Search of human proteins with 55743138

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
         (766 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is...  1532   0.0  
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso...  1526   0.0  
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a...   983   0.0  
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b...   729   0.0  
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   543   e-154
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   541   e-154
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   538   e-153
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   535   e-152
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   534   e-151
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   520   e-147
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   336   5e-92
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   334   2e-91
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       269   6e-72
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      269   6e-72
gi|4502023 AKT2 kinase [Homo sapiens]                                 266   5e-71
gi|62241015 AKT1 kinase [Homo sapiens]                                262   8e-70
gi|62241013 AKT1 kinase [Homo sapiens]                                262   8e-70
gi|62241011 AKT1 kinase [Homo sapiens]                                262   8e-70
gi|133908623 protein kinase C, iota [Homo sapiens]                    261   2e-69
gi|28557781 protein kinase C, eta [Homo sapiens]                      258   2e-68
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   258   2e-68
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   258   2e-68
gi|4506067 protein kinase C, alpha [Homo sapiens]                     257   2e-68
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   250   4e-66
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   250   4e-66
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   250   4e-66
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   250   4e-66
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           249   5e-66
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           248   1e-65
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           248   1e-65

>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform b [Homo sapiens]
          Length = 766

 Score = 1532 bits (3967), Expect = 0.0
 Identities = 766/766 (100%), Positives = 766/766 (100%)

Query: 1   MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
           MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK
Sbjct: 1   MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60

Query: 61  LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
           LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG
Sbjct: 61  LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120

Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
           GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF
Sbjct: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180

Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
           GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL
Sbjct: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240

Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
           EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300

Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
           FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360

Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCR 420
           FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCR
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCR 420

Query: 421 RCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELL 480
           RCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELL
Sbjct: 421 RCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELL 480

Query: 481 RGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP 540
           RGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP
Sbjct: 481 RGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP 540

Query: 541 VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQ 600
           VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQ
Sbjct: 541 VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQ 600

Query: 601 VPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLE 660
           VPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLE
Sbjct: 601 VPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLE 660

Query: 661 GLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAP 720
           GLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAP
Sbjct: 661 GLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAP 720

Query: 721 LAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 766
           LAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Sbjct: 721 LAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 766


>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform a [Homo sapiens]
          Length = 772

 Score = 1526 bits (3950), Expect = 0.0
 Identities = 766/772 (99%), Positives = 766/772 (99%), Gaps = 6/772 (0%)

Query: 1   MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
           MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK
Sbjct: 1   MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60

Query: 61  LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
           LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG
Sbjct: 61  LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120

Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
           GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF
Sbjct: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180

Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
           GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL
Sbjct: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240

Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
           EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300

Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
           FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360

Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM------QQYELDLREPALGQG 414
           FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM      QQYELDLREPALGQG
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420

Query: 415 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 474
           SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY
Sbjct: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480

Query: 475 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 534
           LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD
Sbjct: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 540

Query: 535 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 594
           DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY
Sbjct: 541 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 600

Query: 595 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 654
           MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA
Sbjct: 601 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660

Query: 655 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 714
           KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK
Sbjct: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 720

Query: 715 SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 766
           SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Sbjct: 721 SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 772


>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
           [Homo sapiens]
          Length = 802

 Score =  983 bits (2542), Expect = 0.0
 Identities = 493/773 (63%), Positives = 604/773 (78%), Gaps = 12/773 (1%)

Query: 2   GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
           G +  ++   V+  +  ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK  GHD GKL
Sbjct: 18  GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77

Query: 62  YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
           YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 78  YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137

Query: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
           E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197

Query: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
           LSKEF+ +E ER +SFCGTIEYMAP+I+R   +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257

Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
           +GE+N+QAE+SRRILK  PP+P  +  +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317

Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
           FQ ++W  LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP   P   + ++FQGYS
Sbjct: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376

Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM------QQYELDLREPALGQG 414
           FVAPSILF  N AV+ D L+     +RPG   VARSAMM      Q Y+LDL++  LG+G
Sbjct: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435

Query: 415 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 474
           SFS+CR+C  ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495

Query: 475 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 534
           LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPEN+L+ D
Sbjct: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPENLLFTD 554

Query: 535 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 594
           +     +KIIDFGFARL+P     P++TPCFTL YAAPELL Q GYDESCDLWSLGVILY
Sbjct: 555 ENDNLEIKIIDFGFARLKPPD-NQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILY 613

Query: 595 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 654
            MLSGQVPFQ        + A EIM KI++G FS +GEAW+ VS+EAK+L++GLLTVDP 
Sbjct: 614 TMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPN 673

Query: 655 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 714
           KRLK+ GLR + WLQDGS  SS PL TPD+L SSG AV + + ATF AFN+ KREGF L+
Sbjct: 674 KRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQ 733

Query: 715 SVENAPLAKRRKQKLRS-ATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 766
           +V+ APLAKRRK K  S +T +R  S   ++   +    K  P +   P  P+
Sbjct: 734 NVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPA 786


>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
           [Homo sapiens]
          Length = 549

 Score =  729 bits (1882), Expect = 0.0
 Identities = 357/534 (66%), Positives = 436/534 (81%), Gaps = 10/534 (1%)

Query: 2   GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
           G +  ++   V+  +  ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK  GHD GKL
Sbjct: 18  GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77

Query: 62  YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
           YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 78  YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137

Query: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
           E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197

Query: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
           LSKEF+ +E ER +SFCGTIEYMAP+I+R   +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257

Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
           +GE+N+QAE+SRRILK  PP+P  +  +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317

Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
           FQ ++W  LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP   P   + ++FQGYS
Sbjct: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376

Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM------QQYELDLREPALGQG 414
           FVAPSILF  N AV+ D L+     +RPG   VARSAMM      Q Y+LDL++  LG+G
Sbjct: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435

Query: 415 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 474
           SFS+CR+C  ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495

Query: 475 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPE 528
           LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPE
Sbjct: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPE 548



 Score =  110 bits (275), Expect = 5e-24
 Identities = 77/259 (29%), Positives = 137/259 (52%), Gaps = 23/259 (8%)

Query: 411 LGQGSFS---VCRRCRQRQSGQEFAVKILSR-------RLEANTQREVAALRLCQSHPNV 460
           LG G++    + R+     +G+ +A+K+L +       +   +T+ E   L   +  P +
Sbjct: 55  LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114

Query: 461 VNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGV 520
           V LH     +   +L+L+ + GGEL  H+ ++  F+E E    +  +V A+  +H+  G+
Sbjct: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHK-LGI 173

Query: 521 VHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELL--AQQ 578
           ++RD+K ENIL   D+ G  V + DFG ++           + C T++Y AP+++     
Sbjct: 174 IYRDIKLENILL--DSNGHVV-LTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDS 230

Query: 579 GYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVS 638
           G+D++ D WSLGV++Y +L+G  PF   +  G ++  AEI  +I +     +    Q +S
Sbjct: 231 GHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKS----EPPYPQEMS 283

Query: 639 EEAKELVRGLLTVDPAKRL 657
             AK+L++ LL  DP KRL
Sbjct: 284 ALAKDLIQRLLMKDPKKRL 302


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  543 bits (1400), Expect = e-154
 Identities = 315/733 (42%), Positives = 437/733 (59%), Gaps = 37/733 (5%)

Query: 5   DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
           D DE    E+ IT     G  EK    +FELLKVLG G++GKVFLVRK    D+G LYAM
Sbjct: 44  DSDEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAM 102

Query: 65  KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
           KVL+KA L  R + +  T+ ER +L  V   PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 103 KVLKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLF 159

Query: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
           T L +   F E +V+ Y  E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSK
Sbjct: 160 TRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK 219

Query: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
           E +  EK + +SFCGT+EYMAPE++ ++ GH  + DWWS G+L+FE+LTG+ PF    + 
Sbjct: 220 EAIDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QG 273

Query: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
             + E    ILK     P  +   AQ LL+ L  ++P  RLG+GP GA+E++ H F+  +
Sbjct: 274 KDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 333

Query: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
           DW  L  R+I  PF+P +    D   F  EFT   P  SP   P  G  ++F+G+SFVA 
Sbjct: 334 DWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAT 393

Query: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELD--LREPALGQGSFSVCRRC 422
            ++ D       DG   P A   P  + V +         D  + +  +G GS+S C+RC
Sbjct: 394 GLMED-------DG--KPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRC 444

