Guide to the Human Genome
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Search of human proteins with 5453882

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
         (387 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]        785   0.0  
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]      512   e-145
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   203   2e-52
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   203   2e-52
gi|212549753 calcium/calmodulin-dependent protein kinase II delt...   203   2e-52
gi|26667186 calcium/calmodulin-dependent protein kinase II delta...   203   2e-52
gi|26667189 calcium/calmodulin-dependent protein kinase II delta...   203   2e-52
gi|26667180 calcium/calmodulin-dependent protein kinase II delta...   203   2e-52
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...   202   5e-52
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...   202   5e-52
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...   201   9e-52
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma...   201   9e-52
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma...   201   9e-52
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma...   201   9e-52
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma...   201   9e-52
gi|149589021 doublecortin-like kinase 3 [Homo sapiens]                198   6e-51
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s...   197   1e-50
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ...   197   2e-50
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ...   196   2e-50
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   196   3e-50
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   196   3e-50
gi|4557511 death-associated protein kinase 3 [Homo sapiens]           186   2e-47
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   186   2e-47

>gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
          Length = 387

 Score =  785 bits (2027), Expect = 0.0
 Identities = 387/387 (100%), Positives = 387/387 (100%)

Query: 1   MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS 60
           MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS
Sbjct: 1   MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS 60

Query: 61  PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV 120
           PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV
Sbjct: 61  PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV 120

Query: 121 TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER 180
           TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER
Sbjct: 121 TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER 180

Query: 181 LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR 240
           LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR
Sbjct: 181 LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR 240

Query: 241 MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS 300
           MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
Sbjct: 241 MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS 300

Query: 301 PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK 360
           PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK
Sbjct: 301 PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK 360

Query: 361 KGQQQNRAALFENTPKAVLLSLAEEDY 387
           KGQQQNRAALFENTPKAVLLSLAEEDY
Sbjct: 361 KGQQQNRAALFENTPKAVLLSLAEEDY 387


>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
          Length = 406

 Score =  512 bits (1319), Expect = e-145
 Identities = 240/372 (64%), Positives = 306/372 (82%), Gaps = 1/372 (0%)

Query: 4   DEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEE 63
           ++ LPD  +A++FY+ Y+PK+++GRGVSSVVRRC+H+ T  E+AVK+++VT     SPE+
Sbjct: 8   EDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE-RLSPEQ 66

Query: 64  VRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLS 123
           + E+REAT +E  ILR+V+GHP+II L D+YE+++F FLVFDLM++GELFDYLTEKV LS
Sbjct: 67  LEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALS 126

Query: 124 EKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLRE 183
           EKETR IMR+LLE +  LH  NIVHRDLKPENILLDDNM I+L+DFGFSC LEPGE+LRE
Sbjct: 127 EKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRE 186

Query: 184 VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM 243
           +CGTP YLAPEI++CSM+E HPGYGKEVD+W+ GVI++TLLAGSPPFWHR+Q+LMLRMIM
Sbjct: 187 LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIM 246

Query: 244 SGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRG 303
            G YQF SPEWDD S TVKDL+SR L V P+ R TAE+AL HPFF++    +  + +PR 
Sbjct: 247 EGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306

Query: 304 KFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQ 363
           +F+V   TVLA+ R+     RV+P+T+  ++RDPYALR +R LID  AFR+YGHWVKKG+
Sbjct: 307 RFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGE 366

Query: 364 QQNRAALFENTP 375
           QQNRAALF++ P
Sbjct: 367 QQNRAALFQHRP 378


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  203 bits (516), Expect = 2e-52
 Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E LG+G  SVVRRC+  PT QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H   IVHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VDMW+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHFS 300
           PEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F+
Sbjct: 236 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  203 bits (516), Expect = 2e-52
 Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E LG+G  SVVRRC+  PT QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H   IVHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VDMW+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHFS 300
           PEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F+
Sbjct: 236 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
           isoform 5 [Homo sapiens]
          Length = 492

 Score =  203 bits (516), Expect = 2e-52
 Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E LG+G  SVVRRC+  PT QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H   IVHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VDMW+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHFS 300
           PEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F+
Sbjct: 236 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  203 bits (516), Expect = 2e-52
 Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E LG+G  SVVRRC+  PT QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H   IVHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VDMW+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHFS 300
           PEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F+
Sbjct: 236 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  203 bits (516), Expect = 2e-52
 Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E LG+G  SVVRRC+  PT QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H   IVHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VDMW+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHFS 300
           PEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F+
Sbjct: 236 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
           isoform 3 [Homo sapiens]
          Length = 499

