QEEEEQLR 279
Query: 198 REELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
+ E + + E + + Q E+QLR RK EER +E+Q +++E+Q+
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLR-----RKQEEER----REQQEERREQQE 326
Score = 70.1 bits (170), Expect = 2e-12
Identities = 66/245 (26%), Positives = 112/245 (45%), Gaps = 25/245 (10%)
Query: 22 KKRSRSRSRS-RDKERVRKRSKS--RESKRNRRRESRSRSRSTNTAVSRRERDRERASSP 78
K+R + R R R++E +++ + RE + RRR+ R V + E R P
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR-EEP 1158
Query: 79 PDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER----QRKIRQQEIEEKLIEEETARRV 134
R +R L E+Q REEEE + E E+ +++ R+QE E + EEE +R
Sbjct: 1159 EKR---------RRQEL-ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 135 EELVAKRVEEELEKRKDEIEREVLRRVEEAK---RIMEKQLLEELE----RQRQAELAAQ 187
+ R E++ K + E E V + K + E + +LE R RQ++ Q
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Query: 188 KAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQ 247
E++ RE+ R ++ +R E + EEQ RK EE+ L +ER+ +
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 248 QKEEQ 252
++ ++
Sbjct: 1329 RRRQE 1333
Score = 68.9 bits (167), Expect = 4e-12
Identities = 64/281 (22%), Positives = 124/281 (44%), Gaps = 40/281 (14%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R + + + K ++R + R + +ER+ +R K E +R + E R +
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
R + ++ +R R ++ +++ KREEEE++ E +R+ ++ E++
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRR-EQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 125 LIEEETARRVEELVAK--RVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
L EEE + E + ++ + + +LE D + +V R + + +Q EE R+R++
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 183 ELAAQKAREEEERAKREELERI---------------------------LEENNRKIAEA 215
EL Q EEERA R++ E L E + A
Sbjct: 745 ELQWQ----EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 216 QAKLAEEQLRIVEEQRKIHEERMKLEQERQRQ----QKEEQ 252
+ + EQ + EE+ K E+R + +ER+++ ++EEQ
Sbjct: 801 EERQQREQRFLPEEEEK--EQRRRQRREREKELQFLEEEEQ 839
Score = 68.9 bits (167), Expect = 4e-12
Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 34/256 (13%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R + + + +++ R + R R + ++ + +E +R R E + R + + R+ER
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER 1745
Query: 71 DR----ERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI 126
R E P R R +E+Q R+E E ++++R QE + K
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE-------EQQLRSQESDRKFR 1798
Query: 127 EEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAA 186
EEE R+ +R E++L + +R+ R EE + +E+Q + L ++R + A
Sbjct: 1799 EEEQLRQ------EREEQQLRPQ----QRDGKYRWEEEQLQLEEQ-EQRLRQERDRQYRA 1847
Query: 187 QKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQR 246
++ +E+++REE E EE ++ E + KL EE +R R + E++R R
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR-----------RQQKEEQRHR 1896
Query: 247 QQKEEQKIILGKGKSR 262
Q E K GKG R
Sbjct: 1897 -QVGEIKSQEGKGHGR 1911
Score = 68.2 bits (165), Expect = 7e-12
Identities = 58/217 (26%), Positives = 113/217 (52%), Gaps = 29/217 (13%)
Query: 53 ESRSRSRSTNTAVS-RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFE 111
E R+R + + RR+ + +R P DR + +R ++Q+RE E + + E
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDR-QLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 112 RQRKIRQQEIEEKLIEEETARRVEELVAKRVE-EELEKRKDEIEREVLRRVEEAKRIMEK 170
+Q ++ Q++ + RR EEL +R E +E E+R+ E E+ + E + ++
Sbjct: 157 KQERLEQRDRQ---------RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE 207
Query: 171 QLLEELERQRQAELAAQKAREEEERAKREELERILEENNRK--------IAEAQAKLAEE 222
E+L R+ EL +K REE+++ +RE +R+ +E K + + + KL EE
Sbjct: 208 ---EQLRRRELLEL-RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 223 ----QLRIVEEQRKIHE-ERMKLEQERQRQQKEEQKI 254
Q + EE+ ++ + ER +L +ERQ +++++Q++
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Score = 67.8 bits (164), Expect = 1e-11
Identities = 67/286 (23%), Positives = 127/286 (44%), Gaps = 51/286 (17%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKR-NRRRESRSRSRSTNT 63
R + R + + + +++ R + ++++ KR + R +R R +E R R
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 64 AVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFE--------RQRK 115
V R E++ R R + + K EE+E++ + + R+++
Sbjct: 606 EVERLEQEERREQR-------LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 116 IRQQEIEEKL-----IEEETARRVEELVAKRVEE--------------ELEKRKDEIERE 156
++++E EE+L E E RR +EL + E+ +LE D + +
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKI---- 212
V R + + +Q EE R+R++EL Q EEERA R++ E EE R
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQ----EEERAHRQQQE---EEQRRDFTWQW 771
Query: 213 -AEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQK----EEQK 253
AE +++ ++L R+ E +++ E+ +QR+Q+ EE+K
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Score = 65.9 bits (159), Expect = 4e-11
Identities = 65/276 (23%), Positives = 129/276 (46%), Gaps = 38/276 (13%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKS--RESKRNRRRESRSRSRSTNTAVSRRERD-- 71
+ + ++R + R++E V++ + RE RRR+ R + + E
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 72 RERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEF------ERQRKIRQQEIEEKL 125
RE + R + KQ+ +E+++++ E++ +R ++ K
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 126 IEEETARRVEE--LVAKRVEEEL-----EKRKDEIEREVLRRVEEAKRIMEKQLLEELER 178
E E R++E+ L ++ +++L E+++ + E+E R + + E++ LE E
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLER-EE 1303
Query: 179 QRQAELAAQKAREE--------EERAKREELERILEENNRKIAEAQ----------AKLA 220
Q++A+ +K++EE EE+ +R+E +R E + + E + K
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 221 EEQLRIVEEQRKIHEERMKL-EQERQRQ-QKEEQKI 254
EE+LR E+ RK EE +L QER+R+ KEEQ++
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Score = 34.7 bits (78), Expect = 0.092
Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 14/123 (11%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVS 66
R + +S + ++K +++E + R + R+ K E
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL-- 1837
Query: 67 RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRK-----IRQQEI 121
R+ERDR+ + ++S +E++ +EEE+K ER+RK IR+Q+
Sbjct: 1838 RQERDRQYRAEEQF-------ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK 1890
Query: 122 EEK 124
EE+
Sbjct: 1891 EEQ 1893
Score = 32.7 bits (73), Expect = 0.35
Identities = 21/83 (25%), Positives = 45/83 (54%), Gaps = 13/83 (15%)
Query: 191 EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
+EE+RA+ + E +L++ ++ E+Q R R++ EE +R+RQ+++
Sbjct: 96 DEEKRARCDGKESLLQDRRQE---------EDQRRFEPRDRQLEEE----PGQRRRQKRQ 142
Query: 251 EQKIILGKGKSRPKLSFSLKTQD 273
EQ+ L +G+ + + L+ +D
Sbjct: 143 EQERELAEGEEQSEKQERLEQRD 165
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 100 bits (250), Expect = 1e-21
Identities = 81/266 (30%), Positives = 140/266 (52%), Gaps = 27/266 (10%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVR-KRSKSRESKRNRRRESR-SRSRSTNTAVSRRERDRE 73
K S K+R R + R +E + +R K E KR R E + R + RER +
Sbjct: 531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQ 590
Query: 74 RASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI---RQQEIEEKLIEEET 130
+I+ K + +DEK ++ +EE+ AE + ++K + +E+E + +EE
Sbjct: 591 MKEEKKKQIE------QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
Query: 131 ARRV----EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAA 186
ARR+ +E +R +E L+K+K+E E+E LR+ EAKR+ E++ E E++R+ +
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEE-EQERLRKAAEAKRLAEQREQERREQERREQERR 703
Query: 187 QKAREEEERAKRE----------ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
++ R E+ER ++E E ER+ E + E +L +EQL+ E++K EE
Sbjct: 704 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 763
Query: 237 RMKLEQERQRQQKEEQKIILGKGKSR 262
+ +L ERQ Q+++E+K G S+
Sbjct: 764 QQRL-AERQLQEEQEKKAKEAAGASK 788
Score = 81.3 bits (199), Expect = 9e-16
Identities = 63/247 (25%), Positives = 123/247 (49%), Gaps = 25/247 (10%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSR------- 57
R + + + + +K+R + + +ER+RK ++RE + E + +
Sbjct: 546 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
Query: 58 -----SRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER 112
++ ++ + ++ A+ + ++ + + L Q+ EEE + E +
Sbjct: 606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 665
Query: 113 QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQL 172
++K +E +E+L + A+R+ E +R +E E+ + E ER R E+ +R E+QL
Sbjct: 666 KKK---EEEQERLRKAAEAKRLAE---QREQERREQERREQERREQERREQERREQERQL 719
Query: 173 LEELERQRQAELAAQKAREEEERA---KREELERILEENNRKIAEAQAKLAEEQLRIVEE 229
E+ R+ Q L A++ +E E+A ++E+L+R LEE +K E Q +LAE QL+ EE
Sbjct: 720 AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK--EEQQRLAERQLQ--EE 775
Query: 230 QRKIHEE 236
Q K +E
Sbjct: 776 QEKKAKE 782
Score = 71.2 bits (173), Expect = 9e-13
Identities = 49/190 (25%), Positives = 99/190 (52%), Gaps = 20/190 (10%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRR--RESRSRSRSTNTAVSRR 68
+++ K + +++++ ++ ++ E V R K E R R ++ R ++
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 668
Query: 69 ERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK---L 125
E ++ER + +KR + +Q+R E+E++ + R+++ R+QE E+ L
Sbjct: 669 EEEQERLRKAAE---------AKRLAEQREQERREQERREQERREQERREQERREQERQL 719
Query: 126 IEEETARRVEELVAKRVEEELEK----RKDEIEREV--LRRVEEAKRIMEKQLLEELERQ 179
E+E R E L A+R +E EK +K++++RE+ ++ EE +R+ E+QL EE E++
Sbjct: 720 AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
Query: 180 RQAELAAQKA 189
+ A KA
Sbjct: 780 AKEAAGASKA 789
Score = 62.0 bits (149), Expect = 5e-10
Identities = 51/185 (27%), Positives = 95/185 (51%), Gaps = 17/185 (9%)
Query: 95 LDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIE 154
+D K E+E++ +RK +++ + +EE+ RR+EE+ KR EE L K E
Sbjct: 528 MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARE 586
Query: 155 REVLRRVEEAKRIMEK--QLLEELERQRQAELAAQKAREEEERAKREELE--RILEENNR 210
R + E+ K+I +K Q+ E+ E+ ++ LA +KA+++ K EE+E R EE R
Sbjct: 587 RVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
Query: 211 KIAEAQAKLAEEQLRIVEEQRKIHEERM--KLEQERQRQQKEEQKIILGKGKSRPKLSFS 268
++ Q EE+ + H+E + K E+E++R +K + L + + + +
Sbjct: 647 RLRWLQQ----------EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQE 696
Query: 269 LKTQD 273
+ Q+
Sbjct: 697 RREQE 701
Score = 46.2 bits (108), Expect = 3e-05
Identities = 49/179 (27%), Positives = 87/179 (48%), Gaps = 17/179 (9%)
Query: 93 SSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEE-----ETARRVEELVAKRVEEELE 147
S LDE+Q E+EE + R + K++ T +R + L+
Sbjct: 458 SELDEEQHLEDEELQPP--RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTP-TSAPRS 514
Query: 148 KRKDEIEREVLRRVEEAKRIMEK--QLLEELERQRQAELAAQKAREEEERAKREELERIL 205
K I+R R++ +EK Q LE L R+ +AE ++ EE++R + EE++
Sbjct: 515 VMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR 574
Query: 206 EENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
EE RK+ +A+ + EQ++ EE++K E++ E+ + KEE+ L + K++ K
Sbjct: 575 EERLRKVLQARER--VEQMK--EEKKKQIEQKFAQIDEKTEKAKEER---LAEEKAKKK 626
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 100 bits (249), Expect = 1e-21
Identities = 80/271 (29%), Positives = 141/271 (52%), Gaps = 27/271 (9%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVR-KRSKSRESKRNRRRESR-SRSRSTNTAVSRR 68
R+ + K+R R + R +E + +R K E KR R E + R + R
Sbjct: 522 RNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 581
Query: 69 ERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI---RQQEIEEKL 125
ER + +I+ K + +DEK ++ +EE+ AE + ++K + +E+E +
Sbjct: 582 ERVEQMKEEKKKQIE------QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 635
Query: 126 IEEETARRV----EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
+EE ARR+ +E +R +E L+K+K+E E+E LR+ EAKR+ E++ E E++R+
Sbjct: 636 KQEEEARRLRWLQQEEEERRHQELLQKKKEE-EQERLRKAAEAKRLAEQREQERREQERR 694
Query: 182 AELAAQKAREEEERAKRE----------ELERILEENNRKIAEAQAKLAEEQLRIVEEQR 231
+ ++ R E+ER ++E E ER+ E + E +L +EQL+ E++
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEK 754
Query: 232 KIHEERMKLEQERQRQQKEEQKIILGKGKSR 262
K EE+ +L ERQ Q+++E+K G S+
Sbjct: 755 KKKEEQQRL-AERQLQEEQEKKAKEAAGASK 784
Score = 81.3 bits (199), Expect = 9e-16
Identities = 63/247 (25%), Positives = 123/247 (49%), Gaps = 25/247 (10%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSR------- 57
R + + + + +K+R + + +ER+RK ++RE + E + +
Sbjct: 542 RRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 601
Query: 58 -----SRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER 112
++ ++ + ++ A+ + ++ + + L Q+ EEE + E +
Sbjct: 602 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
Query: 113 QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQL 172
++K +E +E+L + A+R+ E +R +E E+ + E ER R E+ +R E+QL
Sbjct: 662 KKK---EEEQERLRKAAEAKRLAE---QREQERREQERREQERREQERREQERREQERQL 715
Query: 173 LEELERQRQAELAAQKAREEEERA---KREELERILEENNRKIAEAQAKLAEEQLRIVEE 229
E+ R+ Q L A++ +E E+A ++E+L+R LEE +K E Q +LAE QL+ EE
Sbjct: 716 AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK--EEQQRLAERQLQ--EE 771
Query: 230 QRKIHEE 236
Q K +E
Sbjct: 772 QEKKAKE 778
Score = 71.2 bits (173), Expect = 9e-13
Identities = 49/190 (25%), Positives = 99/190 (52%), Gaps = 20/190 (10%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRR--RESRSRSRSTNTAVSRR 68
+++ K + +++++ ++ ++ E V R K E R R ++ R ++
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
Query: 69 ERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK---L 125
E ++ER + +KR + +Q+R E+E++ + R+++ R+QE E+ L
Sbjct: 665 EEEQERLRKAAE---------AKRLAEQREQERREQERREQERREQERREQERREQERQL 715
Query: 126 IEEETARRVEELVAKRVEEELEK----RKDEIEREV--LRRVEEAKRIMEKQLLEELERQ 179
E+E R E L A+R +E EK +K++++RE+ ++ EE +R+ E+QL EE E++
Sbjct: 716 AEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 775
Query: 180 RQAELAAQKA 189
+ A KA
Sbjct: 776 AKEAAGASKA 785
Score = 62.0 bits (149), Expect = 5e-10
Identities = 53/189 (28%), Positives = 98/189 (51%), Gaps = 18/189 (9%)
Query: 91 KRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRK 150
KR++ +E+E ++ E R RK +++ + +EE+ RR+EE+ KR EE L K
Sbjct: 521 KRNTPLRMDPKEKERQRLENLR-RKEEAEQLRRQKVEEDKRRRLEEVKLKR-EERLRKVL 578
Query: 151 DEIEREVLRRVEEAKRIMEK--QLLEELERQRQAELAAQKAREEEERAKREELE--RILE 206
ER + E+ K+I +K Q+ E+ E+ ++ LA +KA+++ K EE+E R E
Sbjct: 579 QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE 638
Query: 207 ENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM--KLEQERQRQQKEEQKIILGKGKSRPK 264
E R++ Q EE+ + H+E + K E+E++R +K + L + + + +
Sbjct: 639 EEARRLRWLQQ----------EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 688
Query: 265 LSFSLKTQD 273
+ Q+
Sbjct: 689 REQERREQE 697
Score = 61.6 bits (148), Expect = 7e-10
Identities = 59/266 (22%), Positives = 121/266 (45%), Gaps = 21/266 (7%)
Query: 6 SRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAV 65
+ S+ K SS + +++ + R+ +S KR+ ++ +
Sbjct: 409 ANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLED 468
Query: 66 SRRERDRERASSPP-------DRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQ 118
+ R + S P + F TV + L K+ +R +R
Sbjct: 469 EELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRM 528
Query: 119 QEIEEKLIEEETARRVEE---LVAKRVEEELEKRKDEIEREVLRRVEEAKRIME-KQLLE 174
E++ E RR EE L ++VEE+ +R +E++ L+R E +++++ ++ +E
Sbjct: 529 DPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVK---LKREERLRKVLQARERVE 585
Query: 175 ELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIH 234
+++ +++ ++ + A+ +E+ K +E ER+ EE +K +A AK EE VE +RK
Sbjct: 586 QMKEEKKKQIEQKFAQIDEKTEKAKE-ERLAEEKAKK--KAAAKKMEE----VEARRKQE 638
Query: 235 EERMKLEQERQRQQKEEQKIILGKGK 260
EE +L +Q +++ + +L K K
Sbjct: 639 EEARRLRWLQQEEEERRHQELLQKKK 664
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 99.4 bits (246), Expect = 3e-21
Identities = 73/251 (29%), Positives = 119/251 (47%), Gaps = 19/251 (7%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R R R + +SS NK RSRSR +SRD+ER R+R + RE +R R RE
Sbjct: 361 RDRERDRDRDRE-RSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERER 419
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
RE+D++R D D + R +R +++ +E K E ++K R+ E E
Sbjct: 420 EREREREKDKKR-DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE 478
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
+ EE RR AKR++E LE D+ + + L++ R R+
Sbjct: 479 AE--REEERRREMAKEAKRLKEFLEDYDDD---------RDDPKYYRGSALQKRLRDREK 527
Query: 183 ELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQ 242
E+ E +ER ++ E E + E R +AE E R+ +E + + ++K E
Sbjct: 528 EM------EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEP 581
Query: 243 ERQRQQKEEQK 253
E + +++E+Q+
Sbjct: 582 ESEEEEEEKQE 592
Score = 84.0 bits (206), Expect = 1e-16
Identities = 87/306 (28%), Positives = 142/306 (46%), Gaps = 63/306 (20%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRE-SRSRSRST 61
+ R + + + ++ R R R R++ER R++ K RE +R R R+ R++ R
Sbjct: 300 KERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDR 359
Query: 62 NTAVSR-RERDRERASSPPDRIDIFGRTVSKRSSLDEKQKRE-EEEKKAEFERQRK---- 115
+ R R+RDRER+S DR R+ S+ S D +++RE E E++ E ER+R+
Sbjct: 360 DRDRERDRDRDRERSS---DRNK--DRSRSREKSRDRERERERERERERERERERERERE 414
Query: 116 --------------------------IRQQEIEEKLIEEETARRVEELVAKRVEEELEKR 149
++++E KL E+E A + E L + E + R
Sbjct: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQ-ERLKNWEIRERKKTR 473
Query: 150 --KDEIEREVLRRVE---EAKRIMEKQLLEELERQR-----------QAELA-AQKAREE 192
+ E ERE RR E EAKR+ K+ LE+ + R Q L +K E
Sbjct: 474 EYEKEAEREEERRREMAKEAKRL--KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEA 531
Query: 193 EERAKREELERILEENNRKIAEAQAKLAEEQLRIVEE-----QRKIHEERMKLEQERQRQ 247
+ER ++ E E + E R +AE E R+ +E Q +I +E E+E ++Q
Sbjct: 532 DERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQ 591
Query: 248 QKEEQK 253
+KEE++
Sbjct: 592 EKEEKR 597
Score = 78.6 bits (192), Expect = 6e-15
Identities = 68/253 (26%), Positives = 112/253 (44%), Gaps = 39/253 (15%)
Query: 4 SRSRSSSRSKHTK--SSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRST 61
SR S R H K K K++ R +ER R+R + RE + R R R R
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK 337
Query: 62 NTAVSR-RERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
R RERDR+R RT + D ++ R+ + +++ + + R +E
Sbjct: 338 EKERERERERDRDR-----------DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386
Query: 121 IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR 180
R E +R+ E ERE R E +R E++ E ER+R
Sbjct: 387 ------------------KSRDRERERERERERERE---RERERERERERERERERERER 425
Query: 181 QAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL 240
+ + + +EE+ +R +LER L E K A Q +L ++R ++ R+ +E+ +
Sbjct: 426 EKDKKRDREEDEEDAYERRKLERKLRE---KEAAYQERLKNWEIRERKKTRE-YEKEAER 481
Query: 241 EQERQRQQKEEQK 253
E+ER+R+ +E K
Sbjct: 482 EEERRREMAKEAK 494
Score = 61.6 bits (148), Expect = 7e-10
Identities = 50/192 (26%), Positives = 95/192 (49%), Gaps = 22/192 (11%)
Query: 80 DRIDIFGRTVSK-----RSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRV 134
D+ D+ R +SK + +EK K+E+E ++ E ER+ + R++E E + E E R
Sbjct: 272 DKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERER 331
Query: 135 EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL------AAQK 188
E K E E E+ +D +R+ R +E R +++ + +R+R ++ + +K
Sbjct: 332 EREREKEKERERERERDR-DRD---RTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
Query: 189 AREEE-------ERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLE 241
+R+ E ER + E ER E + E + + +++ R EE + ER KLE
Sbjct: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447
Query: 242 QERQRQQKEEQK 253
