Search of human proteins with 134152674

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134152674 rabaptin, RAB GTPase binding effector protein 1
isoform 2 [Homo sapiens]
         (829 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso...  1591   0.0  
gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof...  1574   0.0  
gi|117956403 rabaptin, RAB GTPase binding effector protein 2 [Ho...   214   2e-55
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    105   1e-22
gi|21735548 centrosomal protein 2 [Homo sapiens]                      105   2e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   102   2e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   102   2e-21
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   100   4e-21
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   100   4e-21
gi|118498368 kinectin 1 isoform c [Homo sapiens]                      100   7e-21
gi|71061468 centromere protein E [Homo sapiens]                       100   7e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                99   2e-20
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        99   2e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        99   2e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         99   2e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         99   2e-20
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         99   2e-20
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         99   2e-20
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         99   2e-20
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         99   2e-20
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    96   1e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    96   1e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    96   1e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     96   2e-19
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       96   2e-19
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               96   2e-19
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       94   4e-19
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        94   4e-19
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    93   1e-18
gi|148746195 trichohyalin [Homo sapiens]                               93   1e-18

>gi|134152674 rabaptin, RAB GTPase binding effector protein 1
           isoform 2 [Homo sapiens]
          Length = 829

 Score = 1591 bits (4119), Expect = 0.0
 Identities = 829/829 (100%), Positives = 829/829 (100%)

Query: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60
           MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
Sbjct: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60

Query: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120
           NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
Sbjct: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120

Query: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180
           MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
Sbjct: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180

Query: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240
           AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
Sbjct: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240

Query: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
           LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
Sbjct: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300

Query: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
           MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
Sbjct: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360

Query: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
           LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
Sbjct: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420

Query: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
           ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
Sbjct: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480

Query: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
           PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
Sbjct: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540

Query: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600
           KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
Sbjct: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600

Query: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660
           LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
Sbjct: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660

Query: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720
           SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
Sbjct: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720

Query: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDV 780
           ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDV
Sbjct: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDV 780

Query: 781 SEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 829
           SEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
Sbjct: 781 SEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 829


>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform
           1 [Homo sapiens]
          Length = 862

 Score = 1574 bits (4075), Expect = 0.0
 Identities = 829/862 (96%), Positives = 829/862 (96%), Gaps = 33/862 (3%)

Query: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60
           MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ
Sbjct: 1   MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQ 60

Query: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120
           NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV
Sbjct: 61  NAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV 120

Query: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180
           MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED
Sbjct: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180

Query: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240
           AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV
Sbjct: 181 AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240

Query: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
           LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR
Sbjct: 241 LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300

Query: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
           MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ
Sbjct: 301 MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360

Query: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420
           LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK
Sbjct: 361 LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSK 420

Query: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
           ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT
Sbjct: 421 ALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480

Query: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
           PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE
Sbjct: 481 PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540

Query: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600
           KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV
Sbjct: 541 KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600

Query: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660
           LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV
Sbjct: 601 LRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660

Query: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720
           SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK
Sbjct: 661 SLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLK 720

Query: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ----------------------- 757
           ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ                       
Sbjct: 721 ENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLE 780

Query: 758 ----------ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 807
                     ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS
Sbjct: 781 EQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 840

Query: 808 LERIRAILNDTKLTDINQLPET 829
           LERIRAILNDTKLTDINQLPET
Sbjct: 841 LERIRAILNDTKLTDINQLPET 862


>gi|117956403 rabaptin, RAB GTPase binding effector protein 2 [Homo
           sapiens]
          Length = 569

 Score =  214 bits (546), Expect = 2e-55
 Identities = 188/701 (26%), Positives = 316/701 (45%), Gaps = 160/701 (22%)

Query: 136 LEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED--AEKLRSVVMPMEK 193
           LE  R+Q     E+   E++ LR  L+    E      + +  E   AE + +V    ++
Sbjct: 22  LEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQE 81

Query: 194 EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
           E+A+L+  L   +D I   EA                       +  L  ++   Q+D E
Sbjct: 82  EVASLQAIL---KDSISSYEAQ----------------------ITALKQERQQQQQDCE 116

Query: 254 KLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQV 313
           +  +EL  +  LL +     + L+   +KA++   +S++L        EIVL  E  +++
Sbjct: 117 EKERELGRLKQLLSRAYPL-DSLEKQMEKAHE---DSEKL-------REIVLPME--KEI 163

Query: 314 EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRG 373
           EELK K                                L  EE   ++     H  S  G
Sbjct: 164 EELKAK-------------------------------LLRAEELIQEIQRRPRHAPSLHG 192

Query: 374 SVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGN 433
           S        LLP           + +D     +  + L   G   ++A  +N        
Sbjct: 193 STE------LLP-----------LSRDPSPPLEPLEELSGDGGPAAEAFAHNCD------ 229

Query: 434 LDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV 493
                              D+AS+ S  +  G   +    ++ + ++PEQEETASL+S+ 
Sbjct: 230 -------------------DSASISSFSLGGGVGSSSSLPQSRQGLSPEQEETASLVSTG 270

Query: 494 TQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET 553
           T   E  Y+ P GY+LV +T+W  LQ E                                
Sbjct: 271 TLVPEGIYLPPPGYQLVPDTQWEQLQTEG------------------------------- 299

Query: 554 RDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEEL 613
                      RQ    LE   +++ EL++ +++S+ED + Q+  L+ + Q SE LL  L
Sbjct: 300 -----------RQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNSEQLLRTL 348

Query: 614 QQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ-----QAEDF 668
           Q  +SQA+  VQ QMA L+ + + +  E+ RL ++N  L+ +     + Q     Q E+ 
Sbjct: 349 QGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGSQQEQGEEE 408

Query: 669 ILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ 728
            LP +   L++L+   R++      A +H  E+L+ EI+ L+E ++ E   + +LE  L+
Sbjct: 409 SLPSSVPELQQLLCCTRQEARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLR 468

Query: 729 LEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDF 788
           ++ E  +   AS+ SL+ E+ER++ E+ +A +  L+ E++ K  RLQ EL+ SEQVQRDF
Sbjct: 469 VQREETEVLEASLCSLRTEMERVQQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDF 528

Query: 789 VKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET 829
           V+LSQ LQV+LERIRQA++LE++R+I+++  LTD+  + +T
Sbjct: 529 VRLSQALQVRLERIRQAETLEQVRSIMDEAPLTDVRDIKDT 569



 Score =  137 bits (344), Expect = 5e-32
 Identities = 77/162 (47%), Positives = 109/162 (67%), Gaps = 1/162 (0%)

Query: 52  AKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWR 111
           A E+   ++ A  +A   +L  LR +L  A AEME +KA+A VSE+TK EA+  V+RQ +
Sbjct: 21  ALEDSRSQEGANGEAESGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQ 80

Query: 112 EEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLE 171
           EEVASLQA++K+++  YE Q    L+QER Q  Q  E  ERE+  L++ LS     ++LE
Sbjct: 81  EEVASLQAILKDSISSYEAQI-TALKQERQQQQQDCEEKERELGRLKQLLSRAYPLDSLE 139

Query: 172 NEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE 213
            +M+KA ED+EKLR +V+PMEKEI  LK KL  AE+ I+E++
Sbjct: 140 KQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQ 181



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 67/315 (21%), Positives = 120/315 (38%), Gaps = 61/315 (19%)

Query: 22  EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
           E++  E  + Q+ LE   +++R + +E      ED  +Q  VL                 
Sbjct: 293 EQLQTEGRQLQKDLE-SVSRERDELQEGLRRSNEDCAKQMQVL----------------- 334

Query: 82  QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
            A+++N + +    + T  +A + V+ Q  E V + + +  E  R  E    LR EQ   
Sbjct: 335 LAQVQNSEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQ--- 391

Query: 142 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 201
                          L     +G ++E         Q + E L S V  +++ +   + +
Sbjct: 392 ---------------LPSSAPQGSQQE---------QGEEESLPSSVPELQQLLCCTRQE 427

Query: 202 L---TEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKE 258
                +A++   E    ++  L   LE E   R  LE  + V   +  VL+     LR E
Sbjct: 428 ARARLQAQEHGAERLRIEIVTLREALEEETVARASLEGQLRVQREETEVLEASLCSLRTE 487

Query: 259 LHEVCHLLEQERQQHNQLKHTWQKANDQF------LESQRLLMRDMQRME--IVLTSEQL 310
           +  V     Q+ Q   QL     +   +       LE+   + RD  R+   + +  E++
Sbjct: 488 MERV-----QQEQSKAQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERI 542

Query: 311 RQVEELKKKDQEDDE 325
           RQ E L++     DE
Sbjct: 543 RQAETLEQVRSIMDE 557


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  105 bits (263), Expect = 1e-22
 Identities = 182/878 (20%), Positives = 380/878 (43%), Gaps = 132/878 (15%)

Query: 15   QQRVAELE-KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNA--VLQAAQDDL 71
            ++ +A+L  +I     + ++  EQ+   +RA F+EL  A     K + A   L+A  D+ 
Sbjct: 381  EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE- 439

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
               + +  E  +E E I     +S   KQE +D +K+   E++A LQ + ++ +   E +
Sbjct: 440  ---QIKTIEKTSEEERISLQQELSR-VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQE 495

Query: 132  FHLRLE-QERTQWAQYRESAEREIADLRRRLSEGQEEENL----------------ENEM 174
               +L+ +ER    Q + + E+  ++  +   E +++E+L                EN++
Sbjct: 496  LTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555

Query: 175  KKAQEDAEKLRSVVMPMEKEIA-ALKDKLTEAEDKIKELEASKVK---ELNHYLEAEKSC 230
            +  Q++AE  R+ ++ +E  +  +L++   +++D    LEA K K   E+   +E  K+ 
Sbjct: 556  RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615

Query: 231  RTDLEMYVAVLNTQK-SVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE 289
               L+     L T+K  VL++  +   ++L E C   EQE++   + K    +A+ + + 
Sbjct: 616  LESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC---EQEKETLLKDKEIIFQAHIEEMN 672

Query: 290  SQRLLMRDMQRMEIVLTSEQLRQV--------EELKK-KDQEDDEQQRL----NKRKDHK 336
             + L   D+++ E+   S +L +V        EEL   KDQ D  +Q L    +++K+H 
Sbjct: 673  EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNE--------EEHLDSTRGSVHSLDAGLLLPSGD 388
            +  V+  IK   V     E++     N+        ++HL   +  V +L+A +    G+
Sbjct: 733  QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792

Query: 389  PFSKSDN-DMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
                S   D+F+          S  ++   Q+KA      A+    L + +   ++    
Sbjct: 793  LQQASAKLDVFQ----------SYQSATHEQTKAYEEQL-AQLQQKLLDLETERILLTKQ 841

Query: 448  VSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGM--ESAYVSPS 505
            V+E          ++ +  +  +D  + ++    E E+    L+ V +    +       
Sbjct: 842  VAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ 901

Query: 506  GYRLVSETEWNLLQ------KEVHNAGNKLGRRCD----MCSNYEKQLQGIQIQEAETRD 555
              +++ E E  +LQ      KE+     KL  + D    +   YE + +  + +  + + 
Sbjct: 902  TKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ 961

Query: 556  QVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQ 615
            + K++Q  L++    L++  K K+ELE+   + S+      + ++  AQA+   + +   
Sbjct: 962  KAKEMQETLKKK--LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISD--- 1016

Query: 616  GLSQAKRDVQEQMAVLMQSREQVSEELVRL--QKDNDSLQGKHSLH-VSLQQAEDFILPD 672
             +S+ + + +EQ+  L +   +   +++ +  +K N   +    +H + LQ+ E     +
Sbjct: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ----E 1072

Query: 673  TTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIE 732
              E  ++++L   E            +E++  EI +LKE+   +      L+E L+ +  
Sbjct: 1073 VAELKQKILLFGCE------------KEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120

Query: 733  NCKEEIASISSLKAELERIKVEKGQATVE------------QLMFEEKNKAQRLQTELDV 780
            +        + LKA LE+++V+  ++  E             L  E+K K   L ++L  
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180

Query: 781  S------------------EQVQRDFVKLSQTLQVQLE 800
            +                  E    +F KLS+ L +QL+
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLD 1218



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 171/885 (19%), Positives = 352/885 (39%), Gaps = 137/885 (15%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL--YLAKEEDLKRQNAVLQ 65
            S+ +  L+Q   E   +N  F +A  QLE++ NQ ++   ++   + ++E L+++    Q
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQ 1331

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQE------------------------ 101
             A  +     TQL +  +E  NI A+  + E  K++                        
Sbjct: 1332 QAASEKESCITQLKKELSE--NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389

Query: 102  -----AIDEVKRQWREEVASLQAVMK-----------------ETVRDYEHQFHLRLEQE 139
                 AI  +++Q+ EE   L   ++                 E V D+ ++F    ++ 
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449

Query: 140  RTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKA---------------QEDAEKL 184
            ++++ Q++ + +     L  +  E  E++   N +K+                ++D  K+
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509

Query: 185  RSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQ 244
                  +E E+ +   ++ E ED I + +  +++ LN  L+     + D+E    V   Q
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHITQ-KTIEIESLNEVLKNYNQ-QKDIEHKELVQKLQ 1567

Query: 245  K-SVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEI 303
                L E+ +   KE  E    LE +         T +K  +    S +    +++ +E 
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSN 363
             L SE   ++ ELK+K ++  +   + K+   +  + EE+ K      L++  +  Q   
Sbjct: 1628 RLESESAAKLAELKRKAEQ--KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE 1685

Query: 364  EEEH-LDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKAL 422
             E H L+    SV S  +  L+    P S  +   + +     +  DS G       + +
Sbjct: 1686 REVHILEEKLKSVESSQSETLIV---PRSAKNVAAYTE----QEEADSQGCVQKTYEEKI 1738

Query: 423  GYNYKAKSAGNLDESD-FGPLVGAD---SVSENFDTASLGSLQMPSGFMLTKDQERAIKA 478
                +     NL E +     VG +   +VS +F+             M  + QER IK 
Sbjct: 1739 SVLQR-----NLTEKEKLLQRVGQEKEETVSSHFE-------------MRCQYQERLIKL 1780

Query: 479  MTPE--QEETASLLSSVTQGME----------SAYVSPSGYRLVSETEWNL--LQKEVHN 524
               E  Q E  S++  + + +E          + +V   G +   + + NL  +  +V  
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840

Query: 525  AGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
               +    C +     K+L    +++ E   +V+  +L  +    Q  + M  + +  + 
Sbjct: 1841 TLQEKELTCQILEQKIKELDSCLVRQKEVH-RVEMEELTSKYEKLQALQQMDGRNKPTEL 1899

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR 644
            +++++E+ S            S ++  +L   +     D++ ++A   + ++++ +E+VR
Sbjct: 1900 LEENTEEKSK-----------SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948

Query: 645  LQKDNDSLQGKHSLHVSL------QQAEDFIL--PDTTEALRELVLKYREDIINVRTAAD 696
            LQKD   L+ +H   + +      Q+ E+ I    +  E      LK      N + A  
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008

Query: 697  HVEEKLKAEILFLKEQIQAEQCLKENLEETLQL--EIENCKEEIASISSLKAELERIKVE 754
              E ++  +    K Q    + L+ + EET QL  +I    +++   +    E+   + E
Sbjct: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068

Query: 755  KGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQL 799
            +  A V  L  + +   ++ Q +L+  E    D V + + LQ QL
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIME-LQTQL 2112



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 179/854 (20%), Positives = 341/854 (39%), Gaps = 103/854 (12%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKF--------KELYLAKEEDLKRQNAVLQ 65
            L Q+  EL++I+   L+ ++Q   E  QK   F        KE+   KEE +K+      
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTT--- 1107

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETV 125
                 L  L+ QL +  A + ++             A DE K   +  +  L+  + +++
Sbjct: 1108 -----LNELQEQLKQKSAHVNSL-------------AQDETKL--KAHLEKLEVDLNKSL 1147

Query: 126  RDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE-ENLENEMKKAQEDAEKL 184
            +  E+ F   L+++  +     E  +R++++L  +L    EE ++L++  +K+ +  E  
Sbjct: 1148 K--ENTF---LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDK 1202

Query: 185  RSVVMPMEKEIAALKD---KLTEA--EDKIKELE----------ASKVKELNHYLEAEKS 229
                  + +E+A   D   K TEA  E K  EL            S++    H     K 
Sbjct: 1203 SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262

Query: 230  CRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE 289
                    V+ L  Q   L E+   L     +  H LE++    NQ+K    KA+ + L 
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKE---NQIKS--MKADIESLV 1317

Query: 290  SQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVV 349
            +++  ++     +    SE+   + +LKK+  E+     L K +  +K      +   + 
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377

Query: 350  CALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSD--------------- 394
                Q ++S  LS +E  + S R         LL    D   K D               
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437

Query: 395  -NDMFKDGLRRAQS--TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSEN 451
             ++ F +  ++AQS  T    T   LQ   +    K+K A   DE         D  ++ 
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQ---IQLELKSKEAYEKDEQINLLKEELDQQNKR 1494

Query: 452  FDTASLGSLQMPSGFMLTKDQ--ERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL 509
            FD    G ++     M  K+   E  +K+ T    E    ++  T  +ES       Y  
Sbjct: 1495 FDCLK-GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ 1553

Query: 510  VSETEWN-LLQKEVH------NAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQL 562
              + E   L+QK  H         N++    +     E Q+  ++ +    + +++ + L
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613

Query: 563  MLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
             ++   ++L K ++D+ E E   K +      +     ++ Q    LL ++++   Q K+
Sbjct: 1614 SVKSKEEEL-KALEDRLESESAAKLAELKRKAEQKIAAIKKQ----LLSQMEEKEEQYKK 1668

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRE--- 679
              +  ++ L    ++   E+  L++   S++   S  + + ++   +   T +   +   
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728

Query: 680  LVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAE--QCLKENLEETLQLEIENCK-- 735
             V K  E+ I+V       +EKL   +   KE+  +   +   +  E  ++LE    K  
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQH 1788

Query: 736  EEIASISSLKAELERIKVEKGQATVEQLMFEE--KNKAQRLQTELDVSEQVQRDFVKLSQ 793
            E+ + I  L+ ELE  K +K    V Q + +E  KN  Q  Q   +V + VQ+   +   
Sbjct: 1789 EDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKEL 1847

Query: 794  TLQVQLERIRQADS 807
            T Q+  ++I++ DS
Sbjct: 1848 TCQILEQKIKELDS 1861



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 168/879 (19%), Positives = 365/879 (41%), Gaps = 111/879 (12%)

Query: 5    GPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVL 64
            G  SQ      +R+AEL +      +A++ L++EF+    + K+ Y++    L+ Q ++L
Sbjct: 176  GILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEE-KDQYISV---LQTQVSLL 231

Query: 65   QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVK-----------RQWREE 113
            +    + G +   + +   ++E    + T  EN + +    V+           +Q  + 
Sbjct: 232  KQRLRN-GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKR 290

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAER-------EIADLRRRLSEGQE 166
              +L    KET++ ++ Q  L   ++     Q  E  +         +A+  + +++ ++
Sbjct: 291  QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350

Query: 167  EENLENEMKKAQ-----EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVK-EL 220
             +NL  ++++ +     E   ++   +   E+EIA L+ ++ +   + +EL   K K E 
Sbjct: 351  AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410

Query: 221  NHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE--RQQHNQLKH 278
              + E EK+  T  +   A     K+ + E  + + K   E    L+QE  R +   +  
Sbjct: 411  AAFEELEKALSTAQKTEEA-RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469

Query: 279  TWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKK-----DQEDDEQQRLNKRK 333
              + + +Q  + Q+L  +++ R E  LT +   +  E +++     ++   E  ++++ K
Sbjct: 470  MKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529

Query: 334  DHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKS 393
            + +++   EE+++     LT+ E+  +L + ++  ++ R  +  L++ L         KS
Sbjct: 530  EQQESLALEELELQKKAILTESEN--KLRDLQQEAETYRTRILELESSL--------EKS 579

Query: 394  DNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFD 453
              +        A   ++     + +   +   +K +      + D         + + + 
Sbjct: 580  LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639

Query: 454  T--ASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQ------GMESAYVSPS 505
            T    L          L KD+E   +A   E  E       V Q        E + V  +
Sbjct: 640  TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699

Query: 506  GYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQL---------QGIQIQEAETRDQ 556
             ++L  E E ++L+ +      +L  + D   N+ +Q            IQ  E   +DQ
Sbjct: 700  RHKL--EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757

Query: 557  VKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED-----------SSHQISALVLRAQA 605
            + +L+L+L++ +  L++     + LE  IK+S  +            S+Q SA   + +A
Sbjct: 758  INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ-SATHEQTKA 816

Query: 606  SEILLEELQQGLSQAKRD---VQEQMAVLMQSREQVSEEL-----------VRLQKDNDS 651
             E  L +LQQ L   + +   + +Q+A +   ++ V  EL            +L+K N  
Sbjct: 817  YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876

Query: 652  LQGKHSLHVSLQQAEDFILPD---TTEALRELVLKYREDIINVRTAADHVEEKLKAEILF 708
            ++ K     SL Q  +  L D     E  ++++++    I+ +R       E  K EI  
Sbjct: 877  MEQKVK---SLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR-------EGQKKEIEI 926

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEK 768
            L +++ A++     L E  + + +N ++++  +     E++    +K       L  E K
Sbjct: 927  LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK------LLDQEAK 980

Query: 769  NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADS 807
             K +   T L++S++ ++   K+ +  Q     I  A S
Sbjct: 981  LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVS 1019



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 176/884 (19%), Positives = 367/884 (41%), Gaps = 156/884 (17%)

Query: 12   VSLQQRVAELE--------KINAEFLRAQ---QQLEQ---EFNQKRAKFKELYLAKEED- 56
            + L ++VAE+E        +++A  ++ Q   QQLE+   E  QK     ++Y +K ED 
Sbjct: 836  ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895

Query: 57   -----------LKRQNAVLQ----------------AAQDDLGHLRTQLWEAQAEMENIK 89
                       ++++N +LQ                +A++D  H+  + +E + + +  K
Sbjct: 896  NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQE-K 954

Query: 90   AIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDY---EHQFHLRL---------- 136
             +  V +  K E  + +K++  ++ A L+  ++ T  +    E QF+ ++          
Sbjct: 955  KMEKVKQKAK-EMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013

Query: 137  ---------EQERTQWAQYRESAEREIADL----RRRLSEGQEEENLENEM---KKAQED 180
                       ++ Q     E   RE+ D+     ++L++  EE    +E+   +K QE 
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEV 1073

Query: 181  AEKLRSVVM------PMEKEIAALKDKLTEAEDKIKELE---ASKVKELNHYLEAEKSCR 231
            AE  + +++       M KEI  LK++  + +  + EL+     K   +N   + E   +
Sbjct: 1074 AELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK 1133

Query: 232  TDLEMYVAVLN---TQKSVLQED-------AEKLRKELHEVCHLLEQERQQHNQLKHTWQ 281
              LE     LN    + + LQE        AE+ ++++ E+   L+   ++   LK + +
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193

Query: 282  KAN----DQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLN------K 331
            K+N    D+ LE ++L   +   +++ +  ++   + E K  +  +    + N       
Sbjct: 1194 KSNKSLEDKSLEFKKL--SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRIS 1251

Query: 332  RKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD-STRGSVHSLD-----AGLLLP 385
               H+   V+E + I        E    QL+ E+  L+ S + + H L+        +  
Sbjct: 1252 HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311

Query: 386  SGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA 445
              +        + K+G  + Q+     +  +   K L  N  A +   + E      V  
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL--MKEELKEKKVEI 1369

Query: 446  DSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPS 505
             S+S+        ++Q+ +   L+ ++E AI ++  + +E    L    Q +        
Sbjct: 1370 SSLSKQLTDL---NVQLQNSISLS-EKEAAISSLRKQYDEEKCELLDQVQDL-------- 1417

Query: 506  GYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLR 565
                    + + L KE  +A  ++    +  S ++K+ Q    Q   T   VK+LQ+ L 
Sbjct: 1418 ------SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT---VKELQIQL- 1467

Query: 566  QANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQ 625
               +   K   +K E  + +K+  +  + +   L    +  +  +E+ +  L   + +++
Sbjct: 1468 ---ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL---ETELK 1521

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSL----QGKHSLHVSLQQAEDFILPDTTEALRELV 681
             Q A +M+  + ++++ + ++  N+ L    Q K   H  L Q     L    E   E  
Sbjct: 1522 SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK----LQHFQELGEEKD 1577

Query: 682  LKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASI 741
             + +E    + T  + V   +KAE+   K++++      ++ EE    E++  ++ + S 
Sbjct: 1578 NRVKEAEEKILTLENQV-YSMKAELETKKKELEHVNLSVKSKEE----ELKALEDRLESE 1632

Query: 742  SSLK-AELERIKVEKGQATVEQLM--FEEKNKAQRLQTELDVSE 782
            S+ K AEL+R   +K  A  +QL+   EEK +  +  TE  +SE
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSE 1676



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 149/765 (19%), Positives = 310/765 (40%), Gaps = 125/765 (16%)

Query: 121 MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180
           +K+ + + + Q    L   +   A    S    +       +E  +E     E    Q  
Sbjct: 5   LKQKISEEQQQLQQALAPAQ---ASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSF 61

Query: 181 AEKLRSVVMPMEKEIAA-LKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVA 239
           A+KL+  V  +E    + +K+ L  +  K   +  S  + LN         R DL+   A
Sbjct: 62  AQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLN---------RLDLDSSTA 112

Query: 240 V------LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
                  ++++   L  +++ L KE      L+++ R+    L  +++    + + + ++
Sbjct: 113 SFDPPSDMDSEAEDLVGNSDSLNKE-----QLIQRLRRMERSLS-SYRGKYSELVTAYQM 166

Query: 294 LMRDMQRMEIVLTSEQ---LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEE------- 343
           L R+ ++++ +L+  Q   LR++ EL+++ Q D  QQ     ++   A +EE+       
Sbjct: 167 LQREKKKLQGILSQSQDKSLRRIAELREELQMD--QQAKKHLQEEFDASLEEKDQYISVL 224

Query: 344 ---------------IKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
                          + + V+  L Q E  A++  +EE+ +S    V  ++ G  + + +
Sbjct: 225 QTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPV--VEDGTSVKTLE 282

Query: 389 PFS---KSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA 445
                 K   ++ K      QS     T  + + +AL      +        D       
Sbjct: 283 TLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKT 342

Query: 446 DSVSENFDTASL-GSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSP 504
             +++  D  +L   L+   G ++ + + +  + +  ++EE A L S + Q      ++ 
Sbjct: 343 KLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQ------MTT 396

Query: 505 SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLML 564
            G  L  + E     K    A  +L +        E+  + ++   AE  +Q+K ++   
Sbjct: 397 QGEELREQKE-----KSERAAFEELEKALSTAQKTEEARRKLK---AEMDEQIKTIEKTS 448

Query: 565 RQANDQLEKTM-KDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRD 623
            +    L++ + + KQE+ D +K+SSE+   ++  L  +  A +   +EL + L   +R+
Sbjct: 449 EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE--QELTKKLQTRERE 506

Query: 624 VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLK 683
            QEQM V +   E+   E +++ ++ +  +      + LQ+    IL ++   LR+L  +
Sbjct: 507 FQEQMKVAL---EKSQSEYLKISQEKEQQESLALEELELQKKA--ILTESENKLRDLQQE 561

Query: 684 ---YREDIINVRTAAD---------------HVE--------------EKLKAEILFLKE 711
              YR  I+ + ++ +               H+E              EK K E+  LK 
Sbjct: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621

Query: 712 QIQAE-----QCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFE 766
           Q  A      Q LK+  +  ++   E C++E       K  L + K    QA +E++  +
Sbjct: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQE-------KETLLKDKEIIFQAHIEEMNEK 674

Query: 767 EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIR-QADSLER 810
              K    QTEL+       + +K    L+ +L  ++ Q D +++
Sbjct: 675 TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 137/666 (20%), Positives = 268/666 (40%), Gaps = 89/666 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLE---QEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            + Q+  E+E +N       QQ +   +E  QK   F+EL   K+  +K        A++ 
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKE-------AEEK 1586

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEH 130
            +  L  Q++  +AE+E           TK++ ++ V    + +   L+A+          
Sbjct: 1587 ILTLENQVYSMKAELE-----------TKKKELEHVNLSVKSKEEELKALED-------- 1627

Query: 131  QFHLRLEQE-RTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM 189
                RLE E   + A+ +  AE++IA ++++L   Q EE  E   K  +    +L + + 
Sbjct: 1628 ----RLESESAAKLAELKRKAEQKIAAIKKQLL-SQMEEKEEQYKKGTESHLSELNTKLQ 1682

Query: 190  PMEKEIAALKDKLTEAEDKIKE--LEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQK-S 246
              E+E+  L++KL   E    E  +     K +  Y E E++   D +  V     +K S
Sbjct: 1683 EREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA---DSQGCVQKTYEEKIS 1739

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK-------ANDQFLESQRLLMRDMQ 299
            VLQ +  +  K L  V    E+    H +++  +Q+       A  +  E Q ++    +
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799

Query: 300  RMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRK---DHKKADVEEEIKIPVVCALTQEE 356
             +E       L   + ++K+  +++ Q + N      D +K   E+E+   ++    +E 
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859

Query: 357  SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGS 416
             S  +  +E H           +    L   D  +K    +        ++T+    S  
Sbjct: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL-------EENTEEKSKSHL 1912

Query: 417  LQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAI 476
            +Q K L  N +A+     ++ +F  L GA+   +      +  LQ     ML K+ ++ +
Sbjct: 1913 VQPKLLS-NMEAQH----NDLEF-KLAGAEREKQKLG-KEIVRLQKDLR-MLRKEHQQEL 1964

Query: 477  KAMTPE-QEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDM 535
            + +  E  +E    +    + +E  + S +  +L+ E    L QKE       +    + 
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNS-TLKQLMREFNTQLAQKE-QELEMTIKETINK 2022

Query: 536  CSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQEL----EDFIKQSSED 591
                E +L  ++  + ET   +KK    + + +D L++T K  +E+    E+ +     D
Sbjct: 2023 AQEVEAEL--LESHQEETNQLLKK----IAEKDDDLKRTAKRYEEILDAREEEMTAKVRD 2076

Query: 592  SSHQISALVLRAQA----------SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEE 641
               Q+  L  + Q             + + ELQ  L+Q    + +      + REQ+   
Sbjct: 2077 LQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL 2136

Query: 642  LVRLQK 647
              RL+K
Sbjct: 2137 EDRLKK 2142



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 119/566 (21%), Positives = 234/566 (41%), Gaps = 82/566 (14%)

Query: 306 TSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEE 365
           TS    Q++E    ++E  + Q   ++   +   VE   + P+  +L +  S   L    
Sbjct: 39  TSSFTEQLDE-GTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRT- 96

Query: 366 EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYN 425
               S+R S++ LD      S DP S  D++          + D +G S SL  + L   
Sbjct: 97  ----SSRESLNRLDLDSSTASFDPPSDMDSE----------AEDLVGNSDSLNKEQLIQR 142

Query: 426 YKAKSAG-NLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQE 484
            +      +     +  LV A  + +       G        +L++ Q+++++ +   +E
Sbjct: 143 LRRMERSLSSYRGKYSELVTAYQMLQREKKKLQG--------ILSQSQDKSLRRIAELRE 194

Query: 485 ETA---SLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN---------KLGRR 532
           E          + +  +++      Y  V +T+ +LL++ + N            +L  +
Sbjct: 195 ELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQ 254

Query: 533 CDMCSNYEK-QLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSED 591
            ++ +  E  +  G  + E  T   VK L+         L++ +K ++ L    K++ + 
Sbjct: 255 AEVFTKEENPESDGEPVVEDGT--SVKTLET--------LQQRVKRQENLLKRCKETIQS 304

Query: 592 SSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDS 651
              Q + L    +A +  L+E  Q L + K     +   L+         + +L++D   
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGM 364

Query: 652 L--QGKHSLHVSLQQAEDFI---------LPDTTEALRELVLKYR----EDIINVRTAAD 696
           +  + K  +H +L+  E+ I         +    E LRE   K      E++    + A 
Sbjct: 365 VIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQ 424

Query: 697 HVEE---KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKV 753
             EE   KLKAE   + EQI+  +   E    +LQ E+   K+E+  +    +E +  K+
Sbjct: 425 KTEEARRKLKAE---MDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481

Query: 754 EKGQATVEQLMFEEKNKAQRLQT-ELDVSEQV-------QRDFVKLSQTLQVQLERIRQA 805
           +K     ++L  +E+   ++LQT E +  EQ+       Q +++K+SQ  + Q     + 
Sbjct: 482 QK--LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539

Query: 806 DSLERIRAIL--NDTKLTDINQLPET 829
             L++ +AIL  ++ KL D+ Q  ET
Sbjct: 540 LELQK-KAILTESENKLRDLQQEAET 564



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 83/371 (22%), Positives = 161/371 (43%), Gaps = 46/371 (12%)

Query: 29   LRAQQQLEQEFN--QKRAKFKELYLA-KEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEM 85
            ++A+Q LE  F+  QK  + KEL     E+ +K  ++ L   ++     R ++ E  ++ 
Sbjct: 1825 IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH---RVEMEELTSKY 1881

Query: 86   ENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQ 145
            E ++A+  +    K     E+  +  EE +    V  + + + E Q H  LE +     +
Sbjct: 1882 EKLQALQQMDGRNKPT---ELLEENTEEKSKSHLVQPKLLSNMEAQ-HNDLEFKLAGAER 1937

Query: 146  YRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEA 205
             ++   +EI  L++ L   ++E   E E+ K + D E+   +    E+E   LK   T  
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKI--KQEQEDLELKHNST-- 1993

Query: 206  EDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHL 265
               +K+L    ++E N  L  ++      E+ + +  T     + +AE L     E   L
Sbjct: 1994 ---LKQL----MREFNTQLAQKEQ-----ELEMTIKETINKAQEVEAELLESHQEETNQL 2041

Query: 266  LEQERQQHNQLKHT---WQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQE 322
            L++  ++ + LK T   +++  D   E     +RD+Q            Q+EEL+KK Q+
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT-----------QLEELQKKYQQ 2090

Query: 323  DDEQQRLNKRKDH-----KKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHS 377
              EQ+  N   D+      +  + ++  +     L ++E   Q+ N E+ L     +V++
Sbjct: 2091 KLEQEE-NPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149

Query: 378  LDAGLLLPSGD 388
               G     G+
Sbjct: 2150 TTVGTPYKGGN 2160


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  105 bits (261), Expect = 2e-22
 Identities = 177/824 (21%), Positives = 340/824 (41%), Gaps = 85/824 (10%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AE  +++ E    Q+QL Q   ++++K++    + E +L   +  + + Q  L     Q 
Sbjct: 1278 AEKSQVHTELQDLQRQLSQN-QEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQR 1336

Query: 79   WEAQAEMENIKAIA---TVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR 135
             EAQ E E ++A     T      Q A+ E + Q     AS   +++E +R       L+
Sbjct: 1337 MEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ-----ASAAGILEEDLRTARSA--LK 1389

Query: 136  LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN--LENEMKKAQEDAEKLRSVVMPMEK 193
            L+ E  +  + R  A +E  +L+    +  +E    L   + + +E+ E LR  +  +EK
Sbjct: 1390 LKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEK 1449

Query: 194  EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
            +         E +    EL +  +K+ N  ++ ++    +LE   +VL      +QE  +
Sbjct: 1450 Q--------REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501

Query: 254  KLRKELHEVCHLLEQERQQHNQLKHTW--QKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
            KL  +  ++  L +    Q N L+H     +  DQ +ESQR  ++D+++  + L    L 
Sbjct: 1502 KLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL- 1560

Query: 312  QVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDST 371
               EL++   + + QQ+L K  + ++   E +        L  EE S +L  +   +   
Sbjct: 1561 ---ELEENHHKMECQQKLIKELEGQR---ETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614

Query: 372  RGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRR----AQSTDSLGTSGSLQSKALGY--N 425
                HS      L   D   KS  +  ++  R+     Q  +       LQ + +    +
Sbjct: 1615 ES--HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672

Query: 426  YKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD----QERAIKAMTP 481
             + +    L+E                D   +       G  LT      QERA +   P
Sbjct: 1673 QRTRQTKILEE----------------DLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716

Query: 482  EQEETASL--LSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNY 539
             + +  SL  +  + +  E        +    +   + L++++     K+G    + S  
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL 599
            E+++  +Q Q  E R+Q +  +  L+   D+ ++ +  + +  + ++Q  + +  Q   +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836

Query: 600  VLRAQASEILLE-----------ELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKD 648
              +A A +  LE           ELQ    QA+R ++E++AV    R Q  EE++   + 
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARR-LEEELAV-EGRRVQALEEVLGDLRA 1894

Query: 649  NDSLQGKHSLHVSLQQAEDFILPDT-TEALR------ELVLKYREDIINVRTA----ADH 697
                Q K  L +  Q AE     +  T AL+      + VLK R+  +    A    + H
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954

Query: 698  VEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQ 757
             EE  +A    L+E +       +  E+ L  + E  +   AS ++L+A L+  +    Q
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014

Query: 758  ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 801
                  + E + + Q L+ + DV +Q+Q+   +  + L+ Q ER
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDV-QQLQQALAQRDEELRHQQER 2057



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 186/835 (22%), Positives = 341/835 (40%), Gaps = 93/835 (11%)

Query: 22   EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
            E++ +E  RAQ  L+++   K A+ K L    +E+L      L   ++++  LR Q+ E 
Sbjct: 1393 EEVESERERAQA-LQEQGELKVAQGKAL----QENLALLTQTLAEREEEVETLRGQIQEL 1447

Query: 82   QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLE-QER 140
            + + E  KA   +       ++D  KR   +EV   Q  ++E  +      HL +  QER
Sbjct: 1448 EKQREMQKAALELL------SLDLKKRN--QEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499

Query: 141  TQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKD 200
             Q    +    RE+   R       E + LE  ++K  +  E  R  V  ++K++  L+ 
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLE--LEKKDQMIESQRGQVQDLKKQLVTLEC 1557

Query: 201  KLTEAEDKIKELEASK--VKELNHYLEAEKSCRT----DLEMYVAVLNTQKSV---LQED 251
               E E+   ++E  +  +KEL    E ++   T    DLE     L  Q S    L+  
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
            +  L +EL E    ++ +R+Q  +L+   +          + LM   +R++ VL  ++ R
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ-VLEDQRTR 1676

Query: 312  QVEELKKKDQEDDEQQRLNKRKDHKKADVE--------EEIKIPVVCAL-TQEESSAQLS 362
            Q + L    +ED EQ +L+ R+  ++   +        EE K P      + E     L 
Sbjct: 1677 QTKIL----EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR 1732

Query: 363  NEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKAL 422
            ++E+ ++  +  +H L             K   +    GL R     SL  S   Q   +
Sbjct: 1733 DKEKEVECQQEHIHELQE----------LKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782

Query: 423  GYNY--KAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  +A+  G L E          S+    D A     Q        + +++  +   
Sbjct: 1783 LQQQLQEAREQGELKEQ---------SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNK-------LGRRC 533
               +E A  L    +          G     + +   L++E+   G +       LG   
Sbjct: 1834 ERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLR 1893

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
                  EK L  +Q Q AE   + +     L+ +  Q +  +K++ +  + ++  S+ S 
Sbjct: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953

