Guide to the Human Genome
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Search of human proteins with 54792105

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
         (466 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]          944   0.0  
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]         944   0.0  
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]         523   e-148
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]          408   e-114
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]         391   e-109
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]          388   e-108
gi|149158709 histamine receptor H1 [Homo sapiens]                     189   5e-48
gi|149158706 histamine receptor H1 [Homo sapiens]                     189   5e-48
gi|149158704 histamine receptor H1 [Homo sapiens]                     189   5e-48
gi|4504491 histamine receptor H1 [Homo sapiens]                       189   5e-48
gi|194018562 histamine receptor H3 [Homo sapiens]                     186   3e-47
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   173   3e-43
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         150   3e-36
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]           149   5e-36
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]              149   7e-36
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]               137   2e-32
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]               136   5e-32
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    133   3e-31
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    133   3e-31
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    133   3e-31
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    133   3e-31
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   131   1e-30
gi|32483397 dopamine receptor D4 [Homo sapiens]                       127   2e-29
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   125   6e-29

>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  944 bits (2439), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
Sbjct: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
Sbjct: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
           FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
Sbjct: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240

Query: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300
           VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
Sbjct: 241 VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE 300

Query: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360
           ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
Sbjct: 301 ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI 360

Query: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420
           VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
Sbjct: 361 VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT 420

Query: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Sbjct: 421 VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466


>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
          Length = 479

 Score =  523 bits (1347), Expect = e-148
 Identities = 277/478 (57%), Positives = 344/478 (71%), Gaps = 25/478 (5%)

Query: 6   NSSNNSLALTSP-----YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           +S N S+ L +      Y+T E+VFI  V GSLSLVT++GNILVM+SIKVNR LQTVNNY
Sbjct: 10  SSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNY 69

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           FLFSLACADLIIG FSMNLYT+Y + GYWPLG VVCDLWLALDYVVSNASVMNLLIISFD
Sbjct: 70  FLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFD 129

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RYFCVTKPLTYP +RTTKMAG+MIAAAWVLSF+LWAPAILFWQF+VG RTV D +C+IQF
Sbjct: 130 RYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQF 189

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI 240
            SN AVTFGTAIAAFYLPV+IMTVLY HIS AS+SR+ K + E    +   + + ++  +
Sbjct: 190 LSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPL 249

Query: 241 VKPNNNNMPSSD---DGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMR 297
           +K +    P  +   + L + K++    P  P     V   +K++SN+S+S SA   N +
Sbjct: 250 MKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPV--ADKDTSNESSSGSA-TQNTK 306

Query: 298 DDEITQDENTVSTSLG--------HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGS 349
           +   T+   T +T+           + +  S+ + I+I TK   ++      T +E+V +
Sbjct: 307 ERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECV----TAIEIVPA 362

Query: 350 SGQNGDEKQNIVARKIVKMTK-QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVL 408
           +        N VARK   + + Q  KK+   +RE+KVTRTI AILLAFI+TW PYNVMVL
Sbjct: 363 TPAGMRPAAN-VARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVL 421

Query: 409 INTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 466
           +NTFC  CIP+TVW+IGYWLCY+NSTINPACYALCNATFKKTF+HLL+C Y+NIG  R
Sbjct: 422 VNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 479


>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
          Length = 590

 Score =  408 bits (1049), Expect = e-114
 Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)

Query: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
           +  ++VVFI  + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 63  HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122

Query: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
           NL+T Y ++  W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY  KRTT
Sbjct: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182

Query: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
           K AG+MI  AWV+SF+LWAPAILFWQ+ VG RTV  GEC+IQF S   +TFGTAIAAFY+
Sbjct: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242

Query: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
           PV IMT+LYW I + ++ R K              ++   P  +    S   +Q + +K 
Sbjct: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302

Query: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
           +N                 PSS+   + +   +     D     EN    +E++  +++ 
Sbjct: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362

