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Search of human proteins with 55749678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749678 ninein-like [Homo sapiens]
(1382 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749678 ninein-like [Homo sapiens] 2718 0.0
gi|33946321 ninein isoform 5 [Homo sapiens] 455 e-127
gi|148536871 ninein isoform 1 [Homo sapiens] 455 e-127
gi|148536869 ninein isoform 2 [Homo sapiens] 455 e-127
gi|33946313 ninein isoform 4 [Homo sapiens] 424 e-118
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 122 2e-27
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 122 2e-27
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 122 2e-27
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 122 2e-27
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 122 2e-27
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 122 2e-27
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 122 2e-27
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 122 2e-27
gi|21735548 centrosomal protein 2 [Homo sapiens] 110 9e-24
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 107 8e-23
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 107 8e-23
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 107 8e-23
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 104 5e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 103 1e-21
gi|148746195 trichohyalin [Homo sapiens] 102 2e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 100 1e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 96 2e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 96 2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 96 2e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 96 2e-19
gi|16262452 cingulin [Homo sapiens] 90 2e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 87 1e-16
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 86 3e-16
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 80 1e-14
gi|81295809 pericentrin [Homo sapiens] 79 4e-14
>gi|55749678 ninein-like [Homo sapiens]
Length = 1382
Score = 2718 bits (7046), Expect = 0.0
Identities = 1382/1382 (100%), Positives = 1382/1382 (100%)
Query: 1 MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFAR 60
MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFAR
Sbjct: 1 MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFAR 60
Query: 61 VNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDA 120
VNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDA
Sbjct: 61 VNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDA 120
Query: 121 ATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDS 180
ATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDS
Sbjct: 121 ATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDS 180
Query: 181 EDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELED 240
EDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELED
Sbjct: 181 EDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELED 240
Query: 241 LFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTS 300
LFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTS
Sbjct: 241 LFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTS 300
Query: 301 SLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELT 360
SLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELT
Sbjct: 301 SLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELT 360
Query: 361 WALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE 420
WALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE
Sbjct: 361 WALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE 420
Query: 421 MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ 480
MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ
Sbjct: 421 MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ 480
Query: 481 AEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAEL 540
AEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAEL
Sbjct: 481 AEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAEL 540
Query: 541 LAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGL 600
LAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGL
Sbjct: 541 LAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGL 600
Query: 601 GPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKD 660
GPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKD
Sbjct: 601 GPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKD 660
Query: 661 MEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALC 720
MEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALC
Sbjct: 661 MEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALC 720
Query: 721 GLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLE 780
GLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLE
Sbjct: 721 GLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLE 780
Query: 781 LERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQ 840
LERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQ
Sbjct: 781 LERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQ 840
Query: 841 EGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASH 900
EGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASH
Sbjct: 841 EGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASH 900
Query: 901 GPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEP 960
GPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEP
Sbjct: 901 GPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEP 960
Query: 961 PLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRG 1020
PLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRG
Sbjct: 961 PLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRG 1020
Query: 1021 SLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRE 1080
SLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRE
Sbjct: 1021 SLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRE 1080
Query: 1081 NDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNR 1140
NDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNR
Sbjct: 1081 NDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNR 1140
Query: 1141 QNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK 1200
QNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK
Sbjct: 1141 QNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK 1200
Query: 1201 LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVA 1260
LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVA
Sbjct: 1201 LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVA 1260
Query: 1261 ELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF 1320
ELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF
Sbjct: 1261 ELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF 1320
Query: 1321 EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAAL 1380
EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAAL
Sbjct: 1321 EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAAL 1380
Query: 1381 SV 1382
SV
Sbjct: 1381 SV 1382
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 455 bits (1170), Expect = e-127
Identities = 306/828 (36%), Positives = 470/828 (56%), Gaps = 55/828 (6%)
Query: 1 MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA 59
MDE E++ + ++L+E++ S DTTGTG L ++ELT LC L LE+ PVL QTLL ++
Sbjct: 1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
Query: 60 RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD 119
RV+F++FKE + +LS R + E S PKYV G K YGRRS PE +
Sbjct: 61 RVHFDQFKEALILILS-----RTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQE 115
Query: 120 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT 177
+ E V E + + SH+ + + +E K ++E +EA+GQL+
Sbjct: 116 SVEEFPEVTVIEPLDEEARPSHI------------PAGDCSEHWKTQRSEEYEAEGQLRF 163
Query: 178 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE 237
W+ +D + Q SP D E +++ V E+LG+ GHL+ ++L +C+ GLQ ++ E
Sbjct: 164 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM 223
Query: 238 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT 297
LE++F+ LD DG +S+E+F GLF + +L +ST + K Q +ESG TT
Sbjct: 224 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT 281
Query: 298 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLL 357
T+S++ S R+FS +DDG G A +++L W +EGI+N +EIL++LDFS+D +NL
Sbjct: 282 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT 340
Query: 358 ELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEF 417
ELT AL+NEL+ +++ QAALA + E+ + +V+Q+ RE++K R DL++AEK
Sbjct: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
Query: 418 VKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E+DD H+ +E+ E ++ L++ Y+ER++ L++E+ ERE +QA +QR LE ++
Sbjct: 401 ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 460
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK---LE 534
+ + EE +R++L L+LKENSRL+ E++E EKL++ E L KLQ++LE VL +K L+
Sbjct: 461 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
Query: 535 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRHSPSWS 589
P SAE QEER + EYE +CR LQD+ DELQ+ELE G RLP ++SPS
Sbjct: 521 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KNSPSEE 579
Query: 590 PDGRRRQLP---GLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLETKVNY 642
+ + GLG S N +SIE EL++EQ+KE H++D LR +LE KV +
Sbjct: 580 VEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH 635
Query: 643 YEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHEKSQEVIWGLQEQLQDTA 701
YE+++ + +K +++M+Q E LE Q +DL+ E+ E + + + T
Sbjct: 636 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695
Query: 702 RGPEPE---QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGAL----PAR 754
R E + Q+ L T L L+H L+ +A+A E GL +
Sbjct: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
Query: 755 RDLTLELEEPPQGPL----PRGSQRSEQLELERALKLQPCASEKRAQM 798
R LT ELE+ Q L + + E+L E K Q E R +M
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM 803
Score = 67.8 bits (164), Expect = 7e-11
Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)
Query: 408 ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457
ER + E+ ++ +++L + ++ QG RL L S EVEA E
Sbjct: 531 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
Query: 458 RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514
L E+ + ++E ++ Q +E R+ L L+ ++ +K++ E V +
Sbjct: 591 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 515 ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566
+ + ++ L+ ++ E+ A+ + AAVLKE +E CR +++
Sbjct: 651 QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
Query: 567 ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604
EL+A L A + R S +W+ + G ++L
Sbjct: 710 EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 769
Query: 605 ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649
++ L + E EL E +++H ++L R ++ET+ N +I A
Sbjct: 770 LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 828
Query: 650 -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702
L+ + +E KD+++ +R E S E +K +L + ++QE++ ++ + T+
Sbjct: 829 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 888
Query: 703 GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759
E+ L + L + + LQ + R +E + S L L +
Sbjct: 889 VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 946
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819
EL E + G+ SEQL +R +L+ ++R +M +S L E + A + D
Sbjct: 947 ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1003
Query: 820 PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876
E + + Q+ T L L+ GC GE + GDG S G
Sbjct: 1004 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1058
Query: 877 PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936
+ Q + + SR+Q ++ EP ++ L++P
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1111
Query: 937 GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996
A QT+P + + + + L ++++ R
Sbjct: 1112 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1165
Query: 997 QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
Q+ + +E ++E + E R S Q++ Q A + K
Sbjct: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1220
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
K D+ + L+ ++ LE+ + +L + +S EN L ++EL E+
Sbjct: 1221 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1272
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
+D E L+ +KE EV Q++ K + ++ L L + + +NEE
Sbjct: 1273 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1321
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233
V + L +E++ S Q+ D LE L E L +L QTLEE +V
Sbjct: 1322 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1377
Query: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287
+ H + + + + + Q + V +A LH + E+ R + EE+
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
Query: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332
L ++ + I L+ + LQE KLKE+ EK + ++ +
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
L + + + + ++ + ++++ +L ++ LN+
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
Score = 62.8 bits (151), Expect = 2e-09
Identities = 83/356 (23%), Positives = 152/356 (42%), Gaps = 68/356 (19%)
Query: 1014 VEVARRGSLPSH--LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA 1071
V+ + SL H + Q SW+ Q A+ L+ + + K+ +LED V+
Sbjct: 1727 VDKLAKSSLLEHRIATMKQEQKSWEHQSAS---------LKSQLVASQEKVQNLEDTVQN 1777
Query: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE--------STHDA----QRK 1119
+ + ++D +E LK ++ + ++L+ A +TH + Q+K
Sbjct: 1778 VNLQMSRMKSD---LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
Query: 1120 EIE------VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA-STHQAQ--- 1169
+ ++ ++++ E E L QN K +L+ +V QL HQ
Sbjct: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1894
Query: 1170 ------NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
E+ +++++ ++ ++ Q+ L ELE ++ E++ L+ +L
Sbjct: 1895 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1954
Query: 1224 QTLEESQDQVQGA---------HLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274
+ L E Q A L+L Q QA +VP+++ +L R L LQ E+
Sbjct: 1955 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQA-----CPMVPREQFLQLQRQL-LQAERIN 2008
Query: 1275 RRLDAQREEH-----------EKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQ 1319
+ L + E E+ + EER+ E E LK ++ LLQEKV++LKEQ
Sbjct: 2009 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2064
Score = 54.7 bits (130), Expect = 6e-07
Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)
Query: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103
REK+ + + L E + + VD + + +L EE LKN+L +
Sbjct: 381 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 440
Query: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158
R++ L+ A +EIE K ++ + + ++N +++L + ++ +
Sbjct: 441 REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 500
Query: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
L ++ + E + + LTQ E R + DQ+ +L+ ELE
Sbjct: 501 TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
Query: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249
+ + L+LP + ++ +E + ++ H L + Q + QH +
Sbjct: 561 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
Query: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306
++ RL +D+V + L ++ + ++ HE + E+++ + LKN
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 676
Query: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345
LQ + LKE + T K L +K L E HL L Q
Sbjct: 677 AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 735
Query: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370
A+ E++R + S EEKVR L +
Sbjct: 736 ASFEREREGLQSSAWTEEKVRGLTQ 760
Score = 52.4 bits (124), Expect = 3e-06
Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)
Query: 966 ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022
A+CR + E+ Q ++EE+ + + E +AR A + S E R G
Sbjct: 693 ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 746
Query: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075
S +G QE QL + E T E K+ +E L++ +E
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
Query: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129
+ R + + + +++E + L++ GR RQEL+ + ++ + E K +
Sbjct: 807 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
Query: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185
+ C+E + L K+ L + L L QE + +EH V Q L Q LE
Sbjct: 867 QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 920
Query: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241
++ + Q SDQI +L+ S + E + L ++ Q A RL
Sbjct: 921 DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 970
Query: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299
+ + +H Q+R + +LL+++ + D +R E ++ + +++E +
Sbjct: 971 RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
Query: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357
+ ML +E+ E + LL ++L EN ++ +LQ E+ A K+
Sbjct: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1080
Query: 1358 SRLLEEKVRALNKLVSRIAP 1377
+ + ++ L + + ++ P
Sbjct: 1081 NVKMATEISRLQQRLQKLEP 1100
Score = 48.9 bits (115), Expect = 3e-05
Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)
Query: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079
L D Q +A E +TK+ L R+ + T L+ +DV+ EK +L+
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
Query: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102
E R E +L +EN++L+N++
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557
Query: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159
V+QE A + + +K+I LK ++ E L+++N +++L +LN R+ ++
Sbjct: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617
Query: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200
QE + + E +V L SLE + + Q+ +Q+
Sbjct: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677
Query: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258
L+ ELE + Q H+ L S+ Q + S L+ ++A ++ L V + +
Sbjct: 1678 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
Query: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317
+ E HR+ +++ EQ + + Q + QL A++E+V+ E ++N+ + + L+
Sbjct: 1735 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1791
Query: 1318 -EQFEKNTKSDLLLKELYVENA 1338
+Q ++ K +++ ++NA
Sbjct: 1792 TQQEKEALKQEVMSLHKQLQNA 1813
Score = 38.1 bits (87), Expect = 0.059
Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)
Query: 333 QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387
Q +Q GRE +++ + + + +E + D + +T +SA+Q Y QEL
Sbjct: 793 QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 848
Query: 388 -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446
Q+ + Q E+D+ Q+ A+ E +KE T + ++ + LE+ Y+E
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 447 LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506
L + + ER+ + R E +++ L +++ + R +E E
Sbjct: 905 L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 953
Query: 507 VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566
V+ + SE+LA + + LE + + ++LLA E A + + + ++
Sbjct: 954 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
Query: 567 ELQAELE 573
LQ++++
Sbjct: 1014 RLQSKIK 1020
Score = 37.0 bits (84), Expect = 0.13
Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
QE + Q VE L ++ + + ++ + N E ++ L++L ++ + L Q
Sbjct: 1563 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
Query: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503
+E + E E E+ E+ R + V L+AE + ++ + + +EN L+ E
Sbjct: 1623 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1682
Query: 504 IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563
+ EK+ R DL + + + +L+ E+ +LKE E +L
Sbjct: 1683 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1725
Query: 564 RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621
D+L LE A + + + S + QL A + N L
Sbjct: 1726 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1781
Query: 622 MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677
M ++K DLR + K ++E+ +L + + K S L Q+
Sbjct: 1782 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
Query: 678 --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730
L+ L + Q+++W E+LQ + + E Q L +H HL
Sbjct: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
Score = 35.8 bits (81), Expect = 0.29
Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
S HQA + I+ L + +++VVR + +KLR +L+ +E
Sbjct: 356 SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 396
Query: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283
++L S +V H + + +L+++ ++R+A L L + EQ ++ QR E
Sbjct: 397 KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
Query: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330
E++++ TEE + L +E L E +KL E + ++N ++ L
Sbjct: 455 LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 514
Query: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
K +L +A + + + E+Q R+L+++V L
Sbjct: 515 KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 554
Score = 35.8 bits (81), Expect = 0.29
Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091
Q EQLA+ ++ ++E+ +M +KLL +E++ +A + D
Sbjct: 957 QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1002
Query: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151
R R E+ S ++ KE++ S +V+ + LS
Sbjct: 1003 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1051
Query: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211
+LQ G++ EE+ + L ++ E+ V+ + + +I +L+ L+ L
Sbjct: 1052 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1099
Query: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271
P ++ L+E + G + LQ+ R + V H L L+ +
Sbjct: 1100 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
Query: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331
+ R ++Q E ++EE+E ++ L+ + E +E + L +
Sbjct: 1151 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1205
Query: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371
+L + A RA EK++ +L++K++ L ++
Sbjct: 1206 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1241
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 455 bits (1170), Expect = e-127
Identities = 306/828 (36%), Positives = 470/828 (56%), Gaps = 55/828 (6%)
Query: 1 MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA 59
MDE E++ + ++L+E++ S DTTGTG L ++ELT LC L LE+ PVL QTLL ++
Sbjct: 1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
Query: 60 RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD 119
RV+F++FKE + +LS R + E S PKYV G K YGRRS PE +
Sbjct: 61 RVHFDQFKEALILILS-----RTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQE 115
Query: 120 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT 177
+ E V E + + SH+ + + +E K ++E +EA+GQL+
Sbjct: 116 SVEEFPEVTVIEPLDEEARPSHI------------PAGDCSEHWKTQRSEEYEAEGQLRF 163
Query: 178 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE 237
W+ +D + Q SP D E +++ V E+LG+ GHL+ ++L +C+ GLQ ++ E
Sbjct: 164 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM 223
Query: 238 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT 297
LE++F+ LD DG +S+E+F GLF + +L +ST + K Q +ESG TT
Sbjct: 224 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT 281
Query: 298 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLL 357
T+S++ S R+FS +DDG G A +++L W +EGI+N +EIL++LDFS+D +NL
Sbjct: 282 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT 340
Query: 358 ELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEF 417
ELT AL+NEL+ +++ QAALA + E+ + +V+Q+ RE++K R DL++AEK
Sbjct: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
Query: 418 VKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E+DD H+ +E+ E ++ L++ Y+ER++ L++E+ ERE +QA +QR LE ++
Sbjct: 401 ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 460
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK---LE 534
+ + EE +R++L L+LKENSRL+ E++E EKL++ E L KLQ++LE VL +K L+
Sbjct: 461 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
Query: 535 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRHSPSWS 589
P SAE QEER + EYE +CR LQD+ DELQ+ELE G RLP ++SPS
Sbjct: 521 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KNSPSEE 579
Query: 590 PDGRRRQLP---GLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLETKVNY 642
+ + GLG S N +SIE EL++EQ+KE H++D LR +LE KV +
Sbjct: 580 VEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH 635
Query: 643 YEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHEKSQEVIWGLQEQLQDTA 701
YE+++ + +K +++M+Q E LE Q +DL+ E+ E + + + T
Sbjct: 636 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695
Query: 702 RGPEPE---QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGAL----PAR 754
R E + Q+ L T L L+H L+ +A+A E GL +
Sbjct: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
Query: 755 RDLTLELEEPPQGPL----PRGSQRSEQLELERALKLQPCASEKRAQM 798
R LT ELE+ Q L + + E+L E K Q E R +M
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM 803
Score = 67.8 bits (164), Expect = 7e-11
Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)
Query: 408 ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457
ER + E+ ++ +++L + ++ QG RL L S EVEA E
Sbjct: 531 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
Query: 458 RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514
L E+ + ++E ++ Q +E R+ L L+ ++ +K++ E V +
Sbjct: 591 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 515 ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566
+ + ++ L+ ++ E+ A+ + AAVLKE +E CR +++
Sbjct: 651 QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
Query: 567 ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604
EL+A L A + R S +W+ + G ++L
Sbjct: 710 EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 769
Query: 605 ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649
++ L + E EL E +++H ++L R ++ET+ N +I A
Sbjct: 770 LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 828
Query: 650 -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702
L+ + +E KD+++ +R E S E +K +L + ++QE++ ++ + T+
Sbjct: 829 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 888
Query: 703 GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759
E+ L + L + + LQ + R +E + S L L +
Sbjct: 889 VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 946
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819
EL E + G+ SEQL +R +L+ ++R +M +S L E + A + D
Sbjct: 947 ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1003
Query: 820 PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876
E + + Q+ T L L+ GC GE + GDG S G
Sbjct: 1004 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1058
Query: 877 PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936
+ Q + + SR+Q ++ EP ++ L++P
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1111
Query: 937 GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996
A QT+P + + + + L ++++ R
Sbjct: 1112 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1165
Query: 997 QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
Q+ + +E ++E + E R S Q++ Q A + K
Sbjct: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1220
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
K D+ + L+ ++ LE+ + +L + +S EN L ++EL E+
Sbjct: 1221 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1272
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
+D E L+ +KE EV Q++ K + ++ L L + + +NEE
Sbjct: 1273 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1321
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233
V + L +E++ S Q+ D LE L E L +L QTLEE +V
Sbjct: 1322 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1377
Query: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287
+ H + + + + + Q + V +A LH + E+ R + EE+
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
Query: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332
L ++ + I L+ + LQE KLKE+ EK + ++ +
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
L + + + + ++ + ++++ +L ++ LN+
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
Score = 54.7 bits (130), Expect = 6e-07
Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)
Query: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103
REK+ + + L E + + VD + + +L EE LKN+L +
Sbjct: 381 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 440
Query: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158
R++ L+ A +EIE K ++ + + ++N +++L + ++ +
Sbjct: 441 REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 500
Query: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
L ++ + E + + LTQ E R + DQ+ +L+ ELE
Sbjct: 501 TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
Query: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249
+ + L+LP + ++ +E + ++ H L + Q + QH +
Sbjct: 561 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
Query: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306
++ RL +D+V + L ++ + ++ HE + E+++ + LKN
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 676
Query: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345
LQ + LKE + T K L +K L E HL L Q
Sbjct: 677 AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 735
Query: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370
A+ E++R + S EEKVR L +
Sbjct: 736 ASFEREREGLQSSAWTEEKVRGLTQ 760
Score = 52.4 bits (124), Expect = 3e-06
Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)
Query: 966 ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022
A+CR + E+ Q ++EE+ + + E +AR A + S E R G
Sbjct: 693 ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 746
Query: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075
S +G QE QL + E T E K+ +E L++ +E
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
Query: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129
+ R + + + +++E + L++ GR RQEL+ + ++ + E K +
Sbjct: 807 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
Query: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185
+ C+E + L K+ L + L L QE + +EH V Q L Q LE
Sbjct: 867 QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 920
Query: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241
++ + Q SDQI +L+ S + E + L ++ Q A RL
Sbjct: 921 DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 970
Query: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299
+ + +H Q+R + +LL+++ + D +R E ++ + +++E +
Sbjct: 971 RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
Query: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357
+ ML +E+ E + LL ++L EN ++ +LQ E+ A K+
Sbjct: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1080
Query: 1358 SRLLEEKVRALNKLVSRIAP 1377
+ + ++ L + + ++ P
Sbjct: 1081 NVKMATEISRLQQRLQKLEP 1100
Score = 48.9 bits (115), Expect = 3e-05
Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)
Query: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079
L D Q +A E +TK+ L R+ + T L+ +DV+ EK +L+
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
Query: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102
E R E +L +EN++L+N++
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557
Query: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159
V+QE A + + +K+I LK ++ E L+++N +++L +LN R+ ++
Sbjct: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617
Query: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200
QE + + E +V L SLE + + Q+ +Q+
Sbjct: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677
Query: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258
L+ ELE + Q H+ L S+ Q + S L+ ++A ++ L V + +
Sbjct: 1678 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
Query: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317
+ E HR+ +++ EQ + + Q + QL A++E+V+ E ++N+ + + L+
Sbjct: 1735 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1791
Query: 1318 -EQFEKNTKSDLLLKELYVENA 1338
+Q ++ K +++ ++NA
Sbjct: 1792 TQQEKEALKQEVMSLHKQLQNA 1813
Score = 38.1 bits (87), Expect = 0.059
Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)
Query: 333 QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387
Q +Q GRE +++ + + + +E + D + +T +SA+Q Y QEL
Sbjct: 793 QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 848
Query: 388 -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446
Q+ + Q E+D+ Q+ A+ E +KE T + ++ + LE+ Y+E
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 447 LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506
L + + ER+ + R E +++ L +++ + R +E E
Sbjct: 905 L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 953
Query: 507 VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566
V+ + SE+LA + + LE + + ++LLA E A + + + ++
Sbjct: 954 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
Query: 567 ELQAELE 573
LQ++++
Sbjct: 1014 RLQSKIK 1020
Score = 37.0 bits (84), Expect = 0.13
Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
QE + Q VE L ++ + + ++ + N E ++ L++L ++ + L Q
Sbjct: 1563 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
Query: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503
+E + E E E+ E+ R + V L+AE + ++ + + +EN L+ E
Sbjct: 1623 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1682
Query: 504 IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563
+ EK+ R DL + + + +L+ E+ +LKE E +L
Sbjct: 1683 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1725
Query: 564 RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621
D+L LE A + + + S + QL A + N L
Sbjct: 1726 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1781
Query: 622 MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677
M ++K DLR + K ++E+ +L + + K S L Q+
Sbjct: 1782 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
Query: 678 --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730
L+ L + Q+++W E+LQ + + E Q L +H HL
Sbjct: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
Score = 35.8 bits (81), Expect = 0.29
Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
S HQA + I+ L + +++VVR + +KLR +L+ +E
Sbjct: 356 SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 396
Query: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283
++L S +V H + + +L+++ ++R+A L L + EQ ++ QR E
Sbjct: 397 KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
Query: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330
E++++ TEE + L +E L E +KL E + ++N ++ L
Sbjct: 455 LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 514
Query: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
K +L +A + + + E+Q R+L+++V L
Sbjct: 515 KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 554
Score = 35.8 bits (81), Expect = 0.29
Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091
Q EQLA+ ++ ++E+ +M +KLL +E++ +A + D
Sbjct: 957 QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1002
Query: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151
R R E+ S ++ KE++ S +V+ + LS
Sbjct: 1003 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1051
Query: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211
+LQ G++ EE+ + L ++ E+ V+ + + +I +L+ L+ L
Sbjct: 1052 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1099
Query: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271
P ++ L+E + G + LQ+ R + V H L L+ +
Sbjct: 1100 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
Query: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331
+ R ++Q E ++EE+E ++ L+ + E +E + L +
Sbjct: 1151 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1205
Query: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371
+L + A RA EK++ +L++K++ L ++
Sbjct: 1206 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1241
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 455 bits (1170), Expect = e-127
Identities = 306/828 (36%), Positives = 470/828 (56%), Gaps = 55/828 (6%)
Query: 1 MDE-EENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFA 59
MDE E++ + ++L+E++ S DTTGTG L ++ELT LC L LE+ PVL QTLL ++
Sbjct: 1 MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEEVAPVLQQTLLQDNLLG 60
Query: 60 RVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCD 119
RV+F++FKE + +LS R + E S PKYV G K YGRRS PE +
Sbjct: 61 RVHFDQFKEALILILS-----RTLSNEEHFQEPDCSLEAQPKYVRGGKRYGRRSLPEFQE 115
Query: 120 AATEARRVP--EQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQT 177
+ E V E + + SH+ + + +E K ++E +EA+GQL+
Sbjct: 116 SVEEFPEVTVIEPLDEEARPSHI------------PAGDCSEHWKTQRSEEYEAEGQLRF 163
Query: 178 WDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEE 237
W+ +D + Q SP D E +++ V E+LG+ GHL+ ++L +C+ GLQ ++ E
Sbjct: 164 WNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGEM 223
Query: 238 LEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTT 297
LE++F+ LD DG +S+E+F GLF + +L +ST + K Q +ESG TT
Sbjct: 224 LEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDESGRRTT 281
Query: 298 TTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLL 357
T+S++ S R+FS +DDG G A +++L W +EGI+N +EIL++LDFS+D +NL
Sbjct: 282 TSSAMTSTIG-FRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLDGNINLT 340
Query: 358 ELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEF 417
ELT AL+NEL+ +++ QAALA + E+ + +V+Q+ RE++K R DL++AEK
Sbjct: 341 ELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDKAEKLKSLM 400
Query: 418 VKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E+DD H+ +E+ E ++ L++ Y+ER++ L++E+ ERE +QA +QR LE ++
Sbjct: 401 ASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIE 460
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDK---LE 534
+ + EE +R++L L+LKENSRL+ E++E EKL++ E L KLQ++LE VL +K L+
Sbjct: 461 KAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLD 520
Query: 535 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE-----GLWARLPKNRHSPSWS 589
P SAE QEER + EYE +CR LQD+ DELQ+ELE G RLP ++SPS
Sbjct: 521 PSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPL-KNSPSEE 579
Query: 590 PDGRRRQLP---GLGPAGISFLGNSAPVSIETELMMEQVKE-HYQD---LRTQLETKVNY 642
+ + GLG S N +SIE EL++EQ+KE H++D LR +LE KV +
Sbjct: 580 VEANSGGIEPEHGLG----SEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRH 635
Query: 643 YEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLE-ELHEKSQEVIWGLQEQLQDTA 701
YE+++ + +K +++M+Q E LE Q +DL+ E+ E + + + T
Sbjct: 636 YEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATC 695
Query: 702 RGPEPE---QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGAL----PAR 754
R E + Q+ L T L L+H L+ +A+A E GL +
Sbjct: 696 RHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKV 755
Query: 755 RDLTLELEEPPQGPL----PRGSQRSEQLELERALKLQPCASEKRAQM 798
R LT ELE+ Q L + + E+L E K Q E R +M
Sbjct: 756 RGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKM 803
Score = 126 bits (317), Expect = 1e-28
Identities = 114/418 (27%), Positives = 201/418 (48%), Gaps = 68/418 (16%)
Query: 1014 VEVARRGSLPSH--LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA 1071
V+ + SL H + Q SW+ Q A+ L+ + + K+ +LED V+
Sbjct: 1727 VDKLAKSSLLEHRIATMKQEQKSWEHQSAS---------LKSQLVASQEKVQNLEDTVQN 1777
Query: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE--------STHDA----QRK 1119
+ + ++D +E LK ++ + ++L+ A +TH + Q+K
Sbjct: 1778 VNLQMSRMKSD---LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1834
Query: 1120 EIE------VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA-STHQAQ--- 1169
+ ++ ++++ E E L QN K +L+ +V QL HQ
Sbjct: 1835 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1894
Query: 1170 ------NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
E+ +++++ ++ ++ Q+ L ELE ++ E++ L+ +L
Sbjct: 1895 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1954
Query: 1224 QTLEESQDQVQGA---------HLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274
+ L E Q A L+L Q QA +VP+++ +L R L LQ E+
Sbjct: 1955 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQA-----CPMVPREQFLQLQRQL-LQAERIN 2008
Query: 1275 RRLDAQREEH-----------EKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKN 1323
+ L + E E+ + EER+ E E LK ++ LLQEKV++LKEQ KN
Sbjct: 2009 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKN 2068
Query: 1324 TKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAALS 1381
TK+D ++K+LYVENA L++AL+ TE++Q+ AEK++ LLEEK+ +L+ +V + PA L+
Sbjct: 2069 TKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNLTPAPLT 2126
Score = 67.8 bits (164), Expect = 7e-11
Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)
Query: 408 ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457
ER + E+ ++ +++L + ++ QG RL L S EVEA E
Sbjct: 531 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 590
Query: 458 RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514
L E+ + ++E ++ Q +E R+ L L+ ++ +K++ E V +
Sbjct: 591 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 650
Query: 515 ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566
+ + ++ L+ ++ E+ A+ + AAVLKE +E CR +++
Sbjct: 651 QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 709
Query: 567 ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604
EL+A L A + R S +W+ + G ++L
Sbjct: 710 EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 769
Query: 605 ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649
++ L + E EL E +++H ++L R ++ET+ N +I A
Sbjct: 770 LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 828
Query: 650 -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702
L+ + +E KD+++ +R E S E +K +L + ++QE++ ++ + T+
Sbjct: 829 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 888
Query: 703 GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759
E+ L + L + + LQ + R +E + S L L +
Sbjct: 889 VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 946
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819
EL E + G+ SEQL +R +L+ ++R +M +S L E + A + D
Sbjct: 947 ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1003
Query: 820 PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876
E + + Q+ T L L+ GC GE + GDG S G
Sbjct: 1004 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1058
Query: 877 PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936
+ Q + + SR+Q ++ EP ++ L++P
Sbjct: 1059 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1111
Query: 937 GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996
A QT+P + + + + L ++++ R
Sbjct: 1112 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1165
Query: 997 QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
Q+ + +E ++E + E R S Q++ Q A + K
Sbjct: 1166 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1220
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
K D+ + L+ ++ LE+ + +L + +S EN L ++EL E+
Sbjct: 1221 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1272
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
+D E L+ +KE EV Q++ K + ++ L L + + +NEE
Sbjct: 1273 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1321
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233
V + L +E++ S Q+ D LE L E L +L QTLEE +V
Sbjct: 1322 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1377
Query: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287
+ H + + + + + Q + V +A LH + E+ R + EE+
Sbjct: 1378 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1437
Query: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332
L ++ + I L+ + LQE KLKE+ EK + ++ +
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
L + + + + ++ + ++++ +L ++ LN+
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1535
Score = 54.7 bits (130), Expect = 6e-07
Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)
Query: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103
REK+ + + L E + + VD + + +L EE LKN+L +
Sbjct: 381 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 440
Query: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158
R++ L+ A +EIE K ++ + + ++N +++L + ++ +
Sbjct: 441 REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 500
Query: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
L ++ + E + + LTQ E R + DQ+ +L+ ELE
Sbjct: 501 TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 560
Query: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249
+ + L+LP + ++ +E + ++ H L + Q + QH +
Sbjct: 561 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 620
Query: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306
++ RL +D+V + L ++ + ++ HE + E+++ + LKN
Sbjct: 621 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 676
