Search of human proteins with 13376848

Search of human proteins with 13376848

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo
sapiens]
         (482 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens]    971   0.0  
gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]              749   0.0  
gi|59814146 BTB (POZ) domain containing 1 isoform 2 [Homo sapiens]    703   0.0  
gi|225543407 BTB domain protein BDPL [Homo sapiens]                   382   e-106
gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo s...   366   e-101
gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo ...   366   e-101
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    102   6e-22
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]                    102   6e-22
gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]   101   1e-21
gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]   101   1e-21
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom...    84   3e-16
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo...    81   2e-15
gi|211904190 hypothetical protein LOC149478 [Homo sapiens]             79   7e-15
gi|151108435 BTB (POZ) domain containing 9 isoform b [Homo sapiens]    77   3e-14
gi|166235129 kelch-like 3 [Homo sapiens]                               75   1e-13
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]     74   2e-13
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]             74   3e-13
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]             73   5e-13
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                      72   9e-13
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                      72   9e-13
gi|40807500 kelch-like 20 [Homo sapiens]                               72   9e-13
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]         72   1e-12
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]         72   1e-12
gi|55925604 kelch-like 18 [Homo sapiens]                               70   4e-12
gi|38194229 kelch-like 17 [Homo sapiens]                               69   7e-12
gi|126116565 MYC binding protein 2 [Homo sapiens]                      69   9e-12
gi|5174473 intracisternal A particle-promoted polypeptide isofor...    69   1e-11
gi|223890235 intracisternal A particle-promoted polypeptide isof...    69   1e-11
gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo...    68   2e-11
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]               68   2e-11

>gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens]
          Length = 482

 Score =  971 bits (2509), Expect = 0.0
 Identities = 482/482 (100%), Positives = 482/482 (100%)

Query: 1   MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFA 60
           MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFA
Sbjct: 1   MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFA 60

Query: 61  FLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE 120
           FLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE
Sbjct: 61  FLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE 120

Query: 121 LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA 180
           LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
Sbjct: 121 LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA 180

Query: 181 FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL 240
           FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL
Sbjct: 181 FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL 240

Query: 241 FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREV 300
           FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREV
Sbjct: 241 FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREV 300

Query: 301 VNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRIS 360
           VNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRIS
Sbjct: 301 VNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRIS 360

Query: 361 IVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPN 420
           IVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPN
Sbjct: 361 IVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPN 420

Query: 421 VCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIF 480
           VCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIF
Sbjct: 421 VCYTACATLKGPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIF 480

Query: 481 YT 482
           YT
Sbjct: 481 YT 482


>gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]
          Length = 525

 Score =  749 bits (1935), Expect = 0.0
 Identities = 381/491 (77%), Positives = 417/491 (84%), Gaps = 22/491 (4%)

Query: 7   AAAGEQASGAEAEPGPAGPPPPPSP-------------SSLGP-LLPLQREPLYNWQATK 52
           AAA   A+ A A PGP  PP PP P              + GP    LQRE  YNWQA+K
Sbjct: 42  AAAAAAAAAAAAAPGPT-PPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASK 100

Query: 53  ASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGM 112
            +++ERFAFLFN+E+L DV F++GKG  +      QRIPAHRFVLA GSAVFDAMFNGGM
Sbjct: 101 PTVQERFAFLFNNEVLCDVHFLVGKGLSS------QRIPAHRFVLAVGSAVFDAMFNGGM 154

Query: 113 ATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLT 172
           ATTS EIELPDVEPAAFLALL+FLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 
Sbjct: 155 ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLK 214

Query: 173 KHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDT 232
           K+LRADNAFMLLTQARLFDEPQLASLCL+ IDK+T DAI+AEGFTDID+DTL AVLERDT
Sbjct: 215 KNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDT 274

Query: 233 LSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQS 292
           L IRE RLF AVVRW+EAECQRQQL VT  N++KVLGKAL LIRFPLMTIEEFAAGPAQS
Sbjct: 275 LGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQS 334