Query: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
           ++ ++   +               D+    +E      L    D+   Q  +  G   PK
Sbjct: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422

Query: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
           S        +S   T  T +V  S G++        K+  +A++    T+    K+   S
Sbjct: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482

Query: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
             +EKK  +T+ AILLAFIITW PYN+MVL+NTFC  CIP T W +GYWLCYINST+NP 
Sbjct: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542

Query: 439 CYALCNATFKKTFKHLLMC 457
           CYALCN TF+ TFK LL+C
Sbjct: 543 CYALCNKTFRTTFKMLLLC 561


>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
          Length = 460

 Score =  391 bits (1004), Expect = e-109
 Identities = 209/452 (46%), Positives = 275/452 (60%), Gaps = 24/452 (5%)

Query: 8   SNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLAC 67
           S N   L      ++V FI +  G LSL T+ GN+LV++S KVN  L+TVNNYFL SLAC
Sbjct: 10  SPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLAC 69

Query: 68  ADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 127
           ADLIIG FSMNLYT Y ++G+W LG + CDLWLALDYV SNASVMNLL+ISFDRYF VT+
Sbjct: 70  ADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTR 129

Query: 128 PLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVT 187
           PL+Y  KRT + A +MI  AW++SF+LWAPAILFWQ++VG RTV  G+CYIQF S   +T
Sbjct: 130 PLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIIT 189

Query: 188 FGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNN 247
           FGTA+AAFYLPV +M  LYW I R +++R     +E  A Q   +P    G     +  +
Sbjct: 190 FGTAMAAFYLPVTVMCTLYWRIYRETENR----ARELAALQGSETPG-KGGGSSSSSERS 244

Query: 248 MPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENT 307
            P ++   E    +  +  R P        +E+E  ++ +  S  +S   + E    E  
Sbjct: 245 QPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSS---EGEEPGSEVV 301

Query: 308 VSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVK 367
           +   +   + +   +   R    T K     PT    +  G  GQ    K+ +  RK   
Sbjct: 302 IKMPMVDPEAQAPTKQPPRSSPNTVK----RPTKKGRDRAG-KGQKPRGKEQLAKRKTFS 356

Query: 368 MTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYW 427
           + K           EKK  RT+ AILLAFI+TW PYN+MVL++TFC  C+P T+W +GYW
Sbjct: 357 LVK-----------EKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYW 405

Query: 428 LCYINSTINPACYALCNATFKKTFKHLLMCHY 459
           LCY+NSTINP CYALCN  F+ TF+ LL+C +
Sbjct: 406 LCYVNSTINPMCYALCNKAFRDTFRLLLLCRW 437


>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
          Length = 532

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84

Query: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144

Query: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204

Query: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264

Query: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274
                         +    PS   G   N                    K   DPV +  
Sbjct: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324

Query: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373

Query: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432

Query: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492

Query: 438 ACYALCNATFKKTFKHLLMCHYK 460
            CYALCN TF+KTFK LL+C +K
Sbjct: 493 ICYALCNRTFRKTFKMLLLCRWK 515


>gi|149158709 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73

Query: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133

Query: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192

Query: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252

Query: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312

Query: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369

Query: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428

Query: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483


>gi|149158706 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73

Query: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133

Query: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192

Query: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252

Query: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312

Query: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369

Query: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428

Query: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483


>gi|149158704 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73

Query: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133

Query: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192

Query: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252

Query: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312

Query: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369

Query: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428

Query: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483


>gi|4504491 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73

Query: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133

Query: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192

Query: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252

Query: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312

Query: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369

Query: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428

Query: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483


>gi|194018562 histamine receptor H3 [Homo sapiens]
          Length = 445

 Score =  186 bits (473), Expect = 3e-47
 Identities = 124/469 (26%), Positives = 221/469 (47%), Gaps = 68/469 (14%)