Query: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345
LQ + LKE + T K L +K L E HL L Q
Sbjct: 677 AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 735
Query: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370
A+ E++R + S EEKVR L +
Sbjct: 736 ASFEREREGLQSSAWTEEKVRGLTQ 760
Score = 52.4 bits (124), Expect = 3e-06
Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)
Query: 966 ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022
A+CR + E+ Q ++EE+ + + E +AR A + S E R G
Sbjct: 693 ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 746
Query: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075
S +G QE QL + E T E K+ +E L++ +E
Sbjct: 747 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 806
Query: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129
+ R + + + +++E + L++ GR RQEL+ + ++ + E K +
Sbjct: 807 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 866
Query: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185
+ C+E + L K+ L + L L QE + +EH V Q L Q LE
Sbjct: 867 QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 920
Query: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241
++ + Q SDQI +L+ S + E + L ++ Q A RL
Sbjct: 921 DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 970
Query: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299
+ + +H Q+R + +LL+++ + D +R E ++ + +++E +
Sbjct: 971 RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1023
Query: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357
+ ML +E+ E + LL ++L EN ++ +LQ E+ A K+
Sbjct: 1024 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1080
Query: 1358 SRLLEEKVRALNKLVSRIAP 1377
+ + ++ L + + ++ P
Sbjct: 1081 NVKMATEISRLQQRLQKLEP 1100
Score = 48.9 bits (115), Expect = 3e-05
Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)
Query: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079
L D Q +A E +TK+ L R+ + T L+ +DV+ EK +L+
Sbjct: 1438 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1497
Query: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102
E R E +L +EN++L+N++
Sbjct: 1498 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1557
Query: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159
V+QE A + + +K+I LK ++ E L+++N +++L +LN R+ ++
Sbjct: 1558 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1617
Query: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200
QE + + E +V L SLE + + Q+ +Q+
Sbjct: 1618 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1677
Query: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258
L+ ELE + Q H+ L S+ Q + S L+ ++A ++ L V + +
Sbjct: 1678 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1734
Query: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317
+ E HR+ +++ EQ + + Q + QL A++E+V+ E ++N+ + + L+
Sbjct: 1735 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1791
Query: 1318 -EQFEKNTKSDLLLKELYVENA 1338
+Q ++ K +++ ++NA
Sbjct: 1792 TQQEKEALKQEVMSLHKQLQNA 1813
Score = 38.1 bits (87), Expect = 0.059
Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)
Query: 333 QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387
Q +Q GRE +++ + + + +E + D + +T +SA+Q Y QEL
Sbjct: 793 QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 848
Query: 388 -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446
Q+ + Q E+D+ Q+ A+ E +KE T + ++ + LE+ Y+E
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 447 LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506
L + + ER+ + R E +++ L +++ + R +E E
Sbjct: 905 L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 953
Query: 507 VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566
V+ + SE+LA + + LE + + ++LLA E A + + + ++
Sbjct: 954 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1013
Query: 567 ELQAELE 573
LQ++++
Sbjct: 1014 RLQSKIK 1020
Score = 37.0 bits (84), Expect = 0.13
Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
QE + Q VE L ++ + + ++ + N E ++ L++L ++ + L Q
Sbjct: 1563 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1622
Query: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503
+E + E E E+ E+ R + V L+AE + ++ + + +EN L+ E
Sbjct: 1623 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1682
Query: 504 IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563
+ EK+ R DL + + + +L+ E+ +LKE E +L
Sbjct: 1683 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1725
Query: 564 RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621
D+L LE A + + + S + QL A + N L
Sbjct: 1726 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1781
Query: 622 MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677
M ++K DLR + K ++E+ +L + + K S L Q+
Sbjct: 1782 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
Query: 678 --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730
L+ L + Q+++W E+LQ + + E Q L +H HL
Sbjct: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
Score = 35.8 bits (81), Expect = 0.29
Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
S HQA + I+ L + +++VVR + +KLR +L+ +E
Sbjct: 356 SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 396
Query: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283
++L S +V H + + +L+++ ++R+A L L + EQ ++ QR E
Sbjct: 397 KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 454
Query: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330
E++++ TEE + L +E L E +KL E + ++N ++ L
Sbjct: 455 LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 514
Query: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
K +L +A + + + E+Q R+L+++V L
Sbjct: 515 KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 554
Score = 35.8 bits (81), Expect = 0.29
Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091
Q EQLA+ ++ ++E+ +M +KLL +E++ +A + D
Sbjct: 957 QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1002
Query: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151
R R E+ S ++ KE++ S +V+ + LS
Sbjct: 1003 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1051
Query: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211
+LQ G++ EE+ + L ++ E+ V+ + + +I +L+ L+ L
Sbjct: 1052 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1099
Query: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271
P ++ L+E + G + LQ+ R + V H L L+ +
Sbjct: 1100 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1150
Query: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331
+ R ++Q E ++EE+E ++ L+ + E +E + L +
Sbjct: 1151 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1205
Query: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371
+L + A RA EK++ +L++K++ L ++
Sbjct: 1206 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1241
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 424 bits (1090), Expect = e-118
Identities = 289/794 (36%), Positives = 444/794 (55%), Gaps = 54/794 (6%)
Query: 34 QLCLKLHLEQQLPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESA 93
+LC L LE+ PVL QTLL ++ RV+F++FKE + +LS R + E
Sbjct: 41 ELCHMLSLEEVAPVLQQTLLQDNLLGRVHFDQFKEALILILS-----RTLSNEEHFQEPD 95
Query: 94 ASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVP--EQQTQASLKSHLWRSASLESVES 151
S PKYV G K YGRRS PE ++ E V E + + SH+
Sbjct: 96 CSLEAQPKYVRGGKRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHI----------- 144
Query: 152 PKSDEEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVG 211
+ + +E K ++E +EA+GQL+ W+ +D + Q SP D E +++ V E+LG+
Sbjct: 145 -PAGDCSEHWKTQRSEEYEAEGQLRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGIT 203
Query: 212 SSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLL 271
GHL+ ++L +C+ GLQ ++ E LE++F+ LD DG +S+E+F GLF + +L
Sbjct: 204 RDGHLNRKKLVSICEQYGLQNVDGEMLEEVFHNLDPDGT--MSVEDFFYGLFKNGKSLTP 261
Query: 272 ESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMW 331
+ST + K Q +ESG TTT+S++ S R+FS +DDG G A +++L W
Sbjct: 262 SASTPYRQLKRHLSMQSFDESGRRTTTSSAMTSTIG-FRVFSCLDDGMGHASVERILDTW 320
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
+EGI+N +EIL++LDFS+D +NL ELT AL+NEL+ +++ QAALA + E+ +
Sbjct: 321 QEEGIENSQEILKALDFSLDGNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLE 380
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
+V+Q+ RE++K R DL++AEK E+DD H+ +E+ E ++ L++ Y+ER++ L+
Sbjct: 381 RVDQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALK 440
Query: 452 SEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKL 511
+E+ ERE +QA +QR LE ++ + + EE +R++L L+LKENSRL+ E++E EKL
Sbjct: 441 NELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKL 500
Query: 512 SDSERLALKLQKDLEFVLKDK---LEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDEL 568
++ E L KLQ++LE VL +K L+P SAE QEER + EYE +CR LQD+ DEL
Sbjct: 501 AEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
Query: 569 QAELE-----GLWARLPKNRHSPSWSPDGRRRQLP---GLGPAGISFLGNSAPVSIETEL 620
Q+ELE G RLP ++SPS + + GLG S N +SIE EL
Sbjct: 561 QSELEEYRAQGRVLRLPL-KNSPSEEVEANSGGIEPEHGLG----SEECNPLNMSIEAEL 615
Query: 621 MMEQVKE-HYQD---LRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQK 676
++EQ+KE H++D LR +LE KV +YE+++ + +K +++M+Q E LE Q
Sbjct: 616 VIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQI 675
Query: 677 ADLE-ELHEKSQEVIWGLQEQLQDTARGPEPE---QMGLAPCCTQALCGLALRHHSHLQQ 732
+DL+ E+ E + + + T R E + Q+ L T L L+H L+
Sbjct: 676 SDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKA 735
Query: 733 IRREAEAELSGELSGLGAL----PARRDLTLELEEPPQGPL----PRGSQRSEQLELERA 784
+A+A E GL + R LT ELE+ Q L + + E+L E
Sbjct: 736 RLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELL 795
Query: 785 LKLQPCASEKRAQM 798
K Q E R +M
Sbjct: 796 EKHQRELQEGREKM 809
Score = 67.8 bits (164), Expect = 7e-11
Identities = 210/1058 (19%), Positives = 406/1058 (38%), Gaps = 148/1058 (13%)
Query: 408 ERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS---EVEA-------E 457
ER + E+ ++ +++L + ++ QG RL L S EVEA E
Sbjct: 537 ERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGRVLRLPLKNSPSEEVEANSGGIEPE 596
Query: 458 RELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRL---QKEIVEVVEKLSDS 514
L E+ + ++E ++ Q +E R+ L L+ ++ +K++ E V +
Sbjct: 597 HGLGSEECNPLNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKA 656
Query: 515 ERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE--YELKCRDLQDRND------ 566
+ + ++ L+ ++ E+ A+ + AAVLKE +E CR +++
Sbjct: 657 QENMKQRHENETHTLEKQISDLKNEI-AELQGQAAVLKEAHHEATCRHEEEKKQLQVKLE 715
Query: 567 ----------------ELQAELEGLWARLPKNRH---SPSWSPD---GRRRQLPGLGPAG 604
EL+A L A + R S +W+ + G ++L
Sbjct: 716 EEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQ 775
Query: 605 ISFLGNSAPVSIETELMMEQVKEHYQDL---RTQLETKVNYYEREIAA------------ 649
++ L + E EL E +++H ++L R ++ET+ N +I A
Sbjct: 776 LTSLVEKHTLEKE-ELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTER 834
Query: 650 -------LKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTAR 702
L+ + +E KD+++ +R E S E +K +L + ++QE++ ++ + T+
Sbjct: 835 CESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSL 894
Query: 703 GPEPEQMGLAPCCTQALCGLALRHHSHLQQI---RREAEAELSGELSGLGALPARRDLTL 759
E+ L + L + + LQ + R +E + S L L +
Sbjct: 895 VLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSETQQS--LLSDQILELKSSHKR 952
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDG 819
EL E + G+ SEQL +R +L+ ++R +M +S L E + A + D
Sbjct: 953 ELREREEVLCQAGA--SEQLASQRLERLEMEHDQERQEM-MSKLLAMENIHKATCETADR 1009
Query: 820 PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGC---GERPLAWLAPGDGRESEEAAGAG 876
E + + Q+ T L L+ GC GE + GDG S G
Sbjct: 1010 ERAEMSTEISRLQSKIKEM-QQATSPLSMLQSGCQVIGEEEVE----GDGALSLLQQGEQ 1064
Query: 877 PRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQP 936
+ Q + + SR+Q ++ EP ++ L++P
Sbjct: 1065 LLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQR-------LQKLEPGLVMSSCLDEP 1117
Query: 937 GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASE 996
A QT+P + + + + L ++++ R
Sbjct: 1118 ATEFFG-----NTAEQTEPFLQQNRTKQVEGVT-RRHVLSDLEDDEVRDLGSTGTSSVQR 1171
Query: 997 QQAR---AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
Q+ + +E ++E + E R S Q++ Q A + K
Sbjct: 1172 QEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQEQLMMLCADCDRASEK----- 1226
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
K D+ + L+ ++ LE+ + +L + +S EN L ++EL E+
Sbjct: 1227 -KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL-------QEELRMMETR 1278
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
+D E L+ +KE EV Q++ K + ++ L L + + +NEE
Sbjct: 1279 YD------EALENNKELTA---EVFRLQDELKK--MEEVTETFLSLEKSYDEVKIENEEL 1327
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQV 1233
V + L +E++ S Q+ D LE L E L +L QTLEE +V
Sbjct: 1328 NVLVLRLQGKIEKLQESVVQRCD-CCLWEASLENLEIEPDGNIL---QLNQTLEECVPRV 1383
Query: 1234 QGAHLRLRQAQAQ------HLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287
+ H + + + + + Q + V +A LH + E+ R + EE+
Sbjct: 1384 RSVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTL 1443
Query: 1288 LKATEERVEEAEMI--LKNMEMLLQEKVDKLKEQF-------------EKNTKSDLLLKE 1332
L ++ + I L+ + LQE KLKE+ EK + ++ +
Sbjct: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
L + + + + ++ + ++++ +L ++ LN+
Sbjct: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNE 1541
Score = 62.8 bits (151), Expect = 2e-09
Identities = 83/356 (23%), Positives = 152/356 (42%), Gaps = 68/356 (19%)
Query: 1014 VEVARRGSLPSH--LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA 1071
V+ + SL H + Q SW+ Q A+ L+ + + K+ +LED V+
Sbjct: 1733 VDKLAKSSLLEHRIATMKQEQKSWEHQSAS---------LKSQLVASQEKVQNLEDTVQN 1783
Query: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE--------STHDA----QRK 1119
+ + ++D +E LK ++ + ++L+ A +TH + Q+K
Sbjct: 1784 VNLQMSRMKSD---LRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQK 1840
Query: 1120 EIE------VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA-STHQAQ--- 1169
+ ++ ++++ E E L QN K +L+ +V QL HQ
Sbjct: 1841 RLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNP 1900
Query: 1170 ------NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
E+ +++++ ++ ++ Q+ L ELE ++ E++ L+ +L
Sbjct: 1901 SGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLD 1960
Query: 1224 QTLEESQDQVQGA---------HLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274
+ L E Q A L+L Q QA +VP+++ +L R L LQ E+
Sbjct: 1961 EQLMEMQHLRSTATPSPSPHAWDLQLLQQQA-----CPMVPREQFLQLQRQL-LQAERIN 2014
Query: 1275 RRLDAQREEH-----------EKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQ 1319
+ L + E E+ + EER+ E E LK ++ LLQEKV++LKEQ
Sbjct: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQ 2070
Score = 54.7 bits (130), Expect = 6e-07
Identities = 81/385 (21%), Positives = 153/385 (39%), Gaps = 72/385 (18%)
Query: 1053 REKDDMETKLLHLEDVVRALEKHVD-----LRENDRLEFHRLSEEN----TLLKNDLGRV 1103
REK+ + + L E + + VD + + +L EE LKN+L +
Sbjct: 387 REKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKE 446
Query: 1104 RQE-LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ---- 1158
R++ L+ A +EIE K ++ + + ++N +++L + ++ +
Sbjct: 447 REQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENL 506
Query: 1159 -----------LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
L ++ + E + + LTQ E R + DQ+ +L+ ELE
Sbjct: 507 TNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEE 566
Query: 1208 LNQEHQSLQLPW-SELTQTLEESQDQVQGAH-----------------LRLRQAQAQHLQ 1249
+ + L+LP + ++ +E + ++ H L + Q + QH +
Sbjct: 567 YRAQGRVLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHR 626
Query: 1250 EV---RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNME 1306
++ RL +D+V + L ++ + ++ HE + E+++ + LKN
Sbjct: 627 DICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISD----LKNEI 682
Query: 1307 MLLQEKVDKLKEQFEKNT------KSDLLLKELYVENAHLVRAL---------------Q 1345
LQ + LKE + T K L +K L E HL L Q
Sbjct: 683 AELQGQAAVLKEAHHEATCRHEEEKKQLQVK-LEEEKTHLQEKLRLQHEMELKARLTQAQ 741
Query: 1346 ATEEKQRGAEKQSRLLEEKVRALNK 1370
A+ E++R + S EEKVR L +
Sbjct: 742 ASFEREREGLQSSAWTEEKVRGLTQ 766
Score = 52.4 bits (124), Expect = 3e-06
Identities = 94/440 (21%), Positives = 180/440 (40%), Gaps = 60/440 (13%)
Query: 966 ASCRGQAERLQA---IQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSL 1022
A+CR + E+ Q ++EE+ + + E +AR A + S E R G
Sbjct: 699 ATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQA------QASFEREREGLQ 752
Query: 1023 PSHLQLADPQGSWQE-------QLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075
S +G QE QL + E T E K+ +E L++ +E
Sbjct: 753 SSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQEGREKMETE 812
Query: 1076 VDLREND-----RLEFHRLSEE-NTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKE 1129
+ R + + + +++E + L++ GR RQEL+ + ++ + E K +
Sbjct: 813 CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELT 872
Query: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR----VTIQMLTQSLE 1185
+ C+E + L K+ L + L L QE + +EH V Q L Q LE
Sbjct: 873 QECAEAQEL------LKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 926
Query: 1186 EVVRSGQQQ----SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLR 1241
++ + Q SDQI +L+ S + E + L ++ Q A RL
Sbjct: 927 DLRNVSETQQSLLSDQILELK----------SSHKRELREREEVLCQAGASEQLASQRLE 976
Query: 1242 QAQAQHLQEVRLVPQDRVAELHRLLSLQG--EQARRRLDAQREEHEKQLKATEERVEEAE 1299
+ + +H Q+R + +LL+++ + D +R E ++ + +++E +
Sbjct: 977 RLEMEH-------DQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQ 1029
Query: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLL--KELYVENAHLVRALQATEEKQRGAEKQ 1357
+ ML +E+ E + LL ++L EN ++ +LQ E+ A K+
Sbjct: 1030 QATSPLSMLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQ---AVKE 1086
Query: 1358 SRLLEEKVRALNKLVSRIAP 1377
+ + ++ L + + ++ P
Sbjct: 1087 NVKMATEISRLQQRLQKLEP 1106
Score = 48.9 bits (115), Expect = 3e-05
Identities = 81/382 (21%), Positives = 161/382 (42%), Gaps = 75/382 (19%)
Query: 1026 LQLADPQGSWQEQLAAPEEGETKIA-LEREKDDMETKLLHLEDVVRALEKHVDLR----- 1079
L D Q +A E +TK+ L R+ + T L+ +DV+ EK +L+
Sbjct: 1444 LGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHD 1503
Query: 1080 ------------ENDRLEFHRLSEENTLLKNDLGR------------------------- 1102
E R E +L +EN++L+N++
Sbjct: 1504 LQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQK 1563
Query: 1103 ---VRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQL 1159
V+QE A + + +K+I LK ++ E L+++N +++L +LN R+ ++
Sbjct: 1564 TETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM 1623
Query: 1160 ----------------GQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK--- 1200
QE + + E +V L SLE + + Q+ +Q+
Sbjct: 1624 LCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENH 1683
Query: 1201 -LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQE-VRLVPQDR 1258
L+ ELE + Q H+ L S+ Q + S L+ ++A ++ L V + +
Sbjct: 1684 LLKDELEKMKQLHRCPDL--SDFQQKI-SSVLSYNEKLLKEKEALSEELNSCVDKLAKSS 1740
Query: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK- 1317
+ E HR+ +++ EQ + + Q + QL A++E+V+ E ++N+ + + L+
Sbjct: 1741 LLE-HRIATMKQEQ--KSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRV 1797
Query: 1318 -EQFEKNTKSDLLLKELYVENA 1338
+Q ++ K +++ ++NA
Sbjct: 1798 TQQEKEALKQEVMSLHKQLQNA 1819
Score = 38.1 bits (87), Expect = 0.059
Identities = 52/247 (21%), Positives = 108/247 (43%), Gaps = 25/247 (10%)
Query: 333 QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMT--VDSAVQQAALACYHQELS--- 387
Q +Q GRE +++ + + + +E + D + +T +SA+Q Y QEL
Sbjct: 799 QRELQEGREKMET---ECNRRTSQIEAQFQSDCQKVTERCESALQSLE-GRYRQELKDLQ 854
Query: 388 -YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRER 446
Q+ + Q E+D+ Q+ A+ E +KE T + ++ + LE+ Y+E
Sbjct: 855 EQQREEKSQWEFEKDELTQECAEAQ----ELLKETLKREKTTSLVLTQEREMLEKTYKEH 910
Query: 447 LSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVE 506
L + + ER+ + R E +++ L +++ + R +E E
Sbjct: 911 L----NSMVVERQQLLQDLEDLRNVSE-------TQQSLLSDQILELKSSHKRELREREE 959
Query: 507 VVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566
V+ + SE+LA + + LE + + ++LLA E A + + + ++
Sbjct: 960 VLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEIS 1019
Query: 567 ELQAELE 573
LQ++++
Sbjct: 1020 RLQSKIK 1026
Score = 37.0 bits (84), Expect = 0.13
Identities = 74/355 (20%), Positives = 137/355 (38%), Gaps = 33/355 (9%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
QE + Q VE L ++ + + ++ + N E ++ L++L ++ + L Q
Sbjct: 1569 QENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQKE 1628
Query: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKE 503
+E + E E E+ E+ R + V L+AE + ++ + + +EN L+ E
Sbjct: 1629 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDE 1688
Query: 504 IVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQD 563
+ EK+ R DL + + + +L+ E+ +LKE E +L
Sbjct: 1689 L----EKMKQLHRCP-----DLS-----DFQQKISSVLSYNEK---LLKEKEALSEELNS 1731
Query: 564 RNDELQAE--LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621
D+L LE A + + + S + QL A + N L
Sbjct: 1732 CVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLV----ASQEKVQNLEDTVQNVNLQ 1787
Query: 622 MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER-KDMEQARRREVSVLEGQKA--- 677
M ++K DLR + K ++E+ +L + + K S L Q+
Sbjct: 1788 MSRMKS---DLRVTQQEK-EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1843
Query: 678 --DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL 730
L+ L + Q+++W E+LQ + + E Q L +H HL
Sbjct: 1844 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1898
Score = 35.8 bits (81), Expect = 0.29
Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 36/220 (16%)
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
S HQA + I+ L + +++VVR + +KLR +L+ +E
Sbjct: 362 SIHQAALASFKAEIRHLLERVDQVVR-------EKEKLRSDLD------------KAEKL 402
Query: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283
++L S +V H + + +L+++ ++R+A L L + EQ ++ QR E
Sbjct: 403 KSLMAS--EVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGKQRLE 460
Query: 1284 HEKQLK--ATEERVEEAEMIL-----KNMEMLLQEKVDKLKE------QFEKNTKSDLLL 1330
E++++ TEE + L +E L E +KL E + ++N ++ L
Sbjct: 461 LEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNLENVLAE 520
Query: 1331 K--ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
K +L +A + + + E+Q R+L+++V L
Sbjct: 521 KFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDEL 560
Score = 35.8 bits (81), Expect = 0.29
Identities = 65/340 (19%), Positives = 134/340 (39%), Gaps = 55/340 (16%)
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091
Q EQLA+ ++ ++E+ +M +KLL +E++ +A + D
Sbjct: 963 QAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD-------------- 1008
Query: 1092 ENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQ 1151
R R E+ S ++ KE++ S +V+ + LS
Sbjct: 1009 ----------RERAEMSTEISRLQSKIKEMQQATSPLSMLQSGCQVIGEEEVEGDGALS- 1057
Query: 1152 LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQE 1211
+LQ G++ EE+ + L ++ E+ V+ + + +I +L+ L+ L
Sbjct: 1058 ----LLQQGEQLL------EENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLE-- 1105
Query: 1212 HQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGE 1271
P ++ L+E + G + LQ+ R + V H L L+ +
Sbjct: 1106 ------PGLVMSSCLDEPATEFFG---NTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDD 1156
Query: 1272 QARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331
+ R ++Q E ++EE+E ++ L+ + E +E + L +
Sbjct: 1157 EVRDLGSTGTSSVQRQ----EVKIEESEASVEGFSE-LENSEETRTESWELKNQISQLQE 1211
Query: 1332 ELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371
+L + A RA EK++ +L++K++ L ++
Sbjct: 1212 QLMMLCADCDRA----SEKKQDLLFDVSVLKKKLKMLERI 1247
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1716
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1777 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2072 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2127
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2128 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2184
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2243
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2358
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2359 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2476
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2535
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2592
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2593 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2627
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1161 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1217 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1271
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1272 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1387
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1440
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1441 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1556
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1613
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1731
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1850 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1899
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1960 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 1996
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQ 2078
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1393
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1394 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1448
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1509 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1559
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1560 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1675 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1713
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1076 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1135
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1191
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1192 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1242
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1243 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1301
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1302 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1355
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1476 QALRAR 1481
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2420 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2538
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2599 ----QLLEEQHRAAL 2609
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1720
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1781 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2076 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2131
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2132 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2188
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2247
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2362
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2363 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2422 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2480
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2539
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2540 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2596
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2597 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2631
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1165 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1220
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1221 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1275
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1276 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1391
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1444
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1445 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1560
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1561 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1617
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1735
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1854 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1903
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1963
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1964 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 2000
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQ 2082
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1342 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1397
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1398 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1452
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1513 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1563
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1564 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1679 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1717
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1080 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1139
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1140 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1195
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1196 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1246
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1247 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1305
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1306 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1359
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1419
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1480 QALRAR 1485
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2424 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2483
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2542
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2543 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2603 ----QLLEEQHRAAL 2613
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1716
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1777 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2072 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2127
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2128 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2184
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2243
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2358
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2359 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2418 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2476
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2535
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2592
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2593 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2627
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1161 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1217 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1271
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1272 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1387
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1440
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1441 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1556
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1557 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1613
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1731
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1850 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1899
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1959
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1960 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 1996
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQ 2078
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1393
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1394 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1448
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1509 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1559
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1560 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1675 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1713
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1076 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1135
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1136 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1191
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1192 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1242
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1243 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1301
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1302 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1355
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1476 QALRAR 1481
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2420 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2538
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2599 ----QLLEEQHRAAL 2609
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1684
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1745 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2040 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2095
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2096 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2152
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2153 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2211
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2326
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2327 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2386 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2444
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2503
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2504 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2560
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2561 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2595
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1129 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1184
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1185 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1239
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1240 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1355
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1408
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1409 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1524
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1525 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1581
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1699
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1818 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1867
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1927
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1928 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 1964
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQ 2046
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1306 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1361
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1362 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1416
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1477 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1527
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1528 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1643 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1681
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1044 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1103
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1104 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1159
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1160 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1210
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1211 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1269
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1270 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1323
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1444 QALRAR 1449
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2388 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2447
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2506
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2507 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2567 ----QLLEEQHRAAL 2577
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1853
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1914 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2209 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2264
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2265 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2321
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2380
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2495
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2496 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2555 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2613
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2672
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2673 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2729
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2730 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2764
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1298 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1353
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1354 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1408
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1409 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1524
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1577
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1578 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1693
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1750
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1751 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1868
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1987 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 2036
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 2096
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 2097 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 2133
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQ 2215
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1475 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1530
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1531 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1585
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1646 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1696
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1697 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1812 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1850
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1213 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1272
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1273 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1328
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1329 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1379
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1380 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1438
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1439 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1492
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1552
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1613 QALRAR 1618
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2557 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2616
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2675
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2676 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2736 ----QLLEEQHRAAL 2746
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1694
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1755 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2050 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2105
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2106 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2162
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2163 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2221
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2336
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2337 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2396 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2454
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2513
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2514 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2570
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2571 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2605
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1139 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1194
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1195 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1249
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1250 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1365
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1418
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1419 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1534
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1591
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1592 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1709
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1710 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1828 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1877
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1937
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1938 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 1974
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQ 2056
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1316 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1371
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1372 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1426
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1487 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1537
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1538 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1653 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1691
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1054 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1113
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1114 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1169
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1170 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1220
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1221 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1279
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1280 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1333
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1454 QALRAR 1459
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2398 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2457
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2516
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2517 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2577 ----QLLEEQHRAAL 2587
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1702
