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Search of human proteins with 5454102
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5454102 transforming, acidic coiled-coil containing protein
3 [Homo sapiens]
(838 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5454102 transforming, acidic coiled-coil containing protein 3... 1670 0.0
gi|170763517 transforming, acidic coiled-coil containing protein... 240 5e-63
gi|226246618 transforming, acidic coiled-coil containing protein... 234 2e-61
gi|150418009 transforming, acidic coiled-coil containing protein... 211 2e-54
gi|45827755 transforming, acidic coiled-coil containing protein ... 211 2e-54
gi|45827753 transforming, acidic coiled-coil containing protein ... 211 2e-54
gi|11119414 transforming, acidic coiled-coil containing protein ... 211 2e-54
gi|170763519 transforming, acidic coiled-coil containing protein... 209 1e-53
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 63 1e-09
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 63 1e-09
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 63 1e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 63 1e-09
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 59 2e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 57 5e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 57 9e-08
gi|22749429 coiled-coil domain containing 89 [Homo sapiens] 56 2e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 55 2e-07
gi|51317366 myosin XVIIIB [Homo sapiens] 55 4e-07
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 54 5e-07
gi|118498362 kinectin 1 isoform b [Homo sapiens] 53 1e-06
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 53 1e-06
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 53 1e-06
gi|156104908 myosin heavy chain 6 [Homo sapiens] 53 1e-06
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 52 2e-06
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 52 2e-06
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 52 2e-06
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 52 2e-06
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 52 2e-06
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 52 3e-06
gi|38044112 restin isoform b [Homo sapiens] 51 4e-06
>gi|5454102 transforming, acidic coiled-coil containing protein 3
[Homo sapiens]
Length = 838
Score = 1670 bits (4325), Expect = 0.0
Identities = 838/838 (100%), Positives = 838/838 (100%)
Query: 1 MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTP 60
MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTP
Sbjct: 1 MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTP 60
Query: 61 LRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQK 120
LRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQK
Sbjct: 61 LRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQK 120
Query: 121 PVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQ 180
PVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQ
Sbjct: 121 PVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQ 180
Query: 181 AVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGG 240
AVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGG
Sbjct: 181 AVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGG 240
Query: 241 VCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPE 300
VCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPE
Sbjct: 241 VCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPE 300
Query: 301 STAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGER 360
STAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGER
Sbjct: 301 STAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGER 360
Query: 361 SGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGG 420
SGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGG
Sbjct: 361 SGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGG 420
Query: 421 DTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAE 480
DTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAE
Sbjct: 421 DTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAE 480
Query: 481 TPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDY 540
TPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDY
Sbjct: 481 TPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDY 540
Query: 541 LEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKL 600
LEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKL
Sbjct: 541 LEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKL 600
Query: 601 VEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRS 660
VEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRS
Sbjct: 601 VEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRS 660
Query: 661 RCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEK 720
RCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEK
Sbjct: 661 RCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEK 720
Query: 721 SFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANE 780
SFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANE
Sbjct: 721 SFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANE 780
Query: 781 EIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
EIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI
Sbjct: 781 EIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
>gi|170763517 transforming, acidic coiled-coil containing protein 1
isoform 1 [Homo sapiens]
Length = 805
Score = 240 bits (612), Expect = 5e-63
Identities = 233/775 (30%), Positives = 346/775 (44%), Gaps = 119/775 (15%)
Query: 129 LGDASPAFGSGSSSESGPGALADL--DCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENL 186
LG A P S S E+ +A++ CSS + S SEN++ S S + EE
Sbjct: 82 LGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSK-PSENEVPQQAIDSHSVKNFREEPE 140
Query: 187 SSYSLDRRVTPASETLEDP--------------CRTESQHKA---ETPHGAEEECKAETP 229
+S V P S +D C T KA P ++E E
Sbjct: 141 HDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGS 200
Query: 230 HG------AEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQ--GLPGEALGCPAGV-G 280
G AE + + G C + PK PL+ + GE A V G
Sbjct: 201 MGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPV----PLRKKAIGGEFSDTNAAVEG 256
Query: 281 TPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAM------------TLSPQEEVAAGQMA 328
TP+P H S E T+ L+ TLS + ++
Sbjct: 257 TPLPK------ASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELG 310
Query: 329 SSSRSGPVKLEFDVSD--GATSKRAPPPRRLGERSG--LKPPLRKAAVRQQKAPQEVEED 384
SRS P+KLEFD ++ G R PR+LG + G L P ++K + + ++ +
Sbjct: 311 EESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDP 370
Query: 385 DGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDT---------KSGCSEAQPPESP 435
R G P S+ S D + + P+F PFG + G P
Sbjct: 371 VARDG-------PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFD 423
Query: 436 ETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSAS 495
E+ L + G +++ L S + ++ + E++ AL++ S
Sbjct: 424 ESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACS 483
Query: 496 TSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALR 555
+G ++ + S RD G D + TS ++SA
Sbjct: 484 ---------------RDEGAVISQISDISNRD-------GHATDEEKLASTSCGQKSA-- 519
Query: 556 KQSLYLKFDPL--LRDSPGRPVPVATETSSMHGANETPSGRPREA-KLVEFD---FLGAL 609
+K +P L VPV+T H + + +G +E + +E D LG L
Sbjct: 520 --GAEVKGEPEEDLEYFECSNVPVSTIN---HAFSSSEAGIEKETCQKMEEDGSTVLGLL 574
Query: 610 DIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEE-------NRELRSRC 662
+ P V G PL D + S+ D AV+ +EE E + +
Sbjct: 575 ESSAEKAPVSVSCGGESPL------DGICLSESDKTAVLTLIREEIITKEIEANEWKKKY 628
Query: 663 EELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSF 722
EE + LE+ KI+ +E+ + Q +E+ Q+ S+ Q++ EK+Q DLNS+E+S
Sbjct: 629 EETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSL 688
Query: 723 SDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEI 782
SDLF+R+E K V+EG++KNEE+LKKC +DYLAR+ QE QRYQALK HAEEKL ANEEI
Sbjct: 689 SDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEI 748
Query: 783 AQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK 837
AQVR+KA+AE+ AL A LRKEQM+++SLE+ ++QK +E EELT+ICD+LI+K+ K
Sbjct: 749 AQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGK 803
>gi|226246618 transforming, acidic coiled-coil containing protein 1
isoform 3 [Homo sapiens]
Length = 610
Score = 234 bits (597), Expect = 2e-61
Identities = 180/549 (32%), Positives = 273/549 (49%), Gaps = 68/549 (12%)
Query: 315 TLSPQEEVAAGQMASSSRSGPVKLEFDVSD--GATSKRAPPPRRLGERSG--LKPPLRKA 370
TLS + ++ SRS P+KLEFD ++ G R PR+LG + G L P ++K
Sbjct: 102 TLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKD 161
Query: 371 AVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDT-------- 422
+ + ++ + R G P S+ S D + + P+F PFG +
Sbjct: 162 GISKSAGLEQPTDPVARDG-------PLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPL 214
Query: 423 -KSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAET 481
G P E+ L + G +++ L S + ++ +
Sbjct: 215 SSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKV 274
Query: 482 PTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYL 541
E++ AL++ S +G ++ + S RD G D
Sbjct: 275 KKHETQSLALDACS---------------RDEGAVISQISDISNRD-------GHATDEE 312
Query: 542 EQFGTSSFKESALRKQSLYLKFDPL--LRDSPGRPVPVATETSSMHGANETPSGRPREA- 598
+ TS ++SA +K +P L VPV+T H + + +G +E
Sbjct: 313 KLASTSCGQKSA----GAEVKGEPEEDLEYFECSNVPVSTIN---HAFSSSEAGIEKETC 365
Query: 599 KLVEFD---FLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEE- 654
+ +E D LG L+ P V G PL D + S+ D AV+ +EE
Sbjct: 366 QKMEEDGSTVLGLLESSAEKAPVSVSCGGESPL------DGICLSESDKTAVLTLIREEI 419
Query: 655 ------NRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEK 708
E + + EE + LE+ KI+ +E+ + Q +E+ Q+ S+ Q++ EK
Sbjct: 420 ITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEK 479
Query: 709 DQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALK 768
+Q DLNS+E+S SDLF+R+E K V+EG++KNEE+LKKC +DYLAR+ QE QRYQALK
Sbjct: 480 EQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALK 539
Query: 769 AHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRIC 828
HAEEKL ANEEIAQVR+KA+AE+ AL A LRKEQM+++SLE+ ++QK +E EELT+IC
Sbjct: 540 IHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKIC 599
Query: 829 DDLISKMEK 837
D+LI+K+ K
Sbjct: 600 DELIAKLGK 608
Score = 32.7 bits (73), Expect = 1.4
Identities = 37/144 (25%), Positives = 57/144 (39%), Gaps = 15/144 (10%)
Query: 339 EFDVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPA 398
E D+ G + P RR R PLRK A+ E + A E P+P
Sbjct: 15 EADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIG--------GEFSDTNAAVEGTPLP- 65
Query: 399 SRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGP 458
+ SYH +++D+ N P GD + + PP+ ET G +++ +G E
Sbjct: 66 -KASYHFSPEELDE-NTSPLLGDAR---FQKSPPDLKETP-GTLSSDTNDSGVELGEESR 119
Query: 459 CLSQQLHSASAEDTPVVQLAAETP 482
+L EDT ++ P
Sbjct: 120 SSPLKLEFDFTEDTGNIEARKALP 143
>gi|150418009 transforming, acidic coiled-coil containing protein 2
isoform a [Homo sapiens]
Length = 2948
Score = 211 bits (537), Expect = 2e-54
Identities = 107/208 (51%), Positives = 151/208 (72%), Gaps = 7/208 (3%)
Query: 637 LQYSQKDLDAVVKAT-------QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE 689
L + Q DLD+ ++ + E E + + EE + +E+ KI+ +E+ + Q +E+
Sbjct: 2740 LLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIED 2799
Query: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
Q++K +S +Q+++ EK+Q DLNS+EKS +DLF+R+EK KEV+EG+RKNEE LK+C
Sbjct: 2800 EQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRC 2859
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
++YL+R+ +E QRYQALK HAEEKL AN EIAQVR KAQ E A QASLRKEQ+R+ +
Sbjct: 2860 AQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDA 2919
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
LE+T+EQK KE EELT+ICD+LI+KM K
Sbjct: 2920 LERTLEQKNKEIEELTKICDELIAKMGK 2947
Score = 102 bits (254), Expect = 1e-21
Identities = 192/868 (22%), Positives = 329/868 (37%), Gaps = 177/868 (20%)
Query: 95 PVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDC 154
P + +NQ+ K+T + L AS G+ SS ALA
Sbjct: 2054 PRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAY 2113
Query: 155 SSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKA 214
S+ S S S+ + P S +Q ++ + P ET ++P ++
Sbjct: 2114 STGSSSASSTLKRTKKPRPPSLKKKQTTKKPTET-------PPVKETQQEP-----DEES 2161
Query: 215 ETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSP--PGAIPKEACGGAPLQGLPGEA 272
P G + +T E +PA + +P P PK AC PL E
Sbjct: 2162 LVPSGENLASETKTESAKTEGP------SPALLEETPLEPAVGPKAAC---PLDSESAEG 2212
Query: 273 LGCPAGVGTPV---PADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMAS 329
+ PA G V P G +TL P +TAP A ++P + + GQ S
Sbjct: 2213 VVPPASGGGRVQNSPPVGRKTL-------PLTTAP-------EAGEVTPSD--SGGQEDS 2256
Query: 330 SSRSGPVKLEFDVSDGATS-----KRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEED 384
++ V+LEFD S+ +S + PP +++G++ K PLR+ + +K P++++
Sbjct: 2257 PAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRP--KMKKTPEKLDNT 2314
Query: 385 DG---RSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTK----------------SG 425
RS A E +P ++G+Y D DK DDPNF PF +K
Sbjct: 2315 PASPPRSPA-EPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDT 2373
Query: 426 CSEAQPP-----ESPETRLGQPAAEQLHAG--------------PATEEPGPCL------ 460
C E+ P ++P + PA+ ++ A PA ++ P
Sbjct: 2374 CDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRV 2433
Query: 461 -------------SQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEP 507
SQ A+ +TP V A T E K N T + ++
Sbjct: 2434 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE-ADK 2492
Query: 508 VPTHQQGQPALELKEESFRDPAEVLG--TGAEVDYLEQFGTS-SFKESALRKQSLYLKFD 564
Q + + E F P E L E++Y+E+ G+S + A +KQ+LYL FD
Sbjct: 2493 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 2552
Query: 565 PLLRDSPGRPVPVATETS----------------SMHGANETPSGR------------PR 596
++SP + PV S + N+ P R P
Sbjct: 2553 -TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPE 2611
Query: 597 EAKLVEFDFLGALDIPVPGPPPGVPAPGGP-------------PLSTGPIVDLLQ--YSQ 641
++ E + +G + P + AP G P+S +D L+ ++
Sbjct: 2612 KSSQKELEAMG---LGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAE 2668
Query: 642 KDLDAVVKATQEENRELRSRCEELH-GKNLELG--KIMDRFEEVVYQAMEEVQK---QKE 695
K+ + QEE R E L + + L D E + + K
Sbjct: 2669 KNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSR 2728
Query: 696 LSKAEIQK---VLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+ AE++K +L ++ L + L + + K+ E R+ ++K V +
Sbjct: 2729 IGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAE 2788
Query: 753 Y---LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
Y +A++ ++ QR +++ ++L L E+ A A+ +++ SL R +
Sbjct: 2789 YEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ-------ALADLNSVEKSLADLFRRYEK 2841
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
+++ +E K E L R + +S+++K
Sbjct: 2842 MKEVLEGFRKNEEVLKRCAQEYLSRVKK 2869
Score = 42.0 bits (97), Expect = 0.002
Identities = 107/438 (24%), Positives = 153/438 (34%), Gaps = 102/438 (23%)
Query: 100 KENQQLIKEVDAKTTHGILQKPVEADTDLLGDAS-------PAFGSGSSSESGPGALADL 152
++ QQL E A+ +H LQ P A LLG A P G G P L +
Sbjct: 1473 EKKQQLAGE--AEISHLALQDP--ASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLRE- 1527
Query: 153 DCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPC-RTESQ 211
+ PG++ + G+ E++ +E S +PA+ T E P R +
Sbjct: 1528 --DERPEGPGAAWPGL--EGQAYSQLERSRQELASGLP-----SPAA-TQELPVERAAAF 1577
Query: 212 HKAETPHGAEEECKAETPHGAEEE------CRHGGVCAPAAVATSPPGAIPKEACGGAP- 264
A HG E + P G + + HG T PG +P+ C +P
Sbjct: 1578 QVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQ 1637
Query: 265 ---------------LQGLPGEAL-GCPAGVGTPVPADGTQTLTCAHTSAPESTAPTNHL 308
L L GE G AG+ A G Q+ T T
Sbjct: 1638 REVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGK 1697
Query: 309 VAGRA------MTLSPQEE--VAAGQM--ASSSRS-----GPVKLEFDVSDGATSKRAPP 353
VAG A +TLS E A+G + A ++R+ G + L D A S +AP
Sbjct: 1698 VAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPG 1757
Query: 354 PRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDP 413
G P PQ+ +E G + P+PA G +
Sbjct: 1758 MEGTAALHGDSPA----------RPQQAKEQPG-----PERPIPAGDGKVCVS------- 1795
Query: 414 NFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTP 473
S +P E+ + +L A E+LH + PGP + L S +D P
Sbjct: 1796 -------------SPPEPDETHDPKLQHLAPEELHTDRESPRPGPSM---LPSVPKKDAP 1839
Query: 474 VVQ---LAAETPTAESKE 488
V + ET AE E
Sbjct: 1840 RVMDKVTSDETRGAEGTE 1857
Score = 40.0 bits (92), Expect = 0.009
Identities = 118/542 (21%), Positives = 179/542 (33%), Gaps = 101/542 (18%)
Query: 157 SSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLE-DPCR-----TES 210
S+Q PG+S+N GSP+ ++ S L T + + DPC TE
Sbjct: 21 SAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEP 80
Query: 211 QHKAETPHGAEEECKAETPHGAEE----------EC-RHGGVCAPAAV------------ 247
+ + G E P E EC G + +PAA
Sbjct: 81 RKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRR 140
Query: 248 --ATSPPG----AIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPES 301
A + PG A P E P Q E P+ P + Q + + +S +
Sbjct: 141 EPAPNAPGDIAAAFPAERDSSTPYQ----EIAAVPSAGRERQPKEEGQKSSFSFSSGIDQ 196
Query: 302 TAPTNHLVAGRAMTL-------------SPQEEVAAGQMASSSRSGPVKLEFDVSDGATS 348
+ + + M S ++E A G + SR G ++ A +
Sbjct: 197 SPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAA 256
Query: 349 KRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWD 408
++ + E+S LKP A + Q AP+ D G GE PP + D
Sbjct: 257 QQGTESSAVLEKSPLKP---MAPIPQDPAPR---ASDRERGQGEAPPQYLT--------D 302
