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Search of human proteins with 51871374
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein,
homolog C [Homo sapiens]
(766 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein, homolog... 1495 0.0
gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein, homolog... 1349 0.0
gi|221219020 NYD-SP11 protein [Homo sapiens] 80 7e-15
gi|71061468 centromere protein E [Homo sapiens] 67 6e-11
gi|104526627 triadin [Homo sapiens] 66 1e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 65 2e-10
gi|148746195 trichohyalin [Homo sapiens] 65 3e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 5e-10
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 63 1e-09
gi|45439327 periplakin [Homo sapiens] 63 1e-09
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 62 2e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 62 2e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 61 3e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 6e-09
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 60 8e-09
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 60 8e-09
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 60 8e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 59 2e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 59 2e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 59 2e-08
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 59 2e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 58 3e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 57 6e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 57 6e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 6e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 57 6e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 57 6e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 57 6e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 57 6e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 57 6e-08
>gi|51871374 UTP14, U3 small nucleolar ribonucleoprotein, homolog C
[Homo sapiens]
Length = 766
Score = 1495 bits (3870), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 1 MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKL 60
MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKL
Sbjct: 1 MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKL 60
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN
Sbjct: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
Query: 121 KEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKAR 180
KEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKAR
Sbjct: 121 KEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKAR 180
Query: 181 TPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKA 240
TPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKA
Sbjct: 181 TPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKA 240
Query: 241 RKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQN 300
RKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQN
Sbjct: 241 RKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQN 300
Query: 301 SGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVA 360
SGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVA
Sbjct: 301 SGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVA 360
Query: 361 NEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLR 420
NEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLR
Sbjct: 361 NEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLR 420
Query: 421 EFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEG 480
EFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEG
Sbjct: 421 EFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEG 480
Query: 481 TVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTP 540
TVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTP
Sbjct: 481 TVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTP 540
Query: 541 NNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAG 600
NNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAG
Sbjct: 541 NNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAG 600
Query: 601 DDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKD 660
DDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKD
Sbjct: 601 DDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKD 660
Query: 661 KNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKV 720
KNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKV
Sbjct: 661 KNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKV 720
Query: 721 VTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL 766
VTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL
Sbjct: 721 VTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL 766
>gi|21361348 UTP14, U3 small nucleolar ribonucleoprotein, homolog A
[Homo sapiens]
Length = 771
Score = 1349 bits (3492), Expect = 0.0
Identities = 692/767 (90%), Positives = 729/767 (95%), Gaps = 3/767 (0%)
Query: 1 MNVNQVAENL-ALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRK 59
M N++AE+L ALS QEEL DLPK+Y LSE+EDEGD+DGERKHQKLLEAI SLDGKNRRK
Sbjct: 1 MTANRLAESLLALSQQEELADLPKDYLLSESEDEGDNDGERKHQKLLEAISSLDGKNRRK 60
Query: 60 LAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPL 119
LAERSEASLKVSEF+VSSEGSGEKL LADLLEPVKTSSSLATVKKQL+RVKSKK VELPL
Sbjct: 61 LAERSEASLKVSEFNVSSEGSGEKLVLADLLEPVKTSSSLATVKKQLSRVKSKKTVELPL 120
Query: 120 NKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKA 179
NKE+IE+IHREVAF+KT+QVLSKWDP++LKN+QAEQLVFPL KE+PAIAPIEH LSGWKA
Sbjct: 121 NKEEIERIHREVAFNKTAQVLSKWDPVVLKNRQAEQLVFPLEKEEPAIAPIEHVLSGWKA 180
Query: 180 RTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAK 239
RTPLEQEIFNLLHKNKQPVTDPLLTP+EKASL+AMSLEEAKM RAELQRARALQSYYEAK
Sbjct: 181 RTPLEQEIFNLLHKNKQPVTDPLLTPVEKASLRAMSLEEAKMRRAELQRARALQSYYEAK 240
Query: 240 ARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQ 299
AR+EKKIKSKKYHKVVKKGKAKKALKEFEQL+KVNP ALEE+EKIE ARMMERMSLKHQ
Sbjct: 241 ARREKKIKSKKYHKVVKKGKAKKALKEFEQLRKVNPAAALEELEKIEKARMMERMSLKHQ 300
Query: 300 NSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTE-VEELLVPH 358
NSGKWAKSKAIMAKYDLEARQAMQEQL+KNKELTQKLQVASESEEEEGGTE VEELLVP
Sbjct: 301 NSGKWAKSKAIMAKYDLEARQAMQEQLSKNKELTQKLQVASESEEEEGGTEDVEELLVPD 360
Query: 359 VANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEIL 418
V NEVQMN DGPNPWM RSCTSDTKEAATQEDPEQ+PEL AH VS SE EERPVAEEEIL
Sbjct: 361 VVNEVQMNADGPNPWMLRSCTSDTKEAATQEDPEQLPELEAHGVSESEGEERPVAEEEIL 420
Query: 419 LREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASS 478
LREFEER+SLRKRSEL+QDAEPA SQETKDS SQEVLSELR LSQKLKE HQSRKQKASS
Sbjct: 421 LREFEERRSLRKRSELSQDAEPAGSQETKDSGSQEVLSELRVLSQKLKENHQSRKQKASS 480
Query: 479 EGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSER 538
EGT+PQVQREEPAPEE EPLLLQR ERVQTLEELEELGKE+CFQNKELPRPVLEGQQSER
Sbjct: 481 EGTIPQVQREEPAPEEEEPLLLQRPERVQTLEELEELGKEECFQNKELPRPVLEGQQSER 540
Query: 539 TPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAF 598
TPNNRPDAPKEKK+KEQ+I+LQN LTTQSPSV+SLAVPT IEELEDEEER+ RQMIKEAF
Sbjct: 541 TPNNRPDAPKEKKKKEQMIDLQNLLTTQSPSVKSLAVPT-IEELEDEEERNHRQMIKEAF 599
Query: 599 AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPR 658
AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRR+FLIKAPEGPPR
Sbjct: 600 AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRRFLIKAPEGPPR 659
Query: 659 KDKNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTP 718
KDKNLPNVII+EKRNIHAAAHQV+VLPYPFTHH QFERTIQTPIGSTWNTQRAFQKLTTP
Sbjct: 660 KDKNLPNVIINEKRNIHAAAHQVRVLPYPFTHHWQFERTIQTPIGSTWNTQRAFQKLTTP 719
Query: 719 KVVTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEK 765
KVVTKPGHII PIKAEDVGY+SSSRSDL VIQRNPKRITTRH K+ K
Sbjct: 720 KVVTKPGHIINPIKAEDVGYRSSSRSDLSVIQRNPKRITTRHKKQLK 766
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 80.1 bits (196), Expect = 7e-15
Identities = 111/495 (22%), Positives = 214/495 (43%), Gaps = 74/495 (14%)
Query: 59 KLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELP 118
KL + E +K E +E +KL V+ SLA +++L + K K +E
Sbjct: 1894 KLTQEKETVIKKKEKLAETE---KKL--------VQVEDSLAKKQEKLAQEKMKLALEKA 1942
Query: 119 LNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
+ + K +++ E+ +K + L+ + +K E++ GKE + S +
Sbjct: 1943 MVQGK-KRLRGELDIAKEEKALN----LEMKRLAEEKMRLVEGKETLSKGETPET-SRQR 1996
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEA 238
T +EQE+F + K + + +L ++ +++EE+++ + +L+ R + + +
Sbjct: 1997 KMTQVEQELF----ERKLSLEEKILLHEDRI----LAMEESEIAKGKLEFTRGQRIFVQG 2048
Query: 239 K---ARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEE--MEKIENARMMER 293
+ A+ +K+ K+ + K K LK ++L + + EE M K++ A ++
Sbjct: 2049 QRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKE 2108
Query: 294 MSLKHQNSG----KW---------AKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVAS 340
L + S +W K + +A+ + M+ + K +++T++ +
Sbjct: 2109 RRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLA 2168
Query: 341 ES-------EEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQ 393
+EEEGG E EE+ +P + W R KEA + P+
Sbjct: 2169 RKHSEVILDDEEEGGIEEEEV-IPFLKRR----------WRKR------KEAKRGDKPK- 2210
Query: 394 VPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQE 453
E + +V E+EE E E LL E E+++SL E ++ E +E +E
Sbjct: 2211 --EKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEE 2268
Query: 454 VLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELE 513
E +K EK + K+K E +VQ +E EE E ++ + E ++L + E
Sbjct: 2269 RKEEEEG-EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSE--EETESLSD-E 2324
Query: 514 ELGKEDCFQNKELPR 528
E +E C +E+ R
Sbjct: 2325 EEEEESCSLEEEVDR 2339
Score = 78.2 bits (191), Expect = 3e-14
Identities = 134/642 (20%), Positives = 266/642 (41%), Gaps = 94/642 (14%)
Query: 8 ENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEAS 67
E L+ +EEL+ + + L++++++ + ER +K + I + + KLA++ E
Sbjct: 1766 EETKLAQEEELL-IQEKEKLAQHKEKMPEEEERLGRKREQLI-----EKKMKLAQKRERW 1819
Query: 68 LKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQI 127
+ + +E + + + KK L + K E KEK+ Q
Sbjct: 1820 I-------------------NSMEELTKNKMILYQKKNLAQEKKNLAQE----KEKLAQR 1856
Query: 128 HREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEI 187
+ ++K SK + +KN+ LG +A +E L+ K ++E
Sbjct: 1857 KENLLYNKERLTHSKKQLVQVKNK--------LGMFNKILAQVEEKLTQEKETVIKKKEK 1908
Query: 188 FNLLHKNKQPVTDPLLTPMEKASLQAM--SLEEA-----KMHRAELQRARALQSY-YEAK 239
K V D L EK + + M +LE+A K R EL A+ ++ E K
Sbjct: 1909 LAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMK 1968
Query: 240 ARKEKKIKSKKYHKVVKKGKAKKALKE----------FEQLQKVNPTVALEE-----MEK 284
E+K++ + + + KG+ + ++ FE+ + + L E ME+
Sbjct: 1969 RLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEE 2028
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
E A+ + + + + A ++ ++ R+++ ++ AK ++ + LQ + E
Sbjct: 2029 SEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDER 2088
Query: 345 EEGGTEVE------ELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELA 398
+ E++ L V ++ + W F S+ + T+++ + LA
Sbjct: 2089 KLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDF----SEKRSELTKDEKK----LA 2140
Query: 399 AHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSEL 458
+ + R + +EE + E E + RK SE+ D E E +EV+ L
Sbjct: 2141 RKQRKLANKMRRMINKEEKMTEE--ESKLARKHSEVILDDEEEGGIE-----EEEVIPFL 2193
Query: 459 RALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQ-------RSERVQTLEE 511
+ +K KE + K K V +V+ EE EE E LL + SE + EE
Sbjct: 2194 KRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREE 2253
Query: 512 LEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVR 571
EE +E+ + +E + EG++ + K+K++K++ + + + + +
Sbjct: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
Query: 572 SLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKRE 613
S E L DEEE ++ ++E D ++ LK++++
Sbjct: 2314 S---EEETESLSDEEEEEESCSLEEEV---DREKEILKKEKQ 2349
Score = 56.2 bits (134), Expect = 1e-07
Identities = 83/378 (21%), Positives = 157/378 (41%), Gaps = 53/378 (14%)
Query: 247 KSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAK 306
+++K K K+ K+ L+E E+L + ++ EE E+ ++ KW +
Sbjct: 1473 ETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKL------------KWEE 1520
Query: 307 SKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMN 366
K + ++ + ++ ++Q +E+T + +V+ E EE+E E Q +
Sbjct: 1521 WKQVWE--NMLSSKSKEQQYKDEEEVTLEEEVSREGEEKE-----------QQVTEEQRH 1567
Query: 367 VDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQ 426
+ + W K A ++ Q A E EER +A+EE L + +
Sbjct: 1568 IQEEHKW----ARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKI 1623
Query: 427 SLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLK------EKHQSRKQK-ASSE 479
+ R + + A +ET +++ E L+QK K EK ++K A
Sbjct: 1624 TQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKG 1683
Query: 480 GTVPQV-----QREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQ 534
G + +V Q+ E P+ + L Q E Q LEELE +E ++ +EL + EG+
Sbjct: 1684 GKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE--EGK 1741
Query: 535 QSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMI 594
E K+ E+E+ + Q ++ + + +I+E E + ++
Sbjct: 1742 LVEE--------KKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPE 1793
Query: 595 KEAFAGDDVIRDFLKEKR 612
+E G R+ L EK+
Sbjct: 1794 EEERLGRK--REQLIEKK 1809
Score = 50.4 bits (119), Expect = 6e-06
Identities = 89/453 (19%), Positives = 188/453 (41%), Gaps = 76/453 (16%)
Query: 183 LEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARK 242
LE+E+ + +Q VT+ E+ + + A+ + Q R L E A++
Sbjct: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE 1605
Query: 243 EKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSG 302
E+++ ++ +K + + ++ + + +A Q G
Sbjct: 1606 ERQLAQEE----------RKLAQAYVKITQDDREMA--------------------QAEG 1635
Query: 303 KWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE---EEGG--TEVEELLVP 357
K+A+ + +A+ + Q ++ K K+L +K + + EE ++GG EV+ +L
Sbjct: 1636 KFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQ 1695
Query: 358 HVAN--EVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEE 415
V + + N+D W + + +E + EL+ E ++ EE + EE
Sbjct: 1696 KVEELPQREQNLD----WQEKELAQELEELEW-----DMEELSWKEEELNQ-EEGKLVEE 1745
Query: 416 EILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQK 475
+ L E EE + ++ E S +ETK + +E+L + + + KEK +++
Sbjct: 1746 KKKLAEEEEALAWQR--------EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEER 1797
Query: 476 ASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLE-GQ 534
++ E E+ L +R + ++EEL + K +Q K L + Q
Sbjct: 1798 LG--------RKREQLIEKKMKLAQKRERWINSMEELTK-NKMILYQKKNLAQEKKNLAQ 1848
Query: 535 QSERTPNNRPDAPKEKK----EKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEER-- 588
+ E+ + + K+ K+QL+ ++N L + + + + E+L E+E
Sbjct: 1849 EKEKLAQRKENLLYNKERLTHSKKQLVQVKNKL-----GMFNKILAQVEEKLTQEKETVI 1903
Query: 589 DQRQMIKEAFAGDDVIRDFLKEKREAVEASKPK 621
+++ + E + D L +K+E + K K
Sbjct: 1904 KKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMK 1936
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 67.0 bits (162), Expect = 6e-11
Identities = 141/663 (21%), Positives = 280/663 (42%), Gaps = 78/663 (11%)
Query: 12 LSHQEELVDLPKNYPLSENEDEGDSDGERK---HQKLLEAIISLDGKNRRKL---AERSE 65
L Q+E+V KN+ + + E E +R +KL E L K ++ L E SE
Sbjct: 1094 LKKQQEIVAQEKNHAIKK-EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 66 ASLKVSEF-SVSSEGSGEKLGLADL-LEPVKTSSSLATVKKQLNRVKSKKVVELPLNKE- 122
K++E ++ +E ++L L + E ++ + L +++ + ++ V L K
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 123 KIEQIH-----REVAFS--KTSQVLSKWDPIILKNQQAEQLVFPLGKE-QPAIAPIEHAL 174
+ E+ H RE+ + +T + L K I LK Q + + L + A I +
Sbjct: 1213 ETERDHLRGYIREIEATGLQTKEEL-KIAHIHLKEHQ--ETIDELRRSVSEKTAQIINTQ 1269
Query: 175 SGWKARTPLEQEIFNLLHKNKQPV--------TDPLLTPMEKASLQAMSLEEAKMHRAEL 226
K+ T L++EI +LH+ ++ + T + +E + Q+ + + + R E+
Sbjct: 1270 DLEKSHTKLQEEI-PVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
Query: 227 QRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--ALKEF--EQLQKVNPTVALEEM 282
+R R + + E++ + K + K +K+ K LKE E L K+ + + +E
Sbjct: 1329 ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQ 1388
Query: 283 EKIENARMMERMSLKHQNSGKWAKSKAIMA--------KYDLEARQAMQEQLAKNKELTQ 334
+ E + + K A++ L+ + +AK K+ Q
Sbjct: 1389 SLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448
Query: 335 KLQVASESEEEEGGTEVEELLVPHVANEVQMNV---------DGPNPWMFRSCTSDTKEA 385
+LQ +SE ++ ++E++ H+ E ++ V + N +T+ +
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508
Query: 386 ATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQE 445
Q+ E + + +++ +E EE+ +++ E Q K +EL Q E ++
Sbjct: 1509 TIQKQLEAINDKLQNKI-----QEIYEKEEQFNIKQISEVQ--EKVNELKQFKE---HRK 1558
Query: 446 TKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSER 505