++ + ++ Q+
Sbjct: 448 RKLREKEAAYQE 459
Score = 48.9 bits (115), Expect = 5e-06
Identities = 49/225 (21%), Positives = 99/225 (44%), Gaps = 12/225 (5%)
Query: 40 RSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQ 99
++K + S N R E+ + + RD+ + I + ++ S +
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSH 232
Query: 100 KREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLR 159
R+++++K E +R I LI +E +E +EE+ ++D I RE+ +
Sbjct: 233 PRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIE------MEED---KRDLISREISK 283
Query: 160 RVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKL 219
+ K++ E++ +E ERQ + ++ RE E +R E ER E + E + +
Sbjct: 284 FRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERER 343
Query: 220 AEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
E+ R + ++ +R ++ER R + E+ K +SR +
Sbjct: 344 ERERDRDRDRTKERDRDR---DRERDRDRDRERSSDRNKDRSRSR 385
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 99.4 bits (246), Expect = 3e-21
Identities = 72/261 (27%), Positives = 131/261 (50%), Gaps = 26/261 (9%)
Query: 3 RSRSRSSSRSKHTKSSKHNKK---RSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSR 59
+ R R + R + ++ ++ +K R ++R R++ER R++ E + + R R R R
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERER 216
Query: 60 STNTAVSR-----RERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQR 114
T T R RERDR+R +T +R E+++ E E + + ER+R
Sbjct: 217 ETETETERKRQTDRERDRQR------------KTEREREKQAERERASERETERDKERER 264
Query: 115 KIRQQEIEEKLIEEETARRVEELVAKRVEEELE-KRKDEIEREVLRRVEEAKRIMEKQLL 173
+ R ++ + ++E R+ + +R E + E +RK E +RE R E R E++
Sbjct: 265 E-RDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRE-RERERERNRKRERERE 322
Query: 174 EELERQRQAELAAQKAREEEERAKRE-ELERILEENNRKIAEAQAKLAEEQLRIVEEQRK 232
E ER+RQ E + +E E + KR+ E++R E N + E + + E+ R E R+
Sbjct: 323 RERERERQRETERDREKERERKRKRQTEMDR--ERNRQTGREGRRQAERERERERERDRQ 380
Query: 233 IHEERMKLEQERQRQQKEEQK 253
ER + E++R R +++E++
Sbjct: 381 SAREREERERDRDRDRQKERE 401
Score = 94.4 bits (233), Expect = 1e-19
Identities = 78/276 (28%), Positives = 127/276 (46%), Gaps = 32/276 (11%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKE--------------RVRKRSKSRESKRNR 50
R R R K K+ + +R R R R R+ E R RK + RE + R
Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER 248
Query: 51 RRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLD-EKQKREEEEKKAE 109
R S + R+RDR+R +R R +R+ D E +++ E +++ E
Sbjct: 249 ERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERE 308
Query: 110 FERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV-EEAKRIM 168
ER+R R++E E + E +R E ++ E KR+ E++RE R+ E +R
Sbjct: 309 RERERN-RKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQA 367
Query: 169 EKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVE 228
E+ ER+R+ E Q ARE EER ER + + +K E Q + + R E
Sbjct: 368 ER------ERERERERDRQSAREREER------ERDRDRDRQKERERQTEKDRDGQRETE 415
Query: 229 EQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
+QR+ ++R E ER R++ E++ G+ + R +
Sbjct: 416 KQREREKDR---ESERGRERGREREKQKGRERDRER 448
Score = 94.0 bits (232), Expect = 1e-19
Identities = 70/262 (26%), Positives = 126/262 (48%), Gaps = 14/262 (5%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R+R R + + + ++ R R R R+K+R RKR + RE +R+R +E R R T+
Sbjct: 54 RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE---RERQTD 110
Query: 63 TAVSR-------RERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRK 115
R R+++RER + +T +R ++ +E E++ + ERQR+
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170
Query: 116 IRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLR-RVEEAKRIMEKQLLE 174
+ +E+ E+ R E + E + E R E RE R R E + ++Q
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230
Query: 175 ELERQRQAELAAQKAREEEERAKRE---ELERILEENNRKIAEAQAKLAEEQLRIVEEQR 231
E +RQR+ E +K E E ++RE + ER E + + + + K E Q ++R
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRR 290
Query: 232 KIHEERMKLEQERQRQQKEEQK 253
+ + ++ERQR+++ E++
Sbjct: 291 TERDRETERKRERQRERERERE 312
Score = 86.7 bits (213), Expect = 2e-17
Identities = 72/275 (26%), Positives = 125/275 (45%), Gaps = 25/275 (9%)
Query: 3 RSRSRSSSRSKHTKSSKHNKK---RSRSRSRSRDKERVRKRSKSRESKRNRRRE------ 53
R R R R++ + + ++ R R R +ER R+R +E +R RE
Sbjct: 113 RDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTE 172
Query: 54 ---SRSRSRSTNTAVSR-RERDRERASSPPDRIDIFGRTVSKRSSLD---EKQKREEEEK 106
+ R R N R RER RE+ + DR GR + + E++++ + E+
Sbjct: 173 RNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRER 232
Query: 107 KAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLR------- 159
+ + +R+ +Q E+ E ET R E + + + ++R+ E ER+ R
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 160 RVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKL 219
R E +R E+Q E ER+R + ++ R E ER ++ E ER E+ + + Q ++
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERER-ERERERQRETERDREKERERKRKRQTEM 351
Query: 220 AEEQLRIV-EEQRKIHEERMKLEQERQRQQKEEQK 253
E+ R E R+ E + E+ER RQ E++
Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSARERE 386
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/271 (25%), Positives = 121/271 (44%), Gaps = 28/271 (10%)
Query: 4 SRSRSSSRSKHTK---SSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
SR R S+ + H R R+R KER R+R K + + R+ R R +
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER-------- 112
+ R+RDR R + +T +R EK++ ++E++ E ER
Sbjct: 87 RH-----RKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 113 ----QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM 168
QR+ +Q EK E +T R + + ++E E+ K+ ER R E +
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT 201
Query: 169 EKQLLE---ELERQRQAELAAQKARE---EEERAKREELERILEENNRKIAEAQAKLAEE 222
E + E E ER+R+ E ++ R+ E +R ++ E ER + + +E + + +E
Sbjct: 202 EDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKE 261
Query: 223 QLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
+ R E R +R + E+ERQ +K +++
Sbjct: 262 RER--ERDRDRDRDRRQKERERQTDRKRQRR 290
Score = 74.7 bits (182), Expect = 8e-14
Identities = 61/237 (25%), Positives = 103/237 (43%), Gaps = 40/237 (16%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R R R + K + R R R RD+E RKR + RE +R R R+R
Sbjct: 264 RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERE-----RERNR--- 315
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
+RER+RER E++++ E E+ E ER+RK ++Q
Sbjct: 316 ----KRERERERER--------------------ERERQRETERDREKERERKRKRQTEM 351
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
++ +T R +R E +R+ E +R+ R EE +R ++ +E ERQ +
Sbjct: 352 DRERNRQTGRE-----GRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406
Query: 183 ELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMK 239
+ Q+ E E+ + E +R E + E + + E+ R + R+ +R +
Sbjct: 407 DRDGQR---ETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKR 460
Score = 44.3 bits (103), Expect = 1e-04
Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 4/113 (3%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRS-RSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRST 61
R R R R + T+ + ++ + + R R +D+E R R + RE ++ + RE R R R T
Sbjct: 392 RDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE-RDRERQT 450
Query: 62 NTAVSRRERDRERASSPPDRIDIFGRTVS--KRSSLDEKQKREEEEKKAEFER 112
+ R+ + +PP R G S R + + K E+ KA R
Sbjct: 451 DRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTR 503
Score = 34.7 bits (78), Expect = 0.092
Identities = 21/87 (24%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 2 GRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRES------- 54
G+ + + + S+ ++R R R + + +ER R+R R++ R R+R +
Sbjct: 410 GQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPP 469
Query: 55 -RSRSRSTNTAVSRRERDRERASSPPD 80
+RS + +R R SSP D
Sbjct: 470 RTARSGVVQSDPNRPTRGIRWKSSPED 496
Score = 31.6 bits (70), Expect = 0.78
Identities = 20/88 (22%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 175 ELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIH 234
E RQ++ E +K + E E ++ E R + + ++ + + E+ R + R+
Sbjct: 55 ERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERD 114
Query: 235 EERMKLEQERQRQQKEEQKIILGKGKSR 262
+R K E+ RQ++++ E + +G+ R
Sbjct: 115 RQREK-ERNRQKERERETEREGERGRDR 141
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 95.1 bits (235), Expect = 6e-20
Identities = 65/255 (25%), Positives = 136/255 (53%), Gaps = 15/255 (5%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R R + K + KK R + ++E++R+ K +E + R+E + R +
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR 479
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
+ ++E+ +++ R K +EK RE+EEK + ++ KIR+QE EK
Sbjct: 480 QKEKMHEQEKIRKQEEKV---WRQEEKMHDQEEKI-REQEEKM--WRQEEKIREQE--EK 531
Query: 125 LIEEETARRVEELVAKRVEEELEKRKDEI-EREVLRRVEEAKRIMEKQLLEELERQRQAE 183
+ E+E R +E + + EE++ ++++++ E+E +RR EE R E+++ E+ E+ R+ E
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQE 591
Query: 184 LAA----QKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMK 239
+K RE+EE +E E + E K+ E + K+ E++ ++ ++ K+ E+ ++
Sbjct: 592 EKIWEQEEKIREQEEM--MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 649
Query: 240 LEQERQRQQKEEQKI 254
L Q+ ++ Q+ ++ +
Sbjct: 650 LRQQEEKMQEHQEHL 664
Score = 84.7 bits (208), Expect = 8e-17
Identities = 66/257 (25%), Positives = 132/257 (51%), Gaps = 26/257 (10%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R + K + K R + + + ++ + R+ K RE + R + + R + +E+
Sbjct: 393 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK-IHEQEK 451
Query: 71 DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEE---KKAEFERQRKIRQQEI-----E 122
RE R + E++ RE+EE +K + Q KIR+QE E
Sbjct: 452 IREEEK----------RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQE 501
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQR 180
EK+ ++E R +E R EE++ +++++I + E +R EE + E+++ E+ E+ +
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 181 QAE---LAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
+ E +K RE+EE+ RE+ E+I E KI E + K+ E++ + E++ K+ E+
Sbjct: 562 EQEKMRRQEEKIREQEEKI-REQKEKI-REQEEKIWEQEEKIREQEEMMQEQEEKMWEQE 619
Query: 238 MKLEQERQRQQKEEQKI 254
K+ ++ ++ Q++E+K+
Sbjct: 620 EKMCEQEEKMQEQEEKM 636
Score = 80.5 bits (197), Expect = 1e-15
Identities = 64/246 (26%), Positives = 129/246 (52%), Gaps = 36/246 (14%)
Query: 30 RSRDKERVRKRSKSR-ESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRT 88
+ ++E++R++ + R E ++ R +E R + + R++E ++ +
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK-----KM 439
Query: 89 VSKRSSLDEKQKREEEEKKAEFE----RQRKIRQQEI----EEKLIEEETARRVEELVAK 140
+ + E++K EEEK+ E E ++ KIR+QE +EK+ E+E R+ EE
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE---- 495
Query: 141 RVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREE 200
+V + EK D+ E+ +R EE E+++ E+ E+ R+ E +K RE+EE + +E
Sbjct: 496 KVWRQEEKMHDQEEK--IREQEEKMWRQEEKIREQEEKIREQE---EKIREQEEMMQEQE 550
Query: 201 LERILEENNR------------KIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQ 248
E++ E+ + KI E + K+ E++ +I E++ KI E+ K+ ++ + Q
Sbjct: 551 -EKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQ 609
Query: 249 KEEQKI 254
++E+K+
Sbjct: 610 EQEEKM 615
Score = 79.0 bits (193), Expect = 4e-15
Identities = 64/236 (27%), Positives = 118/236 (50%), Gaps = 17/236 (7%)
Query: 34 KERVRKRS-KSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKR 92
+E++R++ K RE + RR+ + E E+ ++ K
Sbjct: 320 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI 379
Query: 93 SSLDEKQK-----REEEEKKAEFER---QRKIRQQEI-----EEKLIEEETARRVEELVA 139
L+EK RE+EEK+ E E+ Q K ++QE EEK+ E+E R +E
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439
Query: 140 KRVEEELEKRKDEIEREVLRRVEEAKRIMEK-QLLEELERQRQAELAAQKAREEEERAKR 198
R EE++ +++ E E + EE R EK + EE+ RQ++ +K R++EE+ R
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWR 499
Query: 199 EELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
+E + + + KI E + K+ ++ +I E++ KI E+ K+ ++ + Q++E+K+
Sbjct: 500 QEEK--MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM 553
Score = 79.0 bits (193), Expect = 4e-15
Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 33/275 (12%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSR--ESKRNRRR------ESRSRSRSTN 62
R + K + +K R +KE +R + E + RR E + R
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI- 121
+ +E+ RE+ + I R KR + K R+EE+ + E++ KIR+QE
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKI--REQEKRQEQEAKMWRQEEKIR---EQEEKIREQEKK 438
Query: 122 ----EEKLIEEETARRVEELVAKRVEEELEKRKDEI-EREVLRRVEEAKRIMEKQLLEEL 176
EEK+ E+E R E+ ++ +EE+ +++++I E+E + R +E EK +E
Sbjct: 439 MWRQEEKIHEQEKIREEEK---RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495
Query: 177 ERQRQAELA---AQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKI 233
+ RQ E +K RE+EE+ R+E + + E KI E + K+ E++ + E++ K+
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEK--IREQEEKIREQEEKIREQEEMMQEQEEKM 553
Query: 234 HEERMKL-EQERQRQQK-----EEQKIILGKGKSR 262
E+ K+ EQE+ R+Q+ +E+KI K K R
Sbjct: 554 GEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIR 588
Score = 77.4 bits (189), Expect = 1e-14
Identities = 69/258 (26%), Positives = 131/258 (50%), Gaps = 39/258 (15%)
Query: 28 RSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRI----D 83
R+ D+E K +K +E + + ES N +R+ +R + P ++ D
Sbjct: 211 RNTITDEELKEKNAKLQE--KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 84 IFGRTVSKRSSLDEKQKREEE--------EKKAEFERQRKIRQ-----QEIEEKLIEEET 130
G+ + S+ + Q E E +++ + ++ KI++ QE EEK+ E+E
Sbjct: 269 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 328
Query: 131 ARRVEELVAKRVEEELEKRKDEIER--EVLRRVEEAKRIMEKQLLEELERQRQAE---LA 185
R +E +R EE + ++++++ R E++ EE R +E+ + E+ E+ R+ E
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHE 388
Query: 186 AQKAREEEERAKREELERILEENNR------------KIAEAQAKLAEEQLRIVEEQRKI 233
+K RE+EE KR+E E+I E+ R KI E + K+ E++ ++ ++ KI
Sbjct: 389 QEKIREQEE--KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 446
Query: 234 HEERMKLEQERQRQQKEE 251
HE+ K+ +E +RQ++EE
Sbjct: 447 HEQE-KIREEEKRQEQEE 463
Score = 77.0 bits (188), Expect = 2e-14
Identities = 57/228 (25%), Positives = 125/228 (54%), Gaps = 23/228 (10%)
Query: 34 KERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRS 93
+E++ ++ K RE + R+ E + R + +R+ + ++I R ++
Sbjct: 383 EEKMHEQEKIREQEEKRQEEEKIREQE------KRQEQEAKMWRQEEKI----REQEEKI 432
Query: 94 SLDEKQKREEEEKKAEFERQRKI-RQQEIEEKLIEEETARRVEELVAKR----VEEELEK 148
EK+ +EEK E E+ R+ ++QE EE +EE R EE+ ++ +E++ K
Sbjct: 433 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Query: 149 RKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILE 206
+++++ + E + EE R E+++ + E+ R+ E +K RE+EE+ + E E +++
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQE---EKIREQEEKIR--EQEEMMQ 547
Query: 207 ENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E K+ E + K+ +EQ ++ ++ KI E+ K+ +++++ +++E+KI
Sbjct: 548 EQEEKMGEQEEKM-QEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594
Score = 57.0 bits (136), Expect = 2e-08
Identities = 46/187 (24%), Positives = 96/187 (51%), Gaps = 14/187 (7%)
Query: 16 KSSKHNKKRSRSRSRSRDKE-RVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRER 74
K K +K R + D+E ++R++ + + + RE + R + E+ RE+
Sbjct: 489 KIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIRE------QEEKIREQ 542
Query: 75 ASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEF---ERQRKIRQQEIEEKLIEEETA 131
++ + G K ++ +++EE+ ++ E E++ KIR+Q EEK+ E+E
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ--EEKIWEQEEK 600
Query: 132 RRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKA 189
R +E + + EE++ ++++++ + E ++ EE R E+++ E+ R RQ E Q+
Sbjct: 601 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 660
Query: 190 REEEERA 196
+E E A
Sbjct: 661 QEHLEAA 667
Score = 49.7 bits (117), Expect = 3e-06
Identities = 40/155 (25%), Positives = 78/155 (50%), Gaps = 10/155 (6%)
Query: 102 EEEEKKAEFERQRKIRQQEIEEKLIE---EETARRVEELVAKRVEEELEKRKDEIEREVL 158
+EE K+ + Q K++ E E+ I+ +E R++E +++L+ D + +E+
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 159 RRVEEAK-RIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQA 217
+ + ++ E +L L +Q++ ++ Q+ + +E K +E E + E KI E
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ-- 333
Query: 218 KLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQ 252
EE++R EE EE+M+ QE +KEE+
Sbjct: 334 ---EEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEK 364
Score = 46.6 bits (109), Expect = 2e-05
Identities = 33/158 (20%), Positives = 81/158 (51%), Gaps = 6/158 (3%)
Query: 99 QKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIE---R 155
QK++ + E ++R E+ I +E + + ++++ +E K EI+ +
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL-VESEKSEIQLNVK 245
Query: 156 EVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEA 215
E+ R++E AK ++ +Q L+ EL + A+ + + + E R+ ++ K+
Sbjct: 246 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 305
Query: 216 QAKLAEEQLRIVEEQRK-IHEERMKLEQERQRQQKEEQ 252
+ K+ E + +I +EQ + I E+ K+ ++ ++ +++E+
Sbjct: 306 EEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEE 342
Score = 41.6 bits (96), Expect = 8e-04
Identities = 37/182 (20%), Positives = 85/182 (46%), Gaps = 17/182 (9%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + + K R + R +E++R++ + + + RE +
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE 550
Query: 63 TAVSRRE---RDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAE-FERQRKIRQ 118
+ +E +++E+ ++I ++ +QK + E++ + +E++ KIR+
Sbjct: 551 EKMGEQEEKMQEQEKMRRQEEKI-------REQEEKIREQKEKIREQEEKIWEQEEKIRE 603
Query: 119 -----QEIEEKLIEEETARRVEELVAKRVEEELEKRKDEI-EREVLRRVEEAKRIMEKQL 172
QE EEK+ E+E +E + EE++ ++++++ E+EV R +E K ++
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 663
Query: 173 LE 174
LE
Sbjct: 664 LE 665
Score = 40.4 bits (93), Expect = 0.002
Identities = 29/157 (18%), Positives = 73/157 (46%), Gaps = 6/157 (3%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
M R + + + + + + + ++++ + K +E ++ RR+E + R +
Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
++E+ RE+ ++ + R + E++ E+EEK E E + QE
Sbjct: 578 EKIR-EQKEKIREQEEKIWEQEEKI-REQEEMMQEQEEKMWEQEEKMCEQEE----KMQE 631
Query: 121 IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREV 157
EEK+ +E +E+ ++ EE++++ ++ +E +
Sbjct: 632 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 93.2 bits (230), Expect = 2e-19
Identities = 83/282 (29%), Positives = 139/282 (49%), Gaps = 48/282 (17%)
Query: 8 SSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRE-----SRSRSRSTN 62
+ + + SK +KRSR+ R RD++R RK S S++ KR+R R+ SRSRSRS +
Sbjct: 6 ADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRS 65
Query: 63 TAVSR------RERDRERASSPPDR-IDIFGRTVS---KRSSL------DEKQKREEEEK 106
+ R RERD+ER + DR D G KRSSL D K +++ + K
Sbjct: 66 KSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSK 125
Query: 107 KAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKR-----KDEIEREVLRR- 160
K E + E +K + + E L K+ EEE E + K E E E L+R
Sbjct: 126 KDE--------EDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRR 177
Query: 161 ---VEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQA 217
VEE +R++E++ + + Q + +E E R +RE +ER E N + E +
Sbjct: 178 QQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMER--ETNGNEDEEGRQ 235
Query: 218 KLAEEQLRIVEEQRKIHEERMK----LEQERQRQQKEEQKII 255
K+ EE+ ++ +++H + + +++ R+ + ++K +
Sbjct: 236 KIREEK----DKSKELHAIKERYLGGIKKRRRTRHLNDRKFV 273
Score = 31.2 bits (69), Expect = 1.0
Identities = 30/140 (21%), Positives = 58/140 (41%), Gaps = 26/140 (18%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRS------ 58
R R + + + +K + +S++ +++R KR R R R