Query: 409 KMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQL-HAGPATEEPGPCLSQQLHSA 467
++ EA+ + + QP L HA P P L + +
Sbjct: 303 DLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGS 362
Query: 468 SAE--DTPVVQLAAETPTAESKER------ALNSASTSLPTSCPGSEPVPTHQQGQPALE 519
E DT VQ +T +K A LP S S PT ++ PA
Sbjct: 363 GKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPT-EEAHPASS 421
Query: 520 LKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVAT 579
L SF PA + +E+ G+SS ++ K + + D V +
Sbjct: 422 L--ASF--PAAQIPIA-----VEEPGSSS--RESVSKAGMPVSADAAKEVVDAGLVGLER 470
Query: 580 ETSSMHGANETPSGRPREAKLVEFDFLG-------ALDIPVPGPPPGVP-------APGG 625
+ S + E P G P E G + ++ PPP +P PG
Sbjct: 471 QVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGA 530
Query: 626 PP 627
PP
Sbjct: 531 PP 532
>gi|45827755 transforming, acidic coiled-coil containing protein 2
isoform b [Homo sapiens]
Length = 1094
Score = 211 bits (537), Expect = 2e-54
Identities = 107/208 (51%), Positives = 151/208 (72%), Gaps = 7/208 (3%)
Query: 637 LQYSQKDLDAVVKAT-------QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE 689
L + Q DLD+ ++ + E E + + EE + +E+ KI+ +E+ + Q +E+
Sbjct: 886 LLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIED 945
Query: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
Q++K +S +Q+++ EK+Q DLNS+EKS +DLF+R+EK KEV+EG+RKNEE LK+C
Sbjct: 946 EQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRC 1005
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
++YL+R+ +E QRYQALK HAEEKL AN EIAQVR KAQ E A QASLRKEQ+R+ +
Sbjct: 1006 AQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDA 1065
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
LE+T+EQK KE EELT+ICD+LI+KM K
Sbjct: 1066 LERTLEQKNKEIEELTKICDELIAKMGK 1093
Score = 102 bits (254), Expect = 1e-21
Identities = 192/868 (22%), Positives = 329/868 (37%), Gaps = 177/868 (20%)
Query: 95 PVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDC 154
P + +NQ+ K+T + L AS G+ SS ALA
Sbjct: 200 PRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAY 259
Query: 155 SSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKA 214
S+ S S S+ + P S +Q ++ + P ET ++P ++
Sbjct: 260 STGSSSASSTLKRTKKPRPPSLKKKQTTKKPTET-------PPVKETQQEP-----DEES 307
Query: 215 ETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSP--PGAIPKEACGGAPLQGLPGEA 272
P G + +T E +PA + +P P PK AC PL E
Sbjct: 308 LVPSGENLASETKTESAKTEGP------SPALLEETPLEPAVGPKAAC---PLDSESAEG 358
Query: 273 LGCPAGVGTPV---PADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMAS 329
+ PA G V P G +TL P +TAP A ++P + + GQ S
Sbjct: 359 VVPPASGGGRVQNSPPVGRKTL-------PLTTAP-------EAGEVTPSD--SGGQEDS 402
Query: 330 SSRSGPVKLEFDVSDGATS-----KRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEED 384
++ V+LEFD S+ +S + PP +++G++ K PLR+ + +K P++++
Sbjct: 403 PAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRP--KMKKTPEKLDNT 460
Query: 385 DG---RSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTK----------------SG 425
RS A E +P ++G+Y D DK DDPNF PF +K
Sbjct: 461 PASPPRSPA-EPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDT 519
Query: 426 CSEAQPP-----ESPETRLGQPAAEQLHAG--------------PATEEPGPCL------ 460
C E+ P ++P + PA+ ++ A PA ++ P
Sbjct: 520 CDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRV 579
Query: 461 -------------SQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEP 507
SQ A+ +TP V A T E K N T + ++
Sbjct: 580 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE-ADK 638
Query: 508 VPTHQQGQPALELKEESFRDPAEVLG--TGAEVDYLEQFGTS-SFKESALRKQSLYLKFD 564
Q + + E F P E L E++Y+E+ G+S + A +KQ+LYL FD
Sbjct: 639 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 698
Query: 565 PLLRDSPGRPVPVATETS----------------SMHGANETPSGR------------PR 596
++SP + PV S + N+ P R P
Sbjct: 699 -TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPE 757
Query: 597 EAKLVEFDFLGALDIPVPGPPPGVPAPGGP-------------PLSTGPIVDLLQ--YSQ 641
++ E + +G + P + AP G P+S +D L+ ++
Sbjct: 758 KSSQKELEAMG---LGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAE 814
Query: 642 KDLDAVVKATQEENRELRSRCEELH-GKNLELG--KIMDRFEEVVYQAMEEVQK---QKE 695
K+ + QEE R E L + + L D E + + K
Sbjct: 815 KNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSR 874
Query: 696 LSKAEIQK---VLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+ AE++K +L ++ L + L + + K+ E R+ ++K V +
Sbjct: 875 IGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAE 934
Query: 753 Y---LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
Y +A++ ++ QR +++ ++L L E+ A A+ +++ SL R +
Sbjct: 935 YEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ-------ALADLNSVEKSLADLFRRYEK 987
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
+++ +E K E L R + +S+++K
Sbjct: 988 MKEVLEGFRKNEEVLKRCAQEYLSRVKK 1015
Score = 39.7 bits (91), Expect = 0.012
Identities = 94/429 (21%), Positives = 145/429 (33%), Gaps = 75/429 (17%)
Query: 157 SSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASET-LEDPCRTESQHKAE 215
S+Q PG+S+N GSP+ + SS D + PA+ LE P S + +
Sbjct: 21 SAQPPGNSQNIKRKQQDTPGSPDH--RDASSSPVADDIIQPAAPADLESPTLAASSYHGD 78
Query: 216 TPHGAEEECKAETPHGAEEECR----HGGVCAPAAVATSPPGAIPKEACGGAPLQGLPG- 270
+ A+ +EE V AP A PP IP+ P PG
Sbjct: 79 VVGQVSTDLIAQRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGC 138
Query: 271 --EALGCPAG------VGTPVPADGTQTLTCAHTSAPESTAPTNHL------VAGRAMTL 316
E + P G G+P P +++ T +L + TL
Sbjct: 139 GSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTL 198
Query: 317 SPQEEVAAGQ---------------MASSSRSGPVKLEFDVSDGATSKRAPPPRRLGE-- 359
P+ A Q ++ S+ S + L+ DGA+S P L
Sbjct: 199 EPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDA 258
Query: 360 -RSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPF 418
+G ++ P +++ E PP+ ++ + D+ + +P
Sbjct: 259 YSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQ-------QEPDEESLVP- 310
Query: 419 GGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLA 478
SG + A ++ + P+ L P GP + L S SAE
Sbjct: 311 -----SGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGV------ 359
Query: 479 AETPTAESKERALNS-----ASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLG 533
P A R NS + L T+ E P+ GQ E+S PA+ L
Sbjct: 360 --VPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQ------EDS---PAKGLS 408
Query: 534 TGAEVDYLE 542
E DY E
Sbjct: 409 VRLEFDYSE 417
>gi|45827753 transforming, acidic coiled-coil containing protein 2
isoform c [Homo sapiens]
Length = 996
Score = 211 bits (537), Expect = 2e-54
Identities = 107/208 (51%), Positives = 151/208 (72%), Gaps = 7/208 (3%)
Query: 637 LQYSQKDLDAVVKAT-------QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE 689
L + Q DLD+ ++ + E E + + EE + +E+ KI+ +E+ + Q +E+
Sbjct: 788 LLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIED 847
Query: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
Q++K +S +Q+++ EK+Q DLNS+EKS +DLF+R+EK KEV+EG+RKNEE LK+C
Sbjct: 848 EQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRC 907
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
++YL+R+ +E QRYQALK HAEEKL AN EIAQVR KAQ E A QASLRKEQ+R+ +
Sbjct: 908 AQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDA 967
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
LE+T+EQK KE EELT+ICD+LI+KM K
Sbjct: 968 LERTLEQKNKEIEELTKICDELIAKMGK 995
>gi|11119414 transforming, acidic coiled-coil containing protein 2
isoform d [Homo sapiens]
Length = 1026
Score = 211 bits (537), Expect = 2e-54
Identities = 107/208 (51%), Positives = 151/208 (72%), Gaps = 7/208 (3%)
Query: 637 LQYSQKDLDAVVKAT-------QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE 689
L + Q DLD+ ++ + E E + + EE + +E+ KI+ +E+ + Q +E+
Sbjct: 818 LLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIED 877
Query: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
Q++K +S +Q+++ EK+Q DLNS+EKS +DLF+R+EK KEV+EG+RKNEE LK+C
Sbjct: 878 EQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRC 937
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
++YL+R+ +E QRYQALK HAEEKL AN EIAQVR KAQ E A QASLRKEQ+R+ +
Sbjct: 938 AQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDA 997
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
LE+T+EQK KE EELT+ICD+LI+KM K
Sbjct: 998 LERTLEQKNKEIEELTKICDELIAKMGK 1025
Score = 102 bits (254), Expect = 1e-21
Identities = 192/868 (22%), Positives = 329/868 (37%), Gaps = 177/868 (20%)
Query: 95 PVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDC 154
P + +NQ+ K+T + L AS G+ SS ALA
Sbjct: 132 PRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAY 191
Query: 155 SSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKA 214
S+ S S S+ + P S +Q ++ + P ET ++P ++
Sbjct: 192 STGSSSASSTLKRTKKPRPPSLKKKQTTKKPTET-------PPVKETQQEP-----DEES 239
Query: 215 ETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSP--PGAIPKEACGGAPLQGLPGEA 272
P G + +T E +PA + +P P PK AC PL E
Sbjct: 240 LVPSGENLASETKTESAKTEGP------SPALLEETPLEPAVGPKAAC---PLDSESAEG 290
Query: 273 LGCPAGVGTPV---PADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMAS 329
+ PA G V P G +TL P +TAP A ++P + + GQ S
Sbjct: 291 VVPPASGGGRVQNSPPVGRKTL-------PLTTAP-------EAGEVTPSD--SGGQEDS 334
Query: 330 SSRSGPVKLEFDVSDGATS-----KRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEED 384
++ V+LEFD S+ +S + PP +++G++ K PLR+ + +K P++++
Sbjct: 335 PAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRP--KMKKTPEKLDNT 392
Query: 385 DG---RSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTK----------------SG 425
RS A E +P ++G+Y D DK DDPNF PF +K
Sbjct: 393 PASPPRSPA-EPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDT 451
Query: 426 CSEAQPP-----ESPETRLGQPAAEQLHAG--------------PATEEPGPCL------ 460
C E+ P ++P + PA+ ++ A PA ++ P
Sbjct: 452 CDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRV 511
Query: 461 -------------SQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEP 507
SQ A+ +TP V A T E K N T + ++
Sbjct: 512 KKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLE-ADK 570
Query: 508 VPTHQQGQPALELKEESFRDPAEVLG--TGAEVDYLEQFGTS-SFKESALRKQSLYLKFD 564
Q + + E F P E L E++Y+E+ G+S + A +KQ+LYL FD
Sbjct: 571 QDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFD 630
Query: 565 PLLRDSPGRPVPVATETS----------------SMHGANETPSGR------------PR 596
++SP + PV S + N+ P R P
Sbjct: 631 -TSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPE 689
Query: 597 EAKLVEFDFLGALDIPVPGPPPGVPAPGGP-------------PLSTGPIVDLLQ--YSQ 641
++ E + +G + P + AP G P+S +D L+ ++
Sbjct: 690 KSSQKELEAMG---LGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAE 746
Query: 642 KDLDAVVKATQEENRELRSRCEELH-GKNLELG--KIMDRFEEVVYQAMEEVQK---QKE 695
K+ + QEE R E L + + L D E + + K
Sbjct: 747 KNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSR 806
Query: 696 LSKAEIQK---VLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+ AE++K +L ++ L + L + + K+ E R+ ++K V +
Sbjct: 807 IGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAE 866
Query: 753 Y---LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
Y +A++ ++ QR +++ ++L L E+ A A+ +++ SL R +
Sbjct: 867 YEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ-------ALADLNSVEKSLADLFRRYEK 919
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEK 837
+++ +E K E L R + +S+++K
Sbjct: 920 MKEVLEGFRKNEEVLKRCAQEYLSRVKK 947
>gi|170763519 transforming, acidic coiled-coil containing protein 1
isoform 2 [Homo sapiens]
Length = 395
Score = 209 bits (531), Expect = 1e-53
Identities = 123/274 (44%), Positives = 174/274 (63%), Gaps = 20/274 (7%)
Query: 575 VPVATETSSMHGANETPSGRPREA-KLVEFD---FLGALDIPVPGPPPGVPAPGGPPLST 630
VPV+T H + + +G +E + +E D LG L+ P V G PL
Sbjct: 129 VPVSTIN---HAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPL-- 183
Query: 631 GPIVDLLQYSQKDLDAVVKATQEE-------NRELRSRCEELHGKNLELGKIMDRFEEVV 683
D + S+ D AV+ +EE E + + EE + LE+ KI+ +E+ +
Sbjct: 184 ----DGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTI 239
Query: 684 YQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNE 743
Q +E+ Q+ S+ Q++ EK+Q DLNS+E+S SDLF+R+E K V+EG++KNE
Sbjct: 240 AQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNE 299
Query: 744 ESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKE 803
E+LKKC +DYLAR+ QE QRYQALK HAEEKL ANEEIAQVR+KA+AE+ AL A LRKE
Sbjct: 300 EALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKE 359
Query: 804 QMRIQSLEKTVEQKTKENEELTRICDDLISKMEK 837
QM+++SLE+ ++QK +E EELT+ICD+LI+K+ K
Sbjct: 360 QMKVESLERALQQKNQEIEELTKICDELIAKLGK 393
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 62.8 bits (151), Expect = 1e-09
Identities = 106/516 (20%), Positives = 180/516 (34%), Gaps = 78/516 (15%)
Query: 70 LSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLL 129
L SM K +A + G HP + L + K+ + ++T+
Sbjct: 117 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE 176
Query: 130 GDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSS- 188
G PAFG+ + PG ++ SSS+ SS ++ GK S P Q ++S+
Sbjct: 177 GSV-PAFGAAAK----PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 189 YSLDRRVTPASETLED----------PCRTESQHKAETPHGAEE--ECKAETPHGAEEEC 236
S R+ PA + D P ++ E +EE E + E P G +
Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291
Query: 237 RHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHT 296
+ A++P P + AP PG+A + P + +++ + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESS 347
Query: 297 SAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSG-----PVKLEFDVSDGATSKRA 351
+ E T L+ +A + Q A+ S R G P K V+ KR
Sbjct: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 352 PPPRRLGERSGLKPPLRKAAVRQQKAPQ-----EVEEDDGRSGAGEDPPMPASRGSYHLD 406
+ E S + A KAPQ ++ R GA PP + +
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ 467
Query: 407 WDKMDDPNFIPFGGDTKSGCSEAQPP----------------ESPETRLGQPAAEQLHAG 450
K ++ D++S E+ +SP+ + A + G
Sbjct: 468 VGKQEE--------DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK----PASTMGMG 515
Query: 451 PATEEPGPC----------------LSQQLHSASAEDTPVVQLAAETPTAESKERALNSA 494
P + GP + S+S E + T A ++E++L +
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575
Query: 495 STSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAE 530
+ PTS P P + G A+++K E D +E
Sbjct: 576 LQAKPTSSPAKG--PPQKAGPVAVQVKAEKPMDNSE 609
Score = 40.8 bits (94), Expect = 0.005
Identities = 114/534 (21%), Positives = 179/534 (33%), Gaps = 106/534 (19%)
Query: 119 QKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCS------SSSQSPGSSENQMVSP- 171
++ EA+T A+P S +SS G ADL S + ++ G + N M P
Sbjct: 91 EEEAEAET---AKATPRLASTNSSVLG----ADLPSSMKEKAKAETEKAGKTGNSMPHPA 143
Query: 172 -GK-----VSG-SPEQAVEENLSSYSLDRRVTPASETLED---PCRTESQHKAETPHGAE 221
GK +SG SP ++ E + ++ T SET E+ P + G
Sbjct: 144 TGKTVANLLSGKSPRKSAEPSANT-------TLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 222 EECKAETPHGAEEECRHGGVCA-PAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVG 280
+ +T ++E G PA V S A AP G G+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 281 TPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEF 340
P PA + S+ E + AG + E++ + AS+ G
Sbjct: 257 LP-PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP---- 311
Query: 341 DVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKA--PQEVEEDDGRSGAGEDPPMPA 398
GAT PP + G A Q KA P+E E + + PA
Sbjct: 312 --GKGATPA---PPGKAG-----------AVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 399 SRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGP 458
++ G ++ G + A ESP R G A GPA +
Sbjct: 356 AKALLQAKAS----------GKTSQVGAASAPAKESP--RKGAAPAPPGKTGPAVAKAQA 403
Query: 459 CLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSC-PGSEPVPTHQQGQPA 517
++ +S+E++ + A K + +AS S G+ P P + G A
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
Query: 518 LELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPV 577
++ +V E+ SS +ES +++L
Sbjct: 464 AQV----------------QVGKQEEDSRSSSEESDSDREAL------------------ 489
Query: 578 ATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTG 631
++M+ A P G+ + K +G L PPG P P G
Sbjct: 490 ----AAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVG 539
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 62.8 bits (151), Expect = 1e-09
Identities = 106/516 (20%), Positives = 180/516 (34%), Gaps = 78/516 (15%)
Query: 70 LSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLL 129
L SM K +A + G HP + L + K+ + ++T+
Sbjct: 117 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE 176
Query: 130 GDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSS- 188
G PAFG+ + PG ++ SSS+ SS ++ GK S P Q ++S+
Sbjct: 177 GSV-PAFGAAAK----PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 189 YSLDRRVTPASETLED----------PCRTESQHKAETPHGAEE--ECKAETPHGAEEEC 236
S R+ PA + D P ++ E +EE E + E P G +
Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291
Query: 237 RHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHT 296
+ A++P P + AP PG+A + P + +++ + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESS 347
Query: 297 SAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSG-----PVKLEFDVSDGATSKRA 351
+ E T L+ +A + Q A+ S R G P K V+ KR
Sbjct: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 352 PPPRRLGERSGLKPPLRKAAVRQQKAPQ-----EVEEDDGRSGAGEDPPMPASRGSYHLD 406
+ E S + A KAPQ ++ R GA PP + +
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ 467
Query: 407 WDKMDDPNFIPFGGDTKSGCSEAQPP----------------ESPETRLGQPAAEQLHAG 450
K ++ D++S E+ +SP+ + A + G
Sbjct: 468 VGKQEE--------DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK----PASTMGMG 515
Query: 451 PATEEPGPC----------------LSQQLHSASAEDTPVVQLAAETPTAESKERALNSA 494
P + GP + S+S E + T A ++E++L +
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575