Query: 423 RQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRG 482
             + +  E+AVK++ +  + +   E+  L     HPN++ L +V+ D  H YLV EL+RG
Sbjct: 445 VHKATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRG 503

Query: 483 GELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP-- 540
           GELL+ I +++ FSE EAS +L ++   V ++H + GVVHRDLKP NILY D++ G P  
Sbjct: 504 GELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-GNPEC 561

Query: 541 VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQ 600
           ++I DFGFA+      G+ + TPC+T  + APE+L +QGYDE CD+WSLG++LY ML+G 
Sbjct: 562 LRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGY 620

Query: 601 VPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLE 660
            PF      G      EI+ +I  G+F+L G  W  VSE AK+LV  +L VDP +RL  +
Sbjct: 621 TPF----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAK 676

Query: 661 GLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAP 720
            +    W+          L   D+       V+  + AT+ A N  K     LK +E++ 
Sbjct: 677 QVLQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPIESSI 730

Query: 721 LAKRRKQKLRSAT 733
           LA+RR +KL S T
Sbjct: 731 LAQRRVRKLPSTT 743


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  541 bits (1394), Expect = e-154
 Identities = 314/731 (42%), Positives = 436/731 (59%), Gaps = 37/731 (5%)

Query: 7   DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
           DE    E+ IT     G  EK    +FELLKVLG G++GKVFLVRK    D+G LYAMKV
Sbjct: 37  DEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 95

Query: 67  LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
           L+KA L  R + +  T+ ER +L  V   PF+V LHYAFQT+ KL+LILD++ GG++FT 
Sbjct: 96  LKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLFTR 152

Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186
           L +   F E +V+ Y  E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSKE 
Sbjct: 153 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212

Query: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246
           +  EK + +SFCGT+EYMAPE++ ++ GH  + DWWS G+L+FE+LTG+ PF    +   
Sbjct: 213 IDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QGKD 266

Query: 247 QAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDW 306
           + E    ILK     P  +   AQ LL+ L  ++P  RLG+GP GA+E++ H F+  +DW
Sbjct: 267 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 326

Query: 307 VALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSI 366
             L  R+I  PF+P +    D   F  EFT   P  SP   P  G  ++F+G+SFVA  +
Sbjct: 327 NKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGL 386

Query: 367 LFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELD--LREPALGQGSFSVCRRCRQ 424
           + D       DG   P A   P  + V +         D  + +  +G GS+S C+RC  
Sbjct: 387 MED-------DG--KPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVH 437

Query: 425 RQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGE 484
           + +  E+AVK++ +  + +   E+  L     HPN++ L +V+ D  H YLV EL+RGGE
Sbjct: 438 KATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGE 496

Query: 485 LLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP--VK 542
           LL+ I +++ FSE EAS +L ++   V ++H + GVVHRDLKP NILY D++ G P  ++
Sbjct: 497 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-GNPECLR 554

Query: 543 IIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVP 602
           I DFGFA+      G+ + TPC+T  + APE+L +QGYDE CD+WSLG++LY ML+G  P
Sbjct: 555 ICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 613

Query: 603 FQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGL 662
           F      G      EI+ +I  G+F+L G  W  VSE AK+LV  +L VDP +RL  + +
Sbjct: 614 F----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQV 669

Query: 663 RGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA 722
               W+          L   D+       V+  + AT+ A N  K     LK +E++ LA
Sbjct: 670 LQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPIESSILA 723

Query: 723 KRRKQKLRSAT 733
           +RR +KL S T
Sbjct: 724 QRRVRKLPSTT 734


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  538 bits (1386), Expect = e-153
 Identities = 317/740 (42%), Positives = 444/740 (60%), Gaps = 39/740 (5%)

Query: 1   MGDED----DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGH 56
           MG+E+     +E    E+ IT     GHE K     FELLKVLG G++GKVFLV+K  G 
Sbjct: 33  MGEEEINPQTEEVSIKEIAITHHVKEGHE-KADPSQFELLKVLGQGSFGKVFLVKKISGS 91

Query: 57  DAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILD 116
           DA +LYAMKVL+KA L  R + +  T+ ER +L  V   PF+V LHYAFQT+ KL+LILD
Sbjct: 92  DARQLYAMKVLKKATLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILD 148

Query: 117 YVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIV 176
           ++ GG++FT L +   F E +V+ Y  E+ LAL+HLH LGIIYRDLK EN+LLD EGHI 
Sbjct: 149 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 208

Query: 177 LTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGAS 236
           LTDFGLSKE +  EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG  
Sbjct: 209 LTDFGLSKESIDHEK-KAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTL 266

Query: 237 PFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVR 296
           PF    +   + E    ILK     P  + P AQ LL+ L  ++P  RLGAGP G +E++
Sbjct: 267 PF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 322

Query: 297 NHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIF 356
            H FF  +DW  L  R+I  PF+P      D   F  EFT   P  SP   P     ++F
Sbjct: 323 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLF 382

Query: 357 QGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSF 416
           +G+SFVA +   D + A+ T G+ +           + R+++      +++E  +G GS+
Sbjct: 383 RGFSFVAIT-SDDESQAMQTVGVHSI-------VQQLHRNSIQFTDGYEVKED-IGVGSY 433

Query: 417 SVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLV 476
           SVC+RC  + +  EFAVKI+ +     T+     LR  Q HPN++ L +V+ D  + Y+V
Sbjct: 434 SVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQ-HPNIITLKDVYDDGKYVYVV 492

Query: 477 LELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDT 536
            EL++GGELL+ I +++ FSE EAS +L ++   V ++H + GVVHRDLKP NILY D++
Sbjct: 493 TELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ-GVVHRDLKPSNILYVDES 551

Query: 537 PGAP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 594
            G P  ++I DFGFA+      G+ + TPC+T  + APE+L +QGYD +CD+WSLGV+LY
Sbjct: 552 -GNPESIRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLY 609

Query: 595 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 654
            ML+G  PF      G      EI+ +I  G+FSL G  W  VS+ AK+LV  +L VDP 
Sbjct: 610 TMLTGYTPF----ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPH 665

Query: 655 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 714
           +RL    +    W+          L   D    +   V+  + AT+ A NR +     L+
Sbjct: 666 QRLTAALVLRHPWIVHWDQLPQYQLNRQD----APHLVKGAMAATYSALNRNQSP--VLE 719

Query: 715 SVENAPLAKRRKQKLRSATA 734
            V  + LA+RR  K  ++TA
Sbjct: 720 PVGRSTLAQRRGIKKITSTA 739


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  535 bits (1377), Expect = e-152
 Identities = 306/731 (41%), Positives = 441/731 (60%), Gaps = 33/731 (4%)

Query: 5   DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
           +++E    E+ I+     G E K     FELLKVLG G+YGKVFLVRK  G DAG+LYAM
Sbjct: 40  EEEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 98

Query: 65  KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
           KVL+KA L  R + +  ++ ER +L  V   PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 99  KVLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLF 155

Query: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
           T L +   F E +V+ Y  E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSK
Sbjct: 156 TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK 215

Query: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
           E +  +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF  +  +
Sbjct: 216 EAIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRK 273

Query: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
            T A     ILK     P  +   AQ LL+ L  ++P  RLGAG  G +E++ HPFF  +
Sbjct: 274 ETMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329

Query: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
           DW  L  ++I  PF+P +    D  +F  EFT   P  SP   P      +F+G+SFVA 
Sbjct: 330 DWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 389

Query: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQ 424
           S++ + +   +      P      G            YE+   +  +G GS+SVC+RC  
Sbjct: 390 SLIQEPSQQDLHKVPVHPIVQQLHGN----NIHFTDGYEI---KEDIGVGSYSVCKRCVH 442

Query: 425 RQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGE 484
           + +  E+AVKI+ +  + +   E+  L     HPN++ L +V+ D    YLV+EL+RGGE
Sbjct: 443 KATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGE 501

Query: 485 LLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP--VK 542
           LL+ I ++R+FSE EAS +L ++   + ++H + GVVHRDLKP NILY D++ G+P  ++
Sbjct: 502 LLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-GSPESIR 559

Query: 543 IIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVP 602
           + DFGFA+      G+ + TPC+T  + APE+L +QGYD +CD+WSLG++LY ML+G  P
Sbjct: 560 VCDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 618