KDS+ Q + S++ L+ +L+E S E ++ +E E L ++R +
Sbjct: 1559 AKDSALQSIESKMLELTNRLQE---------SQEEIQIMIKEKEEMKRVQEALQIERDQL 1609
Query: 506 VQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTT 565
+ +E+ KE Q KE + + + KE+ E ++L NL+N + T
Sbjct: 1610 KENTKEIVAKMKES--QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL-NLEN-IET 1665
Query: 566 QSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEK-REAVEASKPKDVD 624
++ + + + E +ERD + ++E V RD LKE RE + K +
Sbjct: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETL---KVERDQLKENLRETITRDLEKQEE 1722
Query: 625 LTL 627
L +
Sbjct: 1723 LKI 1725
Score = 35.4 bits (80), Expect = 0.20
Identities = 48/230 (20%), Positives = 101/230 (43%), Gaps = 28/230 (12%)
Query: 308 KAIMAKYDLEARQA-MQEQLAKNKELTQKL--QVASESEEEEGGTEVEELL--VPHVANE 362
K ++ +LE + +Q++L K E + L +V SE + +EVE L + + E
Sbjct: 710 KDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE 769
Query: 363 VQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREF 422
+ + + +++ E+ + + A S ++ ++ + L +F
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829
Query: 423 EERQS--LRKRSELNQDAEPASSQETKDSSS------------QEVLSELRALSQKLKEK 468
E++ L + +NQ+ S + K SS QE+ + R + ++L E
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889
Query: 469 HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKE 518
Q ++Q + + T+ V+RE + L+ ++ + QTLEE++ L +E
Sbjct: 890 EQLKEQLENRDSTLQTVERE-------KTLITEKLQ--QTLEEVKTLTQE 930
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 66.2 bits (160), Expect = 1e-10
Identities = 87/403 (21%), Positives = 173/403 (42%), Gaps = 63/403 (15%)
Query: 216 LEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE--------- 266
++E + + E+ + + E + + E+KI++K HK +KGK K KE
Sbjct: 133 IDEPPLRKKEIHKDKT-----EKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187
Query: 267 --FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQE 324
E+ +K +E +K + A E + K GK K K AK + +Q+
Sbjct: 188 EKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKV-----KEVQK 242
Query: 325 QLAKNKELTQKLQVA-SESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTK 383
+K KE K + A S+ E+++ ++ V +++ G +P + +
Sbjct: 243 TPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLK---PGQSPAIPPPLPT--- 296
Query: 384 EAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELN-----QDA 438
E A++ P P L E +AE++ +E + +E++ ++K+SE +
Sbjct: 297 EQASRPTPAS-PALEEKEGEKKKAEKKVTSE-----TKKKEKEDIKKKSEKETAIDVEKK 350
Query: 439 EPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPL 498
EP + ETK + V +A ++K ++K S+K K +E P+ +++E + EP
Sbjct: 351 EPGKASETKQGT---VKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
Query: 499 LLQRSE---------RVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKE 549
+ E + +T EE+G + + G++ E+T ++
Sbjct: 408 KSPKKEHSVPSDKQVKAKTERAKEEIGAVSI-------KKAVPGKKEEKTTK----TVEQ 456
Query: 550 KKEKEQLINLQNFLTTQSP-SVRSLAVPTIIEELEDEEERDQR 591
+ KE+ + L + P + VP ++E E E ++D++
Sbjct: 457 EIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEK 499
Score = 49.7 bits (117), Expect = 1e-05
Identities = 103/544 (18%), Positives = 212/544 (38%), Gaps = 42/544 (7%)
Query: 29 ENEDEGDSD---GERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLG 85
E +D+GD D GE L + I K++ + E+ E ++ E EK+
Sbjct: 119 EEDDDGDEDTDKGEIDEPPLRKKEIH---KDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175
Query: 86 LADLLEPVKT-SSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWD 144
+ E T + +K + +K+ + ++ E+ +EV K +V
Sbjct: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAA 235
Query: 145 PIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLT 204
+ + + KE+ A++ E R ++ + L + P P L
Sbjct: 236 KVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL- 294
Query: 205 PMEKASLQAMSLEEAKMHRAELQRA-RALQSYYEAKARKEKKIKSKKYHKV-VKKGKAKK 262
P E+AS + + E ++A + + S + K +++ K KS+K + V+K + K
Sbjct: 295 PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGK 354
Query: 263 ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSK---AIMAKYDLEAR 319
A + + K+ A ++ EK E+++ ++ + Q GK + K AK +
Sbjct: 355 ASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEH 414
Query: 320 QAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCT 379
++ K K K ++ + S ++ + EE V E++ G
Sbjct: 415 SVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSG---------- 464
Query: 380 SDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAE 439
K ++ +D E + +V AS E+ P +++ K S+ ++ +
Sbjct: 465 ---KTSSILKDKEPIKG-KEEKVPASLKEKEPETKKD------------EKMSKAGKEVK 508
Query: 440 PASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQK-ASSEGTVPQVQREEPAPEEAEPL 498
P Q + + + EK Q KQ E TV + EE ++ + +
Sbjct: 509 PKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAV 568
Query: 499 LLQRSERVQTLEELEELGKEDCFQNKELPRPVLEG--QQSERTPNNRPDAPKEKKEKEQL 556
++++ + + ++ E +E + P+P +G + +E + KE KEK +
Sbjct: 569 TIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADM 628
Query: 557 INLQ 560
+L+
Sbjct: 629 KHLR 632
Score = 33.5 bits (75), Expect = 0.76
Identities = 35/181 (19%), Positives = 74/181 (40%), Gaps = 31/181 (17%)
Query: 375 FRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSEL 434
F S SD + +ED + + E +E P+ ++EI + +
Sbjct: 106 FFSLLSDIISSEDEEDDD-----GDEDTDKGEIDEPPLRKKEI------------HKDKT 148
Query: 435 NQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEE 494
+ +P +TK + ++ + + ++ EK + K+K ++E+P +
Sbjct: 149 EKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIE--------KKEKPETK- 199
Query: 495 AEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKE 554
L + ++ +T E+ EE K++ K+ V + + P PKEK++KE
Sbjct: 200 ---TLAKEQKKAKTAEKSEEKTKKEVKGGKQ--EKVKQTAAKVKEVQKTPSKPKEKEDKE 254
Query: 555 Q 555
+
Sbjct: 255 K 255
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 65.5 bits (158), Expect = 2e-10
Identities = 84/470 (17%), Positives = 199/470 (42%), Gaps = 51/470 (10%)
Query: 100 ATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFP 159
A ++++L V+S+K E+ LN ++++ R++ +K ++L QQ +
Sbjct: 224 AKLQEKLQLVESEKS-EIQLN---VKELKRKLERAK----------LLLPQQQLQAEADH 269
Query: 160 LGKE-QPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEE 218
LGKE Q A ++ + + L Q+ + + ++ + + E+ E+
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 219 AKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVK----KGKAKKALKEFEQLQKVN 274
+ +++R + E K R+++++ +K K+ + + ++ ++E E+
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 275 PTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQ 334
+ +E ++ E ++ E+ + Q + W + + I E + ++EQ K +
Sbjct: 390 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR-----EQEEKIREQEKKMWRQEE 444
Query: 335 KLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQV 394
K+ + EEE E EE+ W + +E Q++
Sbjct: 445 KIHEQEKIREEEKRQEQEEM------------------WRQEEKIREQEEIWRQKEKMHE 486
Query: 395 PELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEV 454
E + +E + ++E +RE EE+ R+ ++ + E QE K +E+
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM-WRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 455 LSE----LRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLE 510
+ E + +K++E+ + R+Q+ +++ ++ E E + ++ E+++ E
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQE 605
Query: 511 ELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQ 560
E+ + +E ++ +E E Q + R +E+K EQ + L+
Sbjct: 606 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR----QEEKMWEQEVRLR 651
Score = 46.2 bits (108), Expect = 1e-04
Identities = 65/284 (22%), Positives = 121/284 (42%), Gaps = 35/284 (12%)
Query: 217 EEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPT 276
+EAKM R E ++ R E K R+++K ++ K+ ++ K ++ K EQ +
Sbjct: 414 QEAKMWRQE-EKIRE----QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 468
Query: 277 VALEEMEKI--ENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQ 334
+ E E+I + +M E+ ++ Q W + + + +D E + QE+ +E
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKM---HDQEEKIREQEEKMWRQEEKI 525
Query: 335 KLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQV 394
+ Q E+EE E EE++ E + + M +E +E E++
Sbjct: 526 REQEEKIREQEEKIREQEEMM-----QEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKI 580
Query: 395 PELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEV 454
E + E EE+ +E+ + +R++ E+ Q+ QE K +E
Sbjct: 581 RE---QKEKIREQEEKI----------WEQEEKIREQEEMMQE------QEEKMWEQEEK 621
Query: 455 LSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPL 498
+ E Q+ +EK R+++ E V Q+EE E E L
Sbjct: 622 MCEQEEKMQEQEEK-MRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 40.0 bits (92), Expect = 0.008
Identities = 61/302 (20%), Positives = 125/302 (41%), Gaps = 26/302 (8%)
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNP 372
K D + +E+ A + EL + E +E+ + + LV +E+Q+NV
Sbjct: 190 KADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKR 249
Query: 373 WMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEIL---LREFEERQSLR 429
+ R+ K Q+ + + E+ + A+ + EE L L + +E + R
Sbjct: 250 KLERA-----KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 304
Query: 430 KRSELNQDAEPASSQETKDSSSQEVLSE----LRALSQKLKEKHQS-RKQKASSEGTVPQ 484
+ ++ + E QE K +E + E +R + + EK + R+Q+ +
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364
Query: 485 VQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRP 544
++R E E E + + E++ E++ E +E+ Q +E R + Q+ E +
Sbjct: 365 MRRLEEMMWEKEEKIRELEEKMHEQEKIRE--QEEKRQEEEKIREQEKRQEQEAKMWRQE 422
Query: 545 DAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVI 604
+ +E++EK + + I E E E ++RQ +E + ++ I
Sbjct: 423 EKIREQEEK-----------IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 471
Query: 605 RD 606
R+
Sbjct: 472 RE 473
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 64.7 bits (156), Expect = 3e-10
Identities = 86/485 (17%), Positives = 201/485 (41%), Gaps = 46/485 (9%)
Query: 212 QAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQ 271
Q +E + RAE ++ ++ + + + E++++ ++ ++ +KG+ +K + E+
Sbjct: 176 QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 272 KV-----------NPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQ 320
+V TV +E EK++ + L+ + + K + + + + +
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE-QLRKLERQELRRERQEEE 294
Query: 321 AMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTS 380
Q++L + ++L +K + ++EE + E E Q+ R
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR---------REQEE 345
Query: 381 DTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEER--QSLRKRSELNQDA 438
++ +E E+ E E E+ + E+ L RE + R Q LR+ +L ++
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 439 EPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQRE---------- 488
+ Q+ + Q++ E + ++ +E+H+ + ++ E + + Q E
Sbjct: 406 QLRREQQLR--REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 489 -EPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAP 547
E +E L+R + + E +L +E+ + +E L +Q ER R
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR-EQRLKRQ 522
Query: 548 KEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIR-- 605
+E++ +Q + + L + R + E+ ++E R+QR ++ D +++
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 606 ------DFLKEKREAVEAS-KPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPR 658
+E+ E +E K ++V+ + + ++RRQ L+K+ E R
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 659 KDKNL 663
+ + L
Sbjct: 643 RQQQL 647
Score = 59.7 bits (143), Expect = 1e-08
Identities = 117/621 (18%), Positives = 236/621 (38%), Gaps = 93/621 (14%)
Query: 27 LSENEDEGDSDGERKHQKLL--------EAIISLDGKNRRKLAERSEASLKVSEFSVSSE 78
L E+ + ER+ Q+L E + L+ + RR+ ER E L+ + +
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 79 GSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQ 138
+ L + +++ L +++ K+ E L +E+ EQ + + Q
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 139 VLSKWDPII---LKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNK 195
+L + + LK +Q E+L L +E+ +E + L++E
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREE-----VERLEQEERREQRLKRE--------- 623
Query: 196 QPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVV 255
P E+ Q + EE + R + R E + R+E+++K ++
Sbjct: 624 --------EPEEERRQQLLKSEEQEERRQQQLRR-------EQQERREQRLKREE----- 663
Query: 256 KKGKAKKALKEFEQLQKVNPTVALEEMEKIENA--RMMERMSLKHQNSGKWAKSKAIMAK 313
++ + ++ LK + ++ +A EE E+ + + + ++ +SK
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 314 YDLEARQAMQEQLAKNKELTQKLQVASES-------EEEEGGTEVEELLVPHVANEVQMN 366
E ++ QEQ K + +LQ E EEE+ + + +
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 367 VDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQ 426
+ P + E Q + +PE E + ER E+E+ E EE+
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER---EKELQFLEEEEQL 840
Query: 427 SLRKRSE--------LNQDAEPASSQE-----------------------TKDSSSQEVL 455
R+R++ L +D E SQE K + +++
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 456 SELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEEL 515
E + L ++ +E + ++K + Q + EE +E E LL + E+ + E +
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 516 GKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAV 575
K+ Q KE L G++ E+ R + K+ +E+E+L + L + R
Sbjct: 961 RKDKKLQQKE---EQLLGEEPEK--RRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 576 PTIIEELEDEEERDQRQMIKE 596
+DE ++++ Q+++E
Sbjct: 1016 WERQYRKKDELQQEEEQLLRE 1036
Score = 58.2 bits (139), Expect = 3e-08
Identities = 88/433 (20%), Positives = 180/433 (41%), Gaps = 55/433 (12%)
Query: 212 QAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVV------KKGKAKKALK 265
+ + EE ++ R E ++ R + E + RK+KK++ K+ + ++ + +K +
Sbjct: 934 EQLQQEEEQLLREEREKRRRQER--ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 266 EFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQ 325
E E+LQ+ + EE EK + +W + + E Q ++E+
Sbjct: 992 EEEELQQEEEQLLREEREK--------------RRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 326 LAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEA 385
K + ++ Q EEEE E E+LL + ++ +R KE
Sbjct: 1038 REKRRLQERERQYR---EEEELQQEEEQLLGEERETRRRQELER----QYR------KEE 1084
Query: 386 ATQEDPEQV----PELAAHEVSASEA--EERPVAEEEILLREFEE---RQSLRKRSELNQ 436
Q++ EQ+ PE + + EE EEE LLRE E RQ L ++ +
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 437 DAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAE 496
+ + Q ++ + EL ++ +E Q +Q E + +RE EE E
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 497 PLLLQRSERVQTLEELEEL------GKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEK 550
+R +R + ++ +L KE+ ++ ++ E +Q + +++ + +
Sbjct: 1205 LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ 1264
Query: 551 KEKEQLINLQNFLTTQSP----SVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRD 606
++ + L+ Q + R P E+LE EE+++ ++ +++ ++R+
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRRDRKSQEEKQLLRE 1323
Query: 607 FLKEKREAVEASK 619
+EKR E +
Sbjct: 1324 EREEKRRRQETDR 1336
Score = 57.8 bits (138), Expect = 4e-08
Identities = 86/362 (23%), Positives = 153/362 (42%), Gaps = 52/362 (14%)
Query: 217 EEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPT 276
EE K R L ALQ + RKE+++ ++ ++ ++ + K+ +E E+ +
Sbjct: 880 EERKRRRHTLYAKPALQE----QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935
Query: 277 VALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKL 336
+ EE + + R R + + ++ K K + K + Q + E+ K + ++
Sbjct: 936 LQQEEEQLLREEREKRR---RQERERQYRKDKKLQQKEE----QLLGEEPEKRRRQEREK 988
Query: 337 QVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPE 396
+ EEEE E E+LL E + + + K+ QE+ + + E
Sbjct: 989 KYR---EEEELQQEEEQLL--REEREKRRRQEWERQYR-------KKDELQQEEEQLLRE 1036
Query: 397 LAAHEVSASEAEERPVAEEEILLREFEE----------RQSL----RKRSELNQDAEPAS 442
E + ER EEE L +E E+ RQ L RK EL Q+ E
Sbjct: 1037 --EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL 1094
Query: 443 SQETKDSSSQEVLSELRALSQKLKEKHQ---SRKQKASSEGTVPQVQREEPAPEEAEPLL 499
+E + QE + R + +E+ Q ++K + Q + EE +E E LL
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 500 LQRSE--RVQTLE----ELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEK 553
+ E R Q LE E EEL +E+ ++L R E ++ ER R + +++++
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEE----EQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 554 EQ 555
+Q
Sbjct: 1211 KQ 1212
Score = 54.7 bits (130), Expect = 3e-07
Identities = 107/570 (18%), Positives = 232/570 (40%), Gaps = 84/570 (14%)
Query: 103 KKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGK 162
+K+ + + KK E +++ EQ+ RE + Q +W+ K + +Q L +
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ---EWERQYRKKDELQQEEEQLLR 1035
Query: 163 EQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMH 222
E+ ++ ++ L+QE LL + ++ L + + + EE ++