Sbjct: 218 RERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWD 277
Query: 59 RSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREE--------------E 104
S +T++ +ER ++ + GR L ++QKRE+ E
Sbjct: 278 ASEDTSIDYNPLYKER-----HQVQLLGRGFIAGIDL-KQQKREQSRFYGDLMEKRRTLE 331
Query: 105 EKKAEFERQRKIRQQEIEEK 124
EK+ E R RK+R++E +++
Sbjct: 332 EKEQEEARLRKLRKKEAKQR 351
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 92.8 bits (229), Expect = 3e-19
Identities = 63/250 (25%), Positives = 118/250 (47%), Gaps = 7/250 (2%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + + + +R + R +E RKR + E R ++ E+ R R
Sbjct: 736 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 795
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
A+ R+ + ER + R +R +E++K+EE +K E E + R++E
Sbjct: 796 IALRRQREEEERQQQE----EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 851
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKD-EIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
++ +EE R EE R EEE KRK+ E++R+ + + ++ ++ L ++Q+Q
Sbjct: 852 QRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ--KELMRQRQQQQEALRRLQQQQQQ 909
Query: 182 AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLE 241
+LA K ++ + +AE Q E + ++ EEQR+ E MK
Sbjct: 910 QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 969
Query: 242 QERQRQQKEE 251
Q++Q+QQ+++
Sbjct: 970 QQQQQQQQQK 979
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/174 (36%), Positives = 101/174 (58%), Gaps = 16/174 (9%)
Query: 91 KRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRK 150
+R + + KREEEE+K + E +R+ Q+EI + EEE RR EE +A+R +EE +R+
Sbjct: 734 ERREAEMRAKREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRKQEEALRRQ 791
Query: 151 DEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE-----EEERAK----REEL 201
E E + R+ EE +R +++ L LE +R+ E +K E EEE AK EE
Sbjct: 792 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 851
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKII 255
+R LEEN ++ E A+L E EE+RK E ++ ++E RQ++++Q+ +
Sbjct: 852 QRRLEENRLRMEEEAARLRHE-----EEERKRKELEVQRQKELMRQRQQQQEAL 900
Score = 89.7 bits (221), Expect = 2e-18
Identities = 75/279 (26%), Positives = 142/279 (50%), Gaps = 51/279 (18%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R ++ + ++R R R +E + +R + E KR RE +R RR+R
Sbjct: 736 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR---REEEELARRKQEEALRRQR 792
Query: 71 DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI--RQQEIEEKLIEE 128
++E A +++REEEE++ + E R++ R++E EE+ +E
Sbjct: 793 EQEIAL---------------------RRQREEEERQQQEEALRRLEERRREEEERRKQE 831
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM---EKQLLEELERQRQAELA 185
E R+ EE AK EE E+ + +E LR EEA R+ E++ +ELE QRQ EL
Sbjct: 832 ELLRKQEEEAAKWAREE-EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 890
Query: 186 AQKAREEE--ERAKREELERIL------------EENNRKIAEAQAKLAEEQLRIVEE-- 229
Q+ +++E R ++++ ++ L +++N ++QA L+ +++ +EE
Sbjct: 891 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 950
Query: 230 QRKIHEERMKLEQE-----RQRQQKEEQKIILGKGKSRP 263
+R++ EE+ + ++E +Q+QQ+++QK+ S+P
Sbjct: 951 ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKP 989
Score = 88.6 bits (218), Expect = 5e-18
Identities = 67/172 (38%), Positives = 98/172 (56%), Gaps = 16/172 (9%)
Query: 89 VSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEK 148
+ K + +Q+R E E +A+ E + + RQ+E+ + EE R+ EE +R EEEL +
Sbjct: 723 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ-EEILRRQQEEERKRREEEELAR 781
Query: 149 RKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL---AAQKAREEEERAKREELERIL 205
RK E E LRR E + + +Q EE ERQ+Q E ++ REEEER K+EEL R
Sbjct: 782 RKQE---EALRRQREQEIALRRQ-REEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 837
Query: 206 EENNRKIA----EAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
EE K A EAQ +L E +LR+ EE ++ E E+ER+R++ E Q+
Sbjct: 838 EEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE----EEERKRKELEVQR 885
Score = 62.8 bits (151), Expect = 3e-10
Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 38/153 (24%)
Query: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIERE 156
E+ ++ E+ K A+ E++R R+ E+ K EEE +R EEL +R +EE+ +R+ E ER+
Sbjct: 718 EQLQQLEKAKAAKLEQER--REAEMRAKR-EEEERKRQEEL--RRQQEEILRRQQEEERK 772
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
E A+R E E L RQR+ E+A ++ REEEER ++EE R LEE R+
Sbjct: 773 RREEEELARRKQE----EALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE----- 823
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQK 249
E+ER++Q++
Sbjct: 824 ------------------------EEERRKQEE 832
Score = 54.7 bits (130), Expect = 9e-08
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 23/137 (16%)
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQK 188
E +++E+ A ++E+E + E E R EE KR EEL RQ Q E+ ++
Sbjct: 718 EQLQQLEKAKAAKLEQE----RREAEMRAKREEEERKR------QEELRRQ-QEEILRRQ 766
Query: 189 AREEEERAKREELERILEEN------------NRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
EE +R + EEL R +E R+ E + + EE LR +EE+R+ EE
Sbjct: 767 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 826
Query: 237 RMKLEQERQRQQKEEQK 253
R K E+ ++Q++E K
Sbjct: 827 RRKQEELLRKQEEEAAK 843
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/64 (34%), Positives = 42/64 (65%), Gaps = 5/64 (7%)
Query: 191 EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
++ E+AK +LE+ R+ AE +AK EE+ + EE R+ EE ++ +QE +R+++E
Sbjct: 721 QQLEKAKAAKLEQ-----ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775
Query: 251 EQKI 254
E+++
Sbjct: 776 EEEL 779
Score = 28.5 bits (62), Expect = 6.6
Identities = 46/220 (20%), Positives = 80/220 (36%), Gaps = 43/220 (19%)
Query: 32 RDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSK 91
RD ER R S RRR R + ER R S ID
Sbjct: 227 RDGERWRPHSPGWREHMERRRRFEFDFRDRDD-----ERGYRRVRSGSGSID------DD 275
Query: 92 RSSLDEKQKREEEEKKAEFERQ------RKIRQQEIEEKLIEEETARRVEE--------- 136
R SL E + EE+ F+ +K++++ I E+ +E R V+E
Sbjct: 276 RDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEE--QEMDFRPVDEGEECSDSEG 333
Query: 137 ---LVAKRVEEELEKRKDEIEREVLRRVEEAKRIM------------EKQLLEELERQRQ 181
AK ++ +K ++ +R + EE + + Q + ER+ +
Sbjct: 334 SHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDE 393
Query: 182 AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
+ + EEE R + ++ + +A+ Q L++
Sbjct: 394 PKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQ 433
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 92.8 bits (229), Expect = 3e-19
Identities = 63/250 (25%), Positives = 118/250 (47%), Gaps = 7/250 (2%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + + + +R + R +E RKR + E R ++ E+ R R
Sbjct: 763 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 822
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
A+ R+ + ER + R +R +E++K+EE +K E E + R++E
Sbjct: 823 IALRRQREEEERQQQE----EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 878
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKD-EIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
++ +EE R EE R EEE KRK+ E++R+ + + ++ ++ L ++Q+Q
Sbjct: 879 QRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ--KELMRQRQQQQEALRRLQQQQQQ 936
Query: 182 AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLE 241
+LA K ++ + +AE Q E + ++ EEQR+ E MK
Sbjct: 937 QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 996
Query: 242 QERQRQQKEE 251
Q++Q+QQ+++
Sbjct: 997 QQQQQQQQQK 1006
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/174 (36%), Positives = 101/174 (58%), Gaps = 16/174 (9%)
Query: 91 KRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRK 150
+R + + KREEEE+K + E +R+ Q+EI + EEE RR EE +A+R +EE +R+
Sbjct: 761 ERREAEMRAKREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRKQEEALRRQ 818
Query: 151 DEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE-----EEERAK----REEL 201
E E + R+ EE +R +++ L LE +R+ E +K E EEE AK EE
Sbjct: 819 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 878
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKII 255
+R LEEN ++ E A+L E EE+RK E ++ ++E RQ++++Q+ +
Sbjct: 879 QRRLEENRLRMEEEAARLRHE-----EEERKRKELEVQRQKELMRQRQQQQEAL 927
Score = 89.7 bits (221), Expect = 2e-18
Identities = 75/279 (26%), Positives = 142/279 (50%), Gaps = 51/279 (18%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R ++ + ++R R R +E + +R + E KR RE +R RR+R
Sbjct: 763 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR---REEEELARRKQEEALRRQR 819
Query: 71 DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI--RQQEIEEKLIEE 128
++E A +++REEEE++ + E R++ R++E EE+ +E
Sbjct: 820 EQEIAL---------------------RRQREEEERQQQEEALRRLEERRREEEERRKQE 858
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM---EKQLLEELERQRQAELA 185
E R+ EE AK EE E+ + +E LR EEA R+ E++ +ELE QRQ EL
Sbjct: 859 ELLRKQEEEAAKWAREE-EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 917
Query: 186 AQKAREEE--ERAKREELERIL------------EENNRKIAEAQAKLAEEQLRIVEE-- 229
Q+ +++E R ++++ ++ L +++N ++QA L+ +++ +EE
Sbjct: 918 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 977
Query: 230 QRKIHEERMKLEQE-----RQRQQKEEQKIILGKGKSRP 263
+R++ EE+ + ++E +Q+QQ+++QK+ S+P
Sbjct: 978 ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKP 1016
Score = 88.6 bits (218), Expect = 5e-18
Identities = 67/172 (38%), Positives = 98/172 (56%), Gaps = 16/172 (9%)
Query: 89 VSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEK 148
+ K + +Q+R E E +A+ E + + RQ+E+ + EE R+ EE +R EEEL +
Sbjct: 750 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ-EEILRRQQEEERKRREEEELAR 808
Query: 149 RKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL---AAQKAREEEERAKREELERIL 205
RK E E LRR E + + +Q EE ERQ+Q E ++ REEEER K+EEL R
Sbjct: 809 RKQE---EALRRQREQEIALRRQ-REEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 864
Query: 206 EENNRKIA----EAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
EE K A EAQ +L E +LR+ EE ++ E E+ER+R++ E Q+
Sbjct: 865 EEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE----EEERKRKELEVQR 912
Score = 62.8 bits (151), Expect = 3e-10
Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 38/153 (24%)
Query: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIERE 156
E+ ++ E+ K A+ E++R R+ E+ K EEE +R EEL +R +EE+ +R+ E ER+
Sbjct: 745 EQLQQLEKAKAAKLEQER--REAEMRAKR-EEEERKRQEEL--RRQQEEILRRQQEEERK 799
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
E A+R E E L RQR+ E+A ++ REEEER ++EE R LEE R+
Sbjct: 800 RREEEELARRKQE----EALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE----- 850
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQK 249
E+ER++Q++
Sbjct: 851 ------------------------EEERRKQEE 859
Score = 54.7 bits (130), Expect = 9e-08
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 23/137 (16%)
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQK 188
E +++E+ A ++E+E + E E R EE KR EEL RQ Q E+ ++
Sbjct: 745 EQLQQLEKAKAAKLEQE----RREAEMRAKREEEERKR------QEELRRQ-QEEILRRQ 793
Query: 189 AREEEERAKREELERILEEN------------NRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
EE +R + EEL R +E R+ E + + EE LR +EE+R+ EE
Sbjct: 794 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 853
Query: 237 RMKLEQERQRQQKEEQK 253
R K E+ ++Q++E K
Sbjct: 854 RRKQEELLRKQEEEAAK 870
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/64 (34%), Positives = 42/64 (65%), Gaps = 5/64 (7%)
Query: 191 EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
++ E+AK +LE+ R+ AE +AK EE+ + EE R+ EE ++ +QE +R+++E
Sbjct: 748 QQLEKAKAAKLEQ-----ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802
Query: 251 EQKI 254
E+++
Sbjct: 803 EEEL 806
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 92.8 bits (229), Expect = 3e-19
Identities = 63/250 (25%), Positives = 118/250 (47%), Gaps = 7/250 (2%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + + + +R + R +E RKR + E R ++ E+ R R
Sbjct: 742 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 801
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
A+ R+ + ER + R +R +E++K+EE +K E E + R++E
Sbjct: 802 IALRRQREEEERQQQE----EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKD-EIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
++ +EE R EE R EEE KRK+ E++R+ + + ++ ++ L ++Q+Q
Sbjct: 858 QRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ--KELMRQRQQQQEALRRLQQQQQQ 915
Query: 182 AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLE 241
+LA K ++ + +AE Q E + ++ EEQR+ E MK
Sbjct: 916 QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 975
Query: 242 QERQRQQKEE 251
Q++Q+QQ+++
Sbjct: 976 QQQQQQQQQK 985
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/174 (36%), Positives = 101/174 (58%), Gaps = 16/174 (9%)
Query: 91 KRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRK 150
+R + + KREEEE+K + E +R+ Q+EI + EEE RR EE +A+R +EE +R+
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 151 DEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE-----EEERAK----REEL 201
E E + R+ EE +R +++ L LE +R+ E +K E EEE AK EE
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKII 255
+R LEEN ++ E A+L E EE+RK E ++ ++E RQ++++Q+ +
Sbjct: 858 QRRLEENRLRMEEEAARLRHE-----EEERKRKELEVQRQKELMRQRQQQQEAL 906
Score = 89.7 bits (221), Expect = 2e-18
Identities = 75/279 (26%), Positives = 142/279 (50%), Gaps = 51/279 (18%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R ++ + ++R R R +E + +R + E KR RE +R RR+R
Sbjct: 742 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR---REEEELARRKQEEALRRQR 798
Query: 71 DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI--RQQEIEEKLIEE 128
++E A +++REEEE++ + E R++ R++E EE+ +E
Sbjct: 799 EQEIAL---------------------RRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM---EKQLLEELERQRQAELA 185
E R+ EE AK EE E+ + +E LR EEA R+ E++ +ELE QRQ EL
Sbjct: 838 ELLRKQEEEAAKWAREE-EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 896
Query: 186 AQKAREEE--ERAKREELERIL------------EENNRKIAEAQAKLAEEQLRIVEE-- 229
Q+ +++E R ++++ ++ L +++N ++QA L+ +++ +EE
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 956
Query: 230 QRKIHEERMKLEQE-----RQRQQKEEQKIILGKGKSRP 263
+R++ EE+ + ++E +Q+QQ+++QK+ S+P
Sbjct: 957 ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKP 995
Score = 88.6 bits (218), Expect = 5e-18
Identities = 67/172 (38%), Positives = 98/172 (56%), Gaps = 16/172 (9%)
Query: 89 VSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEK 148
+ K + +Q+R E E +A+ E + + RQ+E+ + EE R+ EE +R EEEL +
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ-EEILRRQQEEERKRREEEELAR 787
Query: 149 RKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL---AAQKAREEEERAKREELERIL 205
RK E E LRR E + + +Q EE ERQ+Q E ++ REEEER K+EEL R
Sbjct: 788 RKQE---EALRRQREQEIALRRQ-REEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 206 EENNRKIA----EAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
EE K A EAQ +L E +LR+ EE ++ E E+ER+R++ E Q+
Sbjct: 844 EEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE----EEERKRKELEVQR 891
Score = 62.8 bits (151), Expect = 3e-10
Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 38/153 (24%)
Query: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIERE 156
E+ ++ E+ K A+ E++R R+ E+ K EEE +R EEL +R +EE+ +R+ E ER+
Sbjct: 724 EQLQQLEKAKAAKLEQER--REAEMRAKR-EEEERKRQEEL--RRQQEEILRRQQEEERK 778
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
E A+R E E L RQR+ E+A ++ REEEER ++EE R LEE R+
Sbjct: 779 RREEEELARRKQE----EALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE----- 829
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQK 249
E+ER++Q++
Sbjct: 830 ------------------------EEERRKQEE 838
Score = 54.7 bits (130), Expect = 9e-08
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 23/137 (16%)
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQK 188
E +++E+ A ++E+E + E E R EE KR EEL RQ Q E+ ++
Sbjct: 724 EQLQQLEKAKAAKLEQE----RREAEMRAKREEEERKR------QEELRRQ-QEEILRRQ 772
Query: 189 AREEEERAKREELERILEEN------------NRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
EE +R + EEL R +E R+ E + + EE LR +EE+R+ EE
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 237 RMKLEQERQRQQKEEQK 253
R K E+ ++Q++E K
Sbjct: 833 RRKQEELLRKQEEEAAK 849
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/64 (34%), Positives = 42/64 (65%), Gaps = 5/64 (7%)
Query: 191 EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
++ E+AK +LE+ R+ AE +AK EE+ + EE R+ EE ++ +QE +R+++E
Sbjct: 727 QQLEKAKAAKLEQ-----ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 251 EQKI 254
E+++
Sbjct: 782 EEEL 785
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 92.8 bits (229), Expect = 3e-19
Identities = 63/250 (25%), Positives = 118/250 (47%), Gaps = 7/250 (2%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + + + +R + R +E RKR + E R ++ E+ R R
Sbjct: 742 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQE 801
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
A+ R+ + ER + R +R +E++K+EE +K E E + R++E
Sbjct: 802 IALRRQREEEERQQQE----EALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKD-EIEREVLRRVEEAKRIMEKQLLEELERQRQ 181
++ +EE R EE R EEE KRK+ E++R+ + + ++ ++ L ++Q+Q
Sbjct: 858 QRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ--KELMRQRQQQQEALRRLQQQQQQ 915
Query: 182 AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLE 241
+LA K ++ + +AE Q E + ++ EEQR+ E MK
Sbjct: 916 QQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKAL 975
Query: 242 QERQRQQKEE 251
Q++Q+QQ+++
Sbjct: 976 QQQQQQQQQK 985
Score = 90.9 bits (224), Expect = 1e-18
Identities = 63/174 (36%), Positives = 101/174 (58%), Gaps = 16/174 (9%)
Query: 91 KRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRK 150
+R + + KREEEE+K + E +R+ Q+EI + EEE RR EE +A+R +EE +R+
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQ--QEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 151 DEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE-----EEERAK----REEL 201
E E + R+ EE +R +++ L LE +R+ E +K E EEE AK EE
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA 857
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKII 255
+R LEEN ++ E A+L E EE+RK E ++ ++E RQ++++Q+ +
Sbjct: 858 QRRLEENRLRMEEEAARLRHE-----EEERKRKELEVQRQKELMRQRQQQQEAL 906
Score = 89.7 bits (221), Expect = 2e-18
Identities = 75/279 (26%), Positives = 142/279 (50%), Gaps = 51/279 (18%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R ++ + ++R R R +E + +R + E KR RE +R RR+R
Sbjct: 742 REAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKR---REEEELARRKQEEALRRQR 798
Query: 71 DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKI--RQQEIEEKLIEE 128
++E A +++REEEE++ + E R++ R++E EE+ +E
Sbjct: 799 EQEIAL---------------------RRQREEEERQQQEEALRRLEERRREEEERRKQE 837
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM---EKQLLEELERQRQAELA 185
E R+ EE AK EE E+ + +E LR EEA R+ E++ +ELE QRQ EL
Sbjct: 838 ELLRKQEEEAAKWAREE-EEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELM 896
Query: 186 AQKAREEE--ERAKREELERIL------------EENNRKIAEAQAKLAEEQLRIVEE-- 229
Q+ +++E R ++++ ++ L +++N ++QA L+ +++ +EE
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEER 956
Query: 230 QRKIHEERMKLEQE-----RQRQQKEEQKIILGKGKSRP 263
+R++ EE+ + ++E +Q+QQ+++QK+ S+P
Sbjct: 957 ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKP 995
Score = 88.6 bits (218), Expect = 5e-18
Identities = 67/172 (38%), Positives = 98/172 (56%), Gaps = 16/172 (9%)
Query: 89 VSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEK 148
+ K + +Q+R E E +A+ E + + RQ+E+ + EE R+ EE +R EEEL +
Sbjct: 729 LEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQ-EEILRRQQEEERKRREEEELAR 787