Query: 293 GILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIR 352
           GIL DREVV+LFLHFTVNPKPRVE+IDRPRCCLRGKEC INRFQQVESRWGYSGTSDRIR
Sbjct: 335 GILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIR 394

Query: 353 FTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFK 412
           F+VN+RI +VGFGLYGSIHGPTDYQVNIQII  +    LGQNDTGFSCDG+A+TFRVMFK
Sbjct: 395 FSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFK 454

Query: 413 EPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETP-AASKTVFFFFSSPGNNNGTSIE 471
           EP+E+LPNV YTACATLKGPDSHYGTKGL+KV HE+P   +KT F F  + GNNNGTS+E
Sbjct: 455 EPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVE 514

Query: 472 DGQIPEIIFYT 482
           DGQIPE+IFYT
Sbjct: 515 DGQIPEVIFYT 525


>gi|59814146 BTB (POZ) domain containing 1 isoform 2 [Homo sapiens]
          Length = 385

 Score =  703 bits (1815), Expect = 0.0
 Identities = 355/360 (98%), Positives = 357/360 (99%), Gaps = 1/360 (0%)

Query: 1   MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFA 60
           MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFA
Sbjct: 1   MASLGPAAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFA 60

Query: 61  FLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE 120
           FLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE
Sbjct: 61  FLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE 120

Query: 121 LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA 180
           LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA
Sbjct: 121 LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA 180

Query: 181 FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL 240
           FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL
Sbjct: 181 FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL 240

Query: 241 FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREV 300
           FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREV
Sbjct: 241 FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREV 300

Query: 301 VNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIRFTVNRRIS 360
           VNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIR ++N R S
Sbjct: 301 VNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIR-SLNMRKS 359


>gi|225543407 BTB domain protein BDPL [Homo sapiens]
          Length = 485

 Score =  382 bits (981), Expect = e-106
 Identities = 211/479 (44%), Positives = 296/479 (61%), Gaps = 21/479 (4%)

Query: 7   AAAGEQASGAEAEPGPAGPPPPPSPSSLGPLLPLQREPLYNWQATKASLKERFAFLFNSE 66
           AA G +A        PA  PPPP+P+   P L    +    W+  + +L+ER A +FN+E
Sbjct: 23  AAVGRKAGPRSPPSAPAPAPPPPAPAP--PTLGNNHQESPGWRCCRPTLRERNALMFNNE 80

Query: 67  LLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 126
           L++DV FV+G        G  + +PAH++VLA GS+VF AMF G +A   +EI +PDVEP
Sbjct: 81  LMADVHFVVGP------PGATRTVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVEP 134

Query: 127 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQ 186
           AAFL LL+++YSDE+ +  +TV+ TLY AKKY VPAL   CV FL   L A NA +LL+Q
Sbjct: 135 AAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNFLETSLEAKNACVLLSQ 194

Query: 187 ARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVR 246
           +RLF+EP+L   C + ID     A+ +EGF +ID  TL  ++ R+ L+ +E+ +F AV+ 
Sbjct: 195 SRLFEEPELTQRCWEVIDAQAEMALRSEGFCEIDRQTLEIIVTREALNTKEAVVFEAVLN 254

Query: 247 WAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFLH 306
           WAEAEC+RQ LP+T  NK+ VLG+AL L+R P MT+EEFA G AQS IL+  E  ++FL 
Sbjct: 255 WAEAECKRQGLPITPRNKRHVLGRALYLVRIPTMTLEEFANGAAQSDILTLEETHSIFLW 314

Query: 307 FTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ESRWGYSGTSDRIRFTVNRRISIVG 363
           +T   KPR+++    R  L  + C  +RFQ      ++W Y G  D I+F V+RR+ I G
Sbjct: 315 YTATNKPRLDFPLTKRKGLAPQRC--HRFQSSAYRSNQWRYRGRCDSIQFAVDRRVFIAG 372