Query: 594  HQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSRE---QVSEELVRLQKDND 650
            HQ  A   RA+A       LQ+ L +A   +Q +   L++  E    +      LQ   D
Sbjct: 1954 HQEEAARARAEA-------LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLK--AEILF 708
            + Q  HS     +Q E+ +     E +++  L+Y+ED+  ++ A    +E+L+   E   
Sbjct: 2007 ACQA-HS-----RQLEEALRIQEGE-IQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQ 2059

Query: 709  LKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEK 768
            L E+  A++  +  ++E   L  E  +EEI  +     EL+    +K Q  +E    +++
Sbjct: 2060 LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQR 2119

Query: 769  NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDI 823
            N  + L      S  ++   +KL  +L+ +L+R      LER++A L  T+  +I
Sbjct: 2120 NNLEALPHSHKTS-PMEEQSLKL-DSLEPRLQR-----ELERLQAALRQTEAREI 2167



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 174/850 (20%), Positives = 337/850 (39%), Gaps = 112/850 (13%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A Q   +L +  A LE       R +Q L ++  Q  +  KEL  +   + ++QN+V++ 
Sbjct: 727  AVQEKEALVREKAALEVRLQAVERDRQDLAEQL-QGLSSAKELLESSLFEAQQQNSVIEV 785

Query: 67   AQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVR 126
             +  L      + +A+  ++       +  +T++   ++ +     ++A  +   K  + 
Sbjct: 786  TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845

Query: 127  DYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRS 186
              +      + Q R +W + R   ++E+A    +  E  E E +E EM+  ++  E    
Sbjct: 846  QQKAAHEKEVNQLREKWEKERSWHQQELA----KALESLEREKMELEMRLKEQQTE---- 897

Query: 187  VVMPMEKEIAALKDKLTEAEDKI----KELEASKVKELNHYLEAEK---SCRTDLEMYVA 239
                ME   A  +++ T+AE  +     E E  +V  L   L+ +K        LE    
Sbjct: 898  ----MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ 953

Query: 240  VLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQ 299
             +  QK   QE    L+ +L E    L++  +QH       Q+ +   L+ +     D+Q
Sbjct: 954  DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK----MDLQ 1009

Query: 300  RMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSA 359
                       +QVE+LK +    D+ QRL ++      +V+E+++       TQE +  
Sbjct: 1010 -----------KQVEDLKSQLVAQDDSQRLVEQ------EVQEKLR------ETQEYNRI 1046

Query: 360  QLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQS 419
            Q   E E    T   +      L+L   D   + +    +  ++ AQ         S Q 
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK---ELSAQM 1103

Query: 420  KALGYNYKAKSAGNL-DESDFGPLVGADSVSENFDTASLGSLQMPSG--FMLTKDQERAI 476
            + L    K K A  L  E+     + A  ++E    ASL + +  +    +  +  E  +
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163

Query: 477  KAMTPEQE---------ETASLLSSVTQGMESAYVSP---SGYRLVSETEWNLLQKEVHN 524
            +A+  EQ+         + ASL S++ Q + S   S    SG    + + W L  +   N
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGL--EPDQN 1221

Query: 525  AGNKLGRRCDMCS------------NYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLE 572
                L +R  + +               + L   Q      RDQV+KL+  L     +  
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKS 1281

Query: 573  KTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLM 632
            +   + Q+L+  + Q+ E+ S                 E  Q  L     ++ E MA L 
Sbjct: 1282 QVHTELQDLQRQLSQNQEEKSK---------------WEGKQNSLESELMELHETMASLQ 1326

Query: 633  QSREQVSEELVRLQKDNDSLQ-GKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINV 691
                +   + +  Q + + LQ  K +L   ++  +  ++    +A    +L+  ED+   
Sbjct: 1327 SRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILE--EDLRTA 1384

Query: 692  RTAADHVEEKLKAE---ILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAEL 748
            R+A     E++++E      L+EQ + +    + L+E L L  +   E    + +L+ ++
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444

Query: 749  ERIKV--EKGQATVEQLMFEEKNKAQRLQTELD----------VSEQVQRDFVKLSQTLQ 796
            + ++   E  +A +E L  + K + Q +  + +          V E +     +  Q L 
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504

Query: 797  VQLERIRQAD 806
            VQ E+IR+ +
Sbjct: 1505 VQREQIRELE 1514



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 174/846 (20%), Positives = 349/846 (41%), Gaps = 137/846 (16%)

Query: 2    AQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQN 61
            AQ   A+Q  + L+   ++LE + AE    QQ   Q   Q +A+   LY A ++ L    
Sbjct: 1144 AQEAKAAQLQLRLRSTESQLEALAAE----QQPGNQA--QAQAQLASLYSALQQAL---G 1194

Query: 62   AVLQAAQD--DLGHLRTQLWEAQAEMENIKAI---ATVSENTKQEAIDEVKRQWREEVAS 116
            +V ++  +    G     +W  + +    +++     +      EA+     +  +++  
Sbjct: 1195 SVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWK 1254

Query: 117  LQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKK 176
             Q   ++ +RD       +LE+  T     +     E+ DL+R+LS+ QEE++      K
Sbjct: 1255 TQQT-RDVLRDQVQ----KLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS------K 1303

Query: 177  AQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT---- 232
             +     L S +M + + +A+L+ +L  AE  ++ +EA   +EL   L+A K   T    
Sbjct: 1304 WEGKQNSLESELMELHETMASLQSRLRRAE--LQRMEAQGEREL---LQAAKENLTAQVE 1358

Query: 233  DLEMYVAVLNTQKS---VLQEDAEKLRKELHEVCHLLEQER------QQHNQLKHTWQKA 283
             L+  V     Q S   +L+ED    R  L      +E ER      Q+  +LK    KA
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA 1418

Query: 284  NDQFLE--SQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADV- 340
              + L   +Q L  R+    E+     Q++++E+ ++  +   E   L+ +K +++ D+ 
Sbjct: 1419 LQENLALLTQTLAERE---EEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475

Query: 341  EEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKD 400
            +E+I+    C    E     +   E+ L   R  +  L+            ++  ++ + 
Sbjct: 1476 QEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD---------RETQRNVLEH 1526

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L   +  D                        + ES  G +     + +   T    +L
Sbjct: 1527 QLLELEKKD-----------------------QMIESQRGQV---QDLKKQLVTLECLAL 1560

Query: 461  QMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGME---SAYVSPSGYRLVSETEWNL 517
            ++       + Q++ IK +  ++E     L+ +T  +E       + S      E+   +
Sbjct: 1561 ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620

Query: 518  LQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKD 577
            L +E+     ++  + +     ++Q + +  Q+ E RDQ    +LML++   Q+ +  + 
Sbjct: 1621 LARELQERDQEVKSQREQIEELQRQKEHL-TQDLERRDQ----ELMLQKERIQVLEDQRT 1675

Query: 578  KQE--LEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSR 635
            +Q   LE+ ++Q       +   L  + Q  +   EE  +G S+A+R   E M ++++ +
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE-GKGPSKAQRGSLEHMKLILRDK 1734

Query: 636  EQ----VSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIIN 690
            E+      E +  LQ+  D L Q    LH  + +               L+L  RE    
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET-------------SLLLSQREQ--- 1778

Query: 691  VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELER 750
                          EI+ L++Q+Q  +   E  E++LQ +++  +  +A       ELE 
Sbjct: 1779 --------------EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ---ELEA 1821

Query: 751  IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE- 809
            ++ E+ QA  ++   +E  KA  LQ  L+ +    ++     Q  + Q  R+ +  ++E 
Sbjct: 1822 LQQEQQQAQGQEERVKE--KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879

Query: 810  -RIRAI 814
             R++A+
Sbjct: 1880 RRVQAL 1885



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 178/872 (20%), Positives = 347/872 (39%), Gaps = 132/872 (15%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            ++Q V E  +   E+ R Q++LE+E    +A      + KE+ L          Q +L  
Sbjct: 1029 VEQEVQEKLRETQEYNRIQKELERE----KASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
            LR  + EAQ E + + A            ++ ++++ +E+ A   A   + + + E    
Sbjct: 1085 LRQDMQEAQGEQKELSA-----------QMELLRQEVKEKEADFLAQEAQLLEELEASHI 1133

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEE----ENLENEMKKAQEDAEKLRSVVM 189
               +   + WAQ  ++A+ +   LR R +E Q E    E       +AQ     L S + 
Sbjct: 1134 TEQQLRASLWAQEAKAAQLQ---LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190

Query: 190  PMEKEIAALKDKLTEAEDKIKEL-----------EASKVKELNHYLEAEKSCRTDLEMYV 238
                 +   + +L+   D    +              K   L   L AE       +++ 
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250

Query: 239  AVLNTQKS--VLQEDAEKLRKEL----------HEVCHLLEQERQQHNQLKHTWQKANDQ 286
             +  TQ++  VL++  +KL + L          H     L+++  Q+ + K  W+     
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE----- 1305

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKI 346
                Q  L  ++  +   + S Q R      ++ +   E++ L   K++  A V E ++ 
Sbjct: 1306 --GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQV-EHLQA 1362

Query: 347  PVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQ 406
             VV A  Q  ++  L   EE L + R ++                K  N+  +    RAQ
Sbjct: 1363 AVVEARAQASAAGIL---EEDLRTARSAL----------------KLKNEEVESERERAQ 1403

Query: 407  STDSLGTSGSLQSKALGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSG 465
            +    G     Q KAL  N    +    + E +   L G     E        +L++ S 
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSL 1463

Query: 466  FMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
             +  ++QE  ++    EQ +      SV + +  A         V   +   L+K+    
Sbjct: 1464 DLKKRNQEVDLQ---QEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKK------LQLMLRQANDQLEKTMKDKQ 579
             N L  +       EK+ Q I+ Q  + +D  K+      L L L + + ++E   K  +
Sbjct: 1521 RNVLEHQ---LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577

Query: 580  ELED--------------FIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQ 625
            ELE                +++ S++   Q S +      S +L  ELQ+   Q  +  +
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE-RDQEVKSQR 1636

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYR 685
            EQ+  L + +E ++++L R  +D + +  K  + V L+           E L ++ L  R
Sbjct: 1637 EQIEELQRQKEHLTQDLER--RDQELMLQKERIQV-LEDQRTRQTKILEEDLEQIKLSLR 1693

Query: 686  EDIINVRTAADHVEEK--------------LKAEILFLKEQIQAEQCLKEN------LEE 725
            E    + T    ++E+              L+   L L+++ +  +C +E+      L++
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKD 1753

Query: 726  TLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQ-- 783
             L+ +++    ++   S L ++ E+ ++   Q  +++   + + K Q LQ++LD +++  
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQ-EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL 1812

Query: 784  VQRD-----FVKLSQTLQVQLERIRQ-ADSLE 809
             QRD       +  Q  Q Q ER+++ AD+L+
Sbjct: 1813 AQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 181/919 (19%), Positives = 367/919 (39%), Gaps = 180/919 (19%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV--LQAAQDDL 71
            L+Q    L ++N E    Q Q +    QK  + +EL+LA  E  + Q  +  L+A Q + 
Sbjct: 482  LEQEAWRLRRVNVEL---QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538

Query: 72   -------------GHL--------RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQW 110
                          HL        +T++  A A  E   A  + SENT +  + ++    
Sbjct: 539  LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADL---- 594

Query: 111  REEVASLQAVMKETVRDYE--HQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE 168
            R     L A+ +    D    +Q  L+LE+E        E+AE+    L+  L+E ++  
Sbjct: 595  RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654

Query: 169  --------NLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKEL 220
                    +LE +++KA+E   +L++ +  +++E   ++ KL+E+  + +E   +++++L
Sbjct: 655  EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ-QEAATTQLEQL 713

Query: 221  NHYLEAEKSC-------RTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC---HLLEQ-- 268
            +   + ++         +  L    A L  +   ++ D + L ++L  +     LLE   
Sbjct: 714  HQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773

Query: 269  -ERQQHNQL----KHTWQKANDQFLESQRLLMRDMQRMEIVLTSE-------------QL 310
             E QQ N +    K   +       +++ ++  +++ +++ L +E             QL
Sbjct: 774  FEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL 833

Query: 311  RQVEELKK------KDQEDDEQQRLNKRKDHKKADVEEEI----------KIPVVCALTQ 354
             Q E+  K      K   + E  +L ++ + +++  ++E+          K+ +   L +
Sbjct: 834  AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKE 893

Query: 355  EES---SAQLSNEEE-----------HLDSTRGSVHSLDAGL-----LLPSGDPFSKSDN 395
            +++   + Q   EEE            L++ +  V  L+  L     L  +     +   
Sbjct: 894  QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ 953

Query: 396  DMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTA 455
            DM      + Q      T+G LQ++      + K A      D   L    S        
Sbjct: 954  DM------KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS-------- 999

Query: 456  SLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEW 515
                  +    M  + Q   +K+    Q+++  L+    Q            +L    E+
Sbjct: 1000 -----SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ-----------EKLRETQEY 1043

Query: 516  NLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAET--RDQVKKLQLMLRQANDQLEK 573
            N +QKE+      L       S  EK+ + + +QEA++  + ++  L+  +++A  + ++
Sbjct: 1044 NRIQKELEREKASL-----TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098

Query: 574  TMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ 633
                 + L   +K+   D   Q + L+   +AS I  ++L+  L  A+     Q+ + ++
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL-WAQEAKAAQLQLRLR 1157

Query: 634  SREQVSEELVRLQKDNDSLQGK---HSLHVSLQQAEDFILPDTTEALREL---------V 681
            S E   E L   Q+  +  Q +    SL+ +LQQA    L    E+  EL         V
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQA----LGSVCESRPELSGGGDSAPSV 1213

Query: 682  LKYREDIINVRTAADH-------VEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENC 734
                 D    R+             E + + +  L + +   Q  ++ L + +Q   E  
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273

Query: 735  KEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT 794
             +  A  S +  EL+ ++ +  Q        EEK+K +  Q  L      + + ++L +T
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQ------EEKSKWEGKQNSL------ESELMELHET 1321

Query: 795  LQVQLERIRQADSLERIRA 813
            +     R+R+A+ L+R+ A
Sbjct: 1322 MASLQSRLRRAE-LQRMEA 1339



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 166/797 (20%), Positives = 324/797 (40%), Gaps = 107/797 (13%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE---EDLKRQNAVL 64
            SQ   +   ++ +LE  +    R  Q+ +QE   +R + +EL   KE   +DL+R++  L
Sbjct: 1601 SQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL 1660

Query: 65   QAAQDDLGHLRTQLWE----AQAEMENIKAI-------ATVSENTKQEAIDEVKRQWREE 113
               ++ +  L  Q        + ++E IK          T      QE  +E K   + +
Sbjct: 1661 MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQ 1720

Query: 114  VASLQAVMKETVRDYE-----HQFHL-RLEQERTQWAQYRE--------------SAERE 153
              SL+  MK  +RD E      Q H+  L++ + Q  Q  +                E+E
Sbjct: 1721 RGSLEH-MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQE 1779

Query: 154  IADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEA---EDKIK 210
            I  L+++L E +E+  L+ +  ++Q D  + +  +   ++E+ AL+ +  +A   E+++K
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLD--EAQRALAQRDQELEALQQEQQQAQGQEERVK 1837

Query: 211  E--------LEAS--KVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELH 260
            E        LE +   +KE +  L+  K     LE  +AV   +   L+E    LR E  
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897

Query: 261  E----VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEEL 316
            E    +  L +Q  +Q  + +   +   D +L++Q +L    Q +E +    Q  + +E 
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEE 1957

Query: 317  KKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVH 376
              + + +  Q+ L K     +   E+ +      + + E S+A L   +  LD+ +    
Sbjct: 1958 AARARAEALQEALGKAHAALQGK-EQHLLEQAELSRSLEASTATL---QASLDACQAHSR 2013

Query: 377  SLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDE 436
             L+  L +  G+     D D     LR  +    L  + + + + L +  + +    L E
Sbjct: 2014 QLEEALRIQEGE---IQDQD-----LRYQEDVQQLQQALAQRDEELRHQQERE---QLLE 2062

Query: 437  SDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQG 496
                  V  + + E     +LG  +            R ++ +T  Q+E   L    TQ 
Sbjct: 2063 KSLAQRVQENMIQEK---QNLGQEREEEEIRGLHQSVRELQ-LTLAQKEQEILELRETQQ 2118

Query: 497  MESAYVSPSGYRLVSETEWNL--------LQKEVHNAGNKLGRRCDMCSNYEKQLQGIQI 548
              +    P  ++     E +L        LQ+E+      L +       + ++ Q + +
Sbjct: 2119 RNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLAL 2178

Query: 549  QEAETRDQVKKLQ--LMLRQAN----DQLEKTMKDKQEL-EDFIKQSSEDSSHQISALVL 601
              A+T+  V  LQ   M  QA+    D  ++ ++D+ EL    +++    S    S   L
Sbjct: 2179 SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAEL 2238

Query: 602  RAQASE-ILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKH-SLH 659
             ++  + + L E+    ++   D  E+ +   Q  E + + + RL+ D   LQ  +  L 
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQS-WRQRLEHLQQAVARLEIDRSRLQRHNVQLR 2297

Query: 660  VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE--------------KLKAE 705
             +L+Q E        EA+R       E  I+  TA+   ++              +L+ E
Sbjct: 2298 STLEQVERERRKLKREAMRAAQAGSLE--ISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355

Query: 706  ILFLKEQIQAEQCLKEN 722
            ++ L+ Q+  E+  K++
Sbjct: 2356 VVLLQAQLTLERKQKQD 2372



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 166/832 (19%), Positives = 333/832 (40%), Gaps = 121/832 (14%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L+Q++A  ++      +   Q E+E    R + ++L   + + L  Q   LQ   D L  
Sbjct: 405  LRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL-TGERDTLAGQTVDLQGEVDSLSK 463

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEA--IDEVKRQWREEVASLQAVMKETVRDYEHQ 131
             R  L +A+ E+          E  +QEA  +  V  + + +  S Q   +E     + +
Sbjct: 464  ERELLQKAREELRQ------QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQ----QEE 513

Query: 132  FHLRL-EQERTQ-WAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM 189
             HL + E+ER Q      E+ + E       L E  E  +LE E+ + QE  E + + + 
Sbjct: 514  LHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLR-QEQTE-VTAALA 571

Query: 190  PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
              E+ IA L       + ++ +L A+ VK               L      L   K  L 
Sbjct: 572  RAEQSIAELSSSENTLKTEVADLRAAAVK---------------LSALNEALALDKVGLN 616

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTW---QKANDQFLESQRLLMRDMQRMEIVLT 306
            +   +L +E   VC  +E   Q  N L+      +K  +   E    L   +Q+ E    
Sbjct: 617  QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA 676

Query: 307  SEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
              Q     +L+   +E +E Q+      H++     +++     A  QEE  A+   E+E
Sbjct: 677  ELQA----DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732

Query: 367  HLDSTRGSVH-SLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYN 425
             L   + ++   L A                + +D    A+    L ++  L   +L   
Sbjct: 733  ALVREKAALEVRLQA----------------VERDRQDLAEQLQGLSSAKELLESSL--- 773

Query: 426  YKAKSAGNLDESDFGPL-VGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQE 484
            ++A+   ++ E   G L V   +V++  +    G ++      L  D ER+      EQE
Sbjct: 774  FEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ-GEVRC---LKLELDTERS----QAEQE 825

Query: 485  ETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQ 544
              A+    + Q  +    +    +   E E N L+++                 +EK+  
Sbjct: 826  RDAAA-RQLAQAEQEGKTALEQQKAAHEKEVNQLREK-----------------WEKERS 867

Query: 545  GIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQ-ELEDFIKQSSEDSSHQISALVLRA 603
              Q + A+  + +++ ++       +LE  +K++Q E+E    Q  E+ +   SAL    
Sbjct: 868  WHQQELAKALESLEREKM-------ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920

Query: 604  QASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ 663
              +E     L + L Q ++++ +    L + R+ +  + ++ Q+    LQ        LQ
Sbjct: 921  LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQ------TQLQ 974

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENL 723
            +A+          L+E   ++R+D+  ++  +  + +  K ++    E ++++   +++ 
Sbjct: 975  EAQ--------RELKEAARQHRDDLAALQEESSSLLQD-KMDLQKQVEDLKSQLVAQDDS 1025

Query: 724  EETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ----LMFEEKNKAQRLQTELD 779
            +  ++ E++    E    + ++ ELER K     + +E+    L+ +E +  +  Q EL 
Sbjct: 1026 QRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR--QQELS 1083

Query: 780  VSEQVQRDFVKLSQTLQVQLERIRQ------ADSLERIRAILNDTKLTDINQ 825
               Q  ++     + L  Q+E +RQ      AD L +   +L + + + I +
Sbjct: 1084 ALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 77/390 (19%), Positives = 153/390 (39%), Gaps = 100/390 (25%)

Query: 518 LQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQA---NDQLEKT 574
           L+KE H    +L          + + QG  +++AE +D+V +L  +L Q+   N+  EK 
Sbjct: 256 LEKEAHERSQEL---------IQLKSQG-DLEKAELQDRVTELSALLTQSQKQNEDYEKM 305

Query: 575 MKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQ--------------- 619
           +K  +E  + ++ +  +     ++L   AQ  ++ L+++ + ++Q               
Sbjct: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGH 365

Query: 620 -----------------------------------AKRDVQEQMA-------VLMQSREQ 637
                                              A +D+++Q+A       +L Q  +Q
Sbjct: 366 ENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQ 425

Query: 638 VSEE-------LVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIIN 690
             EE       L +L  + D+L G+    V LQ   D +  +     REL+ K RE++  
Sbjct: 426 WEEEGKALRQRLQKLTGERDTLAGQT---VDLQGEVDSLSKE-----RELLQKAREELRQ 477

Query: 691 VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK--------------E 736
                +    +L+   + L+ Q  + Q  KE  +E L L +   +              E
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE 537

Query: 737 EIASISSLKAELERIKVEKGQATVEQL-MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 795
            ++ + +L+  LE   +E      EQ  +     +A++   EL  SE   +  V   +  
Sbjct: 538 SLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA 597

Query: 796 QVQLERIRQADSLERIRAILNDTKLTDINQ 825
            V+L  + +A +L+++       +L + NQ
Sbjct: 598 AVKLSALNEALALDKVGLNQQLLQLEEENQ 627



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 164/857 (19%), Positives = 330/857 (38%), Gaps = 113/857 (13%)

Query: 15  QQRVAEL-EKINAEFLRAQ---QQLEQEF------------NQKRAKFKELYLAKEEDLK 58
           QQR A L  K+ A+ L+ +   Q+LE+              N +     EL +  EE+ +
Sbjct: 49  QQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQ 108

Query: 59  RQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQ 118
           R  ++ +       H+       +A  E+++ + TV  +  ++ +   + QW+ E    +
Sbjct: 109 RCESLAEVNTQLRLHMEKADVVNKALREDVEKL-TVDWSRARDELMRKESQWQMEQEFFK 167

Query: 119 AVMKETVRDYEHQFHLRLEQE----RTQWAQYRESAEREIADLRR--------------R 160
             +K      EH   L L +E    R  + + + + +R++ +L+               R
Sbjct: 168 GYLKG-----EHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLR 222

Query: 161 LSEG-QEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKE 219
           L+ G Q  E   +     +E A+ L  +    E E         EA ++ +EL      +
Sbjct: 223 LTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELE--------KEAHERSQELI-----Q 269

Query: 220 LNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHT 279
           L    + EK+   D    ++ L TQ     ED EK+ K L E   +LE    +  + + +
Sbjct: 270 LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS 329

Query: 280 WQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKAD 339
             +   +   S + +++D+ ++ +    E+   + +    +   +    +  + D++ AD
Sbjct: 330 LSRNAQEEKLSLQQVIKDITQVMV----EEGDNIAQGSGHENSLELDSSIFSQFDYQDAD 385

Query: 340 VEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFK 399
               +   V   LT+   + Q  +  + L   + +V+     LL    D + +    + +
Sbjct: 386 KALTL---VRSVLTRRRQAVQ--DLRQQLAGCQEAVN-----LLQQQHDQWEEEGKALRQ 435

Query: 400 DGLRRAQSTDSL-GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLG 458
              +     D+L G +  LQ +    + + +      E     L   +  +      ++ 
Sbjct: 436 RLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE 495

Query: 459 -SLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET---E 514
             LQ  S     ++Q+  +     E+E    +L  +      +       R   E+   E
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE 555

Query: 515 WNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKT 574
             LL++E       L R     +        ++ + A+ R    KL  +        E  
Sbjct: 556 GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-------NEAL 608

Query: 575 MKDKQELEDFIKQSSEDSSHQISALVLRAQASEIL------LEELQQGLSQAKRDVQEQM 628
             DK  L   + Q  E++    S +    QA   L       E+ ++ L +    ++ Q+
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668

Query: 629 AVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL--VLKYRE 686
               ++  ++  +L  +Q++ + +Q K S     Q+A        T  L +L    K +E
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA-------ATTQLEQLHQEAKRQE 721

Query: 687 DIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI-ASISSLK 745
           +++     A   +E L  E   L+ ++QA +  +++L E LQ  + + KE + +S+   +
Sbjct: 722 EVL---ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQ-GLSSAKELLESSLFEAQ 777

Query: 746 AELERIKVEKGQATVE-QLMFEEKNKAQ--------RLQTELDVSEQ----VQRDFVKLS 792
            +   I+V KGQ  V+ Q + + K   Q         L TE   +EQ      R   +  
Sbjct: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE 837

Query: 793 QTLQVQLERIRQADSLE 809
           Q  +  LE+ + A   E
Sbjct: 838 QEGKTALEQQKAAHEKE 854


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  102 bits (253), Expect = 2e-21
 Identities = 181/872 (20%), Positives = 370/872 (42%), Gaps = 99/872 (11%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1194 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1304

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1305 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1360

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1481 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG------IQIQEA-----ETRDQVKKLQLMLRQAND 569
                +L    ++  + +  +K+L+G      +Q   A     E   Q++KLQ  ++    
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
            +LE     + E+    K++ E  +  + A +++ Q      E  ++     K ++ E++A
Sbjct: 1660 ELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 630  VLMQSREQVSEE-------LVRLQKDNDSLQGKHS-----LHVSLQQAEDFILPDTTEAL 677
              +  R  + +E       + +L+++ +  QG        +  + QQAE       TE  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 678  ----------------RELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE 721
                            +EL  K  E    V++        L+A+I  L+EQ++ E   K+
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 722  NLEETLQLEIENCKEEIASISSLKAELERIK--VEKGQATVEQL---MFEEKNKAQR--- 773
               ++L+ + +  KE +  +   +   E+ K   EKG A V+QL   + E + ++QR   
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 774  ----LQTELDVSEQVQRDFVKLSQTLQVQLER 801
                LQ ELD + +      +    L+ +L R
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 169/792 (21%), Positives = 330/792 (41%), Gaps = 103/792 (13%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1085

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1132

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1133 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1184

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1229

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSS---EDSSHQISALVLRAQASEILLEELQQGLS 618
                   DQL++ M+ KQ LE  I   +    DS  ++       +A E   +  Q+ + 
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 619  QAKRDVQEQMAV---LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTE 675
               +  +E+ A    L +++ ++ +EL  L  D D+ +   S     Q+  D +L +   
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE-- 1460

Query: 676  ALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK 735
              + +  KY ++       A   E K  +    L+E ++A    KE LE T ++     K
Sbjct: 1461 --KNISSKYADERDRAEAEAREKETKALSLARALEEALEA----KEELERTNKM----LK 1510

Query: 736  EEIASISSLKAELER--IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQ 793
             E+  + S K ++ +   ++EK +  +E  M E K + + L+ EL  +E  +       Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 794  TLQVQLERIRQA 805
             L+ Q ER  QA
Sbjct: 1571 ALKGQFERDLQA 1582



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 182/852 (21%), Positives = 354/852 (41%), Gaps = 131/852 (15%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 999  KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1049

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1100

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1101 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1148

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1329 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1378

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1434

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1554 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1599

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1652

Query: 740  SISSLKAELERIKVEKGQ--ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT-LQ 796
             +   + ELE  +  + +  AT +    E + KA+ L+ +L    Q+Q D     +   Q
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAK----ENEKKAKSLEADL---MQLQEDLAAAERARKQ 1705

Query: 797  VQLERIRQADSL 808
              LE+   A+ L
Sbjct: 1706 ADLEKEELAEEL 1717



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 162/801 (20%), Positives = 348/801 (43%), Gaps = 103/801 (12%)

Query: 50   YLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKR- 108
            +L +E DLK  + ++       G+L  + +  +   + + A+  +  N    A  +++  
Sbjct: 777  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKR--QQQLTAMKVIQRNCA--AYLKLRNW 832

Query: 109  QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE 168
            QW      ++ +++ T ++ E Q     E E  +  + ++ AE E+ +L ++ S+  EE+
Sbjct: 833  QWWRLFTKVKPLLQVTRQEEEMQAK---EDELQKTKERQQKAENELKELEQKHSQLTEEK 889

Query: 169  NLENEMKKAQED----AEKLRSVVMPMEKEIAAL----KDKLTEAEDKIKELEASKVK-- 218
            NL  E  +A+ +    AE++R  +   ++E+  +    + +L E ED+ ++L+A + K  
Sbjct: 890  NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949

Query: 219  ----ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHN 274
                +L   LE E++ R  L++        + V  E   K++K   E+  + +Q  +   
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQL--------EKVTAE--AKIKKLEDEILVMDDQNNKLSK 999

Query: 275  QLKHTWQKAND------QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQR 328
            + K   ++ +D      +  E  + L +   + E +++  ++R    LKK+++   E ++
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEK 1055

Query: 329  LNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
            L ++ +   +D  E+I           E   QL+ +EE L +            L    D
Sbjct: 1056 LKRKLEGDASDFHEQI---ADLQAQIAELKMQLAKKEEELQAA-----------LARLDD 1101

Query: 389  PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA--- 445
              ++ +N + K  +R  +     G    LQ   L     A++     + D G  + A   
Sbjct: 1102 EIAQKNNALKK--IRELE-----GHISDLQED-LDSERAARNKAEKQKRDLGEELEALKT 1153

Query: 446  ---DSVSENFDTASLGSLQMPSGFMLTK---DQERAIKAMTPE-QEETASLLSSVTQGME 498
               D++        L + +     +L K   ++ R+ +A   E +++ A  +  +T+ +E
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213

Query: 499  SAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVK 558
                + +      +T    L+KE  +   +L            ++ G   QE E +   K
Sbjct: 1214 QFKRAKANLDKNKQT----LEKENADLAGEL------------RVLGQAKQEVEHKK--K 1255

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            KL+  +++   +     + + EL D + +  ++    ++ ++  A+   I L +    LS
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKL-QNEVESVTGMLNEAEGKAIKLAKDVASLS 1314

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
               +D QE +    + +  VS +L +L+++ +SLQ +    +  +Q  +  +      L 
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCK 735
            +   K  +D  +   A +  +++ + EI  L +Q + +    + LE+T   LQ E+++  
Sbjct: 1375 DSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433

Query: 736  EEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 795
             ++ +   L + LE     K Q   +QL+ EEKN + +   E D +E   R+    + +L
Sbjct: 1434 VDLDNQRQLVSNLE-----KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488

Query: 796  QVQLERIRQA-DSLERIRAIL 815
               LE   +A + LER   +L
Sbjct: 1489 ARALEEALEAKEELERTNKML 1509



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 159/818 (19%), Positives = 330/818 (40%), Gaps = 113/818 (13%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLA---KEEDLKRQNAVLQAAQDDLGHLRT 76
            ELEK+  +         ++    +A+  EL +    KEE+L+   A L        +   
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111

Query: 77   QLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRL 136
            ++ E +  + +++     SE   +   ++ KR   EE+ +L+  +++T+     Q  LR 
Sbjct: 1112 KIRELEGHISDLQEDLD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170

Query: 137  EQERTQWA------QYRESAEREIADLRRRLSEGQEE--ENLENEMKKAQEDAEKLRSVV 188
            ++E+          +   S E ++ ++R++ ++  EE  E LE + K+A+ + +K +   
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQT- 1228

Query: 189  MPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVL 248
              +EKE A L  +L       +E+E  K K      E +  C +D E   A LN      
Sbjct: 1229 --LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARAELN------ 1279

Query: 249  QEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSE 308
             +   KL+ E+  V  +L +   +  +L       + Q  ++Q LL  + ++   V T  
Sbjct: 1280 -DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1336

Query: 309  QLRQVEELKK--KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
            +LRQ+EE +   +DQ D+E +         K ++E  I             + QLS+ ++
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEA--------KQNLERHIST----------LNIQLSDSKK 1378

Query: 367  HLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG-TSGSLQSK----A 421
             L     +V +L+ G        F K   ++ +    +A + D L  T   LQ +     
Sbjct: 1379 KLQDFASTVEALEEGK-----KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433

Query: 422  LGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTP 481
            +  + + +   NL++               FD        + S +    +++RA      
Sbjct: 1434 VDLDNQRQLVSNLEKKQ-----------RKFDQLLAEEKNISSKY--ADERDRAEAEARE 1480

Query: 482  EQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ------KEVHNAGNKLGRRCDM 535
            ++ +  SL  ++ + +E+        +++     +L+       K VH            
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 536  CSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQ 595
                + QL+ ++ +   T D   +L++ ++    Q E+ ++ + E  +  ++  +   H+
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGK 655
                +   +    L    ++ L    +D++ Q    ++ RE+  ++L +LQ      Q  
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-- 1658

Query: 656  HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQA 715
                   ++ ED                 R++I       +   + L+A+++ L+E + A
Sbjct: 1659 -------RELED-------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAEL--ERIKVEKGQATVEQLMFEEK----- 768
                 E   +   LE E   EE+AS  S +  L  E+ ++E   A +E+ + EE+     
Sbjct: 1699 ----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 769  -----NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 801
                  KA +   +L      +R   + +++ + QLER
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 81/364 (22%), Positives = 149/364 (40%), Gaps = 69/364 (18%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1697 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1749

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1750 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1790

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1791 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1843

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1877

Query: 312  QVEELKKKDQE-DDEQQRLN--KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHL 368
            +V++LK++ +E ++E QR+N  +RK  ++ D   E    +   +   +S  +  NE   +
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1937

Query: 369  DSTR 372
             S R
Sbjct: 1938 PSRR 1941



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  102 bits (253), Expect = 2e-21
 Identities = 181/872 (20%), Positives = 370/872 (42%), Gaps = 99/872 (11%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1201 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1311

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1312 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1367

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1488 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG------IQIQEA-----ETRDQVKKLQLMLRQAND 569
                +L    ++  + +  +K+L+G      +Q   A     E   Q++KLQ  ++    
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
            +LE     + E+    K++ E  +  + A +++ Q      E  ++     K ++ E++A
Sbjct: 1667 ELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 630  VLMQSREQVSEE-------LVRLQKDNDSLQGKHS-----LHVSLQQAEDFILPDTTEAL 677
              +  R  + +E       + +L+++ +  QG        +  + QQAE       TE  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 678  ----------------RELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE 721
                            +EL  K  E    V++        L+A+I  L+EQ++ E   K+
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 722  NLEETLQLEIENCKEEIASISSLKAELERIK--VEKGQATVEQL---MFEEKNKAQR--- 773
               ++L+ + +  KE +  +   +   E+ K   EKG A V+QL   + E + ++QR   
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 774  ----LQTELDVSEQVQRDFVKLSQTLQVQLER 801
                LQ ELD + +      +    L+ +L R
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 169/792 (21%), Positives = 330/792 (41%), Gaps = 103/792 (13%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1092

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1139

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1140 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1191

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1236

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSS---EDSSHQISALVLRAQASEILLEELQQGLS 618
                   DQL++ M+ KQ LE  I   +    DS  ++       +A E   +  Q+ + 
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 619  QAKRDVQEQMAV---LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTE 675
               +  +E+ A    L +++ ++ +EL  L  D D+ +   S     Q+  D +L +   
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE-- 1467

Query: 676  ALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK 735
              + +  KY ++       A   E K  +    L+E ++A    KE LE T ++     K
Sbjct: 1468 --KNISSKYADERDRAEAEAREKETKALSLARALEEALEA----KEELERTNKM----LK 1517

Query: 736  EEIASISSLKAELER--IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQ 793
             E+  + S K ++ +   ++EK +  +E  M E K + + L+ EL  +E  +       Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 794  TLQVQLERIRQA 805
             L+ Q ER  QA
Sbjct: 1578 ALKGQFERDLQA 1589



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 182/852 (21%), Positives = 354/852 (41%), Gaps = 131/852 (15%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 1006 KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1056

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1107

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1108 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1155

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1336 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1385

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1441

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1561 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1606

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1659

Query: 740  SISSLKAELERIKVEKGQ--ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT-LQ 796
             +   + ELE  +  + +  AT +    E + KA+ L+ +L    Q+Q D     +   Q
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAK----ENEKKAKSLEADL---MQLQEDLAAAERARKQ 1712

Query: 797  VQLERIRQADSL 808
              LE+   A+ L
Sbjct: 1713 ADLEKEELAEEL 1724



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 162/801 (20%), Positives = 348/801 (43%), Gaps = 103/801 (12%)

Query: 50   YLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKR- 108
            +L +E DLK  + ++       G+L  + +  +   + + A+  +  N    A  +++  
Sbjct: 784  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKR--QQQLTAMKVIQRNCA--AYLKLRNW 839

Query: 109  QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE 168
            QW      ++ +++ T ++ E Q     E E  +  + ++ AE E+ +L ++ S+  EE+
Sbjct: 840  QWWRLFTKVKPLLQVTRQEEEMQAK---EDELQKTKERQQKAENELKELEQKHSQLTEEK 896

Query: 169  NLENEMKKAQED----AEKLRSVVMPMEKEIAAL----KDKLTEAEDKIKELEASKVK-- 218
            NL  E  +A+ +    AE++R  +   ++E+  +    + +L E ED+ ++L+A + K  
Sbjct: 897  NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956

Query: 219  ----ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHN 274
                +L   LE E++ R  L++        + V  E   K++K   E+  + +Q  +   
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQL--------EKVTAE--AKIKKLEDEILVMDDQNNKLSK 1006

Query: 275  QLKHTWQKAND------QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQR 328
            + K   ++ +D      +  E  + L +   + E +++  ++R    LKK+++   E ++
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEK 1062

Query: 329  LNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
            L ++ +   +D  E+I           E   QL+ +EE L +            L    D
Sbjct: 1063 LKRKLEGDASDFHEQI---ADLQAQIAELKMQLAKKEEELQAA-----------LARLDD 1108

Query: 389  PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA--- 445
              ++ +N + K  +R  +     G    LQ   L     A++     + D G  + A   
Sbjct: 1109 EIAQKNNALKK--IRELE-----GHISDLQED-LDSERAARNKAEKQKRDLGEELEALKT 1160

Query: 446  ---DSVSENFDTASLGSLQMPSGFMLTK---DQERAIKAMTPE-QEETASLLSSVTQGME 498
               D++        L + +     +L K   ++ R+ +A   E +++ A  +  +T+ +E
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220

Query: 499  SAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVK 558
                + +      +T    L+KE  +   +L            ++ G   QE E +   K
Sbjct: 1221 QFKRAKANLDKNKQT----LEKENADLAGEL------------RVLGQAKQEVEHKK--K 1262

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            KL+  +++   +     + + EL D + +  ++    ++ ++  A+   I L +    LS
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKL-QNEVESVTGMLNEAEGKAIKLAKDVASLS 1321