Query: 3   NSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLV---TIIGNILVMVSIKVNRHLQTVNN 59
           N++ +     A     + F   +  ++A  ++L+   T++GN LVM++   +  L+T NN
Sbjct: 11  NASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70

Query: 60  YFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 119
           +FL +LA +D ++G F + LY  Y + G W  G  +C LWL +DY++  +S  N+++IS+
Sbjct: 71  FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130

Query: 120 DRYFCVTKPLTYPVKR-TTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYI 178
           DR+  VT+ ++Y  ++  T+ A   +   WVL+F+L+ PAIL W+++ G  ++ +G CY 
Sbjct: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190

Query: 179 QFFSNAAVTFGTAIAAFYLPVIIMTV----LYWHISRASKSRIKKDKK------EPVANQ 228
           +FF N       +   F+ P + +T     +Y +I R ++ R+   ++       P A  
Sbjct: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQP 250

Query: 229 DPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESS-NDST 287
            P  P    G   K +   MP    G               V E  V  E  E++     
Sbjct: 251 SPPPPPGCWGCWQKGHGEAMPLHRYG---------------VGEAAVGAEAGEATLGGGG 295

Query: 288 SVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVV 347
              +VAS              ++S G S     +   ++ G+K P + S +         
Sbjct: 296 GGGSVAS-------------PTSSSGSSSRGTERPRSLKRGSK-PSASSAS--------- 332

Query: 348 GSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMV 407
                           K +KM  Q   ++   SR++KV +++  I+  F + WAPY +++
Sbjct: 333 --------------LEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLM 378

Query: 408 LINTFC-APCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
           +I   C   C+P+  +   +WL + NS +NP  Y LC+ +F++ F  LL
Sbjct: 379 IIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLL 427


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  173 bits (439), Expect = 3e-43
 Identities = 130/470 (27%), Positives = 220/470 (46%), Gaps = 72/470 (15%)

Query: 2   NNSTN------SSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQ 55
           NN+T+      +  N+  ++    +++V+  +L+ G+L    ++GN  V+ +I + R LQ
Sbjct: 10  NNTTSPPAPFETGGNTTGISDVTVSYQVITSLLL-GTLIFCAVLGNACVVAAIALERSLQ 68

Query: 56  TVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLL 115
            V NY + SLA  DL++ V  + +  LY V+  W LG V CDL++ALD +   +S+++L 
Sbjct: 69  NVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLC 128

Query: 116 IISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVED-- 173
            I+ DRY+ +T P+ Y  KRT + A  +I+  W++ F++  P +L W      RT ED  
Sbjct: 129 AIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGW------RTPEDRS 182

Query: 174 --GECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPV 231
               C I    +   T  +   AFY+P+++M VLY  I RA++ RI+K  K         
Sbjct: 183 DPDACTIS--KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVK--------- 231

Query: 232 SPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSA 291
                  ++ K   +    +    +  K  NG++     + N   G E ++     +  A
Sbjct: 232 -------KVEKTGADTRHGASPAPQPKKSVNGESG----SRNWRLGVESKAGGALCANGA 280

Query: 292 VASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSG 351
           V     DD    +   V   +G+SK+              P      PT        +S 
Sbjct: 281 VRQG--DDGAALEVIEVH-RVGNSKEH------------LPLPSEAGPT----PCAPASF 321

Query: 352 QNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINT 411
           +  +E+               AK+K   +RE+K  +T+  I+  FI+ W P+ ++ L+  
Sbjct: 322 ERKNER------------NAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLP 369

Query: 412 FC-APC-IPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHY 459
           FC + C +P  +  I  WL Y NS +NP  YA  N  F+  FK ++ C +
Sbjct: 370 FCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF 419


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  150 bits (378), Expect = 3e-36
 Identities = 112/444 (25%), Positives = 186/444 (41%), Gaps = 67/444 (15%)

Query: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
           Y  +  +  +L+A     V + GN+LV +++   + LQT  NY + SLA ADL++    M
Sbjct: 34  YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88