Query: 364 FGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFKEPIEILPNVCY 423
            GLYGS  G  +Y V I++        L QN T F  DG++NTF V F+ P+++  +  Y
Sbjct: 373 LGLYGSSSGKAEYSVKIEL--KRLGVVLAQNLTKFMSDGSSNTFPVWFEHPVQVEQDTFY 430

Query: 424 TACATLKGPD-SHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIFY 481
           TA A L G + S++G +G+ +V        K  F F  S  + NGT ++ GQIPE+IFY
Sbjct: 431 TASAVLDGSELSYFGQEGMTEV-----QCGKVAFQFQCSSDSTNGTGVQGGQIPELIFY 484


>gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo
           sapiens]
          Length = 522

 Score =  366 bits (939), Expect = e-101
 Identities = 197/444 (44%), Positives = 280/444 (63%), Gaps = 23/444 (5%)

Query: 44  PLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAV 103
           P  NWQ    +++ER A +FN++L++DV FV+G        GG QR+P H++VLA GS+V
Sbjct: 95  PAPNWQGLYPTIRERNAMMFNNDLMADVHFVVGP------PGGTQRLPGHKYVLAVGSSV 148

Query: 104 FDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 163
           F AMF G +A    EI +PDVEPAAFLA+L+++Y DE+ +  +TV+ TLY AKKY VP L
Sbjct: 149 FHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHL 208

Query: 164 EAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDT 223
              CV FL   L A NA +LL+Q+ LF+EP L   C + ID     A+ +EGF DID  T
Sbjct: 209 ARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQT 268

Query: 224 LCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIE 283
           L ++L R+TL+ +E  +F A + WAE ECQRQ L ++  NK+KVLGKAL LIR P M ++
Sbjct: 269 LESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALD 328

Query: 284 EFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ES 340
           +FA G AQSG+L+  E  ++FL +T   KP ++++ + R  L  + C  +RFQ      +
Sbjct: 329 DFANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSN 386

Query: 341 RWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQ--TLGQNDTGF 398
           +W Y G  D I+F V++R+ I GFGLYGS  G  +Y   I++    K+Q   LGQN + +
Sbjct: 387 QWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIEL----KRQGVVLGQNLSKY 442

Query: 399 SCDGTANTFRVMFKEPIEILPNVCYTACATLKGPD-SHYGTKGLKKVVHETPAASKTVFF 457
             DG++NTF V F+ P++I P+  YTA   L G + S++G +G+ +V        K    
Sbjct: 443 FSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEV-----QCGKVTVQ 497

Query: 458 FFSSPGNNNGTSIEDGQIPEIIFY 481
           F  S  + NGT ++ GQIPE+IFY
Sbjct: 498 FQCSSDSTNGTGVQGGQIPELIFY 521


>gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo
           sapiens]
          Length = 461

 Score =  366 bits (939), Expect = e-101
 Identities = 197/444 (44%), Positives = 280/444 (63%), Gaps = 23/444 (5%)

Query: 44  PLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAV 103
           P  NWQ    +++ER A +FN++L++DV FV+G        GG QR+P H++VLA GS+V
Sbjct: 34  PAPNWQGLYPTIRERNAMMFNNDLMADVHFVVGP------PGGTQRLPGHKYVLAVGSSV 87

Query: 104 FDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 163
           F AMF G +A    EI +PDVEPAAFLA+L+++Y DE+ +  +TV+ TLY AKKY VP L
Sbjct: 88  FHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHL 147

Query: 164 EAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDT 223
              CV FL   L A NA +LL+Q+ LF+EP L   C + ID     A+ +EGF DID  T
Sbjct: 148 ARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQT 207

Query: 224 LCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIE 283
           L ++L R+TL+ +E  +F A + WAE ECQRQ L ++  NK+KVLGKAL LIR P M ++
Sbjct: 208 LESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALD 267