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1763 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2058 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2113
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2114 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2170
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2171 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2229
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2344
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2345 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2404 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2462
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2521
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2522 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2578
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2579 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2613
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1147 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1202
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1203 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1257
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1258 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1314
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1373
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1426
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1427 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1485
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1486 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1542
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1543 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1599
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1600 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1717
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1718 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1836 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1885
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1945
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1946 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 1982
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQ 2064
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1324 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1379
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1380 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1434
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1495 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1545
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1546 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1600
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1661 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1699
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1062 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1121
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1122 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1177
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1178 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1228
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1229 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1287
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1288 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1341
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1401
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1462 QALRAR 1467
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2406 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2465
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2524
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2525 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2585 ----QLLEEQHRAAL 2595
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 122 bits (306), Expect = 2e-27
Identities = 213/1059 (20%), Positives = 425/1059 (40%), Gaps = 86/1059 (8%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK--------------- 419
+ A+A +E + Q + R R++A ++LER + + E ++
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 420 --EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVG 477
E + E+ ++ K EQ R+R L E+E +R+L E +QR A E ++
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLA-EGTAQQRLAAEQELI 1743
Query: 478 RLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQS 537
RL+AE ++ L +E +RLQ+E +K + E K++ ++E +L K +
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Query: 538 AELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E+ L+ + R+L E A L L + R +R +
Sbjct: 1804 -ESRSTSEKSKQRLEAEAGRFRELA----EEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV---NYYEREIAALKRNF 654
+ ++ +G + + E E+ +++ + + LR E + E + A K +
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
E+ + +A E+ +G D + +E I L+ + A G ++ L
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 715 CTQALCGLALRHHSHL------------QQIRREAEAELSGELSGLGALPARRDLTLELE 762
+ A L + + L ++ RREAE + L+ +R LE
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 763 EPPQGPLPRGSQRSEQLELERALKLQPC--ASEKRAQ---MCVSLALEEEELELARGKRV 817
E + + + E+ E E A +LQ A++KR Q + A++++E EL + +
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGP 877
+ L+ +++ + A E R + R R A + +EE A A
Sbjct: 2099 EQSVLD-QLRGEAEAARRAAEEAEEAR-VQAEREAAQSRRQVEEAERLKQSAEEQAQA-- 2154
Query: 878 RRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
R QAQ A +E+ + Q D ++ ++ + F +
Sbjct: 2155 -RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM--EKHKKFAEQTLRQKAQV 2211
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
+EL L + + + Q + + L+ + +A R ++ EE S R E+ S+
Sbjct: 2212 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-VRVQMEELSKL 2270
Query: 998 QARAEGA-----------LEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE 1046
+AR E + + + ++ + + L +A + + QLA + +
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 1047 TKIALE---REKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
+ E +EK + L+ L++ +L + + RL E+ + L
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE---QARRLQEDKEQMAQQLA-- 2385
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
+E + + T +A+R+ + + E+ + ++R ++ + + ++G++
Sbjct: 2386 -EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+ +E +Q L ++ ++ + I +L E E L QE + LQL SE
Sbjct: 2445 HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-SEEM 2503
Query: 1224 QTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS---LQGEQARRRLD 1278
QT+++ Q + Q + LQ R + Q++ A+L +L + +Q R
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQ 2562
Query: 1279 AQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
Q+++ E++ + +EEA E ++ K ++L++ ++ + + LL E EN
Sbjct: 2563 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE---ENQ 2619
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAP 1377
L LQ EE+ R A S E+V A ++ P
Sbjct: 2620 RLREQLQLLEEQHRAALAHS----EEVTASQVAATKTLP 2654
Score = 96.3 bits (238), Expect = 2e-19
Identities = 215/982 (21%), Positives = 389/982 (39%), Gaps = 119/982 (12%)
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL-EWDVGRLQAEEAGLR-------- 487
+ L+Q + ER EVE RE + R +A L + DV + + E+ G +
Sbjct: 1188 ERLQQRHGER----DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1243
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
+ L L++ R Q++I + L+DS+ + +L++ E L +++E + E + + +RF
Sbjct: 1244 DPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQ--EQALLEEIE-RHGEKVEECQRF 1298
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR-HSPSWSP-----DGRRR--QLPG 599
A K+Y +D + + +A+LE + + K + S S S D R +L
Sbjct: 1299 A---KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1355
Query: 600 LGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAAL----KRNFE 655
L I F+ + E E + EQ + ++ ++E + +R++A K E
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1414
Query: 656 KERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCC 715
+E K+++Q + EV E D ++ +QE+LQ + E E A
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRS-------IQEELQQLRQSSEAEIQAKARQA 1467
Query: 716 TQALCGLALRHHSHLQQIRREAEAE------LSGELSGLGA----LPARRDLTLELEEPP 765
+A LR ++ +R + EA GEL L A A++ E E
Sbjct: 1468 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
Query: 766 QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAE 825
+ + SQR Q E+E A +++ A R + ALEE L+ +R +AE
Sbjct: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER---RLRQAE 1583
Query: 826 MQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDT 885
++ + + + Q L + A L + EE R +A+
Sbjct: 1584 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERR 1640
Query: 886 EATQSPAPAPAPASHGPSERW----SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAREL 941
Q+ A + ERW + + + V ++ A A ++ RE
Sbjct: 1641 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700
Query: 942 PLLGTERDASQTQPRMWEPPL-RPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
G + + Q + E L + G A++ A ++E R R EQ +Q+
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--LRAETEQGEQQRQL 1758
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA--APEEGETKIALEREKDDM 1058
E L + + +R L + +LA + + LA A E E++ E+ K +
Sbjct: 1759 LEEELARLQREAAAATQKRQELEA--ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816
Query: 1059 ETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQR 1118
E + ++ + L E + + E+ + + RV E AA +
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
E E+ K+KE +E E L R ++ Q +L ++A+ H+A EE ++
Sbjct: 1877 TEAEIALKEKE---AENERLRRLAEDEAFQRRRLE-------EQAAQHKADIEERLAQLR 1926
Query: 1179 MLTQS--------LEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQ 1230
+ S +E+ +R +Q ++I L+ E L+L + E++
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTL 1986
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A L E R L E+ RRR +A+ E +K L A
Sbjct: 1987 RSKEQAEL----------------------EAARQRQLAAEEERRRREAE-ERVQKSLAA 2023
Query: 1291 TEERVEEAEMILKNMEMLLQ--EKVDKLKEQFEKNTKSDLLL------KELYV-ENAHLV 1341
EE + + L+ +E L E+ +L+E+ E+ + L L K L E AH
Sbjct: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083
Query: 1342 RALQATEEKQRGAEKQSRLLEE 1363
Q +E Q+ +++ +L++
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQ 2105
Score = 74.3 bits (181), Expect = 7e-13
Identities = 101/401 (25%), Positives = 173/401 (43%), Gaps = 33/401 (8%)
Query: 972 AERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
+E L+ ++EE + + +E+ E+ A E ALE + E + + + +
Sbjct: 1365 SETLRRMEEEERLAEQQRAEER--ERLAEVEAALEK--QRQLAEAHAQAKAQAEREAKEL 1420
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHL----EDVVRALEKHVDLRENDRLEFH 1087
Q QE++ EE + +++K ++ +L L E ++A + + E RL
Sbjct: 1421 QQRMQEEVVRREEAA--VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL--- 1475
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
R+ EE +++ L ++ AE A R E + K +A E E L RQ Q+
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC 1207
+ Q V + AS +A+ E R Q Q+LEE+ ++ ++++ E+E
Sbjct: 1536 RKRQAEVEL------ASRVKAEAEAAREK-QRALQALEELRLQAEEAERRLRQ--AEVER 1586
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH-LQEVRLVPQDRVAELHRLL 1266
Q +L E Q E++ Q + A + AQ + LQE + E R
Sbjct: 1587 ARQVQVAL-----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641
Query: 1267 SLQGEQARRRLDAQREEHEKQLKATEE-RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK 1325
Q E R R +A+RE QLKA E R+ + + L Q + +K KE+ E+ +
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 1326 SDLLLKELYVENAHLVRALQATEEKQRGAE--KQSRLLEEK 1364
+E V L A Q E++++ AE Q RL E+
Sbjct: 1702 RRGKAEEQAVRQREL--AEQELEKQRQLAEGTAQQRLAAEQ 1740
Score = 53.9 bits (128), Expect = 1e-06
Identities = 96/426 (22%), Positives = 178/426 (41%), Gaps = 52/426 (12%)
Query: 971 QAERLQAIQEERARSWS---RGTQ----------EQASEQQARAEGALEPGCHKHSVEVA 1017
Q L AI E+ ++ S RGTQ EQ E QA E K S++
Sbjct: 1103 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1162
Query: 1018 R---RGSLPSHLQLADPQGSWQE--QLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
R P+ L D QE + GE + +ER ++ ++ L + +A+
Sbjct: 1163 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE----RVAQLLERWQAV 1218
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
D+R+ + + R + LG Q DA+R++ ++ +
Sbjct: 1219 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ---------DARRRQEQIQAMPLADSQ 1269
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ E L RQ Q +++ + +V + + A + +++ + + LE V +
Sbjct: 1270 AVREQL-RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK 1328
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVR 1252
+ K++ E + QE+ L+ +SELT TL + LR + + + ++ R
Sbjct: 1329 KP-----KVQSGSESVIQEYVDLRTHYSELT-TLTSQYIKFISETLRRMEEEERLAEQQR 1382
Query: 1253 LVPQDRVAELHRLLSLQGE----QARRRLDAQREEHEKQLKATEE--RVEEAEMILKNME 1306
++R+AE+ L Q + A+ + A+RE E Q + EE R EEA + + +
Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKEL-------YVENAHLVR-ALQATEEKQRGAEKQS 1358
+QE++ +L++ E ++ E E +VR L+ATE ++ GAE +
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 1359 RLLEEK 1364
+ L +
Sbjct: 1503 QALRAR 1508
Score = 39.3 bits (90), Expect = 0.026
Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 12/195 (6%)
Query: 332 TQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQG 391
T+ Q ++Q+L+ + + E EL +QQ A + Q
Sbjct: 2447 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2506
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q EQL +E +Q + L+ + ++ + LEQL + ++ +Q RE +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ-LREEQQRQQ 2565
Query: 452 SEVEAERELF---WEQAHRQRAALEWDVGRLQAE----EAGLREKLTLALKENSRLQKEI 504
++E ER+ E+A R++ E V R Q E E R++ L +EN RL++++
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Query: 505 VEVVEKLSDSERLAL 519
+ L + R AL
Sbjct: 2626 ----QLLEEQHRAAL 2636
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 110 bits (275), Expect = 9e-24
Identities = 229/1086 (21%), Positives = 442/1086 (40%), Gaps = 154/1086 (14%)
Query: 365 NELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDC 424
NE + +D L +E ++E + R+ + DL AEKR ++
Sbjct: 605 NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL 664
Query: 425 HSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEA 484
+ L++ E + L+ R+ ++ E E ++ E H+Q AA + +L E
Sbjct: 665 EAQLQKAEEAGAE-LQADLRD----IQEEKEEIQKKLSESRHQQEAATT-QLEQLHQEAK 718
Query: 485 GLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV--LKDKLEPQSAELLA 542
E L A++E L +E + +L ER L + L+ + K+ LE E
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQ 778
Query: 543 QEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGP 602
Q + E++ + + + +Q E+ L L R D RQL
Sbjct: 779 QNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQL----- 833
Query: 603 AGISFLGNSAPVSIETELMMEQVKEHYQ----DLRTQLETKVNYYEREIAALKRNFEKER 658
A E + +EQ K ++ LR + E + +++++E+A + E+E+
Sbjct: 834 ---------AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREK 884
Query: 659 KDMEQARRREVSVLEGQKADLEELHEKSQ------------------EVIWGLQEQLQDT 700
++E + + + +E +A EE +++ E + Q++L D
Sbjct: 885 MELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADA 944
Query: 701 ARGPEP--EQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGL-----GALPA 753
++ E + M + Q G+ Q+ +EA + +L+ L L
Sbjct: 945 SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 754 RRDLTLELEE-PPQGPLPRGSQRSEQLELERALK-------LQPCASEKRAQMCVSLALE 805
+ DL ++E+ Q SQR + E++ L+ +Q ++A + +SL +
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 806 EEELELARGKRVDGPSL-EAEMQALPKDGLVA-GSGQEGTRGLLPLRPGCGERPLAWLAP 863
E+ L + + + S+ + E+ AL +D A G +E + + LR E+ +LA
Sbjct: 1065 EQRLLVLQ----EADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQ 1120
Query: 864 GDGRESEEAAGAGPRRRQ------AQDTEA---------TQSPAPAPAPASHGPSERWSR 908
+ + EE + +Q AQ+ +A T+S A A ++ ++
Sbjct: 1121 -EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179
Query: 909 MQPCGVD-------GDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPP 961
Q + G + PE S G P + G E D + + P
Sbjct: 1180 AQLASLYSALQQALGSVCESRPE---LSGGGDSAPS-----VWGLEPDQNGARSLFKRGP 1231
Query: 962 LRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGAL-EPGCHKHSVEVARRG 1020
L A S A L + ++ ++ + T++ +Q + E L + K V
Sbjct: 1232 LLTALSAEAVASALHKLHQDLWKT--QQTRDVLRDQVQKLEERLTDTEAEKSQV------ 1283
Query: 1021 SLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRE 1080
H +L D Q QL+ +E ++K E +++ +E++L+ L + + +L+ + E
Sbjct: 1284 ----HTELQD----LQRQLSQNQEEKSK--WEGKQNSLESELMELHETMASLQSRLRRAE 1333
Query: 1081 NDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNR 1140
R+E E K +L + L+AA AQ +L++D A S +++ N
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393
Query: 1141 QNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK 1200
+ ++ ++ R L ++ AQ + + + +LTQ+L E + ++++
Sbjct: 1394 EVESERE-------RAQALQEQGELKVAQGKALQENLALLTQTLAE-------REEEVET 1439
Query: 1201 LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQD--- 1257
LR +++ L ++ + + L+ L++ +V L+Q Q Q L++ R V +
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVD-----LQQEQIQELEKCRSVLEHLPM 1494
Query: 1258 RVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLK 1317
V E + L++Q EQ R L+ RE L+ +E+ + ++++ + +V LK
Sbjct: 1495 AVQEREQKLTVQREQI-RELEKDRETQRNVLEHQLLELEKKDQMIESQ----RGQVQDLK 1549
Query: 1318 EQFEKNTKSDLLLKELYVENAH-------LVRALQATEEKQRGAEKQSRL-LEEKVRALN 1369
+Q + L EL EN H L++ L+ E QR A L LEE+ + L
Sbjct: 1550 KQL---VTLECLALEL-EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605
Query: 1370 KLVSRI 1375
S+I
Sbjct: 1606 AQSSQI 1611
Score = 109 bits (273), Expect = 2e-23
Identities = 274/1173 (23%), Positives = 462/1173 (39%), Gaps = 258/1173 (21%)
Query: 334 EGIQNGREILQSLDFSVDEKVNLLELT-WALDNELMTVDSA--VQQAALACYHQELSYQQ 390
+G+ + +E+L+S F ++ +++E+T L+ ++ TV A V Q + C EL ++
Sbjct: 760 QGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTER 819
Query: 391 GQVEQLARERDKARQDLERAEKRNLEFVKEMDDCH-STLEQLTEKKIK----HLEQGYRE 445
Q EQ ERD A + L +AE+ +++ H + QL EK K H ++ +
Sbjct: 820 SQAEQ---ERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 446 RLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIV 505
SL R ++E E L +Q + + + R QAE A + +L KE L + ++
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETE-KERVSLLETLL 935
Query: 506 EVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRD----- 560
+ ++L+D+ + +L++D++ V K K + + L Q + LKE + RD
Sbjct: 936 QTQKELADASQQLERLRQDMK-VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL 994
Query: 561 -------LQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAP 613
LQD+ D LQ ++E L ++L D +R
Sbjct: 995 QEESSSLLQDKMD-LQKQVEDLKSQLVA-------QDDSQR------------------- 1027
Query: 614 VSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLE 673
+E E + E+++E + R Q E ERE A+L + ME+ +R V
Sbjct: 1028 -LVEQE-VQEKLRETQEYNRIQKE-----LEREKASLTLSL------MEKEQRLLV---- 1070
Query: 674 GQKADLEELHEKSQEVIWGLQEQLQDTARGPEPE---QMGLAPCCTQALCGLALRHHSHL 730
L+E Q+ + L++ +Q+ A+G + E QM L L
Sbjct: 1071 -----LQEADSIRQQELSALRQDMQE-AQGEQKELSAQMEL------------------L 1106
Query: 731 QQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPC 790
+Q +E EA+ L L ELE S +EQ +L +L Q
Sbjct: 1107 RQEVKEKEADF---------LAQEAQLLEELE---------ASHITEQ-QLRASLWAQ-- 1145
Query: 791 ASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLR 850
K AQ+ + L E +LE ++ G +A+ Q + + Q+ + R
Sbjct: 1146 -EAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL----ASLYSALQQALGSVCESR 1200
Query: 851 P----GCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHG-PSER 905
P G P W D + GP T A A A A H +
Sbjct: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPL--------LTALSAEAVASALHKLHQDL 1252
Query: 906 WSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWE------ 959
W Q V D V K E + A Q EL L + +Q + WE
Sbjct: 1253 WKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT-ELQDLQRQLSQNQEEKSKWEGKQNSL 1311
Query: 960 ---------------PPLRPA----ASCRGQAERLQAIQEERARSWSRGTQEQASEQQAR 1000
LR A +G+ E LQA +E ++ QA+ +AR
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT---AQVEHLQAAVVEAR 1368
Query: 1001 AEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIA---------- 1050
A+ A G + + AR L+ + + + A E+GE K+A
Sbjct: 1369 AQ-ASAAGILEEDLRTARSA---LKLKNEEVESERERAQALQEQGELKVAQGKALQENLA 1424
Query: 1051 -----LEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLK---NDLGR 1102
L ++++ET ++++ + E E L+ + ++E L + +L +
Sbjct: 1425 LLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEK 1484
Query: 1103 VRQELE-------AAESTHDAQRKEIEVLKKDK--------------EKACSEMEVLNRQ 1141
R LE E QR++I L+KD+ EK +E Q
Sbjct: 1485 CRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQ 1544
Query: 1142 NQNYKDQLSQLNVRVLQLGQEASTH------------QAQNEEHRVTIQMLTQSLEEVVR 1189
Q+ K QL L L+L E + H + Q E RV + LT LEE +
Sbjct: 1545 VQDLKKQLVTLECLALEL--EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
Query: 1190 SGQQQSDQIQKLR--------------VELECLNQEHQSLQLPWSELTQTLEESQDQVQG 1235
Q QS QI L E++ ++ + LQ LTQ LE ++
Sbjct: 1603 ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELML 1662
Query: 1236 AHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQ---ARRRLDAQREEHEKQLKATE 1292
R++ + Q ++ +++ +D + ++ L +G + R+ + + EE + KA
Sbjct: 1663 QKERIQVLEDQRTRQTKILEED-LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQR 1721
Query: 1293 ERVEEAEMILKNMEM----------LLQEKVDKLKEQFE----KNTKSDLLLKELYVENA 1338
+E ++IL++ E LQE D+L++Q + K ++ LLL + E
Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 1339 HLVRALQATEEKQRGAEKQSRL---LEEKVRAL 1368
L + LQ E +++G K+ L L+E RAL
Sbjct: 1782 VLQQQLQ--EAREQGELKEQSLQSQLDEAQRAL 1812
Score = 97.1 bits (240), Expect = 1e-19
Identities = 269/1278 (21%), Positives = 496/1278 (38%), Gaps = 184/1278 (14%)
Query: 123 EARRVPEQQTQASLKSHLWRSASLE-SVESPKSDEEAESTKEAQNELFEAQGQLQTWDS- 180
EA + EQQ +ASL + ++A L+ + S +S EA + ++ +AQ QL + S
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Query: 181 --EDFGSPQKSCSPSFDTPESQIRGVW----------------------EELGVGSSGHL 216
+ GS +S P VW V S+ H
Sbjct: 1189 LQQALGSVCES-RPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 217 SEQELAVVCQSVGL-----QGLEKE-------------ELEDLFNKLDQDGDGKVSLEEF 258
Q+L Q+ + Q LE+ EL+DL +L Q+ + K E
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 259 QLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLR-LFSSIDD 317
Q L S E L E+ ++ + Q E G ++ +L + + L +++ +
Sbjct: 1308 QNSLES-ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366
Query: 318 GSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVD---EKVNLLELTWAL---DNELMTVD 371
A +L +E ++ R L+ + V+ E+ L+ L + + +
Sbjct: 1367 ARAQASAAGIL----EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN 1422
Query: 372 SAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERA----EKRNLEF------VKEM 421
A+ LA +E+ +GQ+++L ++R+ + LE +KRN E ++E+
Sbjct: 1423 LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
Query: 422 DDCHSTLEQLTEKKIKHLEQGY---RERLSLLRSEVEAERELFWEQA---HRQRAALEWD 475
+ C S LE L ++ EQ RE++ L + E +R + Q ++ +E
Sbjct: 1483 EKCRSVLEHLP-MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQ 1541
Query: 476 VGRLQAEEAGL--REKLTLALKENSR---LQKEIVEVVEKLSDSERLALKLQKDLEFVLK 530
G++Q + L E L L L+EN Q+++++ +E +++R+AL L
Sbjct: 1542 RGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH-------LT 1594
Query: 531 DKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSP 590
LE +S EL AQ + + + R+LQ+R+ E++++ E + L + + +
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI-EELQRQKEHLTQDL 1653
Query: 591 DGRRRQLPGLGPAGISFLGNSAPVSIETELM---MEQVKEHYQDLRTQLETKVNYYEREI 647
+ R ++L L I L + + +T+++ +EQ+K ++ +L T+ +
Sbjct: 1654 ERRDQELM-LQKERIQVLEDQR--TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 648 AALKRNFEKERKDME------QARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTA 701
K + +R +E + + +EV + +L+EL ++ ++ + GL ++ +T+
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
Query: 702 RGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAE---LSGELSGLGALPARRDLT 758
+ + Q LQ+ R + E + L +L A+RD
Sbjct: 1771 LLLSQREQEIVVLQQQ------------LQEAREQGELKEQSLQSQLDEAQRALAQRDQE 1818
Query: 759 LEL----EEPPQGPLPRGSQRSEQLE--LERA-LKLQPCASEKRAQMCVSLALEEEELEL 811
LE ++ QG R ++++ L+ LE+A + L+ E + + LEEE
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE---- 1874
Query: 812 ARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEE 871
V+G ++A + L G + +E + LL L+ C E+ +
Sbjct: 1875 ---LAVEGRRVQALEEVL---GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Query: 872 AAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAA 931
+ + Q+ EA ++ + + R +Q + E A
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA 1988
Query: 932 GLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQ 991
L + L DA Q R E LR IQE + Q
Sbjct: 1989 ELSRSLEASTATLQASLDACQAHSRQLEEALR--------------IQEGEIQDQDLRYQ 2034
Query: 992 EQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIAL 1051
E + Q E H+ E SL +Q + QE K L
Sbjct: 2035 EDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ----ENMIQE----------KQNL 2080
Query: 1052 EREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE 1111
+E+++ E + LH VR L+ + +E + LE + N LEA
Sbjct: 2081 GQEREEEEIRGLH--QSVRELQLTLAQKEQEILELRETQQRN------------NLEALP 2126
Query: 1112 STHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNE 1171
+H E + LK D S L R+ + + L Q R ++ ++A
Sbjct: 2127 HSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLA 2181
Query: 1172 EHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQD 1231
+ + ++ L + + S ++ + Q+L+ ELE + + +L T T E
Sbjct: 2182 QTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSR 2241
Query: 1232 QVQGAHL-RLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQR-EEHEKQLK 1289
QG L + +A+ + ++ + RL LQ AR +D R + H QL+
Sbjct: 2242 GEQGVQLGEVSGVEAEPSPD----GMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLR 2297
Query: 1290 ATEERVEEAEMILKNMEM 1307
+T E+VE LK M
Sbjct: 2298 STLEQVERERRKLKREAM 2315
Score = 68.9 bits (167), Expect = 3e-11
Identities = 103/430 (23%), Positives = 178/430 (41%), Gaps = 71/430 (16%)
Query: 997 QQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQ-GSWQEQLAAPEEGETKIALEREK 1055
Q+ +A+ + HS +AR LQ D + S +EQ+ + + + + E+
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARE------LQERDQEVKSQREQIEELQRQKEHLTQDLER 1655
Query: 1056 DDMETKLLHLEDVVRALE----KHVDLRENDRLEFHRLS--EENTLLKNDLGRVRQELEA 1109
D E L+ ++ ++ LE + + E D LE +LS E L +++ E
Sbjct: 1656 RDQE--LMLQKERIQVLEDQRTRQTKILEED-LEQIKLSLRERGRELTTQRQLMQERAEE 1712
Query: 1110 AESTHDAQRKEIEVLK-----KDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEAS 1164
+ AQR +E +K K+KE C + + + Q KDQL Q + + E S
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHI--HELQELKDQLEQQLQGLHRKVGETS 1770
Query: 1165 THQAQNEEHRVTIQMLTQSLEEV----VRSGQQQSDQIQKLRV----ELECLNQEHQSLQ 1216
+Q E+ V +Q Q E +S Q Q D+ Q+ ELE L QE Q Q
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830
Query: 1217 LPWSELTQTLEESQDQVQGAHLRLRQA---------QAQHLQEVRLVPQDRVAELHRLLS 1267
+ + + Q ++ AH+ L++ QA+ L+E V RV L +L
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG 1890
Query: 1268 LQGEQARRRLDA----------QREEHEKQLKATEERVEEAEMILK----NMEMLLQEKV 1313
++R + A Q +EHE + +A ++ +A+ +LK +E L E
Sbjct: 1891 DLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQ 1950
Query: 1314 DKLKEQFEKNTKSDLLLKEL-------------YVENAHLVRALQAT----EEKQRGAEK 1356
++ +++ L + L +E A L R+L+A+ + +
Sbjct: 1951 SSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQA 2010
Query: 1357 QSRLLEEKVR 1366
SR LEE +R
Sbjct: 2011 HSRQLEEALR 2020
Score = 61.2 bits (147), Expect = 6e-09
Identities = 105/489 (21%), Positives = 198/489 (40%), Gaps = 81/489 (16%)
Query: 927 GASAAGLEQPGARELPLLGTERD----------ASQTQPRMWEPPLRPAA-SCRGQAERL 975
G SA G ++ EL L ER+ A Q++ LR A S + E L
Sbjct: 500 GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 976 QAIQEERARSWSRGTQEQA----SEQQARAE------GALEPGCHKHSVEVARRGSLPSH 1025
+ Q E + +R Q A SE + E A++ ++ + + G
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619
Query: 1026 LQLADPQGSWQEQLAAPEEGETKIAL-----EREKDDMETKLLHLEDVVRALEKHVDLRE 1080
LQL + S ++ A E+ + + E+ ++ + K HLE L+K +
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE---AQLQKAEEAGA 676
Query: 1081 NDRLEFHRLSEENTLLKNDLGRVRQELEAA----ESTHDAQRKEIEVLKKD--------K 1128
+ + + EE ++ L R + EAA E H +++ EVL + +
Sbjct: 677 ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736
Query: 1129 EKACSE--MEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEE 1186
EKA E ++ + R Q+ +QL L+ L Q QN VT L ++
Sbjct: 737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 1187 VVRSGQQQSDQIQKLRVELEC-LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQA 1245
V ++ + +++ L++EL+ +Q Q +L Q +E + L Q +A
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK-------TALEQQKA 849
Query: 1246 QHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNM 1305
H +EV Q R + + +R H+++L E +E +M +
Sbjct: 850 AHEKEV-------------------NQLREKWEKERSWHQQELAKALESLEREKM---EL 887
Query: 1306 EMLLQEKVDKLK----EQFEKNTKSDLLLKELYV----ENAHLVRALQATEEKQRGAEKQ 1357
EM L+E+ +++ ++ E+ T+++ L ++ + E L+ L T+++ A +Q
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 1358 SRLLEEKVR 1366
L + ++
Sbjct: 948 LERLRQDMK 956
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/317 (23%), Positives = 133/317 (41%), Gaps = 48/317 (15%)
Query: 1076 VDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEM 1135
+ L+ LE L + T L L + +++ E E A R+ +E+L+ + +
Sbjct: 268 IQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHE 327
Query: 1136 EVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH---------------------- 1173
L+R Q K L Q+ + Q+ E + AQ H
Sbjct: 328 ASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKA 387
Query: 1174 -----------RVTIQMLTQSL---EEVVRSGQQQSDQIQK----LRVELECLNQEHQSL 1215
R +Q L Q L +E V QQQ DQ ++ LR L+ L E +L
Sbjct: 388 LTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTL 447
Query: 1216 QLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQD--RVAELHRLLSLQGEQA 1273
+ T L+ D + L++A+ + Q++ ++ Q+ R+ ++ L LQG+ A
Sbjct: 448 ----AGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA 503
Query: 1274 RRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFE-KNTKSDLLLKE 1332
+ + + Q+EE ++ ER++E M L+ + ++ L+E E + + +LL +E
Sbjct: 504 QGQKEEQQEELHLAVR-ERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562
Query: 1333 LYVENAHLVRALQATEE 1349
A L RA Q+ E
Sbjct: 563 QTEVTAALARAEQSIAE 579
Score = 50.1 bits (118), Expect = 1e-05
Identities = 66/358 (18%), Positives = 144/358 (40%), Gaps = 24/358 (6%)
Query: 1036 QEQLAAPEEGETKIALEREKDDMETKLLH--LEDVVRALEKHVDLRENDRLEFHRLSEEN 1093
++QLA +E + + ++ + E K L L+ + + + + E LS+E
Sbjct: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465
Query: 1094 TLLKNDLGRVRQELE---------------------AAESTHDAQRKEIEVLKKDKEKAC 1132
LL+ +RQ+LE +A+ + Q++E+ + +++E+
Sbjct: 466 ELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQ 525
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ 1192
+ L + +L L + E + + E + QS+ E+ S
Sbjct: 526 EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQA-QAQHLQEV 1251
++ LR L+ +++L L L Q L + +++ Q R+ A QA++ +V
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 1252 RLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQE 1311
L ++ E + E ++ + E + L+ +E EE + L +
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 1312 KVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALN 1369
+L++ ++ + + +L E LVR A E + + E+ + L E+++ L+
Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
Score = 42.0 bits (97), Expect = 0.004
Identities = 97/375 (25%), Positives = 163/375 (43%), Gaps = 54/375 (14%)
Query: 973 ERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARR-GSLPSHLQLADP 1031
+ LQ + EE+ + Q+Q +E QA + L K+S E +R +L LQ
Sbjct: 14 QSLQLVLEEQVLA----LQQQMAENQAASWRKL-----KNSQEAQQRQATLVRKLQAKVL 64
Query: 1032 Q-GSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLS 1090
Q SW ++L E +R ++ E +L++++ LE+ E R E L+
Sbjct: 65 QYRSWCQELEKRLEATGGPIPQRWENVEEP---NLDELLVRLEE-----EQQRCE--SLA 114
Query: 1091 EENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQN----YK 1146
E NT L R +E A+ + A R+++E L D +A E+ Q Q +K
Sbjct: 115 EVNTQL-------RLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFK 167
Query: 1147 DQLSQLNVRVLQLGQEASTHQAQNEEHR-VTIQMLTQSLEEVVRSGQQQSDQIQKLRVEL 1205
L + R+L L +E T + E + T + L + E VR +L V
Sbjct: 168 GYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGA 227
Query: 1206 ECLNQEHQSLQLPWSELTQTL---EESQDQVQGAHLR---LRQAQAQ-HLQEVRLVPQDR 1258
+ + + S ++ E Q L ++Q+ + AH R L Q ++Q L++ L QDR
Sbjct: 228 QS-REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAEL--QDR 284
Query: 1259 VAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKE 1318
V EL LL+ + Q E++EK +KA E VE E N L++ + +
Sbjct: 285 VTELSALLT--------QSQKQNEDYEKMIKALRETVEILE---TNHTELMEHEASLSRN 333
Query: 1319 QFEKNTKSDLLLKEL 1333
E+ ++K++
Sbjct: 334 AQEEKLSLQQVIKDI 348
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 107 bits (267), Expect = 8e-23
Identities = 256/1155 (22%), Positives = 456/1155 (39%), Gaps = 139/1155 (12%)
Query: 310 RLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDE---KVNLLELTWALDNE 366
RLF+ + D+VL QE +Q +E+ Q V E +V LE A E
Sbjct: 861 RLFTKVKPLLQVTRQDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERARLAE 919
Query: 367 LMTVDSAVQQAA------LACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE 420
+ ++ + A LA QEL ++E E ++ + ++ +KR + ++E
Sbjct: 920 QLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 979
Query: 421 MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWE----------QAHRQRA 470
++ + LE E+G R++L L + EA+ + F E + ++R
Sbjct: 980 LE---AHLE---------AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERK 1027
Query: 471 ALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLK 530
LE + ++ A EK+ K + + I ++ ++L E+ +L+K LK
Sbjct: 1028 LLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK-----LK 1082
Query: 531 DKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE------GLWARLPKNRH 584
+L+ +S+EL QE+ + EL+ + L + +ELQA L G A+L K+
Sbjct: 1083 RRLDGESSEL--QEQMVEQQQRAEELRAQ-LGRKEEELQAALARAEDEGGARAQLLKSLR 1139
Query: 585 SPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYE 644
+ + L A + E E + ++++ Q E + + E
Sbjct: 1140 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR-SKRE 1198
Query: 645 REIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGP 704
+E+ LK+ E+E + E A ++EL ++ + + L EQL+ RG
Sbjct: 1199 QEVTELKKTLEEETRIHEAA--------------VQELRQRHGQALGELAEQLEQARRGK 1244
Query: 705 ---EPEQMGLAPCCTQALCGLALRHHSHL--QQIRREAEAELSGELSGLGALPARRDLTL 759
E ++ L ++ L+ + +Q RR E +L G R
Sbjct: 1245 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAA 1304
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQM--CVSLALEEEELELARGKRV 817
E + Q L S + E + ++L S AQ+ L EE +LA G RV
Sbjct: 1305 EKLQRAQAELENVSGALNEAE-SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV 1363
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEA----A 873
++EAE L + + +E L + A L+ R+ EEA A
Sbjct: 1364 --RAMEAEAAGLREQLEEEAAARERAGREL-------QTAQAQLSEWRRRQEEEAGALEA 1414
Query: 874 GAGPRRRQAQDTEA-TQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAG 932
G RRR A++ EA TQ A ER R +D + E + S
Sbjct: 1415 GEEARRRAAREAEALTQRLAEKTETVDR--LERGRRRLQQELDDATMDLEQQRQLVST-- 1470
Query: 933 LEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQE 992
LE+ + LL E+ A + R A G+ +A+ RA + +E
Sbjct: 1471 LEKKQRKFDQLLAEEKAAV-----LRAVEERERAEAEGREREARALSLTRALEEEQEARE 1525
Query: 993 QASEQQARAEGALEP--------GCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEE 1044
+ Q LE G H +E A R + + L +++L A E+
Sbjct: 1526 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1585
Query: 1045 GETKI-----ALEREKD-DMETKLLHLEDVVRALEKHVDLRENDRLEFH----------- 1087
+ ++ AL+ + + D++ + E+ R L K + E +R E
Sbjct: 1586 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1645
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
+L E LK + Q E A + +++ L ++ E+ + E + QN+ +
Sbjct: 1646 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1705
Query: 1148 QLSQLNVRVLQLGQEAST-----HQAQNEEHRVTIQMLTQSLEE--VVRSGQQQSDQIQK 1200
+L L VL+L +E + QAQ + + ++ +L + ++ +Q ++ +
Sbjct: 1706 RLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1765
Query: 1201 LRVEL-------ECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEV-- 1251
L EL E LN ++ L L LT L + A +Q + Q +QE+
Sbjct: 1766 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ-IQELRG 1824
Query: 1252 RLVPQDRVAEL-HRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQ 1310
RL +D A H++ E + + Q E+ ++ + + V AE LK + + ++
Sbjct: 1825 RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1884
Query: 1311 EK---VDKLKEQFEK-NTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVR 1366
E+ D+L++Q EK N + L ++L RA QR E + E R
Sbjct: 1885 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1944
Query: 1367 ALNKLVSRIAPAALS 1381
+ L +R+ L+
Sbjct: 1945 EVTTLRNRLRRGPLT 1959
Score = 80.5 bits (197), Expect = 1e-14
Identities = 195/933 (20%), Positives = 370/933 (39%), Gaps = 128/933 (13%)
Query: 519 LKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWAR 578
LKL+ + L K++P ++ Q+E A +E + K ++LQ ++ EL+G A+
Sbjct: 852 LKLRHWQWWRLFTKVKPL-LQVTRQDEVLQARAQELQ-KVQELQQQSAREVGELQGRVAQ 909
Query: 579 LPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHY---QDLRTQ 635
L + R + + R L G A E EL++ +++ ++ Q
Sbjct: 910 LEEERARLA----EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQ 965
Query: 636 LETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQE 695
++T+ ++ I L+ + E E E AR++ L+ +K E +K +E + L++
Sbjct: 966 MQTEKKRLQQHIQELEAHLEAE----EGARQK----LQLEKVTTEAKMKKFEEDLLLLED 1017
Query: 696 QLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARR 755
Q ++ + + LA +QA L ++R + EA ++ L R
Sbjct: 1018 QNSKLSKERKLLEDRLAEFSSQA--AEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1075
Query: 756 DLTLELEEPPQGPLPRGSQRSEQL--ELERALKLQPCASEKRAQMCVSLALEEEE----L 809
ELE+ + S+ EQ+ + +RA +L+ K ++ +LA E+E
Sbjct: 1076 Q---ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARA 1132
Query: 810 ELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRES 869
+L + R +L + L + + ++ R L GE A G+ ++
Sbjct: 1133 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL-------GEELEA--LRGELEDT 1183
Query: 870 EEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGAS 929
++ A R ++ E T+ E +R+ V ++ + + G
Sbjct: 1184 LDSTNAQQELRSKREQEVTELKKTL---------EEETRIHEAAVQ-ELRQRHGQALGEL 1233
Query: 930 AAGLEQP----GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAER-----LQAIQE 980
A LEQ GA E L E + S+ + + L+ A Q R LQ +Q
Sbjct: 1234 AEQLEQARRGKGAWEKTRLALEAEVSELRAEL--SSLQTARQEGEQRRRRLELQLQEVQG 1291
Query: 981 -----ERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSW 1035
ERAR+ + ++A + GAL K ++ +++ S + QL D Q
Sbjct: 1292 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-TIRLSKELS-STEAQLHDAQELL 1349
Query: 1036 QEQLAAP-------------------EEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QE+ A + E A ER +++T L + R E+
Sbjct: 1350 QEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1409
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEME 1136
E R + E L L + ++ E ++E++ D E+ +
Sbjct: 1410 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1469
Query: 1137 VLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSD 1196
L ++ + + L++ VL+ +E +A+ E LT++LEE + ++
Sbjct: 1470 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1529
Query: 1197 QIQKLRVELECL---------------------NQEHQSLQLPWSELTQTLEESQDQVQG 1235
Q + LR ELE L Q L+ +EL L ++D
Sbjct: 1530 QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR 1589
Query: 1236 AHLRLRQAQAQHLQEV------------RLVPQDRVAEL----HRLLSLQGEQARRRLDA 1279
+ ++ + QH +++ +L Q R AE+ R AR++L+
Sbjct: 1590 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEG 1649
Query: 1280 QREEHEKQLKATEERVEEAEMILKNMEMLLQE---KVDKLK----EQFEKNTKSDLLLKE 1332
+ EE + Q+ + + EEA L+ M+ ++E +V++ + E F +N +S+ LK
Sbjct: 1650 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKG 1709
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKV 1365
L E L L A++ +R A++ + ++V
Sbjct: 1710 LEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1742
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 107 bits (267), Expect = 8e-23
Identities = 256/1155 (22%), Positives = 456/1155 (39%), Gaps = 139/1155 (12%)
Query: 310 RLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDE---KVNLLELTWALDNE 366
RLF+ + D+VL QE +Q +E+ Q V E +V LE A E
Sbjct: 853 RLFTKVKPLLQVTRQDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERARLAE 911
Query: 367 LMTVDSAVQQAA------LACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE 420
+ ++ + A LA QEL ++E E ++ + ++ +KR + ++E
Sbjct: 912 QLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 971
Query: 421 MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWE----------QAHRQRA 470
++ + LE E+G R++L L + EA+ + F E + ++R
Sbjct: 972 LE---AHLE---------AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERK 1019
Query: 471 ALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLK 530
LE + ++ A EK+ K + + I ++ ++L E+ +L+K LK
Sbjct: 1020 LLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK-----LK 1074
Query: 531 DKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE------GLWARLPKNRH 584
+L+ +S+EL QE+ + EL+ + L + +ELQA L G A+L K+
Sbjct: 1075 RRLDGESSEL--QEQMVEQQQRAEELRAQ-LGRKEEELQAALARAEDEGGARAQLLKSLR 1131
Query: 585 SPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYE 644
+ + L A + E E + ++++ Q E + + E
Sbjct: 1132 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR-SKRE 1190
Query: 645 REIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGP 704
+E+ LK+ E+E + E A ++EL ++ + + L EQL+ RG
Sbjct: 1191 QEVTELKKTLEEETRIHEAA--------------VQELRQRHGQALGELAEQLEQARRGK 1236
Query: 705 ---EPEQMGLAPCCTQALCGLALRHHSHL--QQIRREAEAELSGELSGLGALPARRDLTL 759
E ++ L ++ L+ + +Q RR E +L G R
Sbjct: 1237 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAA 1296
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQM--CVSLALEEEELELARGKRV 817
E + Q L S + E + ++L S AQ+ L EE +LA G RV
Sbjct: 1297 EKLQRAQAELENVSGALNEAE-SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV 1355
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEA----A 873
++EAE L + + +E L + A L+ R+ EEA A
Sbjct: 1356 --RAMEAEAAGLREQLEEEAAARERAGREL-------QTAQAQLSEWRRRQEEEAGALEA 1406
Query: 874 GAGPRRRQAQDTEA-TQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAG 932
G RRR A++ EA TQ A ER R +D + E + S
Sbjct: 1407 GEEARRRAAREAEALTQRLAEKTETVDR--LERGRRRLQQELDDATMDLEQQRQLVST-- 1462
Query: 933 LEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQE 992
LE+ + LL E+ A + R A G+ +A+ RA + +E
Sbjct: 1463 LEKKQRKFDQLLAEEKAAV-----LRAVEERERAEAEGREREARALSLTRALEEEQEARE 1517
Query: 993 QASEQQARAEGALEP--------GCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEE 1044
+ Q LE G H +E A R + + L +++L A E+
Sbjct: 1518 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1577
Query: 1045 GETKI-----ALEREKD-DMETKLLHLEDVVRALEKHVDLRENDRLEFH----------- 1087
+ ++ AL+ + + D++ + E+ R L K + E +R E
Sbjct: 1578 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1637
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
+L E LK + Q E A + +++ L ++ E+ + E + QN+ +
Sbjct: 1638 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1697
Query: 1148 QLSQLNVRVLQLGQEAST-----HQAQNEEHRVTIQMLTQSLEE--VVRSGQQQSDQIQK 1200
+L L VL+L +E + QAQ + + ++ +L + ++ +Q ++ +
Sbjct: 1698 RLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1757
Query: 1201 LRVEL-------ECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEV-- 1251
L EL E LN ++ L L LT L + A +Q + Q +QE+
Sbjct: 1758 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ-IQELRG 1816
Query: 1252 RLVPQDRVAEL-HRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQ 1310
RL +D A H++ E + + Q E+ ++ + + V AE LK + + ++
Sbjct: 1817 RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1876
Query: 1311 EK---VDKLKEQFEK-NTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVR 1366
E+ D+L++Q EK N + L ++L RA QR E + E R