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
               +D QE +    + +  VS +L +L+++ +SLQ +    +  +Q  +  +      L 
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCK 735
            +   K  +D  +   A +  +++ + EI  L +Q + +    + LE+T   LQ E+++  
Sbjct: 1382 DSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440

Query: 736  EEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 795
             ++ +   L + LE     K Q   +QL+ EEKN + +   E D +E   R+    + +L
Sbjct: 1441 VDLDNQRQLVSNLE-----KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495

Query: 796  QVQLERIRQA-DSLERIRAIL 815
               LE   +A + LER   +L
Sbjct: 1496 ARALEEALEAKEELERTNKML 1516



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 159/818 (19%), Positives = 330/818 (40%), Gaps = 113/818 (13%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLA---KEEDLKRQNAVLQAAQDDLGHLRT 76
            ELEK+  +         ++    +A+  EL +    KEE+L+   A L        +   
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118

Query: 77   QLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRL 136
            ++ E +  + +++     SE   +   ++ KR   EE+ +L+  +++T+     Q  LR 
Sbjct: 1119 KIRELEGHISDLQEDLD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177

Query: 137  EQERTQWA------QYRESAEREIADLRRRLSEGQEE--ENLENEMKKAQEDAEKLRSVV 188
            ++E+          +   S E ++ ++R++ ++  EE  E LE + K+A+ + +K +   
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQT- 1235

Query: 189  MPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVL 248
              +EKE A L  +L       +E+E  K K      E +  C +D E   A LN      
Sbjct: 1236 --LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARAELN------ 1286

Query: 249  QEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSE 308
             +   KL+ E+  V  +L +   +  +L       + Q  ++Q LL  + ++   V T  
Sbjct: 1287 -DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1343

Query: 309  QLRQVEELKK--KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
            +LRQ+EE +   +DQ D+E +         K ++E  I             + QLS+ ++
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEA--------KQNLERHIST----------LNIQLSDSKK 1385

Query: 367  HLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG-TSGSLQSK----A 421
             L     +V +L+ G        F K   ++ +    +A + D L  T   LQ +     
Sbjct: 1386 KLQDFASTVEALEEGK-----KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440

Query: 422  LGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTP 481
            +  + + +   NL++               FD        + S +    +++RA      
Sbjct: 1441 VDLDNQRQLVSNLEKKQ-----------RKFDQLLAEEKNISSKY--ADERDRAEAEARE 1487

Query: 482  EQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ------KEVHNAGNKLGRRCDM 535
            ++ +  SL  ++ + +E+        +++     +L+       K VH            
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 536  CSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQ 595
                + QL+ ++ +   T D   +L++ ++    Q E+ ++ + E  +  ++  +   H+
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGK 655
                +   +    L    ++ L    +D++ Q    ++ RE+  ++L +LQ      Q  
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-- 1665

Query: 656  HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQA 715
                   ++ ED                 R++I       +   + L+A+++ L+E + A
Sbjct: 1666 -------RELED-------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAEL--ERIKVEKGQATVEQLMFEEK----- 768
                 E   +   LE E   EE+AS  S +  L  E+ ++E   A +E+ + EE+     
Sbjct: 1706 ----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 769  -----NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 801
                  KA +   +L      +R   + +++ + QLER
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 81/364 (22%), Positives = 149/364 (40%), Gaps = 69/364 (18%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1704 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1756

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1757 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1797

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1798 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1850

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1884

Query: 312  QVEELKKKDQE-DDEQQRLN--KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHL 368
            +V++LK++ +E ++E QR+N  +RK  ++ D   E    +   +   +S  +  NE   +
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1944

Query: 369  DSTR 372
             S R
Sbjct: 1945 PSRR 1948



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  100 bits (250), Expect = 4e-21
 Identities = 178/850 (20%), Positives = 362/850 (42%), Gaps = 99/850 (11%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1201 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1311

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1312 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1367

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1488 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG------IQIQEA-----ETRDQVKKLQLMLRQAND 569
                +L    ++  + +  +K+L+G      +Q   A     E   Q++KLQ  ++    
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
            +LE     + E+    K++ E  +  + A +++ Q      E  ++     K ++ E++A
Sbjct: 1667 ELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 630  VLMQSREQVSEE-------LVRLQKDNDSLQGKHS-----LHVSLQQAEDFILPDTTEAL 677
              +  R  + +E       + +L+++ +  QG        +  + QQAE       TE  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 678  ----------------RELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE 721
                            +EL  K  E    V++        L+A+I  L+EQ++ E   K+
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 722  NLEETLQLEIENCKEEIASISSLKAELERIK--VEKGQATVEQL---MFEEKNKAQR--- 773
               ++L+ + +  KE +  +   +   E+ K   EKG A V+QL   + E + ++QR   
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 774  ----LQTELD 779
                LQ ELD
Sbjct: 1906 NRRKLQRELD 1915



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 169/792 (21%), Positives = 330/792 (41%), Gaps = 103/792 (13%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 976  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1092

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1139

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1140 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1191

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1236

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1349

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSS---EDSSHQISALVLRAQASEILLEELQQGLS 618
                   DQL++ M+ KQ LE  I   +    DS  ++       +A E   +  Q+ + 
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409

Query: 619  QAKRDVQEQMAV---LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTE 675
               +  +E+ A    L +++ ++ +EL  L  D D+ +   S     Q+  D +L +   
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE-- 1467

Query: 676  ALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK 735
              + +  KY ++       A   E K  +    L+E ++A    KE LE T ++     K
Sbjct: 1468 --KNISSKYADERDRAEAEAREKETKALSLARALEEALEA----KEELERTNKM----LK 1517

Query: 736  EEIASISSLKAELER--IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQ 793
             E+  + S K ++ +   ++EK +  +E  M E K + + L+ EL  +E  +       Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 794  TLQVQLERIRQA 805
             L+ Q ER  QA
Sbjct: 1578 ALKGQFERDLQA 1589



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 182/852 (21%), Positives = 354/852 (41%), Gaps = 131/852 (15%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 1006 KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1056

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1107

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1108 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1155

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1216 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1275

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1276 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1336 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1385

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1441

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1561 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1606

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1659

Query: 740  SISSLKAELERIKVEKGQ--ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT-LQ 796
             +   + ELE  +  + +  AT +    E + KA+ L+ +L    Q+Q D     +   Q
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAK----ENEKKAKSLEADL---MQLQEDLAAAERARKQ 1712

Query: 797  VQLERIRQADSL 808
              LE+   A+ L
Sbjct: 1713 ADLEKEELAEEL 1724



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 162/801 (20%), Positives = 348/801 (43%), Gaps = 103/801 (12%)

Query: 50   YLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKR- 108
            +L +E DLK  + ++       G+L  + +  +   + + A+  +  N    A  +++  
Sbjct: 784  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKR--QQQLTAMKVIQRNCA--AYLKLRNW 839

Query: 109  QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE 168
            QW      ++ +++ T ++ E Q     E E  +  + ++ AE E+ +L ++ S+  EE+
Sbjct: 840  QWWRLFTKVKPLLQVTRQEEEMQAK---EDELQKTKERQQKAENELKELEQKHSQLTEEK 896

Query: 169  NLENEMKKAQED----AEKLRSVVMPMEKEIAAL----KDKLTEAEDKIKELEASKVK-- 218
            NL  E  +A+ +    AE++R  +   ++E+  +    + +L E ED+ ++L+A + K  
Sbjct: 897  NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956

Query: 219  ----ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHN 274
                +L   LE E++ R  L++        + V  E   K++K   E+  + +Q  +   
Sbjct: 957  QQMLDLEEQLEEEEAARQKLQL--------EKVTAE--AKIKKLEDEILVMDDQNNKLSK 1006

Query: 275  QLKHTWQKAND------QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQR 328
            + K   ++ +D      +  E  + L +   + E +++  ++R    LKK+++   E ++
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEK 1062

Query: 329  LNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
            L ++ +   +D  E+I           E   QL+ +EE L +            L    D
Sbjct: 1063 LKRKLEGDASDFHEQI---ADLQAQIAELKMQLAKKEEELQAA-----------LARLDD 1108

Query: 389  PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA--- 445
              ++ +N + K  +R  +     G    LQ   L     A++     + D G  + A   
Sbjct: 1109 EIAQKNNALKK--IRELE-----GHISDLQED-LDSERAARNKAEKQKRDLGEELEALKT 1160

Query: 446  ---DSVSENFDTASLGSLQMPSGFMLTK---DQERAIKAMTPE-QEETASLLSSVTQGME 498
               D++        L + +     +L K   ++ R+ +A   E +++ A  +  +T+ +E
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220

Query: 499  SAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVK 558
                + +      +T    L+KE  +   +L            ++ G   QE E +   K
Sbjct: 1221 QFKRAKANLDKNKQT----LEKENADLAGEL------------RVLGQAKQEVEHKK--K 1262

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            KL+  +++   +     + + EL D + +  ++    ++ ++  A+   I L +    LS
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKL-QNEVESVTGMLNEAEGKAIKLAKDVASLS 1321

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
               +D QE +    + +  VS +L +L+++ +SLQ +    +  +Q  +  +      L 
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCK 735
            +   K  +D  +   A +  +++ + EI  L +Q + +    + LE+T   LQ E+++  
Sbjct: 1382 DSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440

Query: 736  EEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 795
             ++ +   L + LE     K Q   +QL+ EEKN + +   E D +E   R+    + +L
Sbjct: 1441 VDLDNQRQLVSNLE-----KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1495

Query: 796  QVQLERIRQA-DSLERIRAIL 815
               LE   +A + LER   +L
Sbjct: 1496 ARALEEALEAKEELERTNKML 1516



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 159/818 (19%), Positives = 330/818 (40%), Gaps = 113/818 (13%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLA---KEEDLKRQNAVLQAAQDDLGHLRT 76
            ELEK+  +         ++    +A+  EL +    KEE+L+   A L        +   
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118

Query: 77   QLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRL 136
            ++ E +  + +++     SE   +   ++ KR   EE+ +L+  +++T+     Q  LR 
Sbjct: 1119 KIRELEGHISDLQEDLD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177

Query: 137  EQERTQWA------QYRESAEREIADLRRRLSEGQEE--ENLENEMKKAQEDAEKLRSVV 188
            ++E+          +   S E ++ ++R++ ++  EE  E LE + K+A+ + +K +   
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQT- 1235

Query: 189  MPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVL 248
              +EKE A L  +L       +E+E  K K      E +  C +D E   A LN      
Sbjct: 1236 --LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARAELN------ 1286

Query: 249  QEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSE 308
             +   KL+ E+  V  +L +   +  +L       + Q  ++Q LL  + ++   V T  
Sbjct: 1287 -DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1343

Query: 309  QLRQVEELKK--KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
            +LRQ+EE +   +DQ D+E +         K ++E  I             + QLS+ ++
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEA--------KQNLERHIST----------LNIQLSDSKK 1385

Query: 367  HLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG-TSGSLQSK----A 421
             L     +V +L+ G        F K   ++ +    +A + D L  T   LQ +     
Sbjct: 1386 KLQDFASTVEALEEGK-----KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440

Query: 422  LGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTP 481
            +  + + +   NL++               FD        + S +    +++RA      
Sbjct: 1441 VDLDNQRQLVSNLEKKQ-----------RKFDQLLAEEKNISSKY--ADERDRAEAEARE 1487

Query: 482  EQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ------KEVHNAGNKLGRRCDM 535
            ++ +  SL  ++ + +E+        +++     +L+       K VH            
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 536  CSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQ 595
                + QL+ ++ +   T D   +L++ ++    Q E+ ++ + E  +  ++  +   H+
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGK 655
                +   +    L    ++ L    +D++ Q    ++ RE+  ++L +LQ      Q  
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-- 1665

Query: 656  HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQA 715
                   ++ ED                 R++I       +   + L+A+++ L+E + A
Sbjct: 1666 -------RELED-------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAEL--ERIKVEKGQATVEQLMFEEK----- 768
                 E   +   LE E   EE+AS  S +  L  E+ ++E   A +E+ + EE+     
Sbjct: 1706 ----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 769  -----NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 801
                  KA +   +L      +R   + +++ + QLER
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 72/332 (21%), Positives = 138/332 (41%), Gaps = 67/332 (20%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1704 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1756

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1757 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1797

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1798 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1850

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1884

Query: 312  QVEELKKK-DQEDDEQQRLNKRKDHKKADVEE 342
            +V++LK++ ++ ++E QR+N  +   + +++E
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  100 bits (250), Expect = 4e-21
 Identities = 178/850 (20%), Positives = 362/850 (42%), Gaps = 99/850 (11%)

Query: 14   LQQRVAELE----KINAEFLRAQQQLEQEFNQKRAKFKELYLAK------EEDLKRQNAV 63
            LQ ++AEL+    K   E   A  +L+ E  QK    K++   +      +EDL  + A 
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133

Query: 64   LQAAQD---DLGH----LRTQL---WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE 113
               A+    DLG     L+T+L    ++ A  + ++A         ++A+DE  R    +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSE-GQEEENLEN 172
            V  ++    + V +   Q   + ++ +    + +++ E+E ADL   L   GQ ++ +E+
Sbjct: 1194 VQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252

Query: 173  EMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRT 232
            + KK +   ++L+S     E+  A L DK+ + +++++ +       LN   EAE     
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM----LN---EAEGKA-I 1304

Query: 233  DLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQR 292
             L   VA L++Q   LQ+  E L++E  +  ++  + RQ   + +++ Q   D+ +E+++
Sbjct: 1305 KLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQ 1360

Query: 293  LLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCAL 352
             L R +  + I L+  + +  +     +  ++ ++R  K  ++     EE+         
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAG------LLLPSGDPFSK-SDNDMFKDGLRRA 405
            T+     +L +    LD+ R  V +L+        LL    +  SK +D     +   R 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA-DSVSENFDTASLGSLQMPS 464
            + T +L  + +L+ +AL    + +    + +++   LV + D V +N          + +
Sbjct: 1481 KETKALSLARALE-EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 465  GFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYR-LVSETEWNLLQKEVH 523
                 K Q   ++      E+    L    Q ++  +      R   +E +   LQ+++H
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599

Query: 524  NAGNKLG---RRCDMCSNYEKQLQG------IQIQEA-----ETRDQVKKLQLMLRQAND 569
                +L    ++  + +  +K+L+G      +Q   A     E   Q++KLQ  ++    
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
            +LE     + E+    K++ E  +  + A +++ Q      E  ++     K ++ E++A
Sbjct: 1660 ELEDARASRDEIFATAKEN-EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 630  VLMQSREQVSEE-------LVRLQKDNDSLQGKHS-----LHVSLQQAEDFILPDTTEAL 677
              +  R  + +E       + +L+++ +  QG        +  + QQAE       TE  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 678  ----------------RELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE 721
                            +EL  K  E    V++        L+A+I  L+EQ++ E   K+
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 722  NLEETLQLEIENCKEEIASISSLKAELERIK--VEKGQATVEQL---MFEEKNKAQR--- 773
               ++L+ + +  KE +  +   +   E+ K   EKG A V+QL   + E + ++QR   
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 774  ----LQTELD 779
                LQ ELD
Sbjct: 1899 NRRKLQRELD 1908



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 169/792 (21%), Positives = 330/792 (41%), Gaps = 103/792 (13%)

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIK---AIATVSENTKQEAIDEVKRQWRE--E 113
            RQ   +QA +D+L   + +  +A+ E++ ++   +  T  +N  QE +      + E  E
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 114  VASLQAVMKETVRDYEHQFHLRLEQERTQWAQY---RESAEREIADLRRRLSEGQE-EEN 169
            +    A  K+ + +  H+   RLE+E  +  Q    R+   +++ DL  +L E +   + 
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 170  LENEMKKAQEDAEKLRSVVMPM--------------EKEIAALKDKLTEAEDKIKEL--- 212
            L+ E   A+   +KL   ++ M              E+ I+ L   L E E+K K L   
Sbjct: 969  LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028

Query: 213  ---EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                 S + EL   L+ E+  R +LE     L    S   E    L+ ++ E   L  Q 
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQL 1085

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
             ++  +L+    + +D+  +    L             +++R++E      QED + +R 
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNAL-------------KKIRELEGHISDLQEDLDSERA 1132

Query: 330  NKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
             + K  K K D+ EE++       T+ E +   +  ++ L + R      +  +L  + D
Sbjct: 1133 ARNKAEKQKRDLGEELE----ALKTELEDTLDSTATQQELRAKR----EQEVTVLKKALD 1184

Query: 389  PFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADS 447
              ++S     ++   + AQ+ + L       ++ L    +AK+  NLD++          
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEEL-------TEQLEQFKRAKA--NLDKNK------QTL 1229

Query: 448  VSENFDTAS----LGSLQMPSGFMLTK--DQERAIKAMTPEQEETASLLSSVTQGMESAY 501
              EN D A     LG  +        K   Q + +++   + E   + L+     +++  
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 502  VSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQ 561
             S +G    +E +   L K+V +  ++L        + ++ LQ    Q+     ++++L+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQL-------QDTQELLQEETRQKLNVSTKLRQLE 1342

Query: 562  LMLRQANDQLEKTMKDKQELEDFIKQSS---EDSSHQISALVLRAQASEILLEELQQGLS 618
                   DQL++ M+ KQ LE  I   +    DS  ++       +A E   +  Q+ + 
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402

Query: 619  QAKRDVQEQMAV---LMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTE 675
               +  +E+ A    L +++ ++ +EL  L  D D+ +   S     Q+  D +L +   
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE-- 1460

Query: 676  ALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCK 735
              + +  KY ++       A   E K  +    L+E ++A    KE LE T ++     K
Sbjct: 1461 --KNISSKYADERDRAEAEAREKETKALSLARALEEALEA----KEELERTNKM----LK 1510

Query: 736  EEIASISSLKAELER--IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQ 793
             E+  + S K ++ +   ++EK +  +E  M E K + + L+ EL  +E  +       Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 794  TLQVQLERIRQA 805
             L+ Q ER  QA
Sbjct: 1571 ALKGQFERDLQA 1582



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 182/852 (21%), Positives = 354/852 (41%), Gaps = 131/852 (15%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQE--FNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            QQ  AE +K+  + L  ++QLE+E    QK    K    AK + L+ +  V+    + L 
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
              R  L E  +++    A     E  K + + ++K +    ++ L+  +K+     E + 
Sbjct: 999  KERKLLEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKK-----EEKS 1049

Query: 133  HLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
               LE+ + +          +IADL+ +++E      L+ ++ K +E+   L++ +  ++
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAE------LKMQLAKKEEE---LQAALARLD 1100

Query: 193  KEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDA 252
             EIA   + L     KI+ELE   + +L   L++E++ R   E        QK  L E+ 
Sbjct: 1101 DEIAQKNNAL----KKIRELE-GHISDLQEDLDSERAARNKAE-------KQKRDLGEEL 1148

Query: 253  EKLRKELHEVCH--LLEQE-RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
            E L+ EL +       +QE R +  Q     +KA D+   S    +++M++       E 
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 310  LRQVEELKK-KDQEDDEQQRLNKRK-----------------DHKKADVEEEIKIPVVCA 351
              Q+E+ K+ K   D  +Q L K                   +HKK  +E +++      
Sbjct: 1209 TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC 1268

Query: 352  LTQEESSAQLSNE----EEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQS 407
               E + A+L+++    +  ++S  G ++  +   +  + D  S S        L + ++
Sbjct: 1269 SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328

Query: 408  TDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFM 467
               L  S  L+      N        LDE     +    ++  +  T    ++Q+     
Sbjct: 1329 RQKLNVSTKLRQLEEERN---SLQDQLDEE----MEAKQNLERHISTL---NIQLSDSKK 1378

Query: 468  LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
              +D    ++A+   ++     + ++TQ  E      + Y  + +T+ N LQ+E+ +   
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEE---KAAAYDKLEKTK-NRLQQELDDLVV 1434

Query: 528  KLGRRCDMCSNYEKQLQGI------------------QIQEAETRDQVKKLQLMLR---- 565
             L  +  + SN EK+ +                       EAE R++  K   + R    
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494

Query: 566  --QANDQLEKTMKD-KQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR 622
              +A ++LE+T K  K E+ED +  S +D    +  L    +A E  +EE++  L + + 
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLV-SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 623  DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVL 682
            ++Q              +  +RL+ +  +L+G+    +   QA D    +    L+  + 
Sbjct: 1554 ELQ-----------ATEDAKLRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH 1599

Query: 683  KYR---EDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIA 739
            +Y    ED    R  A   ++KL+ ++  L  ++QA+  +K   E   QL     ++  A
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQL-----RKLQA 1652

Query: 740  SISSLKAELERIKVEKGQ--ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT-LQ 796
             +   + ELE  +  + +  AT +    E + KA+ L+ +L    Q+Q D     +   Q
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAK----ENEKKAKSLEADL---MQLQEDLAAAERARKQ 1705

Query: 797  VQLERIRQADSL 808
              LE+   A+ L
Sbjct: 1706 ADLEKEELAEEL 1717



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 162/801 (20%), Positives = 348/801 (43%), Gaps = 103/801 (12%)

Query: 50   YLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKR- 108
            +L +E DLK  + ++       G+L  + +  +   + + A+  +  N    A  +++  
Sbjct: 777  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKR--QQQLTAMKVIQRNCA--AYLKLRNW 832

Query: 109  QWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE 168
            QW      ++ +++ T ++ E Q     E E  +  + ++ AE E+ +L ++ S+  EE+
Sbjct: 833  QWWRLFTKVKPLLQVTRQEEEMQAK---EDELQKTKERQQKAENELKELEQKHSQLTEEK 889

Query: 169  NLENEMKKAQED----AEKLRSVVMPMEKEIAAL----KDKLTEAEDKIKELEASKVK-- 218
            NL  E  +A+ +    AE++R  +   ++E+  +    + +L E ED+ ++L+A + K  
Sbjct: 890  NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949

Query: 219  ----ELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHN 274
                +L   LE E++ R  L++        + V  E   K++K   E+  + +Q  +   
Sbjct: 950  QQMLDLEEQLEEEEAARQKLQL--------EKVTAE--AKIKKLEDEILVMDDQNNKLSK 999

Query: 275  QLKHTWQKAND------QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQR 328
            + K   ++ +D      +  E  + L +   + E +++  ++R    LKK+++   E ++
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR----LKKEEKSRQELEK 1055

Query: 329  LNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGD 388
            L ++ +   +D  E+I           E   QL+ +EE L +            L    D
Sbjct: 1056 LKRKLEGDASDFHEQI---ADLQAQIAELKMQLAKKEEELQAA-----------LARLDD 1101

Query: 389  PFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA--- 445
              ++ +N + K  +R  +     G    LQ   L     A++     + D G  + A   
Sbjct: 1102 EIAQKNNALKK--IRELE-----GHISDLQED-LDSERAARNKAEKQKRDLGEELEALKT 1153

Query: 446  ---DSVSENFDTASLGSLQMPSGFMLTK---DQERAIKAMTPE-QEETASLLSSVTQGME 498
               D++        L + +     +L K   ++ R+ +A   E +++ A  +  +T+ +E
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213

Query: 499  SAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVK 558
                + +      +T    L+KE  +   +L            ++ G   QE E +   K
Sbjct: 1214 QFKRAKANLDKNKQT----LEKENADLAGEL------------RVLGQAKQEVEHKK--K 1255

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            KL+  +++   +     + + EL D + +  ++    ++ ++  A+   I L +    LS
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKL-QNEVESVTGMLNEAEGKAIKLAKDVASLS 1314

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
               +D QE +    + +  VS +L +L+++ +SLQ +    +  +Q  +  +      L 
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCK 735
            +   K  +D  +   A +  +++ + EI  L +Q + +    + LE+T   LQ E+++  
Sbjct: 1375 DSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433

Query: 736  EEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTL 795
             ++ +   L + LE     K Q   +QL+ EEKN + +   E D +E   R+    + +L
Sbjct: 1434 VDLDNQRQLVSNLE-----KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL 1488

Query: 796  QVQLERIRQA-DSLERIRAIL 815
               LE   +A + LER   +L
Sbjct: 1489 ARALEEALEAKEELERTNKML 1509



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 159/818 (19%), Positives = 330/818 (40%), Gaps = 113/818 (13%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLA---KEEDLKRQNAVLQAAQDDLGHLRT 76
            ELEK+  +         ++    +A+  EL +    KEE+L+   A L        +   
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111

Query: 77   QLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRL 136
            ++ E +  + +++     SE   +   ++ KR   EE+ +L+  +++T+     Q  LR 
Sbjct: 1112 KIRELEGHISDLQEDLD-SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170

Query: 137  EQERTQWA------QYRESAEREIADLRRRLSEGQEE--ENLENEMKKAQEDAEKLRSVV 188
            ++E+          +   S E ++ ++R++ ++  EE  E LE + K+A+ + +K +   
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKANLDKNKQT- 1228

Query: 189  MPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVL 248
              +EKE A L  +L       +E+E  K K      E +  C +D E   A LN      
Sbjct: 1229 --LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARAELN------ 1279

Query: 249  QEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSE 308
             +   KL+ E+  V  +L +   +  +L       + Q  ++Q LL  + ++   V T  
Sbjct: 1280 -DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST-- 1336

Query: 309  QLRQVEELKK--KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
            +LRQ+EE +   +DQ D+E +         K ++E  I             + QLS+ ++
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEA--------KQNLERHIST----------LNIQLSDSKK 1378

Query: 367  HLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG-TSGSLQSK----A 421
             L     +V +L+ G        F K   ++ +    +A + D L  T   LQ +     
Sbjct: 1379 KLQDFASTVEALEEGK-----KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433

Query: 422  LGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTP 481
            +  + + +   NL++               FD        + S +    +++RA      
Sbjct: 1434 VDLDNQRQLVSNLEKKQ-----------RKFDQLLAEEKNISSKY--ADERDRAEAEARE 1480

Query: 482  EQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ------KEVHNAGNKLGRRCDM 535
            ++ +  SL  ++ + +E+        +++     +L+       K VH            
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 536  CSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQ 595
                + QL+ ++ +   T D   +L++ ++    Q E+ ++ + E  +  ++  +   H+
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGK 655
                +   +    L    ++ L    +D++ Q    ++ RE+  ++L +LQ      Q  
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ-- 1658

Query: 656  HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQA 715
                   ++ ED                 R++I       +   + L+A+++ L+E + A
Sbjct: 1659 -------RELED-------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAEL--ERIKVEKGQATVEQLMFEEK----- 768
                 E   +   LE E   EE+AS  S +  L  E+ ++E   A +E+ + EE+     
Sbjct: 1699 ----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 769  -----NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 801
                  KA +   +L      +R   + +++ + QLER
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 72/332 (21%), Positives = 138/332 (41%), Gaps = 67/332 (20%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAV---LQAAQDDL 71
            ++ + +L K+ A+    Q++LE      RA   E++   +E+ K+  ++   L   Q+DL
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDA----RASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
                    +A  E E + A    S  + + A+ + KR+    +A L+  ++E       Q
Sbjct: 1697 AAAERARKQADLEKEEL-AEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQ 1749

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM 191
             ++    +R + A                    Q+ E L NE+   +  A+K  S    +
Sbjct: 1750 GNMEAMSDRVRKAT-------------------QQAEQLSNELATERSTAQKNESARQQL 1790

Query: 192  EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQED 251
            E++   L+ KL E E  +K    SK K     LEA+ +    LE  V     +K    + 
Sbjct: 1791 ERQNKELRSKLHEMEGAVK----SKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKS 1843

Query: 252  AEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLR 311
             ++  K+L E+   +E ER+   Q K   +K N                           
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--------------------------A 1877

Query: 312  QVEELKKK-DQEDDEQQRLNKRKDHKKADVEE 342
            +V++LK++ ++ ++E QR+N  +   + +++E
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 3/103 (2%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD-- 70
            +L+ ++A+LE+   +  R +Q   +   QK  K KE+ L  E++ K      + A+    
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 71   -LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWRE 112
             +  L+ QL EA+ E + I A     +    EA +  +   RE
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score =  100 bits (248), Expect = 7e-21
 Identities = 176/849 (20%), Positives = 359/849 (42%), Gaps = 135/849 (15%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AEL K+  ++ R    L  E  +K  K ++      E+++++NA   A Q     L+ QL
Sbjct: 446  AELNKLRQDYAR----LVNELTEKTGKLQQ------EEVQKKNAEQAATQ-----LKVQL 490

Query: 79   WEAQAEMENIKAIA---TVSENTKQEAIDEVKRQWREEVASLQAVMKETV--RDYEHQFH 133
             EA+   E +++     T      Q+ +         EV SL + + +T+  +    Q  
Sbjct: 491  QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA----EKLRSVVM 189
            ++L +   +     ES + ++ D+  +    + +    +    AQ  A    E+L  V+ 
Sbjct: 551  MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610

Query: 190  PMEKEIAALKDKLTEAEDKI--KELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
              +K+I   +D L    D++  KE E   ++ +N  L+AE      ++   A+ N Q + 
Sbjct: 611  EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE------VQKLQALANEQAAA 664

Query: 248  LQEDAEKLRKELH---EVCHLLEQERQQHNQLK-HTWQKANDQFLESQRLLMRDMQRMEI 303
              E  EK+++ ++   +   LLE++ Q     K   ++  NDQ     + L  ++Q+++ 
Sbjct: 665  AHE-LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ----NKALKSEVQKLQ- 718

Query: 304  VLTSEQLRQ--VEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEES---- 357
             L SEQ  +  VE+++K  QE          KD K   VEE ++  ++   T+EE     
Sbjct: 719  TLVSEQPNKDVVEQMEKCIQE----------KDEKLKTVEELLETGLIQVATKEEELNAI 768

Query: 358  ---SAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTS 414
               ++ L+ E + L + +    S  A L+    +   K  ++  KDG  + +S + L   
Sbjct: 769  RTENSSLTKEVQDLKAKQNDQVSF-ASLV----EELKKVIHE--KDG--KIKSVEEL--- 816

Query: 415  GSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQER 474
              L+++ L    K K+  +L +          ++ E      L   Q  S  + +K QE 
Sbjct: 817  --LEAELLKVANKEKTVQDLKQE-------IKALKEEIGNVQLEKAQQLS--ITSKVQE- 864

Query: 475  AIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCD 534
             ++ +   +EE  + + +V +  E    +   +    + E   L+  V        +   
Sbjct: 865  -LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923

Query: 535  MCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSH 594
              S +E+    ++I   E  +++K+L+ ML++    L    +  Q+++D  K        
Sbjct: 924  SASQFEE----LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENK-------- 971

Query: 595  QISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQG 654
                 + ++Q  ++  +  QQ  S      +E + V+ +  +++S     L    D+++ 
Sbjct: 972  -----LFKSQIEQLKQQNYQQASSFPPH--EELLKVISEREKEISGLWNELDSLKDAVEH 1024

Query: 655  KHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE-----EKLKAEILFL 709
            +   +   QQ  + +  +  E L++L  K     ++V +   + E     EK   E +  
Sbjct: 1025 QRKKNNERQQQVEAVELEAKEVLKKLFPK-----VSVPSNLSYGEWLHGFEKKAKECMAG 1079

Query: 710  KEQIQAEQCLKENLEET------LQLEIENCKEEIASISSLKAELER----------IKV 753
                +  + L+  L+E       LQLE E  K  +A    +  +L+R          +KV
Sbjct: 1080 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1139

Query: 754  EKGQATVEQL---MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ-VQLERIRQADSLE 809
            ++   T++Q+       + + +RL++E    E ++R+   L   L+  ++ER      + 
Sbjct: 1140 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1199

Query: 810  RIRAILNDT 818
             ++A LN+T
Sbjct: 1200 ELKAQLNET 1208



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 94/419 (22%), Positives = 183/419 (43%), Gaps = 65/419 (15%)

Query: 14   LQQRVAEL-EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            L+Q +  L E+I    L   QQL      K  + + L   KEE +    AVL+  + DL 
Sbjct: 834  LKQEIKALKEEIGNVQLEKAQQLS--ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891

Query: 73   HLRTQLWEAQAEMENIKA-IATVSENTKQEA--------IDEVKRQWREEVASLQAVMKE 123
            +    L + Q E E++KA +  V+++  +EA        ++ V ++   E+  L+A++KE
Sbjct: 892  NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951

Query: 124  -------------TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE-EN 169
                          V+D    F  ++EQ + Q  Q   S      +L + +SE ++E   
Sbjct: 952  RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH-EELLKVISEREKEISG 1010

Query: 170  LENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKEL--------EASKVKELN 221
            L NE+   ++  E  R      ++++ A++    EA++ +K+L          S  + L+
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNERQQQVEAVE---LEAKEVLKKLFPKVSVPSNLSYGEWLH 1067

Query: 222  HYLEAEKSCRTD---------LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQ 272
             + +  K C            LE  +   +   ++LQ + EK +  L E   +L++ ++ 
Sbjct: 1068 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS 1127

Query: 273  HNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKR 332
              Q ++ W+   D   ES + +    ++M+   TS +    +EL++   E+ + + L + 
Sbjct: 1128 VEQEENKWKVKVD---ESHKTI----KQMQSSFTSSE----QELERLRSENKDIENLRRE 1176

Query: 333  KDH-----KKADVEEEIKIPVVCALTQE--ESSAQLSNEEEHLDSTRGSVHSLDAGLLL 384
            ++H     +KA++E    +  V  L  +  E+  +L  E+       G +H     L L
Sbjct: 1177 REHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLEL 1235



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 141/732 (19%), Positives = 295/732 (40%), Gaps = 104/732 (14%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE--EDLKRQNAVLQAAQDD 70
            SLQ +V ++ + N E L+AQ  ++Q  +Q  A+     LA+E  + +  ++  ++  +D 
Sbjct: 566  SLQMQVQDILEQN-EALKAQ--IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDS 622

Query: 71   LGHLRTQLWEAQAEMENIKAIATV--SENTKQEAIDEVKRQWREEVASLQA---VMKETV 125
            L   R +L   + E+++I+ +  +  +E  K +A+   +     E+  +Q    V  + +
Sbjct: 623  LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682

Query: 126  RDYEHQFHLRLEQERTQWA---QYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAE 182
            R  E Q    +  +  ++       ++ + E+  L+  +SE   ++ +E   K  QE  E
Sbjct: 683  RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742

Query: 183  KLRSV----------VMPMEKEIAALKDKLTEAEDKIKELEAS----------------- 215
            KL++V          V   E+E+ A++ + +    ++++L+A                  
Sbjct: 743  KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802

Query: 216  ------KVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                  K+K +   LEAE     + E  V  L  +   L+E+   ++ E  +   +  + 
Sbjct: 803  IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKV 862

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
            ++  N L     K  ++ + + + ++ + ++ ++  T + L+ ++E  +  +   ++   
Sbjct: 863  QELQNLL-----KGKEEQMNTMKAVLEEKEK-DLANTGKWLQDLQEENESLKAHVQEVAQ 916

Query: 330  NKRKDHKKADVEEEIKIPVVCALTQEES-----SAQLSNEEEHLDSTRGSVHSL-DAGLL 383
            +  K+   A   EE++I     L ++E+      A L   E  L S    +  + D   L
Sbjct: 917  HNLKEASSASQFEELEI----VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL 972

Query: 384  LPSGDPFSKSDN-----------DMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAG 432
              S     K  N           ++ K    R +    L         A+ +  K K+  
Sbjct: 973  FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRK-KNNE 1031

Query: 433  NLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAM--TPEQEETASLL 490
               + +   L   + + + F   S+ S  +  G  L   +++A + M  T   EE   L 
Sbjct: 1032 RQQQVEAVELEAKEVLKKLFPKVSVPS-NLSYGEWLHGFEKKAKECMAGTSGSEEVKVLE 1090

Query: 491  SSVTQGMES---AYVSPSGYR-LVSETEWNL--LQKEVHNAGNKLGRRCDMCSNYEKQLQ 544
              + +  E      +    Y+ +++ETE  L  LQ+ V    NK   + D      KQ+Q
Sbjct: 1091 HKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1150

Query: 545  GIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELE-DFIKQSSEDSSHQISALVLRA 603
                   +  ++       LR  N  +E   ++++ LE +  K   E S++      L+A
Sbjct: 1151 SSFTSSEQELER-------LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKA 1203

Query: 604  QASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQG--------- 654
            Q +E L +   +     ++ V   +    QS E +  ++V+   D   ++          
Sbjct: 1204 QLNETLTKLRTE--QNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETES 1261

Query: 655  --KHSLHVSLQQ 664
              K ++ VSL Q
Sbjct: 1262 SEKETMSVSLNQ 1273



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 71/368 (19%), Positives = 161/368 (43%), Gaps = 44/368 (11%)

Query: 468 LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
           L K  +  +  +  + +E   LL++V +       + +  R    T+  + +KE  N   
Sbjct: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKED-----AAATKDRCKQLTQEMMTEKERSNV-- 371

Query: 528 KLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQ 587
            + R  D     EK+    Q +   +  + +++Q+  +Q  +Q+E  +   ++    ++ 
Sbjct: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431

Query: 588 SSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQK 647
           +  ++++Q+ +     Q++E  L +L+Q  ++   ++ E+   L Q           +QK
Sbjct: 432 AVSNTTNQLES----KQSAE--LNKLRQDYARLVNELTEKTGKLQQE---------EVQK 476

Query: 648 DNDSLQGKHSLHVSLQQAE-------DFILPDTTE---ALRELVLKYREDIINVRTAADH 697
            N + Q    L V LQ+AE        +I   T E   A ++L  K+      V++    
Sbjct: 477 KN-AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535

Query: 698 VEEKL--KAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEK 755
           + + L  K ++     Q+   +  + N EE+LQ+++++  E+     +LKA++++   + 
Sbjct: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ---NEALKAQIQQFHSQI 592

Query: 756 GQATVEQLMFEEKNKA------QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 809
              T   ++ EE +K       Q  QTE  ++ +  R   K  +   +Q         ++
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652

Query: 810 RIRAILND 817
           +++A+ N+
Sbjct: 653 KLQALANE 660


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  100 bits (248), Expect = 7e-21
 Identities = 178/863 (20%), Positives = 370/863 (42%), Gaps = 120/863 (13%)

Query: 14   LQQRVAELEKINAE---FLRAQQQLEQEFNQKRAKFKE---LYLAKEEDLKRQNAVLQAA 67
            LQQ + E++ +  E     + Q+ L+ E +Q ++   +   + +  +E L+     L+  
Sbjct: 917  LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976

Query: 68   QDDLGHLRTQLWEAQAE---MENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKET 124
            Q+ +  L++++ E  +    ME            K   ID+ +    +   +L A +K+ 
Sbjct: 977  QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036

Query: 125  VRDYEHQFHLRLEQERTQWAQYRES--AEREI--ADLRRRLS---EGQEEENL-ENEMKK 176
                + +    L QE+ +  Q  ES  AE+E    DL+  +    E QEE  L  +E+KK
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096

Query: 177  AQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEM 236
             QE   + ++  +  E E++   D+L E E+K+KE    K ++L              E 
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE----KSQQLQ-------------EK 1139

Query: 237  YVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
               +LN     +QE+  +++K+++E+ +L  + + +   L+H         +E++RL + 
Sbjct: 1140 QQQLLN-----VQEEMSEMQKKINEIENLKNELKNKELTLEH---------METERLELA 1185

Query: 297  DMQRMEIVLTSEQLRQVEELKKKDQEDDE-QQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                      +E   +V+ + K+ +   E Q+     +DH +  + E   I      T+E
Sbjct: 1186 QK-------LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE---IEATGLQTKE 1235

Query: 356  E---SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
            E   +   L   +E +D  R SV    A ++         +  D+ K   +  +    L 
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQII---------NTQDLEKSHTKLQEEIPVLH 1286