Query: 495 STSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAE 530
+ PTS P P + G A+++K E D +E
Sbjct: 576 LQAKPTSSPAKG--PPQKAGPVAVQVKAEKPMDNSE 609
Score = 40.8 bits (94), Expect = 0.005
Identities = 114/534 (21%), Positives = 179/534 (33%), Gaps = 106/534 (19%)
Query: 119 QKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCS------SSSQSPGSSENQMVSP- 171
++ EA+T A+P S +SS G ADL S + ++ G + N M P
Sbjct: 91 EEEAEAET---AKATPRLASTNSSVLG----ADLPSSMKEKAKAETEKAGKTGNSMPHPA 143
Query: 172 -GK-----VSG-SPEQAVEENLSSYSLDRRVTPASETLED---PCRTESQHKAETPHGAE 221
GK +SG SP ++ E + ++ T SET E+ P + G
Sbjct: 144 TGKTVANLLSGKSPRKSAEPSANT-------TLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 222 EECKAETPHGAEEECRHGGVCA-PAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVG 280
+ +T ++E G PA V S A AP G G+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 281 TPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEF 340
P PA + S+ E + AG + E++ + AS+ G
Sbjct: 257 LP-PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP---- 311
Query: 341 DVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKA--PQEVEEDDGRSGAGEDPPMPA 398
GAT PP + G A Q KA P+E E + + PA
Sbjct: 312 --GKGATPA---PPGKAG-----------AVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 399 SRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGP 458
++ G ++ G + A ESP R G A GPA +
Sbjct: 356 AKALLQAKAS----------GKTSQVGAASAPAKESP--RKGAAPAPPGKTGPAVAKAQA 403
Query: 459 CLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSC-PGSEPVPTHQQGQPA 517
++ +S+E++ + A K + +AS S G+ P P + G A
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
Query: 518 LELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPV 577
++ +V E+ SS +ES +++L
Sbjct: 464 AQV----------------QVGKQEEDSRSSSEESDSDREAL------------------ 489
Query: 578 ATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTG 631
++M+ A P G+ + K +G L PPG P P G
Sbjct: 490 ----AAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVG 539
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 62.8 bits (151), Expect = 1e-09
Identities = 106/516 (20%), Positives = 180/516 (34%), Gaps = 78/516 (15%)
Query: 70 LSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLL 129
L SM K +A + G HP + L + K+ + ++T+
Sbjct: 117 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE 176
Query: 130 GDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSS- 188
G PAFG+ + PG ++ SSS+ SS ++ GK S P Q ++S+
Sbjct: 177 GSV-PAFGAAAK----PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 189 YSLDRRVTPASETLED----------PCRTESQHKAETPHGAEE--ECKAETPHGAEEEC 236
S R+ PA + D P ++ E +EE E + E P G +
Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291
Query: 237 RHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHT 296
+ A++P P + AP PG+A + P + +++ + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESS 347
Query: 297 SAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSG-----PVKLEFDVSDGATSKRA 351
+ E T L+ +A + Q A+ S R G P K V+ KR
Sbjct: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 352 PPPRRLGERSGLKPPLRKAAVRQQKAPQ-----EVEEDDGRSGAGEDPPMPASRGSYHLD 406
+ E S + A KAPQ ++ R GA PP + +
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ 467
Query: 407 WDKMDDPNFIPFGGDTKSGCSEAQPP----------------ESPETRLGQPAAEQLHAG 450
K ++ D++S E+ +SP+ + A + G
Sbjct: 468 VGKQEE--------DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK----PASTMGMG 515
Query: 451 PATEEPGPC----------------LSQQLHSASAEDTPVVQLAAETPTAESKERALNSA 494
P + GP + S+S E + T A ++E++L +
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575
Query: 495 STSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAE 530
+ PTS P P + G A+++K E D +E
Sbjct: 576 LQAKPTSSPAKG--PPQKAGPVAVQVKAEKPMDNSE 609
Score = 40.8 bits (94), Expect = 0.005
Identities = 114/534 (21%), Positives = 179/534 (33%), Gaps = 106/534 (19%)
Query: 119 QKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCS------SSSQSPGSSENQMVSP- 171
++ EA+T A+P S +SS G ADL S + ++ G + N M P
Sbjct: 91 EEEAEAET---AKATPRLASTNSSVLG----ADLPSSMKEKAKAETEKAGKTGNSMPHPA 143
Query: 172 -GK-----VSG-SPEQAVEENLSSYSLDRRVTPASETLED---PCRTESQHKAETPHGAE 221
GK +SG SP ++ E + ++ T SET E+ P + G
Sbjct: 144 TGKTVANLLSGKSPRKSAEPSANT-------TLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 222 EECKAETPHGAEEECRHGGVCA-PAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVG 280
+ +T ++E G PA V S A AP G G+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 281 TPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEF 340
P PA + S+ E + AG + E++ + AS+ G
Sbjct: 257 LP-PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP---- 311
Query: 341 DVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKA--PQEVEEDDGRSGAGEDPPMPA 398
GAT PP + G A Q KA P+E E + + PA
Sbjct: 312 --GKGATPA---PPGKAG-----------AVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 399 SRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGP 458
++ G ++ G + A ESP R G A GPA +
Sbjct: 356 AKALLQAKAS----------GKTSQVGAASAPAKESP--RKGAAPAPPGKTGPAVAKAQA 403
Query: 459 CLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSC-PGSEPVPTHQQGQPA 517
++ +S+E++ + A K + +AS S G+ P P + G A
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
Query: 518 LELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPV 577
++ +V E+ SS +ES +++L
Sbjct: 464 AQV----------------QVGKQEEDSRSSSEESDSDREAL------------------ 489
Query: 578 ATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTG 631
++M+ A P G+ + K +G L PPG P P G
Sbjct: 490 ----AAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVG 539
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 62.8 bits (151), Expect = 1e-09
Identities = 106/516 (20%), Positives = 180/516 (34%), Gaps = 78/516 (15%)
Query: 70 LSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLL 129
L SM K +A + G HP + L + K+ + ++T+
Sbjct: 117 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE 176
Query: 130 GDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSS- 188
G PAFG+ + PG ++ SSS+ SS ++ GK S P Q ++S+
Sbjct: 177 GSV-PAFGAAAK----PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 189 YSLDRRVTPASETLED----------PCRTESQHKAETPHGAEE--ECKAETPHGAEEEC 236
S R+ PA + D P ++ E +EE E + E P G +
Sbjct: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV 291
Query: 237 RHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHT 296
+ A++P P + AP PG+A + P + +++ + +
Sbjct: 292 KASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEEDSESSSEESS 347
Query: 297 SAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSG-----PVKLEFDVSDGATSKRA 351
+ E T L+ +A + Q A+ S R G P K V+ KR
Sbjct: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 352 PPPRRLGERSGLKPPLRKAAVRQQKAPQ-----EVEEDDGRSGAGEDPPMPASRGSYHLD 406
+ E S + A KAPQ ++ R GA PP + +
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ 467
Query: 407 WDKMDDPNFIPFGGDTKSGCSEAQPP----------------ESPETRLGQPAAEQLHAG 450
K ++ D++S E+ +SP+ + A + G
Sbjct: 468 VGKQEE--------DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK----PASTMGMG 515
Query: 451 PATEEPGPC----------------LSQQLHSASAEDTPVVQLAAETPTAESKERALNSA 494
P + GP + S+S E + T A ++E++L +
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNI 575
Query: 495 STSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAE 530
+ PTS P P + G A+++K E D +E
Sbjct: 576 LQAKPTSSPAKG--PPQKAGPVAVQVKAEKPMDNSE 609
Score = 40.8 bits (94), Expect = 0.005
Identities = 114/534 (21%), Positives = 179/534 (33%), Gaps = 106/534 (19%)
Query: 119 QKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCS------SSSQSPGSSENQMVSP- 171
++ EA+T A+P S +SS G ADL S + ++ G + N M P
Sbjct: 91 EEEAEAET---AKATPRLASTNSSVLG----ADLPSSMKEKAKAETEKAGKTGNSMPHPA 143
Query: 172 -GK-----VSG-SPEQAVEENLSSYSLDRRVTPASETLED---PCRTESQHKAETPHGAE 221
GK +SG SP ++ E + ++ T SET E+ P + G
Sbjct: 144 TGKTVANLLSGKSPRKSAEPSANT-------TLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
Query: 222 EECKAETPHGAEEECRHGGVCA-PAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVG 280
+ +T ++E G PA V S A AP G G+ G
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Query: 281 TPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEF 340
P PA + S+ E + AG + E++ + AS+ G
Sbjct: 257 LP-PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP---- 311
Query: 341 DVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKA--PQEVEEDDGRSGAGEDPPMPA 398
GAT PP + G A Q KA P+E E + + PA
Sbjct: 312 --GKGATPA---PPGKAG-----------AVASQTKAGKPEEDSESSSEESSDSEEETPA 355
Query: 399 SRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGP 458
++ G ++ G + A ESP R G A GPA +
Sbjct: 356 AKALLQAKAS----------GKTSQVGAASAPAKESP--RKGAAPAPPGKTGPAVAKAQA 403
Query: 459 CLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSC-PGSEPVPTHQQGQPA 517
++ +S+E++ + A K + +AS S G+ P P + G A
Sbjct: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
Query: 518 LELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPV 577
++ +V E+ SS +ES +++L
Sbjct: 464 AQV----------------QVGKQEEDSRSSSEESDSDREAL------------------ 489
Query: 578 ATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTG 631
++M+ A P G+ + K +G L PPG P P G
Sbjct: 490 ----AAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVG 539
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 58.5 bits (140), Expect = 2e-08
Identities = 142/678 (20%), Positives = 257/678 (37%), Gaps = 121/678 (17%)
Query: 242 CAPAAVA--TSPPGAIPKEACGGAPLQGLP-------GEALGCPAGVGTPVPADGTQTLT 292
C P++ +S A+ K G GLP E C V G++
Sbjct: 282 CKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAK 341
Query: 293 CAHTSAPESTAPTNHLVAGRAMTLS-PQEEVAAGQMASSSRSGPVKLEFDVSDGATSKR- 350
+ APE T + R P+++ +A + SS S +++ + + S
Sbjct: 342 ASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSI 401
Query: 351 APPPRRL-----GERSGLKP---------PLRKAAVRQQKAPQEVEEDDGRSGAGEDPPM 396
A P+ G RS + P+ A RQ + P +E+ D + ++
Sbjct: 402 ASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQS 461
Query: 397 PASRGSYHLDWDKMDDPNFIPFG----GDTKSGCSEAQPPESPE--------TRLGQPAA 444
S+G +++ P +P +S +E +PP+ PE LG+ +A
Sbjct: 462 KQSKGLE----ERLSPP--LPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSA 515
Query: 445 E------QLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSL 498
L A P C + + AE+ Q AE P +E+ S + +
Sbjct: 516 ASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDP----EEKVAVSPTPPV 571
Query: 499 PTSCPGSEPV-PTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQ 557
+EPV P Q + AL+ EE+ A+VL E D + K LR++
Sbjct: 572 SPEVRSTEPVAPPEQLSEAALKAMEEAV---AQVL----EQDQRHLLESKQEKMQQLREK 624
Query: 558 SLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKLVEFDFLGA-LDIPVPGP 616
+ + +LR + +++ + A E R RE + +L A +
Sbjct: 625 LCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD 684
Query: 617 PPGVPAPGGPPLS------------------------TGPIVDLLQYSQKDLDAVVKATQ 652
+ A L + + ++ S+K A + A +
Sbjct: 685 EDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK 744
Query: 653 E------------ENRELRSRCEELHGKNLE--LGKIMDRFEEVVYQAMEEVQKQKELSK 698
E E +E + E+ H LE + + EVV +++Q+ ++ +
Sbjct: 745 EKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEE 804
Query: 699 AEIQKVLKEKD----QLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYL 754
A++QK L + + Q + + E S L + EK++EV EG ++E L K E++
Sbjct: 805 AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR--EKRQEV-EG--EHERRLDKMKEEHQ 859
Query: 755 ARITQEGQRYQA--LKAHAE---------EKLQLANE-EIAQVRSKAQAEALALQASLRK 802
+ + ++Y+A K AE E+LQ A+E E+ VR + L+ R+
Sbjct: 860 QVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHRE 919
Query: 803 EQMRIQSLEKTVEQKTKE 820
++ ++Q LE +E + K+
Sbjct: 920 QERKLQDLELDLETRAKD 937
Score = 40.8 bits (94), Expect = 0.005
Identities = 45/216 (20%), Positives = 97/216 (44%), Gaps = 10/216 (4%)
Query: 629 STGPIVDLLQYSQKDL----DAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVY 684
ST P+ Q S+ L +AV + +++ R L +E + E K+ EE +
Sbjct: 577 STEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLRE--KLCQEEEEEIL 634
Query: 685 QAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEE 744
+ ++ ++ + +QK ++E++ + S S+ + Q + + + E
Sbjct: 635 RLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEA 694
Query: 745 SLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLR--K 802
SL+K E+ ++ Q+ +R + + + QL E A +S+ A A + +L+ +
Sbjct: 695 SLQKLREELESQ--QKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLR 752
Query: 803 EQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
EQ+ + E + + + EL R+C L +K ++
Sbjct: 753 EQLEGERKEAVATLEKEHSAELERLCSSLEAKHREV 788
Score = 37.7 bits (86), Expect = 0.045
Identities = 32/161 (19%), Positives = 75/161 (46%), Gaps = 10/161 (6%)
Query: 630 TGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE 689
TG + L + +++L+ V + + +LR R E K +L ++ + V +
Sbjct: 885 TGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLAL 944
Query: 690 VQKQKELSKAEIQKVLKEKDQLT----------TDLNSMEKSFSDLFKRFEKQKEVIEGY 739
++ Q+E ++ E Q++L + Q+ L +K + L + ++ +E+++
Sbjct: 945 LEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDEL 1004
Query: 740 RKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANE 780
+ + L+ V+ A+ Q + + +L+A A++K L E
Sbjct: 1005 QARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
Score = 34.7 bits (78), Expect = 0.38
Identities = 38/189 (20%), Positives = 82/189 (43%), Gaps = 13/189 (6%)
Query: 647 VVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLK 706
+ KA ++ E R + EL G L ++R + + +E V++++ ++++ +
Sbjct: 862 MAKAREQYEAEERKQRAELLG---HLTGELERLQRAHERELETVRQEQHKRLEDLRRRHR 918
Query: 707 EKDQLTTDLN-SMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQ 765
E+++ DL +E D+ R + E R+ ++ L + + +Q
Sbjct: 919 EQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
Query: 766 ALKAHAEEKLQL--ANEEIAQVRSKAQAEALAL-------QASLRKEQMRIQSLEKTVEQ 816
L+ +E L +N+++ ++ + QA L L QA ++ Q SLE ++
Sbjct: 979 QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
Query: 817 KTKENEELT 825
K E+T
Sbjct: 1039 KQHLLREVT 1047
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 57.4 bits (137), Expect = 5e-08
Identities = 47/197 (23%), Positives = 99/197 (50%), Gaps = 6/197 (3%)
Query: 648 VKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKE 707
++ +E+ +E + E K E + M R EE++++ E++++Q+E+ + +K+ ++
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 368
Query: 708 KDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNE---ESLKKCVEDYLARITQEGQRY 764
++ + M + ++++ EK +E+ E + E E +K E+ R ++ Q
Sbjct: 369 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428
Query: 765 QALKAHAEEKLQLANEEIAQVRSK--AQAEALALQASLRKEQMRIQSLEK-TVEQKTKEN 821
+A EEK++ E+I + K Q E + Q +R+E+ R + E E+K E
Sbjct: 429 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ 488
Query: 822 EELTRICDDLISKMEKI 838
EE+ R + + + EKI
Sbjct: 489 EEIWRQKEKMHEQEEKI 505
Score = 46.2 bits (108), Expect = 1e-04
Identities = 34/167 (20%), Positives = 85/167 (50%), Gaps = 9/167 (5%)
Query: 680 EEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGY 739
+E +++ E++ +Q+E + + +KV ++++++ + + ++++ EK +E E +
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547
Query: 740 RKNE---ESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALAL 796
R+ E E K E+ + R + EEK+ E+I + K Q + +
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM 607
Query: 797 ---QASLRKEQMRIQSLEKTV---EQKTKENEELTRICDDLISKMEK 837
+ +R+++ +IQ E+ + E+K +E EE+T+ ++ + + E+
Sbjct: 608 WKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 654
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/215 (23%), Positives = 101/215 (46%), Gaps = 30/215 (13%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKEL 696
L YSQ VK + E R+L SR + +F + QA+ V QK+
Sbjct: 146 LYYSQH----AVKQLEGEARDLISRLHDSW-----------KFAGELEQALSAVATQKKK 190
Query: 697 SKAEIQKVLKEKDQLTTDL---NSMEKSFSDLFKRFEKQKEVIEGYRK----NEESLKKC 749
+ I+++ KE+D L+ +L ++ + + +++ +++E + N + LK+
Sbjct: 191 ADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRK 250
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEI-AQVRSKAQAEALALQ--ASLRKEQMR 806
+E A++ Q+ QA H ++LQ + ++ AQV L Q + +++ +
Sbjct: 251 LE--RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 807 IQSLEKTV---EQKTKENEELTRICDDLISKMEKI 838
IQ E+ + E+K +E EE R ++ + + E++
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343
Score = 40.4 bits (93), Expect = 0.007
Identities = 43/222 (19%), Positives = 100/222 (45%), Gaps = 18/222 (8%)
Query: 634 VDLLQYSQKDLDAVVKATQE--ENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQ 691
+ L++ + ++ VK + E +L ++L + LGK + + +EE +
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE 289
Query: 692 KQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESL----- 746
L++ + +K+ ++++++ +++ + ++ EK +E E R+ EE +
Sbjct: 290 LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 747 -KKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKA--------QAEALALQ 797
+ E+ + ++ +R + + EEK++ E + + K + E + Q
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 409
Query: 798 ASLRKEQMRIQSLEKTVEQKTK--ENEELTRICDDLISKMEK 837
R+E+ +I+ EK EQ+ K EE R ++ I + EK
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 451
Score = 30.8 bits (68), Expect = 5.5
Identities = 26/135 (19%), Positives = 66/135 (48%), Gaps = 6/135 (4%)
Query: 652 QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQL 711
+E+ RE + +E K E + + EE+ + E++ +Q+E + +K+ ++++ +
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 712 ---TTDLNSMEKSFSDLFKRFEKQKEVIEGYRKN--EESLKKCVEDYLARITQEGQRYQA 766
+ EK + ++ +Q+E+++ + E+ K C ++ + +E R Q
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 767 LKAHAEEKLQLANEE 781