Query: 603 FQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGL 662
           F      G      EI+ +I  G+++L G  W  +S+ AK++V  +L VDP +RL    +
Sbjct: 619 F----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQV 674

Query: 663 RGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA 722
               W+ +    S   L   DV       V+  + AT+ A NR   +   L+ V ++ LA
Sbjct: 675 LKHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPVLSSNLA 728

Query: 723 KRRKQKLRSAT 733
           +RR  K  ++T
Sbjct: 729 QRRGMKRLTST 739


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  534 bits (1375), Expect = e-151
 Identities = 306/730 (41%), Positives = 440/730 (60%), Gaps = 33/730 (4%)

Query: 6   DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMK 65
           ++E    E+ I+     G E K     FELLKVLG G+YGKVFLVRK  G DAG+LYAMK
Sbjct: 33  EEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 91

Query: 66  VLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFT 125
           VL+KA L  R + +  ++ ER +L  V   PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 92  VLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFT 148

Query: 126 HLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
            L +   F E +V+ Y  E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSKE
Sbjct: 149 RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE 208

Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
            +  +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF  +  + 
Sbjct: 209 AIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKE 266

Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
           T A     ILK     P  +   AQ LL+ L  ++P  RLGAG  G +E++ HPFF  +D
Sbjct: 267 TMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTID 322

Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPS 365
           W  L  ++I  PF+P +    D  +F  EFT   P  SP   P      +F+G+SFVA S
Sbjct: 323 WNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASS 382

Query: 366 ILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQR 425
           ++ + +   +      P      G            YE+   +  +G GS+SVC+RC  +
Sbjct: 383 LIQEPSQQDLHKVPVHPIVQQLHGN----NIHFTDGYEI---KEDIGVGSYSVCKRCVHK 435

Query: 426 QSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGEL 485
            +  E+AVKI+ +  + +   E+  L     HPN++ L +V+ D    YLV+EL+RGGEL
Sbjct: 436 ATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGEL 494

Query: 486 LEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP--VKI 543
           L+ I ++R+FSE EAS +L ++   + ++H + GVVHRDLKP NILY D++ G+P  +++
Sbjct: 495 LDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-GSPESIRV 552

Query: 544 IDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPF 603
            DFGFA+      G+ + TPC+T  + APE+L +QGYD +CD+WSLG++LY ML+G  PF
Sbjct: 553 CDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPF 611

Query: 604 QGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLR 663
                 G      EI+ +I  G+++L G  W  +S+ AK++V  +L VDP +RL    + 
Sbjct: 612 ----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVL 667

Query: 664 GSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAK 723
              W+ +    S   L   DV       V+  + AT+ A NR   +   L+ V ++ LA+
Sbjct: 668 KHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPVLSSNLAQ 721

Query: 724 RRKQKLRSAT 733
           RR  K  ++T
Sbjct: 722 RRGMKRLTST 731


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  520 bits (1340), Expect = e-147
 Identities = 309/736 (41%), Positives = 435/736 (59%), Gaps = 36/736 (4%)

Query: 3   DEDDDESCAVELRITEANLTGHE----EKVSVENFELLKVLGTGAYGKVFLVRKAGGHDA 58
           +E + +SC  E  + E  +T H     EK     FELLKVLG G++GKVFLVRK  G DA
Sbjct: 39  EEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDA 98

Query: 59  GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYV 118
           G+LYAMKVL+KA+L  R + +  T+ ER +L  V   PF+V LHYAFQT+ KL+LILD++
Sbjct: 99  GQLYAMKVLKKASLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILDFL 155

Query: 119 SGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLT 178
            GG++FT L +   F E +V+ Y  E+ LAL+HLH+LGI+YRDLK EN+LLD  GHI LT
Sbjct: 156 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 215

Query: 179 DFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
           DFGLSKE + +EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG  PF
Sbjct: 216 DFGLSKESVDQEK-KAYSFCGTVEYMAPEVV-NRRGHSQSADWWSYGVLMFEMLTGTLPF 273

Query: 239 TLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNH 298
               +   + E    ILK     P  +   AQ LL+ L  ++P  RLG+  +G +E++ H
Sbjct: 274 ----QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRH 327

Query: 299 PFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQG 358
            FF  +DW  L  R++  PF+P      D   F  EFT   P  SP         ++F+G
Sbjct: 328 LFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKG 387

Query: 359 YSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSV 418
           +SFVA SI  ++    +T     P      G AA       + YEL   +  +G GS+SV
Sbjct: 388 FSFVATSIAEEYKITPITSANVLP-IVQINGNAA----QFGEVYEL---KEDIGVGSYSV 439

Query: 419 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 478
           C+RC    +  EFAVKI+ +  + +   E+  L     HPN++ L +V  D  + YLV +
Sbjct: 440 CKRCIHATTNMEFAVKIIDKS-KRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTD 498

Query: 479 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 538
           L++GGELL+ I K++ FSE EAS IL  +   V ++H + GVVHRDLKP NILY D++  
Sbjct: 499 LMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-GVVHRDLKPSNILYMDESAS 557

Query: 539 A-PVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMML 597
           A  ++I DFGFA+      G+ + TPC+T  + APE+L QQGYD +CD+WSLGV+ Y ML
Sbjct: 558 ADSIRICDFGFAKQLRGENGL-LLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTML 616

Query: 598 SGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 657
           +G  PF      G      EI+ +I  G+FSL G  W  +S+ AK+L+  +L +DP +R 
Sbjct: 617 AGYTPF----ANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRY 672

Query: 658 KLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVE 717
             E +   SW+       +   +  DV       V+  + AT+ A    K     L+ V 
Sbjct: 673 TAEQILKHSWITHRDQLPNDQPKRNDV----SHVVKGAMVATYSALTH-KTFQPVLEPVA 727

Query: 718 NAPLAKRRKQKLRSAT 733
            + LA+RR  K R++T
Sbjct: 728 ASSLAQRRSMKKRTST 743


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  336 bits (861), Expect = 5e-92
 Identities = 179/356 (50%), Positives = 242/356 (67%), Gaps = 8/356 (2%)

Query: 13  ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72
           +  I+E ++    EK+  E FELL+VLG G YGKVF VRK  G + GK++AMKVL+KA +
Sbjct: 71  KFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMI 130

Query: 73  VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
           V+ AK   HT+ ER++LE V+  PF+V L YAFQT  KL+LIL+Y+SGGE+F  L +   
Sbjct: 131 VRNAKDTAHTKAERNILEEVKH-PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 189

Query: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
           F E     Y  EI +AL HLH+ GIIYRDLK EN++L+ +GH+ LTDFGL KE +  +  
Sbjct: 190 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGT 248

Query: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252
            T +FCGTIEYMAPEI+  ++GH +AVDWWSLG L++++LTGA PFT E  + T      
Sbjct: 249 VTHTFCGTIEYMAPEIL-MRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT----ID 303

Query: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312
           +ILKC    PP +   A+DLL++LL ++   RLGAGP  A EV+ HPFF+ ++W  L AR
Sbjct: 304 KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR 363

Query: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367
           K+  PF+P ++SE DV  F  +FTR  PV SP  S       ++F G+++VAPS+L
Sbjct: 364 KVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVL 419



 Score =  110 bits (274), Expect = 6e-24
 Identities = 74/252 (29%), Positives = 128/252 (50%), Gaps = 22/252 (8%)

Query: 412 GQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQS------HPNVVNLHE 465
           G G     R+     +G+ FA+K+L + +     ++ A  +  ++      HP +V+L  
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160

Query: 466 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 525
                   YL+LE L GGEL   + ++  F E  A   L  +  A+  +H++ G+++RDL
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK-GIIYRDL 219

Query: 526 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 585
           KPENI+         VK+ DFG  +      G    T C T++Y APE+L + G++ + D
Sbjct: 220 KPENIMLNHQ---GHVKLTDFGLCK-ESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVD 275

Query: 586 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 645
            WSLG ++Y ML+G  PF G + +  ++    + CK+    +         +++EA++L+
Sbjct: 276 WWSLGALMYDMLTGAPPFTGENRK--KTIDKILKCKLNLPPY---------LTQEARDLL 324

