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Search of human proteins with 5579478
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5579478 mitogen-activated protein kinase kinase 1 [Homo
sapiens]
(393 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 790 0.0
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 637 0.0
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 263 3e-70
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 246 3e-65
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 218 1e-56
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 209 3e-54
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 209 3e-54
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 206 3e-53
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 200 2e-51
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 179 5e-45
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 171 1e-42
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 161 8e-40
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 155 5e-38
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 154 1e-37
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 154 1e-37
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 153 3e-37
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 144 1e-34
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 132 5e-31
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 131 1e-30
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 129 5e-30
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 129 5e-30
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 129 5e-30
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 129 5e-30
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 129 5e-30
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 129 5e-30
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 129 5e-30
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 129 5e-30
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 128 1e-29
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 128 1e-29
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 126 3e-29
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 790 bits (2040), Expect = 0.0
Identities = 393/393 (100%), Positives = 393/393 (100%)
Query: 1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 60
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
Sbjct: 1 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 60
Query: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
Sbjct: 61 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 120
Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
Sbjct: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 180
Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 240
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
Sbjct: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 240
Query: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
Sbjct: 241 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 300
Query: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
Sbjct: 301 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360
Query: 361 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Sbjct: 361 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 393
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 637 bits (1644), Expect = 0.0
Identities = 319/398 (80%), Positives = 349/398 (87%), Gaps = 7/398 (1%)
Query: 1 MPKKKPT--PIQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQK 57
+ ++KP + +NP +G + ++E NL LQKKLEELELDEQQ+KRLEAFLTQK
Sbjct: 2 LARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQK 61
Query: 58 QKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV 117
KVGELKDDDFE+ISELGAGNGGVV KV H+PSGL+MARKLIHLEIKPAIRNQIIRELQV
Sbjct: 62 AKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV 121
Query: 118 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 177
LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK+A RIPE+ILGKVSIAV++GL
Sbjct: 122 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGL 181
Query: 178 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG 237
YLREKH+IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYM+PERLQG
Sbjct: 182 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG 241
Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPRPRTP 293
THYSVQSDIWSMGLSLVE+AVGRYPIPPPDAKELE +FG V EG+ PRPR P
Sbjct: 242 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPP 301
Query: 294 GRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK 353
GRP+S +GMDSRP MAIFELLDYIVNEPPPKLP+GVF+ +FQ+FVNKCLIKNPAERADLK
Sbjct: 302 GRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLK 361
Query: 354 QLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAA 391
L H FIKRS+ EEVDFAGWLC T+ LNQP TPT A
Sbjct: 362 MLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTA 399