K E++++L +E
Sbjct: 731 EKMW-EQEVRLRQQE 744
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.6 bits (135), Expect = 9e-08
Identities = 49/191 (25%), Positives = 101/191 (52%), Gaps = 18/191 (9%)
Query: 649 KATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEK 708
K ++ E S+ E K L KI ++ +EV+ +EE K++E ++ E++K ++
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNK-QEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 709 DQLTTDLN----SMEKSFSDLFKRFEKQKEVIEG--YRKNEESLK-----KCVEDYLARI 757
D TTDL ++ +L + K++E ++G R ++E+L K V + A+I
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 758 TQEGQRYQALKA---HAEEKLQLANEEIAQVRSKAQ--AEALALQASLR-KEQMRIQSLE 811
+ + +++ KA AE++ + +EE+ ++++ + + A Q LR K + + L+
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 812 KTVEQKTKENE 822
K +E++TK +E
Sbjct: 1181 KALEEETKNHE 1191
Score = 50.8 bits (120), Expect = 5e-06
Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 34/222 (15%)
Query: 637 LQYSQKDLDAVV---KATQEENRELRSRCE----ELHGKNLELGKIMDRFEEVVYQAMEE 689
L+ QK D ++ K+ E R R E E K L L + + E +A EE
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL----EEALEAKEE 1501
Query: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
++Q + +A+++ ++ KD + +++ +EKS L ++ E+ + +E + E+ L +
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE---ELEDEL-QA 1557
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEE--------IAQVR-------SKAQAEAL 794
ED R+ QA+KA E LQ +E+ I QVR + + AL
Sbjct: 1558 TEDAKLRLE---VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 795 ALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKME 836
A+ AS +K ++ ++ LE +E K +E+ + L ++M+
Sbjct: 1615 AV-ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Score = 43.9 bits (102), Expect = 6e-04
Identities = 43/212 (20%), Positives = 93/212 (43%), Gaps = 20/212 (9%)
Query: 642 KDLDAVVKATQEENRELRSRCEELHGKNLE-----------LGKIMDRFEEVVYQAMEEV 690
K L V ++ + ++L ++ +ELH K E K+ + + V E
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Query: 691 QKQKELSK--AEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKK 748
+K + +K A ++ L++ +L + + + S ++ E++K ++ ++ EE +K
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 749 CVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQ 808
+E + + + K ++ L E + + + K +A AL L ++ +
Sbjct: 1361 NLEKQVLALQSQ---LADTKKKVDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 809 SLEKTVEQKTKENEELTRICD---DLISKMEK 837
LEKT + +E ++LT D + S +EK
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEK 1448
Score = 43.1 bits (100), Expect = 0.001
Identities = 49/191 (25%), Positives = 85/191 (44%), Gaps = 23/191 (12%)
Query: 654 ENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEE---VQKQKELSKAEIQKV---LKE 707
E E+R+R L K EL +I+ E V + E +Q +K+ +A IQ + L E
Sbjct: 905 EAEEMRAR---LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 708 KDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQAL 767
++ L + + K+ E++ ++E KK +ED +A + +
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ------- 1014
Query: 768 KAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRI 827
A EEK + +A++R+K + L+ L+KE+ Q LEK K K + E T +
Sbjct: 1015 LAEEEEKAK----NLAKIRNKQEVMISDLEERLKKEEKTRQELEKA---KRKLDGETTDL 1067
Query: 828 CDDLISKMEKI 838
D + +I
Sbjct: 1068 QDQIAELQAQI 1078
Score = 41.6 bits (96), Expect = 0.003
Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 27/214 (12%)
Query: 641 QKDLDAVVKATQEENRE---LRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELS 697
+ L + QEE R+ L SR +L + L + + EE A + ++KQ
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE----ARKNLEKQVLAL 1369
Query: 698 KAEIQKVLKEKDQLTTDLNSMEKSFSDLFK-------RFEKQKEVIEGYRKNEESLKKCV 750
++++ K+ D + S+E++ L K R E++ + K + L++ +
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429
Query: 751 EDYLARITQEGQRYQALKAHAEEKLQLANEE------IAQVRSKAQAEALALQASLRKEQ 804
+D + + Q L+ ++ QL EE A+ R +A+AEA R+++
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA-------REKE 1482
Query: 805 MRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
+ SL + +E+ + EE R L + ME +
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 40.0 bits (92), Expect = 0.009
Identities = 38/186 (20%), Positives = 85/186 (45%), Gaps = 25/186 (13%)
Query: 656 RELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDL 715
R+L++R E+ K L K + E +E+ +KQ+ L+ A +K+ + L +
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEA----ELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 716 NSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKA------ 769
+ K+ ++ K+ K + ++ Y++ E + ++ A+ + ++ ++L+A
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 770 -----------HAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKT 818
HAE++ +E+A + + + AL R+ + RI LE+ +E++
Sbjct: 1694 EELASSERARRHAEQE----RDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 819 KENEEL 824
E L
Sbjct: 1750 SNMELL 1755
Score = 39.3 bits (90), Expect = 0.015
Identities = 49/233 (21%), Positives = 95/233 (40%), Gaps = 31/233 (13%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELH----GKNLEL-GKIMDRFEEVVYQ------ 685
L+ +++ LD Q++ EL+++ +EL K EL G + +E +++
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112
Query: 686 ------AMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGY 739
+ E+Q+ E KA K K+K L+ +L +++ D Q+E+
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 740 RKNEESLKKCVED----YLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQ----- 790
+ LKK +E+ + A+I QR+ E+L+ A A + Q
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 791 -----AEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
E LQ + + + + L+ V++ + E R+ +L K K+
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL 1285
Score = 38.1 bits (87), Expect = 0.034
Identities = 38/200 (19%), Positives = 90/200 (45%), Gaps = 7/200 (3%)
Query: 642 KDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEI 701
+++ A + A ++E E+ E + E +I+ ++ + ++++++Q + +
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 702 QKVLKEKDQLTTDLNSMEKS---FSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARIT 758
QK+ EK + ME+ D +F K+K+++E S E+ +
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 759 QEGQRYQALKAHAEEKL---QLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVE 815
+ + + + + EE+L + +E+ + + K E LQ + + Q +I L+ +
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 816 QKTKENE-ELTRICDDLISK 834
+K +E + L R D+ + K
Sbjct: 1087 KKEEELQGALARGDDETLHK 1106
Score = 37.4 bits (85), Expect = 0.058
Identities = 41/199 (20%), Positives = 90/199 (45%), Gaps = 17/199 (8%)
Query: 649 KATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEK 708
KA E+N++ L N EL + ++V ++ E +K+ + E+ + E
Sbjct: 1219 KANLEKNKQ------GLETDNKELACEVKVLQQVKAES-EHKRKKLDAQVQELHAKVSEG 1271
Query: 709 DQLTTDL----NSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRY 764
D+L +L + ++ ++ E+ ++ + K+ SL+ ++D + +E ++
Sbjct: 1272 DRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 765 QALKAHA----EEK--LQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKT 818
L + EEK LQ EE + R + + LALQ+ L + ++ T+E
Sbjct: 1332 LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE 1391
Query: 819 KENEELTRICDDLISKMEK 837
+ ++L + + L ++E+
Sbjct: 1392 EAKKKLLKDAEALSQRLEE 1410
Score = 35.0 bits (79), Expect = 0.29
Identities = 29/152 (19%), Positives = 70/152 (46%), Gaps = 13/152 (8%)
Query: 652 QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQL 711
+ +N+EL+++ +EL G + +F+ + ++ + +E ++++ KE+
Sbjct: 1791 ERQNKELKAKLQELE------GAVKSKFKATISALEAKIGQLEE----QLEQEAKERAAA 1840
Query: 712 TTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHA 771
+ EK ++F + E ++ + Y++ E ++ L R +E + +A +A+A
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ-LKRQLEEAEE-EATRANA 1898
Query: 772 -EEKLQLANEEIAQVRSKAQAEALALQASLRK 802
KLQ ++ + E L+ LR+
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
>gi|22749429 coiled-coil domain containing 89 [Homo sapiens]
Length = 374
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/191 (24%), Positives = 90/191 (47%), Gaps = 12/191 (6%)
Query: 657 ELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLN 716
+L RCE L G EL + +R + QA ++ EL + KE +QL + L
Sbjct: 178 QLTVRCEALTG---ELETLKERCAQDACQAQAREKELLELQSQQACTHTKETEQLRSQLQ 234
Query: 717 SMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCV----EDYLARITQEG---QRYQALKA 769
++++ ++ K +E + ++ + V E+ L + G Q QA
Sbjct: 235 TLKQQHQQAVEQIAKAEETHSSLSQELQARLQTVTREKEELLQLSIERGKVLQNKQAEIC 294
Query: 770 HAEEKLQLANEEIAQVRSKAQAEALALQASL--RKEQMRIQSLEKTVEQKTKENEELTRI 827
EEKL++ANE+ + + EA+A+ ++L R+ Q ++ ++K ++ ++E +
Sbjct: 295 QLEEKLEIANEDRKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDELRLQSEAFKKH 354
Query: 828 CDDLISKMEKI 838
DL+SK ++
Sbjct: 355 SLDLLSKEREL 365
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 55.5 bits (132), Expect = 2e-07
Identities = 88/412 (21%), Positives = 157/412 (38%), Gaps = 37/412 (8%)
Query: 133 SPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLD 192
SPA E A++ ++SP E + SP + ++ + S +
Sbjct: 526 SPAEAKSPEKEEAKSP-AEVKSPEKAKSPAKEEAK--SPPEAKSPEKEEAKSPAEVKSPE 582
Query: 193 RRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSPP 252
+ +PA E + P +S KA++P E + AE +EE + +PA V +
Sbjct: 583 KAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK-----SPAEVKSPEK 637
Query: 253 GAIP--KEACGGAPLQGLPGEALGCPAGVGTPVPADG-----TQTLTCAHTSAPE-STAP 304
P +EA + E P +PV A+ ++ A +PE + +P
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 305 TNHLVAGRAMTLSP-QEEVAAGQMASS----SRSGPVKLEFDVSDGATS-KRAPPPRRLG 358
SP +EE + + A S P K + V + A S ++A P +
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 359 ERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPF 418
P + A + ++P + + +S E+ P + L D IP
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP-EKAKSPLKEDAKAPEKEIPK 816
Query: 419 GGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLA 478
+ KS E + P+ + + AE+ A PAT + +++ + E+ P +
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-PATPK-----TEEKKDSKKEEAP--KKE 868
Query: 479 AETPTAESK-----ERALNSASTSLPTSCPGSEPVPTHQQGQPA-LELKEES 524
A P E K E+ S + + VPT ++ PA +E+KE++
Sbjct: 869 APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA 920
Score = 47.0 bits (110), Expect = 7e-05
Identities = 90/490 (18%), Positives = 170/490 (34%), Gaps = 45/490 (9%)
Query: 46 PKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQL 105
P+ L K V+ ++ + +++ S + E ++ T + + V ++E +
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKS---EKETVIVEEQTEETQVTEEVTEEEEKEA- 478
Query: 106 IKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSE 165
KE + K G G+ A G ++S P A+ S ++ +
Sbjct: 479 -KEEEGKEEEG-------------GEEEEAEGGEEETKSPP---AEEAASPEKEAKSPVK 521
Query: 166 NQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECK 225
+ SP + ++ + S ++ +PA E + P +S K E AE +
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
Query: 226 AETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPA 285
+ A+EE + A SP + +EA A + E PA V +P A
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSP---VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA 638
Query: 286 DGTQTLTCAHTSAPE-STAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSD 344
++ T +PE + +P SP V A + PVK E +
Sbjct: 639 ---KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP---VKAEAKSPEKAKSPVKAEAKSPE 692
Query: 345 GATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDP-------PMP 397
A ++P K P+++ A +KA V+E+ + P P
Sbjct: 693 KA---KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEK 749
Query: 398 ASRGSYHLDWDKMDDPNFIPFGGDTKSGC----SEAQPPESPETRLGQPAAEQLHAGPAT 453
A D P + +S +A+ P E + + A L
Sbjct: 750 AKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA 809
Query: 454 EEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEPVPTHQQ 513
E +++ S E+ ++ + P +++E + + E P +
Sbjct: 810 PEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA 869
Query: 514 GQPALELKEE 523
+P +E K+E
Sbjct: 870 PKPKVEEKKE 879
>gi|51317366 myosin XVIIIB [Homo sapiens]
Length = 2567
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/174 (25%), Positives = 81/174 (46%), Gaps = 1/174 (0%)
Query: 656 RELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDL 715
R+LR L L LG + D V + +E+V Q E S+A+ ++ LK + LT DL
Sbjct: 1802 RDLRRTHALLSDVQLLLGTMEDGKTSVSKEELEKVHSQLEQSEAKCEEALKTQKVLTADL 1861
Query: 716 NSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKL 775
SM ++ + E + + + L K +++ + + Q+++ L A + +
Sbjct: 1862 ESMHSELENMTRNKSLVDEQLYRLQFEKADLLKRIDEDQDDLNELMQKHKDLIAQSAADI 1921
Query: 776 QLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICD 829
E Q+ +A+ E LQ L+ QMRI+ LE++ + + + ICD
Sbjct: 1922 GQIQELQLQLE-EAKKEKHKLQEQLQVAQMRIEYLEQSTVDRAIVSRQEAVICD 1974
Score = 35.0 bits (79), Expect = 0.29
Identities = 37/204 (18%), Positives = 87/204 (42%), Gaps = 12/204 (5%)
Query: 643 DLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKEL------ 696
DL+++ + R E+L+ E ++ R +E E +QK K+L
Sbjct: 1860 DLESMHSELENMTRNKSLVDEQLYRLQFEKADLLKRIDEDQDDLNELMQKHKDLIAQSAA 1919
Query: 697 SKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFE--KQKEVIEGYRKNEESLKKCVEDYL 754
+IQ++ + ++ + + +++ R E +Q V +E++ +E+
Sbjct: 1920 DIGQIQELQLQLEEAKKEKHKLQEQLQVAQMRIEYLEQSTVDRAIVSRQEAVICDLENKT 1979
Query: 755 ARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTV 814
+ +R++ L + L EE++Q + + + S + Q R++ L+ +
Sbjct: 1980 EFQKVQIKRFEVLVIRLRDSLIKMGEELSQAATSESQQ----RESSQYYQRRLEELKADM 2035
Query: 815 EQKTKENEELTRICDDLISKMEKI 838
E+ + E +R C +L +E++
Sbjct: 2036 EELVQREAEASRRCMELEKYVEEL 2059
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 54.3 bits (129), Expect = 5e-07
Identities = 51/224 (22%), Positives = 107/224 (47%), Gaps = 29/224 (12%)
Query: 635 DLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQK 694
D++ Y QK +D+ + E +L KN EL + +D + + +A E+++ Q
Sbjct: 179 DIIDY-QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLT-EANEKIEVQN 236
Query: 695 ELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYR------------KN 742
+ + +++ ++E +++T + N M+ ++ K+ + Y+ KN
Sbjct: 237 QEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
Query: 743 EE------SLKKCVEDY---LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEA 793
EE ++ VE++ L+ E YQ + + EKL+ A + + +
Sbjct: 297 EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADK------SNV 350
Query: 794 LALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK 837
+ALQ +++ +I+ L + VEQ TKE E+ T I +DL +++++
Sbjct: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR 394
Score = 47.0 bits (110), Expect = 7e-05
Identities = 46/187 (24%), Positives = 82/187 (43%), Gaps = 18/187 (9%)
Query: 653 EENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKEL------SKAEIQKVLK 706
+ +EL+ +L +N+EL +++ + + + +V+ KE+ KAE+Q+ L
Sbjct: 2056 QREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
Query: 707 EKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC----VEDYLARITQEGQ 762
K+ +L K K+V+E ++ E LKK + +A I QE +
Sbjct: 2116 H----VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
Query: 763 RYQA----LKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKT 818
+ +A LKAH +L + E + K AE L+ L+KE + L
Sbjct: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
Query: 819 KENEELT 825
NE++T
Sbjct: 2232 ILNEKMT 2238
Score = 38.9 bits (89), Expect = 0.020
Identities = 47/193 (24%), Positives = 87/193 (45%), Gaps = 29/193 (15%)
Query: 638 QYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELS 697
Q + L +K +E N EL ++ EL NL+ K+ + + ++ K +S
Sbjct: 1077 QKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSV-----SKAVS 1131
Query: 698 KAEIQKVLK-EKDQLTTDLN-SMEKSFSDLFKRFEKQKEVIEGYR----KNEESLKKCVE 751
A+ Q++L+ EK+++ + S + SD+ +R Q E++ + K ESL+ +
Sbjct: 1132 DADRQRILELEKNEMELKVEVSKLREISDIARR---QVEILNAQQQSRDKEVESLRMQLL 1188
Query: 752 DYLARITQEGQRYQALKAHAEE-KLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSL 810
DY A Q ++ K H LQL ++A AL S+ + ++++
Sbjct: 1189 DYQA---QSDEKSLIAKLHQHNVSLQL-----------SEATALGKLESITSKLQKMEAY 1234
Query: 811 EKTVEQKTKENEE 823
+EQK E E+
Sbjct: 1235 NLRLEQKLDEKEQ 1247
Score = 38.5 bits (88), Expect = 0.026
Identities = 54/239 (22%), Positives = 107/239 (44%), Gaps = 37/239 (15%)
Query: 635 DLLQYSQKDLDAVVKATQEENRELRSRCEE--LHGKNLELGKIMDRFEEVVYQAMEEVQK 692
DL + + + ++ ++ E EL+S +E +H + + + +EV A+EEV+K
Sbjct: 17 DLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVEL-ALEEVEK 75
Query: 693 Q-KELSKAEIQ---KVLKEKDQLTT--------DLNSMEKSFSDLFKRFEKQKEVIEGYR 740
+E +K E Q KV+K +++L D + L K+ E++ +E
Sbjct: 76 AGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDME 135
Query: 741 KNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQ------VRSKAQAEAL 794
K E KK V + LA +E + + ++L+ NE++ Q + +Q E L
Sbjct: 136 KELEKEKK-VNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETL 194
Query: 795 A--------LQASLRKEQMR-------IQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
++ L K+ IQ+L + E+ +N+E+ + ++ + +MEK+
Sbjct: 195 LSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKM 253
Score = 36.6 bits (83), Expect = 0.099
Identities = 41/224 (18%), Positives = 109/224 (48%), Gaps = 35/224 (15%)
Query: 635 DLLQYSQKDLDAVVKATQE---ENRELRSRCEELHGKNLELGKIMDRFEEVVYQA---ME 688
+L+QY ++ + +A ++ +N+E+R EE + ++ +R + +V+Q ++
Sbjct: 214 ELIQYLD-EIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVID 272
Query: 689 EVQKQKELSKAEIQKVL-------KEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRK 741
+++K+ + + ++Q++ +E D + +N+ + + + K E+IE Y++
Sbjct: 273 QLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILS--SKDDEIIE-YQQ 329