Query: 149 RKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL---AAQKAREEEERAKREELERIL 205
RK E E LRR E + + +Q EE ERQ+Q E ++ REEEER K+EEL R
Sbjct: 788 RKQE---EALRRQREQEIALRRQ-REEEERQQQEEALRRLEERRREEEERRKQEELLRKQ 843
Query: 206 EENNRKIA----EAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
EE K A EAQ +L E +LR+ EE ++ E E+ER+R++ E Q+
Sbjct: 844 EEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE----EEERKRKELEVQR 891
Score = 62.8 bits (151), Expect = 3e-10
Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 38/153 (24%)
Query: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIERE 156
E+ ++ E+ K A+ E++R R+ E+ K EEE +R EEL +R +EE+ +R+ E ER+
Sbjct: 724 EQLQQLEKAKAAKLEQER--REAEMRAKR-EEEERKRQEEL--RRQQEEILRRQQEEERK 778
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
E A+R E E L RQR+ E+A ++ REEEER ++EE R LEE R+
Sbjct: 779 RREEEELARRKQE----EALRRQREQEIALRRQREEEERQQQEEALRRLEERRRE----- 829
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQK 249
E+ER++Q++
Sbjct: 830 ------------------------EEERRKQEE 838
Score = 54.7 bits (130), Expect = 9e-08
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 23/137 (16%)
Query: 129 ETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQK 188
E +++E+ A ++E+E + E E R EE KR EEL RQ Q E+ ++
Sbjct: 724 EQLQQLEKAKAAKLEQE----RREAEMRAKREEEERKR------QEELRRQ-QEEILRRQ 772
Query: 189 AREEEERAKREELERILEEN------------NRKIAEAQAKLAEEQLRIVEEQRKIHEE 236
EE +R + EEL R +E R+ E + + EE LR +EE+R+ EE
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 237 RMKLEQERQRQQKEEQK 253
R K E+ ++Q++E K
Sbjct: 833 RRKQEELLRKQEEEAAK 849
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/64 (34%), Positives = 42/64 (65%), Gaps = 5/64 (7%)
Query: 191 EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
++ E+AK +LE+ R+ AE +AK EE+ + EE R+ EE ++ +QE +R+++E
Sbjct: 727 QQLEKAKAAKLEQ-----ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 251 EQKI 254
E+++
Sbjct: 782 EEEL 785
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 89.7 bits (221), Expect = 2e-18
Identities = 77/246 (31%), Positives = 122/246 (49%), Gaps = 21/246 (8%)
Query: 2 GRSRSRSSSRSKHTKSSKH-NKKRSRSRSRSRDKERVR----KRSKSRESKRNRRRESRS 56
GRS SRS SRS K SK + +RSRSR R R +ER R +RS+SR+ KR RR SR
Sbjct: 16 GRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRE 75
Query: 57 RSRSTNTAVSR-RERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRK 115
R RS SR R+R R R+ S R R+ S + + + R ++K + K
Sbjct: 76 RDRSRERRRSRSRDRRRSRSRSRGRR----SRSSSPGNKSKKTENRSRSKEKTDGGESSK 131
Query: 116 IRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEK--QLL 173
++++ ++K E+E + ++EEE+ KRK+ +E+ R E+ K+ ME +L
Sbjct: 132 EKKKDKDDK--EDEKEKDAGNFDQNKLEEEMRKRKERVEK---WREEQRKKAMENIGELK 186
Query: 174 EELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKI 233
+E+E +Q +K E++ ++ +E N E L + EE +K
Sbjct: 187 KEIEEMKQ----GKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKF 242
Query: 234 HEERMK 239
+ +K
Sbjct: 243 NMRSVK 248
Score = 52.4 bits (124), Expect = 4e-07
Identities = 59/236 (25%), Positives = 89/236 (37%), Gaps = 50/236 (21%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERA 75
+ S+H +KRS SR RS + R R S R SKR R SRSR R RRER R R
Sbjct: 3 RESRHYRKRSASRGRSGSRSRSRSPSDKR-SKRGDDRRSRSRDRDR-----RRERSRSR- 55
Query: 76 SSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVE 135
KR S +KR + E +R R+ R+ ++ +R
Sbjct: 56 --------------DKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRG-- 99
Query: 136 ELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEER 195
RR + + + E R ++ + ++E+++
Sbjct: 100 -----------------------RRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKD 136
Query: 196 AKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
+E E+ + N Q KL EE + E K EE+ K E + K+E
Sbjct: 137 KDDKEDEKEKDAGNFD----QNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKE 188
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 89.4 bits (220), Expect = 3e-18
Identities = 64/242 (26%), Positives = 119/242 (49%), Gaps = 10/242 (4%)
Query: 32 RDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERA----SSPPDRIDIFGR 87
RD+ R+ + +R R+ R T S E + E P +++ G
Sbjct: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE 349
Query: 88 TVSKRSSL---DEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEE 144
+ +R L E ++R E ++ + +++++R+QE ++ + E +R+E+ +R
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 145 ELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREE--LE 202
E ++R++ R R + + EK+ LEELER+R+ E ++A EE+ R +RE+ +
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR 469
Query: 203 RILEENNRKIAEAQAKLAEEQLRIVE-EQRKIHEERMKLEQERQRQQKEEQKIILGKGKS 261
R LEE R + Q +L +EQ ++E R++ E R +RQ QQ++ + L
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHR 529
Query: 262 RP 263
RP
Sbjct: 530 RP 531
Score = 58.9 bits (141), Expect = 5e-09
Identities = 61/223 (27%), Positives = 100/223 (44%), Gaps = 61/223 (27%)
Query: 8 SSSRSKHTKSSKHNKKRSRSRSRS--------RDKERVRK-----RSKSRESKRNRRRES 54
S+ R + + NK+RS + R R++E ++ R K E ++ +RR
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 55 RSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQR 114
+ R A RR+++R E+++RE+EEK+
Sbjct: 410 EEQQRREREA--RRQQER------------------------EQRRREQEEKR------- 436
Query: 115 KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRR-VEEAKRIMEKQLL 173
R +E+E + EEE RR EE EKR+ E E+E +RR +EE +R +E +L
Sbjct: 437 --RLEELERRRKEEEERRRAEE----------EKRRVEREQEYIRRQLEEEQRHLE--VL 482
Query: 174 EELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
++ Q QA L + RE EE + E L+R L++ + Q
Sbjct: 483 QQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQ 525
Score = 46.6 bits (109), Expect = 2e-05
Identities = 42/175 (24%), Positives = 82/175 (46%), Gaps = 27/175 (15%)
Query: 113 QRKIRQQEIEEKLIEEE-TARRVEELVAKRVEEELEKR--KDEIEREVLRRVEEAKRIME 169
QR +Q ++ I ++ R+V + ++ +KR KDE E E EE + + E
Sbjct: 276 QRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPE 335
Query: 170 KQ--------------------LLEELERQRQAELAAQKAREEEERAKREELERILEENN 209
++ L++ ++R L Q+ +E++ ++EE +R L
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAER 395
Query: 210 RKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
+K E Q +EQ R +EEQ++ E + ++ QR++++E+K L + + R K
Sbjct: 396 QKRIEQQ----KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRK 446
Score = 28.9 bits (63), Expect = 5.0
Identities = 42/189 (22%), Positives = 65/189 (34%), Gaps = 33/189 (17%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R S S S + S S+S S ++ RVR SKS S S+ A
Sbjct: 752 RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSP----------SQRLENA 801
Query: 65 VSRRERDRE--RASSPPDRIDIFGRTVSKRSSLDEKQKRE-------EEEKKAEFERQRK 115
V + E +E R P +D+ R+ D + + EE E
Sbjct: 802 VKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDD 861
Query: 116 IRQQEIEEKLIEEETARRVEELVAKRVEEELEKR---KDEIERE-----------VLRRV 161
+ Q+ +E E R L E E K D++E E ++R+
Sbjct: 862 VEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQT 921
Query: 162 EEAKRIMEK 170
+ A ++K
Sbjct: 922 QSASSTLQK 930
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 89.0 bits (219), Expect = 4e-18
Identities = 58/197 (29%), Positives = 99/197 (50%), Gaps = 12/197 (6%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R R+ + S+ +++R R R+R RD++R R++ RE +R R RE R R R
Sbjct: 29 RERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERE-RDRDRQRE 87
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
T RERD+ER + DR T + R +K++ E + E E+Q+++ ++
Sbjct: 88 T---ERERDKERET---DR-----HTETDRERQKQKEREMERVRDREREKQKEMGRERQT 136
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
++ + E R+ E E + E R E ERE R E + E++ ++ER+RQ
Sbjct: 137 DRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDMERERQR 196
Query: 183 ELAAQKAREEEERAKRE 199
E ++ R+ E +R+
Sbjct: 197 ETDRKRDRQRESERERD 213
Score = 80.9 bits (198), Expect = 1e-15
Identities = 70/249 (28%), Positives = 121/249 (48%), Gaps = 51/249 (20%)
Query: 6 SRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRK-RSKSRESKRNRRRESRSRSRSTNTA 64
S++ R HT++ +++R R R R+++R ++ +++ R S+R+R+R+ R R+R
Sbjct: 3 SKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRD-RERNR----- 56
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
R+RDRER EKQ E E++ E ER R +++ E+
Sbjct: 57 --ERDRDRER----------------------EKQTDREGERQRERERDRDRQRETERER 92
Query: 125 LIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL 184
E ET R E + E +K+K ERE + RV + +R EKQ +E+ R+RQ +
Sbjct: 93 DKERETDRHTE------TDRERQKQK---ERE-MERVRDRER--EKQ--KEMGRERQTDR 138
Query: 185 AAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQER 244
+ RE + +RE RK + + E+ R E +R+ E + ER
Sbjct: 139 ETDRERERQAERERE------TGRERKTEDRHRERERERKRERERKRETKERERHTDMER 192
Query: 245 QRQQKEEQK 253
+RQ++ ++K
Sbjct: 193 ERQRETDRK 201
Score = 65.5 bits (158), Expect = 5e-11
Identities = 56/201 (27%), Positives = 94/201 (46%), Gaps = 16/201 (7%)
Query: 53 ESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER 112
ES++ R T+T +R RER DR R +K S ++ + E +++ + ER
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRE-TDR----ERDRAKESKTED--RHSERDRQRDRER 54
Query: 113 QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQL 172
R+ + EK + E R+ E + + E E+ +D+ ERE R E R +KQ
Sbjct: 55 NRERDRDREREKQTDREGERQRERERDRDRQRETERERDK-ERETDRHT-ETDRERQKQK 112
Query: 173 LEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRK 232
E+ER R E QK E + + +R + + AE + + E R E++ +
Sbjct: 113 EREMERVRDREREKQK-----EMGRERQTDRETDRERERQAERERETGRE--RKTEDRHR 165
Query: 233 IHEERMKLEQERQRQQKEEQK 253
E K E+ER+R+ KE ++
Sbjct: 166 ERERERKRERERKRETKERER 186
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/130 (21%), Positives = 61/130 (46%), Gaps = 11/130 (8%)
Query: 142 VEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREEL 201
+E + E R E E + R E +R ++ E +R ++++ + + + +R +
Sbjct: 1 MESKTEGRHTHTETETMDRQRERRRETDR----ERDRAKESKTEDRHSERDRQRDRERNR 56
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMK-------LEQERQRQQKEEQKI 254
ER + K + + + E+ R + QR+ ER K E +R+RQ+++E+++
Sbjct: 57 ERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREM 116
Query: 255 ILGKGKSRPK 264
+ + R K
Sbjct: 117 ERVRDREREK 126
Score = 37.7 bits (86), Expect = 0.011
Identities = 31/120 (25%), Positives = 53/120 (44%), Gaps = 4/120 (3%)
Query: 143 EEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEE-ERAKREEL 201
E E R+ E RE R + AK + E +RQR E ++ R+ E E+ E
Sbjct: 13 ETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREG 72
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL---EQERQRQQKEEQKIILGK 258
ER E + + + + ++ R + + ER K E ER R ++ E++ +G+
Sbjct: 73 ERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGR 132
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 87.0 bits (214), Expect = 2e-17
Identities = 61/252 (24%), Positives = 134/252 (53%), Gaps = 14/252 (5%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R R + K + +K R + ++E++R+ K +E + R+E + R +
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE--I 538
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124
++E+ E+ + + R K +EK RE+EEK + ++ KIR+QE EK
Sbjct: 539 WRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKI-REQEEKV--WRQEEKIREQE--EK 593
Query: 125 LIEEETARRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQA 182
+ E+E R +E + + EE++ ++++++ + E ++ EE R E+++ E+ ++ R+
Sbjct: 594 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ 653
Query: 183 ELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQ 242
E +K RE+EE +E E + E K+ E + K+ E++ ++ ++ K+ E+ ++L Q
Sbjct: 654 E---EKIREQEE--MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 708
Query: 243 ERQRQQKEEQKI 254
+ ++ Q+ ++ +
Sbjct: 709 QEEKMQEHQEHL 720
Score = 85.5 bits (210), Expect = 5e-17
Identities = 61/237 (25%), Positives = 127/237 (53%), Gaps = 16/237 (6%)
Query: 30 RSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTV 89
+ ++E++R++ + R+ + + RE R + E+ RE+ ++ + R
Sbjct: 446 KMHEQEKIREQEEKRQEEE-KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 90 SKRSSLDEKQKREEEEKKAEFE----RQRKIRQQE----IEEKLIEEETARRVEELVAKR 141
K + E++K EEEK+ E E ++ KIR+QE +EK+ E+E R +E R
Sbjct: 505 EK---IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWR 561
Query: 142 VEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREE--EERAK 197
EE++ ++++I + E + R EE R E+++ E+ E+ R+ E Q+ E+ E+ K
Sbjct: 562 QEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 621
Query: 198 REELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E E ++E K+ + K+ E++ +I E++ KI E+ ++++ ++ ++E+K+
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 678
Score = 84.7 bits (208), Expect = 8e-17
Identities = 63/255 (24%), Positives = 132/255 (51%), Gaps = 27/255 (10%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R + K + K R + + + ++ + R+ K RE + R + R + +E+
Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEK-IHEQEK 512
Query: 71 DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEE----KKAEFERQRKIRQQEI----- 121
RE R + E++ RE+EE K+ E++ KIR+QE
Sbjct: 513 IREEEK----------RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ 562
Query: 122 EEKLIEEETARRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQ 179
EEK+ ++E R +E R EE++ +++++I + E +R EE + E+++ E+ E+
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 622
Query: 180 RQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMK 239
+ E +K +E+EE+ +R+E + + E +KI E + K+ E++ + E++ K+ E+ K
Sbjct: 623 CEQE---EKMQEQEEKMRRQEEK--IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677
Query: 240 LEQERQRQQKEEQKI 254
+ ++ ++ Q++E+K+
Sbjct: 678 MCEQEEKMQEQEEKM 692
Score = 79.3 bits (194), Expect = 3e-15
Identities = 55/269 (20%), Positives = 134/269 (49%), Gaps = 20/269 (7%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + K K R + +E++R++ + K + RE +
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 451
Query: 63 TAVSRRER--DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
+ E+ + E+ R + + + + E++++ E+++ + ++ KI +QE
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511
Query: 121 I----EEKLIEEETARRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLE 174
E++ +EE R+ E++ R +EE+ ++K++I + E +R+ EE E+++ +
Sbjct: 512 KIREEEKRQEQEEMWRQEEKI---REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 175 ELERQRQAE----LAAQKAREEEERAKRE-----ELERILEENNRKIAEAQAKLAEEQLR 225
+ E+ R+ E +K RE+EE+ + + E E + +E K+ E + K+ E++ +
Sbjct: 569 QEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628
Query: 226 IVEEQRKIHEERMKLEQERQRQQKEEQKI 254
+ E++ K+ + K+ ++ ++ +++E+KI
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKI 657
Score = 77.4 bits (189), Expect = 1e-14
Identities = 57/237 (24%), Positives = 120/237 (50%), Gaps = 14/237 (5%)
Query: 32 RDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSK 91
R +E++++ + + + + RE + R + R+E R + +
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 424
Query: 92 RSSLDEKQKREEEEKKAEFER----QRKIRQQEI---EEKLIEEETARRVEELVAKRVEE 144
+ E+ E+EEK E E Q KIR+QE EE+ I E+ R+ +E R EE
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 484
Query: 145 ELEKRKDEIEREVLRRVEEAKRIMEKQLL-EELERQRQAELAAQ--KAREEEE----RAK 197
++ +++++I + + + ++I E++ + EE +RQ Q E+ Q K RE+EE + K
Sbjct: 485 KIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 544
Query: 198 REELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E E + + K+ + K+ +++ +I E++ K+ + K+ ++ ++ +++E+KI
Sbjct: 545 IHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Score = 77.4 bits (189), Expect = 1e-14
Identities = 53/243 (21%), Positives = 122/243 (50%), Gaps = 14/243 (5%)
Query: 19 KHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSP 78
+ K R + +E++R++ + K + R + R+E E
Sbjct: 380 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE---EMMWEK 436
Query: 79 PDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELV 138
++I R + ++ EK + +EE+++ E + + + ++QE E K+ +E R +E
Sbjct: 437 EEKI----RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 492
Query: 139 AKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAR--EEEERA 196
+ EE++ +++++I + R EE ++ E+ +E + + Q E+ QK + E+EE+
Sbjct: 493 IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKI 552
Query: 197 KREE-----LERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
+++E E + + KI E + K+ ++ +I E++ KI E+ K+ ++ + Q++E
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612
Query: 252 QKI 254
+K+
Sbjct: 613 EKM 615
Score = 76.3 bits (186), Expect = 3e-14
Identities = 69/258 (26%), Positives = 130/258 (50%), Gaps = 39/258 (15%)
Query: 28 RSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRI----D 83
R+ D+E K +K +E + + ES N +R+ +R + P ++ D
Sbjct: 272 RNTITDEELKEKNAKLQE--KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 329
Query: 84 IFGRTVSKRSSLDEKQKREEE--------EKKAEFERQRKIRQ-----QEIEEKLIEEET 130
G+ + S+ + Q E E +++ + ++ KI++ QE EEK+ E+E
Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 389
Query: 131 ARRVEELVAKRVEEELEKRKDEIER--EVLRRVEEAKRIMEKQLLEELERQRQAELAA-- 186
R +E +R EE + ++++++ R E++ EE R E+ + E+ E+ R+ E
Sbjct: 390 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449
Query: 187 -QKAREEEERAKREELERILEENNR------------KIAEAQAKLAEEQLRIVEEQRKI 233
+K RE+EE KR+E E+I E+ R KI E + K+ E++ ++ ++ KI
Sbjct: 450 QEKIREQEE--KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507
Query: 234 HEERMKLEQERQRQQKEE 251
HE+ K+ +E +RQ++EE
Sbjct: 508 HEQE-KIREEEKRQEQEE 524
Score = 74.7 bits (182), Expect = 8e-14
Identities = 64/264 (24%), Positives = 126/264 (47%), Gaps = 32/264 (12%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKS----RESKRNRRRESRSRSRSTNTAVS 66
R + K + +K R +KE +R + +E K R+ E +
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 444
Query: 67 RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI 126
+ ++E+ ++ + + E++KR+E+E K + ++ KIR+QE EK+
Sbjct: 445 EKMHEQEKIREQEEKRQ-------EEEKIREQEKRQEQEAKM-WRQEEKIREQE--EKIR 494
Query: 127 EEETA--RRVEELVAKRVEEELEKRKDEIE----REVLRRVEEAKRIMEKQLLEELERQR 180
E+E R+ E++ + E EKR+++ E E +R EE R EK +E + ++
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRK 554
Query: 181 QAEL----------AAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQ 230
Q E +K RE+EE+ R+E + + E KI E + K+ E++ E++
Sbjct: 555 QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEK--IREQEEKIREQEEKIREQEEMTQEQE 612
Query: 231 RKIHEERMKLEQERQRQQKEEQKI 254
K+ E+ K+ ++ ++ Q++E+K+
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKM 636
Score = 59.3 bits (142), Expect = 3e-09
Identities = 47/195 (24%), Positives = 96/195 (49%), Gaps = 14/195 (7%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKE-RVRKRSKSRESKRNRRRESRSRSRSTNT 63
R + + K K +K R + D+E ++R++ + + + RE + R
Sbjct: 540 RQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIRE--- 596
Query: 64 AVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEE 123
+ E+ RE+ ++ + G K +EK + +EE+ + + E KIR+Q E+
Sbjct: 597 ---QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEE---KIREQ--EK 648
Query: 124 KLIEEETARRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQ 181
K+ E+E R +E + + EE++ ++++++ + E ++ EE R E+++ E+ R RQ
Sbjct: 649 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 708
Query: 182 AELAAQKAREEEERA 196
E Q+ +E E A
Sbjct: 709 QEEKMQEHQEHLEAA 723
Score = 49.7 bits (117), Expect = 3e-06
Identities = 40/155 (25%), Positives = 78/155 (50%), Gaps = 10/155 (6%)
Query: 102 EEEEKKAEFERQRKIRQQEIEEKLIE---EETARRVEELVAKRVEEELEKRKDEIEREVL 158
+EE K+ + Q K++ E E+ I+ +E R++E +++L+ D + +E+
Sbjct: 277 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 336
Query: 159 RRVEEAK-RIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQA 217
+ + ++ E +L L +Q++ ++ Q+ + +E K +E E + E KI E