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 263 bits (671), Expect = 3e-70
Identities = 142/339 (41%), Positives = 204/339 (60%), Gaps = 41/339 (12%)
Query: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL 101
L K+ A L + G++ + D LG GNGG V+K H PSG ++A K+I L
Sbjct: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD K +
Sbjct: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----M 255
Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221
PE +LG++++AV+KGLTYL KI+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
Query: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281
++VGT +YM+PER+ G Y + SD+WS+G+S +E+A+GR+P P + LM
Sbjct: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLM------- 367
Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341
PL +LL IV+E P LP G FS F F+ +C
Sbjct: 368 --------------PL--------------QLLQCIVDEDSPVLPVGEFSEPFVHFITQC 399
Query: 342 LIKNPAERADLKQLMVHAFIKR-SDAEEVDFAGWLCSTI 379
+ K P ER ++LM H FI + +D + W+C +
Sbjct: 400 MRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRAL 438
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 246 bits (627), Expect = 3e-65
Identities = 134/339 (39%), Positives = 195/339 (57%), Gaps = 51/339 (15%)
Query: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL 101
L K+ A L + G++ + D LG GNGG V+K H PSG ++A K+I L
Sbjct: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
Query: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD K +
Sbjct: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----M 255
Query: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221
PE +LG++++AV+KGLTYL KI+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
Query: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281
++VGT +YM+PER+ G Y + SD+WS+G+S +E+ + + P
Sbjct: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMP---------------- 358
Query: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341
+LL IV+E P LP G FS F F+ +C
Sbjct: 359 -----------------------------LQLLQCIVDEDSPVLPVGEFSEPFVHFITQC 389
Query: 342 LIKNPAERADLKQLMVHAFIKR-SDAEEVDFAGWLCSTI 379
+ K P ER ++LM H FI + +D + W+C +
Sbjct: 390 MRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRAL 428
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 218 bits (554), Expect = 1e-56
Identities = 125/329 (37%), Positives = 187/329 (56%), Gaps = 52/329 (15%)
Query: 62 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 120
E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + +
Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106
Query: 121 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 176
+ P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K
Sbjct: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165
Query: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER- 234
L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER
Sbjct: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225
Query: 235 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
L YSV+SDIWS+G++++E+A+ R+P D+ TP
Sbjct: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPY------------------DSWGTP---- 263
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
F+ L +V EP P+LP+ FS EF DF ++CL KN ER
Sbjct: 264 -------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304
Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380
+LM H F +++ D A ++ +G
Sbjct: 305 YPELMQHPFFTLHESKGTDVASFVKLILG 333
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 209 bits (533), Expect = 3e-54
Identities = 124/338 (36%), Positives = 187/338 (55%), Gaps = 52/338 (15%)
Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112
F+T + E++ DD ISELG G GVV KV H SG +MA K I + + +++
Sbjct: 20 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 79
Query: 113 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILG 167
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG
Sbjct: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 138
Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226
++++++++ L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 139 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 198
Query: 227 RSYMSPER----LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282
+ YM+PER L Y+V+SD+WS+G++++EMA+ R+P +
Sbjct: 199 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY------------------E 240
Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342
+ TP F+ L +V EP P+LP+ FS EF DF +CL
Sbjct: 241 SWGTP-----------------------FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCL 277
Query: 343 IKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380
KNPAER +LM H F ++ D A ++ +G
Sbjct: 278 RKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILG 315
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 209 bits (533), Expect = 3e-54
Identities = 124/338 (36%), Positives = 187/338 (55%), Gaps = 52/338 (15%)
Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112
