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Search of human proteins with 55743118
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743118 RAB3 GTPase-activating protein [Homo sapiens]
(981 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743118 RAB3 GTPase-activating protein [Homo sapiens] 1998 0.0
gi|223972612 Crm, cramped-like [Homo sapiens] 35 0.45
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 35 0.45
gi|56549640 septin 2 [Homo sapiens] 34 0.59
gi|56549638 septin 2 [Homo sapiens] 34 0.59
gi|56549636 septin 2 [Homo sapiens] 34 0.59
gi|4758158 septin 2 [Homo sapiens] 34 0.59
gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens] 33 1.0
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens] 33 1.7
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens] 33 1.7
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 32 2.9
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 32 2.9
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 32 2.9
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 32 2.9
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 32 2.9
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 32 2.9
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 32 2.9
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 32 2.9
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 32 2.9
gi|4759182 syntaxin 1A (brain) [Homo sapiens] 32 2.9
gi|145207958 transmembrane protein 16G isoform NGEP long [Homo s... 32 2.9
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 31 5.0
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 31 5.0
gi|21735548 centrosomal protein 2 [Homo sapiens] 31 5.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 31 5.0
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 31 5.0
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 31 5.0
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 31 5.0
gi|71061468 centromere protein E [Homo sapiens] 31 5.0
gi|16418379 syntaxin 1B [Homo sapiens] 31 6.5
>gi|55743118 RAB3 GTPase-activating protein [Homo sapiens]
Length = 981
Score = 1998 bits (5176), Expect = 0.0
Identities = 981/981 (100%), Positives = 981/981 (100%)
Query: 1 MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEE 60
MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEE
Sbjct: 1 MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEE 60
Query: 61 KSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQDLLGMNNDFPPRAHCLVR 120
KSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQDLLGMNNDFPPRAHCLVR
Sbjct: 61 KSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQDLLGMNNDFPPRAHCLVR 120
Query: 121 WYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGE 180
WYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGE
Sbjct: 121 WYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGE 180
Query: 181 CQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQ 240
CQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQ
Sbjct: 181 CQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQ 240
Query: 241 QYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYS 300
QYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYS
Sbjct: 241 QYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYS 300
Query: 301 DLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADI 360
DLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADI
Sbjct: 301 DLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADI 360
Query: 361 THALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVS 420
THALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVS
Sbjct: 361 THALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVS 420
Query: 421 EKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHL 480
EKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHL
Sbjct: 421 EKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHL 480
Query: 481 WQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASD 540
WQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASD
Sbjct: 481 WQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASD 540
Query: 541 VTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQ 600
VTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQ
Sbjct: 541 VTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQ 600
Query: 601 ESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAK 660
ESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAK
Sbjct: 601 ESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAK 660
Query: 661 LGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVV 720
LGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVV
Sbjct: 661 LGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVV 720
Query: 721 LKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHL 780
LKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHL
Sbjct: 721 LKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHL 780
Query: 781 LPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVE 840
LPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVE
Sbjct: 781 LPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVE 840
Query: 841 ALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVN 900
ALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVN
Sbjct: 841 ALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVN 900
Query: 901 AQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMY 960
AQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMY
Sbjct: 901 AQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMY 960
Query: 961 SVLTKEDFRLAGAFSSDTSFF 981
SVLTKEDFRLAGAFSSDTSFF
Sbjct: 961 SVLTKEDFRLAGAFSSDTSFF 981
>gi|223972612 Crm, cramped-like [Homo sapiens]
Length = 1269
Score = 34.7 bits (78), Expect = 0.45
Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 10/101 (9%)
Query: 532 EGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGE---VGKSWDSWS-DSEEEFFE 587
EG +S+ +V+ + P A G + NL + EK E V + W+SWS + + FFE
Sbjct: 118 EGGGSSSGNVSGVAPA-APAGGSRSSSRNLGSSGGEKEEGKKVRRQWESWSTEDKNTFFE 176
Query: 588 CL----SDTEELKGN-GQESGKKGGPKEMANLRPEGRLYQH 623
L D E ++ N + KKG P M + + R + +
Sbjct: 177 GLYEHGKDFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYY 217
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 34.7 bits (78), Expect = 0.45
Identities = 41/183 (22%), Positives = 74/183 (40%), Gaps = 30/183 (16%)
Query: 544 IYPGDAGKAGDQLVPDNLKETDKEKGEVG----KSWDSWSDSEEEFFE-----CLSDTEE 594
++P + G+ +P + DK G +G + D W + + + C + TEE
Sbjct: 346 VFPDEQLSDGENGIPVGVSP-DKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEE 404
Query: 595 LKGNGQESGKKGGPKEMANLRPEGRLYQHG-------KLTLLHNGEPLYIPVTQEPAPMT 647
+GQ +G P + +R + Q KL +H+ E L +T EP P T
Sbjct: 405 ENSHGQANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFE-LEKRLTLEPKPDT 463
Query: 648 EDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDY 707
+ LE E + K ++ + + L A + C+ P S D + W+ +Y
Sbjct: 464 DKFLETCLEKMQKDTSAGKESILPALLHKPCV-----------PAVSRTDHI-WHYDEEY 511
Query: 708 IEE 710
+ +
Sbjct: 512 LPD 514
>gi|56549640 septin 2 [Homo sapiens]
Length = 361
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/65 (29%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 779 HLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITN 838
+++P + A L +KE E L+ K+I+ +I H+ K+ H P+ E + E+ Q
Sbjct: 176 NIVPVIAKADTLTLKERERLK-----KRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRL 230
Query: 839 VEALI 843
++A I
Sbjct: 231 LKASI 235
>gi|56549638 septin 2 [Homo sapiens]
Length = 361
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/65 (29%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 779 HLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITN 838
+++P + A L +KE E L+ K+I+ +I H+ K+ H P+ E + E+ Q
Sbjct: 176 NIVPVIAKADTLTLKERERLK-----KRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRL 230
Query: 839 VEALI 843
++A I
Sbjct: 231 LKASI 235
>gi|56549636 septin 2 [Homo sapiens]
Length = 361
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/65 (29%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 779 HLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITN 838
+++P + A L +KE E L+ K+I+ +I H+ K+ H P+ E + E+ Q
Sbjct: 176 NIVPVIAKADTLTLKERERLK-----KRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRL 230
Query: 839 VEALI 843
++A I
Sbjct: 231 LKASI 235
>gi|4758158 septin 2 [Homo sapiens]
Length = 361
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/65 (29%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 779 HLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITN 838
+++P + A L +KE E L+ K+I+ +I H+ K+ H P+ E + E+ Q
Sbjct: 176 NIVPVIAKADTLTLKERERLK-----KRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRL 230
Query: 839 VEALI 843
++A I
Sbjct: 231 LKASI 235
>gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens]
Length = 251
Score = 33.5 bits (75), Expect = 1.0
Identities = 38/146 (26%), Positives = 61/146 (41%), Gaps = 13/146 (8%)
Query: 517 LQMLNCCIERKKARDEGK--KTSASDVTNIYPGDAGKAGDQL-VPDNLKETDKEKGEVGK 573
+Q +C + +K +G + A++ P AG GD+L PD+ K T++EKG + +
Sbjct: 88 VQASDCPLASEKGSGDGPWPEPEAAEGDEDKPTHAGGGGDELGKPDDDKPTEEEKGPLKR 147
Query: 574 S-WDSWSDSEEEFFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRLYQHGK--LTLLH 630
S D D+ + E D EE + ++ E A L +
Sbjct: 148 SAGDPPEDAPKRPKEAAPDQEE-----EAEAERAAEAERAAAAAAATAVDEESPFLVAVE 202
Query: 631 NGEPLYIP--VTQEPAPMTEDLLEEQ 654
NG P V + P P E+L EE+
Sbjct: 203 NGSAPSEPGLVCEPPQPEEEELREEE 228
>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
Length = 488
Score = 32.7 bits (73), Expect = 1.7
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 576 DSWSDSEEEFFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPL 635
D+ + +E+ +CL E+ K K K+ L+ RL + + +L E L
Sbjct: 145 DATQEYKEKLQKCLEPLEQ-KLQEITRCKSSEEKKPGELK---RLVESRRQQILREFEEL 200
Query: 636 YIPVTQEPAPMTEDLLEEQSEVLAKLGTSA--------EGAHLRARMQSACLLSDMESFK 687
+ + +E + L EE+ ++L +L +A + AHL A ++ CL S E K