Query: 646 RGLLTVDPAKRL 657
           + LL  + A RL
Sbjct: 325 KKLLKRNAASRL 336


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  334 bits (857), Expect = 2e-91
 Identities = 178/356 (50%), Positives = 239/356 (67%), Gaps = 8/356 (2%)

Query: 13  ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72
           E+ +TE ++    E++    FELL+VLG G YGKVF VRK  G + GK+YAMKVLRKA +
Sbjct: 47  EVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKI 106

Query: 73  VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
           V+ AK   HTR ER++LE V+  PF+V L YAFQT  KL+LIL+ +SGGE+FTHL +   
Sbjct: 107 VRNAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI 165

Query: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
           F E     Y  EI LAL HLH  GIIYRDLK EN++L S+GHI LTDFGL KE +  E  
Sbjct: 166 FLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGA 224

Query: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252
            T +FCGTIEYMAPEI+  ++GH +AVDWWSLG L++++LTG+ PFT E  + T  ++ R
Sbjct: 225 VTHTFCGTIEYMAPEIL-VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIR 283

Query: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312
             L      PP + P A+DL+++ L ++P +R+G GP  A +V+ HPFF+ ++W  L A 
Sbjct: 284 GKL----ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAW 339

Query: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367
           ++  PFRP ++SE DV  F   FTR  PV SP  +       + F G+++VAPS+L
Sbjct: 340 RVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395



 Score =  113 bits (283), Expect = 6e-25
 Identities = 76/256 (29%), Positives = 131/256 (51%), Gaps = 25/256 (9%)

Query: 411 LGQGSFSVCRRCRQRQS---GQEFAVKILSRRLEANTQREVAALRLCQS------HPNVV 461
           LG+G +    + R+ Q    G+ +A+K+L +       ++ A  R  ++      HP +V
Sbjct: 73  LGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIV 132

Query: 462 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 521
            L          YL+LE L GGEL  H+ ++  F E  A   L  +  A+  +H + G++
Sbjct: 133 ELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQ-GII 191

Query: 522 HRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD 581
           +RDLKPENI+ +       +K+ DFG  +      G    T C T++Y APE+L + G++
Sbjct: 192 YRDLKPENIMLSSQ---GHIKLTDFGLCK-ESIHEGAVTHTFCGTIEYMAPEILVRSGHN 247

Query: 582 ESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 641
            + D WSLG ++Y ML+G  PF   + +       + M KI  G+ +L       ++ +A
Sbjct: 248 RAVDWWSLGALMYDMLTGSPPFTAENRK-------KTMDKIIRGKLALP----PYLTPDA 296

Query: 642 KELVRGLLTVDPAKRL 657
           ++LV+  L  +P++R+
Sbjct: 297 RDLVKKFLKRNPSQRI 312


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  269 bits (688), Expect = 6e-72
 Identities = 141/324 (43%), Positives = 203/324 (62%), Gaps = 11/324 (3%)

Query: 22  TGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEH 81
           T H ++ ++ +F+ LK+LG G +GKV LVR+     +GK YAMK+L+K  ++ + +   H
Sbjct: 137 TTHHKRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDEVA-H 192

Query: 82  TRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVY 141
           T TE  VL+  R  PFL +L Y+FQT  +L  +++YV+GGE+F HL + + F E   R Y
Sbjct: 193 TLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFY 251

Query: 142 GGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTI 201
           G EIV AL++LH   I+YRDLKLEN++LD +GHI +TDFGL KE +T+      +FCGT 
Sbjct: 252 GAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMK-TFCGTP 310

Query: 202 EYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPF 261
           EY+APE++     +G+AVDWW LG++++E++ G  PF          ++   IL     F
Sbjct: 311 EYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHEKLFELILMEDIKF 365

Query: 262 PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQ 321
           P  +   A+ LL  LL KDP KRLG GP  A+E+  H FF G++W  +  +K+  PF+PQ
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425

Query: 322 IRSELDVGNFAEEFTRLEPVYSPP 345
           + SE D   F EEFT      +PP
Sbjct: 426 VTSETDTRYFDEEFTAQTITITPP 449



 Score =  114 bits (284), Expect = 4e-25
 Identities = 81/253 (32%), Positives = 128/253 (50%), Gaps = 23/253 (9%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           LG+G+F      R++ SG+ +A+KIL + +       A+T  E   L+  + HP + +L 
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLK 212

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                +     V+E + GGEL  H+ ++R FSE         +VSA+ ++H    +V+RD
Sbjct: 213 YSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRD 271

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK EN++   D     +KI DFG  +    +    M+T C T +Y APE+L    Y  + 
Sbjct: 272 LKLENLMLDKD---GHIKITDFGLCK-EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LGV++Y M+ G++PF     +           K+ E     D +  + +S +AK L
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQDHE-----------KLFELILMEDIKFPRTLSSDAKSL 376

Query: 645 VRGLLTVDPAKRL 657
           + GLL  DP KRL
Sbjct: 377 LSGLLIKDPNKRL 389


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  269 bits (688), Expect = 6e-72
 Identities = 141/324 (43%), Positives = 203/324 (62%), Gaps = 11/324 (3%)

Query: 22  TGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEH 81
           T H ++ ++ +F+ LK+LG G +GKV LVR+     +GK YAMK+L+K  ++ + +   H
Sbjct: 137 TTHHKRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDEVA-H 192

Query: 82  TRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVY 141
           T TE  VL+  R  PFL +L Y+FQT  +L  +++YV+GGE+F HL + + F E   R Y
Sbjct: 193 TLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFY 251

Query: 142 GGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTI 201
           G EIV AL++LH   I+YRDLKLEN++LD +GHI +TDFGL KE +T+      +FCGT 
Sbjct: 252 GAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMK-TFCGTP 310

Query: 202 EYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPF 261
           EY+APE++     +G+AVDWW LG++++E++ G  PF          ++   IL     F
Sbjct: 311 EYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHEKLFELILMEDIKF 365

Query: 262 PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQ 321
           P  +   A+ LL  LL KDP KRLG GP  A+E+  H FF G++W  +  +K+  PF+PQ
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425

Query: 322 IRSELDVGNFAEEFTRLEPVYSPP 345
           + SE D   F EEFT      +PP
Sbjct: 426 VTSETDTRYFDEEFTAQTITITPP 449



 Score =  114 bits (284), Expect = 4e-25
 Identities = 81/253 (32%), Positives = 128/253 (50%), Gaps = 23/253 (9%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           LG+G+F      R++ SG+ +A+KIL + +       A+T  E   L+  + HP + +L 
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLK 212

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                +     V+E + GGEL  H+ ++R FSE         +VSA+ ++H    +V+RD
Sbjct: 213 YSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRD 271

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK EN++   D     +KI DFG  +    +    M+T C T +Y APE+L    Y  + 
Sbjct: 272 LKLENLMLDKD---GHIKITDFGLCK-EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LGV++Y M+ G++PF     +           K+ E     D +  + +S +AK L
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQDHE-----------KLFELILMEDIKFPRTLSSDAKSL 376

Query: 645 VRGLLTVDPAKRL 657
           + GLL  DP KRL
Sbjct: 377 LSGLLIKDPNKRL 389


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  266 bits (680), Expect = 5e-71
 Identities = 139/319 (43%), Positives = 199/319 (62%), Gaps = 11/319 (3%)

Query: 27  KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
           KV++ +F+ LK+LG G +GKV LVR+      G+ YAMK+LRK  ++ + +   HT TE 
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIAKDEVA-HTVTES 201

Query: 87  SVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIV 146
            VL+  R  PFL  L YAFQT  +L  +++Y +GGE+F HL + + F E   R YG EIV
Sbjct: 202 RVLQNTRH-PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 260

Query: 147 LALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAP 206
            ALE+LH   ++YRD+KLEN++LD +GHI +TDFGL KE +++      +FCGT EY+AP
Sbjct: 261 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK-TFCGTPEYLAP 319

Query: 207 EIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIG 266
           E++     +G+AVDWW LG++++E++ G  PF           +   IL     FP  + 
Sbjct: 320 EVLED-NDYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHERLFELILMEEIRFPRTLS 374

Query: 267 PVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSEL 326
           P A+ LL  LL KDPK+RLG GP  A+EV  H FF  ++W  +  +K+  PF+PQ+ SE+
Sbjct: 375 PEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEV 434