F+T + E++ DD ISELG G GVV KV H SG +MA K I + + +++
Sbjct: 49 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 108
Query: 113 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILG 167
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG
Sbjct: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 167
Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226
++++++++ L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G
Sbjct: 168 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGC 227
Query: 227 RSYMSPER----LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGD 282
+ YM+PER L Y+V+SD+WS+G++++EMA+ R+P +
Sbjct: 228 KPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPY------------------E 269
Query: 283 AAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL 342
+ TP F+ L +V EP P+LP+ FS EF DF +CL
Sbjct: 270 SWGTP-----------------------FQQLKQVVEEPSPQLPADRFSPEFVDFTAQCL 306
Query: 343 IKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 380
KNPAER +LM H F ++ D A ++ +G
Sbjct: 307 RKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILG 344
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 206 bits (524), Expect = 3e-53
Identities = 126/354 (35%), Positives = 200/354 (56%), Gaps = 59/354 (16%)
Query: 35 KKLEELELDE--QQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGL 92
+ +E +E+D+ Q+ + +LT + + + +D E + E+G+G G V+K+ + +G
Sbjct: 85 RSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGH 144
Query: 93 VMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGAFYSDGEISICMEHMDGG 149
V+A K + +I+ +L V+ H+C PYIV +G F ++ ++ I ME M G
Sbjct: 145 VIAVKQMRRSGNKEENKRILMDLDVVLKSHDC--PYIVQCFGTFITNTDVFIAMELM--G 200
Query: 150 SLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLC 207
+ + LKK G IPE+ILGK+++A++K L YL+EKH ++HRDVKPSNIL++ RG+IKLC
Sbjct: 201 TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLC 260
Query: 208 DFGVSGQLIDSMANS-FVGTRSYMSPERLQ-----GTHYSVQSDIWSMGLSLVEMAVGRY 261
DFG+SG+L+DS A + G +YM+PER+ Y +++D+WS+G+SLVE+A G++
Sbjct: 261 DFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQF 320
Query: 262 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP 321
P C+ + FE+L ++ E
Sbjct: 321 PYK-----------NCKTD------------------------------FEVLTKVLQEE 339
Query: 322 PPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 374
PP LP + FS +FQ FV CL K+ +R +L+ H+FIKR + EVD A W
Sbjct: 340 PPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASW 393
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 200 bits (509), Expect = 2e-51
Identities = 122/337 (36%), Positives = 184/337 (54%), Gaps = 57/337 (16%)
Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSP 124
+D + + E+G G G V K+ HKPSG +MA K I + + Q++ +L V + + P
Sbjct: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-----IPEQILGKVSIAVIKGLTY 179
YIV FYGA + +G+ ICME M S D+ K IPE+ILGK+++A +K L +
Sbjct: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
Query: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERLQGT 238
L+E KI+HRD+KPSNIL++ G IKLCDFG+SGQL+DS+A + G R YM+PER+ +
Sbjct: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
Query: 239 ----HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294
Y V+SD+WS+G++L E+A GR+P P +
Sbjct: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWN--------------------------- 311
Query: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG---VFSLEFQDFVNKCLIKNPAERAD 351
++F+ L +V PP+L + FS F +FVN CL K+ ++R
Sbjct: 312 --------------SVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPK 357
Query: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPT 388
K+L+ H FI + V+ A ++C + P+TP+
Sbjct: 358 YKELLKHPFILMYEERAVEVACYVCKILD-QMPATPS 393
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 179 bits (453), Expect = 5e-45
Identities = 111/319 (34%), Positives = 173/319 (54%), Gaps = 56/319 (17%)
Query: 57 KQKVGELKDDD--------FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIR 108
K K+ +L +D F+ + +LG G+ G VFK HK SG V+A K + +E +
Sbjct: 8 KSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE---SDL 64
Query: 109 NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILG 167
+II+E+ ++ +C+SPY+V +YG+++ + ++ I ME+ GS+ +++ + + E +
Sbjct: 65 QEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIA 124
Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVG 225
+ + +KGL YL KI HRD+K NIL+N+ G KL DFGV+GQL D+MA N+ +G
Sbjct: 125 TILKSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIG 183
Query: 226 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 285
T +M+PE +Q Y+ +DIWS+G++ +EMA G+ PP A
Sbjct: 184 TPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK----PPYA----------------- 222
Query: 286 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN 345
D P AIF + N PP ++S +F DFV KCL+KN
Sbjct: 223 -----------------DIHPMRAIFMI---PTNPPPTFRKPELWSDDFTDFVKKCLVKN 262
Query: 346 PAERADLKQLMVHAFIKRS 364
P +RA QL+ H FIK +
Sbjct: 263 PEQRATATQLLQHPFIKNA 281