Sbjct: 1877 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1936
Query: 1367 ALNKLVSRIAPAALS 1381
+ L +R+ L+
Sbjct: 1937 EVTTLRNRLRRGPLT 1951
Score = 80.5 bits (197), Expect = 1e-14
Identities = 195/933 (20%), Positives = 370/933 (39%), Gaps = 128/933 (13%)
Query: 519 LKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWAR 578
LKL+ + L K++P ++ Q+E A +E + K ++LQ ++ EL+G A+
Sbjct: 844 LKLRHWQWWRLFTKVKPL-LQVTRQDEVLQARAQELQ-KVQELQQQSAREVGELQGRVAQ 901
Query: 579 LPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHY---QDLRTQ 635
L + R + + R L G A E EL++ +++ ++ Q
Sbjct: 902 LEEERARLA----EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQ 957
Query: 636 LETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQE 695
++T+ ++ I L+ + E E E AR++ L+ +K E +K +E + L++
Sbjct: 958 MQTEKKRLQQHIQELEAHLEAE----EGARQK----LQLEKVTTEAKMKKFEEDLLLLED 1009
Query: 696 QLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARR 755
Q ++ + + LA +QA L ++R + EA ++ L R
Sbjct: 1010 QNSKLSKERKLLEDRLAEFSSQA--AEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1067
Query: 756 DLTLELEEPPQGPLPRGSQRSEQL--ELERALKLQPCASEKRAQMCVSLALEEEE----L 809
ELE+ + S+ EQ+ + +RA +L+ K ++ +LA E+E
Sbjct: 1068 Q---ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARA 1124
Query: 810 ELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRES 869
+L + R +L + L + + ++ R L GE A G+ ++
Sbjct: 1125 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL-------GEELEA--LRGELEDT 1175
Query: 870 EEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGAS 929
++ A R ++ E T+ E +R+ V ++ + + G
Sbjct: 1176 LDSTNAQQELRSKREQEVTELKKTL---------EEETRIHEAAVQ-ELRQRHGQALGEL 1225
Query: 930 AAGLEQP----GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAER-----LQAIQE 980
A LEQ GA E L E + S+ + + L+ A Q R LQ +Q
Sbjct: 1226 AEQLEQARRGKGAWEKTRLALEAEVSELRAEL--SSLQTARQEGEQRRRRLELQLQEVQG 1283
Query: 981 -----ERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSW 1035
ERAR+ + ++A + GAL K ++ +++ S + QL D Q
Sbjct: 1284 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-TIRLSKELS-STEAQLHDAQELL 1341
Query: 1036 QEQLAAP-------------------EEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QE+ A + E A ER +++T L + R E+
Sbjct: 1342 QEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1401
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEME 1136
E R + E L L + ++ E ++E++ D E+ +
Sbjct: 1402 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1461
Query: 1137 VLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSD 1196
L ++ + + L++ VL+ +E +A+ E LT++LEE + ++
Sbjct: 1462 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1521
Query: 1197 QIQKLRVELECL---------------------NQEHQSLQLPWSELTQTLEESQDQVQG 1235
Q + LR ELE L Q L+ +EL L ++D
Sbjct: 1522 QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR 1581
Query: 1236 AHLRLRQAQAQHLQEV------------RLVPQDRVAEL----HRLLSLQGEQARRRLDA 1279
+ ++ + QH +++ +L Q R AE+ R AR++L+
Sbjct: 1582 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEG 1641
Query: 1280 QREEHEKQLKATEERVEEAEMILKNMEMLLQE---KVDKLK----EQFEKNTKSDLLLKE 1332
+ EE + Q+ + + EEA L+ M+ ++E +V++ + E F +N +S+ LK
Sbjct: 1642 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKG 1701
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKV 1365
L E L L A++ +R A++ + ++V
Sbjct: 1702 LEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1734
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 107 bits (267), Expect = 8e-23
Identities = 256/1155 (22%), Positives = 456/1155 (39%), Gaps = 139/1155 (12%)
Query: 310 RLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDE---KVNLLELTWALDNE 366
RLF+ + D+VL QE +Q +E+ Q V E +V LE A E
Sbjct: 894 RLFTKVKPLLQVTRQDEVLQARAQE-LQKVQELQQQSAREVGELQGRVAQLEEERARLAE 952
Query: 367 LMTVDSAVQQAA------LACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE 420
+ ++ + A LA QEL ++E E ++ + ++ +KR + ++E
Sbjct: 953 QLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQE 1012
Query: 421 MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWE----------QAHRQRA 470
++ + LE E+G R++L L + EA+ + F E + ++R
Sbjct: 1013 LE---AHLE---------AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERK 1060
Query: 471 ALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLK 530
LE + ++ A EK+ K + + I ++ ++L E+ +L+K LK
Sbjct: 1061 LLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK-----LK 1115
Query: 531 DKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELE------GLWARLPKNRH 584
+L+ +S+EL QE+ + EL+ + L + +ELQA L G A+L K+
Sbjct: 1116 RRLDGESSEL--QEQMVEQQQRAEELRAQ-LGRKEEELQAALARAEDEGGARAQLLKSLR 1172
Query: 585 SPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYE 644
+ + L A + E E + ++++ Q E + + E
Sbjct: 1173 EAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR-SKRE 1231
Query: 645 REIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGP 704
+E+ LK+ E+E + E A ++EL ++ + + L EQL+ RG
Sbjct: 1232 QEVTELKKTLEEETRIHEAA--------------VQELRQRHGQALGELAEQLEQARRGK 1277
Query: 705 ---EPEQMGLAPCCTQALCGLALRHHSHL--QQIRREAEAELSGELSGLGALPARRDLTL 759
E ++ L ++ L+ + +Q RR E +L G R
Sbjct: 1278 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAA 1337
Query: 760 ELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQM--CVSLALEEEELELARGKRV 817
E + Q L S + E + ++L S AQ+ L EE +LA G RV
Sbjct: 1338 EKLQRAQAELENVSGALNEAE-SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRV 1396
Query: 818 DGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEA----A 873
++EAE L + + +E L + A L+ R+ EEA A
Sbjct: 1397 --RAMEAEAAGLREQLEEEAAARERAGREL-------QTAQAQLSEWRRRQEEEAGALEA 1447
Query: 874 GAGPRRRQAQDTEA-TQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAG 932
G RRR A++ EA TQ A ER R +D + E + S
Sbjct: 1448 GEEARRRAAREAEALTQRLAEKTETVDR--LERGRRRLQQELDDATMDLEQQRQLVST-- 1503
Query: 933 LEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQE 992
LE+ + LL E+ A + R A G+ +A+ RA + +E
Sbjct: 1504 LEKKQRKFDQLLAEEKAAV-----LRAVEERERAEAEGREREARALSLTRALEEEQEARE 1558
Query: 993 QASEQQARAEGALEP--------GCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEE 1044
+ Q LE G H +E A R + + L +++L A E+
Sbjct: 1559 ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAED 1618
Query: 1045 GETKI-----ALEREKD-DMETKLLHLEDVVRALEKHVDLRENDRLEFH----------- 1087
+ ++ AL+ + + D++ + E+ R L K + E +R E
Sbjct: 1619 AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARK 1678
Query: 1088 RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKD 1147
+L E LK + Q E A + +++ L ++ E+ + E + QN+ +
Sbjct: 1679 KLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEK 1738
Query: 1148 QLSQLNVRVLQLGQEAST-----HQAQNEEHRVTIQMLTQSLEE--VVRSGQQQSDQIQK 1200
+L L VL+L +E + QAQ + + ++ +L + ++ +Q ++ +
Sbjct: 1739 RLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQ 1798
Query: 1201 LRVEL-------ECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEV-- 1251
L EL E LN ++ L L LT L + A +Q + Q +QE+
Sbjct: 1799 LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQ-IQELRG 1857
Query: 1252 RLVPQDRVAEL-HRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQ 1310
RL +D A H++ E + + Q E+ ++ + + V AE LK + + ++
Sbjct: 1858 RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1917
Query: 1311 EK---VDKLKEQFEK-NTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVR 1366
E+ D+L++Q EK N + L ++L RA QR E + E R
Sbjct: 1918 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNR 1977
Query: 1367 ALNKLVSRIAPAALS 1381
+ L +R+ L+
Sbjct: 1978 EVTTLRNRLRRGPLT 1992
Score = 80.5 bits (197), Expect = 1e-14
Identities = 195/933 (20%), Positives = 370/933 (39%), Gaps = 128/933 (13%)
Query: 519 LKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWAR 578
LKL+ + L K++P ++ Q+E A +E + K ++LQ ++ EL+G A+
Sbjct: 885 LKLRHWQWWRLFTKVKPL-LQVTRQDEVLQARAQELQ-KVQELQQQSAREVGELQGRVAQ 942
Query: 579 LPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHY---QDLRTQ 635
L + R + + R L G A E EL++ +++ ++ Q
Sbjct: 943 LEEERARLA----EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQ 998
Query: 636 LETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQE 695
++T+ ++ I L+ + E E E AR++ L+ +K E +K +E + L++
Sbjct: 999 MQTEKKRLQQHIQELEAHLEAE----EGARQK----LQLEKVTTEAKMKKFEEDLLLLED 1050
Query: 696 QLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARR 755
Q ++ + + LA +QA L ++R + EA ++ L R
Sbjct: 1051 QNSKLSKERKLLEDRLAEFSSQA--AEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1108
Query: 756 DLTLELEEPPQGPLPRGSQRSEQL--ELERALKLQPCASEKRAQMCVSLALEEEE----L 809
ELE+ + S+ EQ+ + +RA +L+ K ++ +LA E+E
Sbjct: 1109 Q---ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARA 1165
Query: 810 ELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRES 869
+L + R +L + L + + ++ R L GE A G+ ++
Sbjct: 1166 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL-------GEELEA--LRGELEDT 1216
Query: 870 EEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGAS 929
++ A R ++ E T+ E +R+ V ++ + + G
Sbjct: 1217 LDSTNAQQELRSKREQEVTELKKTL---------EEETRIHEAAVQ-ELRQRHGQALGEL 1266
Query: 930 AAGLEQP----GARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAER-----LQAIQE 980
A LEQ GA E L E + S+ + + L+ A Q R LQ +Q
Sbjct: 1267 AEQLEQARRGKGAWEKTRLALEAEVSELRAEL--SSLQTARQEGEQRRRRLELQLQEVQG 1324
Query: 981 -----ERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSW 1035
ERAR+ + ++A + GAL K ++ +++ S + QL D Q
Sbjct: 1325 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-TIRLSKELS-STEAQLHDAQELL 1382
Query: 1036 QEQLAAP-------------------EEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QE+ A + E A ER +++T L + R E+
Sbjct: 1383 QEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEA 1442
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEME 1136
E R + E L L + ++ E ++E++ D E+ +
Sbjct: 1443 GALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS 1502
Query: 1137 VLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSD 1196
L ++ + + L++ VL+ +E +A+ E LT++LEE + ++
Sbjct: 1503 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1562
Query: 1197 QIQKLRVELECL---------------------NQEHQSLQLPWSELTQTLEESQDQVQG 1235
Q + LR ELE L Q L+ +EL L ++D
Sbjct: 1563 QNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR 1622
Query: 1236 AHLRLRQAQAQHLQEV------------RLVPQDRVAEL----HRLLSLQGEQARRRLDA 1279
+ ++ + QH +++ +L Q R AE+ R AR++L+
Sbjct: 1623 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEG 1682
Query: 1280 QREEHEKQLKATEERVEEAEMILKNMEMLLQE---KVDKLK----EQFEKNTKSDLLLKE 1332
+ EE + Q+ + + EEA L+ M+ ++E +V++ + E F +N +S+ LK
Sbjct: 1683 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKG 1742
Query: 1333 LYVENAHLVRALQATEEKQRGAEKQSRLLEEKV 1365
L E L L A++ +R A++ + ++V
Sbjct: 1743 LEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1775
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 104 bits (260), Expect = 5e-22
Identities = 226/915 (24%), Positives = 365/915 (39%), Gaps = 158/915 (17%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKK---IKHLE 440
QE Q E+L R+RD+ ++ E A + +E++ H LEQL K+ K L
Sbjct: 624 QEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELV 683
Query: 441 QGYRERLS---LLRSEVEAERELFWE---QAHRQRAALEWDVGRLQAEEAGLREKLTLAL 494
+ RE LS L R ++AE+ E +A R LE + +L+AEEA L++ L+
Sbjct: 684 E-VREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLS 742
Query: 495 KENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEY 554
N L ++ + D RL +L+ ++K Q + A++E A
Sbjct: 743 ALNESLAQDKL-------DLNRLVAQLE-------EEKSALQGRQRQAEQEATVA----- 783
Query: 555 ELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPV 614
R+ Q+R +EL+ E E R+ L G S V
Sbjct: 784 ----REEQERLEELRLEQE------------------VARQGLEG-----------SLRV 810
Query: 615 SIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARR---REVSV 671
+ + + +EQ + R+QL + ++A L R +++EQARR R+V
Sbjct: 811 AEQAQEALEQQLPTLRHERSQL-------QEQLAQLSRQLSGREQELEQARREAQRQVEA 863
Query: 672 LEGQKADLEELHEKSQEVIWGLQEQLQDTAR-----GPEPEQMGLAPCCTQALCGLALRH 726
LE + E L ++ GL QL R E ++ L + R
Sbjct: 864 LERAAREKEALAKEHA----GLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 919
Query: 727 HSHLQQIRREAEAE----------LSGELSGLG----ALPARRDLTLEL--------EEP 764
+ L+ R + EAE L+GEL+GL A + L EL E
Sbjct: 920 LAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 765 PQGPLPRGSQRSEQLELERALKLQPCA----SEKRAQMCVSLALEEEELELARGKRVDGP 820
Q L R + + + +L+R + + A +RAQ+ L E+EEL LAR
Sbjct: 980 AQASL-REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL-LAR------- 1030
Query: 821 SLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRR 880
LEAE + L ++ +A QE GLL L ++ L+ SE+ G R
Sbjct: 1031 -LEAEKEELSEE--IAALQQERDEGLL-LAESEKQQALSLKESEKTALSEKLMGT----R 1082
Query: 881 QAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLE--QPGA 938
+ T + + S +R + D+ + E A A + Q A
Sbjct: 1083 HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA 1142
Query: 939 RELPLLGTERDASQTQPRMWEPPLRPAASCRG--QAERLQAIQEERARSWSRGTQEQASE 996
R+ LG +RD+ + LR R + E L+A ++ R R Q Q +
Sbjct: 1143 RD---LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199
Query: 997 QQARA--EGALEPGCHKHSVEVAR---RGSLPSHLQLADPQGSWQEQLAAPEEGETKIAL 1051
+ R+ EGA E + S E R + + + L +++LA EE T A+
Sbjct: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEART--AV 1257
Query: 1052 EREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE 1111
+E ++ T L +E LE +L+E R + L ENT L +L ++ L E
Sbjct: 1258 GKEAGELRTGLQEVER--SRLEARRELQEL-RRQMKMLDSENTRLGRELAELQGRLALGE 1314
Query: 1112 STHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNE 1171
R+E L++ K + +EV+ ++ Q + +L Q Q
Sbjct: 1315 RAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL-----------------QEQEG 1357
Query: 1172 EHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQD 1231
E R + L SLEE + +QQ D + L ++LE E L L S + +
Sbjct: 1358 EFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEA 1417
Query: 1232 QVQGAHLRLRQAQAQ 1246
++ ++ R A+AQ
Sbjct: 1418 ELARVEVQRRAAEAQ 1432
Score = 103 bits (257), Expect = 1e-21
Identities = 248/1113 (22%), Positives = 437/1113 (39%), Gaps = 170/1113 (15%)
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
+V++ + + R+ LE AE + L KE L L ++ I E+ ++ + +
Sbjct: 915 EVQRQLAQLEARREQLE-AEGQALLLAKET--LTGELAGLRQQIIATQEKASLDKELMAQ 971
Query: 452 SEVEAERELFWEQAHRQRAALEWDVGRLQAE-EAGLREKLTLALKENSRLQKEIVEVVEK 510
V+AERE QRAA E D+ RLQ E EA RE + S+LQ+E E++ +
Sbjct: 972 KLVQAEREA-QASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 511 LSD-----SERLALKLQKDLEFVLKDKLEPQSAELLAQEER-------------FAAVLK 552
L SE +A Q+ E +L + E Q A L + E+ A +
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
Query: 553 EYELKCRDLQDRNDE-------LQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGI 605
E E + RD Q R ++ L +EL L A+ + + + + Q LG
Sbjct: 1091 EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRD 1150
Query: 606 SFLGNSAPVSIETELMME-------QVKEHYQDLRTQLETKVNYYEREIAALKRNFEKER 658
S L + + + L+ + ++ E + LR E + +E L+R+ +
Sbjct: 1151 SCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGR-EVQRQEAGELRRSLGEGA 1209
Query: 659 KDMEQARRRE------VSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLA 712
K+ E RR V E ++ L+ +E ++ + L+E TA G E ++
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR--TAVGKEAGELRTG 1267
Query: 713 PCCTQALCGLALRHHSHLQQIRREAE-------------AELSGELS-GLGALPARRDLT 758
Q + L LQ++RR+ + AEL G L+ G A R T
Sbjct: 1268 ---LQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324
Query: 759 LELEEPP-QGPLPRGSQRSEQLELERALKLQPCASEKRAQMCV-----SLALEEEELELA 812
L L + +G R E +R L+ Q R + + + E+++L+ A
Sbjct: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA 1384
Query: 813 RGKRVD---------------------GPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRP 851
RG + LEAE+ + A + G R L
Sbjct: 1385 RGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGL 1444
Query: 852 GCGERPLAWLAPGDGRESEEAAGAG-------PRRRQAQDTEATQSPAPAPAPASHGPSE 904
G G P P G + +A G P + SP PA +PAS
Sbjct: 1445 GLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPD--- 1501
Query: 905 RWSRMQPCGVDGDI---------VPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQP 955
+ P V G + +E + + L R+L + ERD++ ++
Sbjct: 1502 ----LDPEAVRGALREFLQELRSAQRERDELRTQTSALN----RQLAEMEAERDSATSRA 1553
Query: 956 RMWEPPLRPAASCRGQAE-RLQAIQEERA---RSWSRGTQEQAS--EQQARAEGALEPGC 1009
R + + + R + RL +Q E A S R +E+ + +Q A E +L+
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
Query: 1010 HKHSVEVARRGSLPSH-LQLADPQGSWQEQLAAPEEGETKIALEREK------------D 1056
+ + + ++ +L + +E L A E K+ L+R
Sbjct: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
Query: 1057 DMETKLLHLEDVVRALEKHVDLREND----RLEFHRLS-------EENTLLKNDLGRVRQ 1105
D E + L+D V +L++ V E +L RL+ E L++ + + +
Sbjct: 1674 DREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 1106 ELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEAST 1165
L + ++ ++ R + L+K + +VL + + LS+ + LG++ T
Sbjct: 1734 ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQT 1793
Query: 1166 HQ---AQNEEHRVTIQMLTQSLEEVVRSGQQQS----DQIQKLRVELECLNQEHQSLQLP 1218
+ A E RV + Q L EV+R Q+ + +QKL+ E L + SLQ
Sbjct: 1794 LRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853
Query: 1219 WSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLD 1278
++ LE + +V+ + LRL + + + + V ++++ + L E+ RLD
Sbjct: 1854 LAQ----LEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKG--RLD 1907
Query: 1279 AQREEHEKQLKATEERVEEAE---MILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYV 1335
E +L + ++++ E ++L+ Q +VD ++Q E + ++ L
Sbjct: 1908 RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQE----VERLRS 1963
Query: 1336 ENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
A R L+A E R ++ R LEE+V L
Sbjct: 1964 AQAQTERTLEARERAHR---QRVRGLEEQVSTL 1993
Score = 80.5 bits (197), Expect = 1e-14
Identities = 234/1049 (22%), Positives = 414/1049 (39%), Gaps = 154/1049 (14%)
Query: 396 LARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEK--KIKHLEQGY---RERLSLL 450
L E +Q+L R E + E D+ ++E+ + LE G +E L+
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
Query: 451 RSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEK 510
R VE R+L EQA +R +LQA + G + + L RLQ +I++ ++
Sbjct: 139 RQSVELRRQLQEEQASYRR--------KLQAYQEGQQRQAQLV----QRLQGKILQYKKR 186
Query: 511 LSDSERLALKLQKDLEFV-LKDKLEPQSAEL----LAQEERFAAVLKEYELKCRDLQDR- 564
S+ E+ L+ +LE L+D Q E L +E++ +A L + R+ D+
Sbjct: 187 CSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQA 246
Query: 565 ---NDELQAELEGL---WARLPKN--RHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSI 616
N L ++ + W R K +W RR+ +A S
Sbjct: 247 GSANQALSEDIRKVTNDWTRCRKELEHREAAW-----RREEESF----------NAYFSN 291
Query: 617 ETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQK 676
E ++ ++ R E K+ + ER++ L + + +++A + L +
Sbjct: 292 EHSRLLLLWRQVVGFRRLVSEVKM-FTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE 350
Query: 677 ADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRRE 736
+ E EK + L+EQL+D + LA QQ++ +
Sbjct: 351 SRAEAALEKQALLQAQLEEQLRDKVL----REKDLAQ-----------------QQMQSD 389
Query: 737 AE-AELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKR 795
+ A+LS ++ LG L +R LE+ +E+LE +L+LQ A+ +
Sbjct: 390 LDKADLSARVTELG-LAVKRLEKQNLEKDQVN-----KDLTEKLEALESLRLQEQAALET 443
Query: 796 AQMCVSLALEEEELELARGKRVDGPS----LEAEMQALPKDGLVAG-SGQEGTRGLLPLR 850
L++ +LA+ D S +E A +G + G SGQ
Sbjct: 444 ED---GEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSS 500
Query: 851 PGCGERPLAWLAPGDGRESEEA---AGAGPRRRQAQDT----EATQSP-APAPAPASHGP 902
PG G P +P S A + R+ Q QD EA+Q S
Sbjct: 501 PGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE 560
Query: 903 SERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPL 962
SER + ++ + + GA A + RE+ L + + + L
Sbjct: 561 SERRA------LEEQLQRLRDKTDGAMQA--HEDAQREVQRLRSANELLSREKSNLAHSL 612
Query: 963 R----PAASCRGQAERLQAIQEE--RARSWSRGTQEQASEQQARAEGALEPGCHKHSVEV 1016
+ A R + E+LQA QEE R R QE A + AR LE +
Sbjct: 613 QVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLE 672
Query: 1017 ARRGSLPSHL---QLADPQGSWQEQLAAPEEGET----------KIALEREKDDMETKLL 1063
+R L L + A + + Q + E+ E ++ LE + +
Sbjct: 673 GKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA 732
Query: 1064 HLEDVVRALEKHVDLRENDRLEFHR----LSEENTLLKNDLGRVRQELEAAESTHDAQRK 1119
L+D + L + D+L+ +R L EE + L+ GR RQ + A + Q +
Sbjct: 733 SLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ---GRQRQAEQEATVAREEQER 789
Query: 1120 EIEVLKKDKEKACSEM-----------EVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQA 1168
+E L+ ++E A + E L +Q + + SQL ++ QL ++ S +
Sbjct: 790 -LEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ 848
Query: 1169 QNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEE 1228
+ E+ R Q ++LE R + + + L V+L +E ++L SE L
Sbjct: 849 ELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL----SEEATRLRL 904
Query: 1229 SQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQA--RRRLDAQREEH-- 1284
++ ++G+ +++ AQ + + A L +L GE A R+++ A +E+
Sbjct: 905 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASL 964
Query: 1285 EKQLKATE--ERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVR 1342
+K+L A + + EA+ L+ +E + +L+ + + +EL E A L
Sbjct: 965 DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQRE------KEAAWRELEAERAQLQS 1018
Query: 1343 ALQATEEKQRG-AEKQSRLLEEKVRALNK 1370
LQ +E+ E + L E++ AL +
Sbjct: 1019 QLQREQEELLARLEAEKEELSEEIAALQQ 1047
Score = 64.3 bits (155), Expect = 8e-10
Identities = 122/573 (21%), Positives = 233/573 (40%), Gaps = 63/573 (10%)
Query: 212 SSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEF--QLGLFSHEPAL 269
S+ L +E + + S+ + + EEL KL + + EE Q E
Sbjct: 596 SANELLSREKSNLAHSLQVAQQQAEELRQEREKL------QAAQEELRRQRDRLEEEQED 649
Query: 270 LLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLA 329
++ RV+ SH Q+ + G + LV + +L + D + A
Sbjct: 650 AVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 330 MWTQEGIQNGREI----LQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQE 385
+ E + E+ L++ + S+ + ++ L NE + D +A +E
Sbjct: 710 LTKAEAGRVELELSMTKLRAEEASLQDSLSKLSAL----NESLAQDKLDLNRLVAQLEEE 765
Query: 386 LSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRE 445
S QG+ Q +E AR++ ER E+ LE +L ++ E+ + LEQ
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL-RVAEQAQEALEQ---- 820
Query: 446 RLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIV 505
+L LR E +E Q RQ + E ++ + + E E L A +E L KE
Sbjct: 821 QLPTLRHERSQLQEQL-AQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879
Query: 506 EVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRN 565
+ +L +ER L + ++ L ++E L E + + L+ R
Sbjct: 880 GLAVQLVAAEREGRTLSE------------EATRLRLEKEALEGSLFEVQRQLAQLEARR 927
Query: 566 DELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQV 625
++L+AE + L + + + G R+Q+ + S++ ELM +++
Sbjct: 928 EQLEAEGQALLLA----KETLTGELAGLRQQI----------IATQEKASLDKELMAQKL 973
Query: 626 KEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQK----ADLEE 681
+ ++ + L + +E ++ L+R E +++E R + S L+ ++ A LE
Sbjct: 974 VQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEA 1033
Query: 682 LHEKSQEVIWGLQEQLQD---TARGPEPEQMGLAPCCTQALCG--LALRH-----HSHLQ 731
E+ E I LQ++ + A + + + L AL + RH ++
Sbjct: 1034 EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEME 1093
Query: 732 QIRREAEAELSGELSGLGALPAR-RDLTLELEE 763
+ +R+A++ + S + AL + RDL + EE
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126
Score = 59.7 bits (143), Expect = 2e-08
Identities = 77/357 (21%), Positives = 152/357 (42%), Gaps = 34/357 (9%)
Query: 1049 IALEREKDDMETKLLHLEDVV---RALEKHVDLREN---DRLEFH-RLSEENTLLKNDLG 1101
++L+ E ++ +L +ED++ RA + ++ N +RLE RL + G
Sbjct: 77 LSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRG 136
Query: 1102 RVRQELEAAESTHDAQ---RKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQ 1158
VRQ +E + Q R++++ ++ +++ ++ L + YK + S+L ++L+
Sbjct: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
Query: 1159 LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELE-------CLNQE 1211
E + ++ EH ++ LEE + + LR +L+ L+++
Sbjct: 197 RSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSED 256
Query: 1212 HQSLQLPWSELTQTLEESQDQ-----------VQGAHLRLRQAQAQHLQEVRLVPQDRVA 1260
+ + W+ + LE + H RL Q + RLV + ++
Sbjct: 257 IRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF 316
Query: 1261 ELHRLLSLQGEQARRRLDAQREEH--EKQLKATEERVEEA----EMILKNMEMLLQEKVD 1314
LL L GE AR Q L+ E R E A ++ +E L++KV
Sbjct: 317 TERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVL 376
Query: 1315 KLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKL 1371
+ K+ ++ +SDL +L L A++ E++ ++ ++ L EK+ AL L
Sbjct: 377 REKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESL 433
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 103 bits (256), Expect = 1e-21
Identities = 257/1100 (23%), Positives = 420/1100 (38%), Gaps = 248/1100 (22%)
Query: 375 QQAALACYHQ------ELSYQQGQVEQLARERDKARQD----LERAEKRNLEFVKEMDDC 424
+QA+ HQ L ++ Q++++A +++ RQD L A + ++E D
Sbjct: 543 EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAA 602
Query: 425 HSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEA 484
LE L ++K LE ++ + +E + QA R++A L V LQA
Sbjct: 603 LKQLEALEKEKAAKLE--ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660
Query: 485 GLREKLTLALKENSRLQKEIVEVVEKLSDSERLALK---LQKDLEFVLKDKLEPQSAELL 541
R++ A + + L+ ++ +K ++ ER+A + LQ+ L+ LK+ L+ L
Sbjct: 661 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQ-ALKESLKVTKGSLE 719
Query: 542 AQEERFAAVLKEY-----ELKC--RDLQDRNDELQAELE-------GLWARLPKNRHSPS 587
++ R A L+E ELK R L +++ + ELE GL ARL + +
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ 779
Query: 588 WSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQV---KEHYQDLRTQLETKVNYYE 644
+ RR+L + E E ++++V +E Y+D + + ++
Sbjct: 780 AETEVLRRELA-------EAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQ 832
Query: 645 REIAALKRNFEKERKDMEQARRREVSV-------LEGQKADLEELH-------------- 683
++ LK EK R+++++A+ + + + Q+ +L ELH
Sbjct: 833 EQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE 892
Query: 684 ---EKSQEVIWGLQEQL--------------------QDTA-------------RGPE-- 705
+K + + LQE++ Q+TA R PE
Sbjct: 893 VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
Query: 706 PEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPP 765
EQ G C TQA LQ + REAE ++ EL L A +E
Sbjct: 953 EEQQGRQFCSTQAA----------LQAMEREAE-QMGNELERLRAAL--------MESQG 993
Query: 766 QGPLPRGSQRSE--QLELERALKLQPCASEKRA----QMCVSLALEEEELELARGKRVDG 819
Q RG Q E +L ER A EK A +M + AL E+ +E A +
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQ---- 1049
Query: 820 PSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRR 879
EA AL + G QE + L L +E EE R+
Sbjct: 1050 ---EALAHALTEK---EGKDQELAK-------------LRGLEAAQIKELEEL-----RQ 1085
Query: 880 RQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAR 939
Q E A S SE R +P G PK E A + LEQ +
Sbjct: 1086 TVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTG------PKL-EALRAEVSKLEQQCQK 1138
Query: 940 ELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQA 999
+ Q Q E L +AER + + A +G E+ +++
Sbjct: 1139 Q-----------QEQADSLERSL--------EAERASRAERDSALETLQGQLEEKAQELG 1179
Query: 1000 RAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDME 1059
++ AL + +LA + Q+ A +E + ++A R++ + +
Sbjct: 1180 HSQSALAS----------------AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERK 1223
Query: 1060 TKLLH-LEDVVRALEKHVDLRENDRLEFHRL----SEENTLLKNDLGRVRQELEAAESTH 1114
L+ LE+ V L + V +E + E RL SE++ L+ L R+ Q A+ S
Sbjct: 1224 NSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERL-RLLQAETASNSAR 1282
Query: 1115 DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQA---QNE 1171
A+R L+++ + E E ++N + +L+ R +LGQE Q Q E
Sbjct: 1283 AAERSS--ALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKE 1340
Query: 1172 EHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQD 1231
+ T+Q+ EH S Q SEL Q
Sbjct: 1341 QALSTLQL-------------------------------EHTSTQALVSELLPAKHLCQ- 1368
Query: 1232 QVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQ-ARRRLDAQREEHEKQLKA 1290
Q+Q + + L++ + AEL R GE R+ A++E +QL+A
Sbjct: 1369 QLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA 1428
Query: 1291 TEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLL------LKELYVENAHLVRAL 1344
+ E +LK LL E+ L E+ N L +E YV+ VRA
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGER--ANLGRQFLEVELDQAREKYVQELAAVRAD 1486
Query: 1345 QATE--EKQRGAEKQSRLLE 1362
T E QR A+ +R LE
Sbjct: 1487 AETRLAEVQREAQSTARELE 1506
Score = 92.4 bits (228), Expect = 3e-18
Identities = 261/1221 (21%), Positives = 474/1221 (38%), Gaps = 158/1221 (12%)
Query: 234 EKEELEDLFNKL-DQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEES 292
EK +++ N+L +++GD L EF L + AL + K ++ W Q E
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364
Query: 293 GCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSL-DFSVD 351
L +++ D +++L Q + E L L D
Sbjct: 365 -----------------ELSAALQDKKCLEEKNEIL----QGKLSQLEEHLSQLQDNPPQ 403
Query: 352 EKVNLLELTWALDNELMTVDSAVQQAA-LACYHQELSYQQGQVEQLARERDKARQDLERA 410
EK +L +++ +++ Q+AA LA + +L Q +VE L ER + L A
Sbjct: 404 EKGEVL-------GDVLQLETLKQEAATLAANNTQL---QARVEMLETERGQQEAKL-LA 452
Query: 411 EKRNLEFVKE-----MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEA-ERELFWEQ 464
E+ + E K+ + D S++ L++ K + LEQ + + L ++V + EL
Sbjct: 453 ERGHFEEEKQQLSSLITDLQSSISNLSQAK-EELEQASQAHGARLTAQVASLTSELTTLN 511
Query: 465 AHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKD 524
A Q+ E + QA+E + +L L++ + + + VE+LS S + + K+
Sbjct: 512 ATIQQQDQELAGLKQQAKEK--QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
Query: 525 LEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLP---K 581
+ + + + +L E A L+E + + L+ E A+LE L +L +
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 582 NRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKV- 640
R S S +R+ L E QV E LR++ +
Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689
Query: 641 --------NYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVI-- 690
+ + ++ ALK + + + +E+ +RR LE Q+ + EL +++ ++
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQ 749
Query: 691 ---------------WGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRH--HSHLQQI 733
GL+ +LQ + E L +A +A +H S +Q+
Sbjct: 750 HKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEA---MAAQHTAESECEQL 806
Query: 734 RREAEA------ELSGELSGLGALPARRDLTLELE-EPPQGPLPRGSQRSEQLELERALK 786
+E A + E + GA+ + +TL+ E E + L ++ +E L+
Sbjct: 807 VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ 866
Query: 787 L---QPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPK-----DGLVAGS 838
+ Q +E A + +L +E+ A+ D +L+ +M A K + LV +
Sbjct: 867 ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
Query: 839 GQE---GTRGLLPLRPGCGERPLAWLAPGDGRE--SEEAAGAGPRRRQAQDTEATQSPAP 893
G++ +R L+ G+R WL GR+ S +AA QA + EA Q
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA------LQAMEREAEQMGNE 980
Query: 894 APAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAA--GLEQPGARELPL-------- 943
+ + + + G V + + G + A LE+ EL +
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 944 ----LGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ-- 997
T ++A E + A RG E Q + E R + +EQ +++
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRG-LEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 998 --------QARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPE---EGE 1046
Q+ A G EP K A L Q Q E+ E E
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 1047 TKIALEREKDDMETK---LLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRV 1103
ALE + +E K L H + + + ++ + +++ H +E+ K + R
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQREL-AAFRTKVQDHSKAEDE--WKAQVARG 1216
Query: 1104 RQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEA 1163
RQE E S + +E+ +L + + E + L R ++ +L R+ L E
Sbjct: 1217 RQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAET 1276
Query: 1164 STHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELT 1223
+++ A+ E ++ QSL E + +K RV E L QE S EL
Sbjct: 1277 ASNSARAAERSSALREEVQSLRE----------EAEKQRVASENLRQELTSQAERAEELG 1326
Query: 1224 QTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE 1283
Q L+ Q++ L Q +H LV + A+ H LQ EQA A +
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAK-HLCQQLQAEQA-----AAEKR 1380
Query: 1284 HEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRA 1343
H ++L E+ ++A L+ + Q ++ +L +K + + ++L E A
Sbjct: 1381 HREEL----EQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ 1436
Query: 1344 LQATEEKQRGAEKQSRLLEEK 1364
L ++ +++R L E+
Sbjct: 1437 LSMLKKAHGLLAEENRGLGER 1457
Score = 82.8 bits (203), Expect = 2e-15
Identities = 280/1324 (21%), Positives = 500/1324 (37%), Gaps = 184/1324 (13%)
Query: 116 ELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEA---ESTKEAQNELFEAQ 172
E + A++A ASL S L +L + + E A + KE Q +L +
Sbjct: 483 EELEQASQAHGARLTAQVASLTSEL---TTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539
Query: 173 GQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQG 232
Q Q S+ + S S E Q++ V E+ H Q+LA +
Sbjct: 540 QQ-QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHA--QQLATAAEEREASL 596
Query: 233 LEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEES 292
E++ L+++ K+ + + QL + + S T+ + KA +V E
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Query: 293 GCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDE 352
C T + + + +E + ++ LQ ++ E
Sbjct: 657 ACVETARQEQHEAQAQVAELE-------LQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 353 KVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEK 412
+ + + +L+ E A+++ C + + + VEQ RER + + ERA +
Sbjct: 710 SLKVTK--GSLEEEKRRAADALEEQQ-RCISELKAETRSLVEQHKRERKELEE--ERAGR 764
Query: 413 RNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAAL 472
+ LE + L+QL E E RE + ++ AE E EQ ++ AA
Sbjct: 765 KGLE---------ARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC--EQLVKEVAAW 813
Query: 473 EWDVGRLQAEEAG----LREKLTLALKENSRLQKEIVEVVEKLSDSE------------- 515
Q EEA +E+L +E + ++E+ E EK++ E
Sbjct: 814 RERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNE 873
Query: 516 --RLALKLQKDLEFVLKDKLEPQSA--ELLAQEERFAAVLKEY---ELKCRDLQDRNDEL 568
L L + L+ V + ++ Q +L +E+ AA KE E R ++ +
Sbjct: 874 LAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
Query: 569 QAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEH 628
EL AR + P W + + RQ A + + + E +E+++
Sbjct: 934 SRELVKEPARAGDRQ--PEWLEEQQGRQFCSTQAALQAMEREAEQMGNE----LERLRAA 987
Query: 629 YQDLRTQLETKVNYYEREIAALKRNFEKERKDM--EQARRREVSV-----LEGQKADLEE 681
+ + Q + + ERE+A L + + + D+ E+A R E+ + L Q+ +
Sbjct: 988 LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047
Query: 682 LHEKSQEVIWGLQEQLQDTA--RGPEPEQMG----LAPCCTQALCGLALRHHSHLQQIRR 735
L E + + + Q+ A RG E Q+ L Q LA + H
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGA 1107
Query: 736 EAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALK--------- 786
++EA E +G L A R +LE+ Q + LE ERA +
Sbjct: 1108 QSEAAGRTEPTG-PKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET 1166
Query: 787 LQPCASEKRAQMCVS---LALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGT 843
LQ EK ++ S LA + EL R K D E E +A G +
Sbjct: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
Query: 844 RGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPS 903
L R + G+ +E + A + Q + A + ++ +
Sbjct: 1227 ISSLEEEVSILNRQVLE-KEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARA-A 1284
Query: 904 ERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLR 963
ER S ++ + + +E E ++ L Q EL + + + W+
Sbjct: 1285 ERSSALRE---EVQSLREEAEKQRVASENLRQ----ELTSQAERAEELGQELKAWQEKFF 1337
Query: 964 PAASCRGQAERLQAIQEERARSWSRGTQEQASE--------QQARAEGALEPGCHKHSVE 1015
+ + L +Q E TQ SE QQ +AE A H+ +E
Sbjct: 1338 Q------KEQALSTLQLEHT-----STQALVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386
Query: 1016 VARRGSLPSHLQLADPQGSWQEQLA----APEEGETKIALEREKDDMETKLLHLEDVVRA 1071
+++ + +L Q E + E+ T L EK +L L+
Sbjct: 1387 QSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK----- 1441
Query: 1072 LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQEL--EAAESTHDAQRKEIEVLKKDKE 1129
+ H L E +R R + L+ +L + R++ E A DA+ + EV +++ +
Sbjct: 1442 -KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV-QREAQ 1499
Query: 1130 KACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVR 1189
E+EV+ + + K V+VL+ Q +E R Q LT +E++
Sbjct: 1500 STARELEVMTAKYEGAK-------VKVLEERQRF-------QEER---QKLTAQVEQLEV 1542
Query: 1190 SGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQ 1249
++Q+ Q+++L +L +Q + Q + ESQ + Q +L + QAQ
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ--- 1599
Query: 1250 EVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLL 1309
L +++ AE ++ LQ E+A+ DA+++++++ L
Sbjct: 1600 ---LSQKEQAAEHYK---LQMEKAKTHYDAKKQQNQE----------------------L 1631
Query: 1310 QEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALN 1369
QE++ L++ ++N KEL E L LQ K + AE+ R L +VR+L
Sbjct: 1632 QEQLRSLEQLQKEN-------KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
Query: 1370 KLVS 1373
V+
Sbjct: 1685 AQVA 1688
Score = 76.3 bits (186), Expect = 2e-13
Identities = 239/1136 (21%), Positives = 414/1136 (36%), Gaps = 174/1136 (15%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
Q+L ++ Q+++ + + DL + EF + L +LTE+ K ++
Sbjct: 300 QDLKTEKSQMDRKINQLSEENGDLSFKLR---EFASHLQQLQDALNELTEEHSKATQEW- 355
Query: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQK- 502
L + + E+EL A + + LE LQ + + L E L+ L++N +K
Sbjct: 356 ------LEKQAQLEKEL--SAALQDKKCLEEKNEILQGKLSQLEEHLS-QLQDNPPQEKG 406
Query: 503 ----EIVEVVEKLSDSERLA---LKLQKDLEFVLKDKLEPQSAELLA-------QEERFA 548
+++++ ++ LA +LQ +E +L+ + Q A+LLA ++++ +
Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARVE-MLETERGQQEAKLLAERGHFEEEKQQLS 465
Query: 549 AVLKEYELKCRDLQDRNDELQ-------AELEGLWARLPKNRHSPSWSPDGRRRQLPGLG 601
+++ + + +L +EL+ A L A L + + + + ++L GL
Sbjct: 466 SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLK 525
Query: 602 PAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDM 661
A +T EQ + + QL + + E+++ + E R+D
Sbjct: 526 QQAKEKQAQLA----QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581
Query: 662 EQ-----ARRREVSVLEGQKA--DLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPC 714
Q A RE S+ E A LE L ++ + LQ+QLQ + Q +
Sbjct: 582 AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641
Query: 715 CTQ-----------ALCGLALRHHSHLQQIR-REAEAELSGELSGLGALPARRDLTLELE 762
+ C R H Q + E E +L E +L+
Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 763 EPPQG-----PLPRGSQRSEQLELERAL-KLQPCASEKRAQMCVSLALEEEELELARGKR 816
E Q + +GS E+ AL + Q C SE +A+ + + E + +R
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 817 VDGPSLEAEMQAL-----PKDGLVAGSGQEGTRGLLPLRPGCGE---RPLAWLAPGDGRE 868
LEA +Q L + ++ E C + AW + +
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 869 SEEAAGAGPRRRQAQDTEATQSPAP---APAPASHGPSERWSRMQPCGVDGDIVPKEPEP 925
EEA + Q + A A E S +Q ++ E
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELA----EL 877
Query: 926 FGASAAGLEQPGARELPLLGTERDASQTQPRM---------WEPPLRPAASCRGQAERLQ 976
A L+Q +E+ D S Q +M E +R A + A R
Sbjct: 878 HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR-- 935
Query: 977 AIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQ--LADPQGS 1034
+ +E AR+ R E EQQ R + + E + G+ L+ L + QG
Sbjct: 936 ELVKEPARAGDR-QPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ 994
Query: 1035 WQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA-LEKHVDLREND-RLEFHRLSEE 1092
QE+ E ++ ER + + L LE RA LE + N+ R+EF L E
Sbjct: 995 QQEERGQQEREVARLTQERGRAQAD---LALEKAARAELEMRLQNALNEQRVEFATLQEA 1051
Query: 1093 NTLLKNDLGRVRQELEAAESTHDAQRKEIEVL------------KKDKEKACS------- 1133
+ QEL AQ KE+E L KK+KE A
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 1134 ---------EMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSL 1184
++E L + + Q + + L + +A E ++ L L
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171
Query: 1185 EEVVRSGQQQSDQIQKLRVELECLN---QEHQSLQLPW--------------SELTQTLE 1227
EE + + + EL Q+H + W + L +LE
Sbjct: 1172 EEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLE 1231
Query: 1228 ESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAEL-HRLLSLQGEQA------------- 1273
E + + + ++ +++ L+ + + ++ +L RL LQ E A
Sbjct: 1232 E-EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290
Query: 1274 RRRLDAQREEHEKQLKATE----------ERVEEAEMILKNMEMLLQEKVDKLKEQFEKN 1323
R + + REE EKQ A+E ER EE LK + +K L ++
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350
Query: 1324 TKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSR-LLEEKVRALNKLVSRIAPA 1378
T + L+ EL + HL + LQA +Q AEK+ R LE+ +A L + + A
Sbjct: 1351 TSTQALVSEL-LPAKHLCQQLQA---EQAAAEKRHREELEQSKQAAGGLRAELLRA 1402
Score = 63.9 bits (154), Expect = 1e-09
Identities = 251/1165 (21%), Positives = 438/1165 (37%), Gaps = 174/1165 (14%)
Query: 144 ASLESVESPKSDEEAESTKE-AQNELFEAQGQ-----LQTWDSEDFGSPQKSCSPSFDTP 197
A E E + EE ++ E A+ E EAQ Q LQ + + ++ + D
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700
Query: 198 ESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEE 257
+ Q++ + E L V + G L E++ Q E + + ++Q + LEE
Sbjct: 701 QEQLQALKESLKV-TKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEE 759
Query: 258 FQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDD 317
+ G E L ++ ++ E T S L + + +
Sbjct: 760 ERAGRKGLEARLQQLGEAHQAETEVLRR-ELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
Query: 318 GS-------GFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTV 370
S G F +Q++ + +E + R+ LQ EKV +E +EL
Sbjct: 819 DSQQEEAQYGAMFQEQLMTL--KEECEKARQELQE----AKEKVAGIES----HSELQI- 867
Query: 371 DSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQ 430
+ QQ LA H L+ QV++ K DL +++ KE+ + LE
Sbjct: 868 --SRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV----ARLET 921
Query: 431 LTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQ----RAALEWDVGRLQAEEAGL 486
L K + E RE + + + E EQ RQ +AAL+ +AE+ G
Sbjct: 922 LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ--AMEREAEQMGN 979
Query: 487 R-EKLTLAL--------KENSRLQKEIVEVVEKLSDSER-LALK--LQKDLEFVLKDKLE 534
E+L AL +E + ++E+ + ++ ++ LAL+ + +LE L++ L
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN 1039
Query: 535 PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRR 594
Q E +E A L E E K ++L A+L GL A K + +
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQEL--------AKLRGLEAAQIKELEELRQTVKQLK 1091
Query: 595 RQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNF 654
QL S G + + TE +++ ++ ++LE + + + +L+R+
Sbjct: 1092 EQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV-SKLEQQCQKQQEQADSLERSL 1150
Query: 655 EKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQL-------QDTARGPEPE 707
E ER + R + L+GQ + + SQ + Q +L QD ++ +
Sbjct: 1151 EAERASRAE-RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
Query: 708 QMGLAPCCTQA-----LCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLE-- 760
+ +A +A L S L + E E E S EL L + + LE
Sbjct: 1210 KAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE-SKELKRLVMAESEKSQKLEER 1268
Query: 761 ---LEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRV 817
L+ R ++RS L E +Q E Q S L +E A
Sbjct: 1269 LRLLQAETASNSARAAERSSALREE----VQSLREEAEKQRVASENLRQELTSQAERAEE 1324
Query: 818 DGPSLEA-------EMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESE 870
G L+A + QAL L S Q LLP + C + ++E
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL-----------QAE 1373
Query: 871 EAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASA 930
+AA R + + ++ Q+ A E G+++P
Sbjct: 1374 QAAAEKRHREELEQSK--QAAGGLRAELLRAQREL----------GELIP---------- 1411
Query: 931 AGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERA--RSWSR 988
L Q A + ER A Q + A AE+L +++ +R
Sbjct: 1412 --LRQKVAEQ------ERTAQQLR-----------AEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 989 GTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQ------EQLAAP 1042
G E+A+ + E L+ K+ E+A + + +LA+ Q Q E + A
Sbjct: 1453 GLGERANLGRQFLEVELDQAREKYVQELAAVRA-DAETRLAEVQREAQSTARELEVMTAK 1511