Query: 327 DVGNFAEEFTRLEPVYSPP 345
           D   F +EFT      +PP
Sbjct: 435 DTRYFDDEFTAQSITITPP 453



 Score =  114 bits (286), Expect = 3e-25
 Identities = 82/252 (32%), Positives = 128/252 (50%), Gaps = 21/252 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQS--HPNVVNLHE 465
           LG+G+F      R++ +G+ +A+KIL + +   +      V   R+ Q+  HP +  L  
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217

Query: 466 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 525
                     V+E   GGEL  H+ ++R F+E  A      +VSA+ ++H    VV+RD+
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR-DVVYRDI 276

Query: 526 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 585
           K EN++   D     +KI DFG  +    S G  M+T C T +Y APE+L    Y  + D
Sbjct: 277 KLENLMLDKD---GHIKITDFGLCK-EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 332

Query: 586 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 645
            W LGV++Y M+ G++PF          +  E++  + E RF       + +S EAK L+
Sbjct: 333 WWGLGVVMYEMMCGRLPFYNQD----HERLFELIL-MEEIRFP------RTLSPEAKSLL 381

Query: 646 RGLLTVDPAKRL 657
            GLL  DP +RL
Sbjct: 382 AGLLKKDPKQRL 393


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  262 bits (670), Expect = 8e-70
 Identities = 144/340 (42%), Positives = 209/340 (61%), Gaps = 15/340 (4%)

Query: 7   DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
           D S A E+   E +L   + +V++  FE LK+LG G +GKV LV++      G+ YAMK+
Sbjct: 127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKI 180

Query: 67  LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
           L+K  +V + +   HT TE  VL+  R  PFL  L Y+FQT  +L  +++Y +GGE+F H
Sbjct: 181 LKKEVIVAKDEVA-HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFH 238

Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLH-KLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
           L + + F E   R YG EIV AL++LH +  ++YRDLKLEN++LD +GHI +TDFGL KE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298

Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
            + +      +FCGT EY+APE++     +G+AVDWW LG++++E++ G  PF  +    
Sbjct: 299 GIKDGATMK-TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE- 355

Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
              ++   IL     FP  +GP A+ LL  LL KDPK+RLG G + A+E+  H FF G+ 
Sbjct: 356 ---KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412

Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPP 345
           W  +  +K+  PF+PQ+ SE D   F EEFT      +PP
Sbjct: 413 WQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 452



 Score =  117 bits (293), Expect = 4e-26
 Identities = 83/253 (32%), Positives = 128/253 (50%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           LG+G+F      +++ +G+ +A+KIL + +       A+T  E   L+  + HP +  L 
Sbjct: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALK 214

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                      V+E   GGEL  H+ ++R FSE  A      +VSA+ ++H E  VV+RD
Sbjct: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK EN++   D     +KI DFG  +      G  M+T C T +Y APE+L    Y  + 
Sbjct: 275 LKLENLMLDKD---GHIKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LGV++Y M+ G++PF          +  E++  + E RF       + +  EAK L
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQD----HEKLFELIL-MEEIRFP------RTLGPEAKSL 379

Query: 645 VRGLLTVDPAKRL 657
           + GLL  DP +RL
Sbjct: 380 LSGLLKKDPKQRL 392


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  262 bits (670), Expect = 8e-70
 Identities = 144/340 (42%), Positives = 209/340 (61%), Gaps = 15/340 (4%)

Query: 7   DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
           D S A E+   E +L   + +V++  FE LK+LG G +GKV LV++      G+ YAMK+
Sbjct: 127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKI 180

Query: 67  LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
           L+K  +V + +   HT TE  VL+  R  PFL  L Y+FQT  +L  +++Y +GGE+F H
Sbjct: 181 LKKEVIVAKDEVA-HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFH 238

Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLH-KLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
           L + + F E   R YG EIV AL++LH +  ++YRDLKLEN++LD +GHI +TDFGL KE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298

Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
            + +      +FCGT EY+APE++     +G+AVDWW LG++++E++ G  PF  +    
Sbjct: 299 GIKDGATMK-TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE- 355

Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
              ++   IL     FP  +GP A+ LL  LL KDPK+RLG G + A+E+  H FF G+ 
Sbjct: 356 ---KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412

Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPP 345
           W  +  +K+  PF+PQ+ SE D   F EEFT      +PP
Sbjct: 413 WQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 452



 Score =  117 bits (293), Expect = 4e-26
 Identities = 83/253 (32%), Positives = 128/253 (50%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           LG+G+F      +++ +G+ +A+KIL + +       A+T  E   L+  + HP +  L 
Sbjct: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALK 214

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                      V+E   GGEL  H+ ++R FSE  A      +VSA+ ++H E  VV+RD
Sbjct: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK EN++   D     +KI DFG  +      G  M+T C T +Y APE+L    Y  + 
Sbjct: 275 LKLENLMLDKD---GHIKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LGV++Y M+ G++PF          +  E++  + E RF       + +  EAK L
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQD----HEKLFELIL-MEEIRFP------RTLGPEAKSL 379

Query: 645 VRGLLTVDPAKRL 657
           + GLL  DP +RL
Sbjct: 380 LSGLLKKDPKQRL 392


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  262 bits (670), Expect = 8e-70
 Identities = 144/340 (42%), Positives = 209/340 (61%), Gaps = 15/340 (4%)

Query: 7   DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
           D S A E+   E +L   + +V++  FE LK+LG G +GKV LV++      G+ YAMK+
Sbjct: 127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKI 180

Query: 67  LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
           L+K  +V + +   HT TE  VL+  R  PFL  L Y+FQT  +L  +++Y +GGE+F H
Sbjct: 181 LKKEVIVAKDEVA-HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFH 238

Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLH-KLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
           L + + F E   R YG EIV AL++LH +  ++YRDLKLEN++LD +GHI +TDFGL KE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298

Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
            + +      +FCGT EY+APE++     +G+AVDWW LG++++E++ G  PF  +    
Sbjct: 299 GIKDGATMK-TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE- 355

Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
              ++   IL     FP  +GP A+ LL  LL KDPK+RLG G + A+E+  H FF G+ 
Sbjct: 356 ---KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412

Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPP 345
           W  +  +K+  PF+PQ+ SE D   F EEFT      +PP
Sbjct: 413 WQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 452



 Score =  117 bits (293), Expect = 4e-26
 Identities = 83/253 (32%), Positives = 128/253 (50%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           LG+G+F      +++ +G+ +A+KIL + +       A+T  E   L+  + HP +  L 
Sbjct: 156 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALK 214

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                      V+E   GGEL  H+ ++R FSE  A      +VSA+ ++H E  VV+RD
Sbjct: 215 YSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRD 274

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK EN++   D     +KI DFG  +      G  M+T C T +Y APE+L    Y  + 
Sbjct: 275 LKLENLMLDKD---GHIKITDFGLCK-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LGV++Y M+ G++PF          +  E++  + E RF       + +  EAK L
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQD----HEKLFELIL-MEEIRFP------RTLGPEAKSL 379

Query: 645 VRGLLTVDPAKRL 657
           + GLL  DP +RL
Sbjct: 380 LSGLLKKDPKQRL 392


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  261 bits (666), Expect = 2e-69
 Identities = 142/349 (40%), Positives = 217/349 (62%), Gaps = 16/349 (4%)

Query: 28  VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
           + +++F+LL+V+G G+Y KV LVR        ++YAMKV++K  LV   +  +  +TE+ 
Sbjct: 249 LGLQDFDLLRVIGRGSYAKVLLVRLK---KTDRIYAMKVVKKE-LVNDDEDIDWVQTEKH 304

Query: 88  VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVL 147
           V E     PFLV LH  FQT+++L  +++YV+GG++  H+ +++   E   R Y  EI L
Sbjct: 305 VFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL 364

Query: 148 ALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207
           AL +LH+ GIIYRDLKL+NVLLDSEGHI LTD+G+ KE L    + T +FCGT  Y+APE
Sbjct: 365 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGL-RPGDTTSTFCGTPNYIAPE 423

Query: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEG-----ERNTQAEVSRRILKCSPPFP 262
           I+R +  +G +VDWW+LG+L+FE++ G SPF + G     ++NT+  + + IL+     P
Sbjct: 424 ILRGE-DYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482

Query: 263 PRIGPVAQDLLQRLLCKDPKKRLGAGPQ-GAQEVRNHPFFQGLDWVALAARKIPAPFRPQ 321
             +   A  +L+  L KDPK+RLG  PQ G  +++ HPFF+ +DW  +  +++  PF+P 
Sbjct: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542