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 171 bits (432), Expect = 1e-42
Identities = 103/329 (31%), Positives = 179/329 (54%), Gaps = 50/329 (15%)
Query: 37 LEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMAR 96
+E ++L R++L+ + + + ++ F+ + +LG G+ G V+K HK +G ++A
Sbjct: 1 METVQLRNPPRRQLKKL--DEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAI 58
Query: 97 KLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK 156
K + +E + +II+E+ ++ +C+SP++V +YG+++ + ++ I ME+ GS+ +++
Sbjct: 59 KQVPVE---SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR 115
Query: 157 KAGR-IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL 215
+ + E + + + +KGL YL KI HRD+K NIL+N+ G KL DFGV+GQL
Sbjct: 116 LRNKTLTEDEIATILQSTLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQL 174
Query: 216 IDSMA--NSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL 273
D+MA N+ +GT +M+PE +Q Y+ +DIWS+G++ +EMA G+ PP A
Sbjct: 175 TDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGK----PPYA----- 225
Query: 274 MFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE 333
D P AIF + N PP ++S
Sbjct: 226 -----------------------------DIHPMRAIFMI---PTNPPPTFRKPELWSDN 253
Query: 334 FQDFVNKCLIKNPAERADLKQLMVHAFIK 362
F DFV +CL+K+P +RA QL+ H F++
Sbjct: 254 FTDFVKQCLVKSPEQRATATQLLQHPFVR 282
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 161 bits (408), Expect = 8e-40
Identities = 88/211 (41%), Positives = 133/211 (63%), Gaps = 11/211 (5%)
Query: 53 FLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQII 112
F+T E++ DD I ELG G GVV KV H SG +MA KLI + + +++
Sbjct: 54 FITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLL 113
Query: 113 RELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILG 167
+L + + + Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG
Sbjct: 114 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILG 172
Query: 168 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGT 226
++++++++ L +L K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A G
Sbjct: 173 EIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGC 232
Query: 227 RSYMSPER----LQGTHYSVQSDIWSMGLSL 253
+ YM+PER L Y+V+SD+WS+G+++
Sbjct: 233 KPYMAPERINPELNQKGYNVKSDVWSLGITM 263
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 155 bits (393), Expect = 5e-38
Identities = 103/316 (32%), Positives = 163/316 (51%), Gaps = 49/316 (15%)
Query: 50 LEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN 109
L F Q +V ++ F K+ +G G+ G V+K + V+A K+I LE
Sbjct: 4 LRGFANQHSRVDP--EELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE 61
Query: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169
I +E+ VL +C+SPYI ++G++ ++ I ME++ GGS +L K G + E + +
Sbjct: 62 DIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATI 120
Query: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTR 227
++KGL YL + KI HRD+K +N+L++ +G++KL DFGV+GQL D+ N+FVGT
Sbjct: 121 LREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 179
Query: 228 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 287
+M+PE ++ + Y ++DIWS+G++ +E+A G PP++
Sbjct: 180 FWMAPEVIKQSAYDFKADIWSLGITAIELAKGE----PPNS------------------- 216
Query: 288 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPA 347
D P +F I PP L G S F++FV CL K+P
Sbjct: 217 ---------------DLHPMRVLF----LIPKNSPPTL-EGQHSKPFKEFVEACLNKDPR 256
Query: 348 ERADLKQLMVHAFIKR 363
R K+L+ H FI R
Sbjct: 257 FRPTAKELLKHKFITR 272
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 154 bits (390), Expect = 1e-37
Identities = 100/299 (33%), Positives = 157/299 (52%), Gaps = 47/299 (15%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127
F K+ ++G G+ G VFK + V+A K+I LE I +E+ VL +C+SPY+
Sbjct: 24 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 83
Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187
+YG++ D ++ I ME++ GGS +L + G + E + + ++KGL YL + KI
Sbjct: 84 KYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKI- 141
Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSD 245
HRD+K +N+L++ GE+KL DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++D
Sbjct: 142 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 201
Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305
IWS+G++ +E+A G P EL M
Sbjct: 202 IWSLGITAIELARGE-----PPHSELHPM------------------------------- 225
Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364
++L I PP L G +S ++FV CL K P+ R K+L+ H FI R+
Sbjct: 226 ------KVLFLIPKNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 277
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 154 bits (390), Expect = 1e-37
Identities = 100/299 (33%), Positives = 157/299 (52%), Gaps = 47/299 (15%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127
F K+ ++G G+ G VFK + V+A K+I LE I +E+ VL +C+SPY+
Sbjct: 36 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVT 95
Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187
+YG++ D ++ I ME++ GGS +L + G + E + + ++KGL YL + KI