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQ 472
                L       +   ++   L+      L+   S ++  D+ +L  ++M    +  K Q
Sbjct: 1287 EEQELLPNVKEVSETQETMNELE------LLTEQSTTK--DSTTLARIEMERLRLNEKFQ 1338

Query: 473  E--RAIKAMTPEQEETASLLSS--VTQGMESAYVSPSGYRL---VSETEWNLLQKEVHNA 525
            E    IK++T E++   ++  +  V       ++  +  ++    S+ E +L  KE  N 
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDK---QELE 582
              K+    +     +  L  I+I       ++  L   L++++D+++   K+K   Q L+
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEI-------EMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451

Query: 583  DFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL 642
            + ++  S+     I  +V +   +E  L+     L + +  + E    L +   ++S   
Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1511

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL--VLKYREDIINVRTAADHVEE 700
             +L+  ND LQ K  +    ++ E F +   +E   ++  + +++E     R A D   +
Sbjct: 1512 KQLEAINDKLQNK--IQEIYEKEEQFNIKQISEVQEKVNELKQFKEH----RKAKDSALQ 1565

Query: 701  KLKAEILFLKEQIQAEQ-----CLKE-----NLEETLQLE----IENCKEEIASI-SSLK 745
             +++++L L  ++Q  Q      +KE      ++E LQ+E     EN KE +A +  S +
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625

Query: 746  AELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA 805
             E + +K+     T E+ M E ++  ++ +T+    E ++ + ++L+Q L   LE +R  
Sbjct: 1626 KEYQFLKMTAVNETQEK-MCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684

Query: 806  DSLERIRAILNDTKLTDINQLPE 828
                     + +T   + +QL E
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKE 1707



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 169/868 (19%), Positives = 364/868 (41%), Gaps = 133/868 (15%)

Query: 20   ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLW 79
            EL  +  E  + Q+ + QE N          + KE +L R    L   ++ L     QL 
Sbjct: 1086 ELRLLGDELKKQQEIVAQEKNHA--------IKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137

Query: 80   EAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQE 139
            E Q ++ N+           QE + E++++  E + +L+  +K      EH     +E E
Sbjct: 1138 EKQQQLLNV-----------QEEMSEMQKKINE-IENLKNELKNKELTLEH-----METE 1180

Query: 140  RTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALK 199
            R + AQ       E+  + +      E + L+   K  + + + LR  +  +E      K
Sbjct: 1181 RLELAQKLNENYEEVKSITK------ERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234

Query: 200  DKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKEL 259
            ++L  A   +KE          H    ++  R+  E    ++NTQ      D EK   +L
Sbjct: 1235 EELKIAHIHLKE----------HQETIDELRRSVSEKTAQIINTQ------DLEKSHTKL 1278

Query: 260  HEVCHLLEQERQ---QHNQLKHTWQKANDQFLESQRLLMRDMQ-----RMEIVLTSEQLR 311
             E   +L +E++      ++  T +  N+  L +++   +D        ME +  +E+ +
Sbjct: 1279 QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338

Query: 312  QV-EELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDS 370
            +  EE+K   +E D  + + +  + K   ++E I+  +      +    Q  N +E  + 
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398

Query: 371  TRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKS 430
            T   V  ++          F   D+ + +  +      + LG S  LQ         AK 
Sbjct: 1399 TTKIVSEMEQ---------FKPKDSALLRIEI------EMLGLSKRLQESHDEMKSVAKE 1443

Query: 431  AGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLT----KDQERAIKAMTPEQEET 486
              +L          +D + EN        L+      +     K+QE  I  +     E 
Sbjct: 1444 KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEK 1503

Query: 487  ASLLSSVTQGMESA---YVSPSGYRLVSETEWNLLQ-KEVHNAGNKLGRRCDMCSNYEKQ 542
             + +S++ + +E+      +        E ++N+ Q  EV    N+L +  +     +  
Sbjct: 1504 ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA 1563

Query: 543  LQGIQ---------IQEAET--------RDQVKKLQLMLRQANDQLEKT-------MKDK 578
            LQ I+         +QE++         ++++K++Q  L+   DQL++        MK+ 
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623

Query: 579  QELE-DFIKQSSEDSSHQ----ISALVLRAQASEILLEELQQG---LSQAKRDVQEQMAV 630
            QE E  F+K ++ + + +    I  L  + +  ++ LE ++     L+Q   +  E+M  
Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683

Query: 631  LMQSREQVS--EELVRLQKDNDSLQGKHSLHVSLQQAEDFIL--------PDTTEALREL 680
            + + R+ +   EE +++++D      + ++   L++ E+  +         +T + LR +
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743

Query: 681  VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
            V +   +I N++   +H  + LKA+ L ++E+++      +  +ET+        E+   
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803

Query: 741  ISSLKAELE------RIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT 794
            +S+++ +LE      + K+++ +A   QL+  +K+     Q ++   EQ+++     S T
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD-VNETQKKVSEMEQLKKQIKDQSLT 1862

Query: 795  L-QVQLERIRQA----DSLERIRAILND 817
            L ++++E +  A    ++LE +++++ +
Sbjct: 1863 LSKLEIENLNLAQKLHENLEEMKSVMKE 1890



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 177/836 (21%), Positives = 351/836 (41%), Gaps = 137/836 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE-EDLKRQNAVLQAAQD 69
            +V   Q    + +  A+   +Q + EQ  N K    +   +  E E  K +++ L   + 
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421

Query: 70   DLGHLRTQLWEAQAEMENIKAIATVSENTK--QEAIDEVKRQWREEVASLQAVMKETVRD 127
            ++  L  +L E+  EM   K++A   ++ +  QE +     Q +E +  + A   ET  +
Sbjct: 1422 EMLGLSKRLQESHDEM---KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 128  YEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSV 187
             +       EQE T            I +LR  LSE  +E  +    K+ +   +KL++ 
Sbjct: 1479 LKVAHCCLKEQEET------------INELRVNLSE--KETEISTIQKQLEAINDKLQNK 1524

Query: 188  VMPM-EKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
            +  + EKE      +++E ++K+ EL     K+   + +A+ S    +E  +  L  +  
Sbjct: 1525 IQEIYEKEEQFNIKQISEVQEKVNEL-----KQFKEHRKAKDSALQSIESKMLELTNRLQ 1579

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLT 306
              QE+ + + KE  E+  + E  + + +QLK   ++   +  ESQ    + ++   +  T
Sbjct: 1580 ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET 1639

Query: 307  SEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
             E++ ++E LK    E  E Q+LN           E I++  +     EE  + ++ E +
Sbjct: 1640 QEKMCEIEHLK----EQFETQKLNLENIE-----TENIRLTQILHENLEEMRS-VTKERD 1689

Query: 367  HLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNY 426
             L S   ++                K + D  K+ LR   + D        + K +  + 
Sbjct: 1690 DLRSVEETL----------------KVERDQLKENLRETITRD---LEKQEELKIVHMHL 1730

Query: 427  KAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD----QERAIKAM-TP 481
            K        +     L G  S   N  +     L+  +  +  +D    +E  I  M   
Sbjct: 1731 KE------HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784

Query: 482  EQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEK 541
            EQ+ET   L  +        VS    +L +      +QK++ N+  KL  +       E 
Sbjct: 1785 EQQETIDKLRGI--------VSEKTDKLSN------MQKDLENSNAKLQEKIQELKANEH 1830

Query: 542  QLQGIQIQEAETRDQVKKLQLMLRQANDQ--------------LEKTMKDKQELEDFIKQ 587
            QL  ++    ET+ +V +++ + +Q  DQ               +K  ++ +E++  +K+
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890

Query: 588  SSEDSSHQISALVLRAQASEILLE------ELQQGLSQAKRDVQEQMAVLMQSREQVSEE 641
                   + +  + R Q  E L E      E+QQ L  A+   +E    + + RE++SE+
Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950

Query: 642  LVR---LQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL-VLKYREDIINVRTAADH 697
             ++   +QKD D  + K  L   +Q+ +           +EL +L+ +ED+        +
Sbjct: 1951 TIQISDIQKDLD--KSKDELQKKIQELQK----------KELQLLRVKEDV--------N 1990

Query: 698  VEEKLKAEILFLKEQIQAEQCLKENLE-ETLQL--EIENCKEEIASISSLKAELERI--- 751
            +  K   E+  LK+Q +A+    +++  +  QL  ++    EEI  ++  + EL RI   
Sbjct: 1991 MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES 2050

Query: 752  -KVEKGQ--ATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQ 804
             K+E+ Q  AT+ +++  ++   Q    +  +S+  Q     L+++L+ +  RI++
Sbjct: 2051 LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH----LTESLREKCSRIKE 2102



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 165/930 (17%), Positives = 369/930 (39%), Gaps = 201/930 (21%)

Query: 32   QQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAI 91
            Q++L +E  +  A  +E+ L  E  LK   + ++  + ++     +L    +E + + + 
Sbjct: 726  QKELNKEVEENEALREEVILLSE--LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE 783

Query: 92   ATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEH--QFHLRLEQERTQWAQYRES 149
                E+  Q  ++E+ +  ++++A+ Q+  K T +++++    H+  EQ+     +  E 
Sbjct: 784  VVHKESRVQGLLEEIGKT-KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842

Query: 150  AEREIADLRRRLSE----------------------GQEEENLENEMKKAQEDAEKLRSV 187
              +EI +L +   +                       +E +   NEM++ +E  E   S 
Sbjct: 843  MNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDST 902

Query: 188  VMPMEKEIAALKDKLTEAEDKIKEL--EASKVKELNHYLEAE------------------ 227
            +  +E+E   + +KL +  +++K L  E   +K+L   L+ E                  
Sbjct: 903  LQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDT 962

Query: 228  ----KSCRTDLEMYVAVLNTQKSVLQEDAEK---LRKELHEVCHLLEQ-----ERQQHNQ 275
                ++    L+ +   +NT KS + E+  +   + +   E     +Q     +++Q  +
Sbjct: 963  QEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLE 1022

Query: 276  LKHTWQKAND----QFLESQRLLM------RDMQRM--EIVLTSEQLR------------ 311
             K+T     D    + +E QR +        ++Q+M   ++   EQL+            
Sbjct: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE 1082

Query: 312  QVEELKKKDQEDDEQQRL-NKRKDH-------------KKADVEEEIKIPVVCALTQEES 357
              EEL+    E  +QQ +  + K+H             + A+VEE++K          E 
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK----------EK 1132

Query: 358  SAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST-DSLGTSGS 416
            S QL  +++ L + +  +  +   +          ++ +  K+ L+  + T + + T   
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKI----------NEIENLKNELKNKELTLEHMETERL 1182

Query: 417  LQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAI 476
              ++ L  NY+   +   +      L  +     +     +  ++     + TK++ +  
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG--LQTKEELKIA 1240

Query: 477  KAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQ-KEVHNAGNKLGRRCDM 535
                 E +ET   L                 R VSE    ++  +++  +  KL     +
Sbjct: 1241 HIHLKEHQETIDELR----------------RSVSEKTAQIINTQDLEKSHTKLQEEIPV 1284

Query: 536  CSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF-IKQSSEDSSH 594
                ++ L  ++ + +ET++ + +L+L+  Q+  + + T   + E+E   + +  ++S  
Sbjct: 1285 LHEEQELLPNVK-EVSETQETMNELELLTEQSTTK-DSTTLARIEMERLRLNEKFQESQE 1342

Query: 595  QISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDS--- 651
            +I +L       + + E L+    Q K  ++E +A + +S+ +  + L   +KDN++   
Sbjct: 1343 EIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKI 1402

Query: 652  ---------------------------LQGKHSLHVSLQQAEDFILPDTTEALRELVLKY 684
                                       LQ  H    S+ + +D  L    E L+    + 
Sbjct: 1403 VSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD-DLQRLQEVLQSESDQL 1461

Query: 685  REDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEE------TLQLEIENC---- 734
            +E+I  +       EE+LK     LKEQ +    L+ NL E      T+Q ++E      
Sbjct: 1462 KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKL 1521

Query: 735  ---------KEE---IASISSLKAELERIK--------VEKGQATVEQLMFEEKNKAQRL 774
                     KEE   I  IS ++ ++  +K         +    ++E  M E  N+ Q  
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES 1581

Query: 775  QTELDVSEQVQRDFVKLSQTLQVQLERIRQ 804
            Q E+ +  + + +  ++ + LQ++ +++++
Sbjct: 1582 QEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 186/934 (19%), Positives = 389/934 (41%), Gaps = 165/934 (17%)

Query: 18   VAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEE----------DLKRQNAVLQAA 67
            ++E+E   A  L  Q+ +E E N  RA +  L L  E+           LK +N + +  
Sbjct: 479  LSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFE 538

Query: 68   QDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVK------RQWREEVASLQAVM 121
              +    + Q  +   E+ N+K +   +E   Q+  +E+       R+  +++  LQ  +
Sbjct: 539  ALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI 598

Query: 122  K---------------ETVRDYEHQFHLRLEQERTQWAQYRESA--EREIADLRRRLSE- 163
                            E++ D +       + E       RESA    E  +L+ ++ E 
Sbjct: 599  DSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKEL 658

Query: 164  GQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLT------------------EA 205
                + +EN+++  Q   E  + + + +EKE+ +  +++T                  E 
Sbjct: 659  ATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLEL 718

Query: 206  EDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELH----- 260
            E KI +L+    KELN  +E  ++ R ++     +L ++   L  + E+LRKE+      
Sbjct: 719  EGKITDLQ----KELNKEVEENEALREEV-----ILLSELKSLPSEVERLRKEIQDKSEE 769

Query: 261  -------------EVCH-------LLEQERQQHNQLKHTWQ--KANDQ-----------F 287
                         EV H       LLE+  +  + L  T    K+ DQ           F
Sbjct: 770  LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829

Query: 288  LESQRLLMRDMQRM--EIVLTSEQLRQVE--------ELKKKDQEDDEQQRLNKRKDHKK 337
             +  ++++ + +RM  EIV  S++ ++ +        EL  K QE  E+ R  + + ++ 
Sbjct: 830  EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889

Query: 338  ADVEEEIKIPVVCALTQE-------ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPF 390
              ++E+++       T E       E   Q   E + L   +  +  L   L +      
Sbjct: 890  EQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ-- 947

Query: 391  SKSD-------NDMFKDGLRRA-----QSTDSLGTSGSLQSKALGYN-YKAKSAGNLDES 437
             KSD       N   ++ LR A     Q  +++ T  S  S+ +  N +  ++ G   + 
Sbjct: 948  LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007

Query: 438  DFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGM 497
                +VG D   ++ +  +  +L          +Q+R I ++  E+ E   +L SV    
Sbjct: 1008 FQQKMVGIDK-KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066

Query: 498  ESAYVSPSGYRLVSETEWNL-LQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQ 556
            E          L    E  +  Q+E+   G++L ++ ++ +  +      + + + T D+
Sbjct: 1067 EQLKTD-----LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR 1121

Query: 557  VKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQ- 615
            + +++  L++ + QL++  +    +++ + +  +   ++I  L    +  E+ LE ++  
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE-MQKKINEIENLKNELKNKELTLEHMETE 1180

Query: 616  --GLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQG--KHSLHVSLQQAEDFIL- 670
               L+Q   +  E++  + + R+ + E     + + D L+G  +      LQ  E+  + 
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240

Query: 671  -------PDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE-- 721
                    +T + LR  V +    IIN +   +    KL+ EI  L E+ +    +KE  
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQD-LEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299

Query: 722  NLEETLQLEIENCKEEIA---SISSLKAELERIKV-EKGQATVEQL--MFEEKNKAQRLQ 775
              +ET+  E+E   E+     S +  + E+ER+++ EK Q + E++  + +E++  + ++
Sbjct: 1300 ETQETMN-ELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIK 1358

Query: 776  TELDVSEQVQRDFVKLSQTL-QVQLERIRQADSL 808
              L+V     ++ ++  +TL ++Q  + +Q  SL
Sbjct: 1359 EALEVKHDQLKEHIR--ETLAKIQESQSKQEQSL 1390



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 167/887 (18%), Positives = 365/887 (41%), Gaps = 137/887 (15%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE-------------- 54
            + + ++ +    L +   E    Q+QLE   ++ + K +E+Y  +E              
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV 1547

Query: 55   -------EDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTK--QEAIDE 105
                   E  K +++ LQ+ +  +  L  +L E+Q   E I+ +    E  K  QEA+  
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ---EEIQIMIKEKEEMKRVQEALQI 1604

Query: 106  VKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQ 165
             + Q +E    + A MKE+ ++ E+QF        TQ         +E  + ++   E  
Sbjct: 1605 ERDQLKENTKEIVAKMKES-QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663

Query: 166  EEENLE---------NEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASK 216
            E EN+           EM+   ++ + LRSV   ++ E   LK+ L E   +  E +  +
Sbjct: 1664 ETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE-KQEE 1722

Query: 217  VKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE-----------KLRKELHEVCHL 265
            +K ++ +L+  +     L   V+    + S +Q+D E           K+++EL      
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782

Query: 266  LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDE 325
            L+++++  ++L+    +  D+    Q+ L     +++  +   +  + + +  K   ++ 
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842

Query: 326  QQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLP 385
            Q+++++ +  KK   ++ + +    +  + E+        E+L+  +  +   D    L 
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTL----SKLEIENLNLAQKLHENLEEMKSVMKERDN---LR 1895

Query: 386  SGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGA 445
              +   K + D  K+ L+  ++ D            L    + K+A  L +         
Sbjct: 1896 RVEETLKLERDQLKESLQETKARD------------LEIQQELKTARMLSKEH------K 1937

Query: 446  DSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPS 505
            ++V +  +  S  ++Q+     + KD +++   +  + +E       + +  E   +S  
Sbjct: 1938 ETVDKLREKISEKTIQISD---IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS-- 1992

Query: 506  GYRLVSETEWNLLQKEVHNAGNKLGR--RCDMCSNYEKQLQGIQIQEAETRDQVKKLQLM 563
             ++ ++E E    Q E  N   +  R     +     + L+ I+I  A+ RD++++++  
Sbjct: 1993 -HKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELRRIKES 2050

Query: 564  LRQANDQLEKTMKDKQELEDFIKQSSEDSSHQIS-ALVLRAQASEILLEELQQGLSQAKR 622
            L+   DQ   T+++          + +  +HQ+     L +   + L E L++  S+ K 
Sbjct: 2051 LKMERDQFIATLRE--------MIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKE 2102

Query: 623  ------------DVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQQAEDFI 669
                        +   ++++ ++   +  +EL    K N SL    + H+  L  A    
Sbjct: 2103 LLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRC 2162

Query: 670  LPDTTEALREL--VLKY-------REDIINVRTAADHVEEKLKAEILFLKEQIQAEQC-- 718
              +    +++L  VL Y       + + IN +   D ++E  K + L +K Q   + C  
Sbjct: 2163 SMEFHRIMKKLKYVLSYVTKIKEEQHESIN-KFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221

Query: 719  ----LKE-NLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQR 773
                L++  L + + L IE   ++ +     ++E   IK E      +Q++   K   Q 
Sbjct: 2222 PSRELRDLKLNQNMDLHIEEILKDFS-----ESEFPSIKTE-----FQQVLSNRKEMTQF 2271

Query: 774  LQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSL--ERIRAILNDT 818
            L+  L+     + D  KL   +Q + +RI Q ++    RI AI+N++
Sbjct: 2272 LEEWLN----TRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNES 2314



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 114/649 (17%), Positives = 263/649 (40%), Gaps = 79/649 (12%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            SLQ+  A   +I  E L+  + L +E  +   K +E    K   +      L  ++D+L 
Sbjct: 1911 SLQETKARDLEIQQE-LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ 1969

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQF 132
                +L + + ++  +K    +S     E ++++K+Q+  +  S+Q+V  +  +    + 
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINE-MEQLKKQFEAQNLSMQSVRMDNFQ-LTKKL 2027

Query: 133  HLRLEQ------ERTQWAQYRESAERE----IADLRRRLSEGQEEENLENEMKKAQEDAE 182
            H  LE+      ER +  + +ES + E    IA LR  ++  ++   ++ E +   +  +
Sbjct: 2028 HESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087

Query: 183  KLRSVVMPMEKEIAALKDKLTEAEDK---IKELEASKVKELNHYLEAEKSCRTDLEM-YV 238
             L   +      I  L  + +E +D    +  L     KE+    E     + +L + Y+
Sbjct: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
               + +K  L    ++   E H +   L+       ++K    ++ ++F      +    
Sbjct: 2148 QTKHIEK--LFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF--EMDFIDEVE 2203

Query: 299  QRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESS 358
            ++ E+++  + L+Q  ++  ++  D    +LN+  D     +EE +K       ++ E  
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRD---LKLNQNMD---LHIEEILK-----DFSESEFP 2252

Query: 359  AQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQ 418
            +  +  ++ L + +     L+  L        ++ D +  K+G+++              
Sbjct: 2253 SIKTEFQQVLSNRKEMTQFLEEWLN-------TRFDIEKLKNGIQKE------------- 2292

Query: 419  SKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKA 478
                  N +     N   +    ++   + S  F+  S           ++K+ E+ +K+
Sbjct: 2293 ------NDRICQVNNFFNNR---IIAIMNESTEFEERSA---------TISKEWEQDLKS 2334

Query: 479  MTPEQEETASLLSSVTQGMES-AYVSPSGYRL----VSETEWNLLQKEVHNAGNKLGRRC 533
            +  + E+      ++   + S A V+P+        V+     L  +++    N L    
Sbjct: 2335 LKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK 2394

Query: 534  DMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSS 593
            +   + E ++  +Q +   T D + KLQ  + ++N  LEKT +  Q L+D +   ++   
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK 2454

Query: 594  HQISALVLRAQASEI----LLEELQQGLSQAKRDVQEQMAVLMQSREQV 638
             +I  L ++    ++      +E ++ +S  K  V+ Q  V+   RE +
Sbjct: 2455 EEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENL 2503



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 122/673 (18%), Positives = 278/673 (41%), Gaps = 80/673 (11%)

Query: 167  EENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEA 226
            +EN+E+E+   + D + L   V+  E+    L+ +  E E K+KE       +L+ +   
Sbjct: 493  QENIESELNSLRADYDNL---VLDYEQ----LRTEKEEMELKLKEKN-----DLDEFEAL 540

Query: 227  EKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKEL-HEVCHLLEQERQQHNQLKHTWQKAND 285
            E+  + D EM +    +    L + AE   ++L +E+   +E  R++ +Q+K        
Sbjct: 541  ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKL-----Q 595

Query: 286  QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH-----KKADV 340
            ++++SQ+L   +  +M++  + E +   +++ K+   D E   L+ +++      +  ++
Sbjct: 596  EYIDSQKL---ENIKMDLSYSLESIEDPKQM-KQTLFDAETVALDAKRESAFLRSENLEL 651

Query: 341  EEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFK- 399
            +E++K     A T ++    +   +  L++ +     L+  L          + N++ K 
Sbjct: 652  KEKMK---ELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL--------QSAFNEITKL 700

Query: 400  ----DGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDF--GPLVGADSVSENFD 453
                DG        +L   G +       N + +    L E       L    S  E   
Sbjct: 701  TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760

Query: 454  TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET 513
                   +     ++T ++++    +  ++     LL  + +  +    + S Y+   + 
Sbjct: 761  KEIQDKSE--ELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818

Query: 514  EWNLLQKEVH-NAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLE 572
              N   K +H +   K     +      +++  +  +  +    +  L+  L     +L+
Sbjct: 819  FQNF--KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876

Query: 573  KTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLM 632
            +  ++ QE  + ++Q  E   ++ S L    +   ++ E+LQQ L        E++  L 
Sbjct: 877  EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL--------EEVKTLT 928

Query: 633  QSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELV--LKYREDIIN 690
            Q ++ + +    LQ + D L  K  +H ++      +  DT E LR  +  LK  ++ IN
Sbjct: 929  QEKDDLKQLQESLQIERDQL--KSDIHDTVN-----MNIDTQEQLRNALESLKQHQETIN 981

Query: 691  VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKE---EIASISSLKAE 747
                   ++ K+  E+      +  E+   E  +E  Q  +   K+   E  +  +L A+
Sbjct: 982  T------LKSKISEEV---SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032

Query: 748  LERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVK-LSQTLQVQLERIRQAD 806
            ++  ++ + Q  +  L+ E+    Q L++ +   EQ++ D  + +  T++ Q E     D
Sbjct: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092

Query: 807  SLERIRAILNDTK 819
             L++ + I+   K
Sbjct: 1093 ELKKQQEIVAQEK 1105



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 80/417 (19%), Positives = 172/417 (41%), Gaps = 77/417 (18%)

Query: 11   DVSLQQRV-AELEKINAEFLRAQ-QQLEQEFNQKRAKFKELYLAKEE------DLKRQNA 62
            D+ L Q +   +E+I  +F  ++   ++ EF Q  +  KE+    EE      D+++   
Sbjct: 2228 DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287

Query: 63   VLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTK-QEAIDEVKRQWREEVASLQAVM 121
             +Q   D +  +            N + IA ++E+T+ +E    + ++W +++ SL+   
Sbjct: 2288 GIQKENDRICQVNNFF--------NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKN 2339

Query: 122  KETVRDYEHQFHLRLEQERTQWAQYRESAE-REIADLRRRLSEGQEEE--NLENEMKKAQ 178
            ++  ++Y+      L+      AQ   + +  +   +  R ++   E+   LEN + +A+
Sbjct: 2340 EKLFKNYQ-----TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK 2394

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAE--------K 228
            E A    S ++ M+KE+    D + + + K+ E      K KE    L+ +        K
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK 2454

Query: 229  SCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTW---QKAND 285
                DL+M +  ++ +K    ++A++  KE+      +E +++    L+      Q+A D
Sbjct: 2455 EEIEDLKMKLVKIDLEK---MKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQD 2511

Query: 286  QFLESQRLLMRDMQR--------------MEIVLTSEQLRQVEELKKKDQEDDE------ 325
              + S+    +   +                ++L SE +R  +E+ K  Q++++      
Sbjct: 2512 TSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKN 2571

Query: 326  ----------------QQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
                            ++R  KR+ HK+   E   K P V     ++     S  +E
Sbjct: 2572 ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKE 2628


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 188/839 (22%), Positives = 351/839 (41%), Gaps = 146/839 (17%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKR---QNAVLQAAQDDL 71
            +  V +  ++  E  R+ +QLEQ   ++    KEL   +E  L R   Q  +LQA + ++
Sbjct: 648  EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA-LSRATLQRDMLQAEKAEV 706

Query: 72   GHLRTQLWEAQAEME---------------NIKAIATVSENTKQEAID--EVKRQWREEV 114
                T+    + E+E               ++  ++ ++E+  Q+ +D   +  Q  EE 
Sbjct: 707  AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766

Query: 115  ASL-----QAVMKETV--RDYEHQFHLRLEQERTQWA---------QYRESAEREIADLR 158
            ++L     QA  + TV   + E    LRLEQE  +           Q +E+ E+++  LR
Sbjct: 767  SALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLR 826

Query: 159  RRLSEGQE------------EENLENEMKKAQEDAEKLRSVVMPME---KEIAALKDKLT 203
               S+ QE            E+ LE   ++AQ   E L       E   KE A L  +L 
Sbjct: 827  HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV 886

Query: 204  EAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVC 263
             AE + + L + +   L    EA +    +++  +A L  ++  L+ + + L      + 
Sbjct: 887  AAEREGRTL-SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLT 945

Query: 264  HLLEQERQQHNQLKHTWQKAN-DQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQE 322
              L   RQ   Q+  T +KA+ D+ L +Q+L+            +E+  Q    +++   
Sbjct: 946  GELAGLRQ---QIIATQEKASLDKELMAQKLVQ-----------AEREAQASLREQRAAH 991

Query: 323  DDEQQRLNKRKDHKKADVE-EEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSV-HSLDA 380
            +++ QRL + K+    ++E E  ++       QEE  A+L  E+E L     ++    D 
Sbjct: 992  EEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE 1051

Query: 381  GLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFG 440
            GLLL   +   K      K+  + A S   +GT  SL + +L    + + A +  E D  
Sbjct: 1052 GLLLAESE---KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108

Query: 441  PLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE----QEETASLLSSVTQG 496
             +        N  T+ L  L+          +E A  A   E    QE+   L       
Sbjct: 1109 TV--------NALTSELRDLR--------AQREEAAAAHAQEVRRLQEQARDLGKQRDSC 1152

Query: 497  MESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQ 556
            +  A    +  RL+ +   + L++E+  A  KL           +  +G ++Q  E  + 
Sbjct: 1153 LREAEELRTQLRLLEDAR-DGLRRELLEAQRKL----------RESQEGREVQRQEAGEL 1201

Query: 557  VKKL------QLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL-----VLRAQA 605
             + L      +  LR++N++L   +K  +     +K ++ED   +++ L      +  +A
Sbjct: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEA 1261

Query: 606  SEIL--LEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQ 663
             E+   L+E+++   +A+R++QE    L +  + +  E  RL ++   LQG+ +L    +
Sbjct: 1262 GELRTGLQEVERSRLEARRELQE----LRRQMKMLDSENTRLGRELAELQGRLALG---E 1314

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLK--------AEILFLKEQIQA 715
            +AE     +T   LR+ +LK    +  +R      + KL+         E   L    +A
Sbjct: 1315 RAEKESRRETL-GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373

Query: 716  EQCLKENLEET--LQLEIENCKEEIASI-----------SSLKAELERIKVEKGQATVE 761
                K+ L+    L+L++E  + E A +             L+AEL R++V++  A  +
Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 161/790 (20%), Positives = 328/790 (41%), Gaps = 96/790 (12%)

Query: 84  EMENIKAIATVSENTKQEA--IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
           EM ++ ++   ++  +QE   ++++  Q R E   L A+    V +   Q  LRLE    
Sbjct: 72  EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDEL-AIKYNAVSERLEQA-LRLEPGEL 129

Query: 142 QWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDK 201
           +  + R    R+  +LRR+L E  E+ +   +++  QE  ++   +V  ++ +I   K +
Sbjct: 130 ETQEPR-GLVRQSVELRRQLQE--EQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186

Query: 202 LTEAEDKIKE----LEASKVKELNHY---------LEAEKSCRTDLEMYVAVLNTQKSVL 248
            +E E ++ E    LE  ++++  H          LE E+     L    A+L  Q    
Sbjct: 187 CSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQA 246

Query: 249 QEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFL-----ESQRLLM-------- 295
               + L +++ +V +   + R++    +  W++  + F      E  RLL+        
Sbjct: 247 GSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGF 306

Query: 296 ------------RDMQRM--EIVLTSEQLRQVE---ELKKKDQEDDEQQRLNKRKDHKKA 338
                       RD+ ++  E+  TS  +++         +  E   +  L K+    +A
Sbjct: 307 RRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQA-LLQA 365

Query: 339 DVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMF 398
            +EE+++  V+    +E+  AQ   + + LD    S    + GL +   +  +   + + 
Sbjct: 366 QLEEQLRDKVL----REKDLAQQQMQSD-LDKADLSARVTELGLAVKRLEKQNLEKDQVN 420

Query: 399 KDGLRRAQSTDSLGTSGSL-----QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFD 453
           KD   + ++ +SL             + L    +  +   L +S+ G  +   S SE   
Sbjct: 421 KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQL---SGSERTA 477

Query: 454 TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET 513
            AS GSL+  SG           +  +P +  +     S  +G   A    S   L+  +
Sbjct: 478 DASNGSLRGLSGQ----------RTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI-HS 526

Query: 514 EWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEK 573
             +  Q +V +   +     D+     KQL   + +     +Q+++L+     A    E 
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586

Query: 574 TMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEE------LQQGLSQAKRDVQEQ 627
             ++ Q L    +  S + S+   +L +  Q +E L +E       Q+ L + +  ++E+
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646

Query: 628 MAVLMQSREQVSEELVRLQKDNDSLQGKHS-LHVSLQQAEDFILPDTTEALRELVLKYRE 686
               +Q   +V  EL R  +  + L+GK S L   L +  + +   T +  R+++   + 
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQ--RDMLQAEKA 704

Query: 687 DIINVRTAAD--HVE-----EKLKAEILFLKEQIQAEQCLKENL-EETLQLE--IENCKE 736
           ++    T A+   VE      KL+AE   L++ +     L E+L ++ L L   +   +E
Sbjct: 705 EVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEE 764

Query: 737 EIASISSLK--AELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQT 794
           E +++   +  AE E     + Q  +E+L  E++   Q L+  L V+EQ Q    +   T
Sbjct: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPT 824

Query: 795 LQVQLERIRQ 804
           L+ +  ++++
Sbjct: 825 LRHERSQLQE 834



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 173/808 (21%), Positives = 326/808 (40%), Gaps = 104/808 (12%)

Query: 29   LRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQ--AEME 86
            LR+  +L        A   ++   + E+L+++   LQAAQ++L   R +L E Q  A  +
Sbjct: 594  LRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQD 653

Query: 87   NIKAIATVSENTKQEAIDEVKRQ--WREEVASLQAVMKETV-RDYEHQFHLRLEQERTQW 143
              +    +  + +Q    E KR    +E V   +A+ + T+ RD        L+ E+ + 
Sbjct: 654  GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD-------MLQAEKAEV 706

Query: 144  AQYRESAEREIADLRRRLSE-GQEEENLENEMKKAQ-------EDAEKLRSVVMPMEKEI 195
            A+    AE    +L   +++   EE +L++ + K         +D   L  +V  +E+E 
Sbjct: 707  AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766

Query: 196  AALKDKLTEAEDK--IKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAE 253
            +AL+ +  +AE +  +   E  +++EL   LE E + R  LE  + V    +  L++   
Sbjct: 767  SALQGRQRQAEQEATVAREEQERLEELR--LEQEVA-RQGLEGSLRVAEQAQEALEQQLP 823

Query: 254  KLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLL--MRDMQRMEIVLTSEQLR 311
             LR   HE   L EQ  Q   QL    Q+      E+QR +  +    R +  L  E   
Sbjct: 824  TLR---HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAG 880

Query: 312  QVEELKKKDQE----DDEQQRLNKRKDHKKADVEEEIKIPVVCALTQ-EESSAQLSNEEE 366
               +L   ++E     +E  RL   K+  +  + E     V   L Q E    QL  E +
Sbjct: 881  LAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE-----VQRQLAQLEARREQLEAEGQ 935

Query: 367  HLDSTRGSVHSLDAGL--LLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGY 424
             L   + ++    AGL   + +    +  D ++    L +A+         SL+ +   +
Sbjct: 936  ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE----AQASLREQRAAH 991

Query: 425  NYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQE 484
                       E D   L      +     A    LQ      L ++QE  +  +  E+E
Sbjct: 992  -----------EEDLQRLQREKEAAWRELEAERAQLQS----QLQREQEELLARLEAEKE 1036

Query: 485  ETASLLSSVTQ----GMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
            E +  ++++ Q    G+  A         + E+E   L +++    + L     +    E
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSL---ATISLEME 1093

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALV 600
            +Q +  Q ++ + R  V  L   LR    Q E+      +    +++ + D   Q  + +
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL 1153

Query: 601  LRAQASEI---LLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHS 657
              A+       LLE+ + GL +   + Q ++    + RE   +E   L++         S
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR---------S 1204

Query: 658  LHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL----KAEILFLKE-- 711
            L    ++ E   L  + E LR  V K   + I+++ A +  E+KL    +A     KE  
Sbjct: 1205 LGEGAKERE--ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262

Query: 712  ------------QIQAEQCLKENLEETLQLEIENCK--EEIASISSLKAELERIKVEKGQ 757
                        +++A + L+E   +   L+ EN +   E+A +    A  ER + E  +
Sbjct: 1263 ELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRR 1322

Query: 758  AT--VEQLMFEEKNKAQRLQTELDVSEQ 783
             T  + Q + + +   + ++ EL V+++
Sbjct: 1323 ETLGLRQRLLKGEASLEVMRQELQVAQR 1350



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 127/657 (19%), Positives = 261/657 (39%), Gaps = 87/657 (13%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFN---QKRAKFKELYLAKE---EDLKRQN 61
            +Q  + L + VA+LE+  +     Q+Q EQE     +++ + +EL L +E   + L+   
Sbjct: 749  AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL 808

Query: 62   AVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVM 121
             V + AQ+ L      L   +++++   A  +   + +++ +++ +R+ + +V +L+   
Sbjct: 809  RVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAA 868

Query: 122  KETVRDYEHQFHLR------------LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN 169
            +E     +    L             L +E T+    +E+ E  + +++R+L++      
Sbjct: 869  REKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ------ 922

Query: 170  LENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKI---KELEASKVKELNHYLEA 226
            LE   ++ + + + L      +  E+A L+ ++   ++K    KEL A K+      ++A
Sbjct: 923  LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL------VQA 976

Query: 227  EKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQ 286
            E+  +       A L  Q++  +ED ++L++E       LE ER Q              
Sbjct: 977  EREAQ-------ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQ-------------- 1015

Query: 287  FLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDE---------QQRLNKRKDHKK 337
             L+SQ  L R+ + +   L +E+    EE+    QE DE         QQ L+ ++  K 
Sbjct: 1016 -LQSQ--LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKT 1072

Query: 338  ADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM 397
            A  E+ +      A    E   Q  + +   +  R +V++L + L     D  ++ +   
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL----RDLRAQREEAA 1128

Query: 398  FKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASL 457
                    +  +     G  +   L    + ++   L E         D +      A  
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLED------ARDGLRRELLEAQR 1182

Query: 458  GSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLV------- 510
               +   G  + + +   ++    E  +    L    + + SA       R+        
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANED 1242

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
             E +  LL++     G + G         E+     + +  E R Q+K    ML   N +
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK----MLDSENTR 1298

Query: 571  LEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQ 627
            L + + + Q      +++ ++S  +   L  R    E  LE ++Q L  A+R +QEQ
Sbjct: 1299 LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQ 1355



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 207/968 (21%), Positives = 389/968 (40%), Gaps = 188/968 (19%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            QQ +A  EK + +     Q+L Q   + +A  +E   A EEDL+R     +AA  +L   
Sbjct: 953  QQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAE 1012

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVK--RQWREEVASL--------------- 117
            R QL ++Q + E  + +A + E  K+E  +E+   +Q R+E   L               
Sbjct: 1013 RAQL-QSQLQREQEELLARL-EAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070

Query: 118  QAVMKETVRDYEHQFH-LRLEQERTQW-AQYRESAER--------EIADLRRRLSEG--- 164
            +  + E +    H    + LE ER +  AQ R+  +R        E+ DLR +  E    
Sbjct: 1071 KTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAA 1130

Query: 165  ---------QEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKE---- 211
                     ++  +L  +      +AE+LR+ +  +E     L+ +L EA+ K++E    
Sbjct: 1131 HAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEG 1190

Query: 212  --LEASKVKELNHYL-----EAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH 264
              ++  +  EL   L     E E   R++ E+  AV   +   +        KE  +   
Sbjct: 1191 REVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKE--QKLA 1248

Query: 265  LLEQER----QQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKK-- 318
            LLE+ R    ++  +L+   Q+     LE++R L ++++R   +L SE  R   EL +  
Sbjct: 1249 LLEEARTAVGKEAGELRTGLQEVERSRLEARREL-QELRRQMKMLDSENTRLGRELAELQ 1307

Query: 319  -------KDQEDDEQQRLNKRKDHKKADVEEEI---KIPVVCALTQEESSA--------- 359
                   + +++  ++ L  R+   K +   E+   ++ V     QE+            
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL 1367