Query: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
                  V+G W    + CD+++ LD ++  AS++NL  IS DRY  V  P+ Y  + ++
Sbjct: 89  PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148

Query: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
           K    +MI+  WVLSF +  P       + G+   +  EC I   +N A    ++I +FY
Sbjct: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199

Query: 197 LPVIIMTVLY---WHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
           +P I+  ++Y   + + R  + R+   +          +P     R  +     M SS  
Sbjct: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTS 259

Query: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
             E  +     +P  P        +       ST          D     ++N      G
Sbjct: 260 PPERTRY----SPIPPSHHQLTLPDPSHHGLHSTP---------DSPAKPEKN------G 300

Query: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
           H+KD         I T                       NG  + ++         K  +
Sbjct: 301 HAKDHPKIAKIFEIQTM---------------------PNGKTRTSL---------KTMS 330

Query: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINS 433
           ++K    +EKK T+ +  +L  FII W P+ +  ++N  C   IP  +++   WL Y+NS
Sbjct: 331 RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS 390

Query: 434 TINPACYALCNATFKKTFKHLLMC 457
            +NP  Y   N  F+K F  +L C
Sbjct: 391 AVNPIIYTTFNIEFRKAFLKILHC 414


>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
          Length = 443

 Score =  149 bits (376), Expect = 5e-36
 Identities = 113/452 (25%), Positives = 193/452 (42%), Gaps = 54/452 (11%)

Query: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
           Y  +  +  +L+A     V + GN+LV +++   + LQT  NY + SLA ADL++    M
Sbjct: 34  YNYYATLLTLLIA-----VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVM 88

Query: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
                  V+G W    + CD+++ LD ++  AS++NL  IS DRY  V  P+ Y  + ++
Sbjct: 89  PWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSS 148

Query: 138 K-MAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
           K    +MI+  WVLSF +  P       + G+   +  EC I   +N A    ++I +FY
Sbjct: 149 KRRVTVMISIVWVLSFTISCP------LLFGLNNADQNECII---ANPAFVVYSSIVSFY 199

Query: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLE 256
           +P I+  ++Y  I    + R K+   +        S    +  +  P   N    +D   
Sbjct: 200 VPFIVTLLVYIKIYIVLRRRRKRVNTKR-------SSRAFRAHLRAPLKGNCTHPEDMKL 252

Query: 257 HNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 316
              I        PV    V+   +    +   +S+          +  E T  + +  S 
Sbjct: 253 CTVIMKSNG-SFPVNRRRVEAARRAQELEMEMLSST---------SPPERTRYSPIPPSH 302

Query: 317 DENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQP---- 372
            +            T    S    ++T +      +NG  K +    KI ++   P    
Sbjct: 303 HQ-----------LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKT 351

Query: 373 -------AKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG 425
                  +++K    +EKK T+ +  +L  FII W P+ +  ++N  C   IP  +++  
Sbjct: 352 RTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAF 411

Query: 426 YWLCYINSTINPACYALCNATFKKTFKHLLMC 457
            WL Y+NS +NP  Y   N  F+K F  +L C
Sbjct: 412 TWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC 443


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score =  149 bits (375), Expect = 7e-36
 Identities = 105/445 (23%), Positives = 199/445 (44%), Gaps = 28/445 (6%)

Query: 13  ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
           A  +PY     + +V +AG L L+T+ GN+LV++++  +R L+   N FL SLA AD+++
Sbjct: 38  ARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILV 97

Query: 73  GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
               +       V+GYW  G   C+++LALD +   +S+++L  IS DRY+ +T+ + Y 
Sbjct: 98  ATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN 157

Query: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
           +KRT +    +I   WV+S ++  P ++  +   G    +  E   +          + I
Sbjct: 158 LKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCI 217