Sbjct: 337 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ-- 394
Query: 218 KLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQ 252
EE++R EE EE+M+ QE +KEE+
Sbjct: 395 ---EEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEK 425
Score = 46.6 bits (109), Expect = 2e-05
Identities = 33/158 (20%), Positives = 81/158 (51%), Gaps = 6/158 (3%)
Query: 99 QKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIE---R 155
QK++ + E ++R E+ I +E + + ++++ +E K EI+ +
Sbjct: 248 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL-VESEKSEIQLNVK 306
Query: 156 EVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEA 215
E+ R++E AK ++ +Q L+ EL + A+ + + + E R+ ++ K+
Sbjct: 307 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 366
Query: 216 QAKLAEEQLRIVEEQRK-IHEERMKLEQERQRQQKEEQ 252
+ K+ E + +I +EQ + I E+ K+ ++ ++ +++E+
Sbjct: 367 EEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEE 403
Score = 38.9 bits (89), Expect = 0.005
Identities = 31/172 (18%), Positives = 71/172 (41%), Gaps = 17/172 (9%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + + K R + R +E++R++ + + + RE ++
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE 612
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAE------------F 110
+ +E + R ++ EK+ RE+EEK E +
Sbjct: 613 EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 672
Query: 111 ERQRKI-----RQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREV 157
E++ K+ + QE EEK+ +E +E+ ++ EE++++ ++ +E +
Sbjct: 673 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 87.0 bits (214), Expect = 2e-17
Identities = 80/290 (27%), Positives = 131/290 (45%), Gaps = 62/290 (21%)
Query: 23 KRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRI 82
+ R++ RSRD+++ RK RE + NRR++ +++ D E SS ++
Sbjct: 42 REERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASD--------DEEDVSSKVEKA 93
Query: 83 DI--FGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEEL--- 137
+ TV R + EKQ++EE+ K+ E ER+R+I Q +E++ I+ E A+R E++
Sbjct: 94 YVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDI 153
Query: 138 ------------------------------VAKRVEEELEKRKDEIEREVLRRVEEAKRI 167
K+ E+LEK ++E ER + EE KRI
Sbjct: 154 NNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKER---IKYEEDKRI 210
Query: 168 MEKQLLEELERQRQAELAAQKAREEEERAKR----------EELERILEENNRKIAEAQA 217
++ L+ + L E E + + EELER +EN +K AE +A
Sbjct: 211 RYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA 270
Query: 218 KLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSF 267
+ R+ EE+R E R ++ E + Q + KI G + KLSF
Sbjct: 271 R-----KRLEEEKRAFEEARRQMVNEDEENQ-DTAKIFKGYRPGKLKLSF 314
Score = 63.5 bits (153), Expect = 2e-10
Identities = 62/252 (24%), Positives = 115/252 (45%), Gaps = 44/252 (17%)
Query: 39 KRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDE- 97
+R + + KR E+R R A + R+ P+ + L+
Sbjct: 318 ERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEIN 377
Query: 98 -----KQKREEEEKKAEFERQRKIR---------QQEIEEKLIEEET---ARRVEELV-- 138
KQK EEE+++ E ER+ K+ +QE+ E+ E ET +R EEL+
Sbjct: 378 FEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKL 437
Query: 139 -------AKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE 191
AK ++ + EK E+E+ +++EE + ++ ++ ++R+AE ++
Sbjct: 438 KRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEER--ARRRAIDLEIKEREAENFHEEDDV 495
Query: 192 EEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEE---RMKLEQ------ 242
+ A++ E + N + E AK EE EEQR+I E+ RM+ EQ
Sbjct: 496 DVRPARKSEAPFTHKVNMKARFEQMAKAREE-----EEQRRIEEQKLLRMQFEQREIDAA 550
Query: 243 -ERQRQQKEEQK 253
+++R+++EE++
Sbjct: 551 LQKKREEEEEEE 562
Score = 58.2 bits (139), Expect = 8e-09
Identities = 79/326 (24%), Positives = 125/326 (38%), Gaps = 92/326 (28%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRS-------- 56
+ R + K T+ + + + + + + KR++ E N ES S
Sbjct: 111 KQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLL 170
Query: 57 ------RSRSTNTAVSRRERDRERASSPPDRI----DIFGRTVSKRSSLDEKQ------- 99
+S T+ + + D E+ +RI D R +R SL E +
Sbjct: 171 ITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMD 230
Query: 100 -KREEEEKKA------------EFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEEL 146
+ E E KK E ERQR QE +K EEE +R+EE KR EE
Sbjct: 231 DEIESEAKKESLSPGKLKLTFEELERQR----QENRKKQAEEEARKRLEE--EKRAFEEA 284
Query: 147 EKR---KDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELER 203
++ +DE ++ + + + K EE+ERQR RE+E+R EE R
Sbjct: 285 RRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQR---------REDEKRKAEEEARR 335
Query: 204 ILEENNRKIAEAQAKLA----------------------------------EEQLRIVEE 229
+EE + AEA+ + EE+ R EE
Sbjct: 336 RIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEE 395
Query: 230 QR--KIHEERMKLEQERQRQQKEEQK 253
+R K+ E+ + EQ RQ +EE++
Sbjct: 396 ERKHKLEMEKQEFEQLRQEMGEEEEE 421
Score = 36.2 bits (82), Expect = 0.032
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 19/159 (11%)
Query: 23 KRSRSRSRSRDKERVRKRSKSRESKRNRR-RESRSRSRSTNTAVSRRERDRERASSPPDR 81
KRS S K + K + E + ++ E R+R R+ + + RE + D
Sbjct: 438 KRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEE---DD 494
Query: 82 IDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKR 141
+D+ + + E + KA FE+ K R EEE RR+EE R
Sbjct: 495 VDV------RPARKSEAPFTHKVNMKARFEQMAKAR---------EEEEQRRIEEQKLLR 539
Query: 142 VEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR 180
++ E + ++++ EE IM E+ E+ R
Sbjct: 540 MQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTR 578
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 86.7 bits (213), Expect = 2e-17
Identities = 58/205 (28%), Positives = 103/205 (50%), Gaps = 13/205 (6%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + S+ K + +KR R R + R +ER +K K K R R+ R R +
Sbjct: 48 RKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENK 107
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
E+++ + +R GRT + + K++R+ EE+K E ER+++ R++E E
Sbjct: 108 EG---EEKEKRKKKEKKER----GRTSKEGKERERKEERKREERK-ERERKKEEREKERE 159
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
K ++ ++V E +R E+E ++RK ER R +E +R ++ +E +++ +
Sbjct: 160 RKERKKRERKQVGEKEEERKEKERKERKKR-ERNRKERKKERERKERRERKKERKKKEER 218
Query: 183 ELAAQKARE----EEERAKREELER 203
+ QK R+ E+ER KRE ER
Sbjct: 219 KKERQKDRQTNWREKERGKRERKER 243
Score = 84.7 bits (208), Expect = 8e-17
Identities = 68/230 (29%), Positives = 116/230 (50%), Gaps = 31/230 (13%)
Query: 24 RSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRID 83
+S R R R+ E ++ K RES+R + R R + + RER++ER
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRK--------REREKERK-------- 78
Query: 84 IFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVE 143
R K+ E++K E E KK E++ K +++ + K E++ R + +R
Sbjct: 79 ---RERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER 135
Query: 144 EELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELER 203
+E KR++ ERE R+ EE ++ E++ E +R+R+ Q +EEER ++E ER
Sbjct: 136 KEERKREERKERE--RKKEEREK--ERERKERKKRERK-----QVGEKEEERKEKERKER 186
Query: 204 ILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
E NRK + + + E + R +++RK EER K E+++ RQ +K
Sbjct: 187 KKRERNRKERKKERERKERRER--KKERKKKEERKK-ERQKDRQTNWREK 233
Score = 72.4 bits (176), Expect = 4e-13
Identities = 56/239 (23%), Positives = 114/239 (47%), Gaps = 29/239 (12%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKSR-ESKRNRRRESRSRSRSTNTAVSRRERDRER 74
+S ++R + KER +R K R E ++ +R + R R + ER +E
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 75 ASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRV 134
+K++RE+E K+ E + +RK ++++ + +E R
Sbjct: 95 RER-------------------KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER 135
Query: 135 EELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEE 194
+E + +E E++K+E E+E R +E K+ KQ+ E+ E +++ E +K RE
Sbjct: 136 KEERKREERKERERKKEEREKE--RERKERKKRERKQVGEKEEERKEKERKERKKRERNR 193
Query: 195 RAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
+ +++E ER R+ + + K EE+ + E++K + + ++ +R++KE +K
Sbjct: 194 KERKKERER----KERRERKKERKKKEERKK---ERQKDRQTNWREKERGKRERKERKK 245
Score = 62.0 bits (149), Expect = 5e-10
Identities = 46/168 (27%), Positives = 92/168 (54%), Gaps = 11/168 (6%)
Query: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIERE 156
E++ +E K E E +RK ++E E++ E E R+ E + E++ E++K+E ER+
Sbjct: 42 EREIETRKEGKKERESERKKERREREKRKREREKERKRER---GKKEKKGERKKEERERK 98
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
RR +E K EK+ ++ E++ + + ++E +ER ++EE +R + + E +
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERG----RTSKEGKERERKEERKREERKERERKKEER 154
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
K E + R E++++ E+ E+ER+ ++++E+K K R K
Sbjct: 155 EKERERKERKKRERKQVGEK----EEERKEKERKERKKRERNRKERKK 198
Score = 54.3 bits (129), Expect = 1e-07
Identities = 28/119 (23%), Positives = 54/119 (45%), Gaps = 14/119 (11%)
Query: 2 GRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRST 61
G+ R R R + + + KK R + R R + + R+R + E + R+ + R +
Sbjct: 130 GKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKR 189
Query: 62 NTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
R+++RER +R E++K+EE +K+ + +RQ R++E
Sbjct: 190 ERNRKERKKERERK--------------ERRERKKERKKKEERKKERQKDRQTNWREKE 234
Score = 53.1 bits (126), Expect = 2e-07
Identities = 31/134 (23%), Positives = 64/134 (47%), Gaps = 3/134 (2%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRST- 61
+ + + + + ++SK K+R R R R++ + R+R K K R+E + R R
Sbjct: 112 KEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQV 171
Query: 62 -NTAVSRRERDR-ERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQ 119
R+E++R ER +R + K +K+++++EE+K E ++ R+ +
Sbjct: 172 GEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWR 231
Query: 120 EIEEKLIEEETARR 133
E E E + ++
Sbjct: 232 EKERGKRERKERKK 245
Score = 50.8 bits (120), Expect = 1e-06
Identities = 41/147 (27%), Positives = 77/147 (52%), Gaps = 16/147 (10%)
Query: 118 QQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELE 177
Q EI E+ E ET + ++ E E E++K+ ERE +R E +R E+ E+
Sbjct: 35 QSEIREREREIETRKEGKK------ERESERKKERREREKRKREREKERKRERGKKEKKG 88
Query: 178 RQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
+++ E +K R E+E + EE E+ +K + + + ++E ++R+ EER
Sbjct: 89 ERKKEERERKKRRREKENKEGEEKEK----RKKKEKKERGRTSKEG-----KERERKEER 139
Query: 238 MKLEQERQRQQKEEQKIILGKGKSRPK 264
K E+ ++R++K+E++ + K R K
Sbjct: 140 -KREERKERERKKEEREKERERKERKK 165
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/270 (25%), Positives = 129/270 (47%), Gaps = 29/270 (10%)
Query: 3 RSRSRSSSRSKHT--KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
+S SRSS K+T +SSK + RS +K ++ +++ + + S
Sbjct: 458 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 517
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRT------VSKRSSLDEKQKREEEEKKAEFERQR 114
T+ ++ + E + +S P + I +T S+R ++ R +E+++A +++R
Sbjct: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKR 577
Query: 115 -------------KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV 161
K+++Q + E L+ E RR EL +R E E+R+ E R ++R
Sbjct: 578 DKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIR-IIRER 636
Query: 162 EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
EE +R+ ++ E+ERQ+ ++ R E ER +RE + +E+ RK AE A+ E
Sbjct: 637 EERERLQRERERLEIERQK-----LERERMERERLERERIR--IEQERRKEAERIARERE 689
Query: 222 EQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
E R ++ R E+R L++ R + +
Sbjct: 690 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRD 719
Score = 84.3 bits (207), Expect = 1e-16
Identities = 71/278 (25%), Positives = 132/278 (47%), Gaps = 39/278 (14%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSR------SRS 60
+SSSRS K + ++ S ++++R ++S+ +ESK ++ E + S
Sbjct: 458 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 517
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTV------SKRSSLDEKQKREEEEKKAEFERQR 114
T+ ++ + E + +S P + I +T S+R ++ R +E+++A +++R
Sbjct: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKR 577
Query: 115 -------------KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV 161
K+++Q + E L+ E RR EL +R E E+R+ E R ++R
Sbjct: 578 DKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIR-IIRER 636
Query: 162 EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
EE +R+ ++ E+ERQ+ ++ R E ER +RE + +E+ RK AE A+ E
Sbjct: 637 EERERLQRERERLEIERQK-----LERERMERERLERERIR--IEQERRKEAERIARERE 689
Query: 222 E------QLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
E QLR +E+R + ++ R E K
Sbjct: 690 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENK 727
Score = 47.0 bits (110), Expect = 2e-05
Identities = 58/261 (22%), Positives = 106/261 (40%), Gaps = 76/261 (29%)
Query: 66 SRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQ------ 119
S++E +E R + S RSS + ++EE++ +E +++ +
Sbjct: 447 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 506
Query: 120 ----------EIEEKLIEEETARRV---------------------------EELVAKRV 142
+ E + + E +R+ E++ +
Sbjct: 507 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 566
Query: 143 EEE-------------------LEKRKDEIEREVLRRVEEAKRIME---KQLLEELERQR 180
E+E EK K++ RE L R E +R ME ++ + E ER+
Sbjct: 567 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRE 626
Query: 181 QAELAAQKAREEEERAKRE----ELERILEENNRKIAEAQAKLAEEQLRIVEEQRK---- 232
+ + + REE ER +RE E+ER E R E +L E++RI +E+RK
Sbjct: 627 RERIRIIREREERERLQRERERLEIERQKLERERMERE---RLERERIRIEQERRKEAER 683
Query: 233 IHEERMKLEQERQRQQKEEQK 253
I ER +L +++Q+ + E++K
Sbjct: 684 IAREREELRRQQQQLRYEQEK 704
Score = 37.0 bits (84), Expect = 0.018
Identities = 44/176 (25%), Positives = 68/176 (38%), Gaps = 20/176 (11%)
Query: 65 VSRRERDRERASSPPDRID--IFGRTVSKRSSLDEKQKREEEE-------------KKAE 109
+SR ++ E PD I+ + T +K+ + + +K E +E K E
Sbjct: 49 ISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCE 108
Query: 110 FERQRKIRQQEIEEKLIEEETARRVEELVAKRV---EEELEKRKDEIEREVLRRVEEAKR 166
E Q Q +E EE EE V + EE ++ + IE E + +E K
Sbjct: 109 LENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIE--KE 166
Query: 167 IMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEE 222
+E Q +E E + L AQ EEE + E + A K AE+
Sbjct: 167 DIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAED 222
Score = 29.6 bits (65), Expect = 3.0
Identities = 19/62 (30%), Positives = 27/62 (43%)
Query: 23 KRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRI 82
K++R +R D R +S+RN R+ R ++ R ERD R DR
Sbjct: 785 KKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRP 844
Query: 83 DI 84
DI
Sbjct: 845 DI 846
>gi|63176611 modulator of estrogen induced transcription isoform a
[Homo sapiens]
Length = 1034
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/270 (25%), Positives = 129/270 (47%), Gaps = 29/270 (10%)
Query: 3 RSRSRSSSRSKHT--KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
+S SRSS K+T +SSK + RS +K ++ +++ + + S
Sbjct: 476 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 535
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRT------VSKRSSLDEKQKREEEEKKAEFERQR 114
T+ ++ + E + +S P + I +T S+R ++ R +E+++A +++R
Sbjct: 536 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKR 595
Query: 115 -------------KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV 161
K+++Q + E L+ E RR EL +R E E+R+ E R ++R
Sbjct: 596 DKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIR-IIRER 654
Query: 162 EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
EE +R+ ++ E+ERQ+ ++ R E ER +RE + +E+ RK AE A+ E
Sbjct: 655 EERERLQRERERLEIERQK-----LERERMERERLERERIR--IEQERRKEAERIARERE 707
Query: 222 EQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
E R ++ R E+R L++ R + +
Sbjct: 708 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRD 737
Score = 84.3 bits (207), Expect = 1e-16
Identities = 71/278 (25%), Positives = 132/278 (47%), Gaps = 39/278 (14%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSR------SRS 60
+SSSRS K + ++ S ++++R ++S+ +ESK ++ E + S
Sbjct: 476 KSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQ 535
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTV------SKRSSLDEKQKREEEEKKAEFERQR 114
T+ ++ + E + +S P + I +T S+R ++ R +E+++A +++R
Sbjct: 536 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKR 595
Query: 115 -------------KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRV 161
K+++Q + E L+ E RR EL +R E E+R+ E R ++R
Sbjct: 596 DKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIR-IIRER 654
Query: 162 EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
EE +R+ ++ E+ERQ+ ++ R E ER +RE + +E+ RK AE A+ E
Sbjct: 655 EERERLQRERERLEIERQK-----LERERMERERLERERIR--IEQERRKEAERIARERE 707
Query: 222 E------QLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
E QLR +E+R + ++ R E K
Sbjct: 708 ELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENK 745
Score = 47.0 bits (110), Expect = 2e-05
Identities = 58/261 (22%), Positives = 106/261 (40%), Gaps = 76/261 (29%)
Query: 66 SRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQ------ 119
S++E +E R + S RSS + ++EE++ +E +++ +
Sbjct: 465 SKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGK 524
Query: 120 ----------EIEEKLIEEETARRV---------------------------EELVAKRV 142
+ E + + E +R+ E++ +
Sbjct: 525 DEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSK 584
Query: 143 EEE-------------------LEKRKDEIEREVLRRVEEAKRIME---KQLLEELERQR 180
E+E EK K++ RE L R E +R ME ++ + E ER+
Sbjct: 585 EKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRE 644
Query: 181 QAELAAQKAREEEERAKRE----ELERILEENNRKIAEAQAKLAEEQLRIVEEQRK---- 232
+ + + REE ER +RE E+ER E R E +L E++RI +E+RK
Sbjct: 645 RERIRIIREREERERLQRERERLEIERQKLERERMERE---RLERERIRIEQERRKEAER 701
Query: 233 IHEERMKLEQERQRQQKEEQK 253
I ER +L +++Q+ + E++K
Sbjct: 702 IAREREELRRQQQQLRYEQEK 722
Score = 29.6 bits (65), Expect = 3.0
Identities = 19/62 (30%), Positives = 27/62 (43%)
Query: 23 KRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRI 82
K++R +R D R +S+RN R+ R ++ R ERD R DR
Sbjct: 803 KKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRP 862
Query: 83 DI 84
DI
Sbjct: 863 DI 864
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/246 (28%), Positives = 120/246 (48%), Gaps = 14/246 (5%)
Query: 15 TKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRER 74
T ++ +K +S SR E + ++ ++N R++ + E +R
Sbjct: 141 TAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKR 200
Query: 75 ASSPPDRIDIFGRTVSKRS-------SLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIE 127
S +++++ + S SL Q EE K+ E ER++ + EK+ E
Sbjct: 201 GSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE-EREQGSDEISHHEKM-E 258
Query: 128 EETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQ 187
EE R E A+ EE E+ K E ++++ +E RI ++ ER+R+ +
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKI---ADERARIEAEEKAAAQERERREAEERE 315
Query: 188 KAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQ 247
+ REEE+RA EE +RI EE R AE + ++ EE+ R EE+++I EE + +ERQR
Sbjct: 316 RMREEEKRAA-EERQRIKEEEKR-AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRA 373
Query: 248 QKEEQK 253
+ EE++
Sbjct: 374 RAEEEE 379
Score = 85.9 bits (211), Expect = 3e-17
Identities = 75/286 (26%), Positives = 138/286 (48%), Gaps = 38/286 (13%)
Query: 24 RSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRID 83
R R + R +E + ++ + + + SR +TA + E++ S +R +
Sbjct: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYE 161
Query: 84 IFG-RTVSKRSSLD-----EKQKREEEEKKAEFERQRK---IRQQEIEEKLIEEETARRV 134
I TV+K + E+ K+E++EK+ E E + K I + ++E ++EE+T
Sbjct: 162 IEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEV-MVEEKTTESQ 220
Query: 135 EELVAKRV------------EEELEKRKDEI------EREVLRRVEEAKRIMEKQLLEEL 176