Query: 742 NEESLKKCVEDYLARITQEGQRYQALKAHAEEK---LQLANEEIAQVRSKAQAEALALQ- 797
+L++ +++ A++ + AL+ +E+ +++ E++ Q + + ++
Sbjct: 330 MLHNLREKLKN--AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIED 387
Query: 798 ----------ASLRKEQ--MRIQSLEKTVEQKTKENEELTRICD 829
AS +Q M+IQS +++KTKE E + +
Sbjct: 388 LKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAE 431
Score = 35.4 bits (80), Expect = 0.22
Identities = 31/142 (21%), Positives = 64/142 (45%), Gaps = 12/142 (8%)
Query: 694 KELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLK---KCV 750
KE+ K + + ++++ L S+ K + K EKQ+ VI +R + +K + V
Sbjct: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKS-EKQENVIHLFRITQSLMKMKAQEV 66
Query: 751 EDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKA--------QAEALALQASLRK 802
E L + + G+ + + K+ E+ + A + E L+ L +
Sbjct: 67 ELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQ 126
Query: 803 EQMRIQSLEKTVEQKTKENEEL 824
+ ++ +EK +E++ K NE+L
Sbjct: 127 KDRELEDMEKELEKEKKVNEQL 148
Score = 35.0 bits (79), Expect = 0.29
Identities = 45/179 (25%), Positives = 72/179 (40%), Gaps = 27/179 (15%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
+DLL S K++ + +REL + +L + K ++ +E+V E KQ
Sbjct: 594 LDLL--SLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELV-----EENKQ 646
Query: 694 KELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDY 753
E EI + +KE Q D+ E S + E+ IE KN E +
Sbjct: 647 LEEGMKEILQAIKEM-QKDPDVKGGETSL--IIPSLERLVNAIES--KNAEGIFDASLHL 701
Query: 754 LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK 812
A++ Q R NEE+ Q +++ EA+ L K ++I LEK
Sbjct: 702 KAQVDQLTGR---------------NEELRQELRESRKEAINYSQQLAKANLKIDHLEK 745
Score = 33.1 bits (74), Expect = 1.1
Identities = 36/179 (20%), Positives = 80/179 (44%), Gaps = 13/179 (7%)
Query: 658 LRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKD------QL 711
+ S+ +++ NL L + +D E+ +Y A E + + + + IQ + ++ Q
Sbjct: 1224 ITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQ 1283
Query: 712 TTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNE------ESLKKCVEDYLARITQEGQRYQ 765
+M + +D K ++ K + +R E E K +E+ ++ + +
Sbjct: 1284 EKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQK 1343
Query: 766 ALKAHAE-EKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEE 823
+ H + E+L+L ++ + K + E L + + + I SLE+ + Q+ K +EE
Sbjct: 1344 VINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE 1402
Score = 32.3 bits (72), Expect = 1.9
Identities = 46/213 (21%), Positives = 92/213 (43%), Gaps = 25/213 (11%)
Query: 643 DLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQ 702
+L A + A EE + +E H L + +I+DR + +E++ + K ++
Sbjct: 1750 ELRAEMTAAAEERIISATSQKEAH---LNVQQIVDRHTRELKTQVEDLNENLLKLKEALK 1806
Query: 703 KVLKEKDQLTTDLNSMEKSFSDLFKRFEK---QKEVIEGYRKNEESLK-----------K 748
++ LT +LN + K + K +KE I+ ++N+E + K
Sbjct: 1807 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID--QENDELKRQIKRLTSGLQGK 1864
Query: 749 CVEDYLARITQEGQR-YQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRI 807
+ D + +E QR + L+ E K++ ++ ++ K E L +K Q +I
Sbjct: 1865 PLTDNKQSLIEELQRKVKKLENQLEGKVE--EVDLKPMKEKNAKEELIRWEEGKKWQAKI 1922
Query: 808 QSLEKTVEQKTKENEELTR---ICDDLISKMEK 837
+ + +++K E LT+ DL +K +K
Sbjct: 1923 EGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK 1955
Score = 30.0 bits (66), Expect = 9.3
Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 24/189 (12%)
Query: 659 RSRCEELHGKNLEL-GKIMDRFEEVVYQAMEEVQKQKELSKAE-----------IQKVLK 706
+S EEL K +L ++ + EEV + M+E ++EL + E I+ LK
Sbjct: 1871 QSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLK 1930
Query: 707 EKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQA 766
EK+ L + DLF + +K+K ++ + ++ V+ L E ++
Sbjct: 1931 EKEGEVFTLTKQLNTLKDLFAKADKEKLTLQ---RKLKTTGMTVDQVLGIRALESEK--E 1985
Query: 767 LKAHAEEKLQLANEEIAQVRSKA-----QAEALALQASLRKEQMRIQSLEKTVEQKTKEN 821
L+ + L L N+ + +A E L LQ R Q ++ +LEK + T
Sbjct: 1986 LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQN--RYLQEKLHALEKQFSKDTYSK 2043
Query: 822 EELTRICDD 830
++ I D
Sbjct: 2044 PSISGIESD 2052
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 52.8 bits (125), Expect = 1e-06
Identities = 39/199 (19%), Positives = 98/199 (49%), Gaps = 13/199 (6%)
Query: 636 LLQYSQKDLDAVVKATQEENRELRSRCEELHGKN---LELGKIMDRFEEVVYQAMEEVQK 692
L+Q + K+ + + A + EN L ++L K + +++ ++V+++ +++
Sbjct: 755 LIQVATKEEE--LNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+EL +AE+ KV ++ + + S + +L K E+Q ++ + +E
Sbjct: 813 VEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGK 872
Query: 753 YLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK 812
+L + +E ++LKAH +E +A + + S +Q E L+ L++++ ++ LE
Sbjct: 873 WLQDLQEEN---ESLKAHVQE---VAQHNLKEASSASQFE--ELEIVLKEKENELKRLEA 924
Query: 813 TVEQKTKENEELTRICDDL 831
++++ + T++ D+
Sbjct: 925 MLKERESDLSSKTQLLQDV 943
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/203 (20%), Positives = 87/203 (42%), Gaps = 8/203 (3%)
Query: 636 LLQYSQKDLDAVVK---ATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
+L+ +KDL K QEEN L++ +E+ NL+ +FEE +E V K
Sbjct: 859 VLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE-----LEIVLK 913
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+KE ++ +LKE++ + + + D K F+ Q E ++ + S E+
Sbjct: 914 EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE 973
Query: 753 YLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK 812
L I++ + L + + + + A++A E+M + K
Sbjct: 974 LLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNK 1033
Query: 813 TVEQKTKENEELTRICDDLISKM 835
T +++ ++ E + +++ K+
Sbjct: 1034 TSKERQQQVEAVELEAKEVLKKL 1056
Score = 35.0 bits (79), Expect = 0.29
Identities = 40/195 (20%), Positives = 84/195 (43%), Gaps = 7/195 (3%)
Query: 635 DLLQYSQKDLDAVVKATQEENRELRSRC--EELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
D + + K+ V+A + E +E+ + + NL G+ + FE+ + M
Sbjct: 1029 DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1088
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+E+ E + LKE D++ T L + + + E + ++ + EE+ K D
Sbjct: 1089 SEEVKVLEHK--LKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVD 1146
Query: 753 YLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK 812
+ ++ Q E+L+ N++I +R + + + L+ + E R + +
Sbjct: 1147 ESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE---KAEMERSTYVTE 1203
Query: 813 TVEQKTKENEELTRI 827
E K + NE LT++
Sbjct: 1204 VRELKAQLNETLTKL 1218
Score = 33.5 bits (75), Expect = 0.84
Identities = 31/154 (20%), Positives = 71/154 (46%), Gaps = 7/154 (4%)
Query: 685 QAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEE 744
+ ++++Q L KAE+QK+ ++ + +EK ++ + +K + ++E ++E
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR-LLEEQLQHEI 693
Query: 745 SLK----KCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASL 800
S K K + D + E Q+ Q L + K + E++ + + + ++ L
Sbjct: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV--EQMEKCIQEKDEKLKTVEELL 751
Query: 801 RKEQMRIQSLEKTVEQKTKENEELTRICDDLISK 834
+++ + E+ + EN LT+ DL +K
Sbjct: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK 785
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 52.8 bits (125), Expect = 1e-06
Identities = 45/191 (23%), Positives = 88/191 (46%), Gaps = 19/191 (9%)
Query: 640 SQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKA 699
SQ+DL + + L++ EEL LE +R ++ Q + + ++ +L
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRA-TLEQ---TERSRKIAEQELLDASERVQLLHT 1724
Query: 700 EIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQ 759
+ ++ K +L TD++ M+ D +++ R EE KK + D A + +
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMED----------ILQEARNAEEKAKKAITD-AAMMAE 1773
Query: 760 EGQRYQALKAHAEEKLQLANEEIAQVRSKA-QAEALALQA---SLRKEQMRIQSLEKTVE 815
E ++ Q AH E + + + ++ + +AE LAL+ ++K + R++ LE VE
Sbjct: 1774 ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1833
Query: 816 QKTKENEELTR 826
+ K N E +
Sbjct: 1834 SEQKRNAEAVK 1844
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/223 (22%), Positives = 100/223 (44%), Gaps = 30/223 (13%)
Query: 637 LQYSQKDLDAVVKATQEE---NRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQK 692
LQ K+L A ++ +EE R R++ E+ + EL +I +R EE +++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 693 QKELSKAEIQKVLKEKDQLT--------TDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEE 744
K+ +AE QK+ ++ ++ T T S ++L ++ + + V + K +
Sbjct: 1170 NKK-REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228
Query: 745 SLKKCVEDYLARI---------------TQEGQRYQALKAHAEEKLQLANEEIAQVRSKA 789
+K ++D + + T E Q LK+ EE+ +L N+ AQ R +
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQ-RGRL 1286
Query: 790 QAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLI 832
Q E+ L +++ + L + + T++ EEL R ++ I
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329
Score = 42.4 bits (98), Expect = 0.002
Identities = 44/218 (20%), Positives = 93/218 (42%), Gaps = 24/218 (11%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEE--------------LHGKNLELGKIMDRF 679
V+ + ++ +L+ + + +++ EL+S+ EE L ++ E + +D
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 680 EEVVYQAMEEVQ---KQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVI 736
E +V Q Q +Q E K ++++ +K K+ L L S L +++E+++E
Sbjct: 1301 EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE-- 1358
Query: 737 EGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALAL 796
++ L++ + + Q +Y+ E+L+ A +++AQ A+ A+
Sbjct: 1359 -----SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 797 QASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISK 834
A + Q L+ VE + E C L K
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Score = 41.2 bits (95), Expect = 0.004
Identities = 39/194 (20%), Positives = 90/194 (46%), Gaps = 19/194 (9%)
Query: 644 LDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQK 703
L+ + Q E +L E + L K F+++ + E +++ E + AE++
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI----LAEWKQKCEETHAELEA 1475
Query: 704 VLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQR 763
KE L T+L ++ + +E+ + +E ++ ++L++ + D +I + G+R
Sbjct: 1476 SQKEARSLGTELFKIKNA-------YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 764 YQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEE 823
H EK++ +++ Q + + QA +ASL E+ +I ++ + Q E +
Sbjct: 1529 -----IHELEKIK---KQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 824 LTRICDDLISKMEK 837
D+ I ++++
Sbjct: 1581 KIAEKDEEIDQLKR 1594
Score = 39.3 bits (90), Expect = 0.015
Identities = 48/201 (23%), Positives = 86/201 (42%), Gaps = 42/201 (20%)
Query: 671 ELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFE 730
E+ + + F+++ + + K+KEL + + +LKEK+ L + + + +D +R +
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVT-LLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 731 -----------KQKEVIEGYRKNEE-----------------SLKKCVEDY---LARITQ 759
K KEV E EE LKK ++D LA++ +
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972
Query: 760 EGQRYQALKAHAEEKLQLANEEIA---QVRSKAQAEALALQASLRKEQMRIQSLEKTVEQ 816
E K E K++ EE+A + +K E ALQ + ++ +Q+ E V
Sbjct: 973 E-------KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 817 KTKENEELTRICDDLISKMEK 837
TK +L + DDL +E+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQ 1046
Score = 38.9 bits (89), Expect = 0.020
Identities = 50/221 (22%), Positives = 97/221 (43%), Gaps = 44/221 (19%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
+D L+ + ++ AT+ + + L L +L K +E Q ++++Q +
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 694 KE----LSKAEI---QKV------LKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYR 740
++ L+KA+I Q+V L+++ +L DL E+ K +EG
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDL--------------ERAKRKLEGD- 1064
Query: 741 KNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSK---AQAEALALQ 797
K ++ + I E K +EKL+ EI+ ++SK QA + LQ
Sbjct: 1065 ------LKLAQESIMDIENE-------KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 798 ASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
+++ Q RI+ LE+ +E + + + DL ++E+I
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Score = 36.6 bits (83), Expect = 0.099
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 26/197 (13%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
+V LL+ + DL V+A E + RC++L ++L + +EV +A +E +
Sbjct: 883 MVTLLK-EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEI 938
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
EL+ A+ +K+ E +L D++ +E + + + EK+K E K
Sbjct: 939 NAELT-AKKRKLEDECSELKKDIDDLELTLA----KVEKEKHATENKVK----------- 982
Query: 753 YLARITQE--GQRYQALKAHAEEK-LQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
+T+E G K E+K LQ A+++ + + L + K + ++
Sbjct: 983 ---NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 810 LEKTVEQKTKENEELTR 826
LE ++EQ+ K +L R
Sbjct: 1040 LEGSLEQEKKLRMDLER 1056
Score = 30.4 bits (67), Expect = 7.1
Identities = 43/208 (20%), Positives = 93/208 (44%), Gaps = 31/208 (14%)
Query: 648 VKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKE 707
++ + EN+ L+ +L + E GK R E +E+++KQ E K E+Q L+E
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGK---RIHE-----LEKIKKQVEQEKCELQAALEE 1552
Query: 708 KD-----------QLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLAR 756
+ ++ +LN ++ S++ ++ ++ E I+ ++N + + ++ L
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVK---SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609
Query: 757 ITQEGQRYQALKAHAEEKLQLANEEIAQVR--SKAQAEALA----LQASLRKEQMRIQSL 810
+ LK E L NE Q+ ++ AEAL Q L+ Q+ +
Sbjct: 1610 EIRSRNDAIRLKKKMEGDL---NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDA 1666
Query: 811 EKTVEQKTKENEELTRICDDLISKMEKI 838
++ E ++ + R + L +++E++
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEEL 1694
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 52.8 bits (125), Expect = 1e-06
Identities = 45/191 (23%), Positives = 88/191 (46%), Gaps = 19/191 (9%)
Query: 640 SQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKA 699
SQ+DL + + L++ EEL LE +R ++ Q + + ++ +L
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRA-TLEQ---TERSRKIAEQELLDASERVQLLHT 1724
Query: 700 EIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQ 759
+ ++ K +L TD++ M+ D +++ R EE KK + D A + +
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMED----------ILQEARNAEEKAKKAITD-AAMMAE 1773
Query: 760 EGQRYQALKAHAEEKLQLANEEIAQVRSKA-QAEALALQA---SLRKEQMRIQSLEKTVE 815
E ++ Q AH E + + + ++ + +AE LAL+ ++K + R++ LE VE
Sbjct: 1774 ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1833
Query: 816 QKTKENEELTR 826
+ K N E +
Sbjct: 1834 SEQKRNAEAVK 1844
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/223 (22%), Positives = 100/223 (44%), Gaps = 30/223 (13%)
Query: 637 LQYSQKDLDAVVKATQEE---NRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQK 692
LQ K+L A ++ +EE R R++ E+ + EL +I +R EE +++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 693 QKELSKAEIQKVLKEKDQLT--------TDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEE 744
K+ +AE QK+ ++ ++ T T S ++L ++ + + V + K +
Sbjct: 1170 NKK-REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228
Query: 745 SLKKCVEDYLARI---------------TQEGQRYQALKAHAEEKLQLANEEIAQVRSKA 789
+K ++D + + T E Q LK+ EE+ +L N+ AQ R +
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ-LSELKSKEEEQQRLINDLTAQ-RGRL 1286
Query: 790 QAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLI 832
Q E+ L +++ + L + + T++ EEL R ++ I
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329
Score = 42.4 bits (98), Expect = 0.002
Identities = 44/218 (20%), Positives = 93/218 (42%), Gaps = 24/218 (11%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEE--------------LHGKNLELGKIMDRF 679
V+ + ++ +L+ + + +++ EL+S+ EE L ++ E + +D
Sbjct: 1241 VETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEK 1300
Query: 680 EEVVYQAMEEVQ---KQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVI 736
E +V Q Q +Q E K ++++ +K K+ L L S L +++E+++E
Sbjct: 1301 EALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE-- 1358
Query: 737 EGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALAL 796
++ L++ + + Q +Y+ E+L+ A +++AQ A+ A+
Sbjct: 1359 -----SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 797 QASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISK 834
A + Q L+ VE + E C L K
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK 1451
Score = 41.2 bits (95), Expect = 0.004
Identities = 39/194 (20%), Positives = 90/194 (46%), Gaps = 19/194 (9%)
Query: 644 LDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQK 703
L+ + Q E +L E + L K F+++ + E +++ E + AE++
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKI----LAEWKQKCEETHAELEA 1475
Query: 704 VLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQR 763
KE L T+L ++ + +E+ + +E ++ ++L++ + D +I + G+R
Sbjct: 1476 SQKEARSLGTELFKIKNA-------YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 764 YQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEE 823
H EK++ +++ Q + + QA +ASL E+ +I ++ + Q E +
Sbjct: 1529 -----IHELEKIK---KQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 824 LTRICDDLISKMEK 837
D+ I ++++
Sbjct: 1581 KIAEKDEEIDQLKR 1594
Score = 39.3 bits (90), Expect = 0.015
Identities = 48/201 (23%), Positives = 86/201 (42%), Gaps = 42/201 (20%)
Query: 671 ELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFE 730
E+ + + F+++ + + K+KEL + + +LKEK+ L + + + +D +R +
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVT-LLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 731 -----------KQKEVIEGYRKNEE-----------------SLKKCVEDY---LARITQ 759
K KEV E EE LKK ++D LA++ +