Query: 193 AAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSD 252
            +F+ P +IM ++Y  I + +K R +     P + + P + +   G   +  N   P   
Sbjct: 218 GSFFAPCLIMILVYVRIYQIAKRRTRV----PPSRRGPDAVAAPPGGTERRPNGLGPERS 273

Query: 253 DGLEHNKIQNGKAPRDPVTE--NCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVST 310
            G        G A  +P+    N   GE   +    T    +  +   D   +       
Sbjct: 274 AG-------PGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRP 326

Query: 311 SLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTK 370
             G      ++ + ++ G   P+     P  T +    +    G  ++ + A K      
Sbjct: 327 ERGPRGKGKARASQVKPGDSLPRRG---PGATGIGTPAA----GPGEERVGAAKA----- 374

Query: 371 QPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCY 430
             ++ +   +REK+ T  +  ++  F++ W P+     + T     +P T++   +W  Y
Sbjct: 375 --SRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTL-TAVGCSVPRTLFKFFFWFGY 431

Query: 431 INSTINPACYALCNATFKKTFKHLL 455
            NS++NP  Y + N  F++ FK +L
Sbjct: 432 CNSSLNPVIYTIFNHDFRRAFKKIL 456


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score =  137 bits (345), Expect = 2e-32
 Identities = 106/444 (23%), Positives = 195/444 (43%), Gaps = 43/444 (9%)

Query: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
           Y    V  +  V G L + T++GN+LV++++  +R L+   N FL SLA AD+++    M
Sbjct: 46  YSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVM 105

Query: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
                  ++ YW  G V C ++LALD +   +S+++L  IS DRY+ VT+ + Y +KRT 
Sbjct: 106 PFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTP 165

Query: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTF--GTAIAAF 195
           +     I A W++S ++  P       +V +    DG  Y Q   N    +   + I +F
Sbjct: 166 RRVKATIVAVWLISAVISFPP------LVSLYRQPDGAAYPQCGLNDETWYILSSCIGSF 219

Query: 196 YLPVIIMTVLYWHISRASKSRIK--KDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDD 253
           + P +IM ++Y  I R +K R +   +K+ PV   D  SP+   G               
Sbjct: 220 FAPCLIMGLVYARIYRVAKLRTRTLSEKRAPV-GPDGASPTTENGL-------------- 264

Query: 254 GLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLG 313
           G      +NG     P     V+ +E  ++ +       A           E     + G
Sbjct: 265 GAAAGAGENGHCAPPPAD---VEPDESSAAAERRRRRG-ALRRGGRRRAGAEGGAGGADG 320

Query: 314 HSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPA 373
                 + ++     +++P         ++  V     +    + ++  RK+ +     A
Sbjct: 321 QGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQ-----A 375

Query: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFC--APCIPNTVWTIGYWLCYI 431
           ++K       + T  +  ++  F++ W P+     +   C  A  +P  ++   +W+ Y 
Sbjct: 376 REK-------RFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYC 428

Query: 432 NSTINPACYALCNATFKKTFKHLL 455
           NS++NP  Y + N  F+++FKH+L
Sbjct: 429 NSSLNPVIYTVFNQDFRRSFKHIL 452


>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
          Length = 450

 Score =  136 bits (342), Expect = 5e-32
 Identities = 103/454 (22%), Positives = 201/454 (44%), Gaps = 33/454 (7%)

Query: 17  PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFS 76
           PY       I      L L TI GN LV++++  +R L+   N FL SLA AD+++    
Sbjct: 6   PYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLI 65

Query: 77  MNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 136
           +       ++GYW      C+++LALD +   +S+++L  IS DRY+ V++ L Y  KRT
Sbjct: 66  IPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 125

Query: 137 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFY 196
            +    +I   W+++ ++  P +++ +   G +     +C +     A     ++I +F+
Sbjct: 126 PRRIKCIILTVWLIAAVISLPPLIY-KGDQGPQPRGRPQCKLN--QEAWYILASSIGSFF 182