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE-EELQQEEEQLL 1094
Query: 223 RAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEM 282
R E ++ R + E + R+E++++ ++ +++++ + K+ +E E+ + V EE
Sbjct: 1095 REEPEKRRRQER--ERQCREEEELQQEE-EQLLREEREKRRRQELERQYREEEEVQQEEE 1151
Query: 283 EKIENA---RMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVA 339
+ + R + + +++ + + + + + + E R+ +E+ + +E Q+ +
Sbjct: 1152 QLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 340 SESEEEEGGTEVEELLVPHVANEVQMN---VDGPNPWMFRSCT-SDTKEAATQED----- 390
+E+ ++++ P N V+ N G FR S ++ +Q+D
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 391 ----------------------PEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSL 428
PE+ +L E ++ +R EE+ LLR EER+
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLR--EEREEK 1328
Query: 429 RKRSELN------------QDAEPASSQETKDSSSQEVL-----------SELRALSQKL 465
R+R E + ++ +P QE +E L E R Q+
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER 1388
Query: 466 KEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKE 525
+ K +Q+ + Q++++ E L R ER + E +E + +E
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE-----EEQQVRRQE 1443
Query: 526 LPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELED- 584
R LE +Q R +R + +E+EQL+ + + R +EE +
Sbjct: 1444 RERKFLEEEQQLRQERHR-----KFREEEQLLQERE----EQQLHRQERDRKFLEEEQQL 1494
Query: 585 -EEERDQRQMIKEAFAGDDVIRDFLKEKRE 613
+ERD R+ ++ + R FL+E+++
Sbjct: 1495 RRQERD-RKFREQELRSQEPERKFLEEEQQ 1523
Score = 54.3 bits (129), Expect = 4e-07
Identities = 120/608 (19%), Positives = 242/608 (39%), Gaps = 78/608 (12%)
Query: 15 QEELVDLPKNYPLSENEDEGDS-DGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEF 73
QE+ +L + SE ++ + D +R+ ++L + R+ E S K E
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 74 SVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAF 133
+ E+L +LLE + K+Q R + +V + +E+ E RE
Sbjct: 202 EEFPDE--EQLRRRELLELRRKGRE---EKQQQRRERQDRVFQ---EEEEKEWRKRETVL 253
Query: 134 SKTSQVLSKWDP--------------------IILKNQQAEQLVFPLGKEQPAIAPIEHA 173
K + L + +P + + Q+ EQ L +EQ E
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 174 LSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQ 233
+ +QE + ++ L E+ Q + E+ + R + R +
Sbjct: 314 RREQQEERREQQERREQQEERRE---QQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 234 SYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMER 293
E + R+E++++ ++ + ++ + ++ L+ +QL++ + E+ + E E+
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQ 429
Query: 294 MSLKHQNSGKWAKSKAIMAKYDLEARQAM--QEQLAKNKELTQKLQVASESEEE--EGGT 349
+H+ + + + + + E R + +E+ ++++ +K Q+ + EEE E
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 350 EVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEE 409
++EE R + +E + + E+ E E +
Sbjct: 490 KLEE--------------------EERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 410 RPVAEEEILLREFEE-RQSLRKRSELNQDAEPASSQETKDSSSQEVLSELR-ALSQKLKE 467
+ + E+ L RE EE R+ L KR E E QE ++ + E R L ++ +E
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREE-----EKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 468 KHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELP 527
+ Q R ++ E +++REE E E QR +R EE EE ++ +++E
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR----EEPEEERRQQLLKSEE-- 638
Query: 528 RPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE 587
+ QQ R R + +++E+E+ L+ L + R +EL +EE+
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEE--RLEQRLKREHEEERR------EQELAEEEQ 690
Query: 588 RDQRQMIK 595
R+ IK
Sbjct: 691 EQARERIK 698
Score = 51.6 bits (122), Expect = 3e-06
Identities = 75/380 (19%), Positives = 161/380 (42%), Gaps = 31/380 (8%)
Query: 217 EEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPT 276
EE ++ R E R R + + R+E++ K + + +++ + +K +E EQL +
Sbjct: 1419 EEQQLSRQE--RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK-FREEEQLLQEREE 1475
Query: 277 VALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKL 336
L E+ + + E L+ Q + + + + ++ ++QL + + + L
Sbjct: 1476 QQLHRQER-DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 337 QVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPE 396
Q + +E G + + E Q+ + ++ ++++ ++
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE------------EQQLSRQERDRKFR 1582
Query: 397 LAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLS 456
L +V E +ER E+E LR E +Q LR+ + + QE ++
Sbjct: 1583 LEEQKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 457 ELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELG 516
+ + L ++ + + Q R+Q+ + + + EE +E E L+R ER + E
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRD-RKFREEEQLLQEGEEQQLRRQERDRKFRE----- 1695
Query: 517 KEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVP 576
+E + +E R L+ +Q R R + ++ +E+EQL T Q R
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLR----RQELERKFREEEQL----RQETEQEQLRRQERYR 1747
Query: 577 TIIEELEDEEERDQRQMIKE 596
I+EE + ER+++Q+ ++
Sbjct: 1748 KILEEEQLRPEREEQQLRRQ 1767
Score = 48.1 bits (113), Expect = 3e-05
Identities = 113/605 (18%), Positives = 241/605 (39%), Gaps = 74/605 (12%)
Query: 8 ENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLA----ER 63
E L ++ L + P+ E E + + E + ++ E ++ + + RR+ R
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE--EQLLREEREKRRRQELERQYR 1141
Query: 64 SEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKV--------- 114
E ++ E + E EK +L + L ++QL R + +K
Sbjct: 1142 EEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 115 VELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHAL 174
E L ++K +Q +R+ + S + +W+P +N + V+ G+E +E
Sbjct: 1201 EEEELQRQKRKQRYRDE--DQRSDLKWQWEPE-KENAVRDNKVYCKGRENEQFRQLED-- 1255
Query: 175 SGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSL---EEAKMHRAELQRARA 231
S + R +Q++ +LL + ++ + E+ Q EE ++ R E + A+
Sbjct: 1256 SQLRDRQS-QQDLQHLLGEQQERDRE-----QERRRWQQRDRHFPEEEQLEREEQKEAKR 1309
Query: 232 LQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMM 291
+ K+++EK++ ++ + ++ + + +E EQL + L E+ R
Sbjct: 1310 R----DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365
Query: 292 ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEV 351
E L+HQ G+ K+ LE Q ++ Q + K L ++ Q+ + E++
Sbjct: 1366 E---LRHQEQGR---------KF-LEEEQRLRRQERERKFLKEEQQLRCQEREQQ----- 1407
Query: 352 EELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERP 411
++ + D + + ++ +E+ +QV + ER
Sbjct: 1408 -----------LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR---------QERERK 1447
Query: 412 VAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQS 471
EEE LR+ R+ + L + E ++ +D E +LR + K + Q
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 472 RKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVL 531
+ + + + Q+ + + L ++ R Q + ++ F+ +E R
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 532 EGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQR 591
E QQ R +R +E+K + Q + F+ + R + +E D + R+
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQ-EQERKFMEDEQQLRRQEGQQQLRQE-RDRKFREDE 1625
Query: 592 QMIKE 596
Q+++E
Sbjct: 1626 QLLQE 1630
Score = 44.3 bits (103), Expect = 4e-04
Identities = 70/346 (20%), Positives = 143/346 (41%), Gaps = 41/346 (11%)
Query: 216 LEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNP 275
LEE K+ R E +R + ++ E + R+++ + + + K + ++ L+E E+ Q
Sbjct: 1583 LEEQKVRRQEQER-KFMED--EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 276 TVALEEMEKIENARMMER-MSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQ 334
+ +E+ R ER L+H K+ + + ++ + + Q ++ Q K +
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGE---EQQLRRQERDRKFREE 1696
Query: 335 KLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQV 394
+ Q+ + E + E ++L + + + + ++ + + EQ+
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFR----------------EEEQLRQETEQEQL 1740
Query: 395 PELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEV 454
+ E + RP EE+ L R+ +R+ R+ +L Q+ E Q+ + S
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRK-FREEEQLRQERE---EQQLRSQESDRK 1796
Query: 455 LSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEE 514
E L Q+ +E+ Q R Q QR+ E E L L+ E+ E +
Sbjct: 1797 FREEEQLRQE-REEQQLRPQ-----------QRDGKYRWEEEQLQLEEQEQRLRQERDRQ 1844
Query: 515 LGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQ 560
E+ F +E R E Q+ + + +E+K +E+ I Q
Sbjct: 1845 YRAEEQFATQEKSR--REEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Score = 41.2 bits (95), Expect = 0.004
Identities = 66/291 (22%), Positives = 122/291 (41%), Gaps = 43/291 (14%)
Query: 217 EEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPT 276
EE ++HR E R + L+ E + R++++ + ++ + K + ++ L+E E+ Q
Sbjct: 1632 EEQQLHRQERDR-KFLEE--EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ----- 1683
Query: 277 VALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKE---LT 333
L E+ R E+ + + K+ + + + + +LE + +EQL + E L
Sbjct: 1684 --LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 334 QKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGP-----NPWMFRSCTSDTK----E 384
++ + EEE+ E EE + + + + RS SD K E
Sbjct: 1742 RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 385 AATQEDPEQVPELAAHEVSAS---EAEERPVAEEEILLREFEERQ------------SLR 429
QE EQ +L + E E+ + E+E LR+ +RQ S R
Sbjct: 1802 QLRQEREEQ--QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 430 KRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEG 480
+ EL Q+ E QE + +E + QK +++H+ + S EG
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRR----QQKEEQRHRQVGEIKSQEG 1906
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/227 (22%), Positives = 90/227 (39%), Gaps = 24/227 (10%)
Query: 380 SDTKEAATQEDPEQVPE-LAAHEVSASEAEERPVAEEEIL------LREFEERQSLRKRS 432
S+ +E Q D ++ E L E EER EE++ EF + + LR+R
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 433 ELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAP 492
L + ++ + Q+ + + + K + RK++ + PQ QRE
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 493 EEAEPLLLQ---RSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKE 549
EE L + R ER + ++ + L +E + K+ QQ ER +E
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ--EEERREQQEERREQQERREQQE 332
Query: 550 KKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKE 596
++ ++QL Q Q E EEER ++Q+ +E
Sbjct: 333 ERREQQLRREQEERREQQ------------LRREQEEERREQQLRRE 367
Score = 38.5 bits (88), Expect = 0.024
Identities = 53/270 (19%), Positives = 109/270 (40%), Gaps = 26/270 (9%)
Query: 420 REFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSE 479
R EE Q + + + EP + K + L+E S+K + Q +Q+ E
Sbjct: 113 RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE 172
Query: 480 GTVPQVQREEPAPEEAEPLLLQRSERVQTLE-------------ELEELGKEDCFQNKEL 526
+ + +E AE LQ + +T E EL G+E+ Q +
Sbjct: 173 LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE 232
Query: 527 PRPVLEGQQSERTPNNRPDAPKEKKEK--EQLINLQNFLTTQSPSVRSLAVPTIIEELED 584
+ + ++ E+ R ++++EK E+ Q L + +R L + E ++
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292
Query: 585 EEERDQRQMIKEAF--AGDDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSA 642
EE++ QR ++ ++ R+ +E+RE E + ++ E L+
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE---------ERREQQLRREQ 343
Query: 643 KKRRQFLIKAPEGPPRKDKNLPNVIISEKR 672
++RR+ ++ + R+++ L E+R
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERR 373
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 63.9 bits (154), Expect = 5e-10
Identities = 106/470 (22%), Positives = 187/470 (39%), Gaps = 48/470 (10%)
Query: 28 SENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVS-----SEGSGE 82
S ++E S E K + ++ + K+ + +A V E + S S E
Sbjct: 566 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE 625
Query: 83 KLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSK 142
A++ P K S K + KS + E ++ + E + ++
Sbjct: 626 AKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK---- 681
Query: 143 WDPIILKNQQAEQLVFPLGKE----QPAIAPI-EHALSGWKARTPLEQEIFNLLHKNKQP 197
P+ + + E+ P+ +E + A +P+ E A S KA++P+++E K K P
Sbjct: 682 -SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA-KTPEKAKSP 739
Query: 198 VTDPLLTPM-----EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYH 252
V + +P EKA + EAK E R+ A + +AK+ ++++KS +
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 253 K-------------VVKKGKAKKALKEFEQLQKVN----PTVALEEMEKIENARMMERMS 295
K + KK + K +KE E+ Q+V P A EE ++ S
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS 859
Query: 296 LKHQNSGKWAKSKAIMAKYDLEARQAMQEQL-AKNKELTQKLQVASESEEEEGGTEVEEL 354
K + K A + K + + + ++ AK +E K +V + +E EV+E
Sbjct: 860 KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 355 LVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAE 414
P EV S ++ KEAA ++ + E A + EE+P E
Sbjct: 920 AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK-------EEKAKKPEEKPKTE 972
Query: 415 EEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQK 464
+ +E ++ S + AE +SS + KDS E +E +A K
Sbjct: 973 AK--AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 42.7 bits (99), Expect = 0.001
Identities = 85/431 (19%), Positives = 162/431 (37%), Gaps = 51/431 (11%)
Query: 232 LQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMM 291
LQS + R ++ ++ K + + ++ + QLQ T LE ++ +++
Sbjct: 287 LQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQA--RTTELEALKSTKDSLER 344
Query: 292 ERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGG--- 348
+R L+ ++ A + + + D E R E A+ +E L V + E
Sbjct: 345 QRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRK 404
Query: 349 -TEVEELLV----------------PHVANEVQMNVDGPNPWMFRS---------CTSDT 382
E EE + P V+ +++ + + +S T +T
Sbjct: 405 LLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEET 464
Query: 383 K--EAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRK------RSEL 434
+ E T+E+ ++ E E E EE EEE EE S K + E
Sbjct: 465 QVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA 524
Query: 435 NQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEE 494
AE S ++ + S EV S +A S KE+ +S + S E + E +PE+
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKS-PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 495 AEPLLLQRSE---RVQTLEELEELGKEDCFQNKELPRPVLEGQQSE---RTPNNRPDAPK 548
A+ + ++ ++ E+ + KE+ E PV E +S ++P K
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK 643
Query: 549 EKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFL 608
E+ + + +SP V + E + + +K + + +
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPV-----KAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
Query: 609 KEKREAVEASK 619
KE+ ++ E +K
Sbjct: 699 KEEAKSPEKAK 709
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 62.8 bits (151), Expect = 1e-09
Identities = 125/622 (20%), Positives = 258/622 (41%), Gaps = 67/622 (10%)
Query: 16 EELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLK--VSEF 73
+E+ +L + E E + R+ LE ++ +L E + ASL+ V E
Sbjct: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVK-----ELQLKEDARASLERLVKEM 452
Query: 74 SVSSEGSGEKLGLADLL-----EPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIH 128
+ E K AD L E + +SS +L R K ++ E L ++++ +
Sbjct: 453 APLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLT 512
Query: 129 REVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIF 188
R++ F +T Q+ + +Q +QL+ + +E P+ E
Sbjct: 513 RQLQFLET-QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGE-- 569
Query: 189 NLLHKNKQ--PVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKI 246
KN+ PV L K + L+EA++ ++Q + +A EK++
Sbjct: 570 ----KNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKEL 625
Query: 247 KSKKYHKVVKKGKAKKALKEFEQLQKVNPTV--ALEEMEKIENARMMERMSLKHQNSGKW 304
++ + +GK + +++ LQ+ + +L +E E+ S++H
Sbjct: 626 QNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLE-------AEQASIRHLGDQME 678
Query: 305 AKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQ 364
A A+ +A++AM+ Q+A+ + + Q + E E ++ EVE+ A +
Sbjct: 679 ASLLAVR-----KAKEAMKAQMAEKEAILQ----SKEGECQQLREEVEQCQQLAEARHRE 729
Query: 365 MNVDGPNPWMFRSCTSDTK--EAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREF 422
+ + C T+ E T E +Q + A + +++ ++ + +
Sbjct: 730 LRA------LESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQG 783
Query: 423 E----ERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASS 478
E + Q + ++++ + +++ S ++ VL E + L Q+LKE++++ +A
Sbjct: 784 EVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEA-LNRAHV 842
Query: 479 EGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSER 538
+ + +RE EE QR E ++ L+ EEL + C ++E E Q+
Sbjct: 843 QELLQCSEREGALQEERADEAQQREEELRALQ--EELSQAKC-SSEEAQLEHAELQEQLH 899
Query: 539 TPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE--RDQRQMIKE 596
N + +L LT + V A+ ++EL+D +E +R+ ++