EE V + EEE E+ DEI E E R E + +E + E +
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
Query: 177 ERQRQAELAAQKAR---------EEEERAKREELERILEENNRKIAEAQAKLAEEQLRIV 227
+ ++ ++A ++AR +E ER + EE ER+ EE R AE + ++ EE+ R
Sbjct: 281 KAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRA-AEERQRIKEEEKRAA 339
Query: 228 EEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD 273
EE+++I EE + +ERQR ++EE++ + ++R + K ++
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385
Score = 79.0 bits (193), Expect = 4e-15
Identities = 70/259 (27%), Positives = 134/259 (51%), Gaps = 26/259 (10%)
Query: 8 SSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSR 67
S S H K + +K+R+ + R+R + R+R K+ + K+ +R + A R
Sbjct: 248 SDEISHHEKMEEEDKERAEAE-RARLEAEERERIKAEQDKKIADERARIEAEEKAAAQER 306
Query: 68 RERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE----IEE 123
R+ E R KR++ +E+Q+ +EEEK+A ERQR I+++E E
Sbjct: 307 ERREAEERERM--------REEEKRAA-EERQRIKEEEKRAAEERQR-IKEEEKRAAEER 356
Query: 124 KLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLL--EELERQRQ 181
+ I+EE R EE R EEE + + +E +R +++EE K M++ + E++E++ +
Sbjct: 357 QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRN--KQLEEKKHAMQETKIKGEKVEQKIE 414
Query: 182 AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLE 241
+ +K + +E++ + L++ EE K+ + KL E++ +E+ I +E++K
Sbjct: 415 GKWVNEK-KAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE--IKDEKIK-- 469
Query: 242 QERQRQQKEEQKIILGKGK 260
+ ++ KEE K + + K
Sbjct: 470 --KDKEPKEEVKSFMDRKK 486
Score = 76.6 bits (187), Expect = 2e-14
Identities = 68/251 (27%), Positives = 117/251 (46%), Gaps = 17/251 (6%)
Query: 15 TKSSKHNKKRSRSRSRSRDKERVR------KRSKSRESKRNRRRESRSRSRSTNTAVSRR 68
TKS + N R ++ DKE+ KR E++ E ++ T V
Sbjct: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
Query: 69 ERDRERASSPP--DRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI 126
+ + + P + + +S ++E+ K E ++A E + + R + ++K I
Sbjct: 229 KNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKI 288
Query: 127 EEETAR-RVEELVAKRVEEELE-KRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAEL 184
+E AR EE A + E E + ++ + E R EE +RI E++ ERQR E
Sbjct: 289 ADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE- 347
Query: 185 AAQKAREEEERAKREELERILEENNRKIAEAQAKL-AEEQLRIVEEQRKIHEERMKLEQE 243
++A EE +R K EE +R EE R AE + K EEQ R +++ E++ +++
Sbjct: 348 EEKRAAEERQRIKEEE-KRAAEERQRARAEEEEKAKVEEQKR----NKQLEEKKHAMQET 402
Query: 244 RQRQQKEEQKI 254
+ + +K EQKI
Sbjct: 403 KIKGEKVEQKI 413
Score = 75.1 bits (183), Expect = 6e-14
Identities = 69/245 (28%), Positives = 111/245 (45%), Gaps = 27/245 (11%)
Query: 43 SRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSK----RSSLDEK 98
S E K+ RE S S + + E D+ERA + R++ R K + DE+
Sbjct: 235 SEEPKQEEEREQGSDEISHHEKME--EEDKERAEAERARLEAEERERIKAEQDKKIADER 292
Query: 99 QKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVL 158
+ E EEK A ER+R R+ E E++ EEE E K E+ + + I+ E
Sbjct: 293 ARIEAEEKAAAQERER--REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 350
Query: 159 RRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKR--EELERILEE--------- 207
R EE +RI E++ ERQR +KA+ EE++ + EE + ++E
Sbjct: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
Query: 208 --------NNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKG 259
N +K E + + A + + E+ K+ +R KL++++ +KEE K K
Sbjct: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK 470
Query: 260 KSRPK 264
PK
Sbjct: 471 DKEPK 475
Score = 62.4 bits (150), Expect = 4e-10
Identities = 74/314 (23%), Positives = 140/314 (44%), Gaps = 72/314 (22%)
Query: 7 RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVR----KRSKSRESKRNRRRESRSRSRSTN 62
R++ + K + R R+R+ ++E+ + KR+K E K++ +E++ +
Sbjct: 351 RAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
Query: 63 -------------------TAVSRRERDRE--RASSPPDRIDIFGRTVSKRSSLDEKQKR 101
TAV +++ + + + + +++ T K DEK K+
Sbjct: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK 470
Query: 102 EEEEK---KAEFERQR---KIRQQEIE---------------------------EKLIEE 128
++E K K+ +R++ +++ Q E E +
Sbjct: 471 DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV 530
Query: 129 ETARRVEELVAKRVE---EELEKRKDEIEREVLRRVEEAKRIME--KQLLEELERQRQAE 183
E +R+EEL +R E EE EK K + ++E +EE K+ E +++LEE E++R+ E
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQK-QQEAALELEELKKKREERRKVLEEEEQRRKQE 589
Query: 184 LAAQKAREEEE-RAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER---MK 239
A +K REEEE R +EE+ER + AE + K+ E+ L ++ K + +K
Sbjct: 590 EADRKLREEEEKRRLKEEIER----RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLK 645
Query: 240 LEQERQRQQKEEQK 253
+E+ + K QK
Sbjct: 646 IEERAEFLNKSVQK 659
Score = 51.6 bits (122), Expect = 7e-07
Identities = 48/164 (29%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETAR-RVEELVAKRVEEELEKRKDEIER 155
E ++++ EE + E ER R + EE+ E R R E L K+ EE L + D++E
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68
Query: 156 EVLRRV--EEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKR--EELERILEENNRK 211
V EEAK ++E +A + AR EE R KR E LER +E +
Sbjct: 69 NAQNSVPDEEAKTTTTN---TQVEGDDEAAFLERLARREERRQKRLQEALER-QKEFDPT 124
Query: 212 IAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKII 255
I +A L +++ + + E+ K E ++R + EE + +
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETV 168
Score = 48.5 bits (114), Expect = 6e-06
Identities = 41/172 (23%), Positives = 81/172 (47%), Gaps = 22/172 (12%)
Query: 99 QKREEEEKKAEFERQRKIRQQEIEEKLIEE---ETARRVEELVAKRVEEELEKR------ 149
Q+ +++E++A ER+R+ RQ+ + +K EE + +VE V +E K
Sbjct: 28 QRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQ 87
Query: 150 -KDEIEREVLRRVEEAKRIMEKQLLEELERQRQ-------AELAAQKAREEEERAKREEL 201
+ + E L R+ + +K+L E LERQ++ A L+ R + + A+ E
Sbjct: 88 VEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETT 147
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
E+ K Q + E+ V + + ++ R E +++ ++KEE++
Sbjct: 148 EK-----EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEE 194
Score = 32.3 bits (72), Expect = 0.46
Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 15/114 (13%)
Query: 151 DEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENN- 209
D+ ER R + KR + E + QR + + ARE RA++E L + EE +
Sbjct: 2 DDFERR--RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
Query: 210 ------------RKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
+ + +AK ++ + ER+ +ER++++ +E
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQE 113
Score = 30.0 bits (66), Expect = 2.3
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 197 KREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
+R EL R E R AE A + +E+ E R + QER RQ++EE+ +
Sbjct: 6 RRRELRRQKREEMRLEAERIAYQRNDD----DEEEAARERRRRARQERLRQKQEEESL 59
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 85.9 bits (211), Expect = 3e-17
Identities = 68/261 (26%), Positives = 132/261 (50%), Gaps = 27/261 (10%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKS-RESKRNRRRESRSRSRSTNTAVSRRERDRER 74
K + KK + +++ER+R+R K RE + R + + + E++ ++
Sbjct: 431 KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 490
Query: 75 ASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFE---------RQRKIRQQEIEEKL 125
P + ++ + K +EK +EE+ + + E RQ K+R+QE +++
Sbjct: 491 QRLPEQKEKLWEQ--EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE--DQM 546
Query: 126 IEEETARRVEELVAKRVEEELEKRKDEIER-----EVLRRVEEAKRIMEKQLLEELE--R 178
E+E R +E EE +EK+ E E+ E R EE R EK++ EE E R
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 179 QRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM 238
+++ ++ Q+ + +E+ K E E ++E K+ E + K+ E++ ++ E+QR + E++
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR-LPEQKE 665
Query: 239 KL-----EQERQRQQKEEQKI 254
KL QE+++ Q++E+KI
Sbjct: 666 KLWEHEKMQEQEKMQEQEEKI 686
Score = 81.6 bits (200), Expect = 7e-16
Identities = 70/271 (25%), Positives = 134/271 (49%), Gaps = 25/271 (9%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKE-RVRKRSKSRESKRNRRRESRSRSRSTNT 63
R R + K K +K R R R++E ++R++ + + R RE R
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335
Query: 64 AVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEE----EKKAEFERQRKIRQQ 119
+ ++ RE+ ++ + K +EK R+EE ++K E+++K+R Q
Sbjct: 336 ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 395
Query: 120 EI-----EEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLR----RVEEAKRIME- 169
E +E+L E+E R +E + ++VE+ E++K + + + R +++E +RI E
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 170 -KQLLEELERQRQAELAAQKAREEE-ERAKREELERILEENNRKIAEAQAKLAEEQLRIV 227
K++ EE E R+ E QK E E+ ++E ++ L E K+ E Q K+ E++ +I
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE-QEKMQEQEEKIW 514
Query: 228 EEQRKIHE-------ERMKLEQERQRQQKEE 251
E++ KI + E+ QE+ R+Q+++
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Score = 81.6 bits (200), Expect = 7e-16
Identities = 65/263 (24%), Positives = 127/263 (48%), Gaps = 23/263 (8%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
M R R + K + + + R +D+ K + RE ++ + + R
Sbjct: 371 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK 430
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAE-----FERQRK 115
++ RD+E +RI R K+ +E+ RE+EEK + +E++ K
Sbjct: 431 KMQEQEKKTRDQEEKMQEEERI----REREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 116 IRQQ----EIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQ 171
QQ E +EKL E+E + EE + ++ EE++ +++ +E +E R E Q
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ-EEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Query: 172 LLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQR 231
+ E+ E+ R E QK ++EER +E+ +E +K + + K+ EE+ R+ E ++
Sbjct: 546 MWEQEEKMRDQE---QKMWDQEER-----MEKKTQEQEKKTWDQEEKMREEE-RMREREK 596
Query: 232 KIHEERMKLEQERQRQQKEEQKI 254
K+ EE + ++ ++ Q++E+K+
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKM 619
Score = 80.5 bits (197), Expect = 1e-15
Identities = 64/270 (23%), Positives = 141/270 (52%), Gaps = 34/270 (12%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKR-SKSRESKRNRRRESRSRSRSTNTAVSRRE 69
R + + + +++ R R++E++ ++ K RE K+ + +E ++R + R
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERI 452
Query: 70 RDRERASSPPDRIDIFGRTVSKRSSLDEKQKREE---EEKKAEFERQRKIRQ-------- 118
R+RE+ + + R ++ QK+EE E+++ E+++QR Q
Sbjct: 453 REREKKMREEEE--------TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504
Query: 119 --QEIEEKLIE-EETARRVEELVAKRV----EEELEKRKDEI-EREVLRRVEEAKRIMEK 170
QE EEK+ E EE R EE+ + +E++ +++D++ E+E R +E K ++
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 564
Query: 171 QLLEE--LERQRQAELAAQKAREEEERAKRE----ELERILEENNRKIAEAQAKLAEEQL 224
+ +E+ E++++ +K REEE +RE E E ++ E K+ E + K+ E++
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 624
Query: 225 RIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
++ E++ K+ E+ K+ ++ ++ ++E+K+
Sbjct: 625 KMWEQEEKMQEQEEKMWEQEEKMWEQEEKM 654
Score = 77.0 bits (188), Expect = 2e-14
Identities = 64/259 (24%), Positives = 130/259 (50%), Gaps = 23/259 (8%)
Query: 4 SRSRSSSRSKHTKSSKHNKKRSRS-----RSRSRDKERVRKRSKSRESKRNRRRESRSRS 58
+ S S + K K +R++ ++ + +E R+ + RE ++ R++
Sbjct: 237 AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMW 296
Query: 59 RSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFE--RQRKI 116
R + ER RE+ ++ + R KR EK+ RE+E++ E + R+++
Sbjct: 297 R-------QEERLREQEGKMREQEEKMWRQ-EKRLREQEKELREQEKELREQKELREQEE 348
Query: 117 RQQEIEEKLIE-EETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEE 175
+ QE EEK+ E EE R EE + ++ E E+ K +R E+ R E+++ E+
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ------MREQEQKMRDQEERMWEQ 402
Query: 176 LERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHE 235
ER R+ E ++ + E+ ++ E+ ++E +K + + K+ EE+ RI E ++K+ E
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE-RIREREKKMRE 461
Query: 236 ERMKLEQERQRQQKEEQKI 254
E + ++ ++ QK+E+ +
Sbjct: 462 EEETMREQEEKMQKQEENM 480
Score = 77.0 bits (188), Expect = 2e-14
Identities = 67/256 (26%), Positives = 129/256 (50%), Gaps = 32/256 (12%)
Query: 22 KKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDR 81
++R +++ ++K+ + K RE +R R RE + R + E+ +E+ ++
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR-EQEEKMQEQEEKMQEQ 622
Query: 82 IDIFGRTVSKRSSLDEKQKREEE----EKKAEFERQRKIRQQEI---EEKLIEEETARRV 134
+ K +EK +EE +++ +E+QR Q+E EK+ E+E +
Sbjct: 623 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 135 EELVAKRVEEELEKRKDEIEREVL----RRVEEAKRIMEKQLLEELERQRQAELAAQKAR 190
EE + + +E++EK+ E E++ R EE+ R EK++ EE E R+ E +K +
Sbjct: 683 EEKIWE--QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE---EKMQ 737
Query: 191 EEEERAKREELERILEENNRKIAEAQAKLAEEQL-----------RIVEEQRKI--HEER 237
E+EE+ + +E E + E K+ E + K+ E+Q ++EQ KI EE+
Sbjct: 738 EQEEKMQEQEEE--MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK 795
Query: 238 MKLEQERQRQQKEEQK 253
M+ ++E+ R Q+E+ +
Sbjct: 796 MRDQEEKMRGQEEKMR 811
Score = 75.9 bits (185), Expect = 4e-14
Identities = 57/250 (22%), Positives = 129/250 (51%), Gaps = 19/250 (7%)
Query: 13 KHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDR 72
+ K + + + RD+E+ + R K+ + +E ++ + R R+R
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 73 ERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI-----EEKLIE 127
E+ + + + + E++++ +E+++ +E++ K+++QE EEK+ E
Sbjct: 595 EKKMREEEEM-----MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
Query: 128 EETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQ 187
+E ++ + ++ E+ E K + E+E ++ EE +I E++ +E+ ++++ + Q
Sbjct: 650 QEEKMWEQQRLPEQKEKLWEHEKMQ-EQEKMQEQEE--KIWEQEKMEKKTQEQEKKTWDQ 706
Query: 188 -KAREEEERAKRE----ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL-E 241
K REEE +RE E E ++ E K+ E + K+ E++ + E++ K+ E+ K+ E
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766
Query: 242 QERQRQQKEE 251
Q+R +QKE+
Sbjct: 767 QQRLPEQKEK 776
Score = 74.7 bits (182), Expect = 8e-14
Identities = 72/251 (28%), Positives = 126/251 (50%), Gaps = 32/251 (12%)
Query: 15 TKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRE-RDRE 73
T + + R R ++K ++RK+ + + R RE + R + R+E R RE
Sbjct: 267 TNTLQEEMWRQEEELREQEK-KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLRE 325
Query: 74 RASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIE-EETAR 132
+ ++ ++ ++K+ RE+EE+ E E + E EEK+ E EE
Sbjct: 326 QEKELREQ---------EKELREQKELREQEEQMQEQEE----KMWEQEEKMREQEEKMW 372
Query: 133 RVEELV---AKRVEEELEKRKDEIER-----EVLRRVEEAKRIMEKQLLEELERQRQAEL 184
R EE + K++ E+ +K +D+ ER E LR EE R EK + E++E+ R+
Sbjct: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK-MWEQVEKMRE--- 428
Query: 185 AAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM--KLEQ 242
+K +E+E+ R++ E++ EE + E + + EE +R EE+ + EE M + E+
Sbjct: 429 --EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 243 ERQRQQKEEQK 253
E Q+Q+ EQK
Sbjct: 487 EWQQQRLPEQK 497
Score = 73.9 bits (180), Expect = 1e-13
Identities = 60/256 (23%), Positives = 119/256 (46%), Gaps = 25/256 (9%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER----- 70
K+ + KK + R++ER+R+R K + RE + + + +E
Sbjct: 570 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 71 -------------DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIR 117
E+ +++ R ++ L E +K +E+EK E++ KI
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ--EQEEKIW 687
Query: 118 QQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELE 177
+QE EK +E+ + ++ + E E+ K E E + R +E K M++Q EE
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK--MQEQ--EEKM 743
Query: 178 RQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
++++ E+ Q+ + E+ K E +R L E K+ E + +E++ EE+ + EE+
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQR-LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Query: 238 MKLEQERQRQQKEEQK 253
M+ ++E+ R Q+E+ +
Sbjct: 803 MRGQEEKMRGQEEKMR 818
Score = 66.6 bits (161), Expect = 2e-11
Identities = 54/268 (20%), Positives = 138/268 (51%), Gaps = 25/268 (9%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRR--------ESRS 56
R+ S+ ++H K+ ++ ++ ++ R + E R + E K+ ES
Sbjct: 183 RALSAVSTRHKKADRYIEELTKERD-ALSLELYRNTITNEELKKKNAELQEKLPLAESEK 241
Query: 57 RSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSS-LDEKQKREEEEKKAEFERQRK 115
N +R+ +R + P + + + ++ L E++K+ ++++ + ++ +
Sbjct: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
Query: 116 IRQQE-----IEEKLIEEETARRVEELVAK------RVEEELEKRKDEIEREVLRRVEEA 164
+R+QE EEK+ +E R +E + R ++EL +++++++ + + E+
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
Query: 165 KRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQL 224
+++ E++ E++ RQ + +K E+E+ R++ ER+ E++ R + E + ++ E++
Sbjct: 362 EKMREQE--EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER-LREKEERMREQE- 417
Query: 225 RIVEEQRKIHEERMKLEQERQRQQKEEQ 252
++ E+ K+ EE+ EQE++ + +EE+
Sbjct: 418 KMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Score = 60.5 bits (145), Expect = 2e-09
Identities = 54/263 (20%), Positives = 124/263 (47%), Gaps = 18/263 (6%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R R R K + + + + + ++++ + K E + + +
Sbjct: 586 REEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEE 645
Query: 63 TAVSRRERDRERASSPPDRIDIFG--------RTVSKRSSLDEKQKREEEEKKAEFER-- 112
+ E+ E+ P + ++ + + + E++K E++ ++ E +
Sbjct: 646 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD 705
Query: 113 QRKIRQQEI----EEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM 168
Q K+R++E E+K+ EEE R +E + EE+++++++E+ + + E+ +++
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765
Query: 169 EKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVE 228
E+Q L E Q++ +K +E+E+ ++EE R EE R E + + EE++R E
Sbjct: 766 EQQRLPE---QKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG-QEEKMRGQEEKMRGQE 821
Query: 229 EQRKIHEERMKLEQERQRQQKEE 251
E+ EE+M ++E+ Q+E+
Sbjct: 822 EKMWGQEEKMWGQEEKMWGQEEK 844
Score = 60.5 bits (145), Expect = 2e-09
Identities = 53/236 (22%), Positives = 120/236 (50%), Gaps = 18/236 (7%)
Query: 22 KKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERD--RERASSPP 79
K++ + +++E+++++ + + ++++ + + T RE + RER
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723
Query: 80 DRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVA 139
+ ++ K +EK + +EEE +E++ K+ +Q EEK+ E++ R+ E
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEM---WEQEEKMWEQ--EEKMWEQQ---RLPEQKE 775
Query: 140 KRVEEELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAK 197
K E E + +++I + E +R EE R E+++ + E+ R E +K +EE+
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE---EKMWGQEEKMW 832
Query: 198 REELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQK 253
+E + +E Q + EE+++ EE+ + EE+M+ ++E+ R+Q+E+ +
Sbjct: 833 GQEEKMWGQEEK---MWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
Score = 57.0 bits (136), Expect = 2e-08
Identities = 57/254 (22%), Positives = 115/254 (45%), Gaps = 39/254 (15%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
M K + K KK ++ D+E++R+ RE ++ R E
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
+ E+ +E+ + ++++K E+E+K +E+QR Q+E
Sbjct: 733 EEKMQEQEEKMQEQ----------------EEEMWEQEEKMWEQEEKM-WEQQRLPEQKE 775
Query: 121 I---EEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELE 177
EK+ E+E ++ E+ EK +D+ E+ +R EE R E+++ + E
Sbjct: 776 KLWEHEKMQEQE-----------KIWEQEEKMRDQEEK--MRGQEEKMRGQEEKMRGQEE 822
Query: 178 RQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
+ E +K +EE+ +E E++ + + + Q + EE++R EE+ + EE+
Sbjct: 823 KMWGQE---EKMWGQEEKMWGQE-EKMWGQEEKMEEKMQGQ--EEKMREQEEKMRGQEEK 876
Query: 238 MKLEQERQRQQKEE 251
M+ ++E+ R Q+E+
Sbjct: 877 MREQEEKMRGQEEK 890