Query: 1043 EEG-ETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLG 1101
EG + K+ ER++ E + L + V LE V RE + + LS++
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQ--VEQLE--VFQREQTK-QVEELSKKLADSDQASK 1566
Query: 1102 RVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+Q+L+A ++ ++E + L+ + +++ + ++YK Q+ +
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM-----------E 1615
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSE 1221
+A TH ++ +Q +SLE++ + ++ LR E E L E Q L E
Sbjct: 1616 KAKTHYDAKKQQNQELQEQLRSLEQLQKENKE-------LRAEAERLGHELQQAGLKTKE 1668
Query: 1222 LTQTLEESQDQVQGAHLRLRQAQAQ 1246
QT QV+ ++ A Q
Sbjct: 1669 AEQTCRHLTAQVRSLEAQVAHADQQ 1693
Score = 54.3 bits (129), Expect = 8e-07
Identities = 74/331 (22%), Positives = 141/331 (42%), Gaps = 46/331 (13%)
Query: 1069 VRALEKHV-DLREN-DRLEFHRLSEENTLLKND--LGRVRQELEAAESTHDAQR------ 1118
+R L+K + D R N D LE L + D + ++Q ++ ++ Q
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEP 275
Query: 1119 KEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
KE+E L+ E + +Q Q+ K + SQ++ ++ QL +E + E +Q
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 1179 MLTQSLEEVVRSGQQQSDQIQKLRVELE-----------CLNQEHQSLQLPWSELTQTLE 1227
L +L E+ + + + + + +LE CL ++++ LQ S+L + L
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 1228 ESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRR---LDAQREEH 1284
+ QD Q + + L +V + + + + L+ Q + R L+ +R +
Sbjct: 396 QLQDNPP-------QEKGEVLGDV--LQLETLKQEAATLAANNTQLQARVEMLETERGQQ 446
Query: 1285 EKQLKATEERVEEAEMILKNMEMLLQEKVDKL---KEQFEKNTKSD---------LLLKE 1332
E +L A EE + L ++ LQ + L KE+ E+ +++ L E
Sbjct: 447 EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
Query: 1333 LYVENAHLVRALQATEE-KQRGAEKQSRLLE 1362
L NA + + Q KQ+ EKQ++L +
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 102 bits (255), Expect = 2e-21
Identities = 229/1046 (21%), Positives = 405/1046 (38%), Gaps = 96/1046 (9%)
Query: 382 YHQELSYQQGQVEQLARERDKAR-QDLERAEKRNLEFVKEMDDC-----HSTLEQLTEKK 435
Y +E QQ + + L ER+K R Q+ ER +++ + ++ + Q EKK
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 436 IKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALK 495
+ E+ +E LLR E E R WE+ +R++ L+ + +L EE REK L +
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE---REKRRLQER 1046
Query: 496 ENS-RLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEY 554
E R ++E+ + E+L ER + Q+ K++ Q E L +EE +E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 555 ELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPV 614
E +CR+ +ELQ E E L + R RR++L +
Sbjct: 1107 ERQCRE----EEELQQEEEQLLREEREKR---------RRQELER------QYREEEEVQ 1147
Query: 615 SIETELMMEQ-VKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLE 673
E +L+ E+ K Q+L Q + + E L+ EK R++ E+ R E +
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 674 GQKADLEELHEKSQEVIWGLQEQLQDTAR-------GPEPEQMGLAPCCTQALCGLALRH 726
++ ++ ++ W + + ++ R G E EQ +Q + +
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE-DSQLRDRQSQQD 1266
Query: 727 HSHL--QQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERA 784
HL +Q R+ E E P L E ++ + + + + L ER
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 785 LKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGS-----G 839
K + ++++ + L E EE L R +R D E E++ +
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQER-DRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 840 QEGTRGLL--PLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAP 897
QE R L + C ER D + EE + R + E Q
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 898 ASHGPSE---RWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDAS--Q 952
E R R + + ++ + E + E L ERD +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 953 TQPRMWEPP---LRPAASCRGQAERLQAIQEE-RARSWSRGTQ-EQASEQQARAEGALEP 1007
+ R EP L Q + + +QEE + R RG Q Q +++ R E L
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 1008 GCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKI-----ALEREKDDMETKL 1062
+ +++R Q D + +EQ +E E K L R++ +
Sbjct: 1566 --EREEQQLSR--------QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ--- 1612
Query: 1063 LHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRK--- 1119
L E + E L+E + + HR + L+ + RQE E + HD RK
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE-QQLRHDRDRKFRE 1671
Query: 1120 EIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQM 1179
E ++L++ +E+ E + + + Q R ++ Q + R Q+
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 1180 LTQSLEEVVRSGQQ-----QSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQ 1234
++ +E +R ++ + +Q++ R E + QE +L Q EE Q + Q
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 1235 GAHLRLRQAQ--AQHLQEVRLVPQDRVAELH-RLLSLQGEQARRRLDAQREEHEKQLKAT 1291
+ + R+ + Q +E +L PQ R + LQ E+ +RL R+E ++Q +A
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL---RQERDRQYRA- 1847
Query: 1292 EERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQ 1351
EE+ E + + L QE+ K +++ E+ + + + ++ E H Q E K
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH----RQVGEIKS 1903
Query: 1352 RGAEKQSRLLEEKVRALNKLVSRIAP 1377
+ + RLLE + R +P
Sbjct: 1904 QEGKGHGRLLEPGTHQFASVPVRSSP 1929
Score = 99.4 bits (246), Expect = 2e-20
Identities = 229/1024 (22%), Positives = 402/1024 (39%), Gaps = 155/1024 (15%)
Query: 394 EQLARER-DKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRS 452
+Q RER D+ Q+ E E R E V ++ L++ ++ + L++ + L R
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEE--EKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 453 EVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLS 512
E+ ER+ E+ +QR E + R Q EE +++ +E Q+E E +
Sbjct: 285 ELRRERQE--EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342
Query: 513 DSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAEL 572
ER +L+++ E +++ E Q +E R + +E +L+ R +L+ E
Sbjct: 343 QEERREQQLRREQE---EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 573 EGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQD- 631
+ R + R + + R+ L E +++ +E +D
Sbjct: 400 Q--LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457
Query: 632 LRTQLETKVNYYEREIAALKRNFEKERKDM----------EQARRREVSVLEGQKADLEE 681
L+ + ET+ + ER LKR+ E+ER++ EQ RRE + Q+ E+
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 682 LHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAEL 741
++ +E +E+LQ R QQ+RRE E
Sbjct: 518 RLKRQEE-----EERLQQRLRSE--------------------------QQLRREQEE-- 544
Query: 742 SGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVS 801
RR+ L+ EE + R QR ++ + ER +L E+R Q
Sbjct: 545 ------------RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR--- 589
Query: 802 LALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWL 861
L E+EE R KR + LE E + + L +E R L ER L
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERR--EQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 862 APGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPK 921
RE +E RR Q E + H R + ++ +
Sbjct: 648 R----REQQE------RREQRLKREEEEERLEQRLKREHEEERR---------EQELAEE 688
Query: 922 EPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEE 981
E E +L E +A Q +++ P + R Q + + + E
Sbjct: 689 EQEQARERIKSRIPKWQWQL-----ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743
Query: 982 RARSWS---RGTQEQASEQQAR-------AEGALEPGCHKHSVEVARRGSLPSHLQLADP 1031
W R ++Q E+Q R AE E G + S R L+ +
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803
Query: 1032 QGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLREND----RLEFH 1087
Q Q L EE E + RE++ E + L E+ ++ E+ L+E + +
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREK-ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 1088 RLSEENTL-------LKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC-SEMEVLN 1139
R S+E L+ + R R L A + + RKE ++L++++E+ E E
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 1140 RQNQNYK----DQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQS 1195
RQ Q + +QL Q ++L+ +E Q + ++R + L Q E+++ G++
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-KKLQQKEEQLL--GEEPE 979
Query: 1196 DQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQ--EVRL 1253
++ R E E +E + LQ E Q L E +++ + + + LQ E +L
Sbjct: 980 ---KRRRQEREKKYREEEELQ---QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 1254 VPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEE---RVEEAEMILKNMEMLLQ 1310
+ ++R E RL Q + + R + + ++ E+QL E R +E E + E L Q
Sbjct: 1034 LREER--EKRRL---QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 1311 EKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
E+ L+E+ EK + + R Q EE++ E++ L EE+ + +
Sbjct: 1089 EEEQLLREEPEKRRRQE--------------RERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 1371 LVSR 1374
+ R
Sbjct: 1135 ELER 1138
Score = 95.1 bits (235), Expect = 4e-19
Identities = 225/1029 (21%), Positives = 393/1029 (38%), Gaps = 178/1029 (17%)
Query: 384 QELSYQQGQVEQLARERD-----KARQDLERAEKRNLEFVKEMDDC--HSTLEQLTEKKI 436
+E S +Q ++EQ R+R + RQ+ + E+R E +++ C H T E E+++
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE-EEQLQSCKGHETEEFPDEEQL 210
Query: 437 KHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKE 496
+ RE L L R E +++ ++ RQ + + EE R++ T+ KE
Sbjct: 211 RR-----RELLELRRKGREEKQQ---QRRERQDRVFQ------EEEEKEWRKRETVLRKE 256
Query: 497 NSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYEL 556
+LQ+E EPQ L +EE L+ EL
Sbjct: 257 EEKLQEE------------------------------EPQRQRELQEEEEQLRKLERQEL 286
Query: 557 KCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSI 616
+ ++R +E Q + RL + + + RR Q
Sbjct: 287 R----RERQEEEQQQ-----QRLRREQQLRRKQEEERREQ-------------------- 317
Query: 617 ETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQK 676
+ E +Q + Q+ R + + + ER L+R E+ER++ + R +E E Q
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 677 ADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHL---QQI 733
++L + Q ++QL+ + +Q+ LR L QQ+
Sbjct: 378 RREQQLRREQQ---LRREQQLRREQQLRREQQLRREQ---------QLRREQQLRREQQL 425
Query: 734 RREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELE-RALKLQPCAS 792
RRE E E + RR+ L+ E+ + + + +E+ E E R +L+
Sbjct: 426 RREQEEERHEQKHE----QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 793 EKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPG 852
E+R + + L EE + R ++ E + K Q+ R LR
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 853 CGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPC 912
ER L + EE RR Q E + +R R Q
Sbjct: 542 QEERREQLL-----KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 913 GVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQA 972
++ + +E E LEQ RE L E + + Q + R Q
Sbjct: 597 RLEQRLKREEVE-------RLEQEERREQRLKREEPEEERRQQLLKSEEQEE----RRQQ 645
Query: 973 ERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQ 1032
+ + QE R + R +E+ EQ+ + E E + E+A + ++
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEE----RREQELAEEEQEQARERIKSRI 701
Query: 1033 GSWQEQLAAPEEG-ETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSE 1091
WQ QL + + ++K+ K + + + E+ R E + +E +R + E
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761
Query: 1092 E---------NTLLKNDLGR--------VRQELEAAESTHDAQRKEIEVLKKDKEKACSE 1134
E K++ GR +R++ E + Q++E L +++EK
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK---- 817
Query: 1135 MEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQ 1194
E RQ + + +L L QL + Q Q EE + Q +E RS +Q+
Sbjct: 818 -EQRRRQRREREKELQFLEEEE-QLQRRERAQQLQEEEDGL------QEDQERRRSQEQR 869
Query: 1195 SDQIQKLRVELECLNQEH-----QSLQLPWSELTQTLEESQDQVQ--GAHLRLRQAQAQH 1247
DQ + ++E E + H +LQ + Q L+E ++++Q R RQ Q +
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 1248 LQEVRLVPQDRVAELHRLLSLQGEQARR-------RLDAQREEHEKQLKATE---ERVEE 1297
+E + Q E +LL + E+ RR R D + ++ E+QL E R +E
Sbjct: 930 YREEEQLQQ----EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 1298 AEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQ 1357
E + E L QE+ L+E+ EK + + + LQ EE+ E++
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQE------WERQYRKKDELQQEEEQLLREERE 1039
Query: 1358 SRLLEEKVR 1366
R L+E+ R
Sbjct: 1040 KRRLQERER 1048
Score = 94.0 bits (232), Expect = 9e-19
Identities = 230/1027 (22%), Positives = 412/1027 (40%), Gaps = 119/1027 (11%)
Query: 384 QELSYQQGQVEQLARERD-KARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQG 442
+E ++ Q ++L RE+ + +Q+ ER E++ E +E + E+ E++++ ++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQ--EERREQQERREQQEERREQQLRREQEE 345
Query: 443 YRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQK 502
RE+ LR E E ER EQ R+ E +L+ E+ RE+ L+ +L++
Sbjct: 346 RREQQ--LRREQEEERR---EQQLRREQEEERREQQLRREQQLRREQ---QLRREQQLRR 397
Query: 503 EI-VEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDL 561
E + ++L ++L + Q E L+ + E + E ++ER +E LK R+
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER-----REQRLK-REQ 451
Query: 562 QDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM 621
++R D L+ E E + + + RR+ + +E E
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRE---------------RWLKLEEEER 496
Query: 622 MEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEE 681
EQ + Q LR + E ER LKR E+ER ++Q R E + Q+ E+
Sbjct: 497 REQQERREQQLRREQE------ERREQRLKRQEEEER--LQQRLRSEQQLRREQEERREQ 548
Query: 682 LHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAEL 741
L ++ +E + + Q R E + L L Q+++RE E L
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQL----------LKREEERRQQRLKREQEERL 598
Query: 742 SGELSGLGA----LPARRDLTLELEEPPQGPLPRGSQ--RSEQLELERALKLQPCASEKR 795
L RR+ L+ EEP + R Q +SE+ E R +L+ E+R
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEE---ERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 796 AQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGE 855
Q L EEEE L + L+ E + ++ +A QE R + R +
Sbjct: 656 EQR---LKREEEEERLEQ-------RLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705
Query: 856 RPLAWLAPGDGRESEEAAGA----GPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQP 911
L + D R+S+ + G RRRQ Q+ + + + ER R Q
Sbjct: 706 WQLE--SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL----QWQEEERAHRQQQ 759
Query: 912 CGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQ 971
+ + S G ++ AR ER + + E P + Q
Sbjct: 760 EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819
Query: 972 AERLQAIQEERARSWSRGTQ----EQASEQQARAEGALEPGCHKHSVEVAR----RGSLP 1023
R + +E+ + Q E+A + Q +G E + S E R R L
Sbjct: 820 RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879
Query: 1024 S------HLQLADPQGSWQ---EQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEK 1074
H A P Q EQ EE E EREK + + + + ++
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 1075 HVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSE 1134
L +R + R E K+ + ++E E +R+E E +++E+ E
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Query: 1135 MEVLNRQNQ------------NYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQ 1182
E L R+ + KD+L Q ++L+ +E Q + ++R + L Q
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE-EELQQ 1058
Query: 1183 SLEEVV---RSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLR 1239
E+++ R +++ + ++ R E E +E Q L+ E + + +++
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR---EEPEKRRRQERERQCREEEE 1115
Query: 1240 LRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEER-VEEA 1298
L+Q + Q L+E R + R EL R + E + REE EK+ + ER E
Sbjct: 1116 LQQEEEQLLREER--EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 1299 EMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQS 1358
E + + E LL+E+ +K +++ E+ + + L+ + + ++ + Q EK++
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 1359 RLLEEKV 1365
+ + KV
Sbjct: 1234 AVRDNKV 1240
Score = 74.3 bits (181), Expect = 7e-13
Identities = 191/872 (21%), Positives = 325/872 (37%), Gaps = 125/872 (14%)
Query: 530 KDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNR------ 583
+ K + Q EL EE+ K+ L+ RD Q R++EL + + W + R
Sbjct: 138 RQKRQEQERELAEGEEQSE---KQERLEQRDRQRRDEELWRQRQE-WQEREERRAEEEQL 193
Query: 584 -----HSPSWSPDG---RRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQ 635
H PD RRR+L L G E +Q +E QD Q
Sbjct: 194 QSCKGHETEEFPDEEQLRRRELLELRRKG-------------REEKQQQRRER-QDRVFQ 239
Query: 636 LETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQ--KADLEELHEKSQEVIWGL 693
E + + +RE K E++ ++ E R+RE+ E Q K + +EL + QE
Sbjct: 240 EEEEKEWRKRETVLRKE--EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE----- 292
Query: 694 QEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPA 753
+EQ Q R QQ+RR+ E E
Sbjct: 293 EEQQQQRLRRE--------------------------QQLRRKQEEE------------- 313
Query: 754 RRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELAR 813
RR+ E E +R EQ E R +L+ E+R Q L E+EE +
Sbjct: 314 RREQQEERREQ--------QERREQQEERREQQLRREQEERREQQ---LRREQEEERREQ 362
Query: 814 GKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAA 873
R + E Q + L ++ R LR R L E+
Sbjct: 363 QLRREQEEERREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 874 GAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGL 933
+ R+ Q+ E + E+ R + + E E
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 934 EQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQ 993
++ RE L E + + Q R E LR R + + +EER + R Q+
Sbjct: 480 QEEERRERWLKLEEEERREQQERR-EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 994 ASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
EQ+ R E L+ K +E RR +L Q ++QL EE + L+R
Sbjct: 539 RREQEERREQLLKREEEKR-LEQERREQ-----RLKREQEERRDQLLKREEERRQQRLKR 592
Query: 1054 EKDDMETKLLHLEDVVRALE--------KHVDLRENDRLEFHRLSEENTLLKNDLGRVRQ 1105
E+++ + L E+V R + K + E R + + E+ + L R +Q
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 1106 ELEAAESTHDAQRKEIEV-LKKDKEKACSEMEVLNRQNQNYKDQL-SQLNVRVLQLGQEA 1163
E + + + +E LK++ E+ E E+ + + ++++ S++ QL EA
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 1164 STHQAQ--NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSE 1221
Q++ + + Q Q EE R + + ++ R + +E Q W
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ-QQEEEQRRDFTWQW 771
Query: 1222 LTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQR 1281
+ E Q A LR+ + + L+ ++R R L + E+ +RR +
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRA-----EERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 1282 EEHEKQLKATEE---RVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENA 1338
E E Q EE R E A+ + + + L +++ + ++ ++ K L+E
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 1339 HLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
H + A A +E+ R K+ +LL+E+ L +
Sbjct: 887 HTLYAKPALQEQLR---KEQQLLQEEEEELQR 915
Score = 72.4 bits (176), Expect = 3e-12
Identities = 223/1070 (20%), Positives = 389/1070 (36%), Gaps = 158/1070 (14%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEK 434
+Q L QE QQ Q+ + +ER + R E E+R + +K + ++L E+
Sbjct: 630 RQQLLKSEEQEERRQQ-QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 435 KIKHLEQGYRERLS----LLRSEVEA----------------------------ERELFW 462
+ + + + R+ L SE +A E EL W
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 463 ---EQAHRQRAALEWD---VGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSER 516
E+AHRQ+ E + QAEE R + L+ + R Q+E E+ E+
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808
Query: 517 LALKLQKDLEFVLKDKLE-PQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGL 575
L +++ E + + E + + L +EE+ + + + LQ+ D LQ + E
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQL-----QRRERAQQLQEEEDGLQEDQER- 862
Query: 576 WARLPKNRHSPSW-----SPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQ 630
R + R W RRR PA L + E E E+++ +
Sbjct: 863 -RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE---EELQREER 918
Query: 631 DLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVI 690
+ R + E + Y E E L++ E+ ++ + RRR+ + E + K +++
Sbjct: 919 EKRRRQEQERQYREEE--QLQQEEEQLLREEREKRRRQ---------ERERQYRKDKKL- 966
Query: 691 WGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGA 750
+Q ++ G EPE+ R ++ R E E + E
Sbjct: 967 ----QQKEEQLLGEEPEKR---------------RRQEREKKYREEEELQQEEE------ 1001
Query: 751 LPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELE 810
+ L E E+ + R ++ ++L+ E L+ ++R Q EEEEL+
Sbjct: 1002 ----QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 811 LARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESE 870
+ + Q L + Q+ LL RE
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL-------------------REEP 1098
Query: 871 EAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKE-----PEP 925
E R RQ ++ E Q R + + ++ +E EP
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 926 FGASAAGLEQPGARELPLLGTE----RDASQTQPRMWEPPLRPAASCRGQAERLQAIQEE 981
LE+ E L E R+ + + + E R + Q +R Q ++E
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ-KRKQRYRDE 1217
Query: 982 RARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAA 1041
RS + E E R G L D Q EQ
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 1042 PEEGETKIALEREKDDMETKLLHLEDVV------RALEKHVDLRENDRLEFHRLSEENTL 1095
E E + +R++ E + L E+ R ++ L +R E R E +
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337
Query: 1096 LKND--LGRVRQELEAAESTHDAQRKEIEVLKKDK-EKACSEMEVLNRQNQNYK----DQ 1148
+ + L + R+E D + +E E+ +++ K E + L RQ + K +Q
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397
Query: 1149 LSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECL 1208
+ R QL Q+ + E+ Q+ Q + R +QQ + ++ R LE
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQ-----QLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 1209 NQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS- 1267
Q Q + E Q L+E ++Q R R+ + Q++R +DR L S
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE-QQLRRQERDRKFREQELRSQ 1511
Query: 1268 ------LQGEQARRRLDAQRE--EHEKQLKATE---ERVEEAEMILKNMEMLLQEKVDKL 1316
L+ EQ R QR+ + E+QL+ E +R ++ + + E L QE+ ++
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 1317 KEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVR 1366
+ E++ K L+E V R E++ R E Q +L +E+ R
Sbjct: 1572 LSRQERDRK--FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Score = 61.6 bits (148), Expect = 5e-09
Identities = 95/453 (20%), Positives = 187/453 (41%), Gaps = 36/453 (7%)
Query: 947 ERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALE 1006
+RD + +W R + + ER +A +E+ T+E E+Q R LE
Sbjct: 163 QRDRQRRDEELW----RQRQEWQEREER-RAEEEQLQSCKGHETEEFPDEEQLRRRELLE 217
Query: 1007 PGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALE-----REKDDMETK 1061
+ +R + + + W+++ + E K+ E RE + E +
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277
Query: 1062 LLHLEDVVRALEKHVDLRENDRL----EFHRLSEENTLLKNDLGRVRQELEAAESTHDAQ 1117
L LE E+ + ++ RL + R EE + + R +QE + Q
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 1118 RKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTI 1177
+ E ++ +++ E E R+ Q ++Q + + L+ Q+ Q E ++
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Query: 1178 QMLTQSLEEVVRSGQ----QQSDQIQKLRVELECLNQEHQSLQLPWSE-LTQTLEESQDQ 1232
+ + +++ R Q QQ + Q+LR E E E + Q + L + EE +D
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457
Query: 1233 VQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATE 1292
++ R Q + Q+++ ++ E R L L+ E+ R Q+E E+QL+ +
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRE--RWLKLEEEERRE----QQERREQQLRREQ 511
Query: 1293 ERVEEAEMILKNMEMLLQEKVDKLKE-QFEKNTKSDLLLK---ELYVENAHLVRALQATE 1348
E E + + E LQ+++ ++ + E+ + + LLK E +E + L+ +
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 1349 EKQRG-------AEKQSRLLEEKVRALNKLVSR 1374
E++R +Q RL E+ L + + R
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 100 bits (248), Expect = 1e-20
Identities = 237/1106 (21%), Positives = 437/1106 (39%), Gaps = 191/1106 (17%)
Query: 352 EKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAE 411
E+ N+L + EL ++ +A LA QEL +E E ++ Q L+ +
Sbjct: 887 EEKNILAEQLQAETELFA-EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 412 KRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAA 471
K+ +++++ EQL E E+G R++L L + EA+
Sbjct: 946 KKMQAHIQDLE------EQLDE------EEGARQKLQLEKVTAEAK-------------- 979
Query: 472 LEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKD 531
+ +++ E L ++ + +KE ++ I E +L++ E A L K +++
Sbjct: 980 ----IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK-----IRN 1030
Query: 532 KLEPQSAEL---LAQEERFAAVLKEYELKC----RDLQDRNDELQAELEGLWARLPKNRH 584
K E ++L L +EE+ L++ + K DLQD+ ELQA+++ L +L K
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK--- 1087
Query: 585 SPSWSPDGRRRQLPGL---GPAGISFLGNSAPVSIETELMMEQVKEHYQD---LRTQLET 638
+ +L G G N+ V E + + +++E ++ R + E
Sbjct: 1088 --------KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 639 KVNYYEREIAALKRNFEKE------RKDMEQARRREVSVLE--------GQKADLEELHE 684
+ E+ ALK E ++++ R +EV+ L+ +A ++++ +
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 685 KSQEVIWGLQEQLQDTAR---GPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAE--- 738
+ + L EQL+ R E + GL + C + + LQQ++ E+E
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV-----LQQVKAESEHKR 1254
Query: 739 AELSGELSGLGALPARRD-LTLELEEPP---QGPLPRGSQRSEQLELERALKLQPCAS-E 793
+L ++ L A + D L +EL E Q L S E+ E + + AS E
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 794 KRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGT-RGLLPLRPG 852
+ Q L EE +L R+ LE E +L + ++ + +L L+
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIR--QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 853 CGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPC 912
+ ES E A +++ +D EA A A + +R+Q
Sbjct: 1373 LADTKKKVDDDLGTIESLEEA----KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ- 1427
Query: 913 GVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQA 972
+ D + + + A+ LE+ + LL E+ S A R +A
Sbjct: 1428 --ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY-----------AEERDRA 1474
Query: 973 ERLQAIQEERARSWSRGTQE--QASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLAD 1030
E +E +A S +R +E +A E+ R L R + + D
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQL-------------RADMEDLMSSKD 1521
Query: 1031 PQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLR-----ENDRLE 1085
G +L ++K ALE++ ++M T+L LED ++A E LR + + +
Sbjct: 1522 DVGKNVHELE-----KSKRALEQQVEEMRTQLEELEDELQATED-AKLRLEVNMQAMKAQ 1575
Query: 1086 FHR----LSEENTLLKNDLGRVRQELEAAESTHDAQR-------KEIEVLKKDKEKACSE 1134
F R E+N K L + +ELEA QR K++E+ KD E ++
Sbjct: 1576 FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE---AQ 1632
Query: 1135 MEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQ 1194
+E N+ QL +L ++ +Q + EE R S +E+ ++
Sbjct: 1633 IEAANKARDEVIKQLRKLQAQM-------KDYQRELEEARA-------SRDEIFAQSKES 1678
Query: 1195 SDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGA------------HLRLRQ 1242
+++ L E+ L +E S + Q +E D++ + L R
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 1243 AQAQHLQEVRLVPQDRVAELHRLLSLQGE----------QARRRLDAQREEHEKQLKATE 1292
AQ + E + + + R +LQ + A ++ D R++ E+Q K +
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 1293 ERVEEAEMILKN----MEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATE 1348
+++E E +K+ L+ K+ +L+EQ E+ K +L ++ +
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 1349 EKQRGAEKQSRLLEEKVRALNKLVSR 1374
E +R Q + EK A K + R
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKR 1884
Score = 84.3 bits (207), Expect = 7e-16
Identities = 225/1038 (21%), Positives = 425/1038 (40%), Gaps = 184/1038 (17%)
Query: 374 VQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTE 433
V Q A Y + +Q +V + + + E + ++ E +K + +L E
Sbjct: 818 VLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEE 877
Query: 434 KKIKHLEQGYRERLSLLRSEVEAERELFWE-QAHRQRAA-----LEWDVGRLQAEEAGLR 487
+ KH Q E ++L +++AE ELF E + R R A LE + L++
Sbjct: 878 MERKH--QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935
Query: 488 EKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERF 547
E+ + E ++Q I ++ E+L + E KLQ + + + K++ E+L E++
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE-KVTAEAKIKKMEEEILLLEDQN 994
Query: 548 AAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISF 607
+ +KE +L ++DR E ++L + + + +
Sbjct: 995 SKFIKEKKL----MEDRIAECSSQL----------------AEEEEKAK----------- 1023
Query: 608 LGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRR 667
N A + + E+M+ ++E LK+ EK R+++E+A+R+
Sbjct: 1024 --NLAKIRNKQEVMISDLEER---------------------LKKE-EKTRQELEKAKRK 1059
Query: 668 EVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHH 727
L+G+ DL++ + Q I L+ QL A+ E Q LA + L H
Sbjct: 1060 ----LDGETTDLQDQIAELQAQIDELKLQL---AKKEEELQGALARGDDETL------HK 1106
Query: 728 SHLQQIRREAEAEL--------SGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQL 779
++ ++ RE +A++ S + S A +RDL+ ELE + +
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE-------------ALKT 1153
Query: 780 ELERALKLQPCASE---KRAQMCVSL--ALEEE----ELELARGKRVDGPSLEAEMQALP 830
ELE L E KR Q L ALEEE E ++ ++ +LE + L
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Query: 831 KDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQS 890
+ + ++ +GL + LA + + ++ +R+ D + +
Sbjct: 1214 QAKRFKANLEKNKQGL-----ETDNKELAC----EVKVLQQVKAESEHKRKKLDAQVQE- 1263
Query: 891 PAPAPAPASHGP------SERWSRMQPCGVDGDIVPKEPEP----FGASAAGLEQPGARE 940
A S G +E+ S++Q + + +E E F AA LE
Sbjct: 1264 ---LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 941 LPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSR---GTQEQASEQ 997
LL E Q +R + + Q +EE ++ + Q Q ++
Sbjct: 1321 QELLQEET----RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 998 QARAE---GALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALERE 1054
+ + + G +E S+E A++ L L+ Q ++ LA + +TK L++E
Sbjct: 1377 KKKVDDDLGTIE------SLEEAKKKLLKDAEALS--QRLEEKALAYDKLEKTKNRLQQE 1428
Query: 1055 KDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTH 1114
DD+ L H V LEK ++ D+L L+EE ++ R +E + AE+
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQ--KKFDQL----LAEEKSIS----ARYAEERDRAEA-- 1476
Query: 1115 DAQRKEIEVLKKDK--EKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEE 1172
+A+ KE + L + E+A E RQN+ + + L +G+ + H+ + +
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK--NVHELEKSK 1534
Query: 1173 HRVTIQMLTQSLEEVVRSGQQQSDQIQ-----KLRVELECLNQEHQSLQLPWSELTQTLE 1227
+ L Q +EE+ ++ D++Q KLR+E+ Q+++ + QT +
Sbjct: 1535 -----RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM-----QAMKAQFERDLQTRD 1584
Query: 1228 ESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQ 1287
E ++ + RL Q + L E L + + L + E + L+AQ E K
Sbjct: 1585 EQNEEKK----RLLIKQVREL-EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 1288 LKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQAT 1347
+++ + + +K+ + L+E E F ++ +S+ LK L E L L ++
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 1348 EEKQRGAEKQSRLLEEKV 1365
E +R AE++ L +++
Sbjct: 1700 ERARRHAEQERDELADEI 1717
Score = 75.1 bits (183), Expect = 4e-13
Identities = 103/463 (22%), Positives = 195/463 (42%), Gaps = 85/463 (18%)
Query: 962 LRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGS 1021
++P Q E LQA EE + E+Q + EG LE KH + +
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLK---------VKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 1022 LPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLREN 1081
L LQ + E A EE ++A ++++ LE+++ LE V+ E
Sbjct: 892 LAEQLQ------AETELFAEAEEMRARLAAKKQE---------LEEILHDLESRVEEEE- 935
Query: 1082 DRLEFHRLSEENTLLKNDLGRVR---QELEAAESTHDAQRKEIEVLKKDKEKACSEM--E 1136
E N +L+N+ +++ Q+LE + R+++++ K E +M E
Sbjct: 936 ---------ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEE 986
Query: 1137 VLNRQNQNYK---------DQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEV 1187
+L ++QN K D++++ + ++ + ++A + V I L + L++
Sbjct: 987 ILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE 1046
Query: 1188 VRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLR-------- 1239
++ Q+ +KL E L + LQ EL L + ++++QGA R
Sbjct: 1047 EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHK 1106
Query: 1240 ------LRQAQAQ--HLQE-----------VRLVPQDRVAELHRLL-----SLQGEQARR 1275
+R+ QAQ LQE +D EL L +L A++
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 1276 RLDAQREEHEKQL-KATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKE-- 1332
L +RE+ +L KA EE + E +++M +++L EQ E+ + L++
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 1333 --LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVS 1373
L +N L ++ ++ + +E + + L+ +V+ L+ VS
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Score = 71.2 bits (173), Expect = 6e-12
Identities = 185/885 (20%), Positives = 344/885 (38%), Gaps = 127/885 (14%)
Query: 352 EKVNLLELTWALDNELM-TVDS-AVQQAALACYHQELSYQQGQVEQLARERDKARQDLER 409
+K +L E AL EL T+D+ A QQ QE++ + +E+ + + QD+ +
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 410 AEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQR 469
LE + E + + EK + LE +E L EV+ +++ E H+ R
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE----LACEVKVLQQVKAESEHK-R 1254
Query: 470 AALEWDVGRLQAEEA-GLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKD---L 525
L+ V L A+ + G R ++ LA K S+LQ E+ V L ++E+ +K KD L
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKA-SKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 526 EFVLKDK---LEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKN 582
E L+D L+ ++ + L R L+E + ++ Q+ +E + LE L
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQ-LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 583 RHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELM------MEQVKEHYQDLRTQL 636
D + L A L ++ +S E +E+ K Q L
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 637 ETKVNYYEREIAALKRNFEKERKDMEQ--ARRREVSVLEGQKADLEELHEKSQEVIWGLQ 694
+++ +R++A+ N EK++K +Q A + +S ++ D E
Sbjct: 1433 TVDLDH-QRQVAS---NLEKKQKKFDQLLAEEKSISARYAEERDRAEAE----------- 1477
Query: 695 EQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPAR 754
AR E + + LA +AL EA+ E +
Sbjct: 1478 ------AREKETKALSLARALEEAL----------------EAKEEFERQ---------N 1506
Query: 755 RDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARG 814
+ L ++E+ G E + +RAL+ Q E R Q L E+EL+
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ--VEEMRTQ----LEELEDELQATED 1560
Query: 815 KRVDGPSLEAEMQALP----KDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESE 870
++ LE MQA+ +D E + LL + E L + +
Sbjct: 1561 AKL---RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL------EDERKQ 1611
Query: 871 EAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEP-----EP 925
A +++ D + ++ A A ++ ++Q D +E E
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 926 FGASAAGLEQPGARELPLLGTERD-ASQTQPRMWEPPLRP--AASCRGQAERLQAIQEER 982
F S ++ + E +L + + AS + R R A A A+ +E+
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 983 ARSWSRGTQ--EQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLA 1040
R +R Q E+ E+Q+ E L K +++V + +LA E+ A
Sbjct: 1732 RRLEARIAQLEEELEEEQSNME-LLNDRFRKTTLQVDTLNA-----ELA------AERSA 1779
Query: 1041 APEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDL 1100
A + + LER+ +++ KL LE V++ + + L+ +
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKS----------------KFKATISALEAKI 1823
Query: 1101 GRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLG 1160
G++ ++LE A K + +K ++ ++E R YK+Q+ + N R+ QL
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 1161 QEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVEL 1205
++ + + + + L + L++ + + S ++ L+ L
Sbjct: 1884 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928
Score = 69.3 bits (168), Expect = 2e-11
Identities = 93/419 (22%), Positives = 180/419 (42%), Gaps = 40/419 (9%)
Query: 972 AERLQAIQE-----ERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHL 1026
AE+LQA E E R+ +++ E E +E ++ + + + +H+
Sbjct: 893 AEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 1027 QLADPQGSWQEQLAAPEEGETKIALEREKDD-----METKLLHLEDVVRALEKHVDLREN 1081
Q +EQL E K+ LE+ + ME ++L LED K L E+
Sbjct: 953 Q------DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 1082 DRLEFH-RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNR 1140
E +L+EE KN L ++R + E S + + K+ E +++ EKA + L+
Sbjct: 1007 RIAECSSQLAEEEEKAKN-LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK---LDG 1062
Query: 1141 QNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK 1200
+ + +DQ+++L ++ +L + + + + + T ++ ++ QI +
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 1201 LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVA 1260
L+ + E + +L++ LE + +++ L AQ QE+R + VA
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT---LDTTAAQ--QELRTKREQEVA 1177
Query: 1261 ELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF 1320
EL + L + + ++ R+ H L+ E++E+A+ N+E K K+
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE--------KNKQGL 1229
Query: 1321 EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAA 1379
E + KEL E L + +E K++ + Q + L KV ++L +A A
Sbjct: 1230 ETDN------KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Score = 59.3 bits (142), Expect = 2e-08
Identities = 119/578 (20%), Positives = 240/578 (41%), Gaps = 74/578 (12%)
Query: 156 EEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQ--IRGVWEELGVGSS 213
E+ ES K ++N+ + + L SE+ + + + DT +Q +R E+
Sbjct: 1125 EDFESEKASRNKAEKQKRDL----SEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 214 GHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLES 273
L E+ Q ++ LE+L +L+Q K +LE+ + GL + L E
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 274 STRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQ 333
QV ES + V L + + +G A Q
Sbjct: 1241 KVL---------QQVKAESEHKRKKLDAQVQ-----ELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 334 EGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAA-----LACYHQELSY 388
+ N +L+ + + + + +L+++L +Q+ L+ ++L
Sbjct: 1287 NELDNVSTLLEEAE---KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 389 QQGQVEQLARERDKARQDLERA----EKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYR 444
++ +++ E ++AR++LE+ + + + K++DD T+E L E K K L+
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA-- 1401
Query: 445 ERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEI 504
L +E E+ L +++ LE RLQ E L L + S L+K+
Sbjct: 1402 ---EALSQRLE-EKALAYDK-------LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450
Query: 505 VEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDR 564
+ + L++ + ++ + ++ +D+ E ++ E + A L+E + + +
Sbjct: 1451 KKFDQLLAEEKSISARYAEE-----RDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505
Query: 565 NDELQAELEGLWA----------RLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPV 614
N +L+A++E L + L K++ + + R QL L L +
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE----LQATEDA 1561
Query: 615 SIETELMMEQVKEHYQ-DLRT---QLETKVNYYEREIAALKRNFEKERKD--MEQARRRE 668
+ E+ M+ +K ++ DL+T Q E K +++ L+ E ERK + A +++
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621
Query: 669 VSV-LEGQKADLEELHEKSQEVI---WGLQEQLQDTAR 702
+ + L+ +A +E ++ EVI LQ Q++D R
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Score = 39.7 bits (91), Expect = 0.020
Identities = 50/226 (22%), Positives = 96/226 (42%), Gaps = 18/226 (7%)
Query: 376 QAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHST--LEQLTE 433
+A +A +EL +Q +E L D+ R+ + + N E E + Q E
Sbjct: 1735 EARIAQLEEELEEEQSNMELL---NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 434 KKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLA 493
++ K L+ +E ++S+ +A +ALE +G+L+ + ++ A
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATI-----------SALEAKIGQLEEQLEQEAKERAAA 1840
Query: 494 LKENSRLQKEIVEVVEKLSDSERLALKLQKDLE--FVLKDKLEPQSAELLAQEERFAAVL 551
K R +K++ E+ ++ D R A + ++ +E +L+ Q E + R A
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 552 KEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
++ + + D + N+ L E+ L RL + S RRQL
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQL 1946
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 96.3 bits (238), Expect = 2e-19
Identities = 228/1108 (20%), Positives = 437/1108 (39%), Gaps = 189/1108 (17%)
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q E++ + D+ ++ ER +K E +KE++ HS QLTE+K +LL+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENE-LKELEQKHS---QLTEEK------------NLLQ 893
Query: 452 SEVEAERELFWE--QAHRQRAALEWDVGRLQAE-EAGLREKLTLALK---ENSRLQKEIV 505
+++AE EL+ E + + AA + ++ + E EA L E+ + E ++ ++++
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 506 EVVEKLSDSERLALKLQ----------KDLE---FVLKDKLEPQSAELLAQEERFAAV-- 550
++ E+L + E KLQ K LE V+ D+ S E EER + +
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 551 -LKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLG 609
L E E K ++L ++ ++ + L RL K S + +R+L G +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIA 1072
Query: 610 NSAPVSIETELMMEQVKEHYQDLRTQLET----------KVNYYEREIAALKRNFEKERK 659
+ E ++ + + +E Q +L+ K+ E I+ L+ + + ER
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 660 DMEQARRREVSV---LEGQKADLE----------ELHEKSQEVIWGLQEQLQDTARGPEP 706
+A +++ + LE K +LE EL K ++ + L++ L + R E
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 707 EQMGLAPCCTQALCGLALRHHSHLQQIRR-------------EAEAELSGELSGLGALPA 753
+ + QA+ L L+Q +R + A+L+GEL LG
Sbjct: 1193 QVQEMRQKHAQAVEELT----EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 754 -----RRDLTLELEEPPQGPLPRGSQRSE--------QLELE-----------RALKLQP 789
++ L +++E R+E Q E+E +A+KL
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 790 CASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPK---DGLVAGSGQEGTRGL 846
+ +Q+ + L +EE LE E +L + + A E
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 847 LPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERW 906
L ++ ++ L D + EA G +R Q + TQ A ++ E+
Sbjct: 1369 LNIQLSDSKKKLQ-----DFASTVEALEEGKKRFQKEIENLTQQYEEKAA--AYDKLEKT 1421
Query: 907 SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAA 966
+D +V + + + LE+ + LL E++ S A
Sbjct: 1422 KNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFDQLLAEEKNISSKY-----------A 1468
Query: 967 SCRGQAERLQAIQEERARSWSRGTQE--QASEQQARAEGALEPGCHKHSVEVARRGSLPS 1024
R +AE +E +A S +R +E +A E+ R L + +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML-------------KAEMED 1515
Query: 1025 HLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA------------- 1071
+ D G +L ++K ALE + ++M+T+L LED ++A
Sbjct: 1516 LVSSKDDVGKNVHELE-----KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 1072 ---------LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIE 1122
L+ + E R + R E D + R AA+ + K++E
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 1123 VLK----KDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
+ K +E+A ++ L Q ++++ +L ++ A ++ + + +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 1179 MLTQSLEEVVRSGQQQSDQIQKLRVEL-------ECLNQEHQSLQLPWSELTQTLEESQD 1231
L + L R+ +Q + ++L EL L E + L+ ++L + LEE Q
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 1232 QVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKAT 1291
++ R+R+A Q+ + + E R + + E AR++L+ Q +E +L
Sbjct: 1751 NMEAMSDRVRKA----TQQAEQLSNELATE--RSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 1292 EERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK-SDLLLKELYVENAHLVRALQATEEK 1350
E V+ K+ L+ K+ +L+EQ E+ + K L ++ L L E++
Sbjct: 1805 EGAVKSK---FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 1351 QRGAEKQSRLLEEKVRALNKLVSRIAPA 1378
++ AE+ E+ + +L ++ A
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Score = 78.6 bits (192), Expect = 4e-14
Identities = 174/877 (19%), Positives = 346/877 (39%), Gaps = 101/877 (11%)
Query: 352 EKVNLLELTWALDNELM-TVDS-AVQQAALACYHQELSYQQGQVEQLARERDKARQDLER 409
+K +L E AL EL T+DS A QQ A QE++ + +++ R + Q++ +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 410 AEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQR 469
+ +E + E + + +K + LE+ + LR +A++E+ ++
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKK 1254
Query: 470 AALEWDVGRLQAE-EAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV 528
LE V LQ++ G R + L K + +LQ E+ V L+++E A+KL KD+ +