 Score =  203 bits (516), Expect = 2e-52
 Identities = 120/317 (37%), Positives = 173/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E LG+G  SVVRRC+  PT QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H   IVHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 ESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VDMW+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHFS 300
           PEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F+
Sbjct: 236 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  202 bits (513), Expect = 5e-52
 Identities = 118/318 (37%), Positives = 174/318 (54%), Gaps = 31/318 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F E Y+  E LG+G  SVVRRC+     QEYA K+I+       S  + ++L     +E 
Sbjct: 9   FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTK---KLSARDHQKLE----REA 61

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+       +L+FDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 62  RICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL 120

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +   H++ +VHRDLKPEN+LL   +    +KL DFG + ++E GE+       GTP Y
Sbjct: 121 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVE-GEQQAWFGFAGTPGY 179

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 180 LSPEVLR------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFP 233

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHF 299
           SPEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F
Sbjct: 234 SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKF 293

Query: 300 SPRGKFKVIALTVLASVR 317
           + R K K   LT + + R
Sbjct: 294 NARRKLKGAILTTMLATR 311


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score =  202 bits (513), Expect = 5e-52
 Identities = 118/318 (37%), Positives = 174/318 (54%), Gaps = 31/318 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F E Y+  E LG+G  SVVRRC+     QEYA K+I+       S  + ++L     +E 
Sbjct: 9   FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTK---KLSARDHQKLE----REA 61

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+       +L+FDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 62  RICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL 120

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +   H++ +VHRDLKPEN+LL   +    +KL DFG + ++E GE+       GTP Y
Sbjct: 121 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVE-GEQQAWFGFAGTPGY 179

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 180 LSPEVLR------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFP 233

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------QQYLVEEVRHF 299
           SPEWD  +   KDL+++ L + P  R TA EAL HP+            +Q  V+ ++ F
Sbjct: 234 SPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKF 293

Query: 300 SPRGKFKVIALTVLASVR 317
           + R K K   LT + + R
Sbjct: 294 NARRKLKGAILTTMLATR 311


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  201 bits (511), Expect = 9e-52
 Identities = 119/314 (37%), Positives = 177/314 (56%), Gaps = 31/314 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F ++Y+  E LG+G  SVVRRC+ K ++QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    +  +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +  +H+ +IVHRDLKPEN+LL        +KL DFG + +++ GE+       GTP Y
Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAGTPGY 180

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 181 LSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFP 234

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHF 299
           SPEWD  +   K+L+++ L + P  R TA++AL HP+            +Q  VE +R F
Sbjct: 235 SPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKF 294

Query: 300 SPRGKFKVIALTVL 313
           + R K K   LT +
Sbjct: 295 NARRKLKGAILTTM 308


>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
           isoform 4 [Homo sapiens]
          Length = 495

 Score =  201 bits (511), Expect = 9e-52
 Identities = 119/314 (37%), Positives = 177/314 (56%), Gaps = 31/314 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F ++Y+  E LG+G  SVVRRC+ K ++QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    +  +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +  +H+ +IVHRDLKPEN+LL        +KL DFG + +++ GE+       GTP Y
Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAGTPGY 180

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 181 LSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFP 234

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHF 299
           SPEWD  +   K+L+++ L + P  R TA++AL HP+            +Q  VE +R F
Sbjct: 235 SPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKF 294

Query: 300 SPRGKFKVIALTVL 313
           + R K K   LT +
Sbjct: 295 NARRKLKGAILTTM 308


>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
           isoform 6 [Homo sapiens]
          Length = 504

 Score =  201 bits (511), Expect = 9e-52
 Identities = 119/314 (37%), Positives = 177/314 (56%), Gaps = 31/314 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F ++Y+  E LG+G  SVVRRC+ K ++QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    +  +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +  +H+ +IVHRDLKPEN+LL        +KL DFG + +++ GE+       GTP Y
Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAGTPGY 180

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 181 LSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFP 234

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHF 299
           SPEWD  +   K+L+++ L + P  R TA++AL HP+            +Q  VE +R F
Sbjct: 235 SPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKF 294

Query: 300 SPRGKFKVIALTVL 313
           + R K K   LT +
Sbjct: 295 NARRKLKGAILTTM 308


>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
           isoform 1 [Homo sapiens]
          Length = 556

 Score =  201 bits (511), Expect = 9e-52
 Identities = 119/314 (37%), Positives = 177/314 (56%), Gaps = 31/314 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F ++Y+  E LG+G  SVVRRC+ K ++QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    +  +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +  +H+ +IVHRDLKPEN+LL        +KL DFG + +++ GE+       GTP Y
Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAGTPGY 180