Score = 55.1 bits (131), Expect = 7e-08
Identities = 52/176 (29%), Positives = 95/176 (53%), Gaps = 16/176 (9%)
Query: 87 RTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI-EEETARRVEELVAKRVEEE 145
R +S S+ +K R EE ++R E+ I EE ++ EL K E
Sbjct: 183 RALSAVSTRHKKADRYIEE----LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAE 238
Query: 146 LEKRKDEIE-REVLRRVEEAK----RIMEKQLLEELERQRQAELAAQ--KAREEEERAKR 198
EK + ++ +E+ R++E AK ++ L EE+ RQ + EL Q K R++EE+ R
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE-ELREQEKKIRKQEEKMWR 297
Query: 199 EELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKL-EQERQRQQKEEQK 253
+E ER+ E+ K+ E + K+ ++ R+ E+++++ E+ +L EQ+ R+Q+E+ +
Sbjct: 298 QE-ERLREQEG-KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQ 351
Score = 42.4 bits (98), Expect = 4e-04
Identities = 28/124 (22%), Positives = 62/124 (50%), Gaps = 8/124 (6%)
Query: 139 AKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKR 198
A R EEL K +D + E+ R + + L++ + Q +L ++ + E +
Sbjct: 195 ADRYIEELTKERDALSLELYRNT------ITNEELKKKNAELQEKLPLAESEKSEIQLNV 248
Query: 199 EELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGK 258
+EL+R LE + + Q +E++ EE+ + E+ K+ ++ ++ ++E+++ +
Sbjct: 249 KELKRKLERAKFLLPQVQTNTLQEEMWRQEEE--LREQEKKIRKQEEKMWRQEERLREQE 306
Query: 259 GKSR 262
GK R
Sbjct: 307 GKMR 310
Score = 30.8 bits (68), Expect = 1.3
Identities = 26/138 (18%), Positives = 60/138 (43%), Gaps = 2/138 (1%)
Query: 16 KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERA 75
K + +K + KE++ + K +E ++ +E + R + + +
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Query: 76 SSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVE 135
++G+ K +EK +EE+ + E+ + + Q EEK+ E+E R +
Sbjct: 816 KMRGQEEKMWGQE-EKMWGQEEKMWGQEEKMWGQEEKMEE-KMQGQEEKMREQEEKMRGQ 873
Query: 136 ELVAKRVEEELEKRKDEI 153
E + EE++ ++++I
Sbjct: 874 EEKMREQEEKMRGQEEKI 891
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 84.7 bits (208), Expect = 8e-17
Identities = 53/226 (23%), Positives = 124/226 (54%), Gaps = 11/226 (4%)
Query: 30 RSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTV 89
+ ++E++R++ + R+ + + RE R + E+ RE+ ++ ++
Sbjct: 352 KMHEQEKIREQEEKRQEEE-KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQE 410
Query: 90 SKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKR 149
K +EK +EEE + E++ K+R+QE EK+ E+E R +E + EE ++++
Sbjct: 411 EKMGEQEEKMWEQEEEMQ---EQEEKMRRQE--EKIREQEKKIREQEEKIREQEEMMQEQ 465
Query: 150 KDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENN 209
++++ + + E+ ++ E+ EE R+++ ++ Q+ + E+ K E E +++E
Sbjct: 466 EEKMGEQEGKMCEQEAKMQEQ---EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 522
Query: 210 RKIAEAQAKLAEEQLRIVEEQRKI--HEERMKLEQERQRQQKEEQK 253
K+ E + K+ E++ ++ E++ K+ EE+M+ ++ R RQQ+E+ +
Sbjct: 523 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 83.2 bits (204), Expect = 2e-16
Identities = 63/274 (22%), Positives = 131/274 (47%), Gaps = 30/274 (10%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
M R + R + + + + + R +++ K K R + E + R
Sbjct: 290 MWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE-MMWEKEEKIRE 348
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
+ +E+ RE+ + I R KR + K R+EE+ + E++ KIR+QE
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKI--REQEKRQEQEAKMWRQEEKIR---EQEEKIREQE 403
Query: 121 I------------EEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIM 168
EEK+ E+E + +E +R EE++ +++ +I RE ++ E + +M
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI-REQEEKIREQEEMM 462
Query: 169 EKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVE 228
++Q EE +++ ++ Q+A+ +E+ K E + E +KI E + K+ E++ + E
Sbjct: 463 QEQ--EEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520
Query: 229 EQRKI---------HEERMKLEQERQRQQKEEQK 253
++ K+ EE+M+ ++E+ R+Q+E+ +
Sbjct: 521 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554
Score = 82.8 bits (203), Expect = 3e-16
Identities = 52/237 (21%), Positives = 129/237 (54%), Gaps = 17/237 (7%)
Query: 32 RDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRE----RDRERASSPPDRIDIFGR 87
R +E++++R + + + + RE + R + +E R E ++I
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351
Query: 88 TVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI---EEKLIEEETARRVEELVAKRVEE 144
+ ++ + E++++ +EE+K + +R+ ++ ++ EEK+ E+E R +E + + EE
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411
Query: 145 ELEKRKDEI--EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKRE--- 199
++ ++++++ + E ++ EE R E+++ E+ ++ R+ E +K RE+EE + +
Sbjct: 412 KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQE---EKIREQEEMMQEQEEK 468
Query: 200 --ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E E + E K+ E + K+ ++ +I E+++KI E+ K+ ++ + Q++E+K+
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 525
Score = 77.4 bits (189), Expect = 1e-14
Identities = 56/222 (25%), Positives = 116/222 (52%), Gaps = 20/222 (9%)
Query: 48 RNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREE---- 103
R +++ R R E+ +E+ ++ + R +EK +R+E
Sbjct: 281 RLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 340
Query: 104 --EEKKAEFE----RQRKIRQQE---IEEKLIEEETARRVEELVAKRVEEELEKRKDEI- 153
EEK E E Q KIR+QE EE+ I E+ R+ +E R EE++ +++++I
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Query: 154 -EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKI 212
+ E+++ EE E+++ E+ E ++ E +K R +EE+ + E E+ + E KI
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE---EKMRRQEEKIR--EQEKKIREQEEKI 455
Query: 213 AEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E + + E++ ++ E++ K+ E+ K++++ ++ +++E+KI
Sbjct: 456 REQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKI 497
Score = 76.3 bits (186), Expect = 3e-14
Identities = 53/230 (23%), Positives = 118/230 (51%), Gaps = 14/230 (6%)
Query: 13 KHTKSSKHNKKRSRSRSRSR-DKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERD 71
+ + H +++ R + R ++E++R++ K +E + R+ + E
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 72 RERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI----EEKLIE 127
+E+ ++ + + +EK +R+EE+ + E+++KIR+QE +E++++
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR---EQEKKIREQEEKIREQEEMMQ 463
Query: 128 EETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQ 187
E+ ++ E K E+E + ++ E E +RR EE R EK++ E+ E+ R+ E Q
Sbjct: 464 EQ-EEKMGEQEGKMCEQEAKMQEQE---EKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 519
Query: 188 KAREE--EERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHE 235
+ E+ E+ K E E ++E K+ + K+ E+++R+ +++ K+ E
Sbjct: 520 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 71.6 bits (174), Expect = 7e-13
Identities = 59/233 (25%), Positives = 123/233 (52%), Gaps = 17/233 (7%)
Query: 28 RSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGR 87
R+ D+E K +K +E + + ES N +R+ +R + P ++
Sbjct: 199 RNTITDEELKEKNAKLQE--KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 256
Query: 88 TVSKR-SSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEEL 146
+ K S+ K + + EE E ++ QQ+ E+ +EE + EE + ++ EE++
Sbjct: 257 HLGKELQSVSAKLQAQVEEN----ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ-EEKI 311
Query: 147 EKRKDEIER--EVLRRVEEAKRIMEKQLLEELERQRQAELAA---QKAREEEERAKREEL 201
++++++ R E++ EE R E+ + E+ E+ R+ E +K RE+EE KR+E
Sbjct: 312 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEE 369
Query: 202 ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E+I E+ R+ E +AK+ ++ +I E++ KI E+ ++++ ++ ++E+K+
Sbjct: 370 EKIREQEKRQ--EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Score = 48.1 bits (113), Expect = 8e-06
Identities = 37/175 (21%), Positives = 89/175 (50%), Gaps = 22/175 (12%)
Query: 99 QKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIE---R 155
QK++ + E ++R E+ I +E + + ++++ +E K EI+ +
Sbjct: 175 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL-VESEKSEIQLNVK 233
Query: 156 EVLRRVEEAKRIMEKQLLE---------------ELERQ-RQAELAAQKAREEEERAKRE 199
E+ R++E AK ++ +Q L+ +L+ Q + EL + +++EE+ R+
Sbjct: 234 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293
Query: 200 ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
E + ++E KI E + K+ E++ ++ ++ + E+ K+ ++ + ++E+KI
Sbjct: 294 EEK--IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 346
Score = 33.5 bits (75), Expect = 0.20
Identities = 24/136 (17%), Positives = 57/136 (41%), Gaps = 5/136 (3%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
M R + + K + + + + ++++ + K E + + + R
Sbjct: 434 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQ 493
Query: 61 TNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
+ ++ RE+ ++ ++ K +EK +EE+ + E++ K+R+Q
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ---EQEEKMRRQ- 549
Query: 121 IEEKLIEEETARRVEE 136
EEK+ E+E R +E
Sbjct: 550 -EEKMREQEVRLRQQE 564
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 84.7 bits (208), Expect = 8e-17
Identities = 79/287 (27%), Positives = 137/287 (47%), Gaps = 29/287 (10%)
Query: 2 GRSRS--RSSSRSKHTKSSK----HNKKRSRSRSRSRDKERVRKRSKSRESKRNR---RR 52
GRSRS RS SRS S+ +K RSRS +RSR +++ R+RSKS KR++ RR
Sbjct: 306 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR 365
Query: 53 ESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER 112
+SRSRS S + RE+ +E+ +R+ R EK++ E+E++ E ER
Sbjct: 366 KSRSRSHSRDKRKDTREKIKEK-----ERVKEKDR---------EKEREREKEREKEKER 411
Query: 113 QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKD-EIEREVLRRVEEAKRIMEKQ 171
+ + + EK E++ + E K E++ +K K+ E ++E R + +K I EK+
Sbjct: 412 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471
Query: 172 LLEELERQRQAELAAQKAREEEERAKREELERILEENNR--KIAEAQAKLAEEQLRIVEE 229
++ R A + R +R R + R K + ++ + ++
Sbjct: 472 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 531
Query: 230 QRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKL---SFSLKTQD 273
+K +ER + + R+R++ + + KL S SLK ++
Sbjct: 532 DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE 578
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/243 (23%), Positives = 105/243 (43%), Gaps = 19/243 (7%)
Query: 22 KKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDR 81
K R RSR R + RS S+ R +R +S+ RSRS N + S R++DR R+ SP
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRS-RQKDRRRSKSP--- 354
Query: 82 IDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKR 141
+K+ + E +K+ + ++++ EK+ E+E + + +
Sbjct: 355 --------------HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERE 400
Query: 142 VEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE-EEERAKREE 200
E+E EK K+ + + + E R +K+ E ER+++ E K +E E+++ K E
Sbjct: 401 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 460
Query: 201 LERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGK 260
+R E + ++ + +++ R ER + + K I K
Sbjct: 461 KDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSS 520
Query: 261 SRP 263
P
Sbjct: 521 RSP 523
Score = 75.1 bits (183), Expect = 6e-14
Identities = 77/295 (26%), Positives = 128/295 (43%), Gaps = 46/295 (15%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNR---RRESRSRSR 59
RS+SRSSS+S + +K RSRS +RSR +++ R+RSKS KR++ RR+SRSRS
Sbjct: 313 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSH 372
Query: 60 STNTAVS------------------RRERDRERASSPP-----DRIDIFGRTVSKRSSLD 96
S + RER++ER DR + K D
Sbjct: 373 SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432
Query: 97 EKQKRE-----EEEKKAEFERQR-----KIRQQEIEEKLIEEETARRVEEL--VAKRVEE 144
+++RE + +K+ E E+ + K R +EI+EK +++ +R ++R
Sbjct: 433 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 492
Query: 145 ELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEE-----ERAKRE 199
+R+ R R +K I K R R + K RE+E ER +RE
Sbjct: 493 SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK---DKKREKERDHISERRERE 549
Query: 200 ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
+ + +N + + + + L+ E ++ K ++ + EE KI
Sbjct: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 604
Score = 53.1 bits (126), Expect = 2e-07
Identities = 39/142 (27%), Positives = 69/142 (48%), Gaps = 4/142 (2%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRS-RDKERVRKRSKSRESKRNRRRESRSRSRSTNT 63
RS ++SR + S + ++RSRS SRS R + ++++S S R+R ++ + R + +
Sbjct: 482 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 541
Query: 64 AVSRRERDRERA--SSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI 121
RRER+R + S DR D + +SL EK+ +E + E K +
Sbjct: 542 ISERRERERSTSMRKSSNDR-DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
Query: 122 EEKLIEEETARRVEELVAKRVE 143
E K+ + EE ++ + E
Sbjct: 601 ENKIQHNGNCQLNEENLSTKTE 622
Score = 28.1 bits (61), Expect = 8.6
Identities = 23/108 (21%), Positives = 44/108 (40%), Gaps = 3/108 (2%)
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
+++ E + K+L E ++R R+A+ A E E E + R + +
Sbjct: 260 IVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS 319
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
+K + R + R R + Q+ +R+ K K + KSR +
Sbjct: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK---KRSKSRER 364
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 84.7 bits (208), Expect = 8e-17
Identities = 79/287 (27%), Positives = 137/287 (47%), Gaps = 29/287 (10%)
Query: 2 GRSRS--RSSSRSKHTKSSK----HNKKRSRSRSRSRDKERVRKRSKSRESKRNR---RR 52
GRSRS RS SRS S+ +K RSRS +RSR +++ R+RSKS KR++ RR
Sbjct: 190 GRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERR 249
Query: 53 ESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFER 112
+SRSRS S + RE+ +E+ +R+ R EK++ E+E++ E ER
Sbjct: 250 KSRSRSHSRDKRKDTREKIKEK-----ERVKEKDR---------EKEREREKEREKEKER 295
Query: 113 QRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKD-EIEREVLRRVEEAKRIMEKQ 171
+ + + EK E++ + E K E++ +K K+ E ++E R + +K I EK+
Sbjct: 296 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 355
Query: 172 LLEELERQRQAELAAQKAREEEERAKREELERILEENNR--KIAEAQAKLAEEQLRIVEE 229
++ R A + R +R R + R K + ++ + ++
Sbjct: 356 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 415
Query: 230 QRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKL---SFSLKTQD 273
+K +ER + + R+R++ + + KL S SLK ++
Sbjct: 416 DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKE 462
Score = 80.1 bits (196), Expect = 2e-15
Identities = 57/243 (23%), Positives = 105/243 (43%), Gaps = 19/243 (7%)
Query: 22 KKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDR 81
K R RSR R + RS S+ R +R +S+ RSRS N + S R++DR R+ SP
Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRS-RQKDRRRSKSP--- 238
Query: 82 IDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKR 141
+K+ + E +K+ + ++++ EK+ E+E + + +
Sbjct: 239 --------------HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERE 284
Query: 142 VEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKARE-EEERAKREE 200
E+E EK K+ + + + E R +K+ E ER+++ E K +E E+++ K E
Sbjct: 285 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 344
Query: 201 LERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGK 260
+R E + ++ + +++ R ER + + K I K
Sbjct: 345 KDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSS 404
Query: 261 SRP 263
P
Sbjct: 405 RSP 407
Score = 75.1 bits (183), Expect = 6e-14
Identities = 77/295 (26%), Positives = 128/295 (43%), Gaps = 46/295 (15%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNR---RRESRSRSR 59
RS+SRSSS+S + +K RSRS +RSR +++ R+RSKS KR++ RR+SRSRS
Sbjct: 197 RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSH 256
Query: 60 STNTAVS------------------RRERDRERASSPP-----DRIDIFGRTVSKRSSLD 96
S + RER++ER DR + K D
Sbjct: 257 SRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 316
Query: 97 EKQKRE-----EEEKKAEFERQR-----KIRQQEIEEKLIEEETARRVEEL--VAKRVEE 144
+++RE + +K+ E E+ + K R +EI+EK +++ +R ++R
Sbjct: 317 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 376
Query: 145 ELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEE-----ERAKRE 199
+R+ R R +K I K R R + K RE+E ER +RE
Sbjct: 377 SSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK---DKKREKERDHISERRERE 433
Query: 200 ELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKI 254
+ + +N + + + + L+ E ++ K ++ + EE KI
Sbjct: 434 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKI 488
Score = 53.1 bits (126), Expect = 2e-07
Identities = 39/142 (27%), Positives = 69/142 (48%), Gaps = 4/142 (2%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRS-RDKERVRKRSKSRESKRNRRRESRSRSRSTNT 63
RS ++SR + S + ++RSRS SRS R + ++++S S R+R ++ + R + +
Sbjct: 366 RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDH 425
Query: 64 AVSRRERDRERA--SSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI 121
RRER+R + S DR D + +SL EK+ +E + E K +
Sbjct: 426 ISERRERERSTSMRKSSNDR-DGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 484
Query: 122 EEKLIEEETARRVEELVAKRVE 143
E K+ + EE ++ + E
Sbjct: 485 ENKIQHNGNCQLNEENLSTKTE 506
Score = 28.1 bits (61), Expect = 8.6
Identities = 23/108 (21%), Positives = 44/108 (40%), Gaps = 3/108 (2%)
Query: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
+++ E + K+L E ++R R+A+ A E E E + R + +
Sbjct: 144 IVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS 203
Query: 217 AKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPK 264
+K + R + R R + Q+ +R+ K K + KSR +
Sbjct: 204 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHK---KRSKSRER 248
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 84.3 bits (207), Expect = 1e-16
Identities = 69/282 (24%), Positives = 138/282 (48%), Gaps = 42/282 (14%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R R + K + KK R + ++E++R+ K +E + R+E + +
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW- 492
Query: 65 VSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFE-----RQRKIRQQ 119
R +E+ ++I R ++ E++ RE+EEK E E ++ KIR+Q
Sbjct: 493 -----RQKEKMHEQEEKI----RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 543
Query: 120 EI----EEKLIE-----EETARRVEELVAKRVEEELEKRKDEIER--EVLRRVEEAKRIM 168
E EEK+ E EE R+ +E R EE++ ++++++ R E +R EE ++
Sbjct: 544 EEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603
Query: 169 EKQLLEELERQRQAELAAQKAREE--EERAKREELERILEENNRKIAEAQAKLAEEQLR- 225
E+++ ++ E+ R+ E Q+ E+ E+ K E E + +E K+ E + K+ E++ +
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 663
Query: 226 -------------IVEEQRKIHEERMKLEQERQRQQKEEQKI 254
I E+++KI E+ K+ ++ + Q++E+K+
Sbjct: 664 QEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 705
Score = 80.5 bits (197), Expect = 1e-15
Identities = 60/257 (23%), Positives = 126/257 (49%), Gaps = 15/257 (5%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRER 70
R + K K R + +E++R++ + K + RE + + E+
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412
Query: 71 --DRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI---EEKL 125
+ E+ R + + + + E++++ E++K + ++ KI +QE EEK
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472
Query: 126 IEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAE-- 183
E+E R EE + ++ E +K K + E +R+ EE E+++ E+ E+ R+ E
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Query: 184 --LAAQKAREEEERAKREEL----ERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
+K RE+EE + EE E+I EE R+ E + K+ ++ +I E++ K+ +
Sbjct: 533 MWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQ--EQEDKMWRQEEKIREQEEKVWRQE 590
Query: 238 MKLEQERQRQQKEEQKI 254
K+ ++ +++Q++E+K+
Sbjct: 591 EKIREQEEKRQEQEEKM 607
Score = 80.5 bits (197), Expect = 1e-15
Identities = 61/265 (23%), Positives = 131/265 (49%), Gaps = 25/265 (9%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERV---------RKRSKSRESKRNRRRESR 55
R + + K K +K R + R++E R+ K RE + R E +
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 56 SRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFE---- 111