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 529 LKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAEL-EGLWARLPKNRHSPS 587
+ Q ELL +E R K R L++ + LQ +L E + A+ RH +
Sbjct: 1314 SSQLQDTQ--ELLQEETRQKL---NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 588 WSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREI 647
+ L +S + +E ++E + + ++E YE +
Sbjct: 1369 LNIQ----------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 648 AALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPE 707
AA + EK + ++Q V L+ Q+ + L +K ++ L E+ +++ +
Sbjct: 1413 AAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 708 QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQG 767
A + L+L + + EA+ EL + L E+E+
Sbjct: 1472 DRAEAEAREKETKALSL---ARALEEALEAKEELE---------RTNKMLKAEMEDLVSS 1519
Query: 768 PLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQ 827
G E + +RAL+ Q +M L E+EL+ ++ LE MQ
Sbjct: 1520 KDDVGKNVHELEKSKRALETQ------MEEMKTQLEELEDELQATEDAKL---RLEVNMQ 1570
Query: 828 AL----PKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQ 883
AL +D E R L + E L + + A A +++
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------EDERKQRALAAAAKKKLEG 1624
Query: 884 DTEATQSPAPAPAPASHGPSERWSRMQPCGVD-----GDIVPKEPEPFGASAAGLEQPGA 938
D + + A + ++ ++Q D D E F + ++ +
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 939 RELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERL---QAIQEERARSWSRGTQ--EQ 993
E L+ + D + + + L A L A+Q+E+ R +R Q E+
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 994 ASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
E+Q E A+ K + + + + +LA + + Q+ +A ++ LER
Sbjct: 1745 LEEEQGNME-AMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQ------LER 1792
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
+ ++ +KL +E V++ + L+ + ++ +++E
Sbjct: 1793 QNKELRSKLHEMEGAVKS----------------KFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
A K ++ K ++ ++E + + YK+Q + N RV QL ++ + +++
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQ 1210
+ L + L+E S + ++ L+ +L N+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 72.4 bits (176), Expect = 3e-12
Identities = 90/424 (21%), Positives = 198/424 (46%), Gaps = 53/424 (12%)
Query: 962 LRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGS 1021
++P Q E +QA ++E ++ E+Q +AE L+ KHS
Sbjct: 841 VKPLLQVTRQEEEMQAKEDEL---------QKTKERQQKAENELKELEQKHS-------- 883
Query: 1022 LPSHLQLADPQGSWQEQLAA-----PEEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QL + + QEQL A E E ++ L +K ++E ++LH ++ LE+
Sbjct: 884 -----QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILH--EMEARLEEEE 935
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGR---VRQELEAAESTHDAQRKEI--EVLKKDKEKA 1131
D + + E +++++ L+ L RQ+L+ + T +A+ K++ E+L D +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN- 994
Query: 1132 CSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSG 1191
L+++ + ++++S L + + ++A +H I L L++ +S
Sbjct: 995 ----NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 1192 QQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH---L 1248
Q+ +KL + +++ LQ +EL L + ++++Q A RL AQ L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 1249 QEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVE---EAEMILKNM 1305
+++R + + +++L L + AR + + Q+ + ++L+A + +E ++ + +
Sbjct: 1111 KKIREL-EGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 1306 EMLLQEKVDKLKEQFEKNTKS-DLLLKELYVENAHLVRALQATEEKQRGA----EKQSRL 1360
+++V LK+ ++ T+S + ++E+ ++A V L E+ + A +K +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 1361 LEEK 1364
LE++
Sbjct: 1229 LEKE 1232
Score = 71.2 bits (173), Expect = 6e-12
Identities = 195/969 (20%), Positives = 362/969 (37%), Gaps = 188/969 (19%)
Query: 476 VGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSD--SERLALKLQKDLEFVLKDKL 533
V R + E ++L + + + E+ E+ +K S E+ L+ Q E L +
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 534 EPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGR 593
E L A+++ +L E E + + +DR +LQAE + + ++ R
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 594 RR----------QLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLE-----T 638
++ ++ L + + +S E +L+ E++ + +L + E T
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 639 KV-NYYEREIAALK---RNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQ 694
K+ N +E I+ L+ + EK R+++E+ +R+ LEG +D E Q I L+
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRK----LEGDASDFHEQIADLQAQIAELK 1082
Query: 695 EQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPAR 754
QL A+ E Q LA L + ++ L++IR EL G +S L
Sbjct: 1083 MQL---AKKEEELQAALA-----RLDDEIAQKNNALKKIR-----ELEGHISDL------ 1123
Query: 755 RDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARG 814
E L+ ERA A K + L E E L+
Sbjct: 1124 ---------------------QEDLDSERA------ARNKAEKQKRDLGEELEALKTELE 1156
Query: 815 KRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAG 874
+D + + E++A + E + A + S EA
Sbjct: 1157 DTLDSTATQQELRAKREQ----------------------EVTVLKKALDEETRSHEAQV 1194
Query: 875 AGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLE 934
R++ AQ E +E+ + + + D + E A AG
Sbjct: 1195 QEMRQKHAQAVEEL--------------TEQLEQFKRAKANLDKNKQTLEKENADLAG-- 1238
Query: 935 QPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQA 994
EL +LG + + + + E ++ S ER +A ++ + E
Sbjct: 1239 -----ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESV 1292
Query: 995 SEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKI-ALER 1053
+ AEG K + +VA S QL D Q QE+ TK+ LE
Sbjct: 1293 TGMLNEAEGK----AIKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDL----RENDRLEFHRLSEENTLLKNDLGRVRQELEA 1109
E++ ++ +L + + LE+H+ + + + + L+ R ++E+E
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 1110 AESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ-------- 1161
++ + + L+K K + E++ L N + +S L + + Q
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 1162 ------EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC-------- 1207
E +A+ E L ++LEE + + ++ + L+ E+E
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 1208 ------LNQEHQSLQLPWSELTQTLEESQDQVQG---AHLRLRQAQAQHLQEVRLVPQDR 1258
L + ++L+ E+ LEE +D++Q A LRL EV + Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL---------EVNM--QAL 1572
Query: 1259 VAELHRLLSLQGEQ-ARRRLDAQREEHEKQLKATEERVEEA---------EMILKNMEML 1308
+ R L + EQ +R QR+ HE + + +ER + A E LK++E+
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 1309 LQEKVDKLKEQFEKNTKSDLLLKELY--VENAHLVR-----ALQATEEKQRGAEKQSRLL 1361
+ +E ++ K +K+ +E+A R + E+K + E L
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1362 EEKVRALNK 1370
+E + A +
Sbjct: 1693 QEDLAAAER 1701
Score = 66.2 bits (160), Expect = 2e-10
Identities = 68/328 (20%), Positives = 149/328 (45%), Gaps = 29/328 (8%)
Query: 1049 IALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHR----LSEENTLLKNDLGRVR 1104
+ + R++++M+ K ED ++ ++ EN+ E + L+EE LL+ L
Sbjct: 845 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 1105 QELEAAESTH---DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+ AE A+++E+E + + E E E +Q Q + +++Q + + + +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSE 1221
E + + + +VT + + LE+ + Q++++ K E + L+ S+
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----------ERKLLEERISD 1010
Query: 1222 LTQTLEESQDQVQG-AHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQ 1280
LT L E +++ + L+ + EVRL +++ + + E+ +R+L+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-------ELEKLKRKLEGD 1063
Query: 1281 REEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHL 1340
+ +Q+ + ++ E +M L E LQ + +L ++ + + ++EL + L
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 1341 VRALQATEEKQRGAEKQSRLLEEKVRAL 1368
L + + AEKQ R L E++ AL
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEAL 1151
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/285 (21%), Positives = 123/285 (43%), Gaps = 16/285 (5%)
Query: 1102 RVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+V+ L+ + Q KE E L+K KE+ L Q + + N+ QL
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ----QQSDQIQKLRVELECLNQEHQSLQL 1217
E + A+ EE RV + Q LEE++ + ++ D+ Q+L+ E + + Q+ L+
Sbjct: 899 ETELY-AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 1218 PWSELTQTLEESQDQVQGAHLRLRQA---------QAQHLQEVRLVPQDRVAELHRLLSL 1268
E ++ Q + A ++++ Q L + R + ++R+++L L+
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 1269 QGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDL 1328
+ E+A+ L + +HE + E R+++ E + +E L ++ + E+
Sbjct: 1018 EEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 1329 LLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVS 1373
+ EL ++ A LQA + Q +K+R L +S
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
Score = 45.8 bits (107), Expect = 3e-04
Identities = 55/227 (24%), Positives = 103/227 (45%), Gaps = 23/227 (10%)
Query: 376 QAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKK 435
+A +A +EL +QG +E ++ D+ R+ ++AE+ + E E + Q E
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMS---DRVRKATQQAEQLSNELATE-----RSTAQKNESA 1786
Query: 436 IKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ---AEEAGLREKLTL 492
+ LE+ +E S L A + F AALE + +L+ +EA ++ T
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTI----AALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 493 ALKENSRLQKEIVEVVEKLSDSERLA--LKLQKDLEFVLKDKLEPQSAELLAQEERFAAV 550
+LK+ + KEI+ VE D ++A K Q + +L+ Q E + +R A
Sbjct: 1843 SLKQKDKKLKEILLQVE---DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 551 LKEYELKCRDLQDRNDELQAELEGLWARLPKNRHS---PSWSPDGRR 594
++ + + + + N+ + E+ L ++L + + PS GRR
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRR 1946
Score = 42.7 bits (99), Expect = 0.002
Identities = 44/158 (27%), Positives = 75/158 (47%), Gaps = 10/158 (6%)
Query: 363 LDNELMTVDSAVQ---QAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK 419
L ++L ++ AV+ ++ +A +++ + QVEQ ARE+ A + L++ +K+ E +
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 420 EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRL 479
+++D EQ E+ E+G L R EAE E A+R++ E D
Sbjct: 1857 QVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-T 1911
Query: 480 QAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERL 517
++ EA RE ALK R E V + S R+
Sbjct: 1912 ESNEAMGRE--VNALKSKLRRGNETSFVPSRRSGGRRV 1947
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 96.3 bits (238), Expect = 2e-19
Identities = 228/1108 (20%), Positives = 437/1108 (39%), Gaps = 189/1108 (17%)
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q E++ + D+ ++ ER +K E +KE++ HS QLTE+K +LL+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENE-LKELEQKHS---QLTEEK------------NLLQ 900
Query: 452 SEVEAERELFWE--QAHRQRAALEWDVGRLQAE-EAGLREKLTLALK---ENSRLQKEIV 505
+++AE EL+ E + + AA + ++ + E EA L E+ + E ++ ++++
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 506 EVVEKLSDSERLALKLQ----------KDLE---FVLKDKLEPQSAELLAQEERFAAV-- 550
++ E+L + E KLQ K LE V+ D+ S E EER + +
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 551 -LKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLG 609
L E E K ++L ++ ++ + L RL K S + +R+L G +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIA 1079
Query: 610 NSAPVSIETELMMEQVKEHYQDLRTQLET----------KVNYYEREIAALKRNFEKERK 659
+ E ++ + + +E Q +L+ K+ E I+ L+ + + ER
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 660 DMEQARRREVSV---LEGQKADLE----------ELHEKSQEVIWGLQEQLQDTARGPEP 706
+A +++ + LE K +LE EL K ++ + L++ L + R E
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 707 EQMGLAPCCTQALCGLALRHHSHLQQIRR-------------EAEAELSGELSGLGALPA 753
+ + QA+ L L+Q +R + A+L+GEL LG
Sbjct: 1200 QVQEMRQKHAQAVEELT----EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 754 -----RRDLTLELEEPPQGPLPRGSQRSE--------QLELE-----------RALKLQP 789
++ L +++E R+E Q E+E +A+KL
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 790 CASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPK---DGLVAGSGQEGTRGL 846
+ +Q+ + L +EE LE E +L + + A E
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 847 LPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERW 906
L ++ ++ L D + EA G +R Q + TQ A ++ E+
Sbjct: 1376 LNIQLSDSKKKLQ-----DFASTVEALEEGKKRFQKEIENLTQQYEEKAA--AYDKLEKT 1428
Query: 907 SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAA 966
+D +V + + + LE+ + LL E++ S A
Sbjct: 1429 KNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFDQLLAEEKNISSKY-----------A 1475
Query: 967 SCRGQAERLQAIQEERARSWSRGTQE--QASEQQARAEGALEPGCHKHSVEVARRGSLPS 1024
R +AE +E +A S +R +E +A E+ R L + +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML-------------KAEMED 1522
Query: 1025 HLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA------------- 1071
+ D G +L ++K ALE + ++M+T+L LED ++A
Sbjct: 1523 LVSSKDDVGKNVHELE-----KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 1072 ---------LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIE 1122
L+ + E R + R E D + R AA+ + K++E
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 1123 VLK----KDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
+ K +E+A ++ L Q ++++ +L ++ A ++ + + +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 1179 MLTQSLEEVVRSGQQQSDQIQKLRVEL-------ECLNQEHQSLQLPWSELTQTLEESQD 1231
L + L R+ +Q + ++L EL L E + L+ ++L + LEE Q
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 1232 QVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKAT 1291
++ R+R+A Q+ + + E R + + E AR++L+ Q +E +L
Sbjct: 1758 NMEAMSDRVRKA----TQQAEQLSNELATE--RSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 1292 EERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK-SDLLLKELYVENAHLVRALQATEEK 1350
E V+ K+ L+ K+ +L+EQ E+ + K L ++ L L E++
Sbjct: 1812 EGAVKSK---FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 1351 QRGAEKQSRLLEEKVRALNKLVSRIAPA 1378
++ AE+ E+ + +L ++ A
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Score = 78.6 bits (192), Expect = 4e-14
Identities = 174/877 (19%), Positives = 346/877 (39%), Gaps = 101/877 (11%)
Query: 352 EKVNLLELTWALDNELM-TVDS-AVQQAALACYHQELSYQQGQVEQLARERDKARQDLER 409
+K +L E AL EL T+DS A QQ A QE++ + +++ R + Q++ +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 410 AEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQR 469
+ +E + E + + +K + LE+ + LR +A++E+ ++
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKK 1261
Query: 470 AALEWDVGRLQAE-EAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV 528
LE V LQ++ G R + L K + +LQ E+ V L+++E A+KL KD+ +
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 529 LKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAEL-EGLWARLPKNRHSPS 587
+ Q ELL +E R K R L++ + LQ +L E + A+ RH +
Sbjct: 1321 SSQLQDTQ--ELLQEETRQKL---NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 588 WSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREI 647
+ L +S + +E ++E + + ++E YE +
Sbjct: 1376 LNIQ----------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 648 AALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPE 707
AA + EK + ++Q V L+ Q+ + L +K ++ L E+ +++ +
Sbjct: 1420 AAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 708 QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQG 767
A + L+L + + EA+ EL + L E+E+
Sbjct: 1479 DRAEAEAREKETKALSL---ARALEEALEAKEELE---------RTNKMLKAEMEDLVSS 1526
Query: 768 PLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQ 827
G E + +RAL+ Q +M L E+EL+ ++ LE MQ
Sbjct: 1527 KDDVGKNVHELEKSKRALETQ------MEEMKTQLEELEDELQATEDAKL---RLEVNMQ 1577
Query: 828 AL----PKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQ 883
AL +D E R L + E L + + A A +++
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------EDERKQRALAAAAKKKLEG 1631
Query: 884 DTEATQSPAPAPAPASHGPSERWSRMQPCGVD-----GDIVPKEPEPFGASAAGLEQPGA 938
D + + A + ++ ++Q D D E F + ++ +
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 939 RELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERL---QAIQEERARSWSRGTQ--EQ 993
E L+ + D + + + L A L A+Q+E+ R +R Q E+
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 994 ASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
E+Q E A+ K + + + + +LA + + Q+ +A ++ LER
Sbjct: 1752 LEEEQGNME-AMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQ------LER 1799
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
+ ++ +KL +E V++ + L+ + ++ +++E
Sbjct: 1800 QNKELRSKLHEMEGAVKS----------------KFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
A K ++ K ++ ++E + + YK+Q + N RV QL ++ + +++
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQ 1210
+ L + L+E S + ++ L+ +L N+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 72.4 bits (176), Expect = 3e-12
Identities = 90/424 (21%), Positives = 198/424 (46%), Gaps = 53/424 (12%)
Query: 962 LRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGS 1021
++P Q E +QA ++E ++ E+Q +AE L+ KHS
Sbjct: 848 VKPLLQVTRQEEEMQAKEDEL---------QKTKERQQKAENELKELEQKHS-------- 890
Query: 1022 LPSHLQLADPQGSWQEQLAA-----PEEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QL + + QEQL A E E ++ L +K ++E ++LH ++ LE+
Sbjct: 891 -----QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILH--EMEARLEEEE 942
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGR---VRQELEAAESTHDAQRKEI--EVLKKDKEKA 1131
D + + E +++++ L+ L RQ+L+ + T +A+ K++ E+L D +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN- 1001
Query: 1132 CSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSG 1191
L+++ + ++++S L + + ++A +H I L L++ +S
Sbjct: 1002 ----NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 1192 QQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH---L 1248
Q+ +KL + +++ LQ +EL L + ++++Q A RL AQ L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 1249 QEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVE---EAEMILKNM 1305
+++R + + +++L L + AR + + Q+ + ++L+A + +E ++ + +
Sbjct: 1118 KKIREL-EGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 1306 EMLLQEKVDKLKEQFEKNTKS-DLLLKELYVENAHLVRALQATEEKQRGA----EKQSRL 1360
+++V LK+ ++ T+S + ++E+ ++A V L E+ + A +K +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 1361 LEEK 1364
LE++
Sbjct: 1236 LEKE 1239
Score = 71.2 bits (173), Expect = 6e-12
Identities = 195/969 (20%), Positives = 362/969 (37%), Gaps = 188/969 (19%)
Query: 476 VGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSD--SERLALKLQKDLEFVLKDKL 533
V R + E ++L + + + E+ E+ +K S E+ L+ Q E L +
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 534 EPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGR 593
E L A+++ +L E E + + +DR +LQAE + + ++ R
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 594 RR----------QLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLE-----T 638
++ ++ L + + +S E +L+ E++ + +L + E T
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 639 KV-NYYEREIAALK---RNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQ 694
K+ N +E I+ L+ + EK R+++E+ +R+ LEG +D E Q I L+
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRK----LEGDASDFHEQIADLQAQIAELK 1089
Query: 695 EQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPAR 754
QL A+ E Q LA L + ++ L++IR EL G +S L
Sbjct: 1090 MQL---AKKEEELQAALA-----RLDDEIAQKNNALKKIR-----ELEGHISDL------ 1130
Query: 755 RDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARG 814
E L+ ERA A K + L E E L+
Sbjct: 1131 ---------------------QEDLDSERA------ARNKAEKQKRDLGEELEALKTELE 1163
Query: 815 KRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAG 874
+D + + E++A + E + A + S EA
Sbjct: 1164 DTLDSTATQQELRAKREQ----------------------EVTVLKKALDEETRSHEAQV 1201
Query: 875 AGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLE 934
R++ AQ E +E+ + + + D + E A AG
Sbjct: 1202 QEMRQKHAQAVEEL--------------TEQLEQFKRAKANLDKNKQTLEKENADLAG-- 1245
Query: 935 QPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQA 994
EL +LG + + + + E ++ S ER +A ++ + E
Sbjct: 1246 -----ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESV 1299
Query: 995 SEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKI-ALER 1053
+ AEG K + +VA S QL D Q QE+ TK+ LE
Sbjct: 1300 TGMLNEAEGK----AIKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDL----RENDRLEFHRLSEENTLLKNDLGRVRQELEA 1109
E++ ++ +L + + LE+H+ + + + + L+ R ++E+E
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 1110 AESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ-------- 1161
++ + + L+K K + E++ L N + +S L + + Q
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 1162 ------EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC-------- 1207
E +A+ E L ++LEE + + ++ + L+ E+E
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 1208 ------LNQEHQSLQLPWSELTQTLEESQDQVQG---AHLRLRQAQAQHLQEVRLVPQDR 1258
L + ++L+ E+ LEE +D++Q A LRL EV + Q
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL---------EVNM--QAL 1579
Query: 1259 VAELHRLLSLQGEQ-ARRRLDAQREEHEKQLKATEERVEEA---------EMILKNMEML 1308
+ R L + EQ +R QR+ HE + + +ER + A E LK++E+
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 1309 LQEKVDKLKEQFEKNTKSDLLLKELY--VENAHLVR-----ALQATEEKQRGAEKQSRLL 1361
+ +E ++ K +K+ +E+A R + E+K + E L
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1362 EEKVRALNK 1370
+E + A +
Sbjct: 1700 QEDLAAAER 1708
Score = 66.2 bits (160), Expect = 2e-10
Identities = 68/328 (20%), Positives = 149/328 (45%), Gaps = 29/328 (8%)
Query: 1049 IALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHR----LSEENTLLKNDLGRVR 1104
+ + R++++M+ K ED ++ ++ EN+ E + L+EE LL+ L
Sbjct: 852 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 1105 QELEAAESTH---DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+ AE A+++E+E + + E E E +Q Q + +++Q + + + +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSE 1221
E + + + +VT + + LE+ + Q++++ K E + L+ S+
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----------ERKLLEERISD 1017
Query: 1222 LTQTLEESQDQVQG-AHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQ 1280
LT L E +++ + L+ + EVRL +++ + + E+ +R+L+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-------ELEKLKRKLEGD 1070
Query: 1281 REEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHL 1340
+ +Q+ + ++ E +M L E LQ + +L ++ + + ++EL + L
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 1341 VRALQATEEKQRGAEKQSRLLEEKVRAL 1368
L + + AEKQ R L E++ AL
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEAL 1158
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/285 (21%), Positives = 123/285 (43%), Gaps = 16/285 (5%)
Query: 1102 RVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+V+ L+ + Q KE E L+K KE+ L Q + + N+ QL
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ----QQSDQIQKLRVELECLNQEHQSLQL 1217
E + A+ EE RV + Q LEE++ + ++ D+ Q+L+ E + + Q+ L+
Sbjct: 906 ETELY-AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 1218 PWSELTQTLEESQDQVQGAHLRLRQA---------QAQHLQEVRLVPQDRVAELHRLLSL 1268
E ++ Q + A ++++ Q L + R + ++R+++L L+
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 1269 QGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDL 1328
+ E+A+ L + +HE + E R+++ E + +E L ++ + E+
Sbjct: 1025 EEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 1329 LLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVS 1373
+ EL ++ A LQA + Q +K+R L +S
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
Score = 45.8 bits (107), Expect = 3e-04
Identities = 55/227 (24%), Positives = 103/227 (45%), Gaps = 23/227 (10%)
Query: 376 QAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKK 435
+A +A +EL +QG +E ++ D+ R+ ++AE+ + E E + Q E
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMS---DRVRKATQQAEQLSNELATE-----RSTAQKNESA 1793
Query: 436 IKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ---AEEAGLREKLTL 492
+ LE+ +E S L A + F AALE + +L+ +EA ++ T
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTI----AALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 493 ALKENSRLQKEIVEVVEKLSDSERLA--LKLQKDLEFVLKDKLEPQSAELLAQEERFAAV 550
+LK+ + KEI+ VE D ++A K Q + +L+ Q E + +R A
Sbjct: 1850 SLKQKDKKLKEILLQVE---DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 551 LKEYELKCRDLQDRNDELQAELEGLWARLPKNRHS---PSWSPDGRR 594
++ + + + + N+ + E+ L ++L + + PS GRR
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRR 1953
Score = 42.7 bits (99), Expect = 0.002
Identities = 44/158 (27%), Positives = 75/158 (47%), Gaps = 10/158 (6%)
Query: 363 LDNELMTVDSAVQ---QAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVK 419
L ++L ++ AV+ ++ +A +++ + QVEQ ARE+ A + L++ +K+ E +
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 420 EMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRL 479
+++D EQ E+ E+G L R EAE E A+R++ E D
Sbjct: 1864 QVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-T 1918
Query: 480 QAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERL 517
++ EA RE ALK R E V + S R+
Sbjct: 1919 ESNEAMGRE--VNALKSKLRRGNETSFVPSRRSGGRRV 1954
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 96.3 bits (238), Expect = 2e-19
Identities = 228/1108 (20%), Positives = 437/1108 (39%), Gaps = 189/1108 (17%)
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q E++ + D+ ++ ER +K E +KE++ HS QLTE+K +LL+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENE-LKELEQKHS---QLTEEK------------NLLQ 900
Query: 452 SEVEAERELFWE--QAHRQRAALEWDVGRLQAE-EAGLREKLTLALK---ENSRLQKEIV 505
+++AE EL+ E + + AA + ++ + E EA L E+ + E ++ ++++
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 506 EVVEKLSDSERLALKLQ----------KDLE---FVLKDKLEPQSAELLAQEERFAAV-- 550
++ E+L + E KLQ K LE V+ D+ S E EER + +
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 551 -LKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLG 609
L E E K ++L ++ ++ + L RL K S + +R+L G +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIA 1079
Query: 610 NSAPVSIETELMMEQVKEHYQDLRTQLET----------KVNYYEREIAALKRNFEKERK 659
+ E ++ + + +E Q +L+ K+ E I+ L+ + + ER
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 660 DMEQARRREVSV---LEGQKADLE----------ELHEKSQEVIWGLQEQLQDTARGPEP 706
+A +++ + LE K +LE EL K ++ + L++ L + R E
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 707 EQMGLAPCCTQALCGLALRHHSHLQQIRR-------------EAEAELSGELSGLGALPA 753
+ + QA+ L L+Q +R + A+L+GEL LG
Sbjct: 1200 QVQEMRQKHAQAVEELT----EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 754 -----RRDLTLELEEPPQGPLPRGSQRSE--------QLELE-----------RALKLQP 789
++ L +++E R+E Q E+E +A+KL
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 790 CASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPK---DGLVAGSGQEGTRGL 846
+ +Q+ + L +EE LE E +L + + A E
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 847 LPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERW 906
L ++ ++ L D + EA G +R Q + TQ A ++ E+
Sbjct: 1376 LNIQLSDSKKKLQ-----DFASTVEALEEGKKRFQKEIENLTQQYEEKAA--AYDKLEKT 1428
Query: 907 SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAA 966
+D +V + + + LE+ + LL E++ S A
Sbjct: 1429 KNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFDQLLAEEKNISSKY-----------A 1475
Query: 967 SCRGQAERLQAIQEERARSWSRGTQE--QASEQQARAEGALEPGCHKHSVEVARRGSLPS 1024
R +AE +E +A S +R +E +A E+ R L + +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML-------------KAEMED 1522
Query: 1025 HLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA------------- 1071
+ D G +L ++K ALE + ++M+T+L LED ++A
Sbjct: 1523 LVSSKDDVGKNVHELE-----KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 1072 ---------LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIE 1122
L+ + E R + R E D + R AA+ + K++E
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 1123 VLK----KDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
+ K +E+A ++ L Q ++++ +L ++ A ++ + + +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 1179 MLTQSLEEVVRSGQQQSDQIQKLRVEL-------ECLNQEHQSLQLPWSELTQTLEESQD 1231
L + L R+ +Q + ++L EL L E + L+ ++L + LEE Q
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 1232 QVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKAT 1291
++ R+R+A Q+ + + E R + + E AR++L+ Q +E +L
Sbjct: 1758 NMEAMSDRVRKA----TQQAEQLSNELATE--RSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 1292 EERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK-SDLLLKELYVENAHLVRALQATEEK 1350
E V+ K+ L+ K+ +L+EQ E+ + K L ++ L L E++
Sbjct: 1812 EGAVKSK---FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Query: 1351 QRGAEKQSRLLEEKVRALNKLVSRIAPA 1378
++ AE+ E+ + +L ++ A
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Score = 78.2 bits (191), Expect = 5e-14
Identities = 173/872 (19%), Positives = 344/872 (39%), Gaps = 101/872 (11%)
Query: 352 EKVNLLELTWALDNELM-TVDS-AVQQAALACYHQELSYQQGQVEQLARERDKARQDLER 409
+K +L E AL EL T+DS A QQ A QE++ + +++ R + Q++ +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 410 AEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQR 469
+ +E + E + + +K + LE+ + LR +A++E+ ++
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKK 1261
Query: 470 AALEWDVGRLQAE-EAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV 528
LE V LQ++ G R + L K + +LQ E+ V L+++E A+KL KD+ +
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 529 LKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAEL-EGLWARLPKNRHSPS 587
+ Q ELL +E R K R L++ + LQ +L E + A+ RH +
Sbjct: 1321 SSQLQDTQ--ELLQEETRQKL---NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 588 WSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREI 647
+ L +S + +E ++E + + ++E YE +
Sbjct: 1376 LNIQ----------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 648 AALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPE 707
AA + EK + ++Q V L+ Q+ + L +K ++ L E+ +++ +
Sbjct: 1420 AAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 708 QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQG 767
A + L+L + + EA+ EL + L E+E+
Sbjct: 1479 DRAEAEAREKETKALSL---ARALEEALEAKEELE---------RTNKMLKAEMEDLVSS 1526
Query: 768 PLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQ 827
G E + +RAL+ Q +M L E+EL+ ++ LE MQ
Sbjct: 1527 KDDVGKNVHELEKSKRALETQ------MEEMKTQLEELEDELQATEDAKL---RLEVNMQ 1577
Query: 828 AL----PKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQ 883
AL +D E R L + E L + + A A +++
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------EDERKQRALAAAAKKKLEG 1631
Query: 884 DTEATQSPAPAPAPASHGPSERWSRMQPCGVD-----GDIVPKEPEPFGASAAGLEQPGA 938
D + + A + ++ ++Q D D E F + ++ +
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Query: 939 RELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERL---QAIQEERARSWSRGTQ--EQ 993
E L+ + D + + + L A L A+Q+E+ R +R Q E+
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 994 ASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
E+Q E A+ K + + + + +LA + + Q+ +A ++ LER
Sbjct: 1752 LEEEQGNME-AMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQ------LER 1799
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
+ ++ +KL +E V++ + L+ + ++ +++E
Sbjct: 1800 QNKELRSKLHEMEGAVKS----------------KFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
A K ++ K ++ ++E + + YK+Q + N RV QL ++ + +++
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVEL 1205
+ L + L+E S + ++ L+ +L
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 72.4 bits (176), Expect = 3e-12
Identities = 90/424 (21%), Positives = 198/424 (46%), Gaps = 53/424 (12%)
Query: 962 LRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGS 1021
++P Q E +QA ++E ++ E+Q +AE L+ KHS
Sbjct: 848 VKPLLQVTRQEEEMQAKEDEL---------QKTKERQQKAENELKELEQKHS-------- 890
Query: 1022 LPSHLQLADPQGSWQEQLAA-----PEEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QL + + QEQL A E E ++ L +K ++E ++LH ++ LE+
Sbjct: 891 -----QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILH--EMEARLEEEE 942
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGR---VRQELEAAESTHDAQRKEI--EVLKKDKEKA 1131
D + + E +++++ L+ L RQ+L+ + T +A+ K++ E+L D +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN- 1001
Query: 1132 CSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSG 1191
L+++ + ++++S L + + ++A +H I L L++ +S
Sbjct: 1002 ----NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 1192 QQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH---L 1248
Q+ +KL + +++ LQ +EL L + ++++Q A RL AQ L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 1249 QEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVE---EAEMILKNM 1305
+++R + + +++L L + AR + + Q+ + ++L+A + +E ++ + +
Sbjct: 1118 KKIREL-EGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 1306 EMLLQEKVDKLKEQFEKNTKS-DLLLKELYVENAHLVRALQATEEKQRGA----EKQSRL 1360
+++V LK+ ++ T+S + ++E+ ++A V L E+ + A +K +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 1361 LEEK 1364
LE++
Sbjct: 1236 LEKE 1239
Score = 71.2 bits (173), Expect = 6e-12
Identities = 195/969 (20%), Positives = 362/969 (37%), Gaps = 188/969 (19%)
Query: 476 VGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSD--SERLALKLQKDLEFVLKDKL 533
V R + E ++L + + + E+ E+ +K S E+ L+ Q E L +
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 534 EPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGR 593
E L A+++ +L E E + + +DR +LQAE + + ++ R
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 594 RR----------QLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLE-----T 638
++ ++ L + + +S E +L+ E++ + +L + E T
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 639 KV-NYYEREIAALK---RNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQ 694
K+ N +E I+ L+ + EK R+++E+ +R+ LEG +D E Q I L+
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRK----LEGDASDFHEQIADLQAQIAELK 1089
Query: 695 EQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPAR 754
QL A+ E Q LA L + ++ L++IR EL G +S L
Sbjct: 1090 MQL---AKKEEELQAALA-----RLDDEIAQKNNALKKIR-----ELEGHISDL------ 1130
Query: 755 RDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARG 814
E L+ ERA A K + L E E L+
Sbjct: 1131 ---------------------QEDLDSERA------ARNKAEKQKRDLGEELEALKTELE 1163
Query: 815 KRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAG 874
+D + + E++A + E + A + S EA
Sbjct: 1164 DTLDSTATQQELRAKREQ----------------------EVTVLKKALDEETRSHEAQV 1201
Query: 875 AGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLE 934
R++ AQ E +E+ + + + D + E A AG
Sbjct: 1202 QEMRQKHAQAVEEL--------------TEQLEQFKRAKANLDKNKQTLEKENADLAG-- 1245
Query: 935 QPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQA 994
EL +LG + + + + E ++ S ER +A ++ + E
Sbjct: 1246 -----ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESV 1299
Query: 995 SEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKI-ALER 1053
+ AEG K + +VA S QL D Q QE+ TK+ LE
Sbjct: 1300 TGMLNEAEGK----AIKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDL----RENDRLEFHRLSEENTLLKNDLGRVRQELEA 1109
E++ ++ +L + + LE+H+ + + + + L+ R ++E+E
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 1110 AESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ-------- 1161
++ + + L+K K + E++ L N + +S L + + Q
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 1162 ------EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC-------- 1207
E +A+ E L ++LEE + + ++ + L+ E+E
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 1208 ------LNQEHQSLQLPWSELTQTLEESQDQVQG---AHLRLRQAQAQHLQEVRLVPQDR 1258
L + ++L+ E+ LEE +D++Q A LRL EV + Q
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL---------EVNM--QAL 1579
Query: 1259 VAELHRLLSLQGEQ-ARRRLDAQREEHEKQLKATEERVEEA---------EMILKNMEML 1308
+ R L + EQ +R QR+ HE + + +ER + A E LK++E+
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 1309 LQEKVDKLKEQFEKNTKSDLLLKELY--VENAHLVR-----ALQATEEKQRGAEKQSRLL 1361
+ +E ++ K +K+ +E+A R + E+K + E L
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1362 EEKVRALNK 1370
+E + A +
Sbjct: 1700 QEDLAAAER 1708
Score = 66.2 bits (160), Expect = 2e-10
Identities = 68/328 (20%), Positives = 149/328 (45%), Gaps = 29/328 (8%)
Query: 1049 IALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHR----LSEENTLLKNDLGRVR 1104
+ + R++++M+ K ED ++ ++ EN+ E + L+EE LL+ L
Sbjct: 852 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 1105 QELEAAESTH---DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+ AE A+++E+E + + E E E +Q Q + +++Q + + + +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSE 1221
E + + + +VT + + LE+ + Q++++ K E + L+ S+
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----------ERKLLEERISD 1017
Query: 1222 LTQTLEESQDQVQG-AHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQ 1280
LT L E +++ + L+ + EVRL +++ + + E+ +R+L+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-------ELEKLKRKLEGD 1070
Query: 1281 REEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHL 1340
+ +Q+ + ++ E +M L E LQ + +L ++ + + ++EL + L
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 1341 VRALQATEEKQRGAEKQSRLLEEKVRAL 1368
L + + AEKQ R L E++ AL
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEAL 1158
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/285 (21%), Positives = 123/285 (43%), Gaps = 16/285 (5%)
Query: 1102 RVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+V+ L+ + Q KE E L+K KE+ L Q + + N+ QL
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ----QQSDQIQKLRVELECLNQEHQSLQL 1217
E + A+ EE RV + Q LEE++ + ++ D+ Q+L+ E + + Q+ L+
Sbjct: 906 ETELY-AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 1218 PWSELTQTLEESQDQVQGAHLRLRQA---------QAQHLQEVRLVPQDRVAELHRLLSL 1268
E ++ Q + A ++++ Q L + R + ++R+++L L+
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 1269 QGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDL 1328
+ E+A+ L + +HE + E R+++ E + +E L ++ + E+
Sbjct: 1025 EEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 1329 LLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVS 1373
+ EL ++ A LQA + Q +K+R L +S
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 96.3 bits (238), Expect = 2e-19
Identities = 228/1108 (20%), Positives = 437/1108 (39%), Gaps = 189/1108 (17%)
Query: 392 QVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLR 451
Q E++ + D+ ++ ER +K E +KE++ HS QLTE+K +LL+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENE-LKELEQKHS---QLTEEK------------NLLQ 893
Query: 452 SEVEAERELFWE--QAHRQRAALEWDVGRLQAE-EAGLREKLTLALK---ENSRLQKEIV 505
+++AE EL+ E + + AA + ++ + E EA L E+ + E ++ ++++
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 506 EVVEKLSDSERLALKLQ----------KDLE---FVLKDKLEPQSAELLAQEERFAAV-- 550
++ E+L + E KLQ K LE V+ D+ S E EER + +
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 551 -LKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLG 609
L E E K ++L ++ ++ + L RL K S + +R+L G +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIA 1072
Query: 610 NSAPVSIETELMMEQVKEHYQDLRTQLET----------KVNYYEREIAALKRNFEKERK 659
+ E ++ + + +E Q +L+ K+ E I+ L+ + + ER
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 660 DMEQARRREVSV---LEGQKADLE----------ELHEKSQEVIWGLQEQLQDTARGPEP 706
+A +++ + LE K +LE EL K ++ + L++ L + R E
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 707 EQMGLAPCCTQALCGLALRHHSHLQQIRR-------------EAEAELSGELSGLGALPA 753
+ + QA+ L L+Q +R + A+L+GEL LG
Sbjct: 1193 QVQEMRQKHAQAVEELT----EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 754 -----RRDLTLELEEPPQGPLPRGSQRSE--------QLELE-----------RALKLQP 789
++ L +++E R+E Q E+E +A+KL
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 790 CASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPK---DGLVAGSGQEGTRGL 846
+ +Q+ + L +EE LE E +L + + A E
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 847 LPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERW 906
L ++ ++ L D + EA G +R Q + TQ A ++ E+
Sbjct: 1369 LNIQLSDSKKKLQ-----DFASTVEALEEGKKRFQKEIENLTQQYEEKAA--AYDKLEKT 1421
Query: 907 SRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAA 966
+D +V + + + LE+ + LL E++ S A
Sbjct: 1422 KNRLQQELDDLVVDLDNQR--QLVSNLEKKQRKFDQLLAEEKNISSKY-----------A 1468
Query: 967 SCRGQAERLQAIQEERARSWSRGTQE--QASEQQARAEGALEPGCHKHSVEVARRGSLPS 1024
R +AE +E +A S +R +E +A E+ R L + +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML-------------KAEMED 1515
Query: 1025 HLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRA------------- 1071
+ D G +L ++K ALE + ++M+T+L LED ++A
Sbjct: 1516 LVSSKDDVGKNVHELE-----KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 1072 ---------LEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIE 1122
L+ + E R + R E D + R AA+ + K++E
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 1123 VLK----KDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQ 1178
+ K +E+A ++ L Q ++++ +L ++ A ++ + + +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 1179 MLTQSLEEVVRSGQQQSDQIQKLRVEL-------ECLNQEHQSLQLPWSELTQTLEESQD 1231
L + L R+ +Q + ++L EL L E + L+ ++L + LEE Q
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 1232 QVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKAT 1291
++ R+R+A Q+ + + E R + + E AR++L+ Q +E +L
Sbjct: 1751 NMEAMSDRVRKA----TQQAEQLSNELATE--RSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 1292 EERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTK-SDLLLKELYVENAHLVRALQATEEK 1350
E V+ K+ L+ K+ +L+EQ E+ + K L ++ L L E++
Sbjct: 1805 EGAVKSK---FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Query: 1351 QRGAEKQSRLLEEKVRALNKLVSRIAPA 1378
++ AE+ E+ + +L ++ A
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Score = 78.2 bits (191), Expect = 5e-14
Identities = 173/872 (19%), Positives = 344/872 (39%), Gaps = 101/872 (11%)
Query: 352 EKVNLLELTWALDNELM-TVDS-AVQQAALACYHQELSYQQGQVEQLARERDKARQDLER 409
+K +L E AL EL T+DS A QQ A QE++ + +++ R + Q++ +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 410 AEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQR 469
+ +E + E + + +K + LE+ + LR +A++E+ ++
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-----EHKK 1254
Query: 470 AALEWDVGRLQAE-EAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV 528
LE V LQ++ G R + L K + +LQ E+ V L+++E A+KL KD+ +
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 529 LKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAEL-EGLWARLPKNRHSPS 587
+ Q ELL +E R K R L++ + LQ +L E + A+ RH +
Sbjct: 1314 SSQLQDTQ--ELLQEETRQKL---NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 588 WSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREI 647
+ L +S + +E ++E + + ++E YE +
Sbjct: 1369 LNIQ----------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 648 AALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPE 707
AA + EK + ++Q V L+ Q+ + L +K ++ L E+ +++ +
Sbjct: 1413 AAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 708 QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQG 767
A + L+L + + EA+ EL + L E+E+
Sbjct: 1472 DRAEAEAREKETKALSL---ARALEEALEAKEELE---------RTNKMLKAEMEDLVSS 1519
Query: 768 PLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQ 827
G E + +RAL+ Q +M L E+EL+ ++ LE MQ
Sbjct: 1520 KDDVGKNVHELEKSKRALETQ------MEEMKTQLEELEDELQATEDAKL---RLEVNMQ 1570
Query: 828 AL----PKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQ 883
AL +D E R L + E L + + A A +++
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------EDERKQRALAAAAKKKLEG 1624
Query: 884 DTEATQSPAPAPAPASHGPSERWSRMQPCGVD-----GDIVPKEPEPFGASAAGLEQPGA 938
D + + A + ++ ++Q D D E F + ++ +
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Query: 939 RELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERL---QAIQEERARSWSRGTQ--EQ 993
E L+ + D + + + L A L A+Q+E+ R +R Q E+
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 994 ASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALER 1053
E+Q E A+ K + + + + +LA + + Q+ +A ++ LER
Sbjct: 1745 LEEEQGNME-AMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQ------LER 1792
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAEST 1113
+ ++ +KL +E V++ + L+ + ++ +++E
Sbjct: 1793 QNKELRSKLHEMEGAVKS----------------KFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 1114 HDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEH 1173
A K ++ K ++ ++E + + YK+Q + N RV QL ++ + +++
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVEL 1205
+ L + L+E S + ++ L+ +L