Query: 197 LPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGR---------IVKPNNNN 247
            P +IM ++Y  I   +K   + +++ P A   P      Q R            P   +
Sbjct: 183 APCLIMILVYLRIYLIAK---RSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALAS 239

Query: 248 MPSSDDGLEHNKI----QNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQ 303
           + S+ +   H+K     + G+ P D  T           ++       V     +DE  +
Sbjct: 240 VASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEE 299

Query: 304 DENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVAR 363
           +E          ++E  ++ C         + +C+P     +  GS        Q ++ R
Sbjct: 300 EE----------EEEEEEEECEPQAVPVSPASACSP--PLQQPQGSRVLATLRGQVLLGR 347

Query: 364 KIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-C-IPNTV 421
            +  +  Q  +++   +REK+ T  +  ++  F++ W P+     +   C   C +P+ +
Sbjct: 348 GVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGL 407

Query: 422 WTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455
           +   +W+ Y NS++NP  Y + N  F++ F+ +L
Sbjct: 408 FQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  133 bits (335), Expect = 3e-31
 Identities = 70/230 (30%), Positives = 121/230 (52%), Gaps = 12/230 (5%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           ++ + + S+N     +P    + + + ++ G L L  ++GNILV++S+  +RHL +V +Y
Sbjct: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           ++ +LA ADL++    +    ++ V+GYW  G V C++W A+D +   AS+M L IIS D
Sbjct: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RY  V+ PL YP   T +   M +   W LS ++    +  W+     +   + E   Q 
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQI 178

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHI-------SRASKSRIKKDKKE 223
                    +A+ +FYLP+ I+ V+Y  +       SR  KS +K DK +
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSD 228



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 9/132 (6%)

Query: 325 IRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKK 384
           ++ G KT KSDS   T         +G +G           V++ K         SREKK
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF--------SREKK 269

Query: 385 VTRTILAILLAFIITWAPYNVMVLINTFCAPCIPN-TVWTIGYWLCYINSTINPACYALC 443
             +T+  ++  F++ W P+ +++ I +F     P+ TV+ I +WL Y+NS INP  Y   
Sbjct: 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCS 329

Query: 444 NATFKKTFKHLL 455
           +  FKK F+++L
Sbjct: 330 SQEFKKAFQNVL 341


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  133 bits (335), Expect = 3e-31
 Identities = 70/230 (30%), Positives = 121/230 (52%), Gaps = 12/230 (5%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           ++ + + S+N     +P    + + + ++ G L L  ++GNILV++S+  +RHL +V +Y
Sbjct: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           ++ +LA ADL++    +    ++ V+GYW  G V C++W A+D +   AS+M L IIS D
Sbjct: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RY  V+ PL YP   T +   M +   W LS ++    +  W+     +   + E   Q 
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQI 178

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHI-------SRASKSRIKKDKKE 223
                    +A+ +FYLP+ I+ V+Y  +       SR  KS +K DK +
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSD 228



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 9/132 (6%)

Query: 325 IRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKK 384
           ++ G KT KSDS   T         +G +G           V++ K         SREKK
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF--------SREKK 269

Query: 385 VTRTILAILLAFIITWAPYNVMVLINTFCAPCIPN-TVWTIGYWLCYINSTINPACYALC 443
             +T+  ++  F++ W P+ +++ I +F     P+ TV+ I +WL Y+NS INP  Y   
Sbjct: 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCS 329

Query: 444 NATFKKTFKHLL 455
           +  FKK F+++L
Sbjct: 330 SQEFKKAFQNVL 341


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  133 bits (335), Expect = 3e-31
 Identities = 70/230 (30%), Positives = 121/230 (52%), Gaps = 12/230 (5%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           ++ + + S+N     +P    + + + ++ G L L  ++GNILV++S+  +RHL +V +Y
Sbjct: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           ++ +LA ADL++    +    ++ V+GYW  G V C++W A+D +   AS+M L IIS D
Sbjct: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RY  V+ PL YP   T +   M +   W LS ++    +  W+     +   + E   Q 
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQI 178