Sbjct: 900 RANT---------DTAELGIQVCALTVEKERVEE-ALACAVQELQDAKEAASREREGLER 949
Query: 597 AFAGDDVIRDFLKEKREAVEAS 618
AG ++ L+EK +A +A+
Sbjct: 950 QVAGLQQEKESLQEKLKAAKAA 971
Score = 39.3 bits (90), Expect = 0.014
Identities = 101/522 (19%), Positives = 195/522 (37%), Gaps = 63/522 (12%)
Query: 151 QQAEQLVFPLGKEQPAIAPI-----EHALS--GWKARTPLEQEIFNLLHKNKQPVTDPLL 203
++ E ++ PL +E A +H S GW A + + + ++P+
Sbjct: 338 RRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAA 397
Query: 204 TPMEK--ASLQAMSLEEAKMHRAELQRA-------RALQSYYEAKARKEKKIKSKKYHKV 254
M++ LQA+ E K+ Q++ + LQ +A+A E+ +K +
Sbjct: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE 457
Query: 255 VKKGKAKKALKEFEQLQKVNPTVALEEME----KIENARMMERMSLKHQNSGKWAKSKAI 310
GK ++A + + +LQ++ + E E + E + E L Q +
Sbjct: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQF 517
Query: 311 MAKYDLEARQAMQEQLAKNKELTQKLQVASESE---EEEGGTEVEELLVPHVANE--VQM 365
+ + Q + + + K+L Q S+ E G EL V NE V +
Sbjct: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
Query: 366 NVDGPNPW---------MFRSCTSDTK--EAATQEDPEQVPELAAHE----VSASEAEER 410
N W + + DTK E + +E+ Q E V ++ E
Sbjct: 578 NSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEG 637
Query: 411 PVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQ 470
+ + + ++R+S + S + +AE AS + D +L+ +A + +
Sbjct: 638 KLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAE 697
Query: 471 SRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPV 530
S EG Q++ E E+ + L R ++ LE C Q +L +
Sbjct: 698 KEAILQSKEGECQQLREE---VEQCQQLAEARHRELRALE-------SQCQQQTQLIEVL 747
Query: 531 L--EGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEE------L 582
+GQQ P + + ++ QL Q L V+ L + + L
Sbjct: 748 TAEKGQQGVGPPTDN----EARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAAL 803
Query: 583 EDEEE-RDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDV 623
+D+++ + Q M + + LKE+ EA+ + +++
Sbjct: 804 DDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
Score = 35.8 bits (81), Expect = 0.15
Identities = 73/325 (22%), Positives = 141/325 (43%), Gaps = 54/325 (16%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
E+ S S EEA++ AELQ + + A ++ + V+K + ++AL
Sbjct: 875 EELSQAKCSSEEAQLEHAELQ-----EQLHRANT-DTAELGIQVCALTVEKERVEEAL-- 926
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQA----- 321
A++E++ + A ER L+ Q +G + +++ K L+A +A
Sbjct: 927 ---------ACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEK--LKAAKAAAGSL 975
Query: 322 --MQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCT 379
+Q QLA+ ++ Q LQ A+ +E T +L + + ++ G C
Sbjct: 976 PGLQAQLAQAEQRAQSLQEAA---HQELNTLKFQLSAEIMDYQSRLKNAG------EECK 1026
Query: 380 SDTKEAATQEDPEQVPELAAHEVSASEAE--------ERPVAE-EEILLREFEERQSLRK 430
S + Q Q E A ++ A++A+ +AE + +LR+ +E +LR+
Sbjct: 1027 SLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALRE 1086
Query: 431 RSELNQ-DAEPASS--QETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQR 487
E Q + E A++ QE + QEV + R + L + + K E + ++ R
Sbjct: 1087 DLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLR 1146
Query: 488 EEPAPEEAEPLLLQRSERVQTLEEL 512
++ A L Q+S+ ++ ++L
Sbjct: 1147 DKDA-------LWQKSDALEFQQKL 1164
Score = 33.9 bits (76), Expect = 0.58
Identities = 46/182 (25%), Positives = 73/182 (40%), Gaps = 38/182 (20%)
Query: 441 ASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQK----ASSEGTVPQVQ---------- 486
A +E ++ + + S L+ L+Q+L+ S +K AS G + Q
Sbjct: 327 AEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTK 386
Query: 487 -REEPAPEEAEPLLLQRSERVQTLE---------------ELEELGKEDCFQNKELPRPV 530
R+EP P +A + + E++Q LE +LE+L KE Q KE R
Sbjct: 387 GRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKE--LQLKEDARAS 444
Query: 531 LEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQ 590
LE E P + K ++ + LQ L S LA EL E+++ Q
Sbjct: 445 LERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELA------ELRREKKQQQ 498
Query: 591 RQ 592
+
Sbjct: 499 EE 500
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 62.8 bits (151), Expect = 1e-09
Identities = 99/495 (20%), Positives = 216/495 (43%), Gaps = 84/495 (16%)
Query: 44 KLLEAIISLDGKNRRKLAERSEASL---KVSEFSVSSEGSGEKLGLADLLEPVKTSSSLA 100
++L+ L+ R+K A +E L +V+ + + EK+ ++++ ++ L
Sbjct: 1009 EVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLE 1067
Query: 101 TVKKQL-------NRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQA 153
+QL ++++ K+ EL ++K++++ +E A ++ ++ K + K+
Sbjct: 1068 AEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAE-GKITVKEVLKVEKDAAT 1126
Query: 154 EQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPM------- 206
E+ V L ++ A A + + +T L ++I+ L +N + V + +
Sbjct: 1127 EREVSDLTRQYEDEAA--KARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKA 1184
Query: 207 --EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKAL 264
E A+L+ +E+ + +R ++ R+ QS EA R+ +++ K+ K V K K +
Sbjct: 1185 ESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEM 1244
Query: 265 -KEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQ 323
KE ++L++ E ++ R++ER L+ K +++A + +
Sbjct: 1245 EKELQRLRE----------EIVDKTRLIERCDLE-----------IYQLKKEIQALKDTK 1283
Query: 324 EQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTK 383
Q+ + + + LQ + + +E + L +V + +
Sbjct: 1284 PQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLE----------------R 1327
Query: 384 EAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASS 443
E A+QE+ ++A E S +ER V +E + +EE LR AE ++
Sbjct: 1328 ERASQEE-----QIARKEEELSRVKERVVQQEVV---RYEEEPGLR--------AEASAF 1371
Query: 444 QETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRS 503
E+ D ELR + + E + ++++ E + +++RE A EAE + +
Sbjct: 1372 AESIDV-------ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQ 1424
Query: 504 ERVQTLEELEELGKE 518
+R+ LE+ E +E
Sbjct: 1425 QRLAALEQEEAEARE 1439
Score = 47.4 bits (111), Expect = 5e-05
Identities = 95/473 (20%), Positives = 191/473 (40%), Gaps = 80/473 (16%)
Query: 15 QEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFS 74
+ E+ DL + Y E+E +R+ +LL I +L+ +N + + + + +
Sbjct: 1127 EREVSDLTRQY---EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPK 1183
Query: 75 VSSEGSGEKLGLADLLEPVK-TSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAF 133
SE + +L L + + L + + +L ++ + + +++++ +EV
Sbjct: 1184 AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGP------QVEVKEVTKEVIK 1237
Query: 134 SKTSQVLSKW-----DPIILKNQQAEQL---VFPLGKEQPAIAPIEHALSGWKARTPLEQ 185
KT + K + I+ K + E+ ++ L KE AL K + ++
Sbjct: 1238 YKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEI-------QALKDTKPQVQTKE 1290
Query: 186 EIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEK- 244
+ +L + P T E ASL+A EE K + +L+R RA Q E ARKE+
Sbjct: 1291 VVQEILQFQEDPQTKE-----EVASLRAKLSEEQKK-QVDLERERASQE--EQIARKEEE 1342
Query: 245 --KIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIE-NARMMERMSLKHQNS 301
++K + + V + + + L+ + V L +++K+ R ++R + +
Sbjct: 1343 LSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQ 1402
Query: 302 GKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVAN 361
+ + + E RQA +E + + L Q+L A E EE E +V
Sbjct: 1403 ---------LEELERE-RQARREAEREVQRLQQRL-AALEQEEAEAREKV---------- 1441
Query: 362 EVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLRE 421
+ T++ Q+DP+Q E A + E + R ++L E
Sbjct: 1442 ------------------THTQKVVLQQDPQQAREHALLRLQLEEEQHR----RQLLEGE 1479
Query: 422 FEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQ 474
E + E + E E+ + E++ L L+E+ +S+++
Sbjct: 1480 LETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 62.0 bits (149), Expect = 2e-09
Identities = 97/440 (22%), Positives = 183/440 (41%), Gaps = 56/440 (12%)
Query: 112 KKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQ-LVFPLGKEQPAIAPI 170
+++ E P+ +++ +Q+ +++ + + ++ L+ ++ Q L+ KEQ +A +
Sbjct: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQL 386
Query: 171 EHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRAR 230
E A K R EQE L KQ L ++ + +E + + EL+R R
Sbjct: 387 ERAEQERKERERQEQERKRQLELEKQLEKQREL-ERQREEERRKEIERREAAKRELERQR 445
Query: 231 ALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARM 290
L+ +E R+E + K + + KAKK EFE L+ +N
Sbjct: 446 QLE--WERNRRQELLNQRNKEQEDIVVLKAKKKTLEFE-LEALN---------------- 486
Query: 291 MERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTE 350
KHQ GK + + E + + + E+T Q ES++ G
Sbjct: 487 ----DKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLI 542
Query: 351 VEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEER 410
E+ ++ +VQ N + + + KE A Q +Q+ E+ + + S+ +E
Sbjct: 543 PEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEV--EKETRSKLQEI 600
Query: 411 PVAEEEIL-LREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ ++ LRE +Q L+K+ + + QE K + EL +K KE+
Sbjct: 601 DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERK-------IIEL----EKQKEEA 649
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEEL-----EELGKEDC---- 520
Q R Q+ + + VQ+E+ E P L E+++ E + EE GK++
Sbjct: 650 QRRAQERDKQ-WLEHVQQED---EHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKL 705
Query: 521 ----FQNKELPRPVLEGQQS 536
Q++E +P ++ S
Sbjct: 706 GRLFHQHQEPAKPAVQAPWS 725
Score = 32.3 bits (72), Expect = 1.7
Identities = 33/157 (21%), Positives = 68/157 (43%), Gaps = 14/157 (8%)
Query: 402 VSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRAL 461
+S++ ++R + EE +L +E+Q L K+ P + ++ K + + EL
Sbjct: 320 ISSTSVDQR-LPEEPVLE---DEQQQLEKKL-------PVTFEDKKRENFERGNLELEKR 368
Query: 462 SQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQ---RSERVQTLEELEELGKE 518
Q L E+ + +++ + Q ++E E+ L+ + E+ + LE E +
Sbjct: 369 RQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERR 428
Query: 519 DCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQ 555
+ +E + LE Q+ NR ++ KEQ
Sbjct: 429 KEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQ 465
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 62.0 bits (149), Expect = 2e-09
Identities = 97/440 (22%), Positives = 183/440 (41%), Gaps = 56/440 (12%)
Query: 112 KKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQ-LVFPLGKEQPAIAPI 170
+++ E P+ +++ +Q+ +++ + + ++ L+ ++ Q L+ KEQ +A +
Sbjct: 327 QRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQL 386
Query: 171 EHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRAR 230
E A K R EQE L KQ L ++ + +E + + EL+R R
Sbjct: 387 ERAEQERKERERQEQERKRQLELEKQLEKQREL-ERQREEERRKEIERREAAKRELERQR 445
Query: 231 ALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARM 290
L+ +E R+E + K + + KAKK EFE L+ +N
Sbjct: 446 QLE--WERNRRQELLNQRNKEQEDIVVLKAKKKTLEFE-LEALN---------------- 486
Query: 291 MERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTE 350
KHQ GK + + E + + + E+T Q ES++ G
Sbjct: 487 ----DKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLI 542
Query: 351 VEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEER 410
E+ ++ +VQ N + + + KE A Q +Q+ E+ + + S+ +E
Sbjct: 543 PEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEV--EKETRSKLQEI 600
Query: 411 PVAEEEIL-LREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ ++ LRE +Q L+K+ + + QE K + EL +K KE+
Sbjct: 601 DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERK-------IIEL----EKQKEEA 649
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEEL-----EELGKEDC---- 520
Q R Q+ + + VQ+E+ E P L E+++ E + EE GK++
Sbjct: 650 QRRAQERDKQ-WLEHVQQED---EHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKL 705
Query: 521 ----FQNKELPRPVLEGQQS 536
Q++E +P ++ S
Sbjct: 706 GRLFHQHQEPAKPAVQAPWS 725
Score = 32.3 bits (72), Expect = 1.7
Identities = 33/157 (21%), Positives = 68/157 (43%), Gaps = 14/157 (8%)
Query: 402 VSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRAL 461
+S++ ++R + EE +L +E+Q L K+ P + ++ K + + EL
Sbjct: 320 ISSTSVDQR-LPEEPVLE---DEQQQLEKKL-------PVTFEDKKRENFERGNLELEKR 368
Query: 462 SQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQ---RSERVQTLEELEELGKE 518
Q L E+ + +++ + Q ++E E+ L+ + E+ + LE E +
Sbjct: 369 RQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERR 428
Query: 519 DCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQ 555
+ +E + LE Q+ NR ++ KEQ
Sbjct: 429 KEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQ 465
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 61.2 bits (147), Expect = 3e-09
Identities = 150/711 (21%), Positives = 289/711 (40%), Gaps = 111/711 (15%)
Query: 4 NQVAENLALSHQEELVDLPKNYPLSENEDEGDSD--------GERKHQKLLEAIISLDGK 55
NQ+ +N Q + DL + +E+EG E K +K+ E I+ L+ +
Sbjct: 938 NQILQNEKKKMQAHIQDLEEQL----DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 56 NRRKLAERSEASLKVSEFSVSSEGSGEK------------LGLADLLEPVK----TSSSL 99
N + + E+ +++E S EK + ++DL E +K T L
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 100 ATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQ--VLSKWDPIILKNQQAEQLV 157
K++L+ + ++ + +I+++ ++A + L++ D L A ++V
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 158 FPLGKEQPAIAPIEHALSGWKA-RTPLEQEIFNL---LHKNKQPVTDPLLTP-------- 205
L Q IA ++ KA R E++ +L L K + D L T
Sbjct: 1114 REL---QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 206 ---MEKASLQAMSLEEAKMHRAELQ-----RARALQSYYE----AKARKEKKIKSKK--- 250
E A L+ EE K H A++Q A AL+ E AK K K+K+
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 251 --------YHKVVKKGKAK---KALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQ 299
KV+++ KA+ K K Q+Q+++ V+ + ++E A ++ +
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 300 NSG-----------KWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGG 348
N K+AK A + + ++ +QE+ + L+ +++ E +
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 349 TEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTK-----EAATQEDPEQVPE--LAAHE 401
+ EE E + N++ +S +DTK + T E E+ + L E
Sbjct: 1351 QQEEE-------EEARKNLE-KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 402 VSASEAEERPVAEEEILLREFEERQSLRKRS-ELNQDAEPASSQETKDSSSQEVLSELRA 460
+ EE+ +A +++ + +Q L + +L+ + AS+ E K ++L+E ++
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 461 LSQKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKE 518
+S + E+ + +A + T + + E A E E Q + +E+L K+
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS-SKD 1521
Query: 519 DCFQNK---ELPRPVLEGQQSE-RTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLA 574
D +N E + LE Q E RT + + E +L N ++ R L
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL- 1580
Query: 575 VPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVDL 625
+ +++ E +R +IK+ + + D K++ AV + K ++DL
Sbjct: 1581 -----QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626
Score = 53.9 bits (128), Expect = 5e-07
Identities = 113/542 (20%), Positives = 216/542 (39%), Gaps = 69/542 (12%)
Query: 11 ALSHQEELVDLPKNYP--LSENEDEGDSDGERK--HQKLLEAIISLDGKNRRKL-AERSE 65
AL E ++ K + L +N+ ++D + K+L+ + + R+KL A+ E
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 66 ASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSK--KVVELPLNKEK 123
KVSE G++L + + K + L V L + K K + + E
Sbjct: 1264 LHAKVSE--------GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315
Query: 124 IEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPL 183
Q +E+ +T Q L+ I ++ L +E+ +AR L
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE-------------EARKNL 1362
Query: 184 EQEIFNL---LHKNKQPVTDPLLT--PMEKASLQAMSLEEAKMHRAELQRARALQSYYEA 238
E+++ L L K+ V D L T +E+A + + EA R E ++A A +
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE-EKALAYDKLEKT 1421
Query: 239 KARKEKKIKSKKY---HKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
K R ++++ H+ +K K+F+QL +++ E+ + A R
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481
Query: 296 LKHQNSGKWAKSKAIMAKY-----------DLEARQAMQEQLAKNKELTQKLQVASESEE 344
S A +A+ AK D+E + ++ + KN +K + A E +
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Query: 345 EEGGTEVEELLVPHVANE-----VQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAA 399
EE T++EEL A E +++N+ R + E E+ L
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT------RDEQNEEKKRLLI 1595
Query: 400 HEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQ-ETKDSSSQEVLSEL 458
+V EAE ++ L ++ + ++ D + +Q E + + EV+ +L
Sbjct: 1596 KQVRELEAELEDERKQRAL--------AVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 459 RALSQKLKE-KHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGK 517
R L ++K+ + + + +AS + Q + E + E +LQ E + + E +
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 518 ED 519
++
Sbjct: 1708 QE 1709
Score = 47.0 bits (110), Expect = 7e-05
Identities = 109/549 (19%), Positives = 230/549 (41%), Gaps = 93/549 (16%)
Query: 16 EELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSV 75
EEL+ + + E E E + ERKHQ+LLE KN ++E L +
Sbjct: 859 EELLKVKEKQTKVEGELE---EMERKHQQLLEE------KNILAEQLQAETELFAEAEEM 909