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 72.4 bits (176), Expect = 3e-12
Identities = 90/424 (21%), Positives = 198/424 (46%), Gaps = 53/424 (12%)
Query: 962 LRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGS 1021
++P Q E +QA ++E ++ E+Q +AE L+ KHS
Sbjct: 841 VKPLLQVTRQEEEMQAKEDEL---------QKTKERQQKAENELKELEQKHS-------- 883
Query: 1022 LPSHLQLADPQGSWQEQLAA-----PEEGETKIALEREKDDMETKLLHLEDVVRALEKHV 1076
QL + + QEQL A E E ++ L +K ++E ++LH ++ LE+
Sbjct: 884 -----QLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE-EILH--EMEARLEEEE 935
Query: 1077 DLRENDRLEFHRLSEENTLLKNDLGR---VRQELEAAESTHDAQRKEI--EVLKKDKEKA 1131
D + + E +++++ L+ L RQ+L+ + T +A+ K++ E+L D +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN- 994
Query: 1132 CSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSG 1191
L+++ + ++++S L + + ++A +H I L L++ +S
Sbjct: 995 ----NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 1192 QQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQH---L 1248
Q+ +KL + +++ LQ +EL L + ++++Q A RL AQ L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 1249 QEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVE---EAEMILKNM 1305
+++R + + +++L L + AR + + Q+ + ++L+A + +E ++ + +
Sbjct: 1111 KKIREL-EGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 1306 EMLLQEKVDKLKEQFEKNTKS-DLLLKELYVENAHLVRALQATEEKQRGA----EKQSRL 1360
+++V LK+ ++ T+S + ++E+ ++A V L E+ + A +K +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 1361 LEEK 1364
LE++
Sbjct: 1229 LEKE 1232
Score = 71.2 bits (173), Expect = 6e-12
Identities = 195/969 (20%), Positives = 362/969 (37%), Gaps = 188/969 (19%)
Query: 476 VGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSD--SERLALKLQKDLEFVLKDKL 533
V R + E ++L + + + E+ E+ +K S E+ L+ Q E L +
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 534 EPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGR 593
E L A+++ +L E E + + +DR +LQAE + + ++ R
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 594 RR----------QLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLE-----T 638
++ ++ L + + +S E +L+ E++ + +L + E T
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 639 KV-NYYEREIAALK---RNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQ 694
K+ N +E I+ L+ + EK R+++E+ +R+ LEG +D E Q I L+
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRK----LEGDASDFHEQIADLQAQIAELK 1082
Query: 695 EQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPAR 754
QL A+ E Q LA L + ++ L++IR EL G +S L
Sbjct: 1083 MQL---AKKEEELQAALA-----RLDDEIAQKNNALKKIR-----ELEGHISDL------ 1123
Query: 755 RDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARG 814
E L+ ERA A K + L E E L+
Sbjct: 1124 ---------------------QEDLDSERA------ARNKAEKQKRDLGEELEALKTELE 1156
Query: 815 KRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAG 874
+D + + E++A + E + A + S EA
Sbjct: 1157 DTLDSTATQQELRAKREQ----------------------EVTVLKKALDEETRSHEAQV 1194
Query: 875 AGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLE 934
R++ AQ E +E+ + + + D + E A AG
Sbjct: 1195 QEMRQKHAQAVEEL--------------TEQLEQFKRAKANLDKNKQTLEKENADLAG-- 1238
Query: 935 QPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQA 994
EL +LG + + + + E ++ S ER +A ++ + E
Sbjct: 1239 -----ELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESV 1292
Query: 995 SEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKI-ALER 1053
+ AEG K + +VA S QL D Q QE+ TK+ LE
Sbjct: 1293 TGMLNEAEGK----AIKLAKDVASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 1054 EKDDMETKLLHLEDVVRALEKHVDL----RENDRLEFHRLSEENTLLKNDLGRVRQELEA 1109
E++ ++ +L + + LE+H+ + + + + L+ R ++E+E
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 1110 AESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ-------- 1161
++ + + L+K K + E++ L N + +S L + + Q
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 1162 ------EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC-------- 1207
E +A+ E L ++LEE + + ++ + L+ E+E
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 1208 ------LNQEHQSLQLPWSELTQTLEESQDQVQG---AHLRLRQAQAQHLQEVRLVPQDR 1258
L + ++L+ E+ LEE +D++Q A LRL EV + Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL---------EVNM--QAL 1572
Query: 1259 VAELHRLLSLQGEQ-ARRRLDAQREEHEKQLKATEERVEEA---------EMILKNMEML 1308
+ R L + EQ +R QR+ HE + + +ER + A E LK++E+
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 1309 LQEKVDKLKEQFEKNTKSDLLLKELY--VENAHLVR-----ALQATEEKQRGAEKQSRLL 1361
+ +E ++ K +K+ +E+A R + E+K + E L
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1362 EEKVRALNK 1370
+E + A +
Sbjct: 1693 QEDLAAAER 1701
Score = 66.2 bits (160), Expect = 2e-10
Identities = 68/328 (20%), Positives = 149/328 (45%), Gaps = 29/328 (8%)
Query: 1049 IALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHR----LSEENTLLKNDLGRVR 1104
+ + R++++M+ K ED ++ ++ EN+ E + L+EE LL+ L
Sbjct: 845 LQVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 1105 QELEAAESTH---DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+ AE A+++E+E + + E E E +Q Q + +++Q + + + +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSE 1221
E + + + +VT + + LE+ + Q++++ K E + L+ S+
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK----------ERKLLEERISD 1010
Query: 1222 LTQTLEESQDQVQG-AHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQ 1280
LT L E +++ + L+ + EVRL +++ + + E+ +R+L+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-------ELEKLKRKLEGD 1063
Query: 1281 REEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHL 1340
+ +Q+ + ++ E +M L E LQ + +L ++ + + ++EL + L
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 1341 VRALQATEEKQRGAEKQSRLLEEKVRAL 1368
L + + AEKQ R L E++ AL
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEAL 1151
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/285 (21%), Positives = 123/285 (43%), Gaps = 16/285 (5%)
Query: 1102 RVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQ 1161
+V+ L+ + Q KE E L+K KE+ L Q + + N+ QL
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDE-LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 1162 EASTHQAQNEEHRVTIQMLTQSLEEVVRSGQ----QQSDQIQKLRVELECLNQEHQSLQL 1217
E + A+ EE RV + Q LEE++ + ++ D+ Q+L+ E + + Q+ L+
Sbjct: 899 ETELY-AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 1218 PWSELTQTLEESQDQVQGAHLRLRQA---------QAQHLQEVRLVPQDRVAELHRLLSL 1268
E ++ Q + A ++++ Q L + R + ++R+++L L+
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 1269 QGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDL 1328
+ E+A+ L + +HE + E R+++ E + +E L ++ + E+
Sbjct: 1018 EEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 1329 LLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVS 1373
+ EL ++ A LQA + Q +K+R L +S
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 89.7 bits (221), Expect = 2e-17
Identities = 202/905 (22%), Positives = 359/905 (39%), Gaps = 169/905 (18%)
Query: 491 TLALKENSRLQKEIVEVVEKLSDSERLALKL---QKDLEFVLKDKLEPQSA--ELLAQEE 545
T A+ L +++ E+ KL + + KL Q LE L++K E S ELL + +
Sbjct: 355 TKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRK 414
Query: 546 RFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGI 605
A + + L D+ ++L+ LE L + + + G PA
Sbjct: 415 GEAQQSNKELQNMKRLLDQGEDLRHGLETQVMEL-----------QNKLKHVQGPEPAKE 463
Query: 606 SFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQAR 665
L + +ET ++E+V E Q + QL + ERE+ ALK ++E +Q
Sbjct: 464 VLLKDL----LETRELLEEVLEGKQRVEEQLRLR----ERELTALKGALKEEVASRDQ-- 513
Query: 666 RREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALR 725
++E + ++ Q L+ +QD A +
Sbjct: 514 ------------EVEHVRQQYQRDTEQLRRSMQD-----------------------ATQ 538
Query: 726 HHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERAL 785
H+ L+ R++ A + G L ELEE + S + E RA
Sbjct: 539 DHAVLEAERQKMSALVRG-------------LQRELEETSEETGHWQSMFQKNKEDLRAT 585
Query: 786 KLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRG 845
K Q + L +E+EE+E G++++ E E A + TR
Sbjct: 586 K----------QELLQLRMEKEEMEEELGEKIEVLQRELEQ---------ARASAGDTRQ 626
Query: 846 LLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSER 905
+ L+ R+S+E AG R + + A +
Sbjct: 627 VEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQL 686
Query: 906 WSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAR-ELPLLGTERDASQTQPRMW--EPPL 962
+Q D + K A A L Q A E L T+ + + + R+ E L
Sbjct: 687 QKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQL 746
Query: 963 RPA-----------ASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHK 1011
+ A R + +RL+A +++ + + +E+ S A A+ ALE +
Sbjct: 747 KETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS--LAAAKRALEARLEE 804
Query: 1012 HSVEVARRGSLPSHLQLA-DPQGSWQEQL--AAPEEGETKIALEREKDDMETKLLHL-ED 1067
+AR G L A + +G +E L E E K L+R D + +L + ED
Sbjct: 805 AQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGED 864
Query: 1068 VVRALEKHV----DLRENDRLEF--------------HRLSEENTLLKNDLGRVRQELEA 1109
+AL++ D +E R E + S + L++++ R+RQ L+A
Sbjct: 865 SKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQA 924
Query: 1110 AESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQ 1169
+++ D R + E+L + + E E R + QL L +V +L E
Sbjct: 925 SQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL------ 978
Query: 1170 NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQ-------KLRVELEC----LNQEHQSL--- 1215
+E + T+++LT V G+ Q DQ++ R +LEC L ++++ L
Sbjct: 979 -DEEKNTVELLTDR----VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTR 1033
Query: 1216 -------QLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSL 1268
Q P + L+Q ESQ+Q+ L+ + + LQ + +V EL S+
Sbjct: 1034 LASSEGFQKPSASLSQL--ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKEL----SI 1087
Query: 1269 QGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDL 1328
Q E R+ ++ Q+++ ++KA + +V+EAE ++ ++ L ++ +++EQ E N +
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQA 1147
Query: 1329 LLKEL 1333
+K L
Sbjct: 1148 RIKSL 1152
Score = 67.4 bits (163), Expect = 9e-11
Identities = 176/824 (21%), Positives = 316/824 (38%), Gaps = 167/824 (20%)
Query: 111 RRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFE 170
+R R + D+ E++ Q++ + W S++ S + A+S + F
Sbjct: 208 QRKRSKSLDSRLPRDTFEERERQST---NHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFS 264
Query: 171 AQGQLQTWDSEDFGSPQKSCSP----SFDTPESQIRGVWEELGVGSSGHL---------- 216
Q Q W + F P++S F + +R E GS H+
Sbjct: 265 RSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILRE 324
Query: 217 --SEQELAV--------------------VCQSVGLQGLEKEELEDLFNKLDQDGDGKVS 254
SE E +V ++V QG ++E+L KLD++ +
Sbjct: 325 GSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQK 384
Query: 255 LEEFQLGLF------SHEPALLLESSTRVKPSKAWSHYQVPE--------ESGCHTTTTS 300
LE Q+GL + E + L E R K S+ ++ E H T
Sbjct: 385 LEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQ 444
Query: 301 SLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLE-- 358
++ L + L+ + D + E + G++ V+E++ L E
Sbjct: 445 -VMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ-------RVEEQLRLRERE 496
Query: 359 ---LTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQD--------- 406
L AL E+ + D V+ H YQ+ EQL R A QD
Sbjct: 497 LTALKGALKEEVASRDQEVE-------HVRQQYQR-DTEQLRRSMQDATQDHAVLEAERQ 548
Query: 407 ----LERAEKRNLE------------FVKEMDDCHSTLEQLTEKKIK--HLEQGYRERLS 448
L R +R LE F K +D +T ++L + +++ +E+ E++
Sbjct: 549 KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIE 608
Query: 449 LLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGL---REKLTLALKENSR-LQKEI 504
+L+ E+E R + RQ L+ ++ R Q E L R+ +A + R L+K++
Sbjct: 609 VLQRELEQARASAGDT--RQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQL 666
Query: 505 VEV---VEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE----YELK 557
+ ++ + E L+LQK L+ + +D E A+++A+ E A VL + E
Sbjct: 667 AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAE--ATVLGQRRAAVETT 724
Query: 558 CRDLQDRNDELQAELEGLWARLPKNRHSPSWSP-------------DGRRRQLPGLGPAG 604
R+ Q+ NDE + + GL +L + R + ++QL A
Sbjct: 725 LRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNAS 784
Query: 605 ISFLGNSAPVSIETELMMEQVK-------EHYQDLRTQLETKVNY----------YEREI 647
G+ A E +E+ + + Q L LE + E +
Sbjct: 785 QEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQK 844
Query: 648 AALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPE 707
L R ++ K++E+ L+ +A LE+ EK++ + Q Q +D A E
Sbjct: 845 RLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKT 904
Query: 708 QMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQG 767
GL+ R +Q++R+ +A + + AR D L L + QG
Sbjct: 905 SGGLS------------RLQDEIQRLRQALQASQAERDT------ARLDKEL-LAQRLQG 945
Query: 768 PLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELEL 811
L + ++ ++ + +RA +L+ EK +++ L E+ +EL
Sbjct: 946 -LEQEAENKKRSQDDRARQLKG-LEEKVSRLETELDEEKNTVEL 987
Score = 67.4 bits (163), Expect = 9e-11
Identities = 193/894 (21%), Positives = 354/894 (39%), Gaps = 137/894 (15%)
Query: 392 QVEQLARERD---KARQDLERAE---KRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRE 445
+VE+L R+ D K RQ LE ++ +R LE ++ ++C S L++L E++ +Q +E
Sbjct: 367 KVEELQRKLDEEVKKRQKLEPSQVGLERQLE--EKTEEC-SRLQELLERRKGEAQQSNKE 423
Query: 446 RLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGL------REKLTLALKENSR 499
++ R +Q R LE V LQ + + +E L L E
Sbjct: 424 LQNMKR---------LLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474
Query: 500 LQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCR 559
L +E++E +++ + RL + L+ LK+++ + E+ +++ ++ +
Sbjct: 475 LLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQ 534
Query: 560 DLQDRNDELQAE-------LEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSA 612
D + L+AE + GL L + ++ L L
Sbjct: 535 DATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELL---- 590
Query: 613 PVSIETELMMEQVKEHYQDLRTQLET---------KVNYYEREIAALK---RNFEKERKD 660
+ +E E M E++ E + L+ +LE +V ++E+ + + + ER+
Sbjct: 591 QLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQS 650
Query: 661 MEQARRREVSVLEGQKADLE-------ELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAP 713
E A R LE Q A L EL E++ ++ LQ+ QD E+ A
Sbjct: 651 QEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC------EEASKAK 704
Query: 714 CCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGS 773
+A + + + ++ RE + E + E RR L LE + L G
Sbjct: 705 MVAEAEATVLGQRRAAVETTLRETQEE-NDEFR-------RRILGLEQQLKETRGLVDGG 756
Query: 774 QRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDG 833
E +E KLQ +EK+ A +EEE LA KR LE + L + G
Sbjct: 757 ---EAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLG 813
Query: 834 -----LVAGSGQEGTRGLLPLRPGCG--ERPLAWLAPGDGRESEEAAGAGPRRRQA-QDT 885
L +EG + + LR G E L R ++E G +QA Q
Sbjct: 814 QEQQTLNRALEEEGKQREV-LRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQL 872
Query: 886 EATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLE---QPGARELP 942
+A A ++R ++ E E + L+ Q + L
Sbjct: 873 QAQLEDYKEKARREVADAQRQAKDW---------ASEAEKTSGGLSRLQDEIQRLRQALQ 923
Query: 943 LLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAE 1002
ERD ++ + L+ +AE + Q++RAR +G +E+ S R E
Sbjct: 924 ASQAERDTARLDKELLAQRLQ---GLEQEAENKKRSQDDRARQ-LKGLEEKVS----RLE 975
Query: 1003 GALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGE-TKIALEREKDDMETK 1061
L+ K++VE+ Q+ + ++ +A ++ E KI+LER+ D++T+
Sbjct: 976 TELDE--EKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTR 1033
Query: 1062 LLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEI 1121
L E + +L +N LL+ L +E +ST+ +++
Sbjct: 1034 LASSEGF-----------QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKV 1082
Query: 1122 EVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLT 1181
+ L E + Q+ DQ QL++RV L + Q +E I+ L
Sbjct: 1083 KELSIQIED----------ERQHVNDQKDQLSLRVKAL-------KRQVDEAEEEIERLD 1125
Query: 1182 QSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQG 1235
++ R ++Q + ++L+ ++ L ++ W + +++ ES + +G
Sbjct: 1126 GLRKKAQREVEEQHEVNEQLQARIKSLEKD------SWRKASRSAAESALKNEG 1173
Score = 65.5 bits (158), Expect = 3e-10
Identities = 71/345 (20%), Positives = 146/345 (42%), Gaps = 24/345 (6%)
Query: 1051 LEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEE----------NTLLKNDL 1100
LER K + + L+++ R L++ DLR + L + +L DL
Sbjct: 410 LERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469
Query: 1101 GRVRQELEAA-------ESTHDAQRKEIEVLKKD-KEKACSEMEVLNRQNQNYKDQLSQL 1152
R+ LE E + +E+ LK KE+ S + + Q Y+ QL
Sbjct: 470 LETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQL 529
Query: 1153 NVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEH 1212
+ Q+ + +A+ ++ ++ L + LEE QK + +L QE
Sbjct: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQEL 589
Query: 1213 QSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQ 1272
L++ E+ + L E + +Q L +A A ++V ++ ++ + L LQ E+
Sbjct: 590 LQLRMEKEEMEEELGEKIEVLQ-RELEQARASAGDTRQVEVLKKELLRTQEELKELQAER 648
Query: 1273 ARRRLDAQREEHEKQLKATEERVE-EAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLK 1331
+ + + + E + + RVE + L+ + LQ+ + +L++ E+ +K+ ++ +
Sbjct: 649 QSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAE 708
Query: 1332 E----LYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLV 1372
L A + L+ T+E+ ++ LE++++ LV
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLV 753
Score = 62.8 bits (151), Expect = 2e-09
Identities = 97/454 (21%), Positives = 192/454 (42%), Gaps = 46/454 (10%)
Query: 948 RDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEP 1007
+DA+Q + + +A RG L+ EE W Q+ + +A + L+
Sbjct: 534 QDATQDHAVLEAERQKMSALVRGLQRELEETSEETGH-WQSMFQKNKEDLRATKQELLQL 592
Query: 1008 GCHKHS--------VEVARRGSLPSHLQLADPQGS--WQEQLAAPEEGETKIALEREKDD 1057
K +EV +R + D + +++L +E ++ ER+ +
Sbjct: 593 RMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQE 652
Query: 1058 METKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQ 1117
+ + H + R LEK + + + L E+N L+ L ++RQ+ E A
Sbjct: 653 VAGR--HRD---RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVA 707
Query: 1118 RKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQL-----NVRVLQLGQEASTHQAQNEE 1172
E VL + + + + +N ++ ++ L R L G EA + +++
Sbjct: 708 EAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKL 767
Query: 1173 HRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQ 1232
R+ + Q LEE + + Q++ + + LE +E Q + QTL + ++
Sbjct: 768 QRLEAE--KQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEE 825
Query: 1233 VQGAHLRLRQAQAQHLQEVRLVPQ--DRVAELHRLLSLQGEQARRRLDAQREEHEKQL-- 1288
LR+ +A+ ++ RL+ + DR+ + + +QA ++L AQ E+++++
Sbjct: 826 EGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR 885
Query: 1289 ------KATEERVEEAEMILKNMEMLLQEKVDKLKE-----QFEKNTKSDLLLKELYVEN 1337
+ ++ EAE + LQ+++ +L++ Q E++T L KEL +
Sbjct: 886 EVADAQRQAKDWASEAEKTSGGLSR-LQDEIQRLRQALQASQAERDTAR--LDKELLAQ- 941
Query: 1338 AHLVRALQATEEKQRGAEKQSRL---LEEKVRAL 1368
L Q E K+R + ++R LEEKV L
Sbjct: 942 -RLQGLEQEAENKKRSQDDRARQLKGLEEKVSRL 974
Score = 55.5 bits (132), Expect = 4e-07
Identities = 73/338 (21%), Positives = 148/338 (43%), Gaps = 46/338 (13%)
Query: 1051 LEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGR----VRQE 1106
L+RE ++ + H + + + ++ + + + L+ EE ++ +LG +++E
Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEE---MEEELGEKIEVLQRE 613
Query: 1107 LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQN------YKDQLSQLNVRVLQLG 1160
LE A ++ R ++EVLKK+ + E++ L + Q+ ++D+ + + VL++
Sbjct: 614 LEQARASAGDTR-QVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
Query: 1161 QEASTH-QAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELEC--LNQEHQSLQL 1217
+ + QN + + T+Q L Q EE ++ K+ E E L Q +++
Sbjct: 673 ADRGRELEEQNLQLQKTLQQLRQDCEEASKA---------KMVAEAEATVLGQRRAAVET 723
Query: 1218 PWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRL 1277
E + +E + ++ G +L++ + LV E LQ RL
Sbjct: 724 TLRETQEENDEFRRRILGLEQQLKETRG-------LVDGGEAVEARLRDKLQ------RL 770
Query: 1278 DAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVEN 1337
+A++++ E+ L A++E + +E L+E L ++ + L+E +
Sbjct: 771 EAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR 830
Query: 1338 AHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRI 1375
L R EE Q RLL+ V LNK + +I
Sbjct: 831 EVLRRGKAELEE-------QKRLLDRTVDRLNKELEKI 861
Score = 49.3 bits (116), Expect = 3e-05
Identities = 89/405 (21%), Positives = 171/405 (42%), Gaps = 47/405 (11%)
Query: 340 REILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARE 399
+++ ++L+ S +E+ +L AL+ L Q LA QE +E+ ++
Sbjct: 775 QQLEEALNASQEEEGSLAAAKRALEARLEEA-----QRGLARLGQEQQTLNRALEEEGKQ 829
Query: 400 RDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERE 459
R+ R+ E++ + +D + LE++ E + L+Q ++A+ E
Sbjct: 830 REVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQ------------LQAQLE 877
Query: 460 LFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKL--SDSERL 517
+ E+A R+ A D R + A EK + L SRLQ EI + + L S +ER
Sbjct: 878 DYKEKARREVA----DAQRQAKDWASEAEKTSGGL---SRLQDEIQRLRQALQASQAERD 930
Query: 518 ALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWA 577
+L K+L LE ++ ++ A LK E K L+ DE + +E L
Sbjct: 931 TARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTD 990
Query: 578 RLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLE 637
R+ + R D R +L SA +E + + ++ +DL+T+L
Sbjct: 991 RVNRGRD----QVDQLRTEL---------MQERSARQDLECDKI--SLERQNKDLKTRLA 1035
Query: 638 TKVNYYEREIAALKRNFEKE-RKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQ 696
+ + + + + + + ++ QA RE +VL+ LE K +E+ ++++
Sbjct: 1036 SSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLE---RKVKELSIQIEDE 1092
Query: 697 LQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAEL 741
Q + +Q+ L + A L +R++A+ E+
Sbjct: 1093 RQHV--NDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
Score = 42.4 bits (98), Expect = 0.003
Identities = 66/312 (21%), Positives = 131/312 (41%), Gaps = 34/312 (10%)
Query: 162 KEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSS----GHLS 217
++A+ E+ +AQ Q + W SE + S + +I+ + + L + L
Sbjct: 881 EKARREVADAQRQAKDWASE-----AEKTSGGLSRLQDEIQRLRQALQASQAERDTARLD 935
Query: 218 EQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRV 277
++ LA Q + + K+ +D + + + KVS E +L + LL + R
Sbjct: 936 KELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRG 995
Query: 278 KPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLR-LFSSIDDGSGFAFPDQVLAMWT---- 332
+ ++ +E +SL + L + + GF P L+
Sbjct: 996 RDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQ 1055
Query: 333 --QEGIQ---NGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELS 387
QE +Q + +LQS + ++ KV EL+ +++E V+ Q +L
Sbjct: 1056 LLQERLQAEEREKTVLQSTNRKLERKVK--ELSIQIEDERQHVNDQKDQLSL-------- 1105
Query: 388 YQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERL 447
+V+ L R+ D+A +++ER + + +E+++ H EQL + +IK LE+ +
Sbjct: 1106 ----RVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQL-QARIKSLEKDSWRKA 1160
Query: 448 SLLRSEVEAERE 459
S +E + E
Sbjct: 1161 SRSAAESALKNE 1172
Score = 38.1 bits (87), Expect = 0.059
Identities = 48/203 (23%), Positives = 98/203 (48%), Gaps = 22/203 (10%)
Query: 1176 TIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWS----------ELTQT 1225
++ + ++ ++R G +S+ + +V L + ++ Q L + S ELT+
Sbjct: 310 SVDHMKATIYGILREGSSESETSVRRKVSL--VLEKMQPLVMVSSGSTKAVAGQGELTRK 367
Query: 1226 LEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHE 1285
+EE Q ++ + ++ + + R + +++ E RL L RR+ +AQ+
Sbjct: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQL-EEKTEECSRLQELL---ERRKGEAQQSN-- 421
Query: 1286 KQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQ 1345
K+L+ + +++ E + +E + E +KLK ++LLK+L +E L+ +
Sbjct: 422 KELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL-LETRELLE--E 478
Query: 1346 ATEEKQRGAEKQSRLLEEKVRAL 1368
E KQR E+Q RL E ++ AL
Sbjct: 479 VLEGKQR-VEEQLRLRERELTAL 500
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 86.7 bits (213), Expect = 1e-16
Identities = 259/1152 (22%), Positives = 454/1152 (39%), Gaps = 213/1152 (18%)
Query: 351 DEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERA 410
+E V + E A +N L +++ Q+ L +L Q +L E ++ R L A
Sbjct: 852 EELVKVREKQLAAENRLTEMETL--QSQLMAEKLQLQEQLQAETELCAEAEELRARLT-A 908
Query: 411 EKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRA 470
+K+ LE + CH LE E++ + + E+ + ++ E E +L E++ RQ+
Sbjct: 909 KKQELEEI-----CHD-LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 471 ALEW-----DVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDL 525
LE + +L+ E+ L ++ KE L+ I E L++ E + L K
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-- 1020
Query: 526 EFVLKDKLEPQSAEL---LAQEERFAAVLKEYELKCR----DLQDRNDELQA-------- 570
LK+K E +L L +EE+ L++ K DL D+ ELQA
Sbjct: 1021 ---LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077
Query: 571 ------ELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQ 624
EL+ AR+ + + + + R+L L + + E
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 625 VKEHYQDLRTQLETKVNYY----------EREIAALKRNFEKERKDMEQARRREVSVLEG 674
+ E + L+T+LE ++ E+E+ LK+ E+E K E A+ +E+
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE-AQIQEMRQKHS 1195
Query: 675 QKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIR 734
Q +EEL E+ ++ ++ L+ + E E+ LA L G H R
Sbjct: 1196 QA--VEELAEQLEQTK-RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK-----R 1247
Query: 735 REAEAELS--------GELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLE-----L 781
++ EA+L GE L +EL+ G L + +S +L L
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT-GLLSQSDSKSSKLTKDFSAL 1306
Query: 782 ERALK--LQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQA---LPKDGLVA 836
E L+ + E R ++ +S L++ E E K LE E +A L K
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVEDE----KNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 837 GSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPA 896
+ + + GC E +EE +R+ +D E
Sbjct: 1363 HAQVADMKKKMEDSVGCLET------------AEEV-----KRKLQKDLEGLSQRHEEKV 1405
Query: 897 PASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPR 956
A + +R+Q +D +V + + SA LE+ + LL E+ S
Sbjct: 1406 AAYDKLEKTKTRLQQ-ELDDLLVDLDHQR--QSACNLEKKQKKFDQLLAEEKTISAKY-- 1460
Query: 957 MWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEV 1016
A R +AE +E +A S +R +E A EQ+A E +
Sbjct: 1461 ---------AEERDRAEAEAREKETKALSLARALEE-AMEQKAELE----------RLNK 1500
Query: 1017 ARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEK-- 1074
R + + D G +L ++K ALE++ ++M+T+L LED ++A E
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELE-----KSKRALEQQVEEMKTQLEELEDELQATEDAK 1555
Query: 1075 ---HVDLRENDRLEFHR----LSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKD 1127
V+L+ + +F R E++ K L R +E+EA QR +K
Sbjct: 1556 LRLEVNLQAM-KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK 1614
Query: 1128 KEKACSEMEV-LNRQNQNYKDQLSQLNVRVLQLG-------------QEASTHQAQNEEH 1173
E ++E ++ N+N + + QL Q+ +E +NE+
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674
Query: 1174 RVTIQMLTQSLEEVVRSGQQQSDQIQKLRVEL--ECLN---------QEHQSLQLPWSEL 1222
+++ L+E + + ++ Q Q+ R EL E N +E + L+ ++L
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQL 1734
Query: 1223 TQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQRE 1282
+ LEE Q + + RL++A Q + + D L R + + E AR++L+ Q +
Sbjct: 1735 EEELEEEQGNTELINDRLKKANLQ----IDQINTD--LNLERSHAQKNENARQQLERQNK 1788
Query: 1283 EHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKS---------------- 1326
E + +L+ E V+ K L+ K+ +L+EQ + TK
Sbjct: 1789 ELKVKLQEMEGTVKSK---YKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Query: 1327 DLLLK--------ELYVENA--------HLVRALQATEEKQRGAEKQSRLLEEKVR---- 1366
D+LL+ E Y + A L R L+ EE+ + A R L+ ++
Sbjct: 1846 DVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Query: 1367 ---ALNKLVSRI 1375
A+N+ VS +
Sbjct: 1906 TADAMNREVSSL 1917
Score = 63.9 bits (154), Expect = 1e-09
Identities = 67/309 (21%), Positives = 143/309 (46%), Gaps = 26/309 (8%)
Query: 1084 LEFHRLSEENTLLKNDLGRVRQ----------ELEAAESTHDAQRKEIEVLKKDKEKACS 1133
L+ R EE + +L +VR+ E+E +S A++ +++ + + + C+
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 1134 EMEVLNRQNQNYKDQLSQ----LNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVR 1189
E E L + K +L + L RV + + QA+ ++ + IQ L + LEE
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE--E 955
Query: 1190 SGQQQSDQIQKLRVE--LECLNQEHQSLQLPWSELTQTLEESQDQVQG--AHLRLRQAQA 1245
+Q Q++K+ E L+ L +E L+ +L + + +D++ +L + ++
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS 1015
Query: 1246 QHLQEVRLVPQDRVAELHRLLSLQGEQ------ARRRLDAQREEHEKQLKATEERVEEAE 1299
+ L +++ + + +L L + +Q RR+L+ + Q+ + ++ E +
Sbjct: 1016 KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK 1075
Query: 1300 MILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSR 1359
M L E LQ + +++E+ + + ++EL + + L L++ + AEKQ R
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Query: 1360 LLEEKVRAL 1368
L E++ AL
Sbjct: 1136 DLGEELEAL 1144
Score = 62.4 bits (150), Expect = 3e-09
Identities = 118/534 (22%), Positives = 220/534 (41%), Gaps = 71/534 (13%)
Query: 333 QEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQ 392
Q+ Q E+ + L+ + K NL + L+NE + + V+ L + +++ +
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK--VLLQGKGDSEHKRKK 1249
Query: 393 VEQLARERDKARQDLERAEKRNLEFVK----EMDDCHSTLEQLTEKKIKHLEQGYRERLS 448
VE +E + ER + V E+D+ L Q K K + S
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD-----FS 1304
Query: 449 LLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEI---- 504
L S+++ +EL E+ +RQ+ +L + +++ E+ RE+L + L+K+I
Sbjct: 1305 ALESQLQDTQELLQEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 505 ---VEVVEKLSDS-------ERLALKLQKDLEFVLK---------DKLEPQSAELLAQEE 545
++ +K+ DS E + KLQKDLE + + DKLE L + +
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD 1423
Query: 546 RFAAVLKEYELKCRDL---QDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGP 602
L +L Q + D+L AE + + A+ + R + R ++ L
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA--EAEAREKETKALS- 1480
Query: 603 AGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDME 662
L + ++E + +E++ + + RT++E ++ + K + K ++E
Sbjct: 1481 -----LARALEEAMEQKAELERLNKQF---RTEME--------DLMSSKDDVGKSVHELE 1524
Query: 663 QARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGL 722
+++R +E K LEEL ++ Q +D E + + L G
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQAT--------EDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 723 ALRHHSHLQQI---RREAEAELSGELSGLG-ALPARRDLTLELEEPPQGPLPRGSQRSEQ 778
+ +Q+ RE EAEL E A+ AR+ L ++L++ R E
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 779 LELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKD 832
++ R KLQ + ++ + A EE L A+ S+EAEM L ++
Sbjct: 1637 IKQLR--KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688
Score = 51.2 bits (121), Expect = 7e-06
Identities = 139/638 (21%), Positives = 250/638 (39%), Gaps = 116/638 (18%)
Query: 129 EQQTQASLKSHLWRSASLESVESPKSD--EEAESTKEAQNELFEAQGQLQTWDSE--DFG 184
++ Q + L S L+ VE K+ E+ E +EA++ L + Q+ T ++ D
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL---EKQIATLHAQVADMK 1370
Query: 185 SPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDLFNK 244
+ +T E R + ++L S H E+++A + + ++EL+DL
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRH--EEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 245 LDQDGDGKVSLEEFQLG---LFSHEPALLL---------ESSTRVKPSKAWSHYQVPEES 292
LD +LE+ Q L + E + E+ R K +KA S + EE+
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEA 1488
Query: 293 GCHTTTTSSLVSLCSSLR-----LFSSIDD---------GSGFAFPDQVLAMWTQ-EGIQ 337
+ L L R L SS DD S A QV M TQ E ++
Sbjct: 1489 ---MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 338 NGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQ--------------------- 376
+ E+ + D + +VNL + + +L D ++
Sbjct: 1546 D--ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERK 1603
Query: 377 ------AALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQ 430
AA +L + ++ + RD+A + L + + + + ++E+DD ++ E+
Sbjct: 1604 QRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663
Query: 431 L------TEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEA 484
+ EKK+K +E E + L AER QA ++R L E A
Sbjct: 1664 ILAQAKENEKKLKSME---AEMIQLQEELAAAERAK--RQAQQER-------DELADEIA 1711
Query: 485 GLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQE 544
K LAL+E RL+ I ++ E+L + + + L+ K L+
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK---KANLQIDQINTDLNL 1768
Query: 545 ERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAG 604
ER A ++ E + L+ +N EL+ +L+ + + + + + + QL
Sbjct: 1769 ERSHA--QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE------ 1820
Query: 605 ISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQA 664
L N E + +QV+ + E K+ ++ +RN E+ + ++A
Sbjct: 1821 -EQLDNETK---ERQAACKQVR--------RTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Query: 665 RRREVSVLEGQKADLEELHEKSQEVIWG---LQEQLQD 699
R L+ K LEE E++Q LQ +L+D
Sbjct: 1869 STR----LKQLKRQLEEAEEEAQRANASRRKLQRELED 1902
Score = 43.9 bits (102), Expect = 0.001
Identities = 54/251 (21%), Positives = 102/251 (40%), Gaps = 39/251 (15%)
Query: 1013 SVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL 1072
+ E A+R + +LAD A G+ +ALE EK +E ++ LE+ +
Sbjct: 1691 AAERAKRQAQQERDELADE--------IANSSGKGALALE-EKRRLEARIAQLEEELEEE 1741
Query: 1073 EKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKAC 1132
+ + +L NDRL+ L + + DL R + E+ R+++E K+ +
Sbjct: 1742 QGNTELI-NDRLKKANLQIDQ--INTDLNLERSHAQKNENA----RQQLERQNKELKVKL 1794
Query: 1133 SEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVV---- 1188
EME YK ++ L ++ QL ++ + + ++ + L++V+
Sbjct: 1795 QEME--GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 1189 ---RSGQQQSDQIQKLRVELECL--------------NQEHQSLQLPWSELTQTLEESQD 1231
R+ +Q DQ K L+ L N + LQ + T+T +
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNR 1912
Query: 1232 QVQGAHLRLRQ 1242
+V +LR+
Sbjct: 1913 EVSSLKNKLRR 1923
Score = 42.4 bits (98), Expect = 0.003
Identities = 56/258 (21%), Positives = 113/258 (43%), Gaps = 30/258 (11%)
Query: 971 QAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLAD 1030
+AE +Q +QEE A + Q Q + E A G ++E RR +
Sbjct: 1679 EAEMIQ-LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR---------LE 1728
Query: 1031 PQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLS 1090
+ + E+ E+G T++ +R K ++ + + H EN R + R +
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKK-ANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 1091 EENTLLKNDL-GRVRQELEAAESTHDAQRKEIEVL----KKDKEKACSEMEVLNRQNQNY 1145
+E + ++ G V+ + +A+ + +A+ ++E K+++ AC ++ R +
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR---RTEKKL 1844
Query: 1146 KDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVEL 1205
KD L Q++ + A ++ Q ++ ++ L + LEE Q+ + +KL+ EL
Sbjct: 1845 KDVLLQVDDE----RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 1206 E-------CLNQEHQSLQ 1216
E +N+E SL+
Sbjct: 1901 EDATETADAMNREVSSLK 1918
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 85.5 bits (210), Expect = 3e-16
Identities = 249/1044 (23%), Positives = 395/1044 (37%), Gaps = 183/1044 (17%)
Query: 377 AALACYHQELSYQ--QGQVEQLARERDKARQDLERAEKRNLEFVKEMDD---CHSTLEQL 431
A++ C H+EL + QG ++ E A Q++ + + + D + LE L
Sbjct: 146 ASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEML 205
Query: 432 TEKKIKHLEQGYRER-LSLLR-SEVEAERE-LFWEQAHRQRAALEWDVGRLQAEEAGLRE 488
+ + L + RER L R +E+ ERE L RA E L + A +
Sbjct: 206 SRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKA 265
Query: 489 KLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFA 548
+L RL++E+ E E L DS+ L+ ++ + Q A+ L+ + + A
Sbjct: 266 QLR-------RLRQELEEKAELLLDSQAEVQGLEAEIRRLR------QEAQALSGQAKRA 312
Query: 549 AVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFL 608
+ +E R+ R LQ EL RL S + R L G+ A + L
Sbjct: 313 ELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEE--ERVLSGVLEASKALL 370
Query: 609 GNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRRE 668
E +E +E L ET +RE L+ + +++ R +
Sbjct: 371 ----------EEQLEAARERCARLH---ET-----QRENLLLRTRLGEAHAELDSLRHQ- 411
Query: 669 VSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHS 728
+++L E++ E+ LQ L+ P P G AP L G A
Sbjct: 412 ----------VDQLAEENVELELELQRSLE-----PPPGSPGEAP-----LAGAA----P 447
Query: 729 HLQQIRREAEA-----------ELSGELSGLGALPARRDLTLE----------LEEPPQG 767
LQ REAEA EL G L L P + LE LEE PQ
Sbjct: 448 SLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQT 507
Query: 768 PL-----PRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSL 822
P+ P+G + + +AL L P A + ++ E E + D
Sbjct: 508 PVAFDHSPQGLVQKARDGGPQALDLAPPALD---------SVLEASAECPQAPDSDPQEA 558
Query: 823 EAEMQALPKDGLVAG-SGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQ 881
E+ +QA D + S QE +P + +ES E AG RR
Sbjct: 559 ESPLQAAAMDPQASDWSPQESG------------------SPVETQESPEKAG----RRS 596
Query: 882 AQDTEATQSPAPAPAPASHGPS----ERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPG 937
+ + A+ +P P P E R P G++VP+ A GL Q G
Sbjct: 597 SLQSPASVAPPQGPGTKIQAPQLLGGETEGREAP---QGELVPE--------AWGLRQEG 645
Query: 938 ARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQ 997
P + S Q E P + GQAE + ++R R Q +Q
Sbjct: 646 PEHKP---GPSEPSSVQLEEQEGPNQGLDLATGQAEARE--HDQRLEGTVRDPAWQKPQQ 700
Query: 998 QARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDD 1057
++EGALE V+V G +P LA G +++ E + + E D+
Sbjct: 701 --KSEGALE-------VQVWE-GPIPGE-SLAS--GVAEQEALREEVAQLRRKAEALGDE 747
Query: 1058 METKLLHLE---DVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTH 1114
+E + LE L K + E HR +E + R+R+ +EAA
Sbjct: 748 LEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAW---EQARLREAVEAAGQEL 804
Query: 1115 DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHR 1174
++ +E E L + A E R+ + Q R+ L E H + E R
Sbjct: 805 ESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERER 864
Query: 1175 VTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQ 1234
+ L LE+ V G++ +++ L+ ELE E Q E + E + Q
Sbjct: 865 REKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQ-------EFLREKESQHQRYQ 917
Query: 1235 GAHLRLR---QAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKAT 1291
G RL QA A +E + + R +L L Q Q L ++ E QL T
Sbjct: 918 GLEQRLEAELQAAATSKEEALMELKTRALQLEEEL-FQLRQGPAGL-GPKKRAEPQLVET 975
Query: 1292 EE----RVEEAEMILKNMEMLLQEKVDKLKEQ---FEKNTKSDLLLKELYVENAHLVRAL 1344
+ VE + +L + LQ ++ L+ Q + + LL + E++ ++A
Sbjct: 976 QNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAE 1035
Query: 1345 QATEEKQ-RGAEKQSRLLEEKVRA 1367
++ E Q + ++ +LEE+VRA
Sbjct: 1036 KSVLEIQGQELHRKLEVLEEEVRA 1059
Score = 71.6 bits (174), Expect = 5e-12
Identities = 276/1155 (23%), Positives = 445/1155 (38%), Gaps = 245/1155 (21%)
Query: 391 GQVEQLARERDKARQDLERA--EKRNLEFVKEMDD-------CHSTLEQLTEKK--IKHL 439
G + +LARERD Q L E+ L E H QL K ++ L
Sbjct: 211 GTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRL 270
Query: 440 EQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENS- 498
Q E+ LL ++++ E+ +A +R E QA+ A L + AL+E +
Sbjct: 271 RQELEEKAELL---LDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAG 327
Query: 499 ---RLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSA----ELLAQEERFAAVL 551
RLQ+E+ E+L +E A K Q + E VL LE A +L A ER A L
Sbjct: 328 RLPRLQEELRRCRERLQAAE--AYKSQLEEERVLSGVLEASKALLEEQLEAARERCAR-L 384
Query: 552 KEYELKCRDLQDRNDELQAELEGLWARLPK-NRHSPSWSPDGRRRQLPGLGPAGISFLGN 610
E + + L+ R E AEL+ L ++ + + + +R P G G + L
Sbjct: 385 HETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAG 444
Query: 611 SAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVS 670
+AP S++ E+ E E L R E+E +++ R +
Sbjct: 445 AAP-SLQDEVR----------------------EAEAGRL-RTLERENREL----RGLLQ 476
Query: 671 VLEGQKADLEELHEKSQE--VIWGLQEQLQ-------------DTARGPEPEQMGLAPCC 715
VL+GQ L E +E V+ L+E Q AR P+ + LAP
Sbjct: 477 VLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPA 536
Query: 716 TQALCGLALRHHSHLQQIRREAEAELSGELSGLGAL---PARRDLTLELEEPPQGPLPRG 772
++ + +EAE+ L A P +E +E P+ R
Sbjct: 537 LDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRS 596
Query: 773 SQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGK--------RVDGP---- 820
S +S A P + Q L E E E +G+ R +GP
Sbjct: 597 SLQSP------ASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKP 650
Query: 821 ------SLEAEMQALPKDGLVAGSGQ----------EGT-------------RGLLPLRP 851
S++ E Q P GL +GQ EGT G L ++
Sbjct: 651 GPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQV 710
Query: 852 GCGERPLAWLAPGDG------------RESEEAAG----AGPRRRQAQDTEATQ-SPAPA 894
G P LA G R EA G A R+ +AQ+TEA + S A
Sbjct: 711 WEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELA 770
Query: 895 PAPASHGPSER------WSR------MQPCGVDGDIVPKEPEPF--GASAAGLEQ-PGAR 939
A + + R W + ++ G + + +E E +AAG E+ R
Sbjct: 771 QARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWER 830
Query: 940 ELPLLGTERDASQTQPRMWEPP----LRPAASCRGQAERLQAIQEE----------RARS 985
E L + +A++ + ++ E L A R + E LQA E+ R
Sbjct: 831 EGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEH 890
Query: 986 WSRGTQEQASEQQA-----------------RAEGALEPGCHKHSVEVARRGSLPSHLQL 1028
R ++ A E+Q R E L+ S E A LQL
Sbjct: 891 LQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAAT--SKEEALMELKTRALQL 948
Query: 1029 AD--------PQGSWQEQLAAPEEGETK----IALER-------EKDDMETKLLHLEDVV 1069
+ P G ++ A P+ ET+ I +ER EK ++ +L HLE +
Sbjct: 949 EEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQL 1008
Query: 1070 RALEKHVD--LRENDRLEFH--RLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLK 1125
+L+ L ++ R + H RL E ++L+ + ++LE E A R+ E +
Sbjct: 1009 GSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETR 1068
Query: 1126 KDKEKACSEMEVLNRQNQNYKDQLSQL---------NVRVLQLG-QEASTHQAQNEEHRV 1175
++ + + L + + + +L L N+R L+L +E Q + R
Sbjct: 1069 GQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRA 1128
Query: 1176 TIQMLTQSL----EEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQD 1231
+++ +L E +++ G +Q + L EL L EH Q+ +EL++ E +
Sbjct: 1129 SVEAQEVALLAERERLMQDGHRQ----RGLEEELRRLQSEHDRAQMLLAELSR--ERGEL 1182
Query: 1232 QVQGAHLRLRQAQAQHLQEVRLVPQ-DRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
Q + LR R A+ + L+ +L Q ++ E ++ L L + RL Q E QL++
Sbjct: 1183 QGERGELRGRLARLE-LERAQLEMQSQQLRESNQQLDL----SACRLTTQC-ELLTQLRS 1236
Query: 1291 TEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEK 1350
+E EE +L ++ L +E + L+ E +E Y++ + +R EK
Sbjct: 1237 AQE--EENRQLLAEVQALSRENRELLERSLESRDHLHREQRE-YLDQLNALR-----REK 1288
Query: 1351 QRGAEK---QSRLLE 1362
Q+ EK Q R+LE
Sbjct: 1289 QKLVEKIMDQYRVLE 1303
Score = 60.5 bits (145), Expect = 1e-08
Identities = 200/952 (21%), Positives = 352/952 (36%), Gaps = 153/952 (16%)
Query: 88 SSLESAASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLE 147
SSL+S AS A P G+K P+L TE R P Q L W
Sbjct: 596 SSLQSPASVA--PPQGPGTKIQA----PQLLGGETEGREAP----QGELVPEAWGLRQEG 645
Query: 148 SVESPKSDEEAESTKEAQN------ELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQI 201
P E + E Q +L Q + + D G+ + P++ P+ +
Sbjct: 646 PEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVR---DPAWQKPQQKS 702
Query: 202 RG-----VWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLE 256
G VWE G + + LA V Q +EE+ L K + GD ++ +
Sbjct: 703 EGALEVQVWE-------GPIPGESLA---SGVAEQEALREEVAQLRRKAEALGD-ELEAQ 751
Query: 257 EFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSID 316
+L + E A L + + + ++A +H + ++ ++ + L S
Sbjct: 752 ARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQER 811
Query: 317 DG--SGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAV 374
+ A + W +EG + L++ + +E++ +LE
Sbjct: 812 EALVEALAAAGRERRQWEREGSR-----LRAQSEAAEERMQVLE---------------- 850
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQ---- 430
E + E+ RE++ + +LE+A R E ++ LEQ
Sbjct: 851 ---------SEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALE 901
Query: 431 ----LTEKKIKHLE-QGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAG 485
L EK+ +H QG +RL +E + + LE ++ +L+ AG
Sbjct: 902 RQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAG 961
Query: 486 L--REKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQ-KDLEFVLKDKLEPQSAELLA 542
L +++ L E ++ VE + +E+ AL+ Q + LE L L+ ++ ELL