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 181 LSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFP 234

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHF 299
           SPEWD  +   K+L+++ L + P  R TA++AL HP+            +Q  VE +R F
Sbjct: 235 SPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKF 294

Query: 300 SPRGKFKVIALTVL 313
           + R K K   LT +
Sbjct: 295 NARRKLKGAILTTM 308


>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
           isoform 2 [Homo sapiens]
          Length = 527

 Score =  201 bits (511), Expect = 9e-52
 Identities = 119/314 (37%), Positives = 177/314 (56%), Gaps = 31/314 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F ++Y+  E LG+G  SVVRRC+ K ++QEYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  HPNI++L D+     F +LVFDL+  GELF+ +  +   SE +    +  +L
Sbjct: 63  RICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR--EVCGTPSY 190
           E +  +H+ +IVHRDLKPEN+LL        +KL DFG + +++ GE+       GTP Y
Sbjct: 122 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAGTPGY 180

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 250
           L+PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F 
Sbjct: 181 LSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFP 234

Query: 251 SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHF 299
           SPEWD  +   K+L+++ L + P  R TA++AL HP+            +Q  VE +R F
Sbjct: 235 SPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKF 294

Query: 300 SPRGKFKVIALTVL 313
           + R K K   LT +
Sbjct: 295 NARRKLKGAILTTM 308


>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
          Length = 648

 Score =  198 bits (504), Expect = 6e-51
 Identities = 109/283 (38%), Positives = 167/283 (59%), Gaps = 23/283 (8%)

Query: 13  AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATL 72
           A +  ++YE   ++G G  +VV+ C H+ T Q YA+K+ID +         ++   +   
Sbjct: 349 AANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKS--------RLKGKEDMVD 400

Query: 73  KEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMR 132
            E+ I++ +S HPNI++L + YET+   +L+ + ++ G+LFD + E V   E +   ++ 
Sbjct: 401 SEILIIQSLS-HPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIM 459

Query: 133 ALLEVICTLHKLNIVHRDLKPENILL----DDNMNIKLTDFGFSCQLEPGERLREVCGTP 188
            L + +  +H  +IVHRDLKPEN+L+    D +  +KL DFG +  +     +  VCGTP
Sbjct: 460 DLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTP 517

Query: 189 SYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFW--HRKQMLMLRMIMSGN 246
           +Y+APEI+         GYG EVDMW+ GVI+Y LL G PPF    R Q  +  +I  G+
Sbjct: 518 TYVAPEIL------SEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGH 571

Query: 247 YQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQ 289
           ++F  P WD+ SD  KDLVSR LVV P+ RYTA + L HP+ +
Sbjct: 572 FEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIE 614


>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
           sapiens]
          Length = 370

 Score =  197 bits (502), Expect = 1e-50
 Identities = 107/284 (37%), Positives = 158/284 (55%), Gaps = 20/284 (7%)

Query: 8   PDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVREL 67
           P    A+D  + Y+ +++LG G  S V     K T +  A+K I          +E  E 
Sbjct: 8   PRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCI---------AKEALEG 58

Query: 68  REATLK-EVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKE 126
           +E +++ E+ +L K+  HPNI+ L D YE+    +L+  L+  GELFD + EK   +E++
Sbjct: 59  KEGSMENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD 117

Query: 127 TRKIMRALLEVICTLHKLNIVHRDLKPENIL---LDDNMNIKLTDFGFSCQLEPGERLRE 183
             +++  +L+ +  LH L IVHRDLKPEN+L   LD++  I ++DFG S   +PG  L  
Sbjct: 118 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLST 177

Query: 184 VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM 243
            CGTP Y+APE++          Y K VD WS GVI Y LL G PPF+      +   I+
Sbjct: 178 ACGTPGYVAPEVLA------QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQIL 231

Query: 244 SGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF 287
              Y+F SP WDD SD+ KD +   +   P+ R+T E+AL HP+
Sbjct: 232 KAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275


>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
           isoform 1 [Homo sapiens]
          Length = 666

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
           isoform 4 [Homo sapiens]
          Length = 517

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
           isoform 6 [Homo sapiens]
          Length = 492

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
           isoform 2 [Homo sapiens]
          Length = 542

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
           isoform 7 [Homo sapiens]
          Length = 479

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
           isoform 8 [Homo sapiens]
          Length = 449

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
           isoform 5 [Homo sapiens]
          Length = 503