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHI-------SRASKSRIKKDKKE 223
                    +A+ +FYLP+ I+ V+Y  +       SR  KS +K DK +
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSD 228



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 9/132 (6%)

Query: 325 IRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKK 384
           ++ G KT KSDS   T         +G +G           V++ K         SREKK
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF--------SREKK 269

Query: 385 VTRTILAILLAFIITWAPYNVMVLINTFCAPCIPN-TVWTIGYWLCYINSTINPACYALC 443
             +T+  ++  F++ W P+ +++ I +F     P+ TV+ I +WL Y+NS INP  Y   
Sbjct: 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCS 329

Query: 444 NATFKKTFKHLL 455
           +  FKK F+++L
Sbjct: 330 SQEFKKAFQNVL 341


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  133 bits (335), Expect = 3e-31
 Identities = 70/230 (30%), Positives = 121/230 (52%), Gaps = 12/230 (5%)

Query: 1   MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY 60
           ++ + + S+N     +P    + + + ++ G L L  ++GNILV++S+  +RHL +V +Y
Sbjct: 4   LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63

Query: 61  FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD 120
           ++ +LA ADL++    +    ++ V+GYW  G V C++W A+D +   AS+M L IIS D
Sbjct: 64  YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123

Query: 121 RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF 180
           RY  V+ PL YP   T +   M +   W LS ++    +  W+     +   + E   Q 
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWR-----QPAPEDETICQI 178

Query: 181 FSNAAVTFGTAIAAFYLPVIIMTVLYWHI-------SRASKSRIKKDKKE 223
                    +A+ +FYLP+ I+ V+Y  +       SR  KS +K DK +
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSD 228



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 41/132 (31%), Positives = 66/132 (50%), Gaps = 9/132 (6%)

Query: 325 IRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKK 384
           ++ G KT KSDS   T         +G +G           V++ K         SREKK
Sbjct: 218 LKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKF--------SREKK 269

Query: 385 VTRTILAILLAFIITWAPYNVMVLINTFCAPCIPN-TVWTIGYWLCYINSTINPACYALC 443
             +T+  ++  F++ W P+ +++ I +F     P+ TV+ I +WL Y+NS INP  Y   
Sbjct: 270 AAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCS 329

Query: 444 NATFKKTFKHLL 455
           +  FKK F+++L
Sbjct: 330 SQEFKKAFQNVL 341


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  131 bits (330), Expect = 1e-30
 Identities = 72/207 (34%), Positives = 112/207 (54%), Gaps = 8/207 (3%)

Query: 13  ALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLII 72
           +++ P+K    V +V++   ++L T + N  V+ ++   R L T  NY + SLA  DL++
Sbjct: 43  SISLPWK----VLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLV 98

Query: 73  GVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 132
            +  M + T+YTV G W LG VVCD WL+ D     AS+++L +I+ DRY+ +T  + Y 
Sbjct: 99  SILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYS 158

Query: 133 VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAI 192
            KRT K A +MIA  WV S  +  P   FW+       V   EC +    +   T  + +
Sbjct: 159 AKRTPKRAAVMIALVWVFSISISLPP-FFWRQAKAEEEV--SECVVN-TDHILYTVYSTV 214

Query: 193 AAFYLPVIIMTVLYWHISRASKSRIKK 219
            AFY P +++  LY  I   ++SRI K
Sbjct: 215 GAFYFPTLLLIALYGRIYVEARSRILK 241



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 32/84 (38%), Positives = 47/84 (55%), Gaps = 2/84 (2%)

Query: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFC--APCIPNTVWTIGYWLCYI 431
           KKK   +RE+K T+T+  IL AFI+ W P+ ++ L+   C  A      ++    WL Y+
Sbjct: 301 KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL 360