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972
Query: 760 EGQRYQALKAHAEEKLQLANEEIA---QVRSKAQAEALALQASLRKEQMRIQSLEKTVEQ 816
E K E K++ EE+A + +K E ALQ + ++ +Q+ E V
Sbjct: 973 E-------KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 817 KTKENEELTRICDDLISKMEK 837
TK +L + DDL +E+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQ 1046
Score = 38.9 bits (89), Expect = 0.020
Identities = 50/221 (22%), Positives = 97/221 (43%), Gaps = 44/221 (19%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
+D L+ + ++ AT+ + + L L +L K +E Q ++++Q +
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 694 KE----LSKAEI---QKV------LKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYR 740
++ L+KA+I Q+V L+++ +L DL E+ K +EG
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDL--------------ERAKRKLEGD- 1064
Query: 741 KNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSK---AQAEALALQ 797
K ++ + I E K +EKL+ EI+ ++SK QA + LQ
Sbjct: 1065 ------LKLAQESIMDIENE-------KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 798 ASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
+++ Q RI+ LE+ +E + + + DL ++E+I
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Score = 36.6 bits (83), Expect = 0.099
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 26/197 (13%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
+V LL+ + DL V+A E + RC++L ++L + +EV +A +E +
Sbjct: 883 MVTLLK-EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEI 938
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
EL+ A+ +K+ E +L D++ +E + + + EK+K E K
Sbjct: 939 NAELT-AKKRKLEDECSELKKDIDDLELTLA----KVEKEKHATENKVK----------- 982
Query: 753 YLARITQE--GQRYQALKAHAEEK-LQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
+T+E G K E+K LQ A+++ + + L + K + ++
Sbjct: 983 ---NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 810 LEKTVEQKTKENEELTR 826
LE ++EQ+ K +L R
Sbjct: 1040 LEGSLEQEKKLRMDLER 1056
Score = 30.4 bits (67), Expect = 7.1
Identities = 43/208 (20%), Positives = 93/208 (44%), Gaps = 31/208 (14%)
Query: 648 VKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKE 707
++ + EN+ L+ +L + E GK R E +E+++KQ E K E+Q L+E
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGK---RIHE-----LEKIKKQVEQEKCELQAALEE 1552
Query: 708 KD-----------QLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLAR 756
+ ++ +LN ++ S++ ++ ++ E I+ ++N + + ++ L
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVK---SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDA 1609
Query: 757 ITQEGQRYQALKAHAEEKLQLANEEIAQVR--SKAQAEALA----LQASLRKEQMRIQSL 810
+ LK E L NE Q+ ++ AEAL Q L+ Q+ +
Sbjct: 1610 EIRSRNDAIRLKKKMEGDL---NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDA 1666
Query: 811 EKTVEQKTKENEELTRICDDLISKMEKI 838
++ E ++ + R + L +++E++
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIEEL 1694
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 52.8 bits (125), Expect = 1e-06
Identities = 46/197 (23%), Positives = 94/197 (47%), Gaps = 26/197 (13%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
+V LLQ + DL V+A Q+ + RC++L ++L E V + E ++
Sbjct: 879 MVSLLQ-EKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQL-------EAKVKEMNERLED 930
Query: 693 QKELSK---AEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
++E++ A+ +K+ E +L D++ +E + + + EK+K E KN
Sbjct: 931 EEEMNAELTAKKRKLEDECSELKKDIDDLELTLA----KVEKEKHATENKVKNLTEEMAG 986
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
+++ +A++T+E + Q A + LQ+ +++ +L S K + ++
Sbjct: 987 LDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN-----------SLSKSKVKLEQQVDD 1035
Query: 810 LEKTVEQKTKENEELTR 826
LE ++EQ+ K +L R
Sbjct: 1036 LEGSLEQEKKVRMDLER 1052
Score = 44.7 bits (104), Expect = 4e-04
Identities = 44/224 (19%), Positives = 96/224 (42%), Gaps = 32/224 (14%)
Query: 643 DLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQ 702
+L V + ++E E + +++ ++ K E+V + +E+ + + E Q
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS-RTLEDQANEYRVKLEEAQ 1269
Query: 703 KVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQ 762
+ L + TT ++ +L ++ E+++ +I + + S + +ED ++ +EG+
Sbjct: 1270 RSLND---FTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Query: 763 RYQAL------------------------KAHAEEKLQLANEEIAQVRSKAQAEAL---- 794
AL KA + L AN E+AQ R+K + +A+
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386
Query: 795 ALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
L+ + +K R+Q E+ VE + L + L +++E +
Sbjct: 1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430
Score = 43.9 bits (102), Expect = 6e-04
Identities = 51/210 (24%), Positives = 97/210 (46%), Gaps = 27/210 (12%)
Query: 637 LQYSQKDLDAVVKATQE-----ENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQ 691
L+ +++ L+ +K TQE EN +L+ E+L K ++ + + E+ A++ +
Sbjct: 1050 LERAKRKLEGDLKLTQESIMDLENDKLQLE-EKLKKKEFDINQQNSKIEDEQVLALQLQK 1108
Query: 692 KQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIE---GYRKNEESLKK 748
K KE ++A I+++ +E + T +EK SDL + E+ E +E G + + K
Sbjct: 1109 KLKE-NQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1167
Query: 749 CVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQ 808
+ +Q ++ EE L +E A K A+++A +I
Sbjct: 1168 ----------KREAEFQKMRRDLEE-ATLQHEATAAALRKKHADSVAELGE------QID 1210
Query: 809 SLEKTVEQKTKENEELTRICDDLISKMEKI 838
+L++ ++ KE E DD+ S ME+I
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240
Score = 43.1 bits (100), Expect = 0.001
Identities = 44/211 (20%), Positives = 97/211 (45%), Gaps = 26/211 (12%)
Query: 635 DLLQYSQKDLDAVVKATQEENR-------ELRSRCEELHGKNLEL-------GKIMDRFE 680
+LLQ ++L AVV+ T+ + E R + LH +N L + + +
Sbjct: 1681 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740
Query: 681 EVVYQAMEEVQKQKELSKAEI-------QKVLKEKD---QLTTDLNSMEKSFSDLFKRFE 730
V +A++E + +E +K I +++ KE+D L +ME++ DL R +
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1800
Query: 731 KQKEV-IEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKA 789
+ +++ ++G +K + L+ V + + E Q+ A K + +E+ +
Sbjct: 1801 EAEQIALKGGKKQLQKLEARVRELEGELEAE-QKRNAESVKGMRKSERRIKELTYQTEED 1859
Query: 790 QAEALALQASLRKEQMRIQSLEKTVEQKTKE 820
+ L LQ + K Q+++++ ++ E+ ++
Sbjct: 1860 KKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1890
Score = 42.7 bits (99), Expect = 0.001
Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 28/196 (14%)
Query: 637 LQYSQKDLDAVV----KATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
L Q++ D ++ + +E EL S +E + EL K+ + +EE + +
Sbjct: 1444 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL--------E 1495
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFK-RFEKQKEVIEGYRKNEESLKKCVE 751
E K E + + +E LT L K+ +L K R + + E +E EE+ + +E
Sbjct: 1496 HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEA-EASLE 1554
Query: 752 DYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLE 811
+I + + +KA E KL +EE+ Q + R Q + SL+
Sbjct: 1555 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK--------------RNHQRVVDSLQ 1600
Query: 812 KTVEQKTKENEELTRI 827
+++ +T+ E+ R+
Sbjct: 1601 TSLDAETRSRNEVLRV 1616
Score = 38.9 bits (89), Expect = 0.020
Identities = 50/201 (24%), Positives = 87/201 (43%), Gaps = 30/201 (14%)
Query: 648 VKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAE--IQKVL 705
+K T E++ R EE K++ +E ++ +Q L+ AE +++
Sbjct: 861 IKETLEKSEARRKELEE---------KMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLI 911
Query: 706 KEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEES---LKKCVEDY---LARITQ 759
K K QL + M + D E E+ RK E+ LKK ++D LA++ +
Sbjct: 912 KNKIQLEAKVKEMNERLED---EEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 968
Query: 760 EGQRYQALKAHAEEKLQLANEEIA---QVRSKAQAEALALQASLRKEQMRIQSLEKTVEQ 816
E K E K++ EE+A ++ +K E ALQ + ++ +Q E V
Sbjct: 969 E-------KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 817 KTKENEELTRICDDLISKMEK 837
+K +L + DDL +E+
Sbjct: 1022 LSKSKVKLEQQVDDLEGSLEQ 1042
Score = 37.0 bits (84), Expect = 0.076
Identities = 40/200 (20%), Positives = 87/200 (43%), Gaps = 17/200 (8%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQKQKE 695
LQ ++ D D +++ EE E ++ + + K N E+ + ++E Q EE+++ K+
Sbjct: 1335 LQSARHDCD-LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK 1393
Query: 696 LSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLA 755
+Q + + + +S+EK+ L E +E R N + A
Sbjct: 1394 KLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE--RSNAAA---------A 1442
Query: 756 RITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVE 815
+ ++ + + + A ++K + + E+ +Q EA +L L K + + + +E
Sbjct: 1443 ALDKKQRNFDKILAEWKQKYEESQSEL----ESSQKEARSLSTELFKLKNAYEESLEHLE 1498
Query: 816 QKTKENEELTRICDDLISKM 835
+EN+ L DL ++
Sbjct: 1499 TFKRENKNLQEEISDLTEQL 1518
Score = 35.8 bits (81), Expect = 0.17
Identities = 54/219 (24%), Positives = 91/219 (41%), Gaps = 40/219 (18%)
Query: 643 DLDAVVKATQEENRELRSRCEELHGK-NLELGKIM------DRFEEVVYQAMEEVQKQKE 695
+L+ V K + E EL+S EE E GKI+ ++ + + + + E ++ E
Sbjct: 1527 ELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1586
Query: 696 LSKAEIQK------------------VLKEKDQLTTDLNSMEKSFSDLFK-RFEKQKEVI 736
+K Q+ VL+ K ++ DLN ME S + E QK+V
Sbjct: 1587 QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV- 1645
Query: 737 EGYRKNEESLKKCVE---DYLARITQEGQRYQALKAHAEEKLQLANEEIAQV-----RSK 788
K+ +SL K + D R + + A+ LQ EE+ V RS+
Sbjct: 1646 ----KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701
Query: 789 AQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRI 827
AE ++ S R + + Q+ + QK K +LT++
Sbjct: 1702 KLAEQELIETSERVQLLHSQN-TSLINQKKKMESDLTQL 1739
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/216 (20%), Positives = 102/216 (47%), Gaps = 29/216 (13%)
Query: 645 DAVVKATQEEN------RELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEV---QKQKE 695
D++ K+ +N +EL + E L + E + +++ + V +A +E+ +K+ +
Sbjct: 930 DSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 696 LSKAEIQKVLKEKDQLTTDLNSM---EKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
K E++ + EKDQL+ + + +S+ +L +EKQ E ++ ++ + + +ED
Sbjct: 990 TVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIED 1049
Query: 753 YLARITQEGQRYQALKAHAEEKL----------QLANEEIAQV-RSKA------QAEALA 795
++ + + + + E+ L +L +I +V R+KA +AE L
Sbjct: 1050 LTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQ 1109
Query: 796 LQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDL 831
+ +++ + LE+ Q KE ++L + +L
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQEL 1145
Score = 38.9 bits (89), Expect = 0.020
Identities = 43/187 (22%), Positives = 94/187 (50%), Gaps = 21/187 (11%)
Query: 652 QEENRELRS---RCEELHGKNLELGKIMDRFE---EVVYQAMEEVQKQK-----ELSKAE 700
++ R+LR+ +CE ++ N +L ++ + +++ + EVQ+ K EL +
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEK 1107
Query: 701 IQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQE 760
+QK K K+ TT +N +E +L + +K+K+ ++ + E +KK + + E
Sbjct: 1108 LQKEQKIKEHATT-VNELE----ELQVQLQKEKKQLQKTMQELELVKKDAQQ-TTLMNME 1161
Query: 761 GQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKE 820
Y+ L +KL N +I + + + + Q +L++E I SL+ +V+Q ++
Sbjct: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQK-QKQETLQEE---ITSLQSSVQQYEEK 1217
Query: 821 NEELTRI 827
N ++ ++
Sbjct: 1218 NTKIKQL 1224
Score = 38.1 bits (87), Expect = 0.034
Identities = 56/231 (24%), Positives = 93/231 (40%), Gaps = 33/231 (14%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
++ L + D +K + EE +CE LELGK + E+ + E QK
Sbjct: 589 INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGK---KVEQTIQYNSELEQKV 645
Query: 694 KELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFE----KQKEVIEGYRKNEESLKKC 749
EL+ +++ LKEKDQ L + L + E + K + E K K+
Sbjct: 646 NELT-GGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQL 704
Query: 750 VEDYLARITQEGQRYQALKAH---AEEKLQLANEE---IAQVRSKAQAEALALQASL--- 800
D ++Q+ LK H E+KLQL EE + ++ Q + L ++ L
Sbjct: 705 SRDLEVFLSQKED--VILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF 762
Query: 801 -----------RKEQMRIQSLEKTVEQKTKENEELTRIC---DDLISKMEK 837
+E+ + L+ E K NEE + D+ + ++EK
Sbjct: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEK 813
Score = 37.7 bits (86), Expect = 0.045
Identities = 53/202 (26%), Positives = 91/202 (45%), Gaps = 21/202 (10%)
Query: 644 LDAVVKATQEENRELRSRCEELHGKNLELGK-IMDRFEEVVYQAME------EVQKQKEL 696
L AV ++ + N E + + K LEL K I EE V Q E + +++K L
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL 842
Query: 697 SKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLAR 756
+ E++++ EK+ L +DL M+ + R E Q +I+ EE + C + +
Sbjct: 843 LRKELEEIQSEKEALQSDLLEMKNANEK--TRLENQNLLIQ----VEEVSQTCSK---SE 893
Query: 757 ITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQ 816
I E ++ +K H K L +E+ R AE + L+ SL K +V++
Sbjct: 894 IHNEKEKC-FIKEHENLKPLLEQKELRDRR----AELILLKDSLAKSPSVKNDPLSSVKE 948
Query: 817 KTKENEELTRICDDLISKMEKI 838
++ E L + C + K+ KI
Sbjct: 949 LEEKIENLEKECKEKEEKINKI 970
Score = 37.4 bits (85), Expect = 0.058
Identities = 34/165 (20%), Positives = 72/165 (43%), Gaps = 9/165 (5%)
Query: 673 GKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQ 732
GKI FE + Q +V + ++ +++ EKD L +N ++ L Q
Sbjct: 499 GKISQEFESMKQQQASDVHELQQ----KLRTAFTEKDALLETVNRLQGENEKLLS----Q 550
Query: 733 KEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAE 792
+E++ ++L++ YL ++Q + L+ + ++ I ++++ + E
Sbjct: 551 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE-E 609
Query: 793 ALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK 837
+E+ I L K VEQ + N EL + ++L +E+
Sbjct: 610 MDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEE 654
Score = 36.6 bits (83), Expect = 0.099
Identities = 47/206 (22%), Positives = 89/206 (43%), Gaps = 40/206 (19%)
Query: 618 PGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMD 677
P P G L T P DL+++++K + + KA +SRC EL +
Sbjct: 12 PATPGTGKSKLETLPKEDLIKFAKKQMMLIQKA--------KSRCTELEKE--------- 54
Query: 678 RFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIE 737
EE+ + + E +I K L E+ L+++ L ++ E +++ +
Sbjct: 55 -IEELRSKPVTE-------GTGDIIKALTER------LDAL------LLEKAETEQQCLS 94
Query: 738 GYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQ 797
+K +K+ VED + ++ + + + ++++ E+ VRSK + LQ
Sbjct: 95 -LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQ 153
Query: 798 ASLRKEQMRIQSLEKTVEQKTKENEE 823
L +E M Q LE + + K + N E
Sbjct: 154 KQL-EEAMNTQ-LELSEQLKFQNNSE 177
Score = 35.8 bits (81), Expect = 0.17
Identities = 49/207 (23%), Positives = 96/207 (46%), Gaps = 17/207 (8%)
Query: 643 DLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQ---KQKELSKA 699
+L V+ T + N EL + EL G E K D+ ++ + + M +++ + KE+ A
Sbjct: 626 ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
Query: 700 EIQ-------KVLKEKDQLTTDLNSMEKSFSD--LFKRFEKQKEVIEGYRKNEESLKKCV 750
E++ K+ EK QL+ DL D L + + ++ ++ + +++L K +
Sbjct: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745
Query: 751 E-DYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
E + + ++ + Q Y LK E + + E+ +A E+LA + + K + Q
Sbjct: 746 ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLA-KINEEKCNLAFQR 804
Query: 810 LEKTVEQKTK---ENEELTRICDDLIS 833
EK +E + + EE C++L S
Sbjct: 805 DEKVLELEKEIKCLQEESVVQCEELKS 831
Score = 31.6 bits (70), Expect = 3.2
Identities = 47/208 (22%), Positives = 89/208 (42%), Gaps = 19/208 (9%)
Query: 639 YSQKDLDAVVKATQEENRELRSRCE---ELHGKNL-----ELGKIMDRFEEVVYQAMEEV 690
Y QK LDA +E +L++ E + + KN+ EL ++ +E V + M ++
Sbjct: 200 YLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQI 259
Query: 691 QKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCV 750
+ + +AEI K+ + K+ L + EK+ K++E + E + N +
Sbjct: 260 EASAKEHEAEINKLNELKENLVKQCEASEKNIQ---KKYECELENLRKATSNANQDNQIC 316
Query: 751 EDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSL 810
L T Q H E+ L +E+ S + E + K +M Q +
Sbjct: 317 SILLQENTFVEQVVNEKVKHLEDTL----KELESQHSILKDEVTYMNNLKLKLEMDAQHI 372
Query: 811 EKTVEQKTKENEELT-RICDDLISKMEK 837
+ ++ E E+L +I + L++K E+
Sbjct: 373 K---DEFFHEREDLEFKINELLLAKEEQ 397
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 52.0 bits (123), Expect = 2e-06
Identities = 48/197 (24%), Positives = 94/197 (47%), Gaps = 26/197 (13%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
+V LLQ + DL V+A Q+ + RC++L ++L E V + E ++
Sbjct: 877 MVSLLQ-EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQL-------EAKVKEMNERLED 928
Query: 693 QKELSK---AEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
++E++ A+ +K+ E +L D++ +E + + + EK+K E KN
Sbjct: 929 EEEMNAELTAKKRKLEDECSELKRDIDDLELTLA----KVEKEKHATENKVKNLTEEMAG 984
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
+++ +A++T+E + Q A + LQ A E+ +KA+ K + ++
Sbjct: 985 LDEIIAKLTKEKKALQEAHQQALDDLQ-AEEDKVNTLTKAKV----------KLEQQVDD 1033
Query: 810 LEKTVEQKTKENEELTR 826
LE ++EQ+ K +L R
Sbjct: 1034 LEGSLEQEKKVRMDLER 1050
Score = 44.7 bits (104), Expect = 4e-04
Identities = 52/206 (25%), Positives = 94/206 (45%), Gaps = 19/206 (9%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRC----EELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
L+ +++ L+ +K TQE +L + E L K+ EL + R E+ + +K
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKK 1107
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
KEL +A I+++ +E + T +EK SDL + E+ E +E E V+
Sbjct: 1108 LKEL-QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE-----EAGGATSVQI 1161
Query: 753 YLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK 812
+ + + +Q ++ EE L +E A K A+++A +I +L++
Sbjct: 1162 EMNK--KREAEFQKMRRDLEEAT-LQHEATAAALRKKHADSVAELGE------QIDNLQR 1212
Query: 813 TVEQKTKENEELTRICDDLISKMEKI 838
++ KE E DD+ S ME+I