Query: 76 SSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKV------VELPLNKE------- 122
+ + +K L ++L +++ + Q+ + + KK+ +E L++E
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 123 KIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTP 182
++E++ E K + + ++L++Q ++ + KE+ +E ++ ++
Sbjct: 970 QLEKVTAEAKIKKMEEEI-----LLLEDQNSKFI-----KEKKL---MEDRIAECSSQLA 1016
Query: 183 LEQEIFNLLHK--NKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRAR-----ALQSY 235
E+E L K NKQ V +++ +E+ L++ + R EL++A+
Sbjct: 1017 EEEEKAKNLAKIRNKQEV---MISDLEE------RLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALK--EFEQLQKVNPTVALEEMEKIENARMMER 293
+ A + +I K K+ + + AL + E L K N + E++ + A + E
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ-AQIAELQED 1126
Query: 294 MSLKHQNSGKWAKSKAIMAKY----------DLEARQAMQEQLAKNKELTQKLQVASESE 343
+ + K K K +++ L+ A QE K ++ +L+ A E E
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 344 EEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVS 403
+ +++++ H +++ F++ K+ ++ E E+ +
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 404 ASEAEER-------------PVAEEEILLREFEERQS-----LRKRSELNQDAEPASSQE 445
+E+E + V+E + L E E+ S L S L ++AE +
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 446 TKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSER 505
KD++S E S+L+ + L+E+ +QK + + Q++ E+ + +E Q+ E
Sbjct: 1307 AKDAASLE--SQLQDTQELLQEE---TRQKLNLSSRIRQLEEEKNSLQE------QQEEE 1355
Query: 506 VQTLEELEE 514
+ + LE+
Sbjct: 1356 EEARKNLEK 1364
Score = 44.7 bits (104), Expect = 3e-04
Identities = 84/379 (22%), Positives = 164/379 (43%), Gaps = 61/379 (16%)
Query: 268 EQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLA 327
E+L KV E+ K+E +E M KHQ + + K I+A E QA E A
Sbjct: 859 EELLKVK-----EKQTKVEGE--LEEMERKHQ---QLLEEKNILA----EQLQAETELFA 904
Query: 328 KNKELTQKLQVASESEEE-----EGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDT 382
+ +E+ +L + EE E E EE + NE + ++ D
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK---------MQAHIQDL 955
Query: 383 KEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPAS 442
+E +E+ + +L +V+A EA+ + + EEEILL E + + ++++ + S
Sbjct: 956 EEQLDEEEGAR-QKLQLEKVTA-EAKIKKM-EEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 443 SQETKDSSSQEVLSELR--------ALSQKLKEKHQSR------KQKASSEGTVPQVQRE 488
SQ ++ + L+++R L ++LK++ ++R K+K E T Q Q
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 489 EPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQN-------KELPRPVLEGQ---QSER 538
E + + L LQ +++ + L+ G ++ +EL + E Q +SE+
Sbjct: 1073 E-LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 539 TPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAF 598
N+ EK++++ L+ T ++ + A + ++E + ++ ++E
Sbjct: 1132 ASRNK----AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 599 AGDDV-IRDFLKEKREAVE 616
+ I+D + A+E
Sbjct: 1188 KNHEAQIQDMRQRHATALE 1206
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 60.5 bits (145), Expect = 6e-09
Identities = 107/570 (18%), Positives = 224/570 (39%), Gaps = 58/570 (10%)
Query: 43 QKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLAT- 101
++L E L K + +E+SE L V E KL A LL P + + A
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELK-------RKLERAKLLLPQQQLQAEADH 269
Query: 102 VKKQLNRVKSKKVVELPLNK--EKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFP 159
+ K+L V +K ++ N+ ++ Q E + + ++ +W+ I + ++ +
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI-QEWEEKIQEQEEKIREQEE 328
Query: 160 LGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLE-- 217
+EQ + + K QE + K + ++ E+ + +
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 218 --------EAKMHRAELQRARALQSYYEAKARKEKKIKS--KKYHKVVKKGKAKKALKEF 267
E KMH E R + E K ++E+KI+ K+ + K + ++ ++E
Sbjct: 389 KEEKIRELEEKMHEQEKIREQ------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 442
Query: 268 EQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDL-EARQAMQEQL 326
E+ + + EKI + + + W + + I + ++ ++ M EQ
Sbjct: 443 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQE 502
Query: 327 AKNKELTQKLQVASES--EEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKE 384
K ++ +K+ E E+EE E EE + W + +E
Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIREQEEKM-----------------WRQEEKIREQEE 545
Query: 385 AATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQ 444
+E+ E E E E++ +EE +RE EE+ R+ ++ + E Q
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE-KIREQEEKV-WRQEEKIREQEEKRQEQ 603
Query: 445 ETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSE 504
E K +E + E Q+ +EK + +++K + + Q Q E+ +E + E
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK-----MCE 658
Query: 505 RVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEK--KEKEQLINLQNF 562
+ + ++E EE + +E + + E ++ R +EK +++E++ +
Sbjct: 659 QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 563 LTTQSPSVRSLAVPTIIEELEDEEERDQRQ 592
+ Q +R +E+ ++ ++ Q
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 54.7 bits (130), Expect = 3e-07
Identities = 96/527 (18%), Positives = 220/527 (41%), Gaps = 66/527 (12%)
Query: 121 KEKIEQIHREVAFS-KTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKA 179
++ I ++H F+ + Q LS + + ++A++ + L KE+ A LS
Sbjct: 161 RDLISRLHDSWKFAGELEQALSA---VATQKKKADRYIEELTKERDA-------LSLELY 210
Query: 180 RTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLE-EAKMHRAEL----QRARALQS 234
R + E L KN + L EK+ +Q E + K+ RA+L Q+ +A
Sbjct: 211 RNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 235 YY-----EAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEE---MEKIE 286
+ A+ + +++ + + + + +K ++ E++Q+ + +E E+ E
Sbjct: 269 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 328
Query: 287 NARMMERMSLKHQNSGKWAKSKAIMAKYDL----EARQAMQEQLAKNKELTQKLQVASES 342
R E ++ Q W K + + + ++ E + QE++ KE + Q
Sbjct: 329 KIREQEE-KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 387
Query: 343 EEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEV 402
E+EE E+EE + + ++ QE+ Q E +
Sbjct: 388 EKEEKIRELEEKM------------------------HEQEKIREQEEKRQEEEKIREQE 423
Query: 403 SASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
E E + +EE +RE EE+ +++ Q+ + ++ ++ ++ E+
Sbjct: 424 KRQEQEAKMWRQEE-KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 482
Query: 463 QKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQ 522
+K+ E+ + +QK +++++E E + ++ E+++ EE +E +
Sbjct: 483 EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542
Query: 523 NKELPRPVLEGQQSERTPNNRPDAPKEKK---EKEQLINLQNFLTTQSPSVRSLAVPTII 579
+E+ R + + E+ +E K ++E++ + + Q +R
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 580 EE----LEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKD 622
+E ++E+ R+Q + I+E ++ IR+ ++ RE E ++ ++
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQ---EEKIREQEEKIREQEEMTQEQE 646
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 60.1 bits (144), Expect = 8e-09
Identities = 113/563 (20%), Positives = 237/563 (42%), Gaps = 73/563 (12%)
Query: 39 ERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSS 98
E K +K E ++ L+ +N + ER +++EFS + EK+ + L +K ++
Sbjct: 1002 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR-LKYEAT 1060
Query: 99 LATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVF 158
+A ++ +L + + ++++E++ R + ++S++ + ++ + Q+AE+L
Sbjct: 1061 IADMEDRLRKEEK--------GRQELEKLKRRLD-GESSEL---QEQMVEQQQRAEELRA 1108
Query: 159 PLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEE 218
LG++ E L AR E L K+ + L E + ++ +
Sbjct: 1109 QLGRK-------EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161
Query: 219 AKMHRAEL-QRARALQSYYE---AKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVN 274
A+ R +L + AL+ E +++++SK+ +V + KK L+E ++ +
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT---ELKKTLEEETRIHE-- 1216
Query: 275 PTVALEEMEKIEN---ARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQE-QLAKNK 330
A++E+ + + E++ + G W K++ + E R + Q A+ +
Sbjct: 1217 --AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 1274
Query: 331 ELTQKLQVASESEEEEGGTEVEELLVPHVANEVQM------NVDGP-NPWMFRSCTSDTK 383
++ ++ + +E +G E A ++Q NV G N ++ +
Sbjct: 1275 GEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKE 1334
Query: 384 EAATQEDPEQVPELAAHE----------VSASEAEE---RPVAEEEILLREFEERQSLRK 430
++T+ EL E V A EAE R EEE RE R+
Sbjct: 1335 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1394
Query: 431 RSELNQ----DAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQ 486
+++L++ E A + E + + + E AL+Q+L EK ++ + +
Sbjct: 1395 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR------R 1448
Query: 487 REEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNK--------ELPRPVLEGQQSER 538
R + ++A L Q+ + V TLE+ + + + K E R EG++ E
Sbjct: 1449 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1508
Query: 539 TPNNRPDAPKEKKEKEQLINLQN 561
+ A +E++E + + QN
Sbjct: 1509 RALSLTRALEEEQEAREELERQN 1531
Score = 32.3 bits (72), Expect = 1.7
Identities = 54/247 (21%), Positives = 105/247 (42%), Gaps = 24/247 (9%)
Query: 392 EQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSS 451
+++ + +A EV + + EE L E LR +EL +AE +
Sbjct: 890 QELQQQSAREVGELQGRVAQLEEERARLAE-----QLRAEAELCAEAEETRGRLAARKQE 944
Query: 452 QE-VLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQR--SERVQT 508
E V+SEL A ++ E+ + +Q + + + Q +E A EAE Q+ E+V T
Sbjct: 945 LELVVSELEA---RVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTT 1001
Query: 509 LEELEELGKEDCF----QNKEL--PRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNF 562
++++ +ED QN +L R +LE + +E + + K K + + +
Sbjct: 1002 EAKMKKF-EEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1060
Query: 563 LTTQSPSVRS-----LAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEA 617
+ +R + + L+ E Q QM+++ ++ +R L K E ++A
Sbjct: 1061 IADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE-LRAQLGRKEEELQA 1119
Query: 618 SKPKDVD 624
+ + D
Sbjct: 1120 ALARAED 1126
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 60.1 bits (144), Expect = 8e-09
Identities = 113/563 (20%), Positives = 237/563 (42%), Gaps = 73/563 (12%)
Query: 39 ERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSS 98
E K +K E ++ L+ +N + ER +++EFS + EK+ + L +K ++
Sbjct: 994 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR-LKYEAT 1052
Query: 99 LATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVF 158
+A ++ +L + + ++++E++ R + ++S++ + ++ + Q+AE+L
Sbjct: 1053 IADMEDRLRKEEK--------GRQELEKLKRRLD-GESSEL---QEQMVEQQQRAEELRA 1100
Query: 159 PLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEE 218
LG++ E L AR E L K+ + L E + ++ +
Sbjct: 1101 QLGRK-------EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153
Query: 219 AKMHRAEL-QRARALQSYYE---AKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVN 274
A+ R +L + AL+ E +++++SK+ +V + KK L+E ++ +
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT---ELKKTLEEETRIHE-- 1208
Query: 275 PTVALEEMEKIEN---ARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQE-QLAKNK 330
A++E+ + + E++ + G W K++ + E R + Q A+ +
Sbjct: 1209 --AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 1266
Query: 331 ELTQKLQVASESEEEEGGTEVEELLVPHVANEVQM------NVDGP-NPWMFRSCTSDTK 383
++ ++ + +E +G E A ++Q NV G N ++ +
Sbjct: 1267 GEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKE 1326
Query: 384 EAATQEDPEQVPELAAHE----------VSASEAEE---RPVAEEEILLREFEERQSLRK 430
++T+ EL E V A EAE R EEE RE R+
Sbjct: 1327 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1386
Query: 431 RSELNQ----DAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQ 486
+++L++ E A + E + + + E AL+Q+L EK ++ + +
Sbjct: 1387 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR------R 1440
Query: 487 REEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNK--------ELPRPVLEGQQSER 538
R + ++A L Q+ + V TLE+ + + + K E R EG++ E
Sbjct: 1441 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1500
Query: 539 TPNNRPDAPKEKKEKEQLINLQN 561
+ A +E++E + + QN
Sbjct: 1501 RALSLTRALEEEQEAREELERQN 1523
Score = 32.3 bits (72), Expect = 1.7
Identities = 54/247 (21%), Positives = 105/247 (42%), Gaps = 24/247 (9%)
Query: 392 EQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSS 451
+++ + +A EV + + EE L E LR +EL +AE +
Sbjct: 882 QELQQQSAREVGELQGRVAQLEEERARLAE-----QLRAEAELCAEAEETRGRLAARKQE 936
Query: 452 QE-VLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQR--SERVQT 508
E V+SEL A ++ E+ + +Q + + + Q +E A EAE Q+ E+V T
Sbjct: 937 LELVVSELEA---RVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTT 993
Query: 509 LEELEELGKEDCF----QNKEL--PRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNF 562
++++ +ED QN +L R +LE + +E + + K K + + +
Sbjct: 994 EAKMKKF-EEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1052
Query: 563 LTTQSPSVRS-----LAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEA 617
+ +R + + L+ E Q QM+++ ++ +R L K E ++A
Sbjct: 1053 IADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE-LRAQLGRKEEELQA 1111
Query: 618 SKPKDVD 624
+ + D
Sbjct: 1112 ALARAED 1118
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 60.1 bits (144), Expect = 8e-09
Identities = 113/563 (20%), Positives = 237/563 (42%), Gaps = 73/563 (12%)
Query: 39 ERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSS 98
E K +K E ++ L+ +N + ER +++EFS + EK+ + L +K ++
Sbjct: 1035 EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR-LKYEAT 1093
Query: 99 LATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVF 158
+A ++ +L + + ++++E++ R + ++S++ + ++ + Q+AE+L
Sbjct: 1094 IADMEDRLRKEEK--------GRQELEKLKRRLD-GESSEL---QEQMVEQQQRAEELRA 1141
Query: 159 PLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEE 218
LG++ E L AR E L K+ + L E + ++ +
Sbjct: 1142 QLGRK-------EEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194
Query: 219 AKMHRAEL-QRARALQSYYE---AKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVN 274
A+ R +L + AL+ E +++++SK+ +V + KK L+E ++ +
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT---ELKKTLEEETRIHE-- 1249
Query: 275 PTVALEEMEKIEN---ARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQE-QLAKNK 330
A++E+ + + E++ + G W K++ + E R + Q A+ +
Sbjct: 1250 --AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQE 1307
Query: 331 ELTQKLQVASESEEEEGGTEVEELLVPHVANEVQM------NVDGP-NPWMFRSCTSDTK 383
++ ++ + +E +G E A ++Q NV G N ++ +
Sbjct: 1308 GEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKE 1367
Query: 384 EAATQEDPEQVPELAAHE----------VSASEAEE---RPVAEEEILLREFEERQSLRK 430
++T+ EL E V A EAE R EEE RE R+
Sbjct: 1368 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTA 1427
Query: 431 RSELNQ----DAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQ 486
+++L++ E A + E + + + E AL+Q+L EK ++ + +
Sbjct: 1428 QAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGR------R 1481
Query: 487 REEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNK--------ELPRPVLEGQQSER 538
R + ++A L Q+ + V TLE+ + + + K E R EG++ E
Sbjct: 1482 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1541
Query: 539 TPNNRPDAPKEKKEKEQLINLQN 561
+ A +E++E + + QN
Sbjct: 1542 RALSLTRALEEEQEAREELERQN 1564
Score = 32.3 bits (72), Expect = 1.7
Identities = 54/247 (21%), Positives = 105/247 (42%), Gaps = 24/247 (9%)
Query: 392 EQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSS 451
+++ + +A EV + + EE L E LR +EL +AE +
Sbjct: 923 QELQQQSAREVGELQGRVAQLEEERARLAE-----QLRAEAELCAEAEETRGRLAARKQE 977
Query: 452 QE-VLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQR--SERVQT 508
E V+SEL A ++ E+ + +Q + + + Q +E A EAE Q+ E+V T
Sbjct: 978 LELVVSELEA---RVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTT 1034
Query: 509 LEELEELGKEDCF----QNKEL--PRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNF 562
++++ +ED QN +L R +LE + +E + + K K + + +
Sbjct: 1035 EAKMKKF-EEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1093
Query: 563 LTTQSPSVRS-----LAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEA 617
+ +R + + L+ E Q QM+++ ++ +R L K E ++A
Sbjct: 1094 IADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE-LRAQLGRKEEELQA 1152
Query: 618 SKPKDVD 624
+ + D
Sbjct: 1153 ALARAED 1159
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/476 (18%), Positives = 200/476 (42%), Gaps = 68/476 (14%)
Query: 100 ATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFP 159
A ++++L V+S+K E+ LN ++++ R++ +K ++L QQ +
Sbjct: 285 AKLQEKLQLVESEKS-EIQLN---VKELKRKLERAK----------LLLPQQQLQAEADH 330
Query: 160 LGKE-QPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEE 218
LGKE Q A ++ + + L Q+ + + ++ + + E+ E+
Sbjct: 331 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 390
Query: 219 AKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKA----KKALKEFEQLQKVN 274