Query: 432 NSTINPACYALCNATFKKTFKHLL 455
           NS INP  Y + N  FK+ F  L+
Sbjct: 361 NSLINPIIYTMSNEDFKQAFHKLI 384


>gi|32483397 dopamine receptor D4 [Homo sapiens]
          Length = 419

 Score =  127 bits (319), Expect = 2e-29
 Identities = 110/431 (25%), Positives = 182/431 (42%), Gaps = 56/431 (12%)

Query: 28  LVAGSLSLVTII-GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI 86
           LV G L +  ++ GN LV VS+   R LQT  N F+ SLA ADL++ +  + L+    V 
Sbjct: 38  LVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQ 97

Query: 87  G-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIA 145
           G  W L P +CD  +A+D ++  AS+ NL  IS DR+  V  PL Y  +  ++   ++I 
Sbjct: 98  GGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIG 157

Query: 146 AAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVL 205
           A W+LS  + AP       + G+  V   +  +    +      +++ +F+LP  +M +L
Sbjct: 158 ATWLLSAAVAAPV------LCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLL 211

Query: 206 YWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKA 265
           YW   R  + R +  ++  +  + P  PS        P    +P    G +      G  
Sbjct: 212 YWATFRGLQ-RWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPG-L 269

Query: 266 PRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCI 325
           PR P   +C               +  A ++  D    D    +  L             
Sbjct: 270 PRGPCGPDC---------------APAAPSLPQDPCGPDCAPPAPGL------------- 301

Query: 326 RIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKV 385
                 P   +C P +  V       Q   + +    R+  K+T           RE+K 
Sbjct: 302 ---PPDPCGSNCAPPD-AVRAAALPPQTPPQTRR---RRRAKIT----------GRERKA 344

Query: 386 TRTILAILLAFIITWAPYNVMVLINTFCAPC-IPNTVWTIGYWLCYINSTINPACYALCN 444
            R +  ++ AF++ W P+ V+ +    C  C +P  + +   WL Y+NS +NP  Y + N
Sbjct: 345 MRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFN 404

Query: 445 ATFKKTFKHLL 455
           A F+  F+  L
Sbjct: 405 AEFRNVFRKAL 415


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  125 bits (315), Expect = 6e-29
 Identities = 68/216 (31%), Positives = 113/216 (52%), Gaps = 4/216 (1%)

Query: 2   NNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYF 61
           N S N++  S A          + + +V   ++L T++ N  V+ +I + R L T  NY 
Sbjct: 17  NRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYL 76

Query: 62  LFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDR 121
           + SLA  DL++ +  M +   YT+   W  G ++CD+WL+ D     AS+++L +I+ DR
Sbjct: 77  IGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDR 136

Query: 122 YFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFF 181
           Y+ +T  L Y  +RT   A  MIA  W +S  +  P  LFW+       + D  C +   
Sbjct: 137 YWAITDALEYSKRRTAGHAATMIAIVWAISICISIPP-LFWRQAKAQEEMSD--CLVN-T 192

Query: 182 SNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRI 217
           S  + T  +   AFY+P +++ +LY  I RA+++RI
Sbjct: 193 SQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRI 228



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 29/84 (34%), Positives = 47/84 (55%), Gaps = 2/84 (2%)

Query: 374 KKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC--IPNTVWTIGYWLCYI 431
           +K+   +RE+K T+ +  IL AFII W P+ V+ L+   C     I   ++    WL Y+
Sbjct: 288 RKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYL 347

Query: 432 NSTINPACYALCNATFKKTFKHLL 455
           NS INP  Y + N  F++ F+ ++
Sbjct: 348 NSLINPIIYTVFNEEFRQAFQKIV 371


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.133    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,714,878
Number of Sequences: 37866
Number of extensions: 714480
Number of successful extensions: 4585
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 566
Number of HSP's successfully gapped in prelim test: 214
Number of HSP's that attempted gapping in prelim test: 2891
Number of HSP's gapped (non-prelim): 1277
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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