Query: 322 IRSELDVGNFAEEFTRLEPVYSPPGSPP---PGDPRIFQGYSFVAPSIL 367
           I  E  + NF  +FT  EPV   P         D   F+G+ ++ P ++
Sbjct: 543 ISGEFGLDNFDSQFTN-EPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM 590



 Score =  110 bits (276), Expect = 4e-24
 Identities = 71/255 (27%), Positives = 133/255 (52%), Gaps = 17/255 (6%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 464
           +G+GS++     R +++ + +A+K++ + L  +       Q E        +HP +V LH
Sbjct: 260 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLH 319

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                +   + V+E + GG+L+ H++++R   E  A      +  A++++HE  G+++RD
Sbjct: 320 SCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER-GIIYRD 378

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK +N+L   D+ G  +K+ D+G  +     PG    T C T  Y APE+L  + Y  S 
Sbjct: 379 LKLDNVLL--DSEGH-IKLTDYGMCK-EGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV 434

Query: 585 DLWSLGVILYMMLSGQVPFQ--GASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAK 642
           D W+LGV+++ M++G+ PF   G+S    Q+    +   I E +  +     + +S +A 
Sbjct: 435 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP----RSLSVKAA 490

Query: 643 ELVRGLLTVDPAKRL 657
            +++  L  DP +RL
Sbjct: 491 SVLKSFLNKDPKERL 505


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  258 bits (658), Expect = 2e-68
 Identities = 142/343 (41%), Positives = 209/343 (60%), Gaps = 13/343 (3%)

Query: 27  KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
           ++ ++NFE ++VLG G++GKV L R     + G LYA+KVL+K  ++Q     E T TE+
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVK---ETGDLYAVKVLKKDVILQDDDV-ECTMTEK 404

Query: 87  SVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIV 146
            +L L R  PFL  L   FQT  +L  ++++V+GG++  H+ + + F EA  R Y  EI+
Sbjct: 405 RILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEII 464

Query: 147 LALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAP 206
            AL  LH  GIIYRDLKL+NVLLD EGH  L DFG+ KE +      T +FCGT +Y+AP
Sbjct: 465 SALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGIC-NGVTTATFCGTPDYIAP 523

Query: 207 EIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIG 266
           EI++    +G AVDWW++G+LL+E+L G +PF  E E     ++   IL     +P  + 
Sbjct: 524 EILQEML-YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLH 578

Query: 267 PVAQDLLQRLLCKDPKKRLGAGPQGAQE-VRNHPFFQGLDWVALAARKIPAPFRPQIRSE 325
             A  +L+  + K+P  RLG+  QG +  +  HPFF+ +DW  L  R+I  PFRP+I+S 
Sbjct: 579 EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSR 638

Query: 326 LDVGNFAEEFTRLEPVYSP--PGSPPPGDPRIFQGYSFVAPSI 366
            DV NF  +F + EPV +P   G  P  +   F+ +S+V+P +
Sbjct: 639 EDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681



 Score =  113 bits (283), Expect = 6e-25
 Identities = 67/200 (33%), Positives = 106/200 (53%), Gaps = 11/200 (5%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 464
           LG+GSF      R +++G  +AVK+L + +         T  E   L L ++HP +  L 
Sbjct: 361 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 420

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    + V+E + GG+L+ HI+K R F E+ A      ++SA+ F+H++ G+++RD
Sbjct: 421 CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDK-GIIYRD 479

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK +N+L   +      K+ DFG  +      GV   T C T  Y APE+L +  Y  + 
Sbjct: 480 LKLDNVLLDHE---GHCKLADFGMCK-EGICNGVTTATFCGTPDYIAPEILQEMLYGPAV 535

Query: 585 DLWSLGVILYMMLSGQVPFQ 604
           D W++GV+LY ML G  PF+
Sbjct: 536 DWWAMGVLLYEMLCGHAPFE 555


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  258 bits (658), Expect = 2e-68
 Identities = 149/343 (43%), Positives = 201/343 (58%), Gaps = 14/343 (4%)

Query: 4   EDDDESCAVELRITEANLT---GHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
           ED+DE  + +L  T  N+             +F+ LKV+G G++GKV L ++      GK
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GK 186

Query: 61  LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
            YA+KVL+K  ++ R K Q+H   ER+VL    + PFLV LHY+FQT  KL+ +LD+V+G
Sbjct: 187 FYAVKVLQKKIVLNR-KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNG 245

Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
           GE+F HL + + F E   R Y  EI  AL +LH + I+YRDLK EN+LLDS GH+VLTDF
Sbjct: 246 GELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDF 305

Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
           GL KE +    + T +FCGT EY+APE+IR K  +   VDWW LG +L+E+L G  PF  
Sbjct: 306 GLCKEGIA-ISDTTTTFCGTPEYLAPEVIR-KQPYDNTVDWWCLGAVLYEMLYGLPPFYC 363

Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
                  AE+   IL       P +   A  +L+ LL KD + RLGA  +   E++NHPF
Sbjct: 364 ----RDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPF 418

Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYS 343
           F+ L W  L  +KIP PF P +    D+ NF   FT     YS
Sbjct: 419 FESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYS 461



 Score =  108 bits (271), Expect = 1e-23
 Identities = 71/203 (34%), Positives = 108/203 (53%), Gaps = 19/203 (9%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANT--QREVAALRLCQ----SHPNVVNLH 464
           +G+GSF      +++  G+ +AVK+L +++  N   Q+ + A R        HP +V LH
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y VL+ + GGEL  H++++R F E  A      + SA+ ++H    +V+RD
Sbjct: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHS-IKIVYRD 286

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQ----TPCFTLQYAAPELLAQQGY 580
           LKPENIL   D+ G  V + DFG  +      G+ +     T C T +Y APE++ +Q Y
Sbjct: 287 LKPENILL--DSVGHVV-LTDFGLCK-----EGIAISDTTTTFCGTPEYLAPEVIRKQPY 338

Query: 581 DESCDLWSLGVILYMMLSGQVPF 603
           D + D W LG +LY ML G  PF
Sbjct: 339 DNTVDWWCLGAVLYEMLYGLPPF 361


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  258 bits (658), Expect = 2e-68
 Identities = 149/343 (43%), Positives = 201/343 (58%), Gaps = 14/343 (4%)

Query: 4   EDDDESCAVELRITEANLT---GHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
           ED+DE  + +L  T  N+             +F+ LKV+G G++GKV L ++      GK
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GK 186

Query: 61  LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
            YA+KVL+K  ++ R K Q+H   ER+VL    + PFLV LHY+FQT  KL+ +LD+V+G
Sbjct: 187 FYAVKVLQKKIVLNR-KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNG 245

Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
           GE+F HL + + F E   R Y  EI  AL +LH + I+YRDLK EN+LLDS GH+VLTDF
Sbjct: 246 GELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDF 305

Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
           GL KE +    + T +FCGT EY+APE+IR K  +   VDWW LG +L+E+L G  PF  
Sbjct: 306 GLCKEGIA-ISDTTTTFCGTPEYLAPEVIR-KQPYDNTVDWWCLGAVLYEMLYGLPPFYC 363

Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
                  AE+   IL       P +   A  +L+ LL KD + RLGA  +   E++NHPF
Sbjct: 364 ----RDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPF 418

Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYS 343
           F+ L W  L  +KIP PF P +    D+ NF   FT     YS
Sbjct: 419 FESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYS 461



 Score =  108 bits (271), Expect = 1e-23
 Identities = 71/203 (34%), Positives = 108/203 (53%), Gaps = 19/203 (9%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANT--QREVAALRLCQ----SHPNVVNLH 464
           +G+GSF      +++  G+ +AVK+L +++  N   Q+ + A R        HP +V LH
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y VL+ + GGEL  H++++R F E  A      + SA+ ++H    +V+RD
Sbjct: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHS-IKIVYRD 286

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQ----TPCFTLQYAAPELLAQQGY 580
           LKPENIL   D+ G  V + DFG  +      G+ +     T C T +Y APE++ +Q Y
Sbjct: 287 LKPENILL--DSVGHVV-LTDFGLCK-----EGIAISDTTTTFCGTPEYLAPEVIRKQPY 338