Query: 360  -----QLSNEEEHLDSTRGSVHSLDA--------GLLLPSGDPFSKS-DNDMFKDGLRRA 405
                     E++ LD  RG    L+A        GL L + +  ++  + ++ +  ++R 
Sbjct: 1368 GSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427

Query: 406  QSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASL-----GSL 460
             +   LG   S   + LG       A             A+   E  ++ S      GS 
Sbjct: 1428 AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS- 1486

Query: 461  QMPSGFMLTK------DQERAIKAMTPEQEETASL------LSSVTQGMESAYVSPSGYR 508
            Q PS    T       D E    A+    +E  S       L + T  +          R
Sbjct: 1487 QPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAER 1546

Query: 509  LVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQ----IQEAETR---------- 554
              + +    LQK V  A ++  RR     + + +L G+Q    +QE   R          
Sbjct: 1547 DSATSRARQLQKAV--AESEEARR-----SVDGRLSGVQAELALQEESVRRSERERRATL 1599

Query: 555  DQVKKLQLM-------LRQANDQLEKTMKDKQELED---FIKQSSEDSSHQISALVLRAQ 604
            DQV  L+         LR + +++ K   ++ +LE     +K+  + S  +   L L+ +
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659

Query: 605  ASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQ 664
            + E  L+  + GLS  +   Q     +   + QV++  V+      +++  +     +++
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE 1719

Query: 665  AEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKA---EILFLKEQIQ-AEQCLK 720
            +E   L D    L E + +    + + R    H+++ L A   +   L+E++  A Q L 
Sbjct: 1720 SEG-ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1778

Query: 721  ENLEETLQL--EIENCKEEIASISSLKAELERIKVE--------------KGQA----TV 760
            E  +++  L  +++  + E+A +     EL+R++ E              +G+A    TV
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADL-----ELQRVEAEGQLQQLREVLRQRQEGEAAALNTV 1833

Query: 761  EQLMFEEKNKAQRL--------QTELDVSE------QVQRDFVKLSQTL-QVQLERIRQA 805
            ++L  E +   +RL        Q E +  E      ++++D V L +TL +V+ E++R  
Sbjct: 1834 QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSH 1893

Query: 806  DSLERIRA 813
            +   R+ A
Sbjct: 1894 EDTVRLSA 1901



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 165/812 (20%), Positives = 305/812 (37%), Gaps = 126/812 (15%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKR----QNAVLQAAQD 69
            L+  + E+E+   E  R  Q+L ++     ++   L     E   R    + A  ++ ++
Sbjct: 1264 LRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRE 1323

Query: 70   DLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYE 129
             LG LR +L + +A +E ++    V++   QE   E + + R  + SL+       +  +
Sbjct: 1324 TLG-LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLD 1382

Query: 130  HQFHLRLEQERTQWAQYRESAEREIADLRRRLS------EGQEEENLENEMKKAQEDAEK 183
            H   L L+ E         +A  E A+L  RLS      +G E E    E+++   +A+ 
Sbjct: 1383 HARGLELKLE---------AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQL 1433

Query: 184  --LRSVVM----------PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCR 231
              LRS +           P  + +     +   AE   + L +    E          C 
Sbjct: 1434 GGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE----------CS 1483

Query: 232  TDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQ 291
               +       T  +    D E +R  L E    L   +++ ++L+      N Q  E  
Sbjct: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE-- 1541

Query: 292  RLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCA 351
                     ME    S   R   +L+K   E +E +R     D + + V+ E+ +     
Sbjct: 1542 ---------MEAERDSATSR-ARQLQKAVAESEEARR---SVDGRLSGVQAELAL----- 1583

Query: 352  LTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSL 411
              QEES  +   E     +T   V +L+  L     +             LR +Q  + +
Sbjct: 1584 --QEESVRRSERERR---ATLDQVATLERSLQATESE-------------LRASQ--EKI 1623

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPL-VGADSVSENFDTASLGSLQMPSGFMLTK 470
                + ++K  G   + K   +  ES    L +   S+      + LG     +     +
Sbjct: 1624 SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ 1683

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
            D+  +++    + E  A  L    + +  A         V E+E  L  K          
Sbjct: 1684 DRVDSLQRQVADSEVKAGTLQLTVERLNGALAK------VEESEGALRDKV--------- 1728

Query: 531  RRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE 590
                      + L     Q + + +  +   L L++A    E   +  QE  D  +Q+  
Sbjct: 1729 ----------RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALS 1778

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
            ++  Q S+L  + Q     + +L+    +A+  +Q+   VL Q +E  +  L  +QK  D
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD 1838

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE-EKLKAEILFL 709
              +       SLQ+A   +  +  E  R   L+  +D + +R   D VE EKL++     
Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERS-ALRLEKDRVALRRTLDKVEREKLRSH---- 1893

Query: 710  KEQIQAEQCLKENLEETL---QLEIENCKEEIASISSLKAELE------RIKVEKGQATV 760
             E        K  L+ TL   +LE+   + +I  + +    LE      +++V+  Q  +
Sbjct: 1894 -EDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952

Query: 761  EQLMFEEKNKAQRLQTE--LDVSEQVQRDFVK 790
            E     E+ ++ + QTE  L+  E+  R  V+
Sbjct: 1953 ELQQEVERLRSAQAQTERTLEARERAHRQRVR 1984



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 62/276 (22%), Positives = 121/276 (43%), Gaps = 41/276 (14%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE--EDLKRQNAVL----QA 66
            +L Q  A L     + L  Q+ L    + ++   + L  A++   + ++Q++ L    Q 
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793

Query: 67   AQDDLGHLRTQLWEAQAEMENIKAIATVSE-------NTKQEAIDEVKRQWREEVASLQA 119
             + ++  L  Q  EA+ +++ ++ +    +       NT Q+  DE +R  +E + SLQ 
Sbjct: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDE-RRLLQERLGSLQR 1852

Query: 120  VMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQE 179
             + +            LE E+ +  +     E++   LRR L      + +E E  ++ E
Sbjct: 1853 ALAQ------------LEAEKREVERSALRLEKDRVALRRTL------DKVEREKLRSHE 1894

Query: 180  DAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVA 239
            D  +L +    +++ +   + +L EA+ +I++LEA  V      LE   S    LE+   
Sbjct: 1895 DTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV-----VLEQSHS-PAQLEVDA- 1947

Query: 240  VLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQ 275
                Q+  LQ++ E+LR    +    LE   + H Q
Sbjct: 1948 --QQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 71/285 (24%), Positives = 124/285 (43%), Gaps = 33/285 (11%)

Query: 551  AETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILL 610
            A+  ++   LQ   RQA  +     ++++ LE+   +          +L +  QA E L 
Sbjct: 760  AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819

Query: 611  EELQQGLSQAKRDVQEQMAVL---MQSREQVSEE-----------LVRLQKDNDSLQGKH 656
            ++L   L   +  +QEQ+A L   +  REQ  E+           L R  ++ ++L  +H
Sbjct: 820  QQLPT-LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEH 878

Query: 657  S-LHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQA 715
            + L V L  AE          L E   + R +   +  +   V+ +L A++   +EQ++A
Sbjct: 879  AGLAVQLVAAE-----REGRTLSEEATRLRLEKEALEGSLFEVQRQL-AQLEARREQLEA 932

Query: 716  EQCLKENLEETLQLEIENCKEEIASI---SSLKAELERIKV----EKGQATVEQLMFEEK 768
            E       +ETL  E+   +++I +    +SL  EL   K+     + QA++ +     +
Sbjct: 933  EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE 992

Query: 769  NKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRA 813
               QRLQ E    E   R+       LQ QL+R  Q + L R+ A
Sbjct: 993  EDLQRLQRE---KEAAWRELEAERAQLQSQLQR-EQEELLARLEA 1033


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1788

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1846

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1900

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2020 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2139 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2190

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2191 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2243

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2364 FQRTLEAERQRQL 2376



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1850

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1905

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1906 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1956

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2017 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2069

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2070 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2182

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2183 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2228 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2462

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLV 2549



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1455 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1506

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1623

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1681

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1682 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1789

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1850 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1965 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2137 KLRKEAEQEAARRAQAE 2153



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2317

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2438 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2488

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2489 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2548 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2601

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2661 AGILSAEEL 2669



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2010

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2179

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2180 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2225

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2286 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2322

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2323 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2364

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2413

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2470

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2531 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2584 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2640

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2641 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2124 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2230

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2231 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2285 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2575 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2624

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2681

Query: 763  LMFEE 767
            L   E
Sbjct: 2682 LARRE 2686



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1083

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1199

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1200 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1253 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1363

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1364 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1422 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1470

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1581

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1582 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1638 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1675

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1792

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1850

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1904

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1963

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2024 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2143 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2194

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2195 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2247

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2368 FQRTLEAERQRQL 2380



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1854

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1909

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1910 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1960

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2020

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2021 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2073

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2074 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2186

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2187 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2231

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2232 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2466

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2467 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLV 2553



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1459 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1510

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1627

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1628 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1685

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1686 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1738

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1793

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1854 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1909 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1968

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1969 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 2023

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 2024 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2141 KLRKEAEQEAARRAQAE 2157



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2321

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2442 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2492

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2493 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2552 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2605

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2606 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2664

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2665 AGILSAEEL 2673



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2014

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2183

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2184 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2229

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2290 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2326

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2327 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2368

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2417

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2474

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2535 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2587

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2588 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2644

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2645 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1888 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2007

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2008 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2067

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2128 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2234

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2235 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2289 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2398

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2579 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2628

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2629 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2685

Query: 763  LMFEE 767
            L   E
Sbjct: 2686 LARRE 2690



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1032 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1087

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1147

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1203

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1204 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1256

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1257 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1311

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1367

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1368 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1425

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1426 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1474

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1534

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1585

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1586 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1642 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1699

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1738


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1788

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1846

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1900

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1959

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2020 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2139 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2190

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2191 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2243

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2364 FQRTLEAERQRQL 2376



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1850

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1905

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1906 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1956

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2017 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2069

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2070 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2182

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2183 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2227

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2228 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2462

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLV 2549



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1455 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1506

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1623

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1624 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1681

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1682 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1789

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1850 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1905 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1965 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 2019

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 2020 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2137 KLRKEAEQEAARRAQAE 2153



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2317

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2438 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2488

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2489 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2548 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2601

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2660

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2661 AGILSAEEL 2669



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2010

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2179

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2180 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2225

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2286 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2322

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2323 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2364

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2413

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2470

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2531 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2583

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2584 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2640

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2641 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2063

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2124 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2230

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2231 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2285 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2394

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2575 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2624

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2625 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2681

Query: 763  LMFEE 767
            L   E
Sbjct: 2682 LARRE 2686



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1028 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1083

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1199

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1200 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1253 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1307

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1363

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1364 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1422 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1470

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1581

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1582 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1638 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1695

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1639

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1756

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1814

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1868

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1927

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 1988 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2107 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2158

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2159 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2211

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2332 FQRTLEAERQRQL 2344



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1818

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1873

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1874 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1924

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1984

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 1985 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2037

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2038 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2150

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2151 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2195

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2196 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2430

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2431 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLV 2517



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1423 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1474

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1591

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1592 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1649

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1650 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1702

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1757

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1818 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1873 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1932

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1933 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 1987

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 1988 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2105 KLRKEAEQEAARRAQAE 2121



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2285

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2406 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2456

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2457 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2516 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2569

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2570 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2628

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2629 AGILSAEEL 2637



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 1978

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2147

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2148 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2193

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2254 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2290

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2291 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2332

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2381

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2438

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2499 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2551

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2552 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2608

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2609 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2639



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1852 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1971

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 1972 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2031

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2092 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2198

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2199 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2253 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2362

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2543 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2592

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2593 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2649

Query: 763  LMFEE 767
            L   E
Sbjct: 2650 LARRE 2654



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 996  KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1051

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1111

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1167

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1168 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1220

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1221 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1275

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1331

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1332 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1390 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1438

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1498

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1549

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1550 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1606 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1663

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1702


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1751 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1808

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1925

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1983

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 2037

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 2096

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2157 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2276 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2327

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2328 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2380

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2501 FQRTLEAERQRQL 2513



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1987

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 2042

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 2043 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 2093

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2153

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2154 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2206

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2207 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2319

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2320 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2364

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2365 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2599

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2600 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLV 2686



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1592 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1643

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1760

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1761 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1818

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1819 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1871

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1926

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1987 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 2101

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 2102 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 2156

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 2157 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2274 KLRKEAEQEAARRAQAE 2290



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2454

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2575 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2625

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2626 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2685 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2738

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2739 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2797

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2798 AGILSAEEL 2806



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2147

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2316

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2317 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2362

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2423 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2459

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2460 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2501

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2550

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2607

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2668 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2720

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2721 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2777

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2778 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 2021 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2140

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2141 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2200

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2261 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2367

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2368 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2422 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2531

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2712 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2761

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2762 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2818

Query: 763  LMFEE 767
            L   E
Sbjct: 2819 LARRE 2823



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1165 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1220

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1280

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1336

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1337 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1390 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1444

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1500

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1501 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1558

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1559 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1607

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1667

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1718

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1719 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1775 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1832

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1871


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1592 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1649

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1766

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1824

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1878

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1937

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 1998 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2117 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2168

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2169 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2221

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2342 FQRTLEAERQRQL 2354



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1828

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1883

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1884 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1934

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 1995 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2047

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2048 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2160

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2161 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2205

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2206 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2440

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2441 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLV 2527



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1433 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1484

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1601

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1602 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1659

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1660 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1712

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1767

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1828 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1883 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1942

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1943 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 1997

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 1998 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2115 KLRKEAEQEAARRAQAE 2131



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2295

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2416 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2466

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2467 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2526 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2579

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2580 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2638

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2639 AGILSAEEL 2647



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 1988

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2157

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2158 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2203

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2264 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2300

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2301 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2342

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2391

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2448

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2509 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2561

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2562 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2618

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2619 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1862 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1981

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 1982 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2041

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2102 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2208

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2209 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2263 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2372

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2553 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2602

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2603 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2659

Query: 763  LMFEE 767
            L   E
Sbjct: 2660 LARRE 2664



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1006 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1061

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1121

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1177

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1178 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1230

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1231 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1285

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1341

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1342 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1399

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1400 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1448

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1508

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1559

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1560 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1616 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1673

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1712


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1600 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1657

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1774

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1832

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1886

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1945

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2006 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2125 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2176

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2177 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2229

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2350 FQRTLEAERQRQL 2362



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1836

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1891

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1892 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1942

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2003 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2055

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2056 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2168

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2169 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2213

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2214 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2448

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2449 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLV 2535



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1441 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1492

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1609

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1610 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1667

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1668 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1720

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1775

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1836 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1891 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1950

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1951 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 2005

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 2006 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2123 KLRKEAEQEAARRAQAE 2139



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2303

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2423

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2424 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2474

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2475 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2534 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2587

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2588 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2646

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2647 AGILSAEEL 2655



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 1996

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2165

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2166 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2211

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2272 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2308

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2309 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2350

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2399

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2456

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2517 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2569

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2570 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2626

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2627 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2657



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1870 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1989

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 1990 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2049

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2110 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2216

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2217 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2271 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2380

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2561 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2610

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2611 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2667

Query: 763  LMFEE 767
            L   E
Sbjct: 2668 LARRE 2672



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1014 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1069

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1129

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1185

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1186 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1238

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1239 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1293

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1349

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1350 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1407

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1408 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1456

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1516

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1567

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1568 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1624 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1681

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1720


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 176/853 (20%), Positives = 357/853 (41%), Gaps = 83/853 (9%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
            Q  V    ++      AQ+  E E   KRA F E     E  L+ ++  +   +++    
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640

Query: 75   RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVA---SLQAVMKETVRDYEHQ 131
              Q  EA+   E  +      +    EA+    R   EEVA   SL     E  ++   +
Sbjct: 1641 AQQQAEAERAREEAERELERWQLKANEALR--LRLQAEEVAQQKSLAQAEAEKQKEEAER 1698

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL--ENEMKKAQEDAEKLRSVVM 189
               R  +   Q  + RE AE+E+ + +R+L+EG  ++ L  E E+ + + + E+      
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757

Query: 190  PMEKEIAALKDKLTEAEDKIKELEA--SKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
             +E+E+A L+ +   A  K +ELEA  +KV+     L A K+ R + E   +     K  
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA-RAEEESR-STSEKSKQR 1815

Query: 248  LQEDAEKLRKELHEVCHL--LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM---- 301
            L+ +A + R+   E   L  L +E ++  QL    + A  Q  E++R+L   +  +    
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEKLAAIGEAT 1873

Query: 302  ------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQE 355
                  EI L  ++       +  + E  +++RL ++    KAD+EE +      A  ++
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL------AQLRK 1927

Query: 356  ESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM----FKDGLRRAQSTDSL 411
             S ++L  ++  ++ T      ++  +L      F K+         + G  R+ + D+L
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTL 1986

Query: 412  GTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKD 471
             +    + +A      A             +  + +  E        +L+         +
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046

Query: 472  QERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRL-VSETEWNLLQ--KEVHNAGNK 528
            + R ++    EQE    L  +     +        +   V + E  L Q  ++  +  ++
Sbjct: 2047 EARRLRERA-EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105

Query: 529  LGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDF 584
            L    +      ++ +  ++Q     A++R QV++ + + + A +Q +   + +   E  
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEEL-- 642
             K++ ++++        RAQA +  L + Q   ++ ++  +     L Q + QV +EL  
Sbjct: 2166 RKEAEQEAAR-------RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ-KAQVEQELTT 2217

Query: 643  VRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKL 702
            +RLQ +    Q K+ L   LQ+    +  + TEA R+   +  E++ +VR   + +  KL
Sbjct: 2218 LRLQLEETDHQ-KNLLDEELQR----LKAEATEAARQR-SQVEEELFSVRVQMEEL-SKL 2270

Query: 703  KAEI------LFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS-------------ISS 743
            KA I      L L+++   ++ L+E  E+  Q+  E  +  +A+             ++ 
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330

Query: 744  LKAELERIKVEKGQATVEQLMFEEKNKAQRLQTEL--DVSEQVQRDFVKLSQTLQVQLER 801
             +A  E++  EK QA  E    + + +  + Q EL  + + ++Q D  +++Q L  + + 
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390

Query: 802  IRQADSLERIRAI 814
             ++    ER R +
Sbjct: 2391 FQRTLEAERQRQL 2403



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 173/867 (19%), Positives = 357/867 (41%), Gaps = 115/867 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            L++ +A L++  A   + +Q+LE E  + RA+ + L  +K    +   +  + ++  L  
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREE---VASLQAVMKETVRDYEH 130
               +  E   E   ++A+A  ++  +Q A ++  RQ  E    +A   A + E  R  + 
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR-LKT 1877

Query: 131  QFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQ----EDAEKLRS 186
            +  + L+++  +  + R  AE E A  RRRL E   +   + E + AQ     D+E    
Sbjct: 1878 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQHKADIEERLAQLRKASDSE---- 1932

Query: 187  VVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKS 246
                +E++   ++D L +     +E+ A K        E   + + +LE+ +  + +   
Sbjct: 1933 ----LERQKGLVEDTLRQRRQVEEEILALKAS-----FEKAAAGKAELELELGRIRSNAE 1983

Query: 247  VLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK---ANDQFLESQRLLMRDMQRMEI 303
                  E+   E      L  +E ++  + +   QK   A ++    ++  + +++R++ 
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2043

Query: 304  VLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ--L 361
             +  E+ R++ E  + +QE   Q +L +    K+   EE+       A+ Q+E   Q  L
Sbjct: 2044 KV--EEARRLRE--RAEQESARQLQLAQEAAQKRLQAEEKAH---AFAVQQKEQELQQTL 2096

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKA 421
              E+  LD  RG   +  A       +              R+ +  + L  S   Q++A
Sbjct: 2097 QQEQSVLDQLRGEAEA--ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154

Query: 422  LGYNYKAKSAGNLD-ESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMT 480
                  A      + E +      A+  +     A+   ++    F      E+ ++   
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA-----EQTLRQKA 2209

Query: 481  PEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYE 540
              ++E  +L   + +               ++ + NLL +E+     +        S  E
Sbjct: 2210 QVEQELTTLRLQLEE---------------TDHQKNLLDEELQRLKAEATEAARQRSQVE 2254

Query: 541  KQLQGIQIQEAETRDQVKKLQLMLRQANDQL-----EKTMKDKQELEDFIKQSSEDSSHQ 595
            ++L  +++Q     +++ KL+  +   N  L     + T +  QE  + +KQ +E+++  
Sbjct: 2255 EELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310

Query: 596  ISALVLRAQASEILLEELQQGLSQAKRDVQEQM-------------AVLMQSREQVSEEL 642
              A    A+  ++  E+L Q  + A++ ++E+M              +L Q +E   E+ 
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370

Query: 643  VRLQKDNDSL--------QG-KHSLHVSLQQ-----AEDFILPDTTEALRELVLKYREDI 688
             RLQ+D + +        QG + +L    Q+     AE   L      +     +  ED 
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLK----------ENLEETLQLEIENCKEEI 738
               R  A+ + EKL    L  +E++   Q L+          E L E +  E+E  KE++
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKL 2489

Query: 739  ---ASISSLKA-ELERIK----VEKGQATVEQLMFEEKNKAQR---LQTELDVSEQVQRD 787
               A +  LK+ E++ ++    +++ QA  +  + E+ +  QR   ++ E    EQ+ +D
Sbjct: 2490 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549

Query: 788  FVKLSQTLQVQLERIRQADSLERIRAI 814
             V  +Q L+ + +R +Q    ER R +
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLV 2576



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 171/857 (19%), Positives = 364/857 (42%), Gaps = 111/857 (12%)

Query: 23   KINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA-------AQDDLGHLR 75
            K  +E LR  ++ E+   Q+RA+ +E     E  L++Q  + +A       A+ +   L+
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS----LQAVMKETVRDYEHQ 131
             ++ E     E     A   + + QE + ++++    E+ +     +A  +  +R  E  
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVM-- 189
              +RL+ E T+  + R  AE E+  LR R  E + ++      ++AQE+AE+LR  V   
Sbjct: 1482 RVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQK------RQAQEEAERLRRQVQDE 1533

Query: 190  -----PMEKEIAA---------------------LKDKLTEAEDKIKELEASKVKELNHY 223
                   E E+A+                     L+ +  EAE ++++ E  + +++   
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593

Query: 224  LE-AEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQK 282
            LE A++S   +L+   A    + + L+     L++E   V  L E+  ++  Q     + 
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAERRAQQQAEAERA 1650

Query: 283  ANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEE 342
              +   E +R  ++  + + + L +E++ Q + L + + E  +++   +R+  ++   EE
Sbjct: 1651 REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA--EREARRRGKAEE 1708

Query: 343  EIKIPVVCALTQEESSAQ-LSNEEEHLDSTRGSVHSLDAGLL-LPSGDPFSKSDNDMFKD 400
            +       A+ Q E + Q L  + +  + T     + +  L+ L +     +    + ++
Sbjct: 1709 Q-------AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1761

Query: 401  GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSL 460
             L R Q   +  T    + +A     +A+      E        A+  S +    S   L
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEM-----EVLLASKARAEEESRSTSEKSKQRL 1816

Query: 461  QMPSG-FMLTKDQERAIKAMTPE-------QEETASLLSSVTQGMESAYVSPSG--YRLV 510
            +  +G F    ++   ++A+  E        EE A+   +  + + +  ++  G   RL 
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E  L +KE  N   +L R   +  +   Q + ++ Q A+ +  +++    LR+A+D 
Sbjct: 1877 TEAEIALKEKEAEN--ERLRR---LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931

Query: 571  --------LEKTMKDKQELED--------FIKQSSEDSSHQISALVLRAQASEILLEELQ 614
                    +E T++ ++++E+        F K ++  +  ++    +R+ A + L  + Q
Sbjct: 1932 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1991

Query: 615  QGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTT 674
              L  A+   Q Q+A   + R + +EE  R+QK   + +       +  +  + +     
Sbjct: 1992 AELEAAR---QRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVERLKAKVE 2046

Query: 675  EALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQ-----L 729
            EA R      +E    ++ A +  +++L+AE    K    A Q  ++ L++TLQ     L
Sbjct: 2047 EARRLRERAEQESARQLQLAQEAAQKRLQAE---EKAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 730  EIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFV 789
            +    + E A  ++ +AE  R++ E+  A   + + E +   Q  + +     Q Q    
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163

Query: 790  KLSQTLQVQLERIRQAD 806
            KL +  + +  R  QA+
Sbjct: 2164 KLRKEAEQEAARRAQAE 2180



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 96/429 (22%), Positives = 193/429 (44%), Gaps = 45/429 (10%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +++++  E  R          Q+ A+ ++L    EEDL +Q A+ +    +   
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAA-----QEAARLRQL---AEEDLAQQRALAEKMLKEKMQ 2344

Query: 74   LRTQLWEAQAEMENI---KAIATVSENTKQEAIDEVKRQWREEVASLQAVMK-ETVRDYE 129
               +    +AE E +   K +A       QE  +++ +Q  EE    Q  ++ E  R  E
Sbjct: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404

Query: 130  -----HQFHLRLEQERTQWAQYRESAER------EIADLRRRLSEGQEE-----ENLENE 173
                  +  LR+ +     A+  E A+R      EI +   R     +E     + LE +
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464

Query: 174  MKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +++  DAE+LR  +  +E+E    K+KL + E K+ +L++ +++     ++ E+  +  
Sbjct: 2465 RQQSDHDAERLREAIAELERE----KEKL-QQEAKLLQLKSEEMQT----VQQEQLLQET 2515

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
              +  + L+ + S+LQ +   + +E  ++  L + E  +  QL+   Q+   Q  + ++ 
Sbjct: 2516 QALQQSFLSEKDSLLQRE-RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574

Query: 294  LMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
            L+  M+         +  + EE  ++ QE + QQ   +R+  ++   EE  ++     L 
Sbjct: 2575 LVASMEE-----ARRRQHEAEEGVRRKQE-ELQQLEQQRRQQEELLAEENQRLREQLQLL 2628

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
            +E+  A L++ EE   S   +  +L  G     G P ++++ +   DGLRR  S   L  
Sbjct: 2629 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDG-PAAEAEPEHSFDGLRRKVSAQRLQE 2687

Query: 414  SGSLQSKAL 422
            +G L ++ L
Sbjct: 2688 AGILSAEEL 2696



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 168/811 (20%), Positives = 312/811 (38%), Gaps = 131/811 (16%)

Query: 11   DVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDD 70
            D    +  AELE      L A+++  +   ++R +     LA EE+  RQ    +AA ++
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKS---LAAEEEAARQR---KAALEE 2037

Query: 71   LGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAV------MKET 124
            +  L+ ++ EA+   E  +  +       QEA    KR   EE A   AV      +++T
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQELQQT 2095

Query: 125  VRDYEHQF-HLRLEQERTQWA-----QYRESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
            ++  +     LR E E  + A     + R  AERE A  RR++ E +  +    E  +A+
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155

Query: 179  EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
              A+     +    ++ AA + +  +A   +++ +A+  +   H   AE++ R       
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQA--ALRQKQAADAEMEKHKKFAEQTLR------- 2206

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                 QK+ ++++   LR +L E  H       Q N L    Q+   +  E+ R   R  
Sbjct: 2207 -----QKAQVEQELTTLRLQLEETDH-------QKNLLDEELQRLKAEATEAAR--QRSQ 2252

Query: 299  QRMEIVLTSEQLRQVEELKKKDQ----------EDDEQQRLNKRKDHKKADVEEEIKIPV 348
               E+     Q+ ++ +LK + +          +D+ Q+ L +  +  K   EE  ++ V
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312

Query: 349  VCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQST 408
                  +E++      EE L   R                        M K+ ++  Q  
Sbjct: 2313 AA----QEAARLRQLAEEDLAQQRALAEK-------------------MLKEKMQAVQEA 2349

Query: 409  DSLGTSGSL--QSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF 466
              L     L  Q K L                      A  + E+ +  +    +   GF
Sbjct: 2350 TRLKAEAELLQQQKELAQEQ------------------ARRLQEDKEQMAQQLAEETQGF 2391

Query: 467  MLTKDQERAIK-AMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNA 525
              T + ER  +  M+ E E     ++ +++    A           E +    +K+    
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA-----------EEDAQRFRKQAEEI 2440

Query: 526  GNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFI 585
            G KL R           +Q ++IQ  ++    ++L+  + +   + EK  ++ + L+   
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--- 2497

Query: 586  KQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQ-------SREQV 638
             +S E  + Q   L+   QA +      +  L Q +R ++++ A L Q         +Q+
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2557

Query: 639  SEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
             EE  R Q+  +  Q +  L  S+++A             E V + +E++  +       
Sbjct: 2558 REEQQRQQQQME--QERQRLVASMEEAR-----RRQHEAEEGVRRKQEELQQLEQQRRQQ 2610

Query: 699  EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
            EE L  E   L+EQ+   Q L+E     L    E    ++A+  +L    + +     +A
Sbjct: 2611 EELLAEENQRLREQL---QLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA 2667

Query: 759  TVEQLM--FEEKNKAQRLQTELDVS-EQVQR 786
              E        K  AQRLQ    +S E++QR
Sbjct: 2668 EPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 164/845 (19%), Positives = 326/845 (38%), Gaps = 126/845 (14%)

Query: 7    ASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQA 66
            A+Q    +++R+A+L K +   L  Q+ L ++  ++R + +E  LA +   ++  A    
Sbjct: 1911 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970

Query: 67   AQDDLGHLRTQLWEA-----QAEMENIKA--IATVSENTKQEAIDEVKRQWR-EEVASLQ 118
             + +LG +R+   +      QAE+E  +   +A   E  ++EA + V++    EE A+ Q
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2030

Query: 119  --AVMKETVRDYEHQFHLRLEQERTQWAQYRE-SAEREIADLRRRLSEGQEEENLENEMK 175
              A ++E  R        R  +ER +    R+    +E A  R +  E      ++ + +
Sbjct: 2031 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ 2090

Query: 176  KAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLE 235
            + Q+  ++ +SV+  +  E  A +    EAE+   + E    +      EAE+  ++  E
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150

Query: 236  MYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM 295
               A     ++  Q  AEKLRKE  +      Q  Q   + K       ++  +     +
Sbjct: 2151 QAQA-----RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205

Query: 296  RDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDH---KKADVEEEIKIPVVCAL 352
            R   ++E  LT+ +L+  E   +K+  D+E QRL         +++ VEEE+        
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-------- 2257

Query: 353  TQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLG 412
                 S ++  EE  L   +  + + +  L+L   D   +   +  +   + A+    L 
Sbjct: 2258 ----FSVRVQMEE--LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311

Query: 413  TSGSLQSKALGYNYKAKSAGNLDESDFGP--LVGADSVSENFDTASLGSLQMPSGFMLTK 470
             +            +A     L E D      +    + E        +       +L +
Sbjct: 2312 VAAQ----------EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361

Query: 471  DQERA---IKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
             +E A    + +  ++E+ A  L+  TQG +    +    +L    E   L+  V     
Sbjct: 2362 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSR 2421

Query: 528  KLGRRCDMCSNYEKQLQGIQIQ----EAETRDQVKKLQLM-------------LRQANDQ 570
               R  +    + KQ + I  +    E  T+++V  +Q +             LR+A  +
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481

Query: 571  LEK--------------------TMKDKQELED--------------------FIKQSSE 590
            LE+                    T++ +Q L++                    FI+Q   
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541

Query: 591  DSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDND 650
                     V +AQ      +  QQ + Q ++ +   M    + + +  E + R Q++  
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601

Query: 651  SLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
             L+ +       ++ ++ +L +  + LRE +    E     R A  H EE   +++   K
Sbjct: 2602 QLEQQ-------RRQQEELLAEENQRLREQLQLLEE---QHRAALAHSEEVTASQVAATK 2651

Query: 711  EQIQAEQCL--------KENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQ 762
                    L         E+  + L+ ++   + + A I S + EL+R+   +G  TV++
Sbjct: 2652 TLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAE-ELQRL--AQGHTTVDE 2708

Query: 763  LMFEE 767
            L   E
Sbjct: 2709 LARRE 2713



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 154/759 (20%), Positives = 302/759 (39%), Gaps = 73/759 (9%)

Query: 80   EAQAEMENI-KAIATVS-ENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR-- 135
            +AQAE+E + K +A +S E  K  A+ E          +L++ ++ T+   E    L   
Sbjct: 1055 KAQAEVEGLGKGVARLSAEAEKVLALPEPS----PAAPTLRSELELTLGKLEQVRSLSAI 1110

Query: 136  -LEQERTQWAQYR--ESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPME 192
             LE+ +T     R  + AE  +     +L E Q       E++  +   +KLR+     +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1170

Query: 193  KEIAALKDKLTEAED---KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
                AL+D+L  A++   ++++    +  E+  + E        LE + AVL  Q  V Q
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL---LERWQAVL-AQTDVRQ 1226

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E+L ++L          R+  + L    Q A  +  + Q + + D Q +   L  EQ
Sbjct: 1227 RELEQLGRQLRYY-------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1279

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLD 369
               +EE+++  ++ +E QR  K+  +   D E    + +V    Q E  A  + + +   
Sbjct: 1280 AL-LEEIERHGEKVEECQRFAKQYINAIKDYE----LQLVTYKAQLEPVASPAKKPKVQS 1334

Query: 370  STRGSVHS-LDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKA 428
             +   +   +D           +        + LRR +  + L      Q +A      A
Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE----QQRAEERERLA 1390

Query: 429  KSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPE---QEE 485
            +    L++     L  A + ++         LQ      + + +E A+ A   +   QEE
Sbjct: 1391 EVEAALEKQR--QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1448

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L  + Q  E+   + +     +E     +++E+     +L          E+Q  G
Sbjct: 1449 ----LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT-------ERQRGG 1497

Query: 546  IQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQA 605
             + +    R + ++ +   RQA ++ E+  +  Q+     +Q+  + + ++ A    A+ 
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1557

Query: 606  SEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQA 665
             +  L+ L++   QA+   +      ++   QV   L   Q+         S    LQ  
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---------SAEAELQSK 1608

Query: 666  EDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---N 722
                   T +  R L    +E+ + V    +  E + + +    + + +AE+ L+     
Sbjct: 1609 RASFAEKTAQLERSL----QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664

Query: 723  LEETLQLEIENCKEEIASISSL-KAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVS 781
              E L+L ++   EE+A   SL +AE E+ K E  +    +   EE+   QR   E ++ 
Sbjct: 1665 ANEALRLRLQ--AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1722

Query: 782  EQVQRDFVKLSQTLQVQLERIR---QADSLERIRAILND 817
            +Q Q       Q L  + E IR   + +  E+ R +L +
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1761


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 157/855 (18%), Positives = 353/855 (41%), Gaps = 94/855 (10%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQ---QQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL    EE+++ + A   
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEEL----EEEIEAERASRA 1134

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R         L ++     + ++  E+E ++++       E ++L + M+   +    
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK------MEIDDLASNMETVSKAKGN 1248

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ +K K  E +  I +L A + +      E  +    + +  V+ L+ 
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL-DEKDTLVSQLSR 1307

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+++L E       + H L+  R   + L+  +++  +   E QR + +
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367

Query: 297  DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEE 356
                +    T  +   +       Q  +E +   K+   +  D EE ++       + E+
Sbjct: 1368 ANSEVAQWRTKYETDAI-------QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420

Query: 357  SSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGS 416
            +  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   +  
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAAL-----DKKQRNFDKILAEWKQKCEETHAELEASQ 1475

Query: 417  LQSKALGYN-YKAKSA--GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQE 473
             +S++L    +K K+A   +LD+ +       +   E  D       Q+  G     + E
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE----QIAEGGKRIHELE 1531

Query: 474  RAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRC 533
            +  K +  E+ E  + L      +E       G  L  + E N ++ EV     +     
Sbjct: 1532 KIKKQVEQEKSELQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKDEEI 1587

Query: 534  D-MCSNYEKQLQGIQIQ-EAETRDQ-------------VKKLQLMLRQANDQLEKTMKDK 578
            D M  N+ + ++ +Q   +AE R +             + ++++ L  AN    + +++ 
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1647

Query: 579  QELEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQM 628
            +  +  +K          +S ED   Q++ +  RA   +  +EEL+  L Q +R      
Sbjct: 1648 RNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER------ 1701

Query: 629  AVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDI 688
                 SR+   +EL+     ++ +Q  H+ + SL   +  +  D ++   E+     EDI
Sbjct: 1702 -----SRKIAEQELL---DASERVQLLHTQNTSLINTKKKLETDISQIQGEM-----EDI 1748

Query: 689  INVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLE---ETLQLEIENCKEEIASISSLK 745
            I     A+   +K   +   + E+++ EQ    +LE   + L+  +++ +  +     L 
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1808

Query: 746  AELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLS-QTLQVQLERIRQ 804
             +  + +++K +A V +L  E +++ +R    +    + +R   +L+ QT + +   +R 
Sbjct: 1809 LKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL 1868

Query: 805  ADSLERIRAILNDTK 819
             D +++++A +   K
Sbjct: 1869 QDLVDKLQAKVKSYK 1883



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 176/837 (21%), Positives = 344/837 (41%), Gaps = 113/837 (13%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLR 75
            +R  + E+INAE    +++LE E ++ +    +L L   +  K ++A     ++      
Sbjct: 928  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN------ 981

Query: 76   TQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLR 135
              L E  A ++   A  T  +   QEA  +     + E   +  + K  ++  +    L 
Sbjct: 982  --LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1039

Query: 136  --LEQERTQWAQYRESAEREIADLRRRLSEGQEEEN----LENEMKKAQEDAEKLRSVVM 189
              LEQE+        +  +   DL+       + EN    L+ ++KK + +   L+S + 
Sbjct: 1040 GSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI- 1098

Query: 190  PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQ 249
               ++  AL  +L   + KIKEL+A +++EL   +EAE++ R   E        Q+S L 
Sbjct: 1099 ---EDEQALGMQL---QKKIKELQA-RIEELEEEIEAERASRAKAE-------KQRSDLS 1144

Query: 250  EDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQ 309
             + E++ + L E       + + +       +K   +F + +R L     + E    + +
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQHEATAATLR 1197

Query: 310  LRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI---------------KIPVVCALTQ 354
             +  + + +  ++ D  QR+ ++ + +K++++ EI                +  +C   +
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257

Query: 355  EESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTS 414
            ++ S ++  +EE        + +  A L   SG+   + D    KD L    S      +
Sbjct: 1258 DQLS-EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE---KDTLVSQLSRGKQAFT 1313

Query: 415  GSLQ--SKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGF------ 466
              ++   + L    KAKSA  L  +        D + E ++       ++          
Sbjct: 1314 QQIEELKRQLEEEIKAKSA--LAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSE 1371

Query: 467  ---MLTKDQERAIKAMTPEQEETASLLSSVTQGMES---------AYVSPSGYRLVSETE 514
                 TK +  AI+  T E EE    L+   Q  E          A +  +  RL +E E
Sbjct: 1372 VAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430

Query: 515  WNLLQKEVHNAG----NKLGRRCD--------MCSNYEKQLQGIQIQEAETRDQVKKLQL 562
              ++  E  NA     +K  R  D         C     +L+  Q +      ++ K++ 
Sbjct: 1431 DLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKN 1490

Query: 563  MLRQANDQLEKTMKD----KQELEDFIKQSSEDSS--HQISALVLRAQAS----EILLEE 612
               ++ DQLE   ++    +QE+ D  +Q +E     H++  +  + +      +  LEE
Sbjct: 1491 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550