Sbjct: 96 KYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKKI- 153
Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSD 245
HRD+K +N+L++ GE+KL DFGV+GQL D+ N+FVGT +M+PE ++ + Y ++D
Sbjct: 154 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 213
Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305
IWS+G++ +E+A G P EL M
Sbjct: 214 IWSLGITAIELARGE-----PPHSELHPM------------------------------- 237
Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364
++L I PP L G +S ++FV CL K P+ R K+L+ H FI R+
Sbjct: 238 ------KVLFLIPKNNPPTL-EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRN 289
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 153 bits (386), Expect = 3e-37
Identities = 98/299 (32%), Positives = 159/299 (53%), Gaps = 47/299 (15%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127
F K+ +G G+ G VFK + V+A K+I LE I +E+ VL +C+S Y+
Sbjct: 24 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83
Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIM 187
+YG++ ++ I ME++ GGS +L +AG E + + ++KGL YL + KI
Sbjct: 84 KYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLKEILKGLDYLHSEKKI- 141
Query: 188 HRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGTHYSVQSD 245
HRD+K +N+L++ +G++KL DFGV+GQL D+ N+FVGT +M+PE +Q + Y ++D
Sbjct: 142 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKAD 201
Query: 246 IWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSR 305
IWS+G++ +E+A G PP++ D
Sbjct: 202 IWSLGITAIELAKGE----PPNS----------------------------------DMH 223
Query: 306 PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 364
P +F I PP L G F+ F++F++ CL K+P+ R K+L+ H FI ++
Sbjct: 224 PMRVLF----LIPKNNPPTL-VGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKN 277
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 144 bits (363), Expect = 1e-34
Identities = 96/302 (31%), Positives = 159/302 (52%), Gaps = 51/302 (16%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIV 127
+E + ELG G G V+K +K +G + A K+I + + + + I+ E+++L C+ PYIV
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPYIV 94
Query: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-IPEQILGKVSIAVIKGLTYLREKHKI 186
GA+Y DG++ I +E GG++D ++ + R + E + V +++ L +L K +I
Sbjct: 95 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSK-RI 153
Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM--ANSFVGTRSYMSP-----ERLQGTH 239
+HRD+K N+L+ G+I+L DFGVS + + ++ +SF+GT +M+P E ++ T
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299
Y ++DIWS+G++L+EMA I PP EL
Sbjct: 214 YDYKADIWSLGITLIEMA----QIEPPH-HELN--------------------------- 241
Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359
PM + LL ++PP L +S+EF+DF+ L KNP R QL+ H
Sbjct: 242 -------PMRV--LLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHP 292
Query: 360 FI 361
F+
Sbjct: 293 FV 294
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 132 bits (332), Expect = 5e-31
Identities = 98/305 (32%), Positives = 152/305 (49%), Gaps = 54/305 (17%)
Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIR-ELQVLHECNSP 124
+DFE I +G+G G V+K + +G + A K+I LE P +++ E+ ++ +C P
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE--PGEDFAVVQQEIIMMKDCKHP 71
Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKH 184
IV ++G++ ++ ICME GGSL + G + E + VS ++GL YL K
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131
Query: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSP-----ERLQG 237
K MHRD+K +NIL+ G +KL DFGVS Q+ ++A SF+GT +M+P ER G
Sbjct: 132 K-MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGG 190
Query: 238 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 297
Y+ D+W++G++ +E+A + PP MF
Sbjct: 191 --YNQLCDLWAVGITAIELA----ELQPP-------MF---------------------- 215
Query: 298 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLM 356
D P A+F + N PPKL + +S F FV L KNP +R ++L+
Sbjct: 216 -----DLHPMRALFLMTK--SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLL 268
Query: 357 VHAFI 361
H F+
Sbjct: 269 QHPFV 273
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 131 bits (329), Expect = 1e-30
Identities = 64/138 (46%), Positives = 97/138 (70%), Gaps = 10/138 (7%)
Query: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILGKVSIAVIKGLTYL 180
Y V FYGA + +G++ ICME MD SLD+ VL K IPE ILG++++++++ L +L
Sbjct: 14 YTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 72
Query: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----L 235
K ++HRDVKPSN+L+N G +K+CDFG+SG L+DS+A + G + YM+PER L
Sbjct: 73 HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 132
Query: 236 QGTHYSVQSDIWSMGLSL 253
Y+V+SD+WS+G+++
Sbjct: 133 NQKGYNVKSDVWSLGITM 150
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 129 bits (324), Expect = 5e-30
Identities = 90/311 (28%), Positives = 152/311 (48%), Gaps = 61/311 (19%)
Query: 68 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE-CNSPYI 126
FE + +G G G V+K H +G + A K+ +++ +I +E+ +L + + I