Query: 581 DESCDLWSLGVILYMMLSGQVPF 603
           D + D W LG +LY ML G  PF
Sbjct: 339 DNTVDWWCLGAVLYEMLYGLPPF 361


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  257 bits (657), Expect = 2e-68
 Identities = 142/344 (41%), Positives = 212/344 (61%), Gaps = 13/344 (3%)

Query: 26  EKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTE 85
           ++V + +F  L VLG G++GKV L  + G  +   LYA+K+L+K  ++Q     E T  E
Sbjct: 332 DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE---LYAIKILKKDVVIQDDDV-ECTMVE 387

Query: 86  RSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEI 145
           + VL L+ + PFL  LH  FQT  +L+ +++YV+GG++  H+ Q   FKE +   Y  EI
Sbjct: 388 KRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEI 447

Query: 146 VLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMA 205
            + L  LHK GIIYRDLKL+NV+LDSEGHI + DFG+ KE +  +   T +FCGT +Y+A
Sbjct: 448 SIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM-DGVTTRTFCGTPDYIA 506

Query: 206 PEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI 265
           PEII  +  +GK+VDWW+ G+LL+E+L G  PF  E E     E+ + I++ +  +P  +
Sbjct: 507 PEIIAYQP-YGKSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSL 561

Query: 266 GPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSE 325
              A  + + L+ K P KRLG GP+G ++VR H FF+ +DW  L  R+I  PF+P++  +
Sbjct: 562 SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK 621

Query: 326 LDVGNFAEEFTRLEPVYSPPGSPPPG--DPRIFQGYSFVAPSIL 367
               NF + FTR +PV +PP        D   F+G+S+V P  +
Sbjct: 622 -GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFV 664



 Score =  120 bits (300), Expect = 6e-27
 Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 464
           LG+GSF       ++ + + +A+KIL + +         T  E   L L    P +  LH
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y V+E + GG+L+ HI++   F E +A      +   + F+H+  G+++RD
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR-GIIYRD 463

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK +N++   D+ G  +KI DFG  +      GV  +T C T  Y APE++A Q Y +S 
Sbjct: 464 LKLDNVML--DSEGH-IKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSV 519

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W+ GV+LY ML+GQ PF G           E+   I E   S      + +S+EA  +
Sbjct: 520 DWWAYGVLLYEMLAGQPPFDG-------EDEDELFQSIMEHNVSYP----KSLSKEAVSI 568

Query: 645 VRGLLTVDPAKRL 657
            +GL+T  PAKRL
Sbjct: 569 CKGLMTKHPAKRL 581


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  250 bits (638), Expect = 4e-66
 Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)

Query: 32  NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
           +F  LKV+G G++GKV L R    H A ++ YA+KVL+K A++++ K ++H  +ER+VL 
Sbjct: 97  DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 151

Query: 91  LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
              + PFLV LH++FQT  KL+ +LDY++GGE+F HL + + F E   R Y  EI  AL 
Sbjct: 152 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 211

Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
           +LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E    T +FCGT EY+APE++ 
Sbjct: 212 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 270

Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
            K  + + VDWW LG +L+E+L G  PF     RNT AE+   IL       P I   A+
Sbjct: 271 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 325

Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
            LL+ LL KD  KRLGA      E+++H FF  ++W  L  +KI  PF P +    D+ +
Sbjct: 326 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 384

Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
           F  EFT  EPV +  G  P               F G+S+  P+  F
Sbjct: 385 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 430



 Score =  110 bits (276), Expect = 4e-24
 Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           +G+GSF      R +     +AVK+L ++       E +   E   L     HP +V LH
Sbjct: 104 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 163

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y VL+ + GGEL  H++++R F E  A      + SA+ ++H    +V+RD
Sbjct: 164 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 222

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LKPENIL   D+ G  V + DFG  +   +       T C T +Y APE+L +Q YD + 
Sbjct: 223 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 278

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LG +LY ML G  PF   +        AE+   I      L       ++  A+ L
Sbjct: 279 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 327

Query: 645 VRGLLTVDPAKRL 657
           + GLL  D  KRL
Sbjct: 328 LEGLLQKDRTKRL 340


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  250 bits (638), Expect = 4e-66
 Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)

Query: 32  NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
           +F  LKV+G G++GKV L R    H A ++ YA+KVL+K A++++ K ++H  +ER+VL 
Sbjct: 111 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 165

Query: 91  LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
              + PFLV LH++FQT  KL+ +LDY++GGE+F HL + + F E   R Y  EI  AL 
Sbjct: 166 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 225

Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
           +LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E    T +FCGT EY+APE++ 
Sbjct: 226 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 284

Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
            K  + + VDWW LG +L+E+L G  PF     RNT AE+   IL       P I   A+
Sbjct: 285 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 339

Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
            LL+ LL KD  KRLGA      E+++H FF  ++W  L  +KI  PF P +    D+ +
Sbjct: 340 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 398

Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
           F  EFT  EPV +  G  P               F G+S+  P+  F
Sbjct: 399 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 444



 Score =  110 bits (276), Expect = 4e-24
 Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           +G+GSF      R +     +AVK+L ++       E +   E   L     HP +V LH
Sbjct: 118 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 177

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y VL+ + GGEL  H++++R F E  A      + SA+ ++H    +V+RD
Sbjct: 178 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 236

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LKPENIL   D+ G  V + DFG  +   +       T C T +Y APE+L +Q YD + 
Sbjct: 237 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 292

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LG +LY ML G  PF   +        AE+   I      L       ++  A+ L
Sbjct: 293 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 341

Query: 645 VRGLLTVDPAKRL 657
           + GLL  D  KRL
Sbjct: 342 LEGLLQKDRTKRL 354


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  250 bits (638), Expect = 4e-66
 Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)

Query: 32  NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
           +F  LKV+G G++GKV L R    H A ++ YA+KVL+K A++++ K ++H  +ER+VL 
Sbjct: 125 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 179

Query: 91  LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
              + PFLV LH++FQT  KL+ +LDY++GGE+F HL + + F E   R Y  EI  AL 
Sbjct: 180 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 239

Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
           +LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E    T +FCGT EY+APE++ 
Sbjct: 240 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 298

Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
            K  + + VDWW LG +L+E+L G  PF     RNT AE+   IL       P I   A+
Sbjct: 299 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 353

Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
            LL+ LL KD  KRLGA      E+++H FF  ++W  L  +KI  PF P +    D+ +
Sbjct: 354 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 412

Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
           F  EFT  EPV +  G  P               F G+S+  P+  F
Sbjct: 413 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 458



 Score =  110 bits (276), Expect = 4e-24
 Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           +G+GSF      R +     +AVK+L ++       E +   E   L     HP +V LH
Sbjct: 132 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 191

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y VL+ + GGEL  H++++R F E  A      + SA+ ++H    +V+RD
Sbjct: 192 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 250

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LKPENIL   D+ G  V + DFG  +   +       T C T +Y APE+L +Q YD + 
Sbjct: 251 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 306

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LG +LY ML G  PF   +        AE+   I      L       ++  A+ L
Sbjct: 307 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 355

Query: 645 VRGLLTVDPAKRL 657
           + GLL  D  KRL
Sbjct: 356 LEGLLQKDRTKRL 368


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  250 bits (638), Expect = 4e-66
 Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)

Query: 32  NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
           +F  LKV+G G++GKV L R    H A ++ YA+KVL+K A++++ K ++H  +ER+VL 
Sbjct: 192 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 246

Query: 91  LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
              + PFLV LH++FQT  KL+ +LDY++GGE+F HL + + F E   R Y  EI  AL 
Sbjct: 247 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 306

Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
           +LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E    T +FCGT EY+APE++ 
Sbjct: 307 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 365

Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
            K  + + VDWW LG +L+E+L G  PF     RNT AE+   IL       P I   A+
Sbjct: 366 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 420

Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
            LL+ LL KD  KRLGA      E+++H FF  ++W  L  +KI  PF P +    D+ +
Sbjct: 421 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 479

Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
           F  EFT  EPV +  G  P               F G+S+  P+  F
Sbjct: 480 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 525



 Score =  110 bits (276), Expect = 4e-24
 Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 464
           +G+GSF      R +     +AVK+L ++       E +   E   L     HP +V LH
Sbjct: 199 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 258

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y VL+ + GGEL  H++++R F E  A      + SA+ ++H    +V+RD
Sbjct: 259 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 317