Query: 613  LQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQQAEDFILP 671
             +  L   +  +      L Q + +V  ++    ++ D ++  H   V S+Q   D  + 
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIR 1610

Query: 672  DTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---NLEETLQ 728
               +A+R L  K   D+  +    +H   ++ AE L      QA   LK+   +L++ L+
Sbjct: 1611 SRNDAIR-LKKKMEGDLNEMEIQLNHA-NRMAAEALRNYRNTQA--ILKDTQLHLDDALR 1666

Query: 729  LEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQ 785
             + E+ KE++A +   +A L + ++E+ +AT+EQ     K   Q L   LD SE+VQ
Sbjct: 1667 SQ-EDLKEQLAMVER-RANLLQAEIEELRATLEQTERSRKIAEQEL---LDASERVQ 1718



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 172/842 (20%), Positives = 330/842 (39%), Gaps = 131/842 (15%)

Query: 88   IKAIATVSENTKQEA-IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQY 146
            IK +   +E  K+ A + E   + +EE+A  +A  KE       +  + L QE+      
Sbjct: 840  IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKEL-----EEKMVTLMQEKNDLQLQ 894

Query: 147  RESAEREIADLRRRLSEGQEEE-NLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEA 205
             ++    +AD   R  +  + +  LE ++K+  E AE    +   +  +   L+D+ +E 
Sbjct: 895  VQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954

Query: 206  EDKIKELE--ASKVKELNHYLEAEKSCRTD----LEMYVAVLNTQKSVLQEDAE------ 253
            +  I +LE   +KV++  H  E +    T+    L+  +A L  +K  LQE  +      
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014

Query: 254  ---------------KLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
                           KL +++ ++   LEQE++    L+   +K     LE    L ++ 
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRK-----LEGDLKLAQE- 1068

Query: 299  QRMEIVLTSEQLRQVEELKKKDQE--------DDEQ------QRLNKRKDHKKADVEEEI 344
              M+I    +QL   E+LKKK+ E        +DEQ      Q+  K    +  ++EEEI
Sbjct: 1069 STMDIENDKQQLD--EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEI 1126

Query: 345  KIPVVCALTQEESSAQLSNEEEHLD---STRGSVHSLDAGLLLPSGDPFSKSDNDMFKDG 401
            +         E+  + LS E E +       G   S    +       F K   D+ +  
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 402  LRRAQSTDSLGTSGSLQSKALG--YNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGS 459
            L+   +  +L    +     LG   +   +    L++      +  D ++ N +T S   
Sbjct: 1187 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAK 1246

Query: 460  LQMPSGFMLTKDQERAIKAMTPEQ-------------------------EETASLLSSVT 494
              +       +DQ   IK    EQ                         +E  +L+S ++
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306

Query: 495  QGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMC-SNYEKQLQG-IQIQEAE 552
            +G ++        +   E E        H A       CD+    YE++ +   ++Q A 
Sbjct: 1307 RGKQAFTQQIEELKRQLEEEIKAKSALAH-ALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365

Query: 553  TRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEE 612
            ++   +  Q   +   D +++T ++ +E +  + Q  +D+   + A+  +  + E   + 
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQR 1424

Query: 613  LQQ-----------------GLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQG- 654
            LQ                   L + +R+  + +A   Q  E+   EL   QK++ SL   
Sbjct: 1425 LQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTE 1484

Query: 655  ----KHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLK 710
                K++   SL Q E   L    + L++ +    E I        H  EK+K ++   K
Sbjct: 1485 LFKIKNAYEESLDQLE--TLKRENKNLQQEISDLTEQIAEGGKRI-HELEKIKKQVEQEK 1541

Query: 711  EQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNK 770
             ++QA     E  E +L+ E          ++ +K+E++R K+ +    ++Q+       
Sbjct: 1542 SELQA---ALEEAEASLEHEEGKILRIQLELNQVKSEVDR-KIAEKDEEIDQMKRNHIRI 1597

Query: 771  AQRLQTELDVSEQVQRDFVKLSQTLQVQLERIR---------QADSLERIR---AILNDT 818
             + +Q+ LD   + + D ++L + ++  L  +           A++L   R   AIL DT
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657

Query: 819  KL 820
            +L
Sbjct: 1658 QL 1659



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 94/422 (22%), Positives = 174/422 (41%), Gaps = 63/422 (14%)

Query: 15   QQRVAELEKINAEFLRAQQQ---LEQEFNQKRAKFKELYLAK---EEDLKRQNAVLQAAQ 68
            ++ + +LE +  E    QQ+   L ++  +   +  EL   K   E++     A L+ A+
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAE 1552

Query: 69   DDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDY 128
              L H   ++   Q E+  +K+        K E ID++KR     V S+Q+ +   +R  
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSR 1612

Query: 129  EHQFHL--RLEQERTQWAQYRESAEREIADLRRRLSEGQ-----EEENLENEMKKAQEDA 181
                 L  ++E +  +       A R  A+  R     Q      + +L++ ++  ++  
Sbjct: 1613 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLK 1672

Query: 182  EKLRSV---VMPMEKEIAALKDKL--TEAEDKIKE---LEASKVKELNH-----YLEAEK 228
            E+L  V      ++ EI  L+  L  TE   KI E   L+AS+  +L H      +  +K
Sbjct: 1673 EQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1732

Query: 229  SCRTDLEMYVAVLNTQKSVLQED-----------------AEKLRKELHEVCHLLEQER- 270
               TD+     +    + ++QE                  AE+L+KE     HL   ++ 
Sbjct: 1733 KLETDISQ---IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 271  --QQHNQLKHTWQKANDQFLES-----QRLLMRDMQRMEIVLTSEQLRQVEELK------ 317
              Q    L+H   +A    L+      Q+L  R ++ +E  + SEQ R VE +K      
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR-VRELEGEVESEQKRNVEAVKGLRKHE 1848

Query: 318  KKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHS 377
            +K +E   Q   +++   +  D+ ++++  V     Q E + + SN   +L   R   H 
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN--VNLSKFRRIQHE 1906

Query: 378  LD 379
            L+
Sbjct: 1907 LE 1908



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/305 (16%), Positives = 135/305 (44%), Gaps = 30/305 (9%)

Query: 548  IQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED---FIKQSSEDSSHQISA------ 598
            ++ AET  ++  ++    +  ++L KT   ++ELE+    + Q   D   Q+ A      
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903

Query: 599  -------------LVLRAQASEIL-----LEELQQGLSQAKRDVQEQMAVLMQSREQVSE 640
                         + L A+  E+       EE+   L+  KR ++++ + L +  + +  
Sbjct: 904  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963

Query: 641  ELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEE 700
             L +++K+  + + K           D  +   T+  + L   +++ + +++   D V  
Sbjct: 964  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023

Query: 701  KLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATV 760
              KA+I   ++    E  L++  E+ +++++E  K ++     L A+   + +E  +  +
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQ--EKKIRMDLERAKRKLEGDLKL-AQESTMDIENDKQQL 1080

Query: 761  EQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKL 820
            ++ + +++ +   LQ++++  + +     K  + LQ ++E + +    ER      + + 
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140

Query: 821  TDINQ 825
            +D+++
Sbjct: 1141 SDLSR 1145



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 57/251 (22%), Positives = 102/251 (40%), Gaps = 29/251 (11%)

Query: 559  KLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLS 618
            K++ +L+ A  + EK M + +E  +F K   E         + + +A    LEE    L 
Sbjct: 839  KIKPLLKSA--ETEKEMANMKE--EFEKTKEE---------LAKTEAKRKELEEKMVTLM 885

Query: 619  QAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALR 678
            Q K D+Q Q+     S     E   +L K    L+ K        + E+ I  + T   R
Sbjct: 886  QEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR 945

Query: 679  ELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEI 738
            +L     ++   ++   D +E  L         +++ E+   EN  + L  E+    E I
Sbjct: 946  KL----EDECSELKKDIDDLELTL--------AKVEKEKHATENKVKNLTEEMAGLDETI 993

Query: 739  ASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQ 798
            A ++  K  L+    E  Q T++ L  EE       + ++ + +QV      L Q  +++
Sbjct: 994  AKLTKEKKALQ----EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIR 1049

Query: 799  LERIRQADSLE 809
            ++  R    LE
Sbjct: 1050 MDLERAKRKLE 1060


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 178/845 (21%), Positives = 353/845 (41%), Gaps = 129/845 (15%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFK--ELYLAKEEDLKR--QNAVLQAAQDDL 71
            +R  + E+INAE    +++LE E ++ +      EL LAK E  K   +N V    ++  
Sbjct: 930  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989

Query: 72   GHLRT---------QLWEA-QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVM 121
            G   T          L EA Q  +++++A     E  K   + + K +  ++V  L+  +
Sbjct: 990  GLDETIAKLTKEKKALQEAHQQTLDDLQA-----EEDKVNTLTKAKIKLEQQVDDLEGSL 1044

Query: 122  KETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA 181
            ++     E +  + LE+ + +     + A+  I D+        E++ L+ ++KK + + 
Sbjct: 1045 EQ-----EKKLRMDLERAKRKLEGDLKLAQESIMDIEN------EKQQLDEKLKKKEFEI 1093

Query: 182  EKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVL 241
              L+S +    ++  AL  +L   + KIKEL+A +++EL   +EAE++ R   E      
Sbjct: 1094 SNLQSKI----EDEQALGIQL---QKKIKELQA-RIEELEEEIEAERASRAKAE------ 1139

Query: 242  NTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM 301
              Q+S L  + E++ + L E       + + +       +K   +F + +R L     + 
Sbjct: 1140 -KQRSDLSRELEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQH 1191

Query: 302  EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI---------------KI 346
            E    + + +  + + +  ++ D  QR+ ++ + +K++++ EI                +
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251

Query: 347  PVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDA--GLLLPSGDPFSKSDNDMFKDGLRR 404
              +C   +++ S   S EEE     +  ++ L A  G L      FS+  ++  K+ L  
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEFSRQLDE--KEALVS 1305

Query: 405  AQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS 464
              S      +  ++        + K+   L  +        D + E ++       ++  
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 465  GF---------MLTKDQERAIKAMTPEQEETASLLSSVTQGMES---------AYVSPSG 506
                         TK +  AI+  T E EE    L+   Q  E          A +  + 
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 507  YRLVSETEWNLLQKEVHNAG----NKLGRRCD--------MCSNYEKQLQGIQIQEAETR 554
             RL +E E  +L  E  NA     +K  R  D         C     +L+  Q +     
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 555  DQVKKLQLMLRQANDQLEKTMKD----KQELEDFIKQSSEDSS--HQISALVLRAQAS-- 606
             ++ K++    ++ DQLE   ++    +QE+ D  +Q +E     H++  +  + +    
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 607  --EILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQ 663
              +  LEE +  L   +  +      L Q + +V  ++    ++ D L+  H   V S+Q
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE-- 721
               D  +    +A+R L  K   D+  +    +H   ++ AE   L+     +  LK+  
Sbjct: 1605 STLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHA-NRMAAEA--LRNYRNTQGILKDTQ 1660

Query: 722  -NLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDV 780
             +L++ L+ + E+ KE++A +   +A L + ++E+ +AT+EQ     K   Q L   LD 
Sbjct: 1661 IHLDDALRSQ-EDLKEQLAMVER-RANLLQAEIEELRATLEQTERSRKIAEQEL---LDA 1715

Query: 781  SEQVQ 785
            SE+VQ
Sbjct: 1716 SERVQ 1720



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 159/822 (19%), Positives = 337/822 (40%), Gaps = 90/822 (10%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQ---QLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL    EE+++ + A   
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL----EEEIEAERASRA 1136

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R         L ++     + ++  E+E ++++       E ++L + ++   +    
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK------MEIDDLASNVETVSKAKGN 1250

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ LK K  E +  I +L A + +      E  +    + E  V+ L+ 
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL-DEKEALVSQLSR 1309

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+++L E       + H L+  R   + L+  +++  +   E QR L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 297  ---DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
               ++ +      ++ +++ EEL++  ++    QRL   ++H +A       +   CA +
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKK--LAQRLQAAEEHVEA-------VNAKCA-S 1419

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
             E++  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAAL-----DKKQRNFDKILAEWKQKCEETHAELE 1474

Query: 414  SGSLQSKALGYN-YKAKSA--GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK 470
            +   ++++LG   +K K+A   +LD+ +       +   E  D       Q+  G     
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE----QIAEGGKRIH 1530

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
            + E+  K +  E+ E  + L      +E       G  L  + E N ++ EV     +  
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKD 1586

Query: 531  RRCDMCS-NYEKQLQGIQIQ-EAETRDQ-------------VKKLQLMLRQANDQLEKTM 575
               D    N+ + ++ +Q   +AE R +             + ++++ L  AN    + +
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 576  KDKQELEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQ 625
            ++ +  +  +K          +S ED   Q++ +  RA   +  +EEL+  L Q +R   
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER--- 1703

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKY 684
                +  Q     SE +  L   N SL   K  L   + Q +   + D  +  R    K 
Sbjct: 1704 -SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG-EMEDILQEARNAEEKA 1761

Query: 685  REDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---NLEETLQLEIENCKEEI--- 738
            ++ I +    A+ ++++        + +   EQ +K+    L+E  QL ++  K++I   
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821

Query: 739  -ASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELD 779
             A +  L+ E+E  +    +A       E + K    QTE D
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEED 1863



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 154/788 (19%), Positives = 315/788 (39%), Gaps = 114/788 (14%)

Query: 57   LKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA-IDEVKRQWREEVA 115
            ++R+ A+     +    +  + W        IK +   +E  K+ A + E  ++ ++E+A
Sbjct: 811  VERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA 870

Query: 116  SLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE-NLENEM 174
              +A  KE     E +    L+++     Q +  AE  +AD   R  +  + +  LE ++
Sbjct: 871  KSEAKRKEL----EEKMVTLLKEKNDLQLQVQAEAEG-LADAEERCDQLIKTKIQLEAKI 925

Query: 175  KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAEKSCRT 232
            K+  E AE    +   +  +   L+D+ +E +  I +LE   +KV++  H  E +    T
Sbjct: 926  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 985

Query: 233  D----LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF- 287
            +    L+  +A L  +K  LQE  ++   +       L+ E  + N L     K   Q  
Sbjct: 986  EEMAGLDETIAKLTKEKKALQEAHQQTLDD-------LQAEEDKVNTLTKAKIKLEQQVD 1038

Query: 288  -----LESQRLLMRDMQRM------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHK 336
                 LE ++ L  D++R       ++ L  E +  +E   +K Q D++ ++      + 
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE--NEKQQLDEKLKKKEFEISNL 1096

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDND 396
            ++ +E+E  + +      +E  A++   EE +++ R S    +            K  +D
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE------------KQRSD 1144

Query: 397  MFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTAS 456
            + ++     + ++ L  +G   S  +  N K        E++F        +  + + A+
Sbjct: 1145 LSRE---LEEISERLEEAGGATSAQIEMNKKR-------EAEF------QKMRRDLEEAT 1188

Query: 457  LGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWN 516
            L               E     +  +  ++ + L      ++         +   + E +
Sbjct: 1189 L-------------QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMK 576
             L   V       G    MC   E QL  ++ +E E +          R  ND   +  +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ----------RLINDLTAQRGR 1285

Query: 577  DKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSRE 636
             + E  +F +Q  E  +  +S L    QA    +EEL++ L +  +        L  SR 
Sbjct: 1286 LQTESGEFSRQLDEKEA-LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 637  QVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAAD 696
                +L+R Q + +  + K  L  +L +A   +    T        KY  D I      +
Sbjct: 1345 DC--DLLREQYEEEQ-ESKAELQRALSKANTEVAQWRT--------KYETDAIQRTEELE 1393

Query: 697  HVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCKEEIASISSLKAELERIKV 753
              ++KL   +   +E ++A      +LE+T   LQ E+E+   ++   ++  A L     
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL----- 1448

Query: 754  EKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA--DSLERI 811
            +K Q   ++++ E K K +    EL+ S+       K +++L  +L +I+ A  +SL+++
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQ-------KEARSLGTELFKIKNAYEESLDQL 1501

Query: 812  RAILNDTK 819
              +  + K
Sbjct: 1502 ETLKRENK 1509



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 71/346 (20%), Positives = 166/346 (47%), Gaps = 43/346 (12%)

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E   +++E     ++L +        E+++  +  ++ + + QV+     L  A ++
Sbjct: 851  TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEER 910

Query: 571  LEKTMKDKQELEDFIKQSSE--DSSHQISALV------LRAQASEIL--LEELQQGLSQA 620
             ++ +K K +LE  IK+ +E  +   +I+A +      L  + SE+   +++L+  L++ 
Sbjct: 911  CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 970

Query: 621  KRD---VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEAL 677
            +++    + ++  L +    + E + +L K+  +LQ  H   +   QAE+    D    L
Sbjct: 971  EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE----DKVNTL 1026

Query: 678  RELVLKYREDIIN----------VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETL 727
             +  +K  + + +          +R   +  + KL+ ++   +E I   +  K+ L+E L
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086

Query: 728  ---QLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFE-EKNKAQRLQTELDVSEQ 783
               + EI N + +I    +L  +L++ K+++ QA +E+L  E E  +A R + E   S+ 
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQK-KIKELQARIEELEEEIEAERASRAKAEKQRSD- 1144

Query: 784  VQRDFVKLSQTL---------QVQLERIRQADSLERIRAILNDTKL 820
            + R+  ++S+ L         Q+++ + R+A+  +++R  L +  L
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATL 1189



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 48/299 (16%), Positives = 142/299 (47%), Gaps = 16/299 (5%)

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE---DSSHQI 596
            EK++  ++ +  + +D++ K +   ++  +++   +K+K +L+  ++  +E   D+  + 
Sbjct: 852  EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERC 911

Query: 597  SALV-----LRAQASEIL-----LEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQ 646
              L+     L A+  E+       EE+   L+  KR ++++ + L +  + +   L +++
Sbjct: 912  DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971

Query: 647  KDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEI 706
            K+  + + K           D  +   T+  + L   +++ + +++   D V    KA+I
Sbjct: 972  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1031

Query: 707  LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFE 766
               ++    E  L++  E+ L++++E  K ++     L A+   + +E  +  +++ + +
Sbjct: 1032 KLEQQVDDLEGSLEQ--EKKLRMDLERAKRKLEGDLKL-AQESIMDIENEKQQLDEKLKK 1088

Query: 767  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQ 825
            ++ +   LQ++++  + +     K  + LQ ++E + +    ER      + + +D+++
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1147


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 178/845 (21%), Positives = 353/845 (41%), Gaps = 129/845 (15%)

Query: 16   QRVAELEKINAEFLRAQQQLEQEFNQKRAKFK--ELYLAKEEDLKR--QNAVLQAAQDDL 71
            +R  + E+INAE    +++LE E ++ +      EL LAK E  K   +N V    ++  
Sbjct: 930  ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989

Query: 72   GHLRT---------QLWEA-QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVM 121
            G   T          L EA Q  +++++A     E  K   + + K +  ++V  L+  +
Sbjct: 990  GLDETIAKLTKEKKALQEAHQQTLDDLQA-----EEDKVNTLTKAKIKLEQQVDDLEGSL 1044

Query: 122  KETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA 181
            ++     E +  + LE+ + +     + A+  I D+        E++ L+ ++KK + + 
Sbjct: 1045 EQ-----EKKLRMDLERAKRKLEGDLKLAQESIMDIEN------EKQQLDEKLKKKEFEI 1093

Query: 182  EKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVL 241
              L+S +    ++  AL  +L   + KIKEL+A +++EL   +EAE++ R   E      
Sbjct: 1094 SNLQSKI----EDEQALGIQL---QKKIKELQA-RIEELEEEIEAERASRAKAE------ 1139

Query: 242  NTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM 301
              Q+S L  + E++ + L E       + + +       +K   +F + +R L     + 
Sbjct: 1140 -KQRSDLSRELEEISERLEEAGGATSAQIEMN-------KKREAEFQKMRRDLEEATLQH 1191

Query: 302  EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEI---------------KI 346
            E    + + +  + + +  ++ D  QR+ ++ + +K++++ EI                +
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251

Query: 347  PVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDA--GLLLPSGDPFSKSDNDMFKDGLRR 404
              +C   +++ S   S EEE     +  ++ L A  G L      FS+  ++  K+ L  
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEFSRQLDE--KEALVS 1305

Query: 405  AQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPS 464
              S      +  ++        + K+   L  +        D + E ++       ++  
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365

Query: 465  GF---------MLTKDQERAIKAMTPEQEETASLLSSVTQGMES---------AYVSPSG 506
                         TK +  AI+  T E EE    L+   Q  E          A +  + 
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 507  YRLVSETEWNLLQKEVHNAG----NKLGRRCD--------MCSNYEKQLQGIQIQEAETR 554
             RL +E E  +L  E  NA     +K  R  D         C     +L+  Q +     
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484

Query: 555  DQVKKLQLMLRQANDQLEKTMKD----KQELEDFIKQSSEDSS--HQISALVLRAQAS-- 606
             ++ K++    ++ DQLE   ++    +QE+ D  +Q +E     H++  +  + +    
Sbjct: 1485 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 607  --EILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV-SLQ 663
              +  LEE +  L   +  +      L Q + +V  ++    ++ D L+  H   V S+Q
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604

Query: 664  QAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE-- 721
               D  +    +A+R L  K   D+  +    +H   ++ AE   L+     +  LK+  
Sbjct: 1605 STLDAEIRSRNDAIR-LKKKMEGDLNEMEIQLNHA-NRMAAEA--LRNYRNTQGILKDTQ 1660

Query: 722  -NLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDV 780
             +L++ L+ + E+ KE++A +   +A L + ++E+ +AT+EQ     K   Q L   LD 
Sbjct: 1661 IHLDDALRSQ-EDLKEQLAMVER-RANLLQAEIEELRATLEQTERSRKIAEQEL---LDA 1715

Query: 781  SEQVQ 785
            SE+VQ
Sbjct: 1716 SERVQ 1720



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 159/822 (19%), Positives = 337/822 (40%), Gaps = 90/822 (10%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQ---QLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQ 65
            Q D  L+++  E+  + ++    Q    QL+++  + +A+ +EL    EE+++ + A   
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL----EEEIEAERASRA 1136

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAI--ATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
             A+     L  +L E    +E       A +  N K+EA  +  R+  EE          
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
            T+R         L ++     + ++  E+E ++++       E ++L + ++   +    
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK------MEIDDLASNVETVSKAKGN 1250

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
            L  +   +E +++ LK K  E +  I +L A + +      E  +    + E  V+ L+ 
Sbjct: 1251 LEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQL-DEKEALVSQLSR 1309

Query: 244  QKSVLQEDAEKLRKELHE-------VCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMR 296
             K    +  E+L+++L E       + H L+  R   + L+  +++  +   E QR L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 297  ---DMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALT 353
               ++ +      ++ +++ EEL++  ++    QRL   ++H +A       +   CA +
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKK--LAQRLQAAEEHVEA-------VNAKCA-S 1419

Query: 354  QEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGT 413
             E++  +L NE E L       ++  A L     D   ++ + +  +  ++ + T +   
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAAL-----DKKQRNFDKILAEWKQKCEETHAELE 1474

Query: 414  SGSLQSKALGYN-YKAKSA--GNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK 470
            +   ++++LG   +K K+A   +LD+ +       +   E  D       Q+  G     
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE----QIAEGGKRIH 1530

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
            + E+  K +  E+ E  + L      +E       G  L  + E N ++ EV     +  
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHE----EGKILRIQLELNQVKSEVDRKIAEKD 1586

Query: 531  RRCDMCS-NYEKQLQGIQIQ-EAETRDQ-------------VKKLQLMLRQANDQLEKTM 575
               D    N+ + ++ +Q   +AE R +             + ++++ L  AN    + +
Sbjct: 1587 EEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646

Query: 576  KDKQELEDFIK----------QSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQ 625
            ++ +  +  +K          +S ED   Q++ +  RA   +  +EEL+  L Q +R   
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER--- 1703

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSL-QGKHSLHVSLQQAEDFILPDTTEALRELVLKY 684
                +  Q     SE +  L   N SL   K  L   + Q +   + D  +  R    K 
Sbjct: 1704 -SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG-EMEDILQEARNAEEKA 1761

Query: 685  REDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKE---NLEETLQLEIENCKEEI--- 738
            ++ I +    A+ ++++        + +   EQ +K+    L+E  QL ++  K++I   
Sbjct: 1762 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKL 1821

Query: 739  -ASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELD 779
             A +  L+ E+E  +    +A       E + K    QTE D
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEED 1863



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 154/788 (19%), Positives = 315/788 (39%), Gaps = 114/788 (14%)

Query: 57   LKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA-IDEVKRQWREEVA 115
            ++R+ A+     +    +  + W        IK +   +E  K+ A + E  ++ ++E+A
Sbjct: 811  VERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELA 870

Query: 116  SLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEE-NLENEM 174
              +A  KE     E +    L+++     Q +  AE  +AD   R  +  + +  LE ++
Sbjct: 871  KSEAKRKEL----EEKMVTLLKEKNDLQLQVQAEAEG-LADAEERCDQLIKTKIQLEAKI 925

Query: 175  KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELE--ASKVKELNHYLEAEKSCRT 232
            K+  E AE    +   +  +   L+D+ +E +  I +LE   +KV++  H  E +    T
Sbjct: 926  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 985

Query: 233  D----LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF- 287
            +    L+  +A L  +K  LQE  ++   +       L+ E  + N L     K   Q  
Sbjct: 986  EEMAGLDETIAKLTKEKKALQEAHQQTLDD-------LQAEEDKVNTLTKAKIKLEQQVD 1038

Query: 288  -----LESQRLLMRDMQRM------EIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHK 336
                 LE ++ L  D++R       ++ L  E +  +E   +K Q D++ ++      + 
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE--NEKQQLDEKLKKKEFEISNL 1096

Query: 337  KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDND 396
            ++ +E+E  + +      +E  A++   EE +++ R S    +            K  +D
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE------------KQRSD 1144

Query: 397  MFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTAS 456
            + ++     + ++ L  +G   S  +  N K        E++F        +  + + A+
Sbjct: 1145 LSRE---LEEISERLEEAGGATSAQIEMNKKR-------EAEF------QKMRRDLEEAT 1188

Query: 457  LGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWN 516
            L               E     +  +  ++ + L      ++         +   + E +
Sbjct: 1189 L-------------QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMK 576
             L   V       G    MC   E QL  ++ +E E +          R  ND   +  +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ----------RLINDLTAQRGR 1285

Query: 577  DKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSRE 636
             + E  +F +Q  E  +  +S L    QA    +EEL++ L +  +        L  SR 
Sbjct: 1286 LQTESGEFSRQLDEKEA-LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRH 1344

Query: 637  QVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAAD 696
                +L+R Q + +  + K  L  +L +A   +    T        KY  D I      +
Sbjct: 1345 DC--DLLREQYEEEQ-ESKAELQRALSKANTEVAQWRT--------KYETDAIQRTEELE 1393

Query: 697  HVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCKEEIASISSLKAELERIKV 753
              ++KL   +   +E ++A      +LE+T   LQ E+E+   ++   ++  A L     
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL----- 1448

Query: 754  EKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQA--DSLERI 811
            +K Q   ++++ E K K +    EL+ S+       K +++L  +L +I+ A  +SL+++
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQ-------KEARSLGTELFKIKNAYEESLDQL 1501

Query: 812  RAILNDTK 819
              +  + K
Sbjct: 1502 ETLKRENK 1509



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 71/346 (20%), Positives = 166/346 (47%), Gaps = 43/346 (12%)

Query: 511  SETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
            +E E   +++E     ++L +        E+++  +  ++ + + QV+     L  A ++
Sbjct: 851  TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEER 910

Query: 571  LEKTMKDKQELEDFIKQSSE--DSSHQISALV------LRAQASEIL--LEELQQGLSQA 620
             ++ +K K +LE  IK+ +E  +   +I+A +      L  + SE+   +++L+  L++ 
Sbjct: 911  CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 970

Query: 621  KRD---VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEAL 677
            +++    + ++  L +    + E + +L K+  +LQ  H   +   QAE+    D    L
Sbjct: 971  EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE----DKVNTL 1026

Query: 678  RELVLKYREDIIN----------VRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETL 727
             +  +K  + + +          +R   +  + KL+ ++   +E I   +  K+ L+E L
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKL 1086

Query: 728  ---QLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFE-EKNKAQRLQTELDVSEQ 783
               + EI N + +I    +L  +L++ K+++ QA +E+L  E E  +A R + E   S+ 
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQK-KIKELQARIEELEEEIEAERASRAKAEKQRSD- 1144

Query: 784  VQRDFVKLSQTL---------QVQLERIRQADSLERIRAILNDTKL 820
            + R+  ++S+ L         Q+++ + R+A+  +++R  L +  L
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATL 1189



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 48/299 (16%), Positives = 142/299 (47%), Gaps = 16/299 (5%)

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSE---DSSHQI 596
            EK++  ++ +  + +D++ K +   ++  +++   +K+K +L+  ++  +E   D+  + 
Sbjct: 852  EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERC 911

Query: 597  SALV-----LRAQASEIL-----LEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQ 646
              L+     L A+  E+       EE+   L+  KR ++++ + L +  + +   L +++
Sbjct: 912  DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 971

Query: 647  KDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEI 706
            K+  + + K           D  +   T+  + L   +++ + +++   D V    KA+I
Sbjct: 972  KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1031

Query: 707  LFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFE 766
               ++    E  L++  E+ L++++E  K ++     L A+   + +E  +  +++ + +
Sbjct: 1032 KLEQQVDDLEGSLEQ--EKKLRMDLERAKRKLEGDLKL-AQESIMDIENEKQQLDEKLKK 1088

Query: 767  EKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQ 825
            ++ +   LQ++++  + +     K  + LQ ++E + +    ER      + + +D+++
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1147


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 182/876 (20%), Positives = 349/876 (39%), Gaps = 100/876 (11%)

Query: 9    QPDVSLQQRVAELEKINAEF----------LRAQQQLEQEFNQKRAKFKELYLAKEEDLK 58
            +  ++ + R+ E+E + ++           L+A+ +L  E  + RA+        EE   
Sbjct: 859  EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918

Query: 59   RQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQ-----EAIDEVK-RQWRE 112
               A ++  ++   HL+ +  + Q  ++ ++      E+ +Q     +   E K ++  E
Sbjct: 919  DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978

Query: 113  EVASLQ------AVMKETVRDYEHQFHLRL---EQERTQWAQYRESAEREIADLRRRL-S 162
            E   L+      A  K+ + D   +F   L   E++    A+ +   E  I DL  RL  
Sbjct: 979  EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038

Query: 163  EGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAED--------------- 207
            E ++ + LE   +K + D+  L   +  ++ +IA LK +L + E+               
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098

Query: 208  ------KIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHE 261
                  KI+ELE S++ EL   LE+E++ R   E        QK  L E+ E L+ EL +
Sbjct: 1099 KNMALKKIRELE-SQISELQEDLESERASRNKAE-------KQKRDLGEELEALKTELED 1150

Query: 262  VC-------HLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVE 314
                      L  +  Q+ N LK T ++   +  E+Q   MR      +   +EQL Q +
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209

Query: 315  ELK------KKDQEDDEQQRLNKRK---------DHKKADVEEEIKIPVVCALTQEESSA 359
             +K      K+  E++  +  N+ K         +HK+  VE +++   V     E    
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT 1269

Query: 360  QLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQS 419
            +L+++   L     +V     GLL  S    SK   D F     + Q T  L    + Q 
Sbjct: 1270 ELADKVTKLQVELDNV----TGLLSQSDSKSSKLTKD-FSALESQLQDTQELLQEENRQK 1324

Query: 420  KALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAM 479
              L  + K K   +   S    L   +    N +   + +L      M  K  E ++  +
Sbjct: 1325 --LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE-KQIATLHAQVADM-KKKMEDSVGCL 1380

Query: 480  TPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNY 539
               +E    L   +    +      + Y  + +T+   LQ+E+ +    L  +     N 
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTK-TRLQQELDDLLVDLDHQRQSACNL 1439

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL 599
            EK+ +      AE     K +     +  D+ E   ++K+     + ++ E++  Q + L
Sbjct: 1440 EKKQKKFDQLLAEE----KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL 1495

Query: 600  VLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQ----GK 655
                +     +E+L        + V E         +QV E   +L++  D LQ     K
Sbjct: 1496 ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK 1555

Query: 656  HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQA 715
              L V+LQ  +     D      +   K ++ +  VR     +E++ K   + +  + + 
Sbjct: 1556 LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615

Query: 716  EQCLKENLEETLQLEIENCKEEIASISSLKAELERI--KVEKGQATVEQLMFEEKNKAQR 773
            E  LK+ LE  +    +N  E I  +  L+A+++    +++  +A+ E+++ + K   ++
Sbjct: 1616 EMDLKD-LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674

Query: 774  LQTELDVSEQVQRDFVKLSQT-LQVQLERIRQADSL 808
            L++      Q+Q +     +   Q Q ER   AD +
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 184/855 (21%), Positives = 360/855 (42%), Gaps = 160/855 (18%)

Query: 14   LQQRVAELEKINAEFLRAQQQLE----------QEFNQKRAKFKELYLAKEEDLKRQNAV 63
            L++R+   EK   E  + +++LE           E   + A+ K     KEE+L+   A 
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091

Query: 64   LQ--AAQDDLG-----HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVAS 116
            ++  AAQ ++       L +Q+ E Q ++E        SE   +   ++ KR   EE+ +
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLE--------SERASRNKAEKQKRDLGEELEA 1143

Query: 117  LQAVMKETVRDYEHQFHLRLEQE------RTQWAQYRESAEREIADLRRRLSEGQEE--E 168
            L+  +++T+     Q  LR ++E      +    +  ++ E +I ++R++ S+  EE  E
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203

Query: 169  NLENEMKKAQEDAEKLRSVVM----PMEKEIAALKDKLTEAEDKIKELEASKVKELNHYL 224
             LE + K+ + + EK +  +      +  E+  L     ++E K K++EA +++EL    
Sbjct: 1204 QLE-QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA-QLQELQVKF 1261

Query: 225  EAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKAN 284
               +  RT+L               +   KL+ EL  V  LL Q   + ++L   +    
Sbjct: 1262 NEGERVRTELA--------------DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307

Query: 285  DQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKK------- 337
             Q  ++Q LL  +  R ++ L S +L+QVE+ K   +E  E++   K    K+       
Sbjct: 1308 SQLQDTQELLQEE-NRQKLSL-STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365

Query: 338  -ADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDND 396
             AD++++++  V C  T EE   +L  + E L               + + D   K+   
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEK--------VAAYDKLEKTKT- 1416

Query: 397  MFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTAS 456
                  R  Q  D L          +  +++ +SA NL++             + FD   
Sbjct: 1417 ------RLQQELDDL---------LVDLDHQRQSACNLEKKQ-----------KKFDQLL 1450

Query: 457  LGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMES-AYVSPSGYRLVSETEW 515
                 + + +   ++++RA      ++ +  SL  ++ + ME  A +     +  +E E 
Sbjct: 1451 AEEKTISAKY--AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED 1508

Query: 516  NLLQKE-----VHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQ 570
             +  K+     VH                + QL+ ++ +   T D   +L++ L+    Q
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568

Query: 571  LEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR-----DVQ 625
             E+ ++ + E        SE+   Q+   V R   +E+  E  Q+ ++ A R     D++
Sbjct: 1569 FERDLQGRDE-------QSEEKKKQLVRQV-REMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 626  EQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYR 685
            +  A +  + +   E + +L+K            +  Q  +     D T A RE +L   
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRK------------LQAQMKDCMRELDDTRASREEIL--- 1665

Query: 686  EDIINVRTAADHVEEKLK---AEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASIS 742
                     A   E+KLK   AE++ L+E++ A     E  +   Q E +   +EIA+ S
Sbjct: 1666 -------AQAKENEKKLKSMEAEMIQLQEELAA----AERAKRQAQQERDELADEIAN-S 1713

Query: 743  SLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERI 802
            S K  L   +  + +A + QL  EE+ + ++  TEL +++++++          +Q+++I
Sbjct: 1714 SGKGALALEEKRRLEARIAQL--EEELEEEQGNTEL-INDRLKK--------ANLQIDQI 1762

Query: 803  RQADSLERIRAILND 817
                +LER  A  N+
Sbjct: 1763 NTDLNLERSHAQKNE 1777



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 161/795 (20%), Positives = 334/795 (42%), Gaps = 89/795 (11%)

Query: 34   QLEQEFNQKRAKFKELYLAKEEDLKRQNAV--LQAAQDDLGHLRTQLWEAQ-------AE 84
            Q+ ++  +  AK +EL   +E+ L  +N +  ++  Q  L   + QL E         AE
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 85   MENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWA 144
             E ++A  T  +   +E   +++ +  EE    Q +  E  +  ++   L  + E  + A
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958

Query: 145  QYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTE 204
            + +   E+   + + +  E +E+  LE++  K  ++ + L       E  IA     LTE
Sbjct: 959  RQKLQLEKVTTEAKLKKLE-EEQIILEDQNCKLAKEKKLL-------EDRIAEFTTNLTE 1010

Query: 205  AEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH 264
             E+K K L   K K         ++  TDLE  +     Q+  L++   KL  +  ++  
Sbjct: 1011 EEEKSKSLAKLKNK--------HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSD 1062

Query: 265  LLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDD 324
             + + + Q  +LK    K  ++   +   +  +  +  + L  +++R++E    + QED 
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL--KKIRELESQISELQEDL 1120

Query: 325  EQQRLNKRKDHK-KADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL 383
            E +R ++ K  K K D+ EE++       T+ E +   +  ++ L S R      +  +L
Sbjct: 1121 ESERASRNKAEKQKRDLGEELE----ALKTELEDTLDSTAAQQELRSKR----EQEVNIL 1172

Query: 384  LPSGDPFSKSDNDMFKD-GLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPL 442
              + +  +K+     ++   + +Q+ + L        +      KAK      E++ G L
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT---LENERGEL 1229

Query: 443  VGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYV 502
                 V         G  +     +  + QE  +K    E+  T  L   VT+ ++    
Sbjct: 1230 ANEVKVL----LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT-ELADKVTK-LQVELD 1283

Query: 503  SPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQL 562
            + +G    S+++ + L K+               S  E QLQ  Q    E   Q   L  
Sbjct: 1284 NVTGLLSQSDSKSSKLTKDF--------------SALESQLQDTQELLQEENRQKLSLST 1329

Query: 563  MLRQANDQ---LEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQ 619
             L+Q  D+     + +++++E +  +++       Q++ +  + + S   LE  +    +
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE----E 1385

Query: 620  AKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILP-----DTT 674
             KR +Q+ +  L Q  E+      +L+K    LQ         Q+ +D ++       + 
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ---------QELDDLLVDLDHQRQSA 1436

Query: 675  EALRELVLKYREDIINVRT-AADHVEEKLKAEILFLKEQIQA---EQCLKENLEETLQLE 730
              L +   K+ + +   +T +A + EE+ +AE    +++ +A    + L+E +E+  +LE
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496

Query: 731  IEN--CKEEIASISSLKAELERI--KVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQR 786
              N   + E+  + S K ++ +   ++EK +  +EQ + E K + + L+ EL  +E  + 
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556

Query: 787  DFVKLSQTLQVQLER 801
                  Q ++ Q ER
Sbjct: 1557 RLEVNLQAMKAQFER 1571



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 150/693 (21%), Positives = 286/693 (41%), Gaps = 145/693 (20%)