Sbjct: 201 HRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLK 260
>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
Length = 518
Score = 32.7 bits (73), Expect = 1.7
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 576 DSWSDSEEEFFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPL 635
D+ + +E+ +CL E+ K K K+ L+ RL + + +L E L
Sbjct: 145 DATQEYKEKLQKCLEPLEQ-KLQEITRCKSSEEKKPGELK---RLVESRRQQILREFEEL 200
Query: 636 YIPVTQEPAPMTEDLLEEQSEVLAKLGTSA--------EGAHLRARMQSACLLSDMESFK 687
+ + +E + L EE+ ++L +L +A + AHL A ++ CL S E K
Sbjct: 201 HRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLK 260
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 32.0 bits (71), Expect = 2.9
Identities = 31/149 (20%), Positives = 62/149 (41%), Gaps = 6/149 (4%)
Query: 525 ERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEE 584
ERK+ R +GK + P A + +P LKE ++ G ++ E
Sbjct: 3 ERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSE 62
Query: 585 FFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRL-YQHGKLTLLHNGEPLYIPVTQ-- 641
+ S + NG E +K P+ + + G+ + K +L +GE + +++
Sbjct: 63 Y---SSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG 119
Query: 642 EPAPMTEDLLEEQSEVLAKLGTSAEGAHL 670
+ + E +E++ + S EGA++
Sbjct: 120 NDSASANITIVESNEIITGMPASTEGAYV 148
>gi|4759182 syntaxin 1A (brain) [Homo sapiens]
Length = 288
Score = 32.0 bits (71), Expect = 2.9
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 795 EESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFG 854
EE I + + ++++ S +L PNP++K EE+ +++++ + RS K K
Sbjct: 38 EEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRS-KLKSI 96
Query: 855 TEKCEQEE 862
+ EQEE
Sbjct: 97 EQSIEQEE 104
>gi|145207958 transmembrane protein 16G isoform NGEP long [Homo
sapiens]
Length = 933
Score = 32.0 bits (71), Expect = 2.9
Identities = 26/104 (25%), Positives = 47/104 (45%), Gaps = 2/104 (1%)
Query: 275 PISEL-HLATTWPH-LTEGIIVDNDVYSDLDPIQAPHWSVRVRKAENPQCLLGDFVTEFF 332
P+ EL + A+ W L + + N + + + ++S R R + P+ L D FF
Sbjct: 191 PLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFF 250
Query: 333 KICRRKESTDEILGRSAFEEEGKETADITHALSKLTEPASVPIH 376
+R + EIL ++ + E K I L++ A+ P+H
Sbjct: 251 TSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLH 294
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 31.2 bits (69), Expect = 5.0
Identities = 33/164 (20%), Positives = 67/164 (40%), Gaps = 9/164 (5%)
Query: 782 PCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNV-- 839
P + V++ + ++ LE + + +I++ + ++ P ++ EE + + V
Sbjct: 506 PQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLL 565
Query: 840 ---EALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRG----HAGR 892
+ R S +++ E E+E+E++D E C+ + E +GA G G
Sbjct: 566 GEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGA 625
Query: 893 IIHKLFVNAQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAG 936
KLF +AQ + + L P + + S P G
Sbjct: 626 GYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGG 669
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 31.2 bits (69), Expect = 5.0
Identities = 33/164 (20%), Positives = 67/164 (40%), Gaps = 9/164 (5%)
Query: 782 PCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNV-- 839
P + V++ + ++ LE + + +I++ + ++ P ++ EE + + V
Sbjct: 505 PQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLL 564
Query: 840 ---EALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRG----HAGR 892
+ R S +++ E E+E+E++D E C+ + E +GA G G
Sbjct: 565 GEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGA 624
Query: 893 IIHKLFVNAQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAG 936
KLF +AQ + + L P + + S P G
Sbjct: 625 GYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGG 668
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 31.2 bits (69), Expect = 5.0
Identities = 27/120 (22%), Positives = 56/120 (46%), Gaps = 3/120 (2%)
Query: 753 RLFDDTREAEKVLHYLAIQKPADLARHLLPCVIHAAVLKVKEE--ESLENISSVKKIIKQ 810
+L + + E+VL +K A + V AV + +++ E L+ +SS K++++
Sbjct: 712 QLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLES 771
Query: 811 IISHSSKVLHFPNPEDKKLEEIIHQITNVEALI-ARARSLKAKFGTEKCEQEEEKEDLER 869
+ + + +LE I +T + +I R LK + TE+ + E+E++ R
Sbjct: 772 SLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAAR 831
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 31.2 bits (69), Expect = 5.0
Identities = 58/289 (20%), Positives = 121/289 (41%), Gaps = 36/289 (12%)
Query: 594 ELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQ---EPAPMTEDL 650
EL+ + G++ K++ L+ + + +Q + + ++ + + + DL
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 651 LEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPR-DYIE 709
++ Q ++ A AE A +A ++ L ++ S + +L+D R R +E
Sbjct: 1690 MQLQEDLAA-----AERARKQADLEKEELAEELASSLSGRN--ALQDEKRRLEARIAQLE 1742
Query: 710 EEVIDEKGNVVLKGE----LSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVL 765
EE+ +E+GN+ + + + + SN TA+ + RQ+ L +E L
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ-LERQNKELRSKL 1801