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNI 82
Query: 127 VGFYGAFYS------DGEISICMEHMDGGSLDQVLK--KAGRIPEQILGKVSIAVIKGLT 178
+YGAF D ++ + ME GS+ ++K K + E+ + + +++GL+
Sbjct: 83 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLS 142
Query: 179 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL- 235
+L + HK++HRD+K N+L+ E+KL DFGVS QL ++ N+F+GT +M+PE +
Sbjct: 143 HLHQ-HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 236 ----QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 291
Y +SD+WS+G++ +EMA G P+
Sbjct: 202 CDENPDATYDFKSDLWSLGITAIEMAEGAPPL---------------------------- 233
Query: 292 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 351
D P A+F I P P+L S +S +FQ F+ CL+KN ++R
Sbjct: 234 ----------CDMHPMRALF----LIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA 279
Query: 352 LKQLMVHAFIK 362
+QLM H FI+
Sbjct: 280 TEQLMKHPFIR 290
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 128 bits (321), Expect = 1e-29
Identities = 87/304 (28%), Positives = 149/304 (49%), Gaps = 48/304 (15%)
Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125
D ++ + LG G G VFK K SG ++A K++ +E + + + +E+ +L C
Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 73
Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185
IV ++G++ ++ ICME GSL + + G + E + V V++GL YL + K
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPE----RLQGTH 239
I HRD+K +NIL+N GE++L DFG+S Q+ ++A SF+GT +M+PE L+G
Sbjct: 134 I-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG-G 191
Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299
Y+ DIWS+G++ +E+A + PP +F
Sbjct: 192 YNELCDIWSLGITAIELA----ELQPP-------LFDVH--------------------- 219
Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359
P+ + L+ +PP G +S F +F+ L K+P +R +++ H
Sbjct: 220 -------PLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQ 272
Query: 360 FIKR 363
+ +
Sbjct: 273 LVSQ 276
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 128 bits (321), Expect = 1e-29
Identities = 87/304 (28%), Positives = 149/304 (49%), Gaps = 48/304 (15%)
Query: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 125
D ++ + LG G G VFK K SG ++A K++ +E + + + +E+ +L C
Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV-STLQKEILILKTCRHAN 73
Query: 126 IVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHK 185
IV ++G++ ++ ICME GSL + + G + E + V V++GL YL + K
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 186 IMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPE----RLQGTH 239
I HRD+K +NIL+N GE++L DFG+S Q+ ++A SF+GT +M+PE L+G
Sbjct: 134 I-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG-G 191
Query: 240 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 299
Y+ DIWS+G++ +E+A + PP +F
Sbjct: 192 YNELCDIWSLGITAIELA----ELQPP-------LFDVH--------------------- 219
Query: 300 YGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 359
P+ + L+ +PP G +S F +F+ L K+P +R +++ H
Sbjct: 220 -------PLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQ 272
Query: 360 FIKR 363
+ +
Sbjct: 273 LVSQ 276
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 126 bits (317), Expect = 3e-29
Identities = 93/301 (30%), Positives = 149/301 (49%), Gaps = 48/301 (15%)
Query: 67 DFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 126
D+E + +G+G G V+K + +G + A K+I LE + I +E+ ++ EC I
Sbjct: 19 DYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF-SLIQQEIFMVKECKHCNI 77
Query: 127 VGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKI 186
V ++G++ S ++ ICME+ GGSL + G + E + V ++GL YL K K
Sbjct: 78 VAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK- 136
Query: 187 MHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA--NSFVGTRSYMSPERL---QGTHYS 241
MHRD+K +NIL+ G++KL DFGV+ ++ ++A SF+GT +M+PE + Y+
Sbjct: 137 MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYN 196
Query: 242 VQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYG 301
DIW++G++ +E+ + PP MF
Sbjct: 197 QLCDIWAVGITAIELG----ELQPP-------MF-------------------------- 219
Query: 302 MDSRPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVHAF 360
D P A+F L N PPKL +S F +FV L KNP +R ++L+ H F
Sbjct: 220 -DLHPMRALF--LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
Query: 361 I 361
+
Sbjct: 277 V 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,153,379
Number of Sequences: 37866
Number of extensions: 870429
Number of successful extensions: 5498
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 644
Number of HSP's successfully gapped in prelim test: 157
Number of HSP's that attempted gapping in prelim test: 3274
Number of HSP's gapped (non-prelim): 1083
length of query: 393
length of database: 18,247,518
effective HSP length: 104
effective length of query: 289
effective length of database: 14,309,454
effective search space: 4135432206
effective search space used: 4135432206
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.