+ +++R + E K R+++++ +K K+ ++ + ++ ++E E+
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 275 PTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQ 334
+ +E ++ E ++ E+ + Q + W + + I E + ++EQ K +
Sbjct: 451 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR-----EQEEKIREQEEKMWRQEE 505
Query: 335 KLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQV 394
K+ + EEE E EE+ W +E +
Sbjct: 506 KIHEQEKIREEEKRQEQEEM------------------WR------------QEEKIREQ 535
Query: 395 PELAAHEVSASEAEERPVAEEEILLREFE----ERQSLRKRSE-LNQDAEPASSQETKDS 449
E+ + E EE+ +EE + R+ E + + +R++ E + + E QE K
Sbjct: 536 EEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIR 595
Query: 450 SSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQ-----REEPAPEEAEPLLLQRSE 504
+E + E ++Q+ +EK +++K + Q Q R+E E E + ++ E
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEE 655
Query: 505 RVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQ 560
+++ EE+ + +E ++ +E E Q + R +E+K EQ + L+
Sbjct: 656 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR----QEEKMWEQEVRLR 707
Score = 57.4 bits (137), Expect = 5e-08
Identities = 98/482 (20%), Positives = 192/482 (39%), Gaps = 54/482 (11%)
Query: 43 QKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLAT- 101
++L E L K + +E+SE L V E KL A LL P + + A
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELK-------RKLERAKLLLPQQQLQAEADH 330
Query: 102 VKKQLNRVKSKKVVELPLNK--EKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFP 159
+ K+L V +K ++ N+ ++ Q E + + ++ +W+ I + ++ +
Sbjct: 331 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI-QEWEEKIQEQEEKIREQEE 389
Query: 160 LGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEA 219
+EQ + + K QE + K + ++ E+ + LEE
Sbjct: 390 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KIRELEE- 445
Query: 220 KMHRAELQRARALQSYYEAKARKEKKIKS--KKYHKVVKKGKAKKALKEFEQLQKVNPTV 277
KMH E R + E K ++E+KI+ K+ + K + ++ ++E E+ +
Sbjct: 446 KMHEQEKIREQ------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEK 499
Query: 278 ALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDL-EARQAMQEQLAKNKELTQKL 336
+ EKI + + + W + + I + ++ ++ + EQ K ++ +K+
Sbjct: 500 MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKM 559
Query: 337 QVASES--EEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQV 394
E ++EE E EE + W + +E EQ
Sbjct: 560 WRQEEKMHDQEEKIREQEEKV-----------------WRQEEKIREQEEKIR----EQE 598
Query: 395 PELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEV 454
++ E E EE+ +EE + + E+ Q + ++ + E QE K +E
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQ--EQEEKMRRQEEKIREQEKKIREQEEK 656
Query: 455 LSELRALSQKLKEKHQSRKQKASSEGTVPQVQ-----REEPAPEEAEPLLLQRSERVQTL 509
+ E + Q+ +EK +++K + Q Q R+E E E L Q+ E++Q
Sbjct: 657 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 716
Query: 510 EE 511
+E
Sbjct: 717 QE 718
Score = 54.3 bits (129), Expect = 4e-07
Identities = 82/445 (18%), Positives = 185/445 (41%), Gaps = 35/445 (7%)
Query: 177 WKARTPLEQEIFNLLHKNKQP--VTDPLLTPMEKASLQ----AMSLEEAKMHRAELQRAR 230
WK LEQ + + + K+ + L + SL+ ++ EE K A+LQ
Sbjct: 232 WKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL 291
Query: 231 ALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARM 290
L +++ + K +K + ++ E + L K +V+ + ++E +
Sbjct: 292 QLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL 351
Query: 291 MERMSLKHQNSGKWAKSKAIMAKYDL--EARQAMQEQLAKNKELTQKLQVASES--EEEE 346
R++ + Q W + + I + E + ++EQ K +E +K++ E E+EE
Sbjct: 352 WNRLN-QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 410
Query: 347 GGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAA-------TQEDPEQVPELAA 399
EE++ E +M W + +E QE+ Q E
Sbjct: 411 KMRRQEEMMWE---KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 467
Query: 400 HEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELR 459
+ E E + +EE +RE EE+ ++ Q+ + ++ ++ ++ E+
Sbjct: 468 EQEKRQEQEAKMWRQEE-KIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMW 526
Query: 460 ALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEE----LEEL 515
+K++E+ + +QK +++++E E + + E+++ EE EE
Sbjct: 527 RQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEK 586
Query: 516 GKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEK--KEKEQLINLQNFLTTQSPSVRSL 573
+E + +E + E ++ + + +EK +++E++ + + Q +R
Sbjct: 587 IREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQ 646
Query: 574 AVPTIIEELEDEEE--RDQRQMIKE 596
+++ ++EE R+Q +M++E
Sbjct: 647 E-----KKIREQEEKIREQEEMMQE 666
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/360 (20%), Positives = 146/360 (40%), Gaps = 29/360 (8%)
Query: 217 EEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPT 276
+E KM R E R + Q + + + ++++ K + ++K ++ K ++Q +K+
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 277 VALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYD---LEARQAMQEQLAKNKELT 333
+ E EK +M E + + K + + M + + E + MQEQ K E
Sbjct: 589 ERMREREK----KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 334 QKLQVASESE-EEEGGTEVEELLVPH--VANEVQMNVDGPNPWMFRSCTSDTKEAATQED 390
+K+ E E++ E +E L H + + +M W T+E QE
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE---QEK 701
Query: 391 PEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSS 450
E E S E E++ + EEE ++RE EE+ ++ Q+ E +E
Sbjct: 702 KTWDQEKMREEESMREREKK-MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ 760
Query: 451 SQEVLSELRALSQKLK---------------EKHQSRKQKASSEGTVPQVQREEPAPEEA 495
+++ + R QK K ++ + R Q+ G +++ +E
Sbjct: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
Query: 496 EPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQ 555
E + + E++ EE +E + +E ++GQ+ + +E+K +EQ
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
Score = 57.0 bits (136), Expect = 6e-08
Identities = 77/429 (17%), Positives = 175/429 (40%), Gaps = 46/429 (10%)
Query: 217 EEAKMHRAELQRARALQSYYEAKARKEKKI---KSKKYHKVVKKGKAKKALKEFEQLQKV 273
+E + EL+ + L+ E +E+K+ + K + K + ++ L E E+ +
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 274 NPTVALEEMEKI--ENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKE 331
++ E++ ++ R+ E+ + W + + + + MQEQ K ++
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK------MREEKKMQEQEKKTRD 441
Query: 332 LTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDP 391
+K+Q E E EE + E +M N W + KE Q P
Sbjct: 442 QEEKMQEEERIREREKKMREEEETMRE--QEEKMQKQEENMW-----EQEEKEWQQQRLP 494
Query: 392 EQVPELAAHEVSASEAEERPVAEEEIL-----------------LREFEERQSLRKRSEL 434
EQ +L E + E+ EE+I +RE E++ ++
Sbjct: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
Query: 435 NQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEE 494
+Q+ + +E + +QE + +K++E+ + R+++ ++ +E +E
Sbjct: 555 DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 614
Query: 495 AEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKE 554
E + ++ E++ EE + +E ++ +E + Q+ + R KEK +
Sbjct: 615 QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEE----KMWEQEEKMWEQQRLPEQKEKLWEH 670
Query: 555 QLINLQNFLTTQSPSVRSLAVPTIIEELEDE-EERDQRQMIKEAFAGDDVIRDFLKEKRE 613
+ + Q + Q + E++E + +E++++ +E ++ +R+ K+ RE
Sbjct: 671 EKMQEQEKMQEQEEKIWEQ------EKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE 724
Query: 614 AVEASKPKD 622
E + ++
Sbjct: 725 EEEMMREQE 733
Score = 48.5 bits (114), Expect = 2e-05
Identities = 86/452 (19%), Positives = 185/452 (40%), Gaps = 47/452 (10%)
Query: 192 HKNKQPVTDPLLTPMEKASLQ----AMSLEEAKMHRAELQRARALQSYYEAKARKEKKIK 247
HK + L + SL+ ++ EE K AELQ L + E ++
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAE----SEKSEIQLN 247
Query: 248 SKKYHKVVKKGKAKKALKEFEQLQKV--NPTVALEEMEKI---ENARMMERMSLKHQNSG 302
K+ + +++ K + LQ+ L E EK + +M + + G
Sbjct: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307
Query: 303 KWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANE 362
K + + M + + R+ +E + KEL ++ ++ E+EE E EE + E
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKEL---REQEEQMQEQEEKM---WEQE 361
Query: 363 VQMNVDGPNPWMFRSCTSDTKEAATQEDP--EQVPELAAHEVSASEAEERPVAEEEILLR 420
+M W QE+ EQ ++ E + EER + E++ LR
Sbjct: 362 EKMREQEEKMW-------------RQEERLWEQEKQMREQEQKMRDQEER-MWEQDERLR 407
Query: 421 EFEER----QSLRKRSELNQDAEPASSQETKDSSSQEVLSE---LRALSQKLKEKHQSRK 473
E EER + + ++ E ++ + QE K +E + E +R +K++E+ ++ +
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467
Query: 474 QKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLE- 532
++ + E+ E + L ++ E++ E+++E +E ++ +E R E
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE-QEEKIWEQEEKIRDQEEM 526
Query: 533 -GQQSE--RTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERD 589
GQ+ + R R + +++E++ + + + Q + + + EE+
Sbjct: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR 586
Query: 590 QRQMIKEAFAGDDVIRDFLKEKREAVEASKPK 621
+ + ++E + ++E+ E ++ + K
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEK 618
Score = 43.1 bits (100), Expect = 0.001
Identities = 76/347 (21%), Positives = 141/347 (40%), Gaps = 66/347 (19%)
Query: 286 ENARMMERMSLKHQNSGKWAKS---KAIMAKYDLEARQAMQEQLAK-NKELTQKLQVASE 341
E R + +S +H+ + ++ + + +L E+L K N EL +KL +A E
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA-E 238
Query: 342 SEEEEGGTEVEELL-----VPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPE 396
SE+ E V+EL + +VQ N W +E EQ +
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWR-----------QEEELREQEKK 287
Query: 397 LAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLS 456
+ E EER + E+E +RE EE+ +++ Q+
Sbjct: 288 IRKQEEKMWRQEER-LREQEGKMREQEEKMWRQEKRLREQE------------------K 328
Query: 457 ELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELG 516
ELR ++L+E+ + R+Q+ Q+Q +E E E + ++ E++ EE
Sbjct: 329 ELREQEKELREQKELREQE-------EQMQEQEEKMWEQEEKMREQEEKMWRQEE----- 376
Query: 517 KEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEK-KEKEQLINLQNFLTTQSPSVRSLAV 575
+ E + + E +Q R R E+ +EKE+ + Q + Q +R
Sbjct: 377 -----RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR---- 427
Query: 576 PTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKD 622
EE + +E+ + + +E ++ IR+ K+ RE E + ++
Sbjct: 428 ----EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE 470
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 58.5 bits (140), Expect = 2e-08
Identities = 98/492 (19%), Positives = 200/492 (40%), Gaps = 62/492 (12%)
Query: 212 QAMSLEEAKMHRAE---LQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFE 268
+ M +E KM R E ++ + ++ + +E+++ + K+ + ++ K +E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 269 QLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAK 328
Q +K+ + E EK +M E + K K + M ++ E ++ Q++L +
Sbjct: 384 QEEKMQEEERIREREK----KMREEEETMREQEEKMQKQEENM--WEQEEKEWQQQRLPE 437
Query: 329 NKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQ 388
KE + + E EE+ E EE + Q + G M+R ++ Q
Sbjct: 438 QKEKLWEQEKMQEQEEKIW--EQEEKI------RDQEEMWGQEKKMWRQ-----EKMREQ 484
Query: 389 EDP--EQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR----SELNQDAEPAS 442
ED EQ ++ E + EER + E++ LRE EER +K+ E ++ +
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEER-MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543
Query: 443 SQETKDSSSQEVLSE---LRALSQKLKEKHQSRKQKASS--EGTVPQVQREEPAPEEAEP 497
QE K +E + E +R +K++E+ + +++ E ++EE E+ E
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK 603
Query: 498 LLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLI 557
+ Q + + E++ E +ED Q +E E + E+ K ++++E++
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR 663
Query: 558 NLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEA 617
+ + Q E++ ++EE+ Q Q K ++E+ E +
Sbjct: 664 EQEEKMQGQE------------EKMREQEEKMQGQEEK------------MREQEEKMRG 699
Query: 618 SKPKDVDLTLPGWGE----WGGVGLKPSAKKRRQFLIKAPEGPPRKDKNLPNVIISEKRN 673
+ K WG+ WG ++ ++ R K E P ++ + +
Sbjct: 700 QEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKV 759
Query: 674 IHAAAHQVQVLP 685
+ +H V P
Sbjct: 760 LCNMSHTGSVEP 771
Score = 49.7 bits (117), Expect = 1e-05
Identities = 85/384 (22%), Positives = 161/384 (41%), Gaps = 36/384 (9%)
Query: 261 KKALKEFEQLQKVNPTVALE--------EMEKIENARMMERMSLKHQNSG------KWAK 306
KKA + E+L K ++LE E K +NA + E++ L K K
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214
Query: 307 SKAIMAKYDLEARQA--MQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQ 364
K AK+ L Q +QE++ + +E ++ + +EE+ + E L Q
Sbjct: 215 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 274
Query: 365 MNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEE 424
R + +E +++ + +L E E EE+ + E+E +RE EE
Sbjct: 275 EEKMRRQEKRLREQEKELREQ--EKELREQKKLREQEEQMQEQEEK-MWEQEEKMREQEE 331
Query: 425 RQSLRKRSELNQDAEPASSQETKDSSSQEVLSE----LRALSQKLKEKHQSRKQKASSEG 480
+ R+ L + + QE K +E + E LR ++++E+ + +Q+ +
Sbjct: 332 KM-WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQ- 389
Query: 481 TVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTP 540
+++ E E E + ++ E++Q EE +E +Q + LP +Q E+
Sbjct: 390 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP------EQKEKLW 443
Query: 541 NNRPDAPKEKK--EKEQLINLQNFLTTQSPSV-RSLAVPTIIEELEDEEE--RDQRQMIK 595
+E+K E+E+ I Q + Q + R + +++ ++EE RDQ Q +
Sbjct: 444 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 596 EAFAGDDVIRDFLKEKREAVEASK 619
+ + L+EK E + K
Sbjct: 504 DQEERMWEQDERLREKEERMREQK 527
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 58.5 bits (140), Expect = 2e-08
Identities = 122/636 (19%), Positives = 248/636 (38%), Gaps = 104/636 (16%)
Query: 38 GERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSS 97
G+ Q++ E +L+ N K + ++ + E E+ L D T +
Sbjct: 147 GDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRD-----DTEA 201
Query: 98 SLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLV 157
++ ++K ++ +V++ L+K K++ + EVAF L++ E++
Sbjct: 202 AIRALRKD---IEEASLVKVELDK-KVQSLQDEVAF--------------LRSNHEEEVA 243
Query: 158 FPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLE 217
L + Q + +E + L+ +I L + + + M +A +
Sbjct: 244 DLLAQIQASHITVER-------KDYLKTDISTALKEIRSQLESHSDQNMHQAE-EWFKCR 295
Query: 218 EAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKG---KAKKALKEFEQLQKVN 274
AK+ A Q A++S E A ++++SK +G ++ L + E+ +
Sbjct: 296 YAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHD 355
Query: 275 PTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDL-EARQAMQEQLAKNKEL- 332
+ + ++++EN KW ++ + DL + A+ ++A ++L
Sbjct: 356 LSSYQDTIQQLEN----------ELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLL 405
Query: 333 -------------------TQKLQVASESEEEEGGTEVEELLVPHVANEV---QMNVDGP 370
T + + S+ ++ E +L V H E + V+
Sbjct: 406 EGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDE 465
Query: 371 NPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLR----EFEERQ 426
M + T+ T+E A E+ E A + EAEE VA ++ ++ E +E +
Sbjct: 466 KSEMEEALTAITEELAVSMKEEK-KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEE 524
Query: 427 SLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEGTVPQVQ 486
K E Q+ E + K ++E SE S+K + + + + +A +EG + +
Sbjct: 525 G-EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583
Query: 487 REEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELP-----------RPVLEGQQ 535
E+ E +SE V T EEL K + + + P PV +
Sbjct: 584 EEKKVEE--------KSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV 635
Query: 536 SERTPNNRPDAPKEKKEKEQLINLQNFLTTQSP--------SVRSLAVPTIIEELEDEEE 587
E+ + P +P E+K K + +SP +S + +EE + + E
Sbjct: 636 EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE 695
Query: 588 RDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDV 623
+ + +E + +++ KE++ + KPKDV
Sbjct: 696 VGKGEQKEEE---EKEVKEAPKEEKVEKKEEKPKDV 728
Score = 40.0 bits (92), Expect = 0.008
Identities = 111/574 (19%), Positives = 217/574 (37%), Gaps = 79/574 (13%)
Query: 40 RKHQKLLEAIISLDGKNR--RKLAERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSS 97
R++Q LL ++LD + RKL E E + S F+ S G L P+ SS
Sbjct: 382 REYQDLLNVKMALDIEIAAYRKLLEGEET--RFSTFAGSITGP-----LYTHRPPITISS 434
Query: 98 SLATVKKQLNRVKSK-KVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQL 156
+ K + ++K + K VE + + K+E E+ + T+ E+L
Sbjct: 435 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAIT--------------EEL 480
Query: 157 VFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTPME--KASLQAM 214
+ +E+ A K P +E K+ T P + E K +
Sbjct: 481 AVSMKEEKKEAAEE-------KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ 533
Query: 215 SLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVN 274
EE + A+ +A S E + KE+ + + + +G+ +A +E + +K
Sbjct: 534 EEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE 593
Query: 275 PTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQ 334
EE+ E+ S K K+ + K +E K K
Sbjct: 594 EVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE---------KGKSPVP 644