Query: 766 HYLAIQKPADLARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPE 825
H + + + A L+ + E+ + K +KQ +
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ--------------K 1847
Query: 826 DKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQ-----EEEKEDLER 869
DKKL+EI+ Q+ + E +A +A+ G + +Q EE +E+ +R
Sbjct: 1848 DKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 31.2 bits (69), Expect = 5.0
Identities = 58/289 (20%), Positives = 121/289 (41%), Gaps = 36/289 (12%)
Query: 594 ELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQ---EPAPMTEDL 650
EL+ + G++ K++ L+ + + +Q + + ++ + + + DL
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 651 LEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPR-DYIE 709
++ Q ++ A AE A +A ++ L ++ S + +L+D R R +E
Sbjct: 1697 MQLQEDLAA-----AERARKQADLEKEELAEELASSLSGRN--ALQDEKRRLEARIAQLE 1749
Query: 710 EEVIDEKGNVVLKGE----LSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVL 765
EE+ +E+GN+ + + + + SN TA+ + RQ+ L +E L
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ-LERQNKELRSKL 1808
Query: 766 HYLAIQKPADLARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPE 825
H + + + A L+ + E+ + K +KQ +
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ--------------K 1854
Query: 826 DKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQ-----EEEKEDLER 869
DKKL+EI+ Q+ + E +A +A+ G + +Q EE +E+ +R
Sbjct: 1855 DKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 31.2 bits (69), Expect = 5.0
Identities = 58/289 (20%), Positives = 121/289 (41%), Gaps = 36/289 (12%)
Query: 594 ELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQ---EPAPMTEDL 650
EL+ + G++ K++ L+ + + +Q + + ++ + + + DL
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 651 LEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPR-DYIE 709
++ Q ++ A AE A +A ++ L ++ S + +L+D R R +E
Sbjct: 1697 MQLQEDLAA-----AERARKQADLEKEELAEELASSLSGRN--ALQDEKRRLEARIAQLE 1749
Query: 710 EEVIDEKGNVVLKGE----LSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVL 765
EE+ +E+GN+ + + + + SN TA+ + RQ+ L +E L
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ-LERQNKELRSKL 1808
Query: 766 HYLAIQKPADLARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPE 825
H + + + A L+ + E+ + K +KQ +
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ--------------K 1854
Query: 826 DKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQ-----EEEKEDLER 869
DKKL+EI+ Q+ + E +A +A+ G + +Q EE +E+ +R
Sbjct: 1855 DKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 31.2 bits (69), Expect = 5.0
Identities = 58/289 (20%), Positives = 121/289 (41%), Gaps = 36/289 (12%)
Query: 594 ELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQ---EPAPMTEDL 650
EL+ + G++ K++ L+ + + +Q + + ++ + + + DL
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 651 LEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPR-DYIE 709
++ Q ++ A AE A +A ++ L ++ S + +L+D R R +E
Sbjct: 1690 MQLQEDLAA-----AERARKQADLEKEELAEELASSLSGRN--ALQDEKRRLEARIAQLE 1742
Query: 710 EEVIDEKGNVVLKGE----LSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVL 765
EE+ +E+GN+ + + + + SN TA+ + RQ+ L +E L
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ-LERQNKELRSKL 1801
Query: 766 HYLAIQKPADLARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPE 825
H + + + A L+ + E+ + K +KQ +
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ--------------K 1847
Query: 826 DKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQ-----EEEKEDLER 869
DKKL+EI+ Q+ + E +A +A+ G + +Q EE +E+ +R
Sbjct: 1848 DKKLKEILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 31.2 bits (69), Expect = 5.0
Identities = 18/82 (21%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 789 VLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARS 848
V+ + E +SL S V+++ K+I S ++ + +DK E++H+ + V+ L+
Sbjct: 743 VILLSELKSLP--SEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 849 LKAKFGTEKCEQEEEKEDLERF 870
K T + + ++ + F
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNF 822
>gi|16418379 syntaxin 1B [Homo sapiens]
Length = 288
Score = 30.8 bits (68), Expect = 6.5
Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 1/68 (1%)
Query: 795 EESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFG 854
EE I + + ++Q+ S +L PNP++K +E+ +++ + RS K K
Sbjct: 37 EEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRS-KLKAI 95
Query: 855 TEKCEQEE 862
+ EQEE
Sbjct: 96 EQSIEQEE 103
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,346,231
Number of Sequences: 37866
Number of extensions: 2141946
Number of successful extensions: 6183
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 6150
Number of HSP's gapped (non-prelim): 79
length of query: 981
length of database: 18,247,518
effective HSP length: 112
effective length of query: 869
effective length of database: 14,006,526
effective search space: 12171671094
effective search space used: 12171671094
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.