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LKPENIL   D+ G  V + DFG  +   +       T C T +Y APE+L +Q YD + 
Sbjct: 318 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 373

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W LG +LY ML G  PF   +        AE+   I      L       ++  A+ L
Sbjct: 374 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 422

Query: 645 VRGLLTVDPAKRL 657
           + GLL  D  KRL
Sbjct: 423 LEGLLQKDRTKRL 435


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  249 bits (637), Expect = 5e-66
 Identities = 138/357 (38%), Positives = 216/357 (60%), Gaps = 14/357 (3%)

Query: 16  ITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQR 75
           +++ +  G+ +++ + +F  L VLG G++GKV L  + G     +LYA+K+L+K  ++Q 
Sbjct: 325 VSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG---TDELYAVKILKKDVVIQD 381

Query: 76  AKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKE 135
               E T  E+ VL L  + PFL  LH  FQT  +L+ +++YV+GG++  H+ Q   FKE
Sbjct: 382 DDV-ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 440

Query: 136 AEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTF 195
                Y  EI + L  L   GIIYRDLKL+NV+LDSEGHI + DFG+ KE +  +   T 
Sbjct: 441 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTK 499

Query: 196 SFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRIL 255
           +FCGT +Y+APEII  +  +GK+VDWW+ G+LL+E+L G +PF  EGE   + E+ + I+
Sbjct: 500 TFCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPF--EGE--DEDELFQSIM 554

Query: 256 KCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIP 315
           + +  +P  +   A  + + L+ K P KRLG GP+G ++++ H FF+ +DW  L  ++I 
Sbjct: 555 EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQ 614

Query: 316 APFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP---PPGDPRIFQGYSFVAPSILFD 369
            P++P+ R + D  NF +EFTR +PV   P         D   F G+S+  P  + +
Sbjct: 615 PPYKPKARDKRDTSNFDKEFTR-QPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVIN 670



 Score =  115 bits (287), Expect = 2e-25
 Identities = 81/253 (32%), Positives = 125/253 (49%), Gaps = 22/253 (8%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 464
           LG+GSF       ++ + + +AVKIL + +         T  E   L L    P +  LH
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    Y V+E + GG+L+ HI++   F E  A      +   + F+  + G+++RD
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK-GIIYRD 466

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK +N++   D+ G  +KI DFG  +      GV  +T C T  Y APE++A Q Y +S 
Sbjct: 467 LKLDNVML--DSEGH-IKIADFGMCKENIWD-GVTTKTFCGTPDYIAPEIIAYQPYGKSV 522

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W+ GV+LY ML+GQ PF+G           E+   I E   +      + +S+EA  +
Sbjct: 523 DWWAFGVLLYEMLAGQAPFEG-------EDEDELFQSIMEHNVAYP----KSMSKEAVAI 571

Query: 645 VRGLLTVDPAKRL 657
            +GL+T  P KRL
Sbjct: 572 CKGLMTKHPGKRL 584


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  248 bits (634), Expect = 1e-65
 Identities = 140/347 (40%), Positives = 214/347 (61%), Gaps = 14/347 (4%)

Query: 28  VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
           + +++F+L++V+G G+Y KV LVR        ++YAMKV++K  LV   +  +  +TE+ 
Sbjct: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKND---QIYAMKVVKKE-LVHDDEDIDWVQTEKH 119

Query: 88  VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVL 147
           V E     PFLV LH  FQT ++L L+++YV+GG++  H+ +++   E   R Y  EI +
Sbjct: 120 VFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICI 179

Query: 148 ALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207
           AL  LH+ GIIYRDLKL+NVLLD++GHI LTD+G+ KE L    + T +FCGT  Y+APE
Sbjct: 180 ALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGL-GPGDTTSTFCGTPNYIAPE 238

Query: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPF---TLEGERNTQAEVSRRILKCSPPFPPR 264
           I+R +  +G +VDWW+LG+L+FE++ G SPF   T   + NT+  + + IL+     P  
Sbjct: 239 ILRGEE-YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 297

Query: 265 IGPVAQDLLQRLLCKDPKKRLGAGPQ-GAQEVRNHPFFQGLDWVALAARKIPAPFRPQIR 323
           +   A  +L+  L KDPK+RLG  PQ G  ++++H FF+ +DW  L  ++   PF+PQI 
Sbjct: 298 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 357

Query: 324 SELDVGNFAEEFTRLEPVYSPPGSPPP---GDPRIFQGYSFVAPSIL 367
            +  + NF  +FT  EPV   P         D   F+G+ ++ P +L
Sbjct: 358 DDYGLDNFDTQFTS-EPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403



 Score =  111 bits (277), Expect = 3e-24
 Identities = 71/253 (28%), Positives = 128/253 (50%), Gaps = 15/253 (5%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 464
           +G+GS++     R +++ Q +A+K++ + L  +       Q E        S+P +V LH
Sbjct: 75  IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH 134

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    +LV+E + GG+L+ H++++R   E  A      +  A++F+HE  G+++RD
Sbjct: 135 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER-GIIYRD 193

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK +N+L   D     +K+ D+G  +     PG    T C T  Y APE+L  + Y  S 
Sbjct: 194 LKLDNVLLDAD---GHIKLTDYGMCK-EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 249

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W+LGV+++ M++G+ PF   +     +    +   I E    +     + +S +A  +
Sbjct: 250 DWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLSVKASHV 305

Query: 645 VRGLLTVDPAKRL 657
           ++G L  DP +RL
Sbjct: 306 LKGFLNKDPKERL 318


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  248 bits (634), Expect = 1e-65
 Identities = 140/347 (40%), Positives = 214/347 (61%), Gaps = 14/347 (4%)

Query: 28  VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
           + +++F+L++V+G G+Y KV LVR        ++YAMKV++K  LV   +  +  +TE+ 
Sbjct: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKND---QIYAMKVVKKE-LVHDDEDIDWVQTEKH 119

Query: 88  VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVL 147
           V E     PFLV LH  FQT ++L L+++YV+GG++  H+ +++   E   R Y  EI +
Sbjct: 120 VFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICI 179

Query: 148 ALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207
           AL  LH+ GIIYRDLKL+NVLLD++GHI LTD+G+ KE L    + T +FCGT  Y+APE
Sbjct: 180 ALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGL-GPGDTTSTFCGTPNYIAPE 238

Query: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPF---TLEGERNTQAEVSRRILKCSPPFPPR 264
           I+R +  +G +VDWW+LG+L+FE++ G SPF   T   + NT+  + + IL+     P  
Sbjct: 239 ILRGEE-YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 297

Query: 265 IGPVAQDLLQRLLCKDPKKRLGAGPQ-GAQEVRNHPFFQGLDWVALAARKIPAPFRPQIR 323
           +   A  +L+  L KDPK+RLG  PQ G  ++++H FF+ +DW  L  ++   PF+PQI 
Sbjct: 298 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 357

Query: 324 SELDVGNFAEEFTRLEPVYSPPGSPPP---GDPRIFQGYSFVAPSIL 367
            +  + NF  +FT  EPV   P         D   F+G+ ++ P +L
Sbjct: 358 DDYGLDNFDTQFTS-EPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403



 Score =  111 bits (277), Expect = 3e-24
 Identities = 71/253 (28%), Positives = 128/253 (50%), Gaps = 15/253 (5%)

Query: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 464
           +G+GS++     R +++ Q +A+K++ + L  +       Q E        S+P +V LH
Sbjct: 75  IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH 134

Query: 465 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 524
                    +LV+E + GG+L+ H++++R   E  A      +  A++F+HE  G+++RD
Sbjct: 135 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER-GIIYRD 193

Query: 525 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 584
           LK +N+L   D     +K+ D+G  +     PG    T C T  Y APE+L  + Y  S 
Sbjct: 194 LKLDNVLLDAD---GHIKLTDYGMCK-EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 249

Query: 585 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 644
           D W+LGV+++ M++G+ PF   +     +    +   I E    +     + +S +A  +
Sbjct: 250 DWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLSVKASHV 305

Query: 645 VRGLLTVDPAKRL 657
           ++G L  DP +RL
Sbjct: 306 LKGFLNKDPKERL 318


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,158,453
Number of Sequences: 37866
Number of extensions: 1623309
Number of successful extensions: 10770
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 5830
Number of HSP's gapped (non-prelim): 1992
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.