Query: 335 KLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQV 394
K V + + + VEE G +P S +E A P+
Sbjct: 645 KSPVEEKGKSPVPKSPVEE--------------KGKSP----VSKSPVEEKAKSPVPKSP 686
Query: 395 PELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQET--KDSSSQ 452
E A + + E++ E+E+ +E + + + K+ E +D E+ K+ +
Sbjct: 687 VEEAKSKAEVGKGEQKEEEEKEV--KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 744
Query: 453 EVLSELRALSQKLKE---------KHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRS 503
EV++ +++ L++ + + K+KA EG + ++ A + +
Sbjct: 745 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNG 804
Query: 504 ERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFL 563
E V+ EE+E+ KE +E V G + +P + + +EK + +
Sbjct: 805 E-VEGKEEVEQETKEKGSGREEEKGVVTNG--LDLSPADEKKGGDKSEEKVVVTKTVEKI 861
Query: 564 TTQSPSVRSLAVP---TIIEELEDEEERDQRQMI 594
T++ + + T+ +++E+ EE + +++
Sbjct: 862 TSEGGDGATKYITKSVTVTQKVEEHEETFEEKLV 895
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 58.2 bits (139), Expect = 3e-08
Identities = 127/679 (18%), Positives = 258/679 (37%), Gaps = 79/679 (11%)
Query: 28 SENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEASLKVSEFSVSSEGSGEKLG-- 85
+E E++ +S ER + E + KN + AE ++ K E + +G
Sbjct: 147 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 206
Query: 86 -LADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWD 144
+ ++E T S TV L + E P +E+ EQ E++ + + K
Sbjct: 207 QVEVMVEEKTTESQEETVVMSLKNGQISS--EEPKQEEEREQGSDEISHHEKMEEEDK-- 262
Query: 145 PIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKARTPLEQEIFNLLHKNKQPVTDPLLT 204
+ +AE+ + + A + ++ +AR E++ + ++ +
Sbjct: 263 ----ERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
Query: 205 PMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKAL 264
EK + + + + RA +R R + A A + ++IK ++ ++ +A+
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA-AEERQRIKEEEKRAAEERQRARAEE 377
Query: 265 KEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQE 324
+E ++++ LEE + ++ ++ + GKW K A+ D +++
Sbjct: 378 EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK--AQEDKLQTAVLKK 435
Query: 325 QLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKE 384
Q +E K+Q E +E+ T +E + + + + +M D K+
Sbjct: 436 Q---GEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM------DRKK 486
Query: 385 AATQEDPEQVPELAAHEVSASEAE-ERPVAEEEILLREFEERQSLRKRSELNQDAEPASS 443
T E Q E H++ +E RP + +E E + L +
Sbjct: 487 GFT-EVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE 545
Query: 444 QETKDSSSQEVLSELRALS-QKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQR 502
E+++ + + AL ++LK+K + R++ V + + + EEA+ L +
Sbjct: 546 TESEEFEKLKQKQQEAALELEELKKKREERRK-------VLEEEEQRRKQEEADRKLREE 598
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNF 562
E+ + EE+E E + +++P +G ++ P + E+ N
Sbjct: 599 EEKRRLKEEIERRRAEAAEKRQKMPE---DGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 655
Query: 563 LTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKD 622
+S V+S I+ +++ E+ + E ++ + +KP
Sbjct: 656 SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAI----------------EGTKSAKPTKPAA 699
Query: 623 VDLTLPGWG--------EWGGV---------------GLKPSAKKR-RQFLIKAPEG--- 655
DL +P G E G V GLK R ++L K P+G
Sbjct: 700 SDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKS 759
Query: 656 PPRKDKNLPNVIISEKRNI 674
P K +L +S KRN+
Sbjct: 760 PAPKPSDLRPGDVSSKRNL 778
Score = 48.9 bits (115), Expect = 2e-05
Identities = 76/403 (18%), Positives = 161/403 (39%), Gaps = 73/403 (18%)
Query: 259 KAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEA 318
+ K+ + E+ ++ +PT+ + +R M+ + +++ + K KS++ +Y++E
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSL--PSRRMQNDTAENETTEKEEKSESRQERYEIEE 164
Query: 319 RQAMQEQLAKNK----ELTQKLQVASESEEEEGG------------------TEVEELLV 356
+ + + KN E +K E EEEE TE +E V
Sbjct: 165 TETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETV 224
Query: 357 PHVANEVQMNVDGPNPWMFRSCTSDT---KEAATQEDPEQVP------------------ 395
Q++ + P R SD E +ED E+
Sbjct: 225 VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ 284
Query: 396 -ELAAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEV 454
+ A E + EAEE+ A+E ER+ +R + ++ + A+ + + ++
Sbjct: 285 DKKIADERARIEAEEKAAAQE-------RERREAEERERMREEEKRAAEERQRIKEEEKR 337
Query: 455 LSELRALSQKLKEKHQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEE 514
+E R ++ +++ +Q+ E +R+ EE E ++ +R + LEE +
Sbjct: 338 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
Query: 515 LGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLA 574
+E + +++ + + EG+ EKK +E LQ + + +
Sbjct: 398 AMQETKIKGEKVEQKI-EGKW-----------VNEKKAQED--KLQTAVLKKQGEEKGTK 443
Query: 575 VPTIIEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEA 617
V E+L++++ +++ IK+ D KE +E V++
Sbjct: 444 VQAKREKLQEDKPTFKKEEIKDEKIKKD------KEPKEEVKS 480
Score = 35.8 bits (81), Expect = 0.15
Identities = 47/207 (22%), Positives = 81/207 (39%), Gaps = 27/207 (13%)
Query: 421 EFEERQSLR--KRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASS 478
+FE R+ LR KR E+ +AE + Q D +E E R ++ +++ +KQ+ S
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQR-NDDDEEEAARERR---RRARQERLRQKQEEES 58
Query: 479 EGTVP---QVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQ 535
G V +V + P+E E T + G ++ + L R +
Sbjct: 59 LGQVTDQVEVNAQNSVPDE---------EAKTTTTNTQVEGDDEAAFLERLAR------R 103
Query: 536 SERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIK 595
ER +A + +KE + I + A E+ E E R +R I+
Sbjct: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
Query: 596 EAFAGDDVIRDFLKEKREAVEASKPKD 622
E + V + + K E +K +D
Sbjct: 164 ET---ETVTKSYQKNDWRDAEENKKED 187
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2135 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2180
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2181 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2477 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2512
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 625 L 625
L
Sbjct: 2573 L 2573
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1609 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1661
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1721 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1770
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1831 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1887
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1888 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1947 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2060
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1644
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1705 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1882
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1943 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 2002 RQRKAALEE 2010
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1290 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1343
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1344 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1462 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 621 K 621
K
Sbjct: 1759 K 1759
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2205
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2257
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2318 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2376 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2424
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2425 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2470
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2527
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2139 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2184
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2185 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2481 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2516
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2576
Query: 625 L 625
L
Sbjct: 2577 L 2577
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1613 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1665
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1666 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1724
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1725 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1774
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1835 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1891
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1892 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1951 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2007
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 2008 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2064
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1648
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1709 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1767
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1768 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1827
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1828 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1886
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1947 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 2006 RQRKAALEE 2014
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1294 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1347
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1348 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1406 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1466 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 621 K 621
K
Sbjct: 1763 K 1763
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2209
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2210 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2261
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2322 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2380 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2428
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2429 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2474
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2531
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2135 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2180
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2181 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2477 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2512
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2572
Query: 625 L 625
L
Sbjct: 2573 L 2573
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1609 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1661
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1662 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1721 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1770
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1831 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1887
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1888 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1947 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 2004 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2060
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1644
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1705 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1882
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1943 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 2002 RQRKAALEE 2010
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1290 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1343
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1344 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1402 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1462 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 621 K 621
K
Sbjct: 1759 K 1759
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2205
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2206 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2257
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2318 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2376 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2424
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2425 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2470
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2527
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2103 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2148
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2149 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2445 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2480
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2540
Query: 625 L 625
L
Sbjct: 2541 L 2541
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1577 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1629
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1630 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1688
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1689 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1738
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1799 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1855
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1856 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1915 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1971
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 1972 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2028
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2088
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1612
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1673 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1731
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1732 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1791
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1792 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1850
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1911 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 1970 RQRKAALEE 1978
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1258 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1311
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1312 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1370 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1430 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1606
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 621 K 621
K
Sbjct: 1727 K 1727
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2173
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2174 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2225
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2286 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2344 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2392
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2393 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2438
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2495
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2272 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2317
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2318 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2493
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2614 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2649
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2709
Query: 625 L 625
L
Sbjct: 2710 L 2710
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1746 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1798
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1799 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1857
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1858 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1907
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1968 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 2024
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 2025 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 2084 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2140
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 2141 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2197
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1781
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1842 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1900