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  197 bits (500), Expect = 2e-50
 Identities = 114/317 (35%), Positives = 172/317 (54%), Gaps = 29/317 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + Y+  E +G+G  SVVRRC+   T  EYA K+I+       S  + ++L     +E 
Sbjct: 10  FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTK---KLSARDHQKLE----REA 62

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
            I R +  H NI++L D+     F +LVFDL+  GELF+ +  +   SE +    ++ +L
Sbjct: 63  RICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL 121

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNMN---IKLTDFGFSCQLEPGERLR-EVCGTPSYL 191
           E +   H++ +VHRDLKPEN+LL        +KL DFG + +++  ++      GTP YL
Sbjct: 122 EAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYL 181

Query: 192 APEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGS 251
           +PE++          YGK VD+W+ GVI+Y LL G PPFW   Q  + + I +G Y F S
Sbjct: 182 SPEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 235

Query: 252 PEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF-----------FQQYLVEEVRHFS 300
           PEWD  +   K+L+++ L + P  R TA EAL HP+            +Q  VE ++ F+
Sbjct: 236 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFN 295

Query: 301 PRGKFKVIALTVLASVR 317
            R K K   LT + + R
Sbjct: 296 ARRKLKGAILTTMLATR 312


>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
           sapiens]
          Length = 473

 Score =  196 bits (499), Expect = 2e-50
 Identities = 120/313 (38%), Positives = 173/313 (55%), Gaps = 33/313 (10%)

Query: 20  YEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILR 79
           +E +  LGRG +S+V RC  K T + YA+KV+  T             ++    E+ +L 
Sbjct: 46  FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVD-----------KKIVRTEIGVLL 94

Query: 80  KVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVIC 139
           ++S HPNII+LK+ +ET T   LV +L+  GELFD + EK   SE++    ++ +LE + 
Sbjct: 95  RLS-HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVA 153

Query: 140 TLHKLNIVHRDLKPENILL---DDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEII 196
            LH+  IVHRDLKPEN+L      +  +K+ DFG S  +E    ++ VCGTP Y APEI+
Sbjct: 154 YLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL 213

Query: 197 E-CSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFW-HRKQMLMLRMIMSGNYQFGSPEW 254
             C+       YG EVDMWS G+I Y LL G  PF+  R    M R I++  Y F SP W
Sbjct: 214 RGCA-------YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWW 266

Query: 255 DDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF---------FQQYLVEEVRHFSPRGKF 305
           D+ S   KDLV + +V+ P+ R T  +AL HP+               ++++ F+ R K 
Sbjct: 267 DEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKL 326

Query: 306 KVIALTVLASVRI 318
           K     V+AS R+
Sbjct: 327 KAAVKAVVASSRL 339


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  196 bits (498), Expect = 3e-50
 Identities = 107/279 (38%), Positives = 156/279 (55%), Gaps = 20/279 (7%)

Query: 13  AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATL 72
           A+D  + +E KE LG G  S V     K T + +AVK I         P++  + +E+++
Sbjct: 16  AEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCI---------PKKALKGKESSI 66

Query: 73  K-EVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIM 131
           + E+ +LRK+  H NI+ L+D YE+    +LV  L+  GELFD + EK   +EK+   ++
Sbjct: 67  ENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125

Query: 132 RALLEVICTLHKLNIVHRDLKPENILL---DDNMNIKLTDFGFSCQLEPGERLREVCGTP 188
           R +L+ +  LH++ IVHRDLKPEN+L    D+   I ++DFG S     G+ +   CGTP
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP 185

Query: 189 SYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQ 248
            Y+APE++          Y K VD WS GVI Y LL G PPF+      +   I+   Y+
Sbjct: 186 GYVAPEVLA------QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYE 239

Query: 249 FGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF 287
           F SP WDD SD+ KD +   +   P  RYT E+A  HP+
Sbjct: 240 FDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 278


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  196 bits (498), Expect = 3e-50
 Identities = 107/279 (38%), Positives = 156/279 (55%), Gaps = 20/279 (7%)

Query: 13  AQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATL 72
           A+D  + +E KE LG G  S V     K T + +AVK I         P++  + +E+++
Sbjct: 16  AEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCI---------PKKALKGKESSI 66

Query: 73  K-EVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIM 131
           + E+ +LRK+  H NI+ L+D YE+    +LV  L+  GELFD + EK   +EK+   ++
Sbjct: 67  ENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125

Query: 132 RALLEVICTLHKLNIVHRDLKPENILL---DDNMNIKLTDFGFSCQLEPGERLREVCGTP 188
           R +L+ +  LH++ IVHRDLKPEN+L    D+   I ++DFG S     G+ +   CGTP
Sbjct: 126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP 185