Query: 171  ENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSC 230
            E EM   +E+  K+R      EK++AA +++LTE E    +L A K+ +L   L+AE   
Sbjct: 844  EEEMMAKEEELVKVR------EKQLAA-ENRLTEMETLQSQLMAEKL-QLQEQLQAETEL 895

Query: 231  RTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLES 290
              + E   A L  +K  L+E    L   + E     E+ER QH Q +    + N Q LE 
Sbjct: 896  CAEAEELRARLTAKKQELEEICHDLEARVEE-----EEERCQHLQAEKKKMQQNIQELEE 950

Query: 291  QRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVC 350
            Q   + + +     L  E++    +LKK ++E    +  N +   +K  +E+ I      
Sbjct: 951  Q---LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA----- 1002

Query: 351  ALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDS 410
                 E +  L+ EEE   S     +  +A +             D+ ++ LRR +    
Sbjct: 1003 -----EFTTNLTEEEEKSKSLAKLKNKHEAMI------------TDL-EERLRREEK--- 1041

Query: 411  LGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTK 470
                   Q + L    +     + D SD         ++E    A +  L+M     L K
Sbjct: 1042 -------QRQELEKTRRKLEGDSTDLSD--------QIAEL--QAQIAELKM----QLAK 1080

Query: 471  DQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLG 530
             +E    A+   +EE A                          + N+  K++    +++ 
Sbjct: 1081 KEEELQAALARVEEEAA--------------------------QKNMALKKIRELESQIS 1114

Query: 531  RRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKT-----MKDKQELE-DF 584
               ++  + E +       E + RD  ++L+ +  +  D L+ T     ++ K+E E + 
Sbjct: 1115 ---ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQM--------------AV 630
            +K++ E+           A+  E  ++E++Q  SQA  ++ EQ+                
Sbjct: 1172 LKKTLEEE----------AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221

Query: 631  LMQSREQVSEEL-VRLQKDNDSLQGKHSLHVSLQQAE------DFILPDTTEALRELVLK 683
            L   R +++ E+ V LQ   DS   +  +   LQ+ +      + +  +  + + +L ++
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281

Query: 684  YREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCL--KENLEE-TLQLEIENCKEEIAS 740
              +++  + + +D    KL  +   L+ Q+Q  Q L  +EN ++ +L  +++  ++E  S
Sbjct: 1282 L-DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340

Query: 741  ISSLKAELERIK--VEKGQATVEQLMFEEKNKAQR----LQTELDVSEQVQRDFVKLSQT 794
                  E E  K  +EK  AT+   + + K K +     L+T  +V  ++Q+D   LSQ 
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR 1400

Query: 795  LQVQLERIRQADSLERIRAILN---DTKLTDIN 824
             +   E++   D LE+ +  L    D  L D++
Sbjct: 1401 HE---EKVAAYDKLEKTKTRLQQELDDLLVDLD 1430



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 162/797 (20%), Positives = 320/797 (40%), Gaps = 122/797 (15%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAK---EEDLKRQNAVL 64
            SQ    L +++ + +++ A   +A+Q LE E  +   + K L   K   E   K+  A L
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 65   QAAQ---DDLGHLRTQLWEA----QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASL 117
            Q  Q   ++   +RT+L +     Q E++N+  + + S++   +          ++ ++L
Sbjct: 1255 QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT--------KDFSAL 1306

Query: 118  QAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKA 177
            ++ +++T             QE  Q         R+   L  +L + ++E+N   E  + 
Sbjct: 1307 ESQLQDT-------------QELLQ------EENRQKLSLSTKLKQVEDEKNSFREQLEE 1347

Query: 178  QEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMY 237
            +E+A+        +EK+IA L  ++ + + K+++     V  L    E ++  + DLE  
Sbjct: 1348 EEEAKH------NLEKQIATLHAQVADMKKKMED----SVGCLETAEEVKRKLQKDLE-G 1396

Query: 238  VAVLNTQKSVLQEDAEK----LRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRL 293
            ++  + +K    +  EK    L++EL ++   L+ +RQ    L+   QK  DQ L  ++ 
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK-QKKFDQLLAEEKT 1455

Query: 294  LM------RDMQRMEI-VLTSEQLRQVEELKKKDQEDDEQQRLNKR-----------KDH 335
            +       RD    E     ++ L     L++  ++  E +RLNK+           KD 
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515

Query: 336  KKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL---------LPS 386
                V E  K         EE   QL   E+ L +T  +   L+  L          L  
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575

Query: 387  GDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGAD 446
             D  S+         +R  ++   L      +S A+     A+    +D  D    +  D
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEA--ELEDERKQRSMAVA----ARKKLEMDLKDLEAHI--D 1627

Query: 447  SVSENFDTA--SLGSLQ-MPSGFMLTKDQERA----IKAMTPEQEETASLLSSVTQGMES 499
            S ++N D A   L  LQ      M   D  RA    I A   E E+    + +    ++ 
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687

Query: 500  AYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKK 559
               +    +  ++ E + L  E+ N+  K     +     E ++  ++ +  E +   + 
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747

Query: 560  LQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQ 619
            +   L++AN Q+++   D   LE    Q +E++  Q+       + ++ L  +LQ+    
Sbjct: 1748 INDRLKKANLQIDQINTD-LNLERSHAQKNENARQQLE------RQNKELKVKLQEMEGT 1800

Query: 620  AKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRE 679
             K   +  +  L     Q+ E+L     DN++ +         +QA    +  T + L++
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQL-----DNETKE---------RQAACKQVRRTEKKLKD 1846

Query: 680  LVLKYREDIINVRTAADHVE------EKLKAEILFLKEQIQAEQCLKENLEETLQLEIEN 733
            ++L+  ++  N     D  +      ++LK ++   +E+ Q     +  L+  L+   E 
Sbjct: 1847 VLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATET 1906

Query: 734  CKEEIASISSLKAELER 750
                   +SSLK +L R
Sbjct: 1907 ADAMNREVSSLKNKLRR 1923



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 25/209 (11%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQ---EFNQKRAKFKELYLAKEEDLKRQNAVL 64
            +Q +  L++     E IN    +A  Q++Q   + N +R+  ++   A+++ L+RQN   
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ-LERQNK-- 1788

Query: 65   QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKET 124
                     L+ +L E +     +K+    S    +  I +++ Q   E    QA  K+ 
Sbjct: 1789 --------ELKVKLQEMEG---TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQ- 1836

Query: 125  VRDYEHQFH---LRLEQERTQWAQYRESAER---EIADLRRRLSEGQEEENLEN-EMKKA 177
            VR  E +     L+++ ER    QY++ A++    +  L+R+L E +EE    N   +K 
Sbjct: 1837 VRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896

Query: 178  QEDAEKLRSVVMPMEKEIAALKDKLTEAE 206
            Q + E        M +E+++LK+KL   +
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLRRGD 1925



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 43/157 (27%), Positives = 76/157 (48%), Gaps = 15/157 (9%)

Query: 655 KHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQ 714
           K  L VS Q+ E     +    +RE  L     +  + T    ++ +L AE L L+EQ+Q
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET----LQSQLMAEKLQLQEQLQ 890

Query: 715 AEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRL 774
           AE  L    EE L+  +   K+E+  I     +LE  +VE+ +   + L  E+K   Q +
Sbjct: 891 AETELCAEAEE-LRARLTAKKQELEEICH---DLE-ARVEEEEERCQHLQAEKKKMQQNI 945

Query: 775 QTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERI 811
           Q   ++ EQ++ +    S   ++QLE++     L+++
Sbjct: 946 Q---ELEEQLEEE---ESARQKLQLEKVTTEAKLKKL 976


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 179/859 (20%), Positives = 349/859 (40%), Gaps = 149/859 (17%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AEL K+  ++ R    L  E  +K  K ++      E+++++NA   A Q     L+ QL
Sbjct: 446  AELNKLRQDYAR----LVNELTEKTGKLQQ------EEVQKKNAEQAATQ-----LKVQL 490

Query: 79   WEAQAEMENIKAIA---TVSENTKQEAIDEVKRQWREEVASLQAVMKETV--RDYEHQFH 133
             EA+   E +++     T      Q+ +         EV SL + + +T+  +    Q  
Sbjct: 491  QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA----EKLRSVVM 189
            ++L +   +     ES + ++ D+  +    + +    +    AQ  A    E+L  V+ 
Sbjct: 551  MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610

Query: 190  PMEKEIAALKDKLTEAEDKI--KELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
              +K+I   +D L    D++  KE E   ++ +N  L+AE      ++   A+ N Q + 
Sbjct: 611  EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE------VQKLQALANEQAAA 664

Query: 248  LQEDAEKLRKELH---EVCHLLEQERQQHNQLK-HTWQKANDQFLESQRLLMRDMQRMEI 303
              E  EK+++ ++   +   LLE++ Q     K   ++  NDQ     + L  ++Q+++ 
Sbjct: 665  AHE-LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ----NKALKSEVQKLQ- 718

Query: 304  VLTSEQLRQ--VEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQL 361
             L SEQ  +  VE+++K  QE          KD K   VEE ++  ++          Q+
Sbjct: 719  TLVSEQPNKDVVEQMEKCIQE----------KDEKLKTVEELLETGLI----------QV 758

Query: 362  SNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSG---SLQ 418
            + +EE L++ R    SL            +K   D+      +A+  D +  +     L+
Sbjct: 759  ATKEEELNAIRTENSSL------------TKEVQDL------KAKQNDQVSFASLVEELK 800

Query: 419  SKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKA 478
                  + K KS   L E++   +   +   +   T+ +  LQ      L K +E  +  
Sbjct: 801  KVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQN-----LLKGKEEQMNT 855

Query: 479  MTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSN 538
            M    EE    L++  + ++             + E   L+  V        +     S 
Sbjct: 856  MKAVLEEKEKDLANTGKWLQDL-----------QEENESLKAHVQEVAQHNLKEASSASQ 904

Query: 539  YEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED-------FIKQSSED 591
            +E+    ++I   E  +++K+L+ ML++    L    +  Q+++D        I+Q  + 
Sbjct: 905  FEE----LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ 960

Query: 592  SSHQISALVLRAQASEILLEE------LQQGLSQAKRDVQEQMAVLMQSREQVSEELVRL 645
            +  Q S+     +  +++ E       L   L   K  V+ Q       RE+  E +  L
Sbjct: 961  NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEAL 1020

Query: 646  QKDNDSLQGK-HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE----- 699
                  LQ K +      QQ  + +  +  E L++L  K     ++V +   + E     
Sbjct: 1021 ASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK-----VSVPSNLSYGEWLHGF 1075

Query: 700  EKLKAEILFLKEQIQAEQCLKENLEET------LQLEIENCKEEIASISSLKAELER--- 750
            EK   E +      +  + L+  L+E       LQLE E  K  +A    +  +L+R   
Sbjct: 1076 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1135

Query: 751  -------IKVEKGQATVEQL---MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ-VQL 799
                   +KV++   T++Q+       + + +RL++E    E ++R+   L   L+  ++
Sbjct: 1136 QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEM 1195

Query: 800  ERIRQADSLERIRAILNDT 818
            ER      +  ++A LN+T
Sbjct: 1196 ERSTYVTEVRELKAQLNET 1214



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 71/368 (19%), Positives = 161/368 (43%), Gaps = 44/368 (11%)

Query: 468 LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
           L K  +  +  +  + +E   LL++V +       + +  R    T+  + +KE  N   
Sbjct: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKED-----AAATKDRCKQLTQEMMTEKERSNV-- 371

Query: 528 KLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQ 587
            + R  D     EK+    Q +   +  + +++Q+  +Q  +Q+E  +   ++    ++ 
Sbjct: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431

Query: 588 SSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQK 647
           +  ++++Q+ +     Q++E  L +L+Q  ++   ++ E+   L Q           +QK
Sbjct: 432 AVSNTTNQLES----KQSAE--LNKLRQDYARLVNELTEKTGKLQQE---------EVQK 476

Query: 648 DNDSLQGKHSLHVSLQQAE-------DFILPDTTE---ALRELVLKYREDIINVRTAADH 697
            N + Q    L V LQ+AE        +I   T E   A ++L  K+      V++    
Sbjct: 477 KN-AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535

Query: 698 VEEKL--KAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEK 755
           + + L  K ++     Q+   +  + N EE+LQ+++++  E+     +LKA++++   + 
Sbjct: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ---NEALKAQIQQFHSQI 592

Query: 756 GQATVEQLMFEEKNKA------QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 809
              T   ++ EE +K       Q  QTE  ++ +  R   K  +   +Q         ++
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652

Query: 810 RIRAILND 817
           +++A+ N+
Sbjct: 653 KLQALANE 660


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 174/800 (21%), Positives = 339/800 (42%), Gaps = 107/800 (13%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL--YLAKEEDLKRQNAVLQAAQDDL 71
            L +RV E E+IN+E     ++LE E  + + +  +L   L K E  KR        +  +
Sbjct: 934  LSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKR------TTEHKV 987

Query: 72   GHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQ 131
             +L  ++     ++  +   A V +   Q+ +D++  +  E+++SL     +  +  + +
Sbjct: 988  KNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHME-EEKLSSLSKANLKLEQQVD-E 1045

Query: 132  FHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE-ENLENEMKKAQEDAEKLRSVVMP 190
                LEQER    + R + ERE+  L   L   +E  ENLE+  +   E+  K    +  
Sbjct: 1046 LEGALEQER----KARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQ 1101

Query: 191  MEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQE 250
            M  ++   K  + + +  +KEL+ +++K+L   LEAE++ R  +E        +++ L +
Sbjct: 1102 MNSKVENEKGLVAQLQKTVKELQ-TQIKDLKEKLEAERTTRAKME-------RERADLTQ 1153

Query: 251  DAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQL 310
            D   L + L EV            QL+ T +K   +F +  R +       E    S + 
Sbjct: 1154 DLADLNERLEEV------GGSSLAQLEIT-KKQETKFQKLHRDMEEATLHFETTSASLKK 1206

Query: 311  RQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQ-EESSAQLSNEEEHLD 369
            R  + L + + + +  Q++ ++ +  K+D++ E+       LT+ E+ +   +N E+   
Sbjct: 1207 RHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVD----DLLTRVEQMTRAKANAEKLCT 1262

Query: 370  STRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAK 429
                 +H   A L     D  ++  ND+       AQ T     SG    +         
Sbjct: 1263 LYEERLHEATAKL-----DKVTQLANDL------AAQKTKLWSESGEFLRR--------- 1302

Query: 430  SAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASL 489
                L+E +   L+   S  ++  T  +  L+       TK Q     A+   Q +   L
Sbjct: 1303 ----LEEKE--ALINQLSREKSNFTRQIEDLRGQLE-KETKSQSALAHALQKAQRDCDLL 1355

Query: 490  LSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQ 549
                 +  E   V    +R +S+    ++Q  +    N + R  D+  + +K+L  I++Q
Sbjct: 1356 REQYEEEQE---VKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDL-EDAKKEL-AIRLQ 1410

Query: 550  E-AETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEI 608
            E AE           L +A  QL+  + D   L D  K              +R+ A+ +
Sbjct: 1411 EAAEAMGVANARNASLERARHQLQLELGD--ALSDLGK--------------VRSAAARL 1454

Query: 609  LLEELQQG--LSQAKRDVQEQMAVLMQSREQV---SEELVRLQKD-NDSLQGKHSLHVSL 662
              ++LQ G  L+  K+  +E  A+L  S+++V   S EL++L+    +S+ G+ +L    
Sbjct: 1455 DQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETL---- 1510

Query: 663  QQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKEN 722
             + E+  L +    L   V +  +++  +      +EE+ K E+    E  + E  L+ N
Sbjct: 1511 -RRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEE-KTEVQVTLE--ETEGALERN 1566

Query: 723  LEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNKAQRLQTELDVSE 782
              + L  ++E        +   KAELER K+ +    +E    +++     LQ+ LD   
Sbjct: 1567 ESKILHFQLE--------LLEAKAELER-KLSEKDEEIENFRRKQQCTIDSLQSSLDSEA 1617

Query: 783  QVQRDFVKLSQTLQVQLERI 802
            + + +  +L + ++  L  +
Sbjct: 1618 KSRIEVTRLKKKMEEDLNEM 1637



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 176/887 (19%), Positives = 343/887 (38%), Gaps = 157/887 (17%)

Query: 8    SQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAA 67
            S+ ++ L+Q+V ELE    +  +A+   E+E ++            E +LK     ++  
Sbjct: 1033 SKANLKLEQQVDELEGALEQERKARMNCERELHKL-----------EGNLKLNRESMENL 1081

Query: 68   QDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRD 127
            +    HL  +L + + E+  +        N+K E    +  Q ++ V  LQ  +K+    
Sbjct: 1082 ESSQRHLAEELRKKELELSQM--------NSKVENEKGLVAQLQKTVKELQTQIKDLKEK 1133

Query: 128  YEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA-----E 182
             E +   R + ER      R    +++ADL  RL E       + E+ K QE        
Sbjct: 1134 LEAERTTRAKMERE-----RADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHR 1188

Query: 183  KLRSVVMPMEKEIAALK----DKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
             +    +  E   A+LK    D L E E +++ L+  K K     LE +KS   DL++ V
Sbjct: 1189 DMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQK-----LEKDKS---DLQLEV 1240

Query: 239  AVLNT---QKSVLQEDAEKL----RKELHEVCHLLEQERQQHNQLK----HTWQKAND-- 285
              L T   Q +  + +AEKL     + LHE    L++  Q  N L       W ++ +  
Sbjct: 1241 DDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFL 1300

Query: 286  QFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQ--------RLNKRKDHKK 337
            + LE +  L+  + R +   T    RQ+E+L+ + +++ + Q        +  +  D  +
Sbjct: 1301 RRLEEKEALINQLSREKSNFT----RQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLR 1356

Query: 338  ADVEEEIKIPVVCALTQEESSAQL--------SNEEEHLDSTRGSVHSLDAGLL-LPSGD 388
               EEE ++      T  + +A++        +N  +  +    +   L   L       
Sbjct: 1357 EQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAM 1416

Query: 389  PFSKSDNDMFKDGLRRAQST--DSLGTSGSLQSKALGYNYK----AKSAGNLDESDFGPL 442
              + + N   +    + Q    D+L   G ++S A   + K     K+  +  +      
Sbjct: 1417 GVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQ 1476

Query: 443  VGADSVSENFDTASLGSLQMPSGFMLT-KDQERAIKAMTPEQEETASLLSSVTQGMESAY 501
               D+  +     S   L++ + +  +   QE   +     QEE ++L + V +G ++  
Sbjct: 1477 ALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLT 1536

Query: 502  VSPSGYRLVSE--TEWNLLQKEVHNA----------------------GNKLGRRCDMCS 537
                  +L+ E  TE  +  +E   A                        KL  + +   
Sbjct: 1537 EMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIE 1596

Query: 538  NYEKQ-------LQGIQIQEAETRDQVKKL-----------QLMLRQAN----------D 569
            N+ ++       LQ     EA++R +V +L           +L L  AN           
Sbjct: 1597 NFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLG 1656

Query: 570  QLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMA 629
            QL+  +KD Q   D   Q + D   Q++    R    +  LE+L+    Q +R  +    
Sbjct: 1657 QLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEE 1716

Query: 630  VLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDII 689
             L+++ E+++   +   ++   L  K  L   + + +                K  E+++
Sbjct: 1717 ELLEATERIN---LFYTQNTSLLSQKKKLEADVARMQ----------------KEAEEVV 1757

Query: 690  NVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELE 749
                 A+   +K   E   L E+++ +Q    +LE T     EN ++ I  +    AE E
Sbjct: 1758 QECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTR----ENMEQTITDLQKRLAEAE 1813

Query: 750  RIKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 796
            ++ +   +  +++L    +     L+ E+  S + QR   +L + ++
Sbjct: 1814 QMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIK 1860



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 158/802 (19%), Positives = 316/802 (39%), Gaps = 130/802 (16%)

Query: 43   RAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEA 102
            R  FK   L K  ++  + A L+   ++   L+  L +++ + E +KA        KQ +
Sbjct: 843  RLFFKIKPLVKSSEVGEEVAGLK---EECAQLQKALEKSEFQREELKA--------KQVS 891

Query: 103  IDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLS 162
            + + K    + +  LQA  +ET+ + E Q    ++ +    A+ +E +ER   +      
Sbjct: 892  LTQEKN---DLILQLQAE-QETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSE 947

Query: 163  EGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNH 222
                   LE+E  + +++ + L ++++  EKE    + K+    ++++ L    + +LN 
Sbjct: 948  LTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNED-ISKLNR 1006

Query: 223  YL----EAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKH 278
                  EA +    DL M    L++    L +   KL +++ E+   LEQER+     + 
Sbjct: 1007 AAKVVQEAHQQTLDDLHMEEEKLSS----LSKANLKLEQQVDELEGALEQERKARMNCER 1062

Query: 279  TWQKANDQFLESQRLLMRD-MQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKK 337
               K     LE    L R+ M+ +E    S Q    EEL+KK+ E     ++N + +++K
Sbjct: 1063 ELHK-----LEGNLKLNRESMENLE----SSQRHLAEELRKKELE---LSQMNSKVENEK 1110

Query: 338  ADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDM 397
              V +  K       T +E   Q+ + +E L++ R +   ++                  
Sbjct: 1111 GLVAQLQK-------TVKELQTQIKDLKEKLEAERTTRAKMER----------------- 1146

Query: 398  FKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV-GADSVSENFDTAS 456
                  RA  T  L        +  G +          E+ F  L    +  + +F+T S
Sbjct: 1147 -----ERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTS 1201

Query: 457  LGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWN 516
                       L K    ++  +  + E     L  V Q +E               + +
Sbjct: 1202 AS---------LKKRHADSLAELEGQVEN----LQQVKQKLEK--------------DKS 1234

Query: 517  LLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMK 576
             LQ EV +   ++ +     +N EK      + E    +   KL  + + AND   +  K
Sbjct: 1235 DLQLEVDDLLTRVEQMTRAKANAEKLCT---LYEERLHEATAKLDKVTQLANDLAAQKTK 1291

Query: 577  DKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQE---QMAVLMQ 633
               E  +F++               R +  E L+ +L +  S   R +++   Q+    +
Sbjct: 1292 LWSESGEFLR---------------RLEEKEALINQLSREKSNFTRQIEDLRGQLEKETK 1336

Query: 634  SREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRT 693
            S+  ++  L + Q+D D L+ ++     ++      L      + +  +KY  ++I    
Sbjct: 1337 SQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTE 1396

Query: 694  AADHVEEKLKAEILFLKEQIQAEQCLKENLEET---LQLEIENCKEEIASISSLKAELER 750
              +  +++L   +    E +        +LE     LQLE+ +   ++  + S  A L++
Sbjct: 1397 DLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQ 1456

Query: 751  IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQ----VQRDFVKLSQTLQVQLERIRQAD 806
             +++ G+A     + + K K +  Q  LD S++    +  + +KL  T +   E I   +
Sbjct: 1457 KQLQSGKA-----LADWKQKHEESQALLDASQKEVQALSTELLKLKNTYE---ESIVGQE 1508

Query: 807  SLERIRAILNDTKLTDINQLPE 828
            +L R    L +      NQ+ E
Sbjct: 1509 TLRRENKNLQEEISNLTNQVRE 1530



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 70/350 (20%), Positives = 142/350 (40%), Gaps = 59/350 (16%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            SLQ  +    K   E  R ++++E++ N+            E  L   N  +  A   LG
Sbjct: 1608 SLQSSLDSEAKSRIEVTRLKKKMEEDLNEM-----------ELQLSCANRQVSEATKSLG 1656

Query: 73   HLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQW-REEVASLQAVMKETVRDYEHQ 131
             L+ Q+ + Q ++++   +   S+  +Q A+ E +    + E+  L+++ ++T R     
Sbjct: 1657 QLQIQIKDLQMQLDDSTQLN--SDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLS 1714

Query: 132  FHLRLEQ---------ERTQWAQYRESAEREIADLRRRLSEGQEE--------------- 167
                LE          + T     ++  E ++A +++   E  +E               
Sbjct: 1715 EEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEA 1774

Query: 168  ENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEA---------------EDKIKEL 212
             NL  E+KK Q+    L      ME+ I  L+ +L EA               E +++EL
Sbjct: 1775 ANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVREL 1834

Query: 213  EASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQ 272
            E     E+    EA++  R  LE  +  L  Q    +++  +++ ++ ++   ++  +QQ
Sbjct: 1835 EGELEGEIRRSAEAQRGARR-LERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQ 1893

Query: 273  HNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQE 322
                +    +   ++ + Q  L    +R E+  +     QV +LK K +E
Sbjct: 1894 VEVAETQANQYLSKYKKQQHELNEVKERAEVAES-----QVNKLKIKARE 1938


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 180/862 (20%), Positives = 358/862 (41%), Gaps = 134/862 (15%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AEL K+  ++ R    L  E  +K  K ++      E+++++NA   A Q     L+ QL
Sbjct: 446  AELNKLRQDYAR----LVNELTEKTGKLQQ------EEVQKKNAEQAATQ-----LKVQL 490

Query: 79   WEAQAEMENIKAIA---TVSENTKQEAIDEVKRQWREEVASLQAVMKETV--RDYEHQFH 133
             EA+   E +++     T      Q+ +         EV SL + + +T+  +    Q  
Sbjct: 491  QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA----EKLRSVVM 189
            ++L +   +     ES + ++ D+  +    + +    +    AQ  A    E+L  V+ 
Sbjct: 551  MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610

Query: 190  PMEKEIAALKDKLTEAEDKI--KELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
              +K+I   +D L    D++  KE E   ++ +N  L+AE      ++   A+ N Q + 
Sbjct: 611  EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE------VQKLQALANEQAAA 664

Query: 248  LQEDAEKLRKELH---EVCHLLEQERQQHNQLK-HTWQKANDQFLESQRLLMRDMQRMEI 303
              E  EK+++ ++   +   LLE++ Q     K   ++  NDQ     + L  ++Q+++ 
Sbjct: 665  AHE-LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ----NKALKSEVQKLQ- 718

Query: 304  VLTSEQLRQ--VEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEES---- 357
             L SEQ  +  VE+++K  QE          KD K   VEE ++  ++   T+EE     
Sbjct: 719  TLVSEQPNKDVVEQMEKCIQE----------KDEKLKTVEELLETGLIQVATKEEELNAI 768

Query: 358  ---SAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTS 414
               ++ L+ E + L + +    S  A L+    +   K  ++  KDG  + +S + L   
Sbjct: 769  RTENSSLTKEVQDLKAKQNDQVSF-ASLV----EELKKVIHE--KDG--KIKSVEEL--- 816

Query: 415  GSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQER 474
              L+++ L    K K+  +L +          ++ E      L   Q  S  + +K QE 
Sbjct: 817  --LEAELLKVANKEKTVQDLKQE-------IKALKEEIGNVQLEKAQQLS--ITSKVQE- 864

Query: 475  AIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCD 534
             ++ +   +EE  + + +V +  E    +   +    + E   L+  V        +   
Sbjct: 865  -LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923

Query: 535  MCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED-------FIKQ 587
              S +E+    ++I   E  +++K+L+ ML++    L    +  Q+++D        I+Q
Sbjct: 924  SASQFEE----LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979

Query: 588  SSEDSSHQISALVLRAQASEILLEE------LQQGLSQAKRDVQEQMAVLMQSREQVSEE 641
              + +  Q S+     +  +++ E       L   L   K  V+ Q       RE+  E 
Sbjct: 980  LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1039

Query: 642  LVRLQKDNDSLQGK-HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE- 699
            +  L      LQ K +      QQ  + +  +  E L++L  K     ++V +   + E 
Sbjct: 1040 MEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK-----VSVPSNLSYGEW 1094

Query: 700  ----EKLKAEILFLKEQIQAEQCLKENLEET------LQLEIENCKEEIASISSLKAELE 749
                EK   E +      +  + L+  L+E       LQLE E  K  +A    +  +L+
Sbjct: 1095 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1154

Query: 750  R----------IKVEKGQATVEQL---MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 796
            R          +KV++   T++Q+       + + +RL++E    E ++R+   L   L+
Sbjct: 1155 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1214

Query: 797  -VQLERIRQADSLERIRAILND 817
              ++ER      +  ++ +L +
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTE 1236



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 111/513 (21%), Positives = 212/513 (41%), Gaps = 104/513 (20%)

Query: 14   LQQRVAEL-EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            L+Q +  L E+I    L   QQL      K  + + L   KEE +    AVL+  + DL 
Sbjct: 834  LKQEIKALKEEIGNVQLEKAQQLS--ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891

Query: 73   HLRTQLWEAQAEMENIKA-IATVSENTKQEA--------IDEVKRQWREEVASLQAVMKE 123
            +    L + Q E E++KA +  V+++  +EA        ++ V ++   E+  L+A++KE
Sbjct: 892  NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951

Query: 124  -------------TVRDYEHQFHLRLEQERTQWAQYRES-------------AEREIADL 157
                          V+D    F  ++EQ + Q  Q   S              E+EI+ L
Sbjct: 952  RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011

Query: 158  RRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLT----EAEDKIK--E 211
               L     ++ +E++ KK  +  EK    +  +      L+DK+     E + +++  E
Sbjct: 1012 WNELD--SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1069

Query: 212  LEASKVKE-----------------LNHYLEAEKSCRTD---------LEMYVAVLNTQK 245
            LEA +V +                 L+ + +  K C            LE  +   +   
Sbjct: 1070 LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMH 1129

Query: 246  SVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL 305
            ++LQ + EK +  L E   +L++ ++   Q ++ W+   D   ES + +    ++M+   
Sbjct: 1130 TLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD---ESHKTI----KQMQSSF 1182

Query: 306  TSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEE 365
            TS +    +EL++   E+ + + L + ++H + ++E+           + E S  ++   
Sbjct: 1183 TSSE----QELERLRSENKDIENLRREREHLEMELEK----------AEMERSTYVTEVR 1228

Query: 366  EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDS---LGTSGSLQSKAL 422
            E  D        LD        D +S++     +  L +AQ  ++   L T  + + K  
Sbjct: 1229 ELKDLLTELQKKLD--------DSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVA 1280

Query: 423  GYNYKAKSAGNLDESDFGPLVGADSVSENFDTA 455
            G  +KA+ +  L +S      G  +V EN D +
Sbjct: 1281 GDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1313



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 135/743 (18%), Positives = 292/743 (39%), Gaps = 106/743 (14%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE--EDLKRQNAVLQAAQDD 70
            SLQ +V ++ + N E L+AQ  ++Q  +Q  A+     LA+E  + +  ++  ++  +D 
Sbjct: 566  SLQMQVQDILEQN-EALKAQ--IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDS 622

Query: 71   LGHLRTQLWEAQAEMENIKAIATV--SENTKQEAIDEVKRQWREEVASLQA---VMKETV 125
            L   R +L   + E+++I+ +  +  +E  K +A+   +     E+  +Q    V  + +
Sbjct: 623  LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682

Query: 126  RDYEHQFHLRLEQERTQWA---QYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAE 182
            R  E Q    +  +  ++       ++ + E+  L+  +SE   ++ +E   K  QE  E
Sbjct: 683  RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742

Query: 183  KLRSV----------VMPMEKEIAALKDKLTEAEDKIKELEAS----------------- 215
            KL++V          V   E+E+ A++ + +    ++++L+A                  
Sbjct: 743  KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802

Query: 216  ------KVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                  K+K +   LEAE     + E  V  L  +   L+E+   ++ E  +   +  + 
Sbjct: 803  IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKV 862

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
            ++  N L     K  ++ + + + ++ + ++ ++  T + L+ ++E  +  +   ++   
Sbjct: 863  QELQNLL-----KGKEEQMNTMKAVLEEKEK-DLANTGKWLQDLQEENESLKAHVQEVAQ 916

Query: 330  NKRKDHKKADVEEEIKIPVVCALTQEES-----SAQLSNEEEHLDSTRGSVHSL-DAGLL 383
            +  K+   A   EE++I     L ++E+      A L   E  L S    +  + D   L
Sbjct: 917  HNLKEASSASQFEELEI----VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL 972

Query: 384  LPSGDPFSKSDN-----------DMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAG 432
              S     K  N           ++ K    R +     G    L S      ++ K   
Sbjct: 973  FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS--GLWNELDSLKDAVEHQRKKNN 1030

Query: 433  NLDESDFGPLVGADSVSENFD-----TASLGSLQMPSGFMLTKDQERAI--KAMTPEQEE 485
            +L E ++  +    S  +        T+     Q+ +  +  K+  + +  K   P    
Sbjct: 1031 DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L    +  +      SG   V   E  L  KE       L   C+   +   + +G
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL--KEADEMHTLLQLECEKYKSVLAETEG 1148

Query: 546  I---------------QIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELE------DF 584
            I               +++  E+   +K++Q     +  +LE+   + +++E      + 
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREH 1208

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR 644
            ++   E +  + S  V   +  + LL ELQ+ L  +  +   Q   L   + Q++E L +
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268

Query: 645  LQ-KDNDSLQGKHSLHVSLQQAE 666
            L+ + N+  +    LH + Q  E
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLE 1291



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 71/368 (19%), Positives = 161/368 (43%), Gaps = 44/368 (11%)

Query: 468 LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
           L K  +  +  +  + +E   LL++V +       + +  R    T+  + +KE  N   
Sbjct: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKED-----AAATKDRCKQLTQEMMTEKERSNV-- 371

Query: 528 KLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQ 587
            + R  D     EK+    Q +   +  + +++Q+  +Q  +Q+E  +   ++    ++ 
Sbjct: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431

Query: 588 SSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQK 647
           +  ++++Q+ +     Q++E  L +L+Q  ++   ++ E+   L Q           +QK
Sbjct: 432 AVSNTTNQLES----KQSAE--LNKLRQDYARLVNELTEKTGKLQQE---------EVQK 476

Query: 648 DNDSLQGKHSLHVSLQQAE-------DFILPDTTE---ALRELVLKYREDIINVRTAADH 697
            N + Q    L V LQ+AE        +I   T E   A ++L  K+      V++    
Sbjct: 477 KN-AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535

Query: 698 VEEKL--KAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEK 755
           + + L  K ++     Q+   +  + N EE+LQ+++++  E+     +LKA++++   + 
Sbjct: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ---NEALKAQIQQFHSQI 592

Query: 756 GQATVEQLMFEEKNKA------QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 809
              T   ++ EE +K       Q  QTE  ++ +  R   K  +   +Q         ++
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652

Query: 810 RIRAILND 817
           +++A+ N+
Sbjct: 653 KLQALANE 660


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 180/862 (20%), Positives = 358/862 (41%), Gaps = 134/862 (15%)

Query: 19   AELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            AEL K+  ++ R    L  E  +K  K ++      E+++++NA   A Q     L+ QL
Sbjct: 446  AELNKLRQDYAR----LVNELTEKTGKLQQ------EEVQKKNAEQAATQ-----LKVQL 490

Query: 79   WEAQAEMENIKAIA---TVSENTKQEAIDEVKRQWREEVASLQAVMKETV--RDYEHQFH 133
             EA+   E +++     T      Q+ +         EV SL + + +T+  +    Q  
Sbjct: 491  QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDA----EKLRSVVM 189
            ++L +   +     ES + ++ D+  +    + +    +    AQ  A    E+L  V+ 
Sbjct: 551  MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610

Query: 190  PMEKEIAALKDKLTEAEDKI--KELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSV 247
              +K+I   +D L    D++  KE E   ++ +N  L+AE      ++   A+ N Q + 
Sbjct: 611  EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE------VQKLQALANEQAAA 664

Query: 248  LQEDAEKLRKELH---EVCHLLEQERQQHNQLK-HTWQKANDQFLESQRLLMRDMQRMEI 303
              E  EK+++ ++   +   LLE++ Q     K   ++  NDQ     + L  ++Q+++ 
Sbjct: 665  AHE-LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ----NKALKSEVQKLQ- 718

Query: 304  VLTSEQLRQ--VEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEES---- 357
             L SEQ  +  VE+++K  QE          KD K   VEE ++  ++   T+EE     
Sbjct: 719  TLVSEQPNKDVVEQMEKCIQE----------KDEKLKTVEELLETGLIQVATKEEELNAI 768

Query: 358  ---SAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTS 414
               ++ L+ E + L + +    S  A L+    +   K  ++  KDG  + +S + L   
Sbjct: 769  RTENSSLTKEVQDLKAKQNDQVSF-ASLV----EELKKVIHE--KDG--KIKSVEEL--- 816

Query: 415  GSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQER 474
              L+++ L    K K+  +L +          ++ E      L   Q  S  + +K QE 
Sbjct: 817  --LEAELLKVANKEKTVQDLKQE-------IKALKEEIGNVQLEKAQQLS--ITSKVQE- 864

Query: 475  AIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCD 534
             ++ +   +EE  + + +V +  E    +   +    + E   L+  V        +   
Sbjct: 865  -LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923

Query: 535  MCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELED-------FIKQ 587
              S +E+    ++I   E  +++K+L+ ML++    L    +  Q+++D        I+Q
Sbjct: 924  SASQFEE----LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979

Query: 588  SSEDSSHQISALVLRAQASEILLEE------LQQGLSQAKRDVQEQMAVLMQSREQVSEE 641
              + +  Q S+     +  +++ E       L   L   K  V+ Q       RE+  E 
Sbjct: 980  LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1039

Query: 642  LVRLQKDNDSLQGK-HSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVE- 699
            +  L      LQ K +      QQ  + +  +  E L++L  K     ++V +   + E 
Sbjct: 1040 MEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK-----VSVPSNLSYGEW 1094

Query: 700  ----EKLKAEILFLKEQIQAEQCLKENLEET------LQLEIENCKEEIASISSLKAELE 749
                EK   E +      +  + L+  L+E       LQLE E  K  +A    +  +L+
Sbjct: 1095 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1154

Query: 750  R----------IKVEKGQATVEQL---MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQ 796
            R          +KV++   T++Q+       + + +RL++E    E ++R+   L   L+
Sbjct: 1155 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1214

Query: 797  -VQLERIRQADSLERIRAILND 817
              ++ER      +  ++ +L +
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTE 1236



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 111/513 (21%), Positives = 212/513 (41%), Gaps = 104/513 (20%)

Query: 14   LQQRVAEL-EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLG 72
            L+Q +  L E+I    L   QQL      K  + + L   KEE +    AVL+  + DL 
Sbjct: 834  LKQEIKALKEEIGNVQLEKAQQLS--ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA 891

Query: 73   HLRTQLWEAQAEMENIKA-IATVSENTKQEA--------IDEVKRQWREEVASLQAVMKE 123
            +    L + Q E E++KA +  V+++  +EA        ++ V ++   E+  L+A++KE
Sbjct: 892  NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951

Query: 124  -------------TVRDYEHQFHLRLEQERTQWAQYRES-------------AEREIADL 157
                          V+D    F  ++EQ + Q  Q   S              E+EI+ L
Sbjct: 952  RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011

Query: 158  RRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLT----EAEDKIK--E 211
               L     ++ +E++ KK  +  EK    +  +      L+DK+     E + +++  E
Sbjct: 1012 WNELD--SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE 1069

Query: 212  LEASKVKE-----------------LNHYLEAEKSCRTD---------LEMYVAVLNTQK 245
            LEA +V +                 L+ + +  K C            LE  +   +   
Sbjct: 1070 LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMH 1129

Query: 246  SVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVL 305
            ++LQ + EK +  L E   +L++ ++   Q ++ W+   D   ES + +    ++M+   
Sbjct: 1130 TLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD---ESHKTI----KQMQSSF 1182