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQI 1238
Score = 42.4 bits (98), Expect = 0.002
Identities = 52/237 (21%), Positives = 100/237 (42%), Gaps = 45/237 (18%)
Query: 636 LLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKE 695
LL+ +Q LD V+A N +L+ + +N L ++ VV E+ ++ ++
Sbjct: 1649 LLKDTQIQLDDAVRA----NDDLKENIAIVERRNNLLQAELEELRAVV----EQTERSRK 1700
Query: 696 LSKAEI----QKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVE 751
L++ E+ ++V Q T+ +N +K +DL + + +E ++ R EE KK +
Sbjct: 1701 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1760
Query: 752 DYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKA-QAEALALQAS----------- 799
D A + +E ++ Q AH E + + I ++ + +AE +AL+
Sbjct: 1761 D-AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1819
Query: 800 --------------------LRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKME 836
+RK + RI+ L E+ K L + D L K++
Sbjct: 1820 RELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK 1876
Score = 41.2 bits (95), Expect = 0.004
Identities = 53/217 (24%), Positives = 100/217 (46%), Gaps = 24/217 (11%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELG-KIMDRFEEVVYQAMEEVQ 691
I LL+ ++++ + + + +EE L+ E+ + EL K++ +E ++
Sbjct: 836 IKPLLKSAEREKE--MASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 692 KQKELSKAE--IQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEES---L 746
+Q L+ AE +++K K QL + M + D E E+ RK E+ L
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLED---EEEMNAELTAKKRKLEDECSEL 950
Query: 747 KKCVEDY---LARITQEGQRYQALKAHAEEKLQLANEEIA---QVRSKAQAEALALQASL 800
K+ ++D LA++ +E K E K++ EE+A ++ +K E ALQ +
Sbjct: 951 KRDIDDLELTLAKVEKE-------KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 801 RKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK 837
++ +Q+ E V TK +L + DDL +E+
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQ 1040
Score = 40.0 bits (92), Expect = 0.009
Identities = 47/215 (21%), Positives = 93/215 (43%), Gaps = 26/215 (12%)
Query: 637 LQYSQKDLDAVVKATQEE---NRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQK 692
LQ K+L A ++ +EE R R++ E+L + EL +I +R EE +++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNS----MEKSFSDLFKRFEKQKEVIEGYRKNEESLKK 748
K+ +AE QK+ ++ ++ T + + K +D +Q + ++ ++ E K
Sbjct: 1164 NKK-REAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Query: 749 CVEDYLARITQEGQRYQALKAHAE-----------------EKLQLANEEIAQVRSKAQA 791
+ L +T ++ KA+ E E+ Q + ++ R+K Q
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQT 1282
Query: 792 EALALQASLRKEQMRIQSLEKTVEQKTKENEELTR 826
E L L +++ I L + T++ E+L R
Sbjct: 1283 ENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR 1317
Score = 38.5 bits (88), Expect = 0.026
Identities = 41/215 (19%), Positives = 90/215 (41%), Gaps = 15/215 (6%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQKQKE 695
LQ ++ D D +++ EE E ++ + + K N E+ + ++E Q EE+++ K+
Sbjct: 1333 LQSARHDCD-LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK 1391
Query: 696 LSKAEIQKVLKEKDQLTTDLNSMEKS-------FSDLFKRFEKQKEVIEGYRKNEESLKK 748
+Q+ + + + +S+EK+ DL E+ K + + K
Sbjct: 1392 KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1451
Query: 749 CVEDYLARITQEGQRYQALKAHAEE------KLQLANEEIAQVRSKAQAEALALQASLRK 802
+ ++ + + ++ + A KL+ A EE + + E LQ +
Sbjct: 1452 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1511
Query: 803 EQMRIQSLEKTVEQKTKENEELTRICDDLISKMEK 837
++ S KT+ + K ++L +L S +E+
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE 1546
Score = 36.6 bits (83), Expect = 0.099
Identities = 53/226 (23%), Positives = 91/226 (40%), Gaps = 33/226 (14%)
Query: 629 STGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGK----NLELGKIMDRFEEVVY 684
S+G + L+ +K L+A Q E + E GK LE +I E +
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 685 QAMEEVQKQK--------------ELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFK-RF 729
+ EE+++ K + + L+ K ++ DLN ME S +
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637
Query: 730 EKQKEVIEGYRKNEESLKKCVE---DYLARITQEGQRYQALKAHAEEKLQLANEEIAQV- 785
E QK+V K+ +SL K + D R + + A+ LQ EE+ V
Sbjct: 1638 EAQKQV-----KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1692
Query: 786 ----RSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRI 827
RS+ AE ++ S R + + Q+ + QK K + +L+++
Sbjct: 1693 EQTERSRKLAEQELIETSERVQLLHSQN-TSLINQKKKMDADLSQL 1737
Score = 33.9 bits (76), Expect = 0.64
Identities = 50/225 (22%), Positives = 102/225 (45%), Gaps = 32/225 (14%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
+D L+ + ++ AT+ + + L L +L K +E QA++++Q +
Sbjct: 954 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013
Query: 694 KE----LSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRK-NEESL-- 746
++ L+KA++ K+ ++ D L L +K DL E+ K +EG K +ES+
Sbjct: 1014 EDKVNTLTKAKV-KLEQQVDDLEGSLEQEKKVRMDL----ERAKRKLEGDLKLTQESIMD 1068
Query: 747 ----KKCVEDYL-----------ARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQA 791
K+ +++ L ARI E QAL + ++KL+ I ++ + +A
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDE----QALGSQLQKKLKELQARIEELEEELEA 1124
Query: 792 EALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKME 836
E A +A + K + + + + ++ +E T + ++ K E
Sbjct: 1125 ERTA-RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
Score = 30.8 bits (68), Expect = 5.5
Identities = 38/182 (20%), Positives = 82/182 (45%), Gaps = 27/182 (14%)
Query: 656 RELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKD------ 709
RE ++ EE+ +LG E +E+V+KQ E K E+Q L+E +
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHE-----LEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 710 -----QLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRY 764
+ + N ++ +++ ++ ++ E +E ++N + ++ L T+ R
Sbjct: 1555 EGKILRAQLEFNQIK---AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR--SRN 1609
Query: 765 QALKAHAEEKLQLANEEIA-----QVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTK 819
+AL+ + + L EI ++ ++AQ + +LQ+ L+ Q+++ + K
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR-ANDDLK 1668
Query: 820 EN 821
EN
Sbjct: 1669 EN 1670
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/194 (23%), Positives = 93/194 (47%), Gaps = 20/194 (10%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
+V L+Q + DL V+A E + RC++L +L + +EV +A +E +
Sbjct: 878 LVTLVQ-EKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEA---KIKEVTERAEDEEEI 933
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
EL+ A+ +K+ E +L D++ +E + + + EK+K E KN +++
Sbjct: 934 NAELT-AKKRKLEDECSELKKDIDDLELTLA----KVEKEKHATENKVKNLTEELSGLDE 988
Query: 753 YLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK 812
+A++T+E + Q A + LQ +++ +L + K + +++ LE
Sbjct: 989 TIAKLTREKKALQEAHQQALDDLQAEEDKVN-----------SLNKTKSKLEQQVEDLES 1037
Query: 813 TVEQKTKENEELTR 826
++EQ+ K +L R
Sbjct: 1038 SLEQEKKLRVDLER 1051
Score = 47.8 bits (112), Expect = 4e-05
Identities = 44/212 (20%), Positives = 101/212 (47%), Gaps = 22/212 (10%)
Query: 637 LQYSQKDLDAV---VKATQEENRELRSRCEELH---GKNLELGKIMDRFEEVVYQAMEEV 690
LQ S++ ++AV + ++ + L+ E+L + L +D+ + + + E
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457
Query: 691 QKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCV 750
+ + E S+AE++ LKE L+T+L ++ + +E+ + +E ++ ++L++ +
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNA-------YEEALDQLETVKRENKNLEQEI 1510
Query: 751 EDYLARITQEGQRYQALKAHAEE------KLQLANEEIAQVRSKAQAEALALQASLRKEQ 804
D +I + G+ L+ ++ +QLA EE +A+ L +Q L + +
Sbjct: 1511 ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570
Query: 805 MRIQSLEKTVEQKTKENEELTRICDDLISKME 836
I ++ + +K +E E+L R + M+
Sbjct: 1571 SEI---DRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Score = 43.9 bits (102), Expect = 6e-04
Identities = 44/187 (23%), Positives = 84/187 (44%), Gaps = 19/187 (10%)
Query: 641 QKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAE 700
Q+DL + + L++ EEL LE +R ++ Q + + ++ +L +
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRA-TLEQ---TERARKLAEQELLDSNERVQLLHTQ 1720
Query: 701 IQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQE 760
++ K +L TDL ++ D + R EE KK + D A + +E
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASR----------DARNAEEKAKKAITD-AAMMAEE 1769
Query: 761 GQRYQALKAHAEEKLQLANEEIAQVRSKA-QAEALALQA---SLRKEQMRIQSLEKTVEQ 816
++ Q AH E + + + ++ + +AE LAL+ ++K + RI+ LE +E
Sbjct: 1770 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEG 1829
Query: 817 KTKENEE 823
+ K+N E
Sbjct: 1830 EQKKNTE 1836
Score = 40.8 bits (94), Expect = 0.005
Identities = 50/201 (24%), Positives = 92/201 (45%), Gaps = 20/201 (9%)
Query: 653 EENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELS---KAEIQKVLKEK- 708
E +E+ + EE EL K + +E+ + + VQ++ +L +AE + +L +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 709 --DQLTTDLNSMEKSFSDLFKRFEKQKEV----IEGYRKNEES---LKKCVEDY---LAR 756
DQL +E ++ +R E ++E+ RK E+ LKK ++D LA+
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 757 ITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQ 816
+ +E + + E+L +E IA K E ALQ + ++ +Q+ E V
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIA----KLTREKKALQEAHQQALDDLQAEEDKVNS 1020
Query: 817 KTKENEELTRICDDLISKMEK 837
K +L + +DL S +E+
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQ 1041
Score = 40.0 bits (92), Expect = 0.009
Identities = 45/212 (21%), Positives = 93/212 (43%), Gaps = 30/212 (14%)
Query: 642 KDLDAVVKATQEE---NRELRSRCEELHGKNL-ELGKIMDRFEEV--VYQAMEEVQKQKE 695
K+L A ++ +EE R R++ E+ EL ++ +R EE V E+ K++E
Sbjct: 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKRE 1169
Query: 696 LSKAEIQKVLKEKDQLTTDLNSM--------EKSFSDLFKRFEKQKEVIEGYRKNEESLK 747
AE K+ ++ ++ T +M S ++L ++ + + V + K + K
Sbjct: 1170 ---AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226
Query: 748 KCVEDY-------------LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEAL 794
++D L +I + + + E++Q + E+ +S+ Q EA
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 795 ALQASLRKEQMRIQSLEKTVEQKTKENEELTR 826
L L +++ + L ++ + T++ EEL R
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKR 1318
Score = 39.3 bits (90), Expect = 0.015
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 13/163 (7%)
Query: 652 QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQ---KQKELSKAEIQKVLKEK 708
Q EL ++ L + EL + ++ E +V Q Q +Q E K ++++ K K
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK 1327
Query: 709 DQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALK 768
+ L L S L +++E+++E + L++ + + + Q +Y+
Sbjct: 1328 NALAHALQSSRHDCDLLREQYEEEQE-------GKAELQRALSKANSEVAQWRTKYETDA 1380
Query: 769 AHAEEKLQLANEEIAQ--VRSKAQAEAL-ALQASLRKEQMRIQ 808
E+L+ A +++AQ S+ Q EA+ A ASL K + R+Q
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Score = 35.8 bits (81), Expect = 0.17
Identities = 41/209 (19%), Positives = 87/209 (41%), Gaps = 35/209 (16%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKEL 696
LQ S+ D D + + +EE L N E+ + ++E Q EE+++ K+
Sbjct: 1334 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393
Query: 697 SKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLAR 756
+Q ++ + + S+EK+ ++ L+ VED +
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKT---------------------KQRLQGEVEDLMVD 1432
Query: 757 ITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEK---- 812
+ +R +L A ++K + ++ +A+ ++K + L+ASL++ + L K
Sbjct: 1433 V----ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNA 1488
Query: 813 ------TVEQKTKENEELTRICDDLISKM 835
+E +EN+ L + DL ++
Sbjct: 1489 YEEALDQLETVKRENKNLEQEIADLTEQI 1517
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/191 (23%), Positives = 88/191 (46%), Gaps = 19/191 (9%)
Query: 640 SQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKA 699
SQ+DL + + L++ EEL LE +R ++ Q + + ++ +L
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRA-TLEQ---TERSRKIAEQELLDASERVQLLHT 1722
Query: 700 EIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQ 759
+ ++ K +L TD++ ++ D +I+ R EE KK + D A + +
Sbjct: 1723 QNTSLINTKKKLETDISQIQGEMED----------IIQEARNAEEKAKKAITD-AAMMAE 1771
Query: 760 EGQRYQALKAHAEEKLQLANEEIAQVRSKA-QAEALALQA---SLRKEQMRIQSLEKTVE 815
E ++ Q AH E + + + ++ + +AE LAL+ ++K + R++ LE VE
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1831
Query: 816 QKTKENEELTR 826
+ K N E +
Sbjct: 1832 SEQKRNVEAVK 1842
Score = 45.4 bits (106), Expect = 2e-04
Identities = 50/226 (22%), Positives = 97/226 (42%), Gaps = 33/226 (14%)
Query: 631 GPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEV 690
G +D LQ ++ L+ + E +L S E + L K+ E+ + + +
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKE 1267
Query: 691 QKQKEL-------------SKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQ-KEVI 736
++Q+ L E + L EKD L + L+ +++F+ + ++Q +E I
Sbjct: 1268 EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Query: 737 EGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALA- 795
+ +L+ D + ++ + Q KA + + AN E+AQ R+K + +A+
Sbjct: 1328 KAKSALAHALQSSRHD-CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1386
Query: 796 ---LQASLRKEQMRIQ--------------SLEKTVEQKTKENEEL 824
L+ + +K R+Q SLEKT ++ E E+L
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1432
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/222 (21%), Positives = 95/222 (42%), Gaps = 28/222 (12%)
Query: 637 LQYSQKDLDAVVKATQEE---NRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQK 692
LQ K+L A ++ +EE R R++ E+ + EL +I +R EE +++
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167
Query: 693 QKELSKAEIQKVLKEKDQLT----------------------TDLNSMEKSFSDLFKRFE 730
K+ +AE QK+ ++ ++ T ++++++ L K
Sbjct: 1168 NKK-REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1226
Query: 731 KQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQ 790
+ K I+ N E++ K + + +K EE+ +L N+ AQ R++ Q
Sbjct: 1227 EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ-RARLQ 1285
Query: 791 AEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLI 832
E+ L ++ + L + + T++ EEL R ++ I
Sbjct: 1286 TESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Score = 41.2 bits (95), Expect = 0.004
Identities = 44/210 (20%), Positives = 91/210 (43%), Gaps = 26/210 (12%)
Query: 637 LQYSQKDLDAVVKATQEE--NRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQK 694
+Q K + +A EE N EL ++ +L + EL K +D E + +V+K+K
Sbjct: 917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE----LTLAKVEKEK 972
Query: 695 ELSKAEIQKVLKEKD-------QLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLK 747
++ +++ + +E +LT + +++++ + +++ + K + L+
Sbjct: 973 HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1032
Query: 748 KCVEDYLARITQEGQRYQAL---KAHAEEKLQLANEEIAQVRS----------KAQAEAL 794
+ V+D + QE + L K E L+LA E + + K + E
Sbjct: 1033 QQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMS 1092
Query: 795 ALQASLRKEQMRIQSLEKTVEQKTKENEEL 824
LQ+ + EQ L+K +++ EEL
Sbjct: 1093 GLQSKIEDEQALGMQLQKKIKELQARIEEL 1122
Score = 39.3 bits (90), Expect = 0.015
Identities = 49/204 (24%), Positives = 88/204 (43%), Gaps = 26/204 (12%)
Query: 653 EENRELRSRCEELHGKNLELGKIMDRFEEV------VYQAMEEVQKQKELSKAEIQKVLK 706
E +E+ + EE EL K + +E+ + Q ++Q Q + + +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 707 EKDQLTTDLNSMEKSFSDLFKRFEKQKEV----IEGYRKNEES---LKKCVEDY---LAR 756
DQL +E ++ +R E ++E+ RK E+ LKK ++D LA+
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 757 ITQEGQRYQALKAHAEEKLQLANEEIA---QVRSKAQAEALALQASLRKEQMRIQSLEKT 813
+ +E K E K++ EE+A + +K E ALQ + ++ +Q+ E
Sbjct: 968 VEKE-------KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020
Query: 814 VEQKTKENEELTRICDDLISKMEK 837
V TK +L + DDL +E+
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQ 1044
Score = 38.9 bits (89), Expect = 0.020
Identities = 43/221 (19%), Positives = 88/221 (39%), Gaps = 22/221 (9%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGK-NLELGKIMDRFEEVVYQAMEEVQKQKE 695
LQ S+ D D +++ EE +E ++ + K N E+ + ++E Q EE+++ K+
Sbjct: 1337 LQSSRHDCD-LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 696 LSKAEIQKVLKEKDQLTTDLNSMEKS-------FSDLFKRFEKQKEVIEGYRKNEESLKK 748
+Q + + + S+EK+ DL E+ K + + K
Sbjct: 1396 KLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDK 1455
Query: 749 CVEDYLARITQEGQRYQALKAHAEE------KLQLANEE-------IAQVRSKAQAEALA 795
+ ++ + + +A + + K++ A EE + + Q E
Sbjct: 1456 ILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1515
Query: 796 LQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKME 836
L + + RI LEK +Q +E EL ++ + +E
Sbjct: 1516 LTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 1556
Score = 38.5 bits (88), Expect = 0.026
Identities = 49/205 (23%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 644 LDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQK 703
L+ + Q E +L E + L K F+++ + E +++ E + AE++
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI----LAEWKQKCEETHAELEA 1473
Query: 704 VLKEKDQLTTDL----NSMEKSFSDL--FKRFEK--QKEVIE--------GYRKNE-ESL 746
KE L+T+L N+ E+S L KR K Q+E+ + G R +E E +
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1533
Query: 747 KKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQ---AEALALQASLRKE 803
KK VE + + + +A H E K+ E+ QV+S+ AE +++
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN 1593
Query: 804 QMRI-QSLEKTVEQKTKENEELTRI 827
+RI +S++ T++ + + + R+
Sbjct: 1594 HIRIVESMQSTLDAEIRSRNDAIRL 1618
Score = 37.0 bits (84), Expect = 0.076
Identities = 44/193 (22%), Positives = 85/193 (44%), Gaps = 25/193 (12%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKEL 696
L + DL V+A + + RC++L ++L + +EV +A +E + EL
Sbjct: 884 LMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEINAEL 940