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1901 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1960
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1961 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 2019
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 2080 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 2139 RQRKAALEE 2147
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1427 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1480
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1481 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1539 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1599 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 621 K 621
K
Sbjct: 1896 K 1896
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2342
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2394
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2455 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2513 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2561
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2562 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2607
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2664
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2113 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2158
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2159 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2334
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2455 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2490
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2491 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2550
Query: 625 L 625
L
Sbjct: 2551 L 2551
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1587 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1639
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1640 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1698
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1699 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1748
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1809 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1865
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1866 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1925 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1981
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 1982 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2038
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2098
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1622
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1683 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1741
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1742 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1801
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1802 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1860
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1921 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 1980 RQRKAALEE 1988
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1268 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1321
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1322 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1380 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1440 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1616
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 621 K 621
K
Sbjct: 1737 K 1737
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2183
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2184 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2235
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2296 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2354 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2402
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2403 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2448
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2505
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2121 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2166
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2167 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2342
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2463 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2498
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2499 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2558
Query: 625 L 625
L
Sbjct: 2559 L 2559
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1595 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1647
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1648 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1706
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1707 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1756
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1757 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1817 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1873
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1874 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1933 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1989
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 1990 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2046
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2106
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1630
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1691 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1749
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1750 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1809
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1810 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1868
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1929 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 1988 RQRKAALEE 1996
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1276 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1329
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1330 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1388 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1448 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1624
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 621 K 621
K
Sbjct: 1745 K 1745
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2191
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2192 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2243
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2304 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2362 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2410
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2411 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2456
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2513
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 57.0 bits (136), Expect = 6e-08
Identities = 118/661 (17%), Positives = 248/661 (37%), Gaps = 84/661 (12%)
Query: 7 AENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKLAERSEA 66
AE+ S ++ ++ + L+ E+ + E + QK L A + + L E
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041
Query: 67 SLKVSEF----SVSSEGSGEKLGLAD-----LLEPVKTSSSLATVKKQ--LNRVKSKKVV 115
KV E + + S +L LA L+ + + + A +K+ L + ++
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 116 ELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALS 175
L + + E R ++ ++V ++ + + Q E E+ A A + +
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161
Query: 176 GWKARTPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSY 235
K R EQE E+A+L+ +A+M + + + L+
Sbjct: 2162 AEKLRKEAEQEAARRAQA-------------EQAALRQKQAADAEMEKHKKFAEQTLRQ- 2207
Query: 236 YEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMS 295
KA+ E+++ + + ++ + K L E Q K T A + ++E R+
Sbjct: 2208 ---KAQVEQELTTLRL-QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 296 LKHQNSGKW---AKSKAIMAKYDLEARQAMQEQLAKNKELTQ---KLQVASESEE----- 344
++ + K A+++A++ + ++ +QE+ K K++ + +L VA++
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323
Query: 345 -EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAAT------QEDPEQVPEL 397
EE + L + ++Q + KE A QED EQ+ +
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2383
Query: 398 AAHEVSASEAEERPVAEEEILLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSE 457
A E + + ++ + ER LR A + ++E+ +
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2443
Query: 458 LRALSQKLKEK-----------HQSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERV 506
L +EK QS + +++RE+ ++ LL +SE +
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 507 QTLEELEELGKEDCFQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQ 566
QT+++ + L + Q L EK+ L+ + F+ +
Sbjct: 2504 QTVQQEQLLQETQALQQSFL------------------------SEKDSLLQRERFIEQE 2539
Query: 567 SPSVRSLAVPTI--IEELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKPKDVD 624
+ L + ++L +E++R Q+QM +E + + + + EA E + K +
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE 2599
Query: 625 L 625
L
Sbjct: 2600 L 2600
Score = 56.2 bits (134), Expect = 1e-07
Identities = 135/643 (20%), Positives = 262/643 (40%), Gaps = 86/643 (13%)
Query: 37 DGERKHQKLLEAIISLDGKNRRKLAERS--EASLKVSE---FSVSSEGSGEKLGLADLLE 91
+ ER+ Q+ EA + R+ AER LK +E + +E ++ LA E
Sbjct: 1636 EAERRAQQQAEA------ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA-E 1688
Query: 92 PVKTSSSLATVKKQLNRVKSKKVVELPLNKEKIEQIHREVAFSKTSQVLSKWDPIILKNQ 151
K ++ + + + V + L ++++E+ R++A Q L+ +I
Sbjct: 1689 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQELIRLRA 1747
Query: 152 QAEQLVFPLGKEQPAIAPIE------HALSGWKARTPLEQEIFNLLHKNKQPVTDPLLTP 205
+ EQ G++Q + E A + + R LE E+ + + + LL
Sbjct: 1748 ETEQ-----GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEVLLAS 1797
Query: 206 MEKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKK--- 262
+A ++ S E R E + R + EA + ++K+ ++ ++ A++
Sbjct: 1798 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 263 ----------ALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMA 312
A+ E +L K +AL+E E EN R+ R++ + + +A
Sbjct: 1858 AERVLAEKLAAIGEATRL-KTEAEIALKEKEA-ENERL-RRLAEDEAFQRRRLEEQAAQH 1914
Query: 313 KYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPH-----VANEVQMNV 367
K D+E R A Q + A + EL ++ + ++ + E E L + A + ++ +
Sbjct: 1915 KADIEERLA-QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 368 DGPNPWMFRSCTSDT---KEAATQEDPEQVPELAAHEVSASEAEERP----VAEEEI--- 417
+ RS DT KE A E Q A E EAEER AEEE
Sbjct: 1974 ELGR---IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2030
Query: 418 ----------LLREFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKE 467
L + EE + LR+R+E + +QE ++ + + +E +A + +++
Sbjct: 2031 RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE---AAQKRLQAEEKAHAFAVQQ 2087
Query: 468 KHQSRKQKASSEGTVPQVQREEP-----APEEAEPLLLQ-RSERVQTLEELEELGK-EDC 520
K Q +Q E +V R E A EEAE +Q E Q+ ++EE + +
Sbjct: 2088 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2147
Query: 521 FQNKELPRPVLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIE 580
+ + R + + +A + + ++ + + + + A T+ +
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207
Query: 581 ELEDEEE-RDQRQMIKEAFAGDDVIRDFLKE-KREAVEASKPK 621
+ + E+E R ++E +++ + L+ K EA EA++ +
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
Score = 54.3 bits (129), Expect = 4e-07
Identities = 90/429 (20%), Positives = 182/429 (42%), Gaps = 44/429 (10%)
Query: 207 EKASLQAMSLEEAKMHRAELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKE 266
EK + SL+E + A+L+ ++ +A+A + ++ ++ + + KA +AL+
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW--QLKANEALRL 1671
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAM---- 322
Q ++V +L + E + ER + + + + A + +A+ +LE ++ +
Sbjct: 1672 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 323 -QEQLAKNKELTQKLQVASESEEEEGGTEVEEL--LVPHVANEVQMNVD----------G 369
Q++LA +EL +L+ +E E++ EEL L A Q +
Sbjct: 1732 AQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1790
Query: 370 PNPWMFRSCTSDTKEAATQEDPEQVPELAA---HEVSASEAEERPVAEEEILLREFEERQ 426
+ ++ + +T E +Q E A E++ A R +AEE R+ E
Sbjct: 1791 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1850
Query: 427 SLRKRSE-----------------LNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKH 469
+ R+R+E L +AE A ++ ++ L+E A Q+ + +
Sbjct: 1851 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF-QRRRLEE 1909
Query: 470 QSRKQKASSEGTVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRP 529
Q+ + KA E + Q+++ + E + L++ + R + E E L + F+ +
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 530 VLEGQQSERTPNNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEE-- 587
LE + R +N D + K++ E Q L + R A + + L EEE
Sbjct: 1970 ELE-LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 588 RDQRQMIKE 596
R ++ ++E
Sbjct: 2029 RQRKAALEE 2037
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/481 (20%), Positives = 183/481 (38%), Gaps = 78/481 (16%)
Query: 208 KASLQAMSLEEAKMHRAELQRARALQSYYEAKAR-KEKKIKSKKYHKVVKKGKAKKALKE 266
KA L+ ++ AK + + +Q Y + + E + +Y K + + L+
Sbjct: 1317 KAQLEPVA-SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE-----TLRR 1370
Query: 267 FEQLQKVNPTVALEEMEKIENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQL 326
E+ +++ EE E++ A + + + Q + A++KA + E +Q MQE++
Sbjct: 1371 MEEEERLAEQQRAEERERL--AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 327 AKNKELT-----QKLQVASESEEEEGGTEVE---ELLVPHVANEVQMNVDGPNPWMFRSC 378
+ +E QK + E ++ +E E + A ++ ++ +
Sbjct: 1429 VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 379 TSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLREFEERQSLRKR------- 431
+ ++ E Q A E +EA++R EE LR + +S RKR
Sbjct: 1489 EATERQRGGAEGELQALRARAEE---AEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545
Query: 432 --------------------SELNQDAEPASSQ----------------ETKDSSSQEVL 455
EL AE A + ET S++ L
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1605
Query: 456 SELRA--------LSQKLKEKHQSRKQ-KASSEGTVPQVQREEPAPEEAEPLL----LQR 502
RA L + L+E+H + Q + +E Q E A EEAE L L+
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1665
Query: 503 SERVQTLEELEELGKEDCFQNKELPRPVLEGQ-QSERTPNNRPDAPKEKKEKEQLINLQN 561
+E ++ + EE+ ++ E + E + ++ R A ++++ EQ + Q
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 562 FLTTQSPSVRSLAVPTIIE-ELEDEEERDQRQMIKEAFAGDDVIRDFLKEKREAVEASKP 620
L + R A +I E E+ QRQ+++E A +KR+ +EA
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 621 K 621
K
Sbjct: 1786 K 1786
Score = 44.3 bits (103), Expect = 4e-04
Identities = 88/471 (18%), Positives = 199/471 (42%), Gaps = 62/471 (13%)
Query: 61 AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN 120
A+ +A+L+ + + + +K L + + L T++ QL +K L
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK----NLL 2232
Query: 121 KEKIEQIHREV--AFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWK 178
E+++++ E A + SQV + + ++ ++ +L + E A+ +
Sbjct: 2233 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--------LR 2284
Query: 179 ARTPLEQEIFNLLHKNKQPVTDPL---LTPMEKASLQAMSLEEAKMHRA----------- 224
+ ++ + K KQ + + E A L+ ++ E+ RA
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344
Query: 225 ELQRARALQSYYEAKARKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEK 284
+Q A L++ EA+ +++K +++ + +++ K + A + E+ Q T+ E +
Sbjct: 2345 AVQEATRLKA--EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402
Query: 285 IENARMMERMSLKHQNSGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEE 344
+E + ER+ L+ A M++ A + Q + +E+ +KL +E
Sbjct: 2403 LEMSAEAERLKLR----------VAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELAT 2451
Query: 345 EEGGTEVEELLVPHVANEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSA 404
+E T V+ L E+Q + R ++ + + E++ + A ++
Sbjct: 2452 QEKVTLVQTL-------EIQRQQSDHDAERLREAIAEL-----EREKEKLQQEA--KLLQ 2497
Query: 405 SEAEERPVAEEEILLREFEERQS--LRKRSELNQDAEPASSQETKDSSSQEVLSELRALS 462
++EE ++E LL+E + Q L ++ L Q ++ K +++ + A +
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK---LEQLFQDEVAKA 2554
Query: 463 QKLKEKHQSRKQKASSEGT--VPQVQREEPAPEEAEPLLLQRSERVQTLEE 511
Q+L+E+ Q ++Q+ E V ++ EAE + ++ E +Q LE+
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,109,184
Number of Sequences: 37866
Number of extensions: 1432527
Number of successful extensions: 10213
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 958
Number of HSP's that attempted gapping in prelim test: 6986
Number of HSP's gapped (non-prelim): 2863
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.