Query: 306  TSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEE 365
            TS +    +EL++   E+ + + L + ++H + ++E+           + E S  ++   
Sbjct: 1183 TSSE----QELERLRSENKDIENLRREREHLEMELEK----------AEMERSTYVTEVR 1228

Query: 366  EHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDS---LGTSGSLQSKAL 422
            E  D        LD        D +S++     +  L +AQ  ++   L T  + + K  
Sbjct: 1229 ELKDLLTELQKKLD--------DSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVA 1280

Query: 423  GYNYKAKSAGNLDESDFGPLVGADSVSENFDTA 455
            G  +KA+ +  L +S      G  +V EN D +
Sbjct: 1281 GDLHKAQQSLELIQSKIVKAAGDTTVIENSDVS 1313



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 135/743 (18%), Positives = 292/743 (39%), Gaps = 106/743 (14%)

Query: 13   SLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKE--EDLKRQNAVLQAAQDD 70
            SLQ +V ++ + N E L+AQ  ++Q  +Q  A+     LA+E  + +  ++  ++  +D 
Sbjct: 566  SLQMQVQDILEQN-EALKAQ--IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDS 622

Query: 71   LGHLRTQLWEAQAEMENIKAIATV--SENTKQEAIDEVKRQWREEVASLQA---VMKETV 125
            L   R +L   + E+++I+ +  +  +E  K +A+   +     E+  +Q    V  + +
Sbjct: 623  LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682

Query: 126  RDYEHQFHLRLEQERTQWA---QYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAE 182
            R  E Q    +  +  ++       ++ + E+  L+  +SE   ++ +E   K  QE  E
Sbjct: 683  RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742

Query: 183  KLRSV----------VMPMEKEIAALKDKLTEAEDKIKELEAS----------------- 215
            KL++V          V   E+E+ A++ + +    ++++L+A                  
Sbjct: 743  KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802

Query: 216  ------KVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQE 269
                  K+K +   LEAE     + E  V  L  +   L+E+   ++ E  +   +  + 
Sbjct: 803  IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKV 862

Query: 270  RQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRL 329
            ++  N L     K  ++ + + + ++ + ++ ++  T + L+ ++E  +  +   ++   
Sbjct: 863  QELQNLL-----KGKEEQMNTMKAVLEEKEK-DLANTGKWLQDLQEENESLKAHVQEVAQ 916

Query: 330  NKRKDHKKADVEEEIKIPVVCALTQEES-----SAQLSNEEEHLDSTRGSVHSL-DAGLL 383
            +  K+   A   EE++I     L ++E+      A L   E  L S    +  + D   L
Sbjct: 917  HNLKEASSASQFEELEI----VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL 972

Query: 384  LPSGDPFSKSDN-----------DMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAG 432
              S     K  N           ++ K    R +     G    L S      ++ K   
Sbjct: 973  FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS--GLWNELDSLKDAVEHQRKKNN 1030

Query: 433  NLDESDFGPLVGADSVSENFD-----TASLGSLQMPSGFMLTKDQERAI--KAMTPEQEE 485
            +L E ++  +    S  +        T+     Q+ +  +  K+  + +  K   P    
Sbjct: 1031 DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090

Query: 486  TASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQG 545
                L    +  +      SG   V   E  L  KE       L   C+   +   + +G
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL--KEADEMHTLLQLECEKYKSVLAETEG 1148

Query: 546  I---------------QIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELE------DF 584
            I               +++  E+   +K++Q     +  +LE+   + +++E      + 
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREH 1208

Query: 585  IKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR 644
            ++   E +  + S  V   +  + LL ELQ+ L  +  +   Q   L   + Q++E L +
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268

Query: 645  LQ-KDNDSLQGKHSLHVSLQQAE 666
            L+ + N+  +    LH + Q  E
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLE 1291



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 71/368 (19%), Positives = 161/368 (43%), Gaps = 44/368 (11%)

Query: 468 LTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGN 527
           L K  +  +  +  + +E   LL++V +       + +  R    T+  + +KE  N   
Sbjct: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKED-----AAATKDRCKQLTQEMMTEKERSNV-- 371

Query: 528 KLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQ 587
            + R  D     EK+    Q +   +  + +++Q+  +Q  +Q+E  +   ++    ++ 
Sbjct: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431

Query: 588 SSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQK 647
           +  ++++Q+ +     Q++E  L +L+Q  ++   ++ E+   L Q           +QK
Sbjct: 432 AVSNTTNQLES----KQSAE--LNKLRQDYARLVNELTEKTGKLQQE---------EVQK 476

Query: 648 DNDSLQGKHSLHVSLQQAE-------DFILPDTTE---ALRELVLKYREDIINVRTAADH 697
            N + Q    L V LQ+AE        +I   T E   A ++L  K+      V++    
Sbjct: 477 KN-AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSK 535

Query: 698 VEEKL--KAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEK 755
           + + L  K ++     Q+   +  + N EE+LQ+++++  E+     +LKA++++   + 
Sbjct: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ---NEALKAQIQQFHSQI 592

Query: 756 GQATVEQLMFEEKNKA------QRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLE 809
              T   ++ EE +K       Q  QTE  ++ +  R   K  +   +Q         ++
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652

Query: 810 RIRAILND 817
           +++A+ N+
Sbjct: 653 KLQALANE 660


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 75/372 (20%), Positives = 174/372 (46%), Gaps = 39/372 (10%)

Query: 15  QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHL 74
           ++++ E E    E +R Q++  +E  +K  + +E+   KEE ++RQ  ++   ++ +   
Sbjct: 374 EEKIQEQE----EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 429

Query: 75  RTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHL 134
              +WE + ++  ++      E  +++   E KRQ  E++   +   ++  + +  +  +
Sbjct: 430 EEMMWEKEEKIRELEEKMHEQEKIREQ---EEKRQEEEKIREQEKRQEQEAKMWRQEEKI 486

Query: 135 R------LEQERTQWAQYR----------ESAEREIADLRRRLSEGQEEENLENEMKKAQ 178
           R       EQE   W Q            E   +E  ++ R+  + +E+E +  + +K  
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIH 546

Query: 179 EDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
           E  EK+R      E+++   ++K+ + E+KI+E E    ++     E E+  R   E   
Sbjct: 547 EQEEKIRK----QEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK-- 600

Query: 239 AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
             +  Q+ + QE  EK+ ++  ++C   E+ ++Q  +++   +K  +Q  + +    +  
Sbjct: 601 --IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658

Query: 299 QRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESS 358
           ++ E++   E+    +E K  +QE+  Q++  K +  ++   E+E++      L Q+E  
Sbjct: 659 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR------LRQQEEK 712

Query: 359 AQLSNEEEHLDS 370
            Q    +EHL++
Sbjct: 713 MQ--EHQEHLEA 722



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 58/276 (21%), Positives = 135/276 (48%), Gaps = 19/276 (6%)

Query: 14  LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
           L++++ E EKI     R Q++  QE  +++ + +E    +E  + RQ   ++  ++ +  
Sbjct: 443 LEEKMHEQEKI-----REQEEKRQE--EEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495

Query: 74  LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
              ++W  +   E I     + E  K++  +E+ RQ  E++   + + ++  + +E +  
Sbjct: 496 QEEKMWRQE---EKIHEQEKIREEEKRQEQEEMWRQ-EEKIREQEEIWRQKEKIHEQEEK 551

Query: 134 LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLR---SVVMP 190
           +R +QE   W Q  +  ++E     +     ++EE +  + +K +E  EK+R    +   
Sbjct: 552 IR-KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610

Query: 191 MEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQE 250
            E+++   ++K+ E E+K++E E    ++     E EK  R   E     +  Q+ ++QE
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK----IREQEEMMQE 666

Query: 251 DAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQ 286
             EK+ ++  ++C   E+ ++Q  +++   +K  +Q
Sbjct: 667 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 702



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 83/366 (22%), Positives = 164/366 (44%), Gaps = 42/366 (11%)

Query: 20  ELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEE-DLKRQNAVLQAAQDDLG-HLRTQ 77
           EL++ NA+     Q +E E ++ +   KEL    E   L      LQA  D LG  L++ 
Sbjct: 279 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 338

Query: 78  LWEAQAEMENIKAIATVSENTKQEAI--DEVKRQWREEVASLQAVMKETVRDYEHQFHLR 135
             + QA++E  +    +++  +++    +E  ++W E++   +  ++E       Q    
Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 398

Query: 136 LEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPM-EKE 194
             QE   W       E+E    R+     ++EE +  + +   E  EK+R +   M E+E
Sbjct: 399 RRQEEMMW-------EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 451

Query: 195 IAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEK 254
               +++  + E+KI+E E  + +E   + + EK            +  Q+  ++E  EK
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK------------IREQEEKIREQEEK 499

Query: 255 L---RKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRM----EIVLTS 307
           +    +++HE   + E+E++Q  +    W++  ++ +  Q  + R  +++    E +   
Sbjct: 500 MWRQEEKIHEQEKIREEEKRQEQE--EMWRQ--EEKIREQEEIWRQKEKIHEQEEKIRKQ 555

Query: 308 EQLRQVEELKKKDQEDD--EQQRLNKRKDHKKADVEEEI-----KIPVVCALTQEESSAQ 360
           E+    +E K  DQE+   EQ+    R++ K  + EE+I     KI     +TQE+    
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM 615

Query: 361 LSNEEE 366
              EE+
Sbjct: 616 GEQEEK 621



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 123/644 (19%), Positives = 251/644 (38%), Gaps = 86/644 (13%)

Query: 65  QAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKET 124
           +  Q  L   + QL +   +     ++ T + +TK++ I+              +   E 
Sbjct: 115 ETRQSKLAEAKEQLTDHHPQTN--PSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQ 172

Query: 125 VRDYEHQFHLRLEQE--------------RTQWAQYR-----ESAEREIADLRRRLSEGQ 165
              ++HQ  LR E E                Q A Y      +  E E  DL  RL +  
Sbjct: 173 KASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSW 232

Query: 166 E-EENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKL---TEAEDKIKELEASKVKELN 221
           +    LE  +       +K    +  + KE  AL  +L   T  ++++KE  A K++E  
Sbjct: 233 KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA-KLQEKL 291

Query: 222 HYLEAEKS--------CRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQH 273
             +E+EKS         +  LE    +L  Q+  LQ +A+ L KEL  V   L Q + + 
Sbjct: 292 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQ--LQAEADHLGKELQSVSAKL-QAQVEE 348

Query: 274 NQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRK 333
           N+L   W + N Q  E        +Q  E  +  EQ  ++ E ++K +E +E+ R   R+
Sbjct: 349 NEL---WNRLNQQQEEKMWRQEEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMR---RQ 401

Query: 334 DHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKS 393
           +    + EE+++        +EE   ++  +EE +      +  L+  +           
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMMWEKEEKIRELEEKM----------H 448

Query: 394 DNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFD 453
           + +  ++   + Q  + +      Q +      + +     +E           + E  +
Sbjct: 449 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK----------IREQEE 498

Query: 454 TASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSET 513
                  ++     + ++++R  +     QEE       + +  E  +      R   E 
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK 558

Query: 514 EWNLLQKEVHNAGNKLGRRCDMCSNYEKQL----QGIQIQEAETRDQVKKLQLMLRQAND 569
            W   +K +H+   K+  + +     E+++    + I+ QE + R+Q +  Q    +  +
Sbjct: 559 MWRQEEK-MHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617

Query: 570 QLEKTMKDK---QELEDFIKQSSE----------DSSHQISALVLRAQASEILLEELQQG 616
           Q EK  + +   QE E+ +++  E          +   +I       Q  E  + E ++ 
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677

Query: 617 LSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHV 660
           + + +  +QEQ   + +  E++ E+ VRL++  + +Q +H  H+
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ-EHQEHL 720



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 38/174 (21%), Positives = 77/174 (44%), Gaps = 27/174 (15%)

Query: 22  EKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEA 81
           EKI  +  +  +Q E++  ++  K +E    +EE ++ Q  + Q  ++ +G    ++ E 
Sbjct: 571 EKIREQEEKVWRQ-EEKIREQEEKIRE----QEEKIREQEEMTQEQEEKMGEQEEKMCEQ 625

Query: 82  QAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERT 141
           + +M              QE  ++++RQ  E++   +  ++E       Q  +  EQE  
Sbjct: 626 EEKM--------------QEQEEKMRRQ-EEKIREQEKKIREQEEKIREQEEMMQEQEEK 670

Query: 142 QWAQYRESAEREIA------DLRRRLSEGQEEE-NLENEMKKAQEDAEKLRSVV 188
            W Q  +  E+E         +RR+  +  E+E  L  + +K QE  E L + +
Sbjct: 671 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 42/288 (14%), Positives = 129/288 (44%), Gaps = 11/288 (3%)

Query: 528 KLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQ 587
           K+ R+ +M    E++++  +    E  +++++L+  + +     E+  K ++E +   ++
Sbjct: 411 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 470

Query: 588 SSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVR--- 644
             ++   ++     + +  E  + E ++ + + +  + EQ  +  + + Q  EE+ R   
Sbjct: 471 KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 530

Query: 645 -LQKDNDSLQGKHSLH-----VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHV 698
            +++  +  + K  +H     +  Q+ + +   +      E + +  E +          
Sbjct: 531 KIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ 590

Query: 699 EEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
           EEK++ +   ++EQ +  Q  +E + E  +   E  ++       ++ + E+I+ ++ + 
Sbjct: 591 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKI 650

Query: 759 TVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQAD 806
             ++    E+ +  + Q E  + EQ ++   +  + +Q Q E++R+ +
Sbjct: 651 REQEEKIREQEEMMQEQEE-KMWEQEEK-MCEQEEKMQEQEEKMRRQE 696



 Score = 33.5 bits (75), Expect = 0.83
 Identities = 54/203 (26%), Positives = 93/203 (45%), Gaps = 18/203 (8%)

Query: 619 QAKRDVQEQMAVLMQSREQVSE-ELVRLQKDNDSLQGKHSLHVSLQ---QAEDFI--LPD 672
           + K   Q Q A+  +   QV    ++  QK    +   +S H   Q   +A D I  L D
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 230

Query: 673 TTEALRELVLKYREDIINVRTAADHVEEKLK---AEILFLKEQIQAEQCLKEN---LEET 726
           + +   EL           + A  ++EE  K   A  L L      ++ LKE    L+E 
Sbjct: 231 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEK 290

Query: 727 LQLEIENCKEEIA-SISSLKAELERIKV----EKGQATVEQLMFEEKNKAQRLQTELDVS 781
           LQL +E+ K EI  ++  LK +LER K+    ++ QA  + L  E ++ + +LQ +++ +
Sbjct: 291 LQL-VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 349

Query: 782 EQVQRDFVKLSQTLQVQLERIRQ 804
           E   R   +  + +  Q E+I++
Sbjct: 350 ELWNRLNQQQEEKMWRQEEKIQE 372


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 176/839 (20%), Positives = 329/839 (39%), Gaps = 73/839 (8%)

Query: 14   LQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH 73
            LQ+   +L K+  + LR ++Q E++  Q+        L +E+ L+R+    +  Q +   
Sbjct: 271  LQEEEEQLRKLERQELRRERQEEEQQQQR--------LRREQQLRRKQEEERREQQEERR 322

Query: 74   LRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFH 133
             + +  E Q E    +      E  +Q+   E + + RE+    +   +   +    +  
Sbjct: 323  EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 134  LRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEK 193
            LR EQ+  +  Q R   +       RR  + + E+ L  E +  +E  E+        E+
Sbjct: 383  LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 194  EIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD--LEMYVAVLNTQKSVLQED 251
                LK +  E  D +K  E ++  E     +  K  + +   E ++ +   ++   QE 
Sbjct: 443  REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502

Query: 252  AE-KLRKE----------LHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
             E +LR+E            E    L+Q  +   QL+   ++  +Q L+ +     + +R
Sbjct: 503  REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562

Query: 301  MEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQ 360
             E  L  EQ  + ++L K+ +E+  QQRL + ++ +   +E+ +K   V  L QEE   Q
Sbjct: 563  REQRLKREQEERRDQLLKR-EEERRQQRLKREQEER---LEQRLKREEVERLEQEERREQ 618

Query: 361  LSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGL-RRAQSTDSLGTSGSLQS 419
                EE  +  R          LL S +   +    + ++   RR Q          L+ 
Sbjct: 619  RLKREEPEEERRQQ--------LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670

Query: 420  KALGYNYKAKSAGNLDESD---FGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAI 476
            +    + + +    L E +       + +      +   S    +    +   + QE   
Sbjct: 671  RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQR 730

Query: 477  KAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAG-NKLGRRCDM 535
            +    E++          Q  E A+          +  W    +E    G  +L  R  +
Sbjct: 731  RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790

Query: 536  CSNYEKQLQGIQIQEAE----------------TRDQVKKLQLMLRQANDQLEKTMKDKQ 579
                E+QL+  + Q+ E                 R++ K+LQ +  +   Q  +  +  Q
Sbjct: 791  REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850

Query: 580  ELEDFIKQSSEDSSHQISALVLRAQASEILLEE---LQQGLSQAKRDVQEQMAVLMQSRE 636
            E ED ++   ED   + S    R Q     LEE    ++    AK  +QEQ+    Q  +
Sbjct: 851  EEEDGLQ---EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907

Query: 637  QVSEELVRLQKDNDSLQGKHSLH---VSLQQAEDFILPDTTEALR--ELVLKYREDIINV 691
            +  EEL R +++    Q +   +     LQQ E+ +L +  E  R  E   +YR+D    
Sbjct: 908  EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD---- 963

Query: 692  RTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERI 751
                   EE+L  E    + + + E+  +E  EE  Q E +  +EE       + E +  
Sbjct: 964  -KKLQQKEEQLLGEEPEKRRRQEREKKYREE-EELQQEEEQLLREEREKRRRQEWERQYR 1021

Query: 752  KVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLER 810
            K ++ Q   EQL+ EE+ K +RLQ E +   + + +  +  + L  +    R+   LER
Sbjct: 1022 KKDELQQEEEQLLREEREK-RRLQ-ERERQYREEEELQQEEEQLLGEERETRRRQELER 1078



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 92/345 (26%), Positives = 157/345 (45%), Gaps = 36/345 (10%)

Query: 15   QQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL-YLAKEEDLKRQNAVLQAAQDDLG- 72
            Q R  E ++    FL  +++ EQ   Q+R + KEL +L +EE L+R+    Q  +++ G 
Sbjct: 797  QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856

Query: 73   -----------HLRTQLWEAQAEMENIKAIATV-SENTKQEAIDEVKRQWREEVASLQAV 120
                         R Q W  Q E E  +   T+ ++   QE + + ++  +EE   LQ  
Sbjct: 857  QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 121  MKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQED 180
             +E  R  E +   R  +E  Q  Q  E   RE  + RRR    QE E    + KK Q+ 
Sbjct: 917  EREKRRRQEQE---RQYREEEQLQQEEEQLLREEREKRRR----QERERQYRKDKKLQQK 969

Query: 181  AEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV 240
             E+L  +    EK     ++K    E+++++ E   ++E     E EK  R + E     
Sbjct: 970  EEQL--LGEEPEKRRRQEREKKYREEEELQQEEEQLLRE-----EREKRRRQEWERQY-- 1020

Query: 241  LNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQR 300
               +K  LQ++ E+L +E  E   L E+ERQ   +     Q+  +Q L  +R   R  + 
Sbjct: 1021 --RKKDELQQEEEQLLREEREKRRLQERERQYREE--EELQQEEEQLLGEERETRRRQEL 1076

Query: 301  MEIVLTSEQLRQVEE--LKKKDQEDDEQQRLNKRKDHKKADVEEE 343
                   E+L+Q EE  L+++ ++   Q+R  + ++ ++   EEE
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 179/878 (20%), Positives = 345/878 (39%), Gaps = 134/878 (15%)

Query: 15   QQRVAELEKINAEFLRAQQQL---EQEFNQKRAKFKELYLAKEEDLKRQN----AVLQAA 67
            ++R  +L K   +  R QQQL   +QE  ++R K +E     E+ LKR++       + A
Sbjct: 627  EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686

Query: 68   QDDLGHLRTQL------W------EAQAEMENIKAIATVSENTKQEAIDEVKR------- 108
            +++    R ++      W      EA A    + +     E  ++    E KR       
Sbjct: 687  EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746

Query: 109  QWREEV-ASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEE 167
            QW+EE  A  Q   +E  RD+  Q+     +E+++  + R SA   + + R R    +E 
Sbjct: 747  QWQEEERAHRQQQEEEQRRDFTWQWQ---AEEKSERGRQRLSARPPLREQRERQLRAEER 803

Query: 168  ENLENEMKKAQEDAEKLRSVVMPMEKEIAALKD-----------KLTEAEDKIKE----- 211
            +  E      +E+ E+ R      EKE+  L++           +L E ED ++E     
Sbjct: 804  QQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR 863

Query: 212  --LEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQ----KSVLQEDAEKLRKELHEVCHL 265
               E  + ++    LE E+  R         L  Q    + +LQE+ E+L++E  E    
Sbjct: 864  RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR 923

Query: 266  LEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEE--LKKKDQED 323
             EQERQ   +     Q+  +Q L  +R   R  +R       ++L+Q EE  L ++ ++ 
Sbjct: 924  QEQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981

Query: 324  DEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL 383
              Q+R  K ++ ++   EEE        L +EE   +   E E     +  +   +  LL
Sbjct: 982  RRQEREKKYREEEELQQEEE-------QLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034

Query: 384  LPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV 443
                    + +    ++  R+ +  + L      + + LG   + +    L+        
Sbjct: 1035 R------EEREKRRLQERERQYREEEELQQE---EEQLLGEERETRRRQELERQ------ 1079

Query: 444  GADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSV-----TQGME 498
                  E         L+        +++ER  +     Q+E   LL         Q +E
Sbjct: 1080 --YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137

Query: 499  SAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETR-DQV 557
              Y        V + E  LL++E         RR ++   Y ++ +  Q +E   R +Q 
Sbjct: 1138 RQYREEEE---VQQEEEQLLREEPEKR-----RRQELERQYREEEELQQEEEQLLREEQE 1189

Query: 558  KKLQLMLRQANDQLE-KTMKDKQELED------------------------FIKQSSEDS 592
            K+ Q   RQ  ++ E +  K KQ   D                        + K    + 
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQ 1249

Query: 593  SHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSL 652
              Q+    LR + S+   ++LQ  L + +   +EQ     Q R++   E  +L+++    
Sbjct: 1250 FRQLEDSQLRDRQSQ---QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREE--- 1303

Query: 653  QGKHSLHVSLQQAEDFILPDTTEALR---ELVLKYREDIINVRTAADHVEEKLKAEILFL 709
            Q +        Q E  +L +  E  R   E   K+RE+   ++   +    + + +  F 
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363

Query: 710  KEQIQAEQCLKENLEETLQLEIEN------CKEEIASISSLKAELERIKVEKGQATVEQL 763
            +E+++ ++  ++ LEE  +L  +        +E+       + +L + +  K +   +QL
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423

Query: 764  MFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLER 801
              +E+++  R + +    ++ +R F++  Q L+ +  R
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 79/352 (22%), Positives = 157/352 (44%), Gaps = 28/352 (7%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQ 68
            +P+   +Q +    +   E  + ++QL +E  +KR + +E    +EE+L+RQ    +   
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD 1216

Query: 69   DDLGHLRTQL-WEAQAEMENI----KAIATVSENTKQEAIDEVKRQWREEVASLQAVMKE 123
            +D    R+ L W+ + E EN     K      EN +   +++ + + R+    LQ ++ E
Sbjct: 1217 ED---QRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENL----ENEMKKAQE 179
                   Q   R +Q    + +  +    E  + +RR  + QEE+ L      E ++ QE
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333

Query: 180  DAEKLR-SVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYV 238
               K R    +  E+E   L+ +  E + K +E E    ++   +LE E+  R       
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQ--ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391

Query: 239  AVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDM 298
             +   Q+   QE  ++LR++         + R++  QL    Q+ + +F E ++ + R  
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRD------RKFREEEQQLSR--QERDRKFREEEQQVRRQE 1443

Query: 299  QRMEIVLTSEQLRQVEELKKKD-----QEDDEQQRLNKRKDHKKADVEEEIK 345
            +  + +   +QLRQ    K ++     QE +EQQ   + +D K  + E++++
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 139/790 (17%), Positives = 328/790 (41%), Gaps = 60/790 (7%)

Query: 33  QQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIA 92
           Q   QE +Q+R + ++  L +E   +R+    Q  Q+       +L E + + E  + + 
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRR----QKRQEQ----ERELAEGEEQSEKQERLE 162

Query: 93  TVSENTKQEAIDEVKRQWRE------EVASLQAVMKETVRDYEHQFHLRLEQERTQWAQY 146
                 + E +   +++W+E      E   LQ+       ++  +  LR  +      + 
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 147 RESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAE 206
           RE  +++  + + R+ + +EE+         +++ EKL+      ++E+   +++L + E
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 207 DKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLL 266
            +    E  + ++    L  E+  R   E        ++   QE  E+ ++E  E     
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQ-QEERREQQLRR 341

Query: 267 EQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSE-QLRQVEELKKKDQEDDE 325
           EQE ++  QL+   ++  ++  E Q    ++ +R E  L  E QLR+ ++L+++ Q   E
Sbjct: 342 EQEERREQQLR---REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398

Query: 326 QQRLNKRKDHKKADV--EEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLL 383
           QQ   +++  ++  +  E++++        QEE   +  +E+E  +  R      +    
Sbjct: 399 QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ-RLKREQEERRDW 457

Query: 384 LPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLV 443
           L   +   + + +  K  L+R Q  +       L+ +      + +      E +     
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE----E 513

Query: 444 GADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVS 503
             +   +  +       ++ S   L ++QE   + +   +EE         + +E     
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE---------KRLEQERRE 564

Query: 504 PSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLM 563
               R   E    LL++E      +L R  +     E+  Q ++ +E E  +Q ++ +  
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQE-----ERLEQRLKREEVERLEQEERREQR 619

Query: 564 LRQANDQLEK---TMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQA 620
           L++   + E+    +K +++ E   +Q   +   +    + R +  E L + L++   + 
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679

Query: 621 KRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALREL 680
           +R+ +       Q+RE++   + + Q   +S           +Q++ +  P   E  R  
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLES-------EADARQSKVYSRPRKQEGQRR- 731

Query: 681 VLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIAS 740
             + +E+    R +    +E+ +A     ++Q + EQ      +   + + E  ++ +++
Sbjct: 732 -RQEQEEKRRRRESELQWQEEERAH----RQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786

Query: 741 ISSLKAELER-IKVEKGQATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQL 799
              L+ + ER ++ E+ Q   ++ + EE+ K QR +   +  +++Q  F++  + LQ + 
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ--FLEEEEQLQ-RR 843

Query: 800 ERIRQADSLE 809
           ER +Q    E
Sbjct: 844 ERAQQLQEEE 853



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 78/348 (22%), Positives = 159/348 (45%), Gaps = 37/348 (10%)

Query: 27   EFLRAQQQLE-QEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGH-LRTQLWEAQAE 84
            +FL+ +QQL  QE  Q+R + ++    +EE L+++    Q ++ +     R +  + + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 85   MENIKAIATVSENTKQEAIDEVK----RQWREEVASLQAVMKETVRDYEHQFHLRLEQER 140
             +  K +    +  +QE   +++    R++RE+   LQ   ++ +   E      LE+E 
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF-LEEEP 1650

Query: 141  TQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKD 200
                Q RE   R   D + R  E   +E  E ++++ + D  K R     + ++      
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD-RKFREEEQQLRRQ------ 1703

Query: 201  KLTEAEDK-IKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKEL 259
               E E K ++E +  + +EL      E+  R + E        Q+ + ++  E+ RK L
Sbjct: 1704 ---ERERKFLQEEQQLRRQELERKFREEEQLRQETE--------QEQLRRQ--ERYRKIL 1750

Query: 260  HEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLM-RDMQRMEIVLTSEQLRQVEELKK 318
             E     EQ R +  + +   Q+ + +F E ++L   R+ Q++    +  + R+ E+L+ 
Sbjct: 1751 EE-----EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR- 1804

Query: 319  KDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
              QE +EQQ   +++D K    EE++++       ++E   Q   EE+
Sbjct: 1805 --QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 77/366 (21%), Positives = 153/366 (41%), Gaps = 45/366 (12%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEED-LKRQNAVLQAA 67
            Q +   + R ++ EK      R +++  QE ++K  + ++L   +EE  L+RQ    +  
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363

Query: 68   QDDLGHLRT---------QLWEAQAEMENIKAIATVS-ENTKQEAIDEVKRQWREEVASL 117
            +++L H            +L   + E + +K    +  +  +Q+   +  R++REE   L
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423

Query: 118  QAVMKETVRDYEHQFHLRLEQERT---QWAQYRESAEREIADLRRRLSEGQEEENLENEM 174
                ++     E Q   R E+ER    +  Q R+   R+  +  + L E +E++    E 
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483

Query: 175  -KKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD 233
             +K  E+ ++LR                  E + K +E E    +    +LE E+     
Sbjct: 1484 DRKFLEEEQQLRR----------------QERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527

Query: 234  LEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQF------ 287
                  +   Q+   QE  ++ R++        EQ RQ+  + + + Q+ + +F      
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 288  ---LESQRLLMRDMQRMEIVLTSEQLRQVEELKKKD-----QEDDEQQRLNKRKDHKKAD 339
                E +R  M D Q++      +QLRQ  + K ++     QE +EQQ   + +D K  +
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 340  VEEEIK 345
             E +++
Sbjct: 1648 EEPQLR 1653



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 62/276 (22%), Positives = 123/276 (44%), Gaps = 26/276 (9%)

Query: 103 IDEVKRQWREEVASL--QAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRR 160
           +DE KR   +   SL      +E  R +E +     E+   +  Q R+  ERE+A     
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA----- 149

Query: 161 LSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKEL 220
             EG+E+   E + +  Q D ++    +    +E    +++  E E    +L++ K  E 
Sbjct: 150 --EGEEQS--EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE----QLQSCKGHET 201

Query: 221 NHYLEAEKSCRTDL---------EMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQ 271
             + + E+  R +L         E        Q  V QE+ EK  ++   V    E++ Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261

Query: 272 QHN-QLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLN 330
           +   Q +   Q+  +Q  + +R  +R  +R E     ++LR+ ++L++K +E+  +Q+  
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELR-RERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320

Query: 331 KRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEE 366
           +R+  ++ + +EE +   +    +E    QL  E+E
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQE 356



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 61/286 (21%), Positives = 122/286 (42%), Gaps = 25/286 (8%)

Query: 9    QPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKEL---YLAKEEDLKRQNAVLQ 65
            +P +  Q+R  +L        R ++QL QE  +++ + +E    +  +E+ L+RQ    +
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708

Query: 66   AAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEV--KRQWREEVASLQAVMKE 123
              Q++    R +L     E E ++      +  +QE   ++  + Q R E    Q   +E
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768

Query: 124  TVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEK 183
              R +  +  LR E+E  Q     + ++R+  +   +L + +EE+ L  + +  +   E+
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRS--QESDRKFRE-EEQLRQEREEQQLRPQQRDGKYRWEE 1825

Query: 184  LRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNT 243
             +  +   E+ +   +D+   AE++    E S+ +E   + E E+  R            
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR------------ 1873

Query: 244  QKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLE 289
                 QE   KLR+E        EQ  +Q  ++K    K + + LE
Sbjct: 1874 -----QERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 77/391 (19%), Positives = 158/391 (40%), Gaps = 56/391 (14%)

Query: 23   KINAEFLRAQQQ----LEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQL 78
            K   E LR Q+Q    LE+E   +R + +  +L +E+ L+ Q    Q  QD     R   
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR--- 1417

Query: 79   WEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQ 138
             E + ++   +      E  +Q    E +R++ EE   L+       R+ E     +L Q
Sbjct: 1418 -EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE-----QLLQ 1471

Query: 139  ERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAAL 198
            ER +   +R+  +R+  +  ++L   + +     +  ++QE   K       + ++    
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531

Query: 199  KDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTD----------------LEMYVAVLN 242
            K    E + + +E    + ++ +     E+  R +                LE       
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591

Query: 243  TQKSVLQEDAEKLRKELHEVCHLLEQER-----------QQHNQLKHTWQKANDQFLESQ 291
             Q+    ED ++LR++  E    L QER           Q+  + +   Q+ + +FLE +
Sbjct: 1592 EQERKFMEDEQQLRRQ--EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649

Query: 292  RLLMRDMQRMEI-------VLTSEQLRQV---EELKKKDQE----DDEQQRLNKRKDHKK 337
              L R  +  ++           EQL Q    ++L++++++    ++EQQ   + ++ K 
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709

Query: 338  ADVEEEIKIPVVCALTQEESSAQLSNEEEHL 368
               E++++   +    +EE   +   E+E L
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQL 1740



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 83/370 (22%), Positives = 147/370 (39%), Gaps = 54/370 (14%)

Query: 29   LRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENI 88
            L  QQ+ ++E  ++R + ++ +  +EE L+R+       +D       QL   + E +  
Sbjct: 1271 LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR 1330

Query: 89   KAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRE 148
            +               E  R++REE   LQ   ++ +R  E     R E+ R Q  Q R+
Sbjct: 1331 R--------------QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ-EQGRK 1375

Query: 149  SAEREIADLRRR------LSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKL 202
              E E   LRR+      L E Q+    E E +  Q+   K R     + ++    K + 
Sbjct: 1376 FLEEE-QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434

Query: 203  TEAEDKIKELEASKVKELNH--------YLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEK 254
             E + + +E E   ++E           + E E+  +   E  +      +  L+E+ + 
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494

Query: 255  LRKELHEVCH------------LLEQERQQHNQLK-HTWQKANDQFLESQRLLMRDMQRM 301
             R+E                   LE+E+Q H Q +   + +   Q    +R   R   R 
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554

Query: 302  EIVLTSEQLRQV-EELKKKDQEDDEQQRLN----KRKDHKKADVEEEIKIPVVCALTQEE 356
                  EQLRQ  EE +   QE D + RL     +R++ ++  +E+E +      L ++E
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ------LRRQE 1608

Query: 357  SSAQLSNEEE 366
               QL  E +
Sbjct: 1609 GQQQLRQERD 1618



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 61/268 (22%), Positives = 116/268 (43%), Gaps = 29/268 (10%)

Query: 29   LRAQQQLEQEFNQKRAKFKE----LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAE 84
            LR Q++ +Q  + +  KF+E    L   +E+ L+RQ    +  +++   LR Q  E +  
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ-QLRRQERERKFL 1710

Query: 85   MENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWA 144
             E            +Q    E++R++REE    Q   +E +R  E ++   LE+E+ +  
Sbjct: 1711 QEE-----------QQLRRQELERKFREEEQLRQETEQEQLRRQE-RYRKILEEEQLRPE 1758

Query: 145  QYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTE 204
            +  +   R+  D + R  E   +E  E +++  + D +      +  E+E   L+ +  +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818

Query: 205  AEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCH 264
             + + +E E  +++E    L  E+  +   E   A             EK R+E  E+  
Sbjct: 1819 GKYRWEE-EQLQLEEQEQRLRQERDRQYRAEEQFAT-----------QEKSRREEQELWQ 1866

Query: 265  LLEQERQQHNQLKHTWQKANDQFLESQR 292
              EQ+R+Q  + K   +    Q  E QR
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 59/276 (21%), Positives = 128/276 (46%), Gaps = 20/276 (7%)

Query: 540 EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL 599
           E++ + ++++E E R+Q ++ +  LR+  ++  +    +QE E+ ++Q     S Q    
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR--SEQQLRR 540

Query: 600 VLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLH 659
               +  ++L  E ++ L Q +R+ +     L + +E+  ++L++ +++    + K    
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQR-----LKREQEERRDQLLKREEERRQQRLKREQE 595

Query: 660 VSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQ-AEQC 718
             L+Q    +  +  E L +      E+    R   +  EE+ + ++L  +EQ +  +Q 
Sbjct: 596 ERLEQR---LKREEVERLEQ------EERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 719 LKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEE--KNKAQRLQT 776
           L+   +E  +  ++  +EE      LK E E  + E+  A  EQ    E  K++  + Q 
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706

Query: 777 ELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIR 812
           +L+ SE   R     S+  + + +R RQ    +R R
Sbjct: 707 QLE-SEADARQSKVYSRPRKQEGQRRRQEQEEKRRR 741



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 63/304 (20%), Positives = 137/304 (45%), Gaps = 26/304 (8%)

Query: 547  QIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQAS 606
            Q+++   R   ++ QL+  +   QL +  +D++ LE+  +   ++   +     LR+Q  
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513

Query: 607  EILLEELQQGLSQAKRD---VQEQMAVLMQSR-EQVSEELVRLQKDNDSL-QGKHSLHVS 661
            E    E +Q L + +R    +QE+  +  Q R +Q  ++  R  ++ + L Q +    +S
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573

Query: 662  LQQAE-DFILPDTTEALRELVLKYREDIINVR------TAADHVEEKLKAEILFLKE--- 711
             Q+ +  F L +     +E   K+ ED   +R            + K + +   L+E   
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633

Query: 712  -QIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQATVEQLMFEEKNK 770
             Q+  ++  ++ LEE  QL  +  ++++      K   E   +++G+   +QL  +E+++
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE--QQLRRQERDR 1691

Query: 771  AQRLQTELDVSEQVQRDFVKLSQTLQVQ--------LERIRQADSLERIRAILNDTKLTD 822
              R + +    ++ +R F++  Q L+ Q         E++RQ    E++R      K+ +
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751

Query: 823  INQL 826
              QL
Sbjct: 1752 EEQL 1755



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 55/265 (20%), Positives = 112/265 (42%), Gaps = 32/265 (12%)

Query: 540  EKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISAL 599
            E++ Q +  QE + +   ++ QL  ++   QL      K   E+ + Q  E+        
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ------ 1683

Query: 600  VLRAQASEILLEELQQGLSQAKRD---VQEQMAVLMQSREQVSEELVRLQKDNDSLQGKH 656
             LR Q  +    E +Q L + +R+   +QE+  +  Q  E+   E  +L+++ +  Q + 
Sbjct: 1684 -LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742

Query: 657  SLHVSLQQAEDFILPDTTEAL---RELVLKYREDIINVRTAADHVEEKLKAEILFLK--- 710
                     E+ + P+  E     +E   K+RE+    +   +  E++L+++    K   
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREE---EQLRQEREEQQLRSQESDRKFRE 1799

Query: 711  ----EQIQAEQCLKENL--------EETLQLEIENCKEEIASISSLKAELERIKVEKGQA 758
                 Q + EQ L+           EE LQLE +  +         +AE E+   ++   
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE-EQFATQEKSR 1858

Query: 759  TVEQLMFEEKNKAQRLQTELDVSEQ 783
              EQ +++E+ + +R + E  + E+
Sbjct: 1859 REEQELWQEEEQKRRQERERKLREE 1883


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,397,018
Number of Sequences: 37866
Number of extensions: 1231394
Number of successful extensions: 18691
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 343
Number of HSP's successfully gapped in prelim test: 1202
Number of HSP's that attempted gapping in prelim test: 7520
Number of HSP's gapped (non-prelim): 6805
length of query: 829
length of database: 18,247,518
effective HSP length: 111
effective length of query: 718
effective length of database: 14,044,392
effective search space: 10083873456
effective search space used: 10083873456
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.