Query: 697 SKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLAR 756
+ A+ +K+ E +L D++ +E + + + EK+K E K
Sbjct: 941 T-AKKRKLEDECSELKKDIDDLELTLA----KVEKEKHATENKVK--------------N 981
Query: 757 ITQE--GQRYQALKAHAEEK-LQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKT 813
+T+E G K E+K LQ A+++ + + L + K + ++ LE +
Sbjct: 982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1041
Query: 814 VEQKTKENEELTR 826
+EQ+ K +L R
Sbjct: 1042 LEQEKKIRMDLER 1054
Score = 34.7 bits (78), Expect = 0.38
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 29/209 (13%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
+D L+ + ++ AT+ + + L L +L K +E Q ++++Q +
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 694 KE----LSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKN------- 742
++ L+KA+I K+ ++ D L L +K DL E+ K +EG K
Sbjct: 1018 EDKVNTLTKAKI-KLEQQVDDLEGSLEQEKKIRMDL----ERAKRKLEGDLKLAQESTMD 1072
Query: 743 --------EESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEAL 794
+E LKK E ++ + + + QAL ++K++ I ++ + +AE
Sbjct: 1073 IENDKQQLDEKLKK-KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE-- 1129
Query: 795 ALQASLRKEQMRIQSLEKTVEQKTKENEE 823
+AS K + + L + +E+ ++ EE
Sbjct: 1130 --RASRAKAEKQRSDLSRELEEISERLEE 1156
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 12/194 (6%)
Query: 653 EENRELRSRCEELHGKNLE-LGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQL 711
E+N+E RS E + E + + M++ +E + ME Q+QK +AEI+++ E +
Sbjct: 266 EKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQ 325
Query: 712 TTDLNSMEKSFSDLFKRFEKQKEVIEG-YRKNEESLKKCVEDYLARITQEGQRYQALKAH 770
+L + EK + F K+K E + +E +++ E +AR+ ++ Q +A
Sbjct: 326 KAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAE 385
Query: 771 AEEKLQLANEEIA----------QVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKE 820
+ N+E+A R K + EA ++ L + + +L V++ E
Sbjct: 386 QDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDE 445
Query: 821 NEELTRICDDLISK 834
E + R + I K
Sbjct: 446 FERILRAQREQIEK 459
Score = 38.9 bits (89), Expect = 0.020
Identities = 37/185 (20%), Positives = 85/185 (45%), Gaps = 24/185 (12%)
Query: 658 LRSRCEELHGKNL----ELGKIMDRFEEVVYQAME-----EVQKQKELSKAEIQKVLKEK 708
L ++C + + ++ K +D E+ + Q ME +Q+Q+EL + ++ ++ +
Sbjct: 199 LNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGR 258
Query: 709 DQLTTDLNSMEKSFSDLFKRFEKQKEVIEGY-------------RKNEESLKKCVEDYLA 755
Q+ + ++ S L ++ E++KE + Y R+ ++ LK E +
Sbjct: 259 RQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAE--IK 316
Query: 756 RITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVE 815
RI E Q+ +A E+ E + + +AE A Q +R+E+ + + + ++
Sbjct: 317 RINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQ 376
Query: 816 QKTKE 820
+K ++
Sbjct: 377 EKAQD 381
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 51.6 bits (122), Expect = 3e-06
Identities = 48/211 (22%), Positives = 102/211 (48%), Gaps = 24/211 (11%)
Query: 652 QEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAME------------EVQKQKELSK- 698
+EE R LRS ++L+ +N +L + ++ E + Q + ++Q+ KEL
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENK 2568
Query: 699 -AEIQKVLKEKDQLTTDL----NSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKK--CVE 751
A++++ LKE ++ DL N++++ DL K E K I + +L++ +
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Query: 752 DYLARIT---QEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQ 808
Y A++ +E R AL + +++++ EE+ V+ +A + ++ L+KE +
Sbjct: 2629 LYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLH 2688
Query: 809 SLEKTVEQKTKENEE-LTRICDDLISKMEKI 838
+ +T+ EE + + DL+ +K+
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKL 2719
Score = 47.4 bits (111), Expect = 6e-05
Identities = 46/197 (23%), Positives = 89/197 (45%), Gaps = 11/197 (5%)
Query: 638 QYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELS 697
Q Q+ L A + + +E +E +S EEL + ++ +V Q + K+K+
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQ-NKEKDTV 1537
Query: 698 KAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDY---- 753
+ + +E+D+L T+++ L E K +EG +++E L K +E
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
Query: 754 LARITQEGQRYQALKAHAEEKLQ----LAN--EEIAQVRSKAQAEALALQASLRKEQMRI 807
+A T+ ++++ L+ E LQ ++N E I V + E L LR +
Sbjct: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
Query: 808 QSLEKTVEQKTKENEEL 824
+ EK +++ +E EE+
Sbjct: 1658 KETEKQLQEAEQEMEEM 1674
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/207 (17%), Positives = 86/207 (41%), Gaps = 14/207 (6%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGKNL-------ELGKIMDRFEEVVYQAMEE 689
L S + L ++ E+ +L E L + E K + + E++ Q+ E
Sbjct: 1565 LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624
Query: 690 VQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKC 749
V + E + ++ V +EK +L L S E + + K+ ++ ++ +E ++ K
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1684
Query: 750 VEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQS 809
+ + + +E R +A ++ A + + + +++ L + +M ++
Sbjct: 1685 KQQKILELEEENDRLRA-------EVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
Query: 810 LEKTVEQKTKENEELTRICDDLISKME 836
L K + E + L+ DL ++E
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
Score = 43.5 bits (101), Expect = 8e-04
Identities = 57/230 (24%), Positives = 111/230 (48%), Gaps = 27/230 (11%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHG----KNLELGKI------MDRFEEV 682
++ LQ ++ ++ V E R + S+ EEL K LE+ K+ R E
Sbjct: 832 LIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVET 891
Query: 683 VYQAMEEVQKQ-KELSKAEIQKVLK---EKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEG 738
+ Q +EE +Q E+S + +K+++ EK L ++ ++++ + L + E +KE +E
Sbjct: 892 LQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEE 951
Query: 739 YRKNEESLKKCVEDY--LARITQE--GQRYQALKAHAEE---KLQLA---NEEIAQVRSK 788
+ LK+ ++ +I++E + LK E+ KLQ A +E+ Q S+
Sbjct: 952 DNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR 1011
Query: 789 AQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
+ E L+ +KE + + E+ ++ KEN+E + C + SK ++I
Sbjct: 1012 LEEELANLKDESKKE-IPLSETERGEVEEDKENKEYSEKC--VTSKCQEI 1058
Score = 41.2 bits (95), Expect = 0.004
Identities = 47/193 (24%), Positives = 87/193 (45%), Gaps = 19/193 (9%)
Query: 639 YSQKDLDAVVK--ATQEENRELRSRCEELHGKNLELGKIMDRFE-EVVYQAMEEVQ-KQK 694
Y Q DA +K + E + L+ EL + +L K + E E+ + +E++Q QK
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 695 ELSKA----EIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCV 750
E E+Q++LKEK Q L + + E+ + +E + + +
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
Query: 751 EDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSL 810
++ LA+ + ++ QA A + L E A+V LA L+KE +QS
Sbjct: 2060 KENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV--------LADNLKLKKE---LQSN 2108
Query: 811 EKTVEQKTKENEE 823
+++V+ + K+ +E
Sbjct: 2109 KESVKSQMKQKDE 2121
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/212 (22%), Positives = 90/212 (42%), Gaps = 22/212 (10%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEEL----HGKNLELGKIMDRFEEVVYQ------A 686
+Q QK D + Q EN+EL S+ EE H EL K+ + + Q +
Sbjct: 2272 VQLQQKVCDTL----QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2327
Query: 687 MEEVQKQK-------ELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFE-KQKEVIEG 738
+E+ ++QK +A+IQ +QL TDL + + S L + K++++I
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL 2387
Query: 739 YRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQA 798
EE+++ + + + +E + + L + EE+ + EE + K L+
Sbjct: 2388 LSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 799 SLRKEQMRIQSLEKTVEQKTKENEELTRICDD 830
++ + L+ V+ + + RI D
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGD 2479
Score = 36.6 bits (83), Expect = 0.099
Identities = 41/191 (21%), Positives = 82/191 (42%), Gaps = 14/191 (7%)
Query: 641 QKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMD------RFEEV-VYQAMEEVQKQ 693
Q + ++V ++++ +L R E+ K+L+ K M R E+V + + + E+Q
Sbjct: 2106 QSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVT 2165
Query: 694 KELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDY 753
E+Q++ + D T L + KS S L + + VI+ +K E ++
Sbjct: 2166 LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL---QDDRDRVIDEAKKWERKFSDAIQSK 2222
Query: 754 LARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKT 813
I + LK + + + EE+ S+ + + ++ K Q +Q +K
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQ-MSIHMEELKINISRLEHDKQIWES---KAQTEVQLQQKV 2278
Query: 814 VEQKTKENEEL 824
+ EN+EL
Sbjct: 2279 CDTLQGENKEL 2289
Score = 35.8 bits (81), Expect = 0.17
Identities = 46/256 (17%), Positives = 110/256 (42%), Gaps = 55/256 (21%)
Query: 629 STGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEV--VYQA 686
S + D+ Q Q +L+ + E + +E++ KNL+ ++ +E+ + Q
Sbjct: 671 SLSAVPDIGQCHQDELERLKSQILELELNFH-KAQEIYEKNLD-----EKAKEISNLNQL 724
Query: 687 MEEVQKQKELSKAEIQKVLKEKDQL---------TTDLNSMEKSFSDLFKRFEKQKEV-- 735
+EE +K + + + + +E+DQL T+L + K E+Q+ +
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
Query: 736 ------------------IEGYRKNE--ESLKKCVEDYLARITQEGQRYQALKAHAEEK- 774
IE K+ E L+ ++D + +++ ++L++ + K
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
Query: 775 ------------LQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENE 822
+ EE++Q S+ + E + L +++ +++L++T+E+K ++
Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK---DQ 901
Query: 823 ELTRICDDLISKMEKI 838
++T I + KM ++
Sbjct: 902 QVTEISFSMTEKMVQL 917
Score = 35.8 bits (81), Expect = 0.17
Identities = 48/242 (19%), Positives = 103/242 (42%), Gaps = 36/242 (14%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCE---------ELHGKNLELGKIMDRFEEVV 683
++D + ++ +++ +EE R C +H + L++ ++ +
Sbjct: 2204 VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQI 2263
Query: 684 YQ--AMEEVQKQKE------------LSKAEIQKVLKEKDQ-----LTTDLNSMEKSFSD 724
++ A EVQ Q++ LS+ E + L Q L ++L S++ +D
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD 2323
Query: 725 LFKRFEK---QKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEE 781
L EK QK +EG + +E+ + + ++ + Q + L + E++ + ++
Sbjct: 2324 LSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQK 2383
Query: 782 IAQVRS-KAQAEALALQASLRKEQMRIQSLEKTVEQKTKEN----EELTRICDDLISKME 836
I + S K +A +A+ ++ I+ LE + Q+ +EN EE + D ME
Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME 2443
Query: 837 KI 838
+
Sbjct: 2444 TL 2445
Score = 35.4 bits (80), Expect = 0.22
Identities = 52/220 (23%), Positives = 97/220 (44%), Gaps = 49/220 (22%)
Query: 642 KDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEI 701
K+ A ++ +++N+E E + KN L +I + E+ EEV K L+
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLE--NEKNTLLSQISTKDGELK-MLQEEVTKMNLLN---- 1898
Query: 702 QKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQ------------KEVIEGYRKNE------ 743
Q++ +E ++T + E+ DL +R Q ++V + KNE
Sbjct: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEM 1958
Query: 744 ESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKE 803
++LKKCV + EEK QL E+ +V S+ + E L +KE
Sbjct: 1959 KNLKKCVSEL-----------------EEEKQQLVKEK-TKVESEIRKEYLEKIQGAQKE 2000
Query: 804 ---QMRIQSLEKTVEQKTKENEELTRIC---DDLISKMEK 837
+ + L++ +++K +E ++L + C + IS +E+
Sbjct: 2001 PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
Score = 32.7 bits (73), Expect = 1.4
Identities = 38/165 (23%), Positives = 69/165 (41%), Gaps = 19/165 (11%)
Query: 674 KIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQK 733
K+ + E +V +A Q+EL+ AE + + L+ L ME + L +
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRNQI-----LSQQLQQMEAEHNTL-------R 307
Query: 734 EVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEA 793
+E R+ + L + +E +A Q H E+ + A + A++ S+ A
Sbjct: 308 NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367
Query: 794 LALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI 838
+A + ++ I SL+KT +EL CD L + K+
Sbjct: 368 QKHKAEMEEKTSHILSLQKT-------GQELQSACDALKDQNSKL 405
Score = 30.8 bits (68), Expect = 5.5
Identities = 36/191 (18%), Positives = 83/191 (43%), Gaps = 7/191 (3%)
Query: 653 EENRELRSRCEELHGKNLELG-KIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQL 711
+EN+E +C + +E+ K +EV Q + + ++K ++ + Q ++K+ +Q
Sbjct: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
Query: 712 ----TTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQAL 767
T ++ ++ S+ + QK + ++ V++ + +
Sbjct: 1101 LQDKTNQIDLLQAEISE--NQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHW 1158
Query: 768 KAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRI 827
K EEK+ +E Q++ K Q + +A L+K Q + + L + ++Q+ + L
Sbjct: 1159 KPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQ 1218
Query: 828 CDDLISKMEKI 838
D+ + E I
Sbjct: 1219 FDEQSKENENI 1229
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 51.2 bits (121), Expect = 4e-06
Identities = 48/210 (22%), Positives = 96/210 (45%), Gaps = 12/210 (5%)
Query: 633 IVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQK 692
I+ LQ + D + +K +EEN L EEL K + K E+ + Q ME++ K
Sbjct: 997 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELR-KQADKAKAAQTAEDAM-QIMEQMTK 1054
Query: 693 QKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVED 752
+K + A ++ + +L +L++++++ + K KE++ + E +K +E
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIET 1114
Query: 753 YLARITQEGQRYQALKAHAEEKLQLANEEIAQVR------SKAQAEALALQASLRKEQMR 806
Q+ Q+ AL+ EE ++LA EE+ + R K + E L L + + R
Sbjct: 1115 LKQAAAQKSQQLSALQ---EENVKLA-EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1170
Query: 807 IQSLEKTVEQKTKENEELTRICDDLISKME 836
K +++ ++ I L+++ +
Sbjct: 1171 ESKFIKDADEEKASLQKSISITSALLTEKD 1200
Score = 50.8 bits (120), Expect = 5e-06
Identities = 50/223 (22%), Positives = 104/223 (46%), Gaps = 26/223 (11%)
Query: 637 LQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKEL 696
L+ ++K + + E+ + S EL G+ L+L + + EV Q E ++K+ ++
Sbjct: 751 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS-QVKETLEKELQI 809
Query: 697 SKAE------------------IQKVLKEKDQ---LTTDLNSMEKSFSDLFKRFEKQKEV 735
K + + K+ ++++Q L++DL + ++ +D+ +F ++ E
Sbjct: 810 LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
Query: 736 IEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVR-SKAQAEAL 794
E K +E L+ + + + Q K + E +L+ + E Q++ +KA A
Sbjct: 870 EEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERDVEELQLKLTKANENAS 927
Query: 795 ALQASLRKEQMRI-QSLEKTVEQKTKENEELTRICDDLISKME 836
LQ S+ ++ QS ++ ++ +E +EL R DL KME
Sbjct: 928 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKME 970
Score = 37.4 bits (85), Expect = 0.058
Identities = 45/221 (20%), Positives = 92/221 (41%), Gaps = 28/221 (12%)
Query: 634 VDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQ 693
++ L+ + D++A + E +L E+L E+ K+ + + +E+ +
Sbjct: 849 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL-RL 907
Query: 694 KELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEK-QKEVIEGYRKNEESLKKCVED 752
KE E+Q L + ++ + + ++KS D+ + E+ Q+E + + + ++ L++ + D
Sbjct: 908 KERDVEELQLKLTKANE---NASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 964
Query: 753 YLARITQEGQRYQALKA---HAEEKLQLANEEIAQVRSKA-------------------- 789
++ + Q LKA A + + +EEI Q K
Sbjct: 965 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1024
Query: 790 QAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDD 830
+ E L QA K + + +EQ TKE E +D
Sbjct: 1025 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Score = 31.2 bits (69), Expect = 4.2
Identities = 40/209 (19%), Positives = 88/209 (42%), Gaps = 11/209 (5%)
Query: 641 QKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAE 700
QK++ A+ AT++ ++E S +L N E ++ ++ + A+ Q+ E K
Sbjct: 539 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 598
Query: 701 IQKVL----KEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIE-GYRKNEESLKKCVEDYLA 755
K L E +L T + M + + + Q++ + K E+L+ + +
Sbjct: 599 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 658
Query: 756 RITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRK--EQMRI----QS 809
+ ++ AE++ + E+ +A+ + L+ K EQ ++ S
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 810 LEKTVEQKTKENEELTRICDDLISKMEKI 838
K E+K + + L + + S+M+K+
Sbjct: 719 QLKATEEKLLDLDALRKASSEGKSEMKKL 747
Score = 30.0 bits (66), Expect = 9.3
Identities = 37/164 (22%), Positives = 71/164 (43%), Gaps = 13/164 (7%)
Query: 684 YQAMEEV-QKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKE-VIEGYRK 741
+ A EE QK+ + +K+ KE + L + L K SD+ ++ + E I +++
Sbjct: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
Query: 742 NEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALA---LQA 798
E LK L T E + LK E+ EI ++++ +E A
Sbjct: 591 AMEELKVSFSKGLGTETAE---FAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEME 647
Query: 799 SLRKEQMRI-----QSLEKTVEQKTKENEELTRICDDLISKMEK 837
+LR + M++ SLE + K ++ +D ++K+++
Sbjct: 648 ALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 691
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,776,092
Number of Sequences: 37866
Number of extensions: 2316318
Number of successful extensions: 18609
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 201
Number of HSP's successfully gapped in prelim test: 1207
Number of HSP's that attempted gapping in prelim test: 13797
Number of HSP's gapped (non-prelim): 5463
length of query: 838
length of database: 18,247,518
effective HSP length: 111
effective length of query: 727
effective length of database: 14,044,392
effective search space: 10210272984
effective search space used: 10210272984
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.