+ +R+ ++ ++I R ++ E++ RE+EEK+ E E
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKI----REQEEKVWRQEEKIREQEEKRQEQEEKMW 608
Query: 112 -RQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEK 170
++ KIR+QE EK+ E+E R +E + EE +++++++ + + E+ +++ E+
Sbjct: 609 KQEEKIREQE--EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666
Query: 171 QLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQ 230
EE +++ ++ Q+ + E+ K E E +++E K+ E + K+ E++ ++ E++
Sbjct: 667 ---EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 723
Query: 231 RKI--HEERMKLEQERQRQQKEEQK 253
K+ EE+M ++ R RQQ+E+ +
Sbjct: 724 EKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 79.3 bits (194), Expect = 3e-15
Identities = 69/257 (26%), Positives = 134/257 (52%), Gaps = 38/257 (14%)
Query: 30 RSRDKERVRKRSKSR-ESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRT 88
+ ++E++R++ + R E ++ R +E R + + R++E ++ +
Sbjct: 399 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK-----KM 453
Query: 89 VSKRSSLDEKQKREEEEKKAEFE----RQRKIRQQEI----EEKLIE-EETARRVEELV- 138
+ + E++K EEEK+ E E ++ KI +QE +EK+ E EE R+ EE V
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW 513
Query: 139 --AKRVEEELEKRKDEIER-----EVLRRVEEAKRIMEK-----QLLEELERQRQAE--- 183
+++ E+ EK +++ E+ E +R EE R EK ++ EE +RQ Q +
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 184 LAAQKAREEEERAKREELERILE------ENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237
+K RE+EE+ R+E E+I E E K+ + + K+ E++ +I E++ KI E+
Sbjct: 574 RQEEKIREQEEKVWRQE-EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE 632
Query: 238 MKLEQERQRQQKEEQKI 254
K+ ++ + Q++E+K+
Sbjct: 633 EKIREQEEMTQEQEEKM 649
Score = 76.6 bits (187), Expect = 2e-14
Identities = 54/159 (33%), Positives = 98/159 (61%), Gaps = 18/159 (11%)
Query: 96 DEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEI-- 153
+EK +R+EE +E++ K+R+QE E +EE RR EE++ ++ EE +R++E+
Sbjct: 334 EEKMRRQEEMM---WEKEEKMRRQE-EMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMW 387
Query: 154 -EREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKI 212
+ E +R +EE ++ E++ + E E +RQ E +K RE+E KR+E E + KI
Sbjct: 388 EKEEKIRELEE--KMHEQEKIREQEEKRQEE---EKIREQE---KRQEQEAKMWRQEEKI 439
Query: 213 AEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEE 251
E + K+ E++ ++ ++ KIHE+ K+ +E +RQ++EE
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQE-KIREEEKRQEQEE 477
Score = 75.9 bits (185), Expect = 4e-14
Identities = 58/245 (23%), Positives = 121/245 (49%), Gaps = 22/245 (8%)
Query: 24 RSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRID 83
R + + +++ + K RE + R + R + E+ R + ++ +
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 84 IFGRTVSKRSSLDEKQKREEE------EKKAEFER----QRKIRQQEI---EEKLIEEET 130
R +EK +R+EE EK E E Q KIR+QE EE+ I E+
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
Query: 131 ARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLL-EELERQRQAELAAQKA 189
R+ +E R EE++ +++++I + + + ++I E++ + EE +RQ Q E+
Sbjct: 424 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM----W 479
Query: 190 REEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQK 249
R+EE+ ++EE+ R K+ E + K+ +++ ++ ++ KI E+ K+ ++ ++ +
Sbjct: 480 RQEEKIHEQEEIWR----QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR 535
Query: 250 EEQKI 254
+E+KI
Sbjct: 536 QEEKI 540
Score = 74.3 bits (181), Expect = 1e-13
Identities = 63/230 (27%), Positives = 121/230 (52%), Gaps = 17/230 (7%)
Query: 34 KERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRE-RDRERASSPPDRIDIFGRTVSKR 92
+E++ ++ K RE + R+ E + R + + R E+ ++I R K+
Sbjct: 397 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI----REQEKK 452
Query: 93 SSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDE 152
E++ E+E+ + E +RQ + EEK+ E+E R +E + ++ EE++ K++++
Sbjct: 453 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQ-EEKIRKQEEK 511
Query: 153 IER--EVLRRVEEAKRIMEKQLLEELERQRQAE---LAAQKAREEE---ERAKREELERI 204
+ R E +R EE R E+++ + E+ R+ E +K E+E E KR+E E
Sbjct: 512 VWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDK 571
Query: 205 LEENNRKIAEAQAKL--AEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQ 252
+ KI E + K+ EE++R EE+R+ EE+M +QE + +++EE+
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM-WKQEEKIREQEEK 620
Score = 71.2 bits (173), Expect = 9e-13
Identities = 57/251 (22%), Positives = 117/251 (46%), Gaps = 18/251 (7%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKS----RESKRNRRRESRSRSRSTNTAVS 66
R + K + +K R +KE +R + +E K R+ E
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE------ 377
Query: 67 RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI 126
+ R E ++I R + ++ EK + +EE+++ E + + + ++QE E K+
Sbjct: 378 KMRRQEEMMWEKEEKI----RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 433
Query: 127 EEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAA 186
+E R +E + E+++ +++++I + R EE ++ E+ +E + Q E+
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 187 QKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHE-ERMKLEQERQ 245
QK + E+ K + E + KI E + K+ E++ ++ ++ KI E E M E+E+
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKM 553
Query: 246 RQQK---EEQK 253
+Q+ EE+K
Sbjct: 554 HEQEKIWEEEK 564
Score = 69.7 bits (169), Expect = 3e-12
Identities = 59/260 (22%), Positives = 121/260 (46%), Gaps = 30/260 (11%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
R + R + K K R + +E++R++ + K + R R
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR------RQEE 384
Query: 63 TAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIE 122
+ E+ RE ++ K +EK++ EE+ ++ E ++++ + E
Sbjct: 385 MMWEKEEKIRELEEKMHEQ--------EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436
Query: 123 EKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQA 182
EK+ E+E R +E R EE++ + +++I E R+ +E E+++ E+ E RQ
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHE-QEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 183 ELAAQKAREEEERAKREE-----LERILEENNRKIAEAQAKLAEEQLRIVE------EQR 231
E K E+EE+ +++E E + E KI E + K+ ++ +I E E+
Sbjct: 496 E----KMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEE 551
Query: 232 KIHEERMKLEQERQRQQKEE 251
K+HE+ E+E++++Q+++
Sbjct: 552 KMHEQEKIWEEEKRQEQEDK 571
Score = 55.1 bits (131), Expect = 7e-08
Identities = 50/200 (25%), Positives = 92/200 (46%), Gaps = 42/200 (21%)
Query: 91 KRSSLDEKQKREEEEK----------KAEFERQRKI---RQQEIEEKLIEEETARRVEEL 137
K + L EK + E EK K + ER + + +Q + E + +E +L
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281
Query: 138 VAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAK 197
A+ E EL R ++ + E + R EE + E+++ E+ E+ R+ E +K RE+EE+ +
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE---EKIREQEEKMR 338
Query: 198 REE--------------------------LERILEENNRKIAEAQAKLAEEQLRIVEEQR 231
R+E E ++ E K+ + + E++ +I E +
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398
Query: 232 KIHEERMKLEQERQRQQKEE 251
K+HE+ EQE +RQ++E+
Sbjct: 399 KMHEQEKIREQEEKRQEEEK 418
Score = 54.7 bits (130), Expect = 9e-08
Identities = 53/245 (21%), Positives = 114/245 (46%), Gaps = 42/245 (17%)
Query: 11 RSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESR-----SRSRSTNTAV 65
R + K + +K R++E++ ++ K E ++ + +E + + R V
Sbjct: 527 REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKV 586
Query: 66 SRRERD-RERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEI--- 121
R+E RE+ ++ + + K +EK + +EE+ + E++ KIR+QE
Sbjct: 587 WRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIR---EQEEKIREQEEMTQ 643
Query: 122 ---------EEKLIEEETARRVEELVAKRVEEELEKRKDEI--EREVLRRVEEAKRIMEK 170
EEK+ E+E + +E R EE++ +++ +I + E +R EE + E+
Sbjct: 644 EQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 703
Query: 171 QLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQ 230
++ E+ E+ + E Q+ +EE+ R + E K+ E+++R+ +++
Sbjct: 704 KMWEQEEKMCEQEEKMQE-QEEKMRRQEE------------------KMWEQEVRLRQQE 744
Query: 231 RKIHE 235
K+ E
Sbjct: 745 EKMQE 749
Score = 49.7 bits (117), Expect = 3e-06
Identities = 40/155 (25%), Positives = 78/155 (50%), Gaps = 10/155 (6%)
Query: 102 EEEEKKAEFERQRKIRQQEIEEKLIE---EETARRVEELVAKRVEEELEKRKDEIEREVL 158
+EE K+ + Q K++ E E+ I+ +E R++E +++L+ D + +E+
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQ 275
Query: 159 RRVEEAK-RIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQA 217
+ + ++ E +L L +Q++ ++ Q+ + +E K +E E + E KI E
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ-- 333
Query: 218 KLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQ 252
EE++R EE EE+M+ QE +KEE+
Sbjct: 334 ---EEKMRRQEEMMWEKEEKMR-RQEEMMWEKEEK 364
Score = 46.6 bits (109), Expect = 2e-05
Identities = 33/158 (20%), Positives = 81/158 (51%), Gaps = 6/158 (3%)
Query: 99 QKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIE---R 155
QK++ + E ++R E+ I +E + + ++++ +E K EI+ +
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL-VESEKSEIQLNVK 245
Query: 156 EVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEA 215
E+ R++E AK ++ +Q L+ EL + A+ + + + E R+ ++ K+
Sbjct: 246 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 305
Query: 216 QAKLAEEQLRIVEEQRK-IHEERMKLEQERQRQQKEEQ 252
+ K+ E + +I +EQ + I E+ K+ ++ ++ +++E+
Sbjct: 306 EEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEE 342
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 84.3 bits (207), Expect = 1e-16
Identities = 72/268 (26%), Positives = 130/268 (48%), Gaps = 38/268 (14%)
Query: 2 GRSRSRSSSRS-----KHTKSSKHNKKRSRSRSRSR-DKERVRKRSKSRESKRNRRRESR 55
GR S+ S RS H + +++R R R R + +KER R R + RE +R + +R
Sbjct: 52 GRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNR 111
Query: 56 SRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQR- 114
+R R T + ERDRER EKQK E E+ ER+R
Sbjct: 112 NRDREKQTEI---ERDRER----------------------EKQKGRERERDRGRERERD 146
Query: 115 KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLE 174
+ R++E E + ++ +R E +R E ++++ E ER+ R + ++ E+Q
Sbjct: 147 RDREKERERQTEKDRDGQRETETERERDREREKQKERETERD-RDRQRDTEKERERQTDR 205
Query: 175 ELERQRQAELAAQKAREEE-ERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKI 233
E +RQR+ + Q+ + E ER ER + + K + + EE+ +++RK
Sbjct: 206 ERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEER----KKERKK 261
Query: 234 HEERMKLEQERQRQQKEEQKIILGKGKS 261
++ + E++++ +++E++K G+G S
Sbjct: 262 ERKKERKEKKKEEKRREDKKRKWGEGIS 289
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/224 (29%), Positives = 113/224 (50%), Gaps = 24/224 (10%)
Query: 4 SRSRSSSRSKHT-KSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
SRSRS SR + T SS+H + RSRSR RS K R R+RSKS +R+ RE RSRST+
Sbjct: 249 SRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTS 308
Query: 63 TAVSRRERDRE--RASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQE 120
+++ D+E R+ +PP R+ RS+ E+++R ++ R ++
Sbjct: 309 KTRDKKKEDKEKKRSKTPPKSYSTARRS---RSASRERRRRRSRSGTRSPKKPRSPKR-- 363
Query: 121 IEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQR 180
KL + RR ++ K+ +++ E+ +DE ER ++ +K +E +R+R
Sbjct: 364 ---KLSRSPSPRRHKK--EKKKDKDKERSRDERERSTSKK--------KKSKDKEKDRER 410
Query: 181 QAEL---AAQKAREEEERAKREELERILEENNRKIAEAQAKLAE 221
++E Q R+ +E + + E+ +E + I K E
Sbjct: 411 KSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKE 454
Score = 64.3 bits (155), Expect = 1e-10
Identities = 67/243 (27%), Positives = 107/243 (44%), Gaps = 21/243 (8%)
Query: 1 MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS 60
M R R S S + K +KR SRSRSR + R ++ S R+RR SRSR RS
Sbjct: 223 MKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRR-----RTPSSSRHRRSRSRSRRRS 277
Query: 61 TNTAVSRR--ERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQ 118
+ + SRR + R R S +R GR S+ +S +K+E++EKK +
Sbjct: 278 HSKSRSRRRSKSPRRRRSHSRER----GRR-SRSTSKTRDKKKEDKEKKRSKTPPKSYST 332
Query: 119 QEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELER 178
E RR + KRK R +E K+ +K+ + ER
Sbjct: 333 ARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRD-ER 391
Query: 179 QRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERM 238
+R + +E++R ++ E ++ +++ R E EEQ E+++K EE+
Sbjct: 392 ERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDE------EEQGYDSEKEKK--EEKK 443
Query: 239 KLE 241
+E
Sbjct: 444 PIE 446
Score = 52.0 bits (123), Expect = 6e-07
Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 6/125 (4%)
Query: 5 RSRSSSRSKHTKSSKHN-----KKRSRSRSRSRDKE-RVRKRSKSRESKRNRRRESRSRS 58
RSRS+SR + + S+ K RS R SR R K+ K ++ + R R+ R RS
Sbjct: 335 RSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERS 394
Query: 59 RSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQ 118
S +E+DRER S + R + + +K ++EEKK K ++
Sbjct: 395 TSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKE 454
Query: 119 QEIEE 123
+E+
Sbjct: 455 CSVEK 459
Score = 51.2 bits (121), Expect = 9e-07
Identities = 54/252 (21%), Positives = 111/252 (44%), Gaps = 21/252 (8%)
Query: 12 SKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRS-----TNTAVS 66
S KS +K+ + R R+ + + + + K +RR SRSRSRS +++
Sbjct: 207 SPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRH 266
Query: 67 RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQ-RKIRQQEIEEKL 125
RR R R R S ++ S+R S +++R ++ R K R ++ E+K
Sbjct: 267 RRSRSRSRRRS-------HSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKE 319
Query: 126 IEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELA 185
+ A+R +R+ R R ++ + K R+ + E
Sbjct: 320 KKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKE-- 377
Query: 186 AQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQ--E 243
K +++++ R+E ER + +K ++ + K E + ++ +++ + + EQ +
Sbjct: 378 --KKKDKDKERSRDERER--STSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYD 433
Query: 244 RQRQQKEEQKII 255
++++KEE+K I
Sbjct: 434 SEKEKKEEKKPI 445
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 84.3 bits (207), Expect = 1e-16
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 9/228 (3%)
Query: 32 RDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERA----SSPPDRIDIFGR 87
RD+ R+ + +R R+ R T S E + E P +++ G
Sbjct: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE 349
Query: 88 TVSKRSSL---DEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEE 144
+ +R L E ++R E ++ + +++++R+QE ++ + E +R+E+ +R
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 145 ELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREE--LE 202
E ++R++ R R + + EK+ LEELER+R+ E ++A EE+ R +RE+ +
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR 469
Query: 203 RILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
R LEE R + Q +L +EQ ++ + R+ H + + Q+++ +
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 52.8 bits (125), Expect = 3e-07
Identities = 53/224 (23%), Positives = 97/224 (43%), Gaps = 31/224 (13%)
Query: 8 SSSRSKHTKSSKHNKKRSRSRSRS--------RDKERVRK-----RSKSRESKRNRRRES 54
S+ R + + NK+RS + R R++E ++ R K E ++ +RR
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 55 RSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQR 114
+ R A ++ER++ R R + L+ ++K EEE ++AE E++R
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKR---------RLEELERRRKEEEERRRAEEEKRR 460
Query: 115 KIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLE 174
R+QE + +EEE R +E L + ++E+ D RR + ++
Sbjct: 461 VEREQEYIRRQLEEE-QRHLEVLQQQLLQEQAMLLHDH------RRPH--PQHSQQPPPP 511
Query: 175 ELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAK 218
+ ER + + A + E + E+E + N EAQ+K
Sbjct: 512 QQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSK 555
Score = 30.0 bits (66), Expect = 2.3
Identities = 15/71 (21%), Positives = 28/71 (39%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
+ R + + ++R R + R++ R + K R + RRR+ R
Sbjct: 396 QKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAE 455
Query: 63 TAVSRRERDRE 73
R ER++E
Sbjct: 456 EEKRRVEREQE 466
Score = 28.9 bits (63), Expect = 5.0
Identities = 42/189 (22%), Positives = 65/189 (34%), Gaps = 33/189 (17%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R S S S + S S+S S ++ RVR SKS S S+ A
Sbjct: 644 RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSP----------SQRLENA 693
Query: 65 VSRRERDRE--RASSPPDRIDIFGRTVSKRSSLDEKQKRE-------EEEKKAEFERQRK 115
V + E +E R P +D+ R+ D + + EE E
Sbjct: 694 VKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDD 753
Query: 116 IRQQEIEEKLIEEETARRVEELVAKRVEEELEKR---KDEIERE-----------VLRRV 161
+ Q+ +E E R L E E K D++E E ++R+
Sbjct: 754 VEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQT 813
Query: 162 EEAKRIMEK 170
+ A ++K
Sbjct: 814 QSASSTLQK 822
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 84.3 bits (207), Expect = 1e-16
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 9/228 (3%)
Query: 32 RDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERA----SSPPDRIDIFGR 87
RD+ R+ + +R R+ R T S E + E P +++ G
Sbjct: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE 349
Query: 88 TVSKRSSL---DEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEE 144
+ +R L E ++R E ++ + +++++R+QE ++ + E +R+E+ +R
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 145 ELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREE--LE 202
E ++R++ R R + + EK+ LEELER+R+ E ++A EE+ R +RE+ +
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIR 469
Query: 203 RILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKE 250
R LEE R + Q +L +EQ ++ + R+ H + + Q+++ +
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517
Score = 50.8 bits (120), Expect = 1e-06
Identities = 39/151 (25%), Positives = 72/151 (47%), Gaps = 23/151 (15%)
Query: 8 SSSRSKHTKSSKHNKKRSRSRSRS--------RDKERVRK-----RSKSRESKRNRRRES 54
S+ R + + NK+RS + R R++E ++ R K E ++ +RR
Sbjct: 350 STLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRL 409
Query: 55 RSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQR 114
+ R A ++ER++ R R + L+ ++K EEE ++AE E++R
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKR---------RLEELERRRKEEEERRRAEEEKRR 460
Query: 115 KIRQQEIEEKLIEEETARRVEELVAKRVEEE 145
R+QE + +EEE R +E L + ++E+
Sbjct: 461 VEREQEYIRRQLEEE-QRHLEVLQQQLLQEQ 490
Score = 30.0 bits (66), Expect = 2.3
Identities = 15/71 (21%), Positives = 28/71 (39%)
Query: 3 RSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTN 62
+ R + + ++R R + R++ R + K R + RRR+ R
Sbjct: 396 QKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAE 455
Query: 63 TAVSRRERDRE 73
R ER++E
Sbjct: 456 EEKRRVEREQE 466
Score = 28.9 bits (63), Expect = 5.0
Identities = 42/189 (22%), Positives = 65/189 (34%), Gaps = 33/189 (17%)
Query: 5 RSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTA 64
R S S S + S S+S S ++ RVR SKS S S+ A
Sbjct: 590 RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSP----------SQRLENA 639
Query: 65 VSRRERDRE--RASSPPDRIDIFGRTVSKRSSLDEKQKRE-------EEEKKAEFERQRK 115
V + E +E R P +D+ R+ D + + EE E
Sbjct: 640 VKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDD 699
Query: 116 IRQQEIEEKLIEEETARRVEELVAKRVEEELEKR---KDEIERE-----------VLRRV 161
+ Q+ +E E R L E E K D++E E ++R+
Sbjct: 700 VEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQT 759
Query: 162 EEAKRIMEK 170
+ A ++K
Sbjct: 760 QSASSTLQK 768
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.121 0.294
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,194,505
Number of Sequences: 37866
Number of extensions: 497199
Number of successful extensions: 44181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1286
Number of HSP's successfully gapped in prelim test: 1392
Number of HSP's that attempted gapping in prelim test: 6307
Number of HSP's gapped (non-prelim): 13981
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.