Query: 189 SYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQ 248
            Y+APE++          Y K VD WS GVI Y LL G PPF+      +   I+   Y+
Sbjct: 186 GYVAPEVLA------QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYE 239

Query: 249 FGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF 287
           F SP WDD SD+ KD +   +   P  RYT E+A  HP+
Sbjct: 240 FDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 278


>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
          Length = 454

 Score =  186 bits (473), Expect = 2e-47
 Identities = 110/288 (38%), Positives = 158/288 (54%), Gaps = 14/288 (4%)

Query: 14  QDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLK 73
           +D  ++YE  E LG G  ++VR+C  K T +EYA K I        S       RE   +
Sbjct: 7   EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKR---RLSSSRRGVSREEIER 63

Query: 74  EVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRA 133
           EV+ILR++  HPNII L D +E  T   L+ +L+  GELFD+L EK +L+E E  + ++ 
Sbjct: 64  EVNILREIR-HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQ 122

Query: 134 LLEVICTLHKLNIVHRDLKPENILLDD----NMNIKLTDFGFSCQLEPGERLREVCGTPS 189
           +L+ +  LH   I H DLKPENI+L D    N  IKL DFG + ++E G   + + GTP 
Sbjct: 123 ILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPE 182

Query: 190 YLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQF 249
           ++APEI+      ++   G E DMWS GVI Y LL+G+ PF    +   L  I + NY F
Sbjct: 183 FVAPEIV------NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDF 236

Query: 250 GSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVR 297
               + + S+  KD + R LV  P+ R T  ++L H + +      VR
Sbjct: 237 DEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVR 284


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  186 bits (473), Expect = 2e-47
 Identities = 107/280 (38%), Positives = 152/280 (54%), Gaps = 27/280 (9%)

Query: 16  FYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEV 75
           F + YE KE +G G  SV +RC+HK T  EYAVK+ID +             +    +E+
Sbjct: 419 FTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKS-------------KRDPSEEI 465

Query: 76  DILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALL 135
           +IL +   HPNII LKD Y+   F +LV +LM+ GEL D +  +   SE+E   ++  + 
Sbjct: 466 EILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTIT 525

Query: 136 EVICTLHKLNIVHRDLKPENILLDDNM----NIKLTDFGFSCQLEPGE-RLREVCGTPSY 190
           + +  LH   +VHRDLKP NIL  D      +I++ DFGF+ QL  G   L   C T ++
Sbjct: 526 KTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANF 585

Query: 191 LAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQML---MLRMIMSGNY 247
           +APE+++        GY    D+WS G+++YT+LAG  PF +        +L  I SG Y
Sbjct: 586 VAPEVLK------RQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKY 639

Query: 248 QFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPF 287
                 WD  SD  KD+VS+ L V P  R TA + L HP+
Sbjct: 640 ALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPW 679



 Score =  134 bits (336), Expect = 2e-31
 Identities = 93/293 (31%), Positives = 156/293 (53%), Gaps = 32/293 (10%)

Query: 10  SHSAQDFYENYEPKE-----ILGRGVSS---VVRRCIHKPTSQEYAVKVIDVTGGGSFSP 61
           SH  ++ +E  +P +     +LG+G      +VR+       Q YA+KV+        + 
Sbjct: 52  SHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKK------AT 105

Query: 62  EEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVT 121
            +VR+ R  +  E DIL +V+ HP I++L   ++T    +L+ D ++ G+LF  L+++V 
Sbjct: 106 LKVRD-RVRSKMERDILAEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM 163

Query: 122 LSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQ-LEPGER 180
            +E++ +  +  L   +  LH L I++RDLKPENILLD+  +IK+TDFG S + ++  +R
Sbjct: 164 FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKR 223

Query: 181 LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR 240
               CGT  Y+APE++      +  G+ +  D WS GV+M+ +L GS PF  + +   + 
Sbjct: 224 AYSFCGTIEYMAPEVV------NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA 277

Query: 241 MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTA-----EEALAHPFF 288
           +I+    + G P++   S   + L+       P NR  A     EE   HPFF
Sbjct: 278 LILKA--KLGMPQF--LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF 326


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,051,753
Number of Sequences: 37866
Number of extensions: 684255
Number of successful extensions: 3714
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 1290
Number of HSP's gapped (non-prelim): 990
length of query: 387
length of database: 18,247,518
effective HSP length: 104
effective length of query: 283
effective length of database: 14,309,454
effective search space: 4049575482
effective search space used: 4049575482
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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