Sbjct: 962 LGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQL-GSLQGRAQELLL 1020
Query: 543 QEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGP 602
Q +R + + L+ + EL +LE L + R S + + G
Sbjct: 1021 QSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQS--------QEETRGQQQ 1072
Query: 603 AGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDME 662
A + A + E +E + ++DL+ + + RE+ + +R +E
Sbjct: 1073 ALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRA-LELAHRELQGRHEQLQAQRASVE 1131
Query: 663 QARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQ----- 717
+EV++L ++ +++ H + GL+E+L+ + QM LA +
Sbjct: 1132 ---AQEVALLAERERLMQDGHRQR-----GLEEELRRLQSEHDRAQMLLAELSRERGELQ 1183
Query: 718 --------ALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLEL----EEPP 765
L L L Q ++ E+ +LS L + +L +L EE
Sbjct: 1184 GERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSAC-RLTTQCELLTQLRSAQEEEN 1242
Query: 766 QGPLP--RGSQRSEQLELERALKLQP-CASEKRAQMCVSLALEEEELELARGKRVDGPSL 822
+ L + R + LER+L+ + E+R + AL E+ +L +++
Sbjct: 1243 RQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLV--EKIMDQYR 1300
Query: 823 EAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPG-DGRESEEAAGAGPRRRQ 881
E LP+ + + R + P R G P L G DG S E+ G P
Sbjct: 1301 VLEPVPLPRTKKGSWLADKVKRLMRPRREG---GPPGGLRLGADGAGSTESLGGPPETEL 1357
Query: 882 AQDTEATQSPAPAPAP--------------ASHGPSERWSRMQPCGVDGD---------- 917
+ EA + +P+PAP + G + S P G +
Sbjct: 1358 PEGREADGTGSPSPAPMRRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQ 1417
Query: 918 -IVPKEPEPFGASAAGLEQPGA----RELPLLGTERDASQTQPRMWEPPLRP 964
+ P P GA + + PG L E DA++ P + EP RP
Sbjct: 1418 RFRQRHPGPLGAPVSHSKGPGVGWENSAETLQEHETDANREGPEVQEPEKRP 1469
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 80.5 bits (197), Expect = 1e-14
Identities = 85/393 (21%), Positives = 174/393 (44%), Gaps = 41/393 (10%)
Query: 992 EQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIAL 1051
E+A E+QA+ E L+ K L + L++A ++ E
Sbjct: 74 EKAGEEQAKFENQLKTKVMK----------LENELEMAQQSAGGRDTRFLRNE-----IC 118
Query: 1052 EREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAE 1111
+ EK +E K LED+ + LEK + E L EN+ L+ + R++++ E
Sbjct: 119 QLEKQ-LEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLC 177
Query: 1112 STHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNE 1171
+K+I+ KE S ++ +Y+ QLS+ N ++Q E T NE
Sbjct: 178 QDIIDYQKQID---SQKETLLSR----RGEDSDYRSQLSKKNYELIQYLDEIQTLTEANE 230
Query: 1172 EHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRV-------ELECLNQEHQSLQLPWSELTQ 1224
+ V Q + ++LEE V+ ++ +D+ +++ ++ L +E+ QL ELT
Sbjct: 231 KIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTD 290
Query: 1225 TLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLL-SLQGEQARRRLDAQREE 1283
L+ ++ + + A+ + + + D + E ++L +L+ + +LDA +
Sbjct: 291 LLKSKNEEDDPIMVAV-NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSN 349
Query: 1284 HEKQLKATEERVEEAEMILKNMEMLLQEK------VDKLKEQFEKNTKSDLLLKELYVEN 1337
+ +ER + +M+ + +E +E ++ LK + ++N + L ++ +++
Sbjct: 350 VMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMK- 408
Query: 1338 AHLVRALQATEEKQRGAEKQSRLLEEKVRALNK 1370
+ L +EK + AE+ + L E R +K
Sbjct: 409 --IQSTLDILKEKTKEAERTAELAEADAREKDK 439
Score = 51.2 bits (121), Expect = 7e-06
Identities = 83/381 (21%), Positives = 150/381 (39%), Gaps = 82/381 (21%)
Query: 346 LDFSVDEKVNLLELT-WALDNELMT-VDSAVQQAALACYHQELSYQQGQVEQLARERDKA 403
L+ D +N + T W L + T V + LA Q ++ Q + L + K
Sbjct: 1588 LELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKV 1647
Query: 404 RQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKH-----------LEQGYRERLSLLRS 452
QDLER + VKE ++ L++ E ++K L+Q +E L+S
Sbjct: 1648 SQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKES-QCLKS 1706
Query: 453 EVEAEREL-----------FWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKEN---- 497
E++A++E E+ Q A E L LR ++T A +E
Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISA 1766
Query: 498 --------------SRLQKEIVEVVEKLSDS---ERLALKLQKDLEFVLKDKLEPQSAEL 540
R +E+ VE L+++ + ALK K+ E L D L + EL
Sbjct: 1767 TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL 1826
Query: 541 LAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGL 600
+++ + +L+E E ++ NDEL+ +++ L + L
Sbjct: 1827 QKKQKAYNKILREKE----EIDQENDELKRQIKRLTSGL--------------------- 1861
Query: 601 GPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKD 660
P++ + ++E+++ + L QLE KV E ++ +K KE
Sbjct: 1862 ---------QGKPLTDNKQSLIEELQRKVKKLENQLEGKVE--EVDLKPMKEKNAKEELI 1910
Query: 661 MEQARRREVSVLEGQKADLEE 681
+ ++ + +EG + L+E
Sbjct: 1911 RWEEGKKWQAKIEGIRNKLKE 1931
Score = 45.8 bits (107), Expect = 3e-04
Identities = 73/345 (21%), Positives = 145/345 (42%), Gaps = 34/345 (9%)
Query: 1042 PEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKND-L 1100
P + +IAL + K+++ +L ++LE+ + +E+ RL+E+N L ++ +
Sbjct: 1448 PLPNQLEIALRKIKENIRI-ILETRATCKSLEEKLKEKESAL----RLAEQNILSRDKVI 1502
Query: 1101 GRVRQELEAAESTH----DAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRV 1156
+R L A + RKE+E K + + N K+++ + R+
Sbjct: 1503 NELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRL 1562
Query: 1157 LQLGQEASTHQAQNEEHRVTI--QMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQS 1214
L+ +E + E + I L + + +Q + + K N+
Sbjct: 1563 LEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIR 1622
Query: 1215 LQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRL-LSLQGEQA 1273
L +E+ QT+ E D + ++L++ +Q L+ R + + +V E + L LQ
Sbjct: 1623 L----AEMEQTVAEQDDSLSSLLVKLKKV-SQDLERQREITELKVKEFENIKLQLQ---- 1673
Query: 1274 RRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKEL 1333
E HE ++K + VE+ + +L + Q +L+ Q E N+++
Sbjct: 1674 --------ENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRN 1725
Query: 1334 YVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPA 1378
VE +++ A +EKQ+ A ++ LLE + RI A
Sbjct: 1726 LVER---LKSQLALKEKQQKALSRA-LLELRAEMTAAAEERIISA 1766
Score = 43.9 bits (102), Expect = 0.001
Identities = 59/303 (19%), Positives = 127/303 (41%), Gaps = 44/303 (14%)
Query: 1037 EQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLL 1096
E+L A + + E + E + E + + L+K D E R+ + L N +
Sbjct: 2178 EKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKM 2237
Query: 1097 KNDLGRVRQELEAAESTH------DAQRKEIEVLKKDKEKACSEMEV-LNRQNQNYKDQL 1149
L + L+ AES D++ + V+ + E E+E + ++NQ+ D
Sbjct: 2238 TVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITD-- 2295
Query: 1150 SQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLN 1209
+ QL +EA+ + + ++ ++ + L+ V + + Q L+ EL+ L
Sbjct: 2296 ------LKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETE----QGLKRELQVLR 2345
Query: 1210 QEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQ 1269
+ L +EL +E ++DQ GA + A Q
Sbjct: 2346 LANHQLDKEKAELIHQIEANKDQ-SGAESTIPDAD------------------------Q 2380
Query: 1270 GEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLL 1329
++ + L+ Q + + + + +E +++ + L+N + E+++ LK +++ K ++L
Sbjct: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNIL 2440
Query: 1330 LKE 1332
L+E
Sbjct: 2441 LEE 2443
Score = 43.5 bits (101), Expect = 0.001
Identities = 87/422 (20%), Positives = 175/422 (41%), Gaps = 114/422 (27%)
Query: 1047 TKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQE 1106
TKI L+ +K + + +++ ++ K V + DR L + LK ++ ++R+
Sbjct: 1105 TKINLDAQKVEQMLR----DELADSVSKAVS--DADRQRILELEKNEMELKVEVSKLRE- 1157
Query: 1107 LEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQ---------LSQLNVRVL 1157
D R+++E+L ++ E+E L Q +Y+ Q L Q NV L
Sbjct: 1158 ------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVS-L 1210
Query: 1158 QLGQ-------EASTHQAQNEEH------------------------------RVTIQML 1180
QL + E+ T + Q E R TIQ L
Sbjct: 1211 QLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL 1270
Query: 1181 TQSLEEVVRSGQQ----------QSDQIQKLRVELECLNQEHQSLQ----------LPWS 1220
+ + QQ Q+D++ K+ E++ QEH++++
Sbjct: 1271 RRQFSGALPLAQQEKFSKTMIQLQNDKL-KIMQEMKNSQQEHRNMENKTLEMELKLKGLE 1329
Query: 1221 ELTQTLEESQ--DQVQGAHLRLRQAQAQHLQEVRLVPQDR---------VAELHRLLSLQ 1269
EL TL++++ +V H+++ + + Q L+ R + +D+ ++E R +S
Sbjct: 1330 ELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSL 1389
Query: 1270 GEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKS--- 1326
E+ + Q + HE++ A ++R + E L + Q ++ ++FE+ T S
Sbjct: 1390 EEE----IVQQNKFHEERQMAWDQREVDLERQLDIFDR-QQNEILNAAQKFEEATGSIPD 1444
Query: 1327 ---------DLLLKELYVENAHLVRALQAT----EEKQRGAEKQSRLLEEKVRALNKLVS 1373
++ L+++ EN ++ +AT EEK + E RL E+ + + +K+++
Sbjct: 1445 PSLPLPNQLEIALRKI-KENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVIN 1503
Query: 1374 RI 1375
+
Sbjct: 1504 EL 1505
Score = 43.1 bits (100), Expect = 0.002
Identities = 71/361 (19%), Positives = 150/361 (41%), Gaps = 59/361 (16%)
Query: 1056 DDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTL----LKNDLGRVRQELEAAE 1111
D ++ ++ L+ ++ + + + ++ + E+NT LKN+L R + ++
Sbjct: 344 DADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQ 403
Query: 1112 STHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNE 1171
TH + +++LK+ ++A E+ + +L + R+ E+ +
Sbjct: 404 QTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY--ESGVY----- 456
Query: 1172 EHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQD 1231
LE+ V + +QI+ E+E L +E L+L S+ E ++
Sbjct: 457 -----------GLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRE 505
Query: 1232 QV--------------QGAHLRLRQAQAQH---LQEVRLVPQDRVAELHRLLSLQGEQAR 1274
+V HL+ +Q +A++ L+E+ + ++R+ ++ + E+ +
Sbjct: 506 RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK 565
Query: 1275 RRLDAQREEHEKQLK---ATEERVEEAE---MILKNM-------EMLLQEKVDKLKEQFE 1321
R + + L + +R+ E + + LKNM E L +E ++K ++
Sbjct: 566 RSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLER 625
Query: 1322 KNT---KSDLLLKELYVENAHLVRA----LQATEEKQRGAEKQSRLLEEKVRALNKLVSR 1374
T K LKEL EN L LQA +E Q+ + + + +L +LV+
Sbjct: 626 SRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA 685
Query: 1375 I 1375
I
Sbjct: 686 I 686
Score = 42.0 bits (97), Expect = 0.004
Identities = 75/346 (21%), Positives = 131/346 (37%), Gaps = 64/346 (18%)
Query: 1036 QEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRAL---EKHVDLRENDRLEFHR-LSE 1091
Q+ + E AL+ + D+M+ L + L EK + + +E R L +
Sbjct: 853 QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912
Query: 1092 ENTLLKNDLGRVRQELEAAESTHDAQR-KEIEVLK-------KDKEKACSEMEVLNRQ-- 1141
EN KN+L + E E E QR KE+ + K D + SE+E+ N+Q
Sbjct: 913 ENEKQKNEL--LSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYN 970
Query: 1142 --NQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQ 1199
Y+D L + N+ V + T +LE + +Q++
Sbjct: 971 ELTAKYRDILQKDNMLVQR----------------------TSNLEHLECENISLKEQVE 1008
Query: 1200 KLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRV 1259
+ ELE ++ +++ W + T+ ES + + + D V
Sbjct: 1009 SINKELEITKEKLHTIEQAWEQETKLGNES---------------SMDKAKKSITNSDIV 1053
Query: 1260 AELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQ 1319
+ ++ L+ ++ R QR EH ++ E LK ME E K E
Sbjct: 1054 SISKKITMLEMKELNER---QRAEH------CQKMYEHLRTSLKQMEERNFELETKFAEL 1104
Query: 1320 FEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKV 1365
+ N + + + L E A V + ++QR E + +E KV
Sbjct: 1105 TKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150
Score = 42.0 bits (97), Expect = 0.004
Identities = 91/453 (20%), Positives = 188/453 (41%), Gaps = 60/453 (13%)
Query: 964 PAASCRGQAERLQ---AIQEERARSWSRGTQEQASEQQARAEGAL-----EPGCHKHSVE 1015
P + R ERL+ A++E++ ++ SR E +E A AE + + H + +
Sbjct: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778
Query: 1016 VARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKH 1075
+ R + Q+ D E L +E AL+ K+ + +L D+ L+K
Sbjct: 1779 IVDRHTRELKTQVED----LNENLLKLKE-----ALKTSKNRENSLTDNLNDLNNELQKK 1829
Query: 1076 VDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQ------RKEIEVLKKDKE 1129
E + +EN LK + R+ L+ T + Q +++++ L+ E
Sbjct: 1830 QKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLE 1889
Query: 1130 KACSEMEVLNRQNQNYKDQLSQLNV-RVLQLGQEASTHQAQNEEHRV-TIQMLTQSLEEV 1187
E+++ + +N K++L + + Q E ++ + +E V T+ +L+++
Sbjct: 1890 GKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDL 1949
Query: 1188 VRSGQQQS--------------DQIQKLRV-----ELECLNQEHQSLQ--LPWSELTQTL 1226
++ DQ+ +R ELE L + + L+ + + Q L
Sbjct: 1950 FAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQAL 2009
Query: 1227 EESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEK 1286
V+ HL+ R Q +++ + + + + S+ G ++ ++E ++
Sbjct: 2010 PR-DSVVEDLHLQNRYLQ----EKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKE 2064
Query: 1287 QLKATEERVE---EAEMILKNMEMLLQEKVDKLKE--QFEKNTKSDLLLKELYVENAHLV 1341
LK + E +E + E K++ L+ +V LKE +F K K+++ K +V +
Sbjct: 2065 NLKLSSENIELKFQLEQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123
Query: 1342 RALQATEEKQRGAEKQSRLLEEKVRALNKLVSR 1374
EK G K+ + EKV+ N+ + +
Sbjct: 2124 GKTIPELEKTIGLMKK---VVEKVQRENEQLKK 2153
Score = 41.6 bits (96), Expect = 0.005
Identities = 81/356 (22%), Positives = 156/356 (43%), Gaps = 39/356 (10%)
Query: 376 QAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKK 435
QA + +L ++G+V L ++ + + +A+K L +++ T++Q+
Sbjct: 1919 QAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVL--G 1976
Query: 436 IKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALK 495
I+ LE +E L + ++ E ++ + +AH Q + V L + L+EKL K
Sbjct: 1977 IRALE-SEKELEELKKRNLDLENDILYMRAH-QALPRDSVVEDLHLQNRYLQEKLHALEK 2034
Query: 496 ENSR--LQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKE 553
+ S+ K + +E +R +LQK+ KL ++ EL Q E+ L
Sbjct: 2035 QFSKDTYSKPSISGIESDDHCQR-EQELQKE-----NLKLSSENIELKFQLEQANKDLPR 2088
Query: 554 YELKCRDLQDRNDEL---QAELEGLWARLPKNRHSPSWSPDGRR-------------RQL 597
+ + RDL++ + L +AE++ + + S P+ + R+
Sbjct: 2089 LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQREN 2148
Query: 598 PGLGPA-GISFLGNSAPVSIETELM---MEQVKEHY-QDLRTQLETKVNYYEREIAALKR 652
L A GI A + E E + +E++K H L E+K E+ IA +R
Sbjct: 2149 EQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENER 2208
Query: 653 NFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQ-DTARGPEPE 707
++ +K+ + A + ++ K +LE L+EK + ++LQ +RGP+ E
Sbjct: 2209 LRKELKKETDAAEKLRIA-----KNNLEILNEKMTVQLEETGKRLQFAESRGPQLE 2259
Score = 39.7 bits (91), Expect = 0.020
Identities = 90/420 (21%), Positives = 169/420 (40%), Gaps = 53/420 (12%)
Query: 383 HQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDD----CHSTLEQLTEKKIKH 438
HQ ++ Q ++ Q K ++ LE+A + E VK+ ++ H LE + +
Sbjct: 1539 HQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNK 1598
Query: 439 LEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENS 498
+Q + + + V + + A +E V + L KL ++
Sbjct: 1599 FKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE 1652
Query: 499 RLQKEIVEVVEKLSDSERLALKLQKDLE-FVLKDKLEPQSAE-LLAQEERFAAVLK---- 552
R Q+EI E+ K+ + E + L+LQ++ E V K K E + + LL Q ++ + LK
Sbjct: 1653 R-QREITEL--KVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQ 1709
Query: 553 -EYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNS 611
+ E R L L+ A K + + S + R ++ I S
Sbjct: 1710 AQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERII----S 1765
Query: 612 APVSIETELMMEQ-VKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVS 670
A E L ++Q V H ++L+TQ+E L N K ++ ++ ++ RE S
Sbjct: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVED-----------LNENLLKLKEALKTSKNRENS 1814
Query: 671 VLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLAL--RHHS 728
+ + EL +K + L+E+ + E ++ T L G L S
Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQ--IKRLTSGLQGKPLTDNKQS 1872
Query: 729 HLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQ 788
+++++R+ + +L +L G ++EE P+ + + E + E K Q
Sbjct: 1873 LIEELQRKVK-KLENQLEG------------KVEEVDLKPMKEKNAKEELIRWEEGKKWQ 1919
Score = 37.0 bits (84), Expect = 0.13
Identities = 49/277 (17%), Positives = 113/277 (40%), Gaps = 25/277 (9%)
Query: 1106 ELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEAST 1165
E++ ++ + +EIE+L K+ K ++ +N+ ++++ ++ L + ++
Sbjct: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
Query: 1166 HQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQT 1225
+ +++R Q+L + +E + ++ L+ ++ + QE T+
Sbjct: 524 KHLKQQQYRAENQILLKEIESL-------EEERLDLKKKIRQMAQERGKRSATSGLTTED 576
Query: 1226 LEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHE 1285
L +++ QG + R+ L + L + LS + + R L+ R
Sbjct: 577 LNLTENISQGDRISERK-----LDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIA 631
Query: 1286 KQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELY----------- 1334
K +E VEE + + + M+ +LQ + K+ K ++ L++ L
Sbjct: 632 KFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNA 691
Query: 1335 --VENAHLVRALQATEEKQRGAEKQSRLLEEKVRALN 1369
+ +A L Q + R E + L E + A+N
Sbjct: 692 EGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAIN 728
Score = 37.0 bits (84), Expect = 0.13
Identities = 49/219 (22%), Positives = 98/219 (44%), Gaps = 45/219 (20%)
Query: 384 QELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGY 443
+ +S Q + E L+RE + +DLER+ +F + L++L E+ K LE+G
Sbjct: 600 KNMSEAQSKNEFLSRELIEKERDLERSRTVIAKF-------QNKLKELVEEN-KQLEEGM 651
Query: 444 RERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEA------------------G 485
+E L ++ E++ + ++ + +LE V ++++ A G
Sbjct: 652 KEILQAIK-EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTG 710
Query: 486 LREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV--------------LKD 531
E+L L+E+ +KE + ++L+ + L+K+ + L D
Sbjct: 711 RNEELRQELRES---RKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767
Query: 532 KLEPQSAELL-AQEERFAAVLKEYELKCRDLQDRNDELQ 569
+ P SA ++ +Q E +L+E E K + L++ D L+
Sbjct: 768 GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLE 806
Score = 34.7 bits (78), Expect = 0.65
Identities = 63/362 (17%), Positives = 144/362 (39%), Gaps = 46/362 (12%)
Query: 363 LDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMD 422
L+NEL + E+ + Q+EQ RE + ++LE+ +K N + +
Sbjct: 94 LENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE 153
Query: 423 DCHSTLEQL--TEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ 480
+ + +L K++K + + + + ++++++E + +
Sbjct: 154 EAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSR---------------R 198
Query: 481 AEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEP--QSA 538
E++ R +L+ K+N L + + E+ +E++ ++ Q+ ++ LE Q
Sbjct: 199 GEDSDYRSQLS---KKNYELIQYLDEIQTLTEANEKIEVQNQE-----MRKNLEESVQEM 250
Query: 539 ELLAQE-ERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQL 597
E + E R A++ + + L+ ND Q +++ L L S + D +
Sbjct: 251 EKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL----KSKNEEDDPIMVAV 306
Query: 598 PGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQ--------LETKVNYYEREIAA 649
L + IE + M+ ++E ++ + L+ + + +I
Sbjct: 307 NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKM 366
Query: 650 LKRNFEKERKDME------QARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARG 703
L E+ K+ME + + E+ +G ++ H K Q + L+E+ ++ R
Sbjct: 367 LTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERT 426
Query: 704 PE 705
E
Sbjct: 427 AE 428
Score = 33.9 bits (76), Expect = 1.1
Identities = 62/310 (20%), Positives = 132/310 (42%), Gaps = 62/310 (20%)
Query: 1048 KIALEREKDDMETKLLHLEDV--VRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQ 1105
K+ L+R+ ++T + ++ V +RALE +L E L + N L+ND+ +R
Sbjct: 1957 KLTLQRK---LKTTGMTVDQVLGIRALESEKELEE--------LKKRNLDLENDILYMR- 2004
Query: 1106 ELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEAST 1165
H A ++ V + + ++ + Q KD S+ ++ G E+
Sbjct: 2005 -------AHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSIS----GIESDD 2053
Query: 1166 H-QAQNEEHRVTIQMLTQSLEEVVRSGQQQSD------QIQKLRVELECLNQEHQSLQLP 1218
H Q + E + +++ ++++E + Q D Q++ L+ E L +E +Q
Sbjct: 2054 HCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRK 2113
Query: 1219 WS-------------ELTQTL---EESQDQVQGAHLRLRQAQ----AQHLQEVRLVPQDR 1258
EL +T+ ++ ++VQ + +L++A ++ + + +
Sbjct: 2114 LGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKL 2173
Query: 1259 VAELHRLLSLQGEQ----------ARRRLDAQREEHEKQLKATEERVEEAEMILKNMEML 1308
AEL +L + G Q ++ A+ E K+LK + E+ + N+E+L
Sbjct: 2174 KAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEIL 2233
Query: 1309 LQEKVDKLKE 1318
++ +L+E
Sbjct: 2234 NEKMTVQLEE 2243
Score = 33.1 bits (74), Expect = 1.9
Identities = 61/274 (22%), Positives = 112/274 (40%), Gaps = 45/274 (16%)
Query: 394 EQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQ-GYRERLSLLRS 452
E++ E ++ R++L K+ + +++ + LE L EK LE+ G R + + R
Sbjct: 2200 EKIIAENERLRKEL----KKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG 2255
Query: 453 -EVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKL 511
++E W+ R E L+E T K+N + ++ ++V++
Sbjct: 2256 PQLEGADSKSWKSIVVTRMY-----------ETKLKELETDIAKKNQSIT-DLKQLVKEA 2303
Query: 512 SDSERLALKLQKDLEFVLKD-KLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQA 570
++ E+ K +DLE +K K P+ AE +R VL+ N +L
Sbjct: 2304 TEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRL----------ANHQLDK 2353
Query: 571 ELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMM-----EQV 625
E L ++ N+ G +P +ET+L M + +
Sbjct: 2354 EKAELIHQIEANKDQ-----SGAESTIPDADQL------KEKIKDLETQLKMSDLEKQHL 2402
Query: 626 KEHYQDLRTQLETKVNYYEREIAALKRNFEKERK 659
KE + L+ +LE + EI LK N+++E K
Sbjct: 2403 KEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVK 2436
Score = 31.6 bits (70), Expect = 5.5
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 9/85 (10%)
Query: 614 VSIETELMMEQVKEHYQDLR------TQLETKVNYYEREIAALKRNFEKERKDMEQ-ARR 666
+ +E EL M Q +D R QLE ++ +RE+ +++ EKE+K EQ A R
Sbjct: 92 MKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALR 151
Query: 667 REVSVLEGQKADLE--ELHEKSQEV 689
E + E K E L +K++++
Sbjct: 152 NEEAENENSKLRRENKRLKKKNEQL 176
Score = 31.6 bits (70), Expect = 5.5
Identities = 64/328 (19%), Positives = 131/328 (39%), Gaps = 47/328 (14%)
Query: 1072 LEKHVDLRENDRL------EFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLK 1125
+EK DL + + + L EEN L+ + + Q ++ + D + E ++
Sbjct: 617 IEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLII 676
Query: 1126 KDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLE 1185
E+ + +E ++ + D L +V QL +NEE L Q L
Sbjct: 677 PSLERLVNAIE--SKNAEGIFDASLHLKAQVDQL-------TGRNEE-------LRQELR 720
Query: 1186 EVVRSGQQQSDQIQKLRVELECLNQEHQSL-QLPWSELTQTLEESQDQVQGAHLRLRQAQ 1244
E + S Q+ K ++++ L +E L Q S + + D + + + +Q
Sbjct: 721 ESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQ 780
Query: 1245 AQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREE--------HEKQLKATEERVE 1296
++L + +++ +L L + R+ + ++ EK+ TE +
Sbjct: 781 NEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI 840
Query: 1297 EAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLL------LKELYVENAHLVRALQATEEK 1350
+ E + +E +Q+ K+KE N + L +K++ EN+ + LQ E+
Sbjct: 841 KEEK--RKLEDQVQQDAIKVKEY---NNLLNALQMDSDEMKKILAENSRKITVLQVNEKS 895
Query: 1351 -----QRGAEKQSRLLEEKVRALNKLVS 1373
E + +L +E + N+L+S
Sbjct: 896 LIRQYTTLVELERQLRKENEKQKNELLS 923
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 78.6 bits (192), Expect = 4e-14
Identities = 283/1312 (21%), Positives = 483/1312 (36%), Gaps = 213/1312 (16%)
Query: 111 RRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFE 170
RR +L A T + + E Q L R++ +E +E K E+ + E +
Sbjct: 468 RRLWSQLDSARTSRQELSELHEQL-----LARTSRVEDLEQLKQREKTQHESELE----- 517
Query: 171 AQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGL 230
QL+ + + +K+ + +++G E+ L E+ + C VGL
Sbjct: 518 ---QLRIYFEKKLRDAEKTYQEDLTLLQQRLQGARED------ALLDSVEVGLSC--VGL 566
Query: 231 QGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLF-SHEPAL-LLESSTRVKPSKAWSHYQV 288
+ ++ +D ++L+ + K SL FQ L SH L LES ++ S
Sbjct: 567 EEKPEKGRKDHVDELEPERH-KESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCC 625
Query: 289 PEESGC-HTTTTSSLVSLCSSLRL--FSSIDDGSGFAFPDQ---VLAMWTQEGIQNGREI 342
E S H L + DG A ++ VL + T+ +Q
Sbjct: 626 VETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQ----- 680
Query: 343 LQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDK 402
L L + E++ LL++ + ++ ++ H + Q ++ ++ +
Sbjct: 681 LSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTEL 740
Query: 403 ARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFW 462
+Q+ +R E +E+ E+LT ++ E+ E+ +++ E E+
Sbjct: 741 MKQEFQRKETDWKVMKEELQ--REAEEKLTLMLLELREKAESEKQTIINKFELREAEM-- 796
Query: 463 EQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQ-KEIVEVVEKLSDSERLALKL 521
Q Q+AA D+ R E+ G ++L L + L + D E AL +
Sbjct: 797 RQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAALHV 856
Query: 522 QKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPK 581
++D + +L+ RF KE K QD + E +L +
Sbjct: 857 KEDC-----------ALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQ 905
Query: 582 NRHSP---SWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLET 638
RH S + + R LG S S + L+ +V E L+T
Sbjct: 906 ERHQQQLLSVTAELEARHQAALGELTASL------ESKQGALLAARVAE--------LQT 951
Query: 639 KVNYYEREIAALKRNFEKERKDMEQARRREVSVL-EGQKADLEELHEKSQEVIWGLQEQL 697
K + ++ AL+ +E E + E + LE L +E +W ++ L
Sbjct: 952 K---HAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWK-KDSL 1007
Query: 698 QDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPAR--- 754
T TQ L L +H LQ +R E+S EL+G A +
Sbjct: 1008 HQTI-------------LTQELEKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVH 1054
Query: 755 --------------RDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCV 800
++ TL L+ P + + S L+L++ K K + +
Sbjct: 1055 QGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQK--KNHQVQQLKDQVLSL 1112
Query: 801 SLALEE--EELELARGKRV----DGPSLEAEMQA----------LPKDGL--VAGSGQEG 842
S +EE ELE+ + +R +G +L + ++A +D L + G E
Sbjct: 1113 SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGET 1172
Query: 843 TRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGP 902
R + LR GER L + AGAG A E T S P
Sbjct: 1173 LRAAVTLRSRIGERVGLCL---------DDAGAGLALSTAPALEETWSDVALPEL----- 1218
Query: 903 SERWSRMQPCGVDGDIVPKEPEPFGASAAGL---EQPGARELPLLGTERDASQTQPRMWE 959
S +I E F S + EQP R L D
Sbjct: 1219 DRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSS 1278
Query: 960 PPLRPAASCRGQAERLQAIQEERARSWSRGTQEQAS----EQQARAEGALEPGCHKHSVE 1015
L A + E+ + + E R QE E A+AE ALE HK
Sbjct: 1279 RQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALE--LHK---- 1332
Query: 1016 VARRGSLPSH-LQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEK 1074
+G+L ++ AD +E LA E+ E ++ LE LE + R L++
Sbjct: 1333 --TQGTLEGFKVETAD----LKEVLAGKEDSEHRLVLE------------LESLRRQLQQ 1374
Query: 1075 HVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSE 1134
+ R E RL D AE+ A RKE+E L K++ + +
Sbjct: 1375 AAQEQAALREECTRLWSRGEATATD----------AEAREAALRKEVEDLTKEQSETRKQ 1424
Query: 1135 MEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQ--AQNEEHRVTIQMLTQSLEEVVRSGQ 1192
E ++ LSQ+ + +L ++ S H+ A+ E ++ SL++ +R+ +
Sbjct: 1425 AE------KDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQR 1478
Query: 1193 QQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQA---QAQHLQ 1249
Q D+ + +EH+ EE Q ++Q +LRQA Q +
Sbjct: 1479 QFMDE--------QAAEREHER------------EEFQQEIQRLEGQLRQAAKPQPWGPR 1518
Query: 1250 EVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEE---RVEEAEMILKNME 1306
+ + P D EL + + L Q+E ++Q+ EE R+EE + ++
Sbjct: 1519 DSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKV 1578
Query: 1307 MLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQS 1358
LQE+V+K K + + +LK+ + + L LQ+T + R E S
Sbjct: 1579 AQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPS 1630
Score = 57.0 bits (136), Expect = 1e-07
Identities = 243/1170 (20%), Positives = 439/1170 (37%), Gaps = 232/1170 (19%)
Query: 123 EARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDSED 182
E R + +A + LW+ SL ++ + E + ++ + EL + L+T S +
Sbjct: 984 EEHRQALELLRADFEEQLWKKDSLH--QTILTQELEKLKRKHEGELQSVRDHLRTEVSTE 1041
Query: 183 FGSPQKSCSPSFDTPESQIRGVWE-ELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDL 241
T +++GV + E G L E+E + QS Q +EE E L
Sbjct: 1042 LAG----------TVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESL 1091
Query: 242 FNKLDQDGDGKVSLEEFQLGLFSHEPA-------LLLESSTR-----------VKPSKAW 283
+L + L++ L L SHE +L + R +K
Sbjct: 1092 SLQLQKKNHQVQQLKDQVLSL-SHEIEECRSELEVLQQRRERENREGANLLSMLKADVNL 1150
Query: 284 SHYQVPEESGCHTTTTSSLVSLC-----SSLRLFSSIDDGSGFAFPDQV--LAMWTQEGI 336
SH E G L+ L +++ L S I + G D LA+ T +
Sbjct: 1151 SH----SERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALSTAPAL 1206
Query: 337 QN--GREILQSLDFSVDEKVNLLEL----TWALDNELMTVDSAVQ-QAALACYHQELSYQ 389
+ L LD ++ E + + + ++ LM+ +S + + + Q LS
Sbjct: 1207 EETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQPIRRVFQSLSLA 1266
Query: 390 QGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSL 449
+ ++A D +RQ LE A + + F KE + Q+ K ++E L
Sbjct: 1267 VDGLMEMAL--DSSRQ-LEEARQIHSRFEKEFSFKNEETAQVVRK--------HQELLEC 1315
Query: 450 LRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVE 509
L+ E A+ EL E H+ + LE + E A L+E LA KE+S
Sbjct: 1316 LKEESAAKAELALE-LHKTQGTLEG----FKVETADLKE--VLAGKEDSE---------- 1358
Query: 510 KLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQ 569
RL L+L+ L+ +L+ + E A E + E D + R L+
Sbjct: 1359 -----HRLVLELES-----LRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALR 1408
Query: 570 AELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHY 629
E+E L + R Q+ L E+EL EQ+ +H
Sbjct: 1409 KEVEDLTKEQSETRKQAEKDRSALLSQMKIL----------------ESELE-EQLSQH- 1450
Query: 630 QDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEV 689
+ Q E V E+++A+L ++ +R+ M++ Q A+ E E+ Q+
Sbjct: 1451 RGCAKQAEA-VTALEQQVASLDKHLRNQRQFMDE-----------QAAEREHEREEFQQE 1498
Query: 690 IWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLG 749
I L+ QL+ A+ P+ G L G LQQ RE E + EL+ +
Sbjct: 1499 IQRLEGQLRQAAK---PQPWGPRDSQQAPLDGEV----ELLQQKLREKLDEFN-ELA-IQ 1549
Query: 750 ALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEEL 809
A R + ++ EE +R E++ + K+ E Q + LE+++
Sbjct: 1550 KESADRQVLMQEEE---------IKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDK- 1599
Query: 810 ELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRES 869
E+ + +++ L + +Q+ L AG C E P +P +G E
Sbjct: 1600 EVLKKQQMSSLLLASTLQST----LDAGR--------------CPEPPSG--SPPEGPEI 1639
Query: 870 E-EAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGA 928
+ E RR+++ + E+ +M+ GD+ K E
Sbjct: 1640 QLEVTQRALLRRESEVLDL---------------KEQLEKMK-----GDLESKNEEILHL 1679
Query: 929 SAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSR 988
+ +L + ++ S + L+ + + E L+A E + R
Sbjct: 1680 NL---------KLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKATIENLQENQKR 1730
Query: 989 GTQEQASEQQARAEGALEPGCHK--------HSVEVARRGSLPSHLQLADPQGSWQEQLA 1040
+E+A E + E +E H+ H V ++ GSL S L + G + L
Sbjct: 1731 LQKEKAEEIEQLHE-VIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQAL- 1788
Query: 1041 APEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDL 1100
+GE + ALE ++ AL + L+++ L
Sbjct: 1789 ---QGELEAALEAKE---------------ALSR-------------LLADQERRHSQAL 1817
Query: 1101 GRVRQELEAAESTHDAQRKEIE----VLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRV 1156
++Q L+ AE + Q E+E + + + E S ++ + + +++ N+ +
Sbjct: 1818 EALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877
Query: 1157 LQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQ 1216
L Q + H A+ E + + + ++LE+ + ++Q LR + L+++ Q L
Sbjct: 1878 DALNQRKAAHSAELEAVLLALARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLH 1937
Query: 1217 LPWSELTQTLEESQDQVQGAHLRLRQAQAQ 1246
+ L+ Q + AH R+ A Q
Sbjct: 1938 QRFLRCQVELDRRQARRATAHTRVPGAHPQ 1967
Score = 56.6 bits (135), Expect = 2e-07
Identities = 227/1016 (22%), Positives = 378/1016 (37%), Gaps = 201/1016 (19%)
Query: 357 LELTWA-LDNELMTVDSAVQQAALACYHQELSYQQGQV--------EQLARERDKA---- 403
LELT A L E T + +++ + QEL+ Q + EQ ARE+++
Sbjct: 262 LELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRC 321
Query: 404 -RQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFW 462
++ E EK E K + E +K LE +E + +SE+E + F
Sbjct: 322 GQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQ 381
Query: 463 EQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQ 522
++ QRA LE E LR S Q I ++ E L L
Sbjct: 382 KELAEQRAELEKIFQDKNQAERALRNL-------ESHHQAAIEKLREDLQSEHGRCL--- 431
Query: 523 KDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKN 582
+DLEF K+ + + EL E A +D + Q E+ LW++L
Sbjct: 432 EDLEFKFKESEKEKQLEL----ENLQA----------SYEDLKAQSQEEIRRLWSQLDSA 477
Query: 583 RHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEH---YQDLRTQLETK 639
R S R++L L L ++ V +L + +H + LR E K
Sbjct: 478 RTS--------RQELSELHE---QLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKK 526
Query: 640 V----NYYEREIAALKRNFEKERKDM------------------EQARRREVSVLEGQK- 676
+ Y+ ++ L++ + R+D E+ R+ V LE ++
Sbjct: 527 LRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERH 586
Query: 677 --------ADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRH-- 726
A+LEE H E L+ L G ++ CC + AL H
Sbjct: 587 KESLPRFQAELEESHRHQLE---ALESPLCIQHEGHVSDR-----CCVET---SALGHEW 635
Query: 727 -------HS------HLQQIR---REAEAELSGELSGLGALPARRDLTLELEEPPQGPLP 770
HS HLQ ++ EA+ E + + GL + L+ E + L
Sbjct: 636 RLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELL 695
Query: 771 RGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQ--- 827
+ R+ +L+ +L+ + + + +E+ + EL K+ ++ E Q
Sbjct: 696 KIENRNLYGKLQHETRLKDDLEKVKHNL-----IEDHQKELNNAKQ-KTELMKQEFQRKE 749
Query: 828 ---ALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQD 884
+ K+ L + ++ T LL LR + + RE+E RQ QD
Sbjct: 750 TDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAE--------MRQLQD 801
Query: 885 TEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGAR--ELP 942
+A Q +E+ R+Q ++ D+ + S G E P A+ EL
Sbjct: 802 QQAAQI-----LDLERSLTEQQGRLQQ--LEQDLT--SDDALHCSQCGREPPTAQDGELA 852
Query: 943 LLGTERDAS----QTQPRMWEPPLRPAASCRGQAER---LQAIQEERARSWSRGTQEQAS 995
L + D + + R E R + + AE+ LQ QE+ AR QE+
Sbjct: 853 ALHVKEDCALQLMLARSRFLEE--RKEITEKFSAEQDAFLQEAQEQHARELQL-LQERHQ 909
Query: 996 EQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREK 1055
+Q LE +H A G L + L+ S Q L A E + +
Sbjct: 910 QQLLSVTAELEA---RHQ---AALGELTASLE------SKQGALLAARVAELQTKHAADL 957
Query: 1056 DDMETKLLHLEDVVRA--LEKHVDLRENDR--LEFHRLSEENTLLKNDLGR---VRQELE 1108
+ET+ L D + + L + +RE R LE R E L K D + QELE
Sbjct: 958 GALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELE 1017
Query: 1109 AAESTHDAQRKEI------EVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRV----LQ 1158
+ H+ + + + EV + E++ ++ Q + ++ + L+ + LQ
Sbjct: 1018 KLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVH-QGEFGSEKKTALHEKEETLRLQ 1076
Query: 1159 LGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLP 1218
Q HQ + E + +Q ++++ S +I++ R ELE L Q +
Sbjct: 1077 SAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136
Query: 1219 WSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQAR 1274
+ L L+ A + L ++ LQ+ L RLL L GE R
Sbjct: 1137 GANLLSMLK--------ADVNLSHSERGALQDA----------LRRLLGLFGETLR 1174
Score = 51.6 bits (122), Expect = 5e-06
Identities = 243/1153 (21%), Positives = 437/1153 (37%), Gaps = 240/1153 (20%)
Query: 375 QQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEK 434
++ AL + L+ ++ Q L + R + +L R E+ E + + C +L EK
Sbjct: 273 KETALTELREMLNSRRAQELALLQSRQQHELELLR-EQHAREKEEVVLRCGQEAAELKEK 331
Query: 435 KIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLAL 494
+E+ + + L+ + E+E++L E ++ +A + Q+E L+ +
Sbjct: 332 LQSEMEKN-AQIVKTLKEDWESEKDLCLENLRKELSA------KHQSEMEDLQNQFQ--- 381
Query: 495 KENSRLQKEIVEVVEKLSDSERLALKLQKDLEFV---LKDKLEPQSAELLAQEE-RFAAV 550
KE + + E+ ++ + + +ER L+ + L++ L+ + L E +F
Sbjct: 382 KELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKES 441
Query: 551 LKEYELKCRDLQDRNDELQA----ELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGIS 606
KE +L+ +LQ ++L+A E+ LW++L R S R++L L
Sbjct: 442 EKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS--------RQELSELHE---Q 490
Query: 607 FLGNSAPVSIETELMMEQVKEH---YQDLRTQLETKVN----YYEREIAALKRNFEKERK 659
L ++ V +L + +H + LR E K+ Y+ ++ L++ + R+
Sbjct: 491 LLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGARE 550
Query: 660 DM------------------EQARRREVSVLEGQK---------ADLEELHEKSQEVIWG 692
D E+ R+ V LE ++ A+LEE H E
Sbjct: 551 DALLDSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEA--- 607
Query: 693 LQEQLQDTARGPEPEQMGLAPCCTQALCGLALRH---------HS------HLQQIRR-- 735
L+ L G ++ CC + AL H HS HLQ ++
Sbjct: 608 LESPLCIQHEGHVSDR-----CCVETS---ALGHEWRLEPSEGHSQELPWVHLQGVQDGD 659
Query: 736 -EAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEK 794
EA+ E + + GL + L+ E + L + R+ +L+ +L+ +
Sbjct: 660 LEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKV 719
Query: 795 RAQMCVSLALEEEELELARGKRVDGPSLEAEMQA------LPKDGLVAGSGQEGTRGLLP 848
+ + +E+ + EL K+ ++ E Q + K+ L + ++ T LL
Sbjct: 720 KHNL-----IEDHQKELNNAKQKT-ELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLE 773
Query: 849 LRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSR 908
LR + + RE+E RQ QD +A Q +E+ R
Sbjct: 774 LREKAESEKQTIINKFELREAE--------MRQLQDQQAAQI-----LDLERSLTEQQGR 820
Query: 909 MQPCGVDGDIVPKEPEPFGASAAGLEQPGAR--ELPLLGTERDASQ----TQPRMWEPPL 962
+Q ++ D+ + S G E P A+ EL L + D + + R E
Sbjct: 821 LQQ--LEQDLT--SDDALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEE-- 874
Query: 963 RPAASCRGQAER---LQAIQEERARSWS----RGTQEQAS---EQQARAEGALEPGCHKH 1012
R + + AE+ LQ QE+ AR R Q+ S E +AR + AL G
Sbjct: 875 RKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAAL--GELTA 932
Query: 1013 SVEVARRGSLPSHLQLADPQGSWQEQLAAPE---------------------EGETKIAL 1051
S+E +++G+L + ++A+ Q L A E E + AL
Sbjct: 933 SLE-SKQGALLA-ARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQAL 990
Query: 1052 EREKDDMETKL-----LHLEDVVRALEKHVDLREND--RLEFHRLSEENTLLKNDLGRVR 1104
E + D E +L LH + + LEK E + + H +E +T L G V
Sbjct: 991 ELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRTEVSTELA---GTVA 1047
Query: 1105 QELEAAESTHDAQRKEIEVLKKD-----------------KEKACSEMEVLNRQNQNYKD 1147
EL+ K+ + +K+ KE +++ N Q Q KD
Sbjct: 1048 HELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSLQLQKKNHQVQQLKD 1107
Query: 1148 QLSQLNVRVLQLGQEASTHQAQNE-EHRVTIQMLTQSLEEVVRSGQQQS---DQIQKL-- 1201
Q+ L+ + + E Q + E E+R +L+ +V S ++ D +++L
Sbjct: 1108 QVLSLSHEIEECRSELEVLQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLG 1167
Query: 1202 ------------------RVELECLNQEHQSLQLP--------WS-----ELTQTLEESQ 1230
RV L CL+ L L WS EL +TL E
Sbjct: 1168 LFGETLRAAVTLRSRIGERVGL-CLDDAGAGLALSTAPALEETWSDVALPELDRTLSECA 1226
Query: 1231 DQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKA 1290
+ A + + H++E L+ + V E + + + +D E
Sbjct: 1227 EMSSVAEI------SSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLME----MALD 1276
Query: 1291 TEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEK 1350
+ ++EEA I E K ++ + K+ + LKE A L L T+
Sbjct: 1277 SSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGT 1336
Query: 1351 QRGAEKQSRLLEE 1363
G + ++ L+E
Sbjct: 1337 LEGFKVETADLKE 1349
Score = 50.4 bits (119), Expect = 1e-05
Identities = 77/323 (23%), Positives = 136/323 (42%), Gaps = 44/323 (13%)
Query: 1050 ALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEA 1109
AL +M T L L EK L E + R ++E LL++ R + ELE
Sbjct: 249 ALRLSLSNMHTAQLELTQANLQKEKETALTELREMLNSRRAQELALLQS---RQQHELEL 305
Query: 1110 AESTHDAQRKEI------------EVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVL 1157
H +++E+ E L+ + EK ++ L ++ KD + + L
Sbjct: 306 LREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKEL 365
Query: 1158 QLGQEASTHQAQNE------EHRVTIQMLTQSLEEVVRSGQQQSDQ----IQKLRVELEC 1207
++ QN+ E R ++ + Q + R+ + I+KLR +L+
Sbjct: 366 SAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQ- 424
Query: 1208 LNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLS 1267
EH +L +ES+ + Q L L QA + ++++ Q+ E+ RL S
Sbjct: 425 --SEHGRCL---EDLEFKFKESEKEKQ---LELENLQASY-EDLKAQSQE---EIRRLWS 472
Query: 1268 LQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSD 1327
Q + AR E HE QL A RVE+ E + + + + ++++L+ FEK +
Sbjct: 473 -QLDSARTSRQELSELHE-QLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRD- 529
Query: 1328 LLLKELYVENAHLV-RALQATEE 1349
++ Y E+ L+ + LQ E
Sbjct: 530 --AEKTYQEDLTLLQQRLQGARE 550
Score = 47.8 bits (112), Expect = 7e-05
Identities = 63/288 (21%), Positives = 125/288 (43%), Gaps = 28/288 (9%)
Query: 1098 NDLGRVRQELEAAEST----HDAQRKEIEVLK-KDKEKACSEMEVLNRQNQNYKDQLSQL 1152
+DLG LE E D Q K +E L+ D+ SE++ L Q + Q +Q
Sbjct: 2479 SDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQ-NQE 2537
Query: 1153 NVRVLQLGQEASTHQAQNEEHRVTIQM------------LTQSLEEVVRSGQQQSDQIQK 1200
++ L+ ++ + +EH++ Q+ + L++ + Q++++ +QK
Sbjct: 2538 KLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQK 2597
Query: 1201 LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVA 1260
L + + ++ +S + ++ L S +VQ L+LR + E++ Q+ +
Sbjct: 2598 LLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELES 2657
Query: 1261 ELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF 1320
E + +LQ + L+ ++ H ++ + + +EE L+ LK +
Sbjct: 2658 EQGKGRALQSQ-----LEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHE- 2711
Query: 1321 EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRAL 1368
T D L KEL +E++ L +E+ + +E Q L EK R L
Sbjct: 2712 --QTAKDNLQKELRIEHSRCEALL--AQERSQLSELQKDLAAEKSRTL 2755
Score = 46.6 bits (109), Expect = 2e-04
Identities = 56/223 (25%), Positives = 99/223 (44%), Gaps = 34/223 (15%)
Query: 352 EKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKA---RQDLE 408
EK LEL+ AL +E + + Q+ AC HQ+ +++L E+ + + LE
Sbjct: 2750 EKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLE 2809
Query: 409 RAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQ 468
+ +++ L HS +QL + KH E RE+ EV A + E H Q
Sbjct: 2810 KVQQQAL---------HSQ-QQLEAEAQKHCEALRREK------EVSATLKSTVEALHTQ 2853
Query: 469 RAALEWDVGRLQAEEAGLREKL-----TLALKENSRLQKEIVEVVEKLSDSERLALKLQK 523
+ L + R + + A L+ +L L +E + + E + + +E+ K Q+
Sbjct: 2854 KRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR-KWQR 2912
Query: 524 DLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND 566
D K+KL EL Q +R +K+ + RDL+ +++
Sbjct: 2913 D-----KEKLR----ELELQRQRDLHKIKQLQQTVRDLESKDE 2946
Score = 45.1 bits (105), Expect = 5e-04
Identities = 65/270 (24%), Positives = 113/270 (41%), Gaps = 69/270 (25%)
Query: 1106 ELEAAE----STHDAQRKEIEV-LKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLG 1160
ELEA + H AQ + + L+K+KE A +E+ ++ L+ + L L
Sbjct: 246 ELEALRLSLSNMHTAQLELTQANLQKEKETALTEL----------REMLNSRRAQELALL 295
Query: 1161 QEASTHQAQ--NEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLP 1218
Q H+ + E+H + E V+R GQ+ ++ +KL+ E+E Q ++L+
Sbjct: 296 QSRQQHELELLREQHA------REKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKED 349
Query: 1219 W-SELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRL 1277
W SE LE + ++ H Q++ + LQ Q ++ L
Sbjct: 350 WESEKDLCLENLRKELSAKH----QSEMEDLQN---------------------QFQKEL 384
Query: 1278 DAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVEN 1337
QR E EK + + AE L+N+E Q ++KL+E +
Sbjct: 385 AEQRAELEKIFQDKNQ----AERALRNLESHHQAAIEKLREDLQSEHG------------ 428
Query: 1338 AHLVRALQATEEKQRGAEKQSRLLEEKVRA 1367
R L+ E K + +EK+ +L E ++A
Sbjct: 429 ----RCLEDLEFKFKESEKEKQLELENLQA 454
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,191,173
Number of Sequences: 37866
Number of extensions: 2776363
Number of successful extensions: 24966
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 305
Number of HSP's successfully gapped in prelim test: 1317
Number of HSP's that attempted gapping in prelim test: 13550
Number of HSP's gapped (non-prelim): 7998
length of query: 1382
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1267
effective length of database: 13,892,928
effective search space: 17602339776
effective search space used: 17602339776
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.