Query: 284 EFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ES 340
           +FA G AQSG+L+  E  ++FL +T   KP ++++ + R  L  + C  +RFQ      +
Sbjct: 268 DFANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSN 325

Query: 341 RWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQ--TLGQNDTGF 398
           +W Y G  D I+F V++R+ I GFGLYGS  G  +Y   I++    K+Q   LGQN + +
Sbjct: 326 QWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIEL----KRQGVVLGQNLSKY 381

Query: 399 SCDGTANTFRVMFKEPIEILPNVCYTACATLKGPD-SHYGTKGLKKVVHETPAASKTVFF 457
             DG++NTF V F+ P++I P+  YTA   L G + S++G +G+ +V        K    
Sbjct: 382 FSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEV-----QCGKVTVQ 436

Query: 458 FFSSPGNNNGTSIEDGQIPEIIFY 481
           F  S  + NGT ++ GQIPE+IFY
Sbjct: 437 FQCSSDSTNGTGVQGGQIPELIFY 460


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  102 bits (255), Expect = 6e-22
 Identities = 69/244 (28%), Positives = 119/244 (48%), Gaps = 18/244 (7%)

Query: 88  QRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPE 146
           ++IPAHR VLAA S  F+ MF   M  + S E+EL D EP     L+ F Y+  + +   
Sbjct: 53  RKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 112

Query: 147 TVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKS 206
            V + L  A +Y +  ++  CV+FL + + A N   +   A   D P+L +   D I + 
Sbjct: 113 NVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQH 172

Query: 207 TMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPVTFGNKQ 265
             +    + F  +D+  +  +L +DTL++R E +++ A VRW         L     N+Q
Sbjct: 173 FTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW---------LKYDEPNRQ 223

Query: 266 KVLGKALSLIRFPLMTIEEFAAGPAQSGILSD-----REVVNLFLHFTVNPKPRVEYID- 319
             +   L+ +RFPL++    +       ++ D     + V++   +  ++P+ R E +D 
Sbjct: 224 PFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDG 283

Query: 320 -RPR 322
            RPR
Sbjct: 284 TRPR 287


>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
          Length = 564

 Score =  102 bits (255), Expect = 6e-22
 Identities = 69/244 (28%), Positives = 119/244 (48%), Gaps = 18/244 (7%)

Query: 88  QRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPE 146
           ++IPAHR VLAA S  F+ MF   M  + S E+EL D EP     L+ F Y+  + +   
Sbjct: 31  RKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 90

Query: 147 TVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKS 206
            V + L  A +Y +  ++  CV+FL + + A N   +   A   D P+L +   D I + 
Sbjct: 91  NVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQH 150

Query: 207 TMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPVTFGNKQ 265
             +    + F  +D+  +  +L +DTL++R E +++ A VRW         L     N+Q
Sbjct: 151 FTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW---------LKYDEPNRQ 201

Query: 266 KVLGKALSLIRFPLMTIEEFAAGPAQSGILSD-----REVVNLFLHFTVNPKPRVEYID- 319
             +   L+ +RFPL++    +       ++ D     + V++   +  ++P+ R E +D 
Sbjct: 202 PFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDG 261

Query: 320 -RPR 322
            RPR
Sbjct: 262 TRPR 265


>gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
          Length = 612

 Score =  101 bits (252), Expect = 1e-21
 Identities = 71/253 (28%), Positives = 114/253 (45%), Gaps = 27/253 (10%)

Query: 55  LKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMAT 114
           L E    L   E   DV FV+ K          +R PAHR +LAA    F A+  GGM  
Sbjct: 22  LSEHIGALLIGEEYGDVTFVVEK----------KRFPAHRVILAARCQYFRALLYGGMRE 71

Query: 115 TSAEIELP--DVEPAAFLALLRFLYSDEVQIGPE---TVMTTLYTAKKYAVPALEAHCVE 169
           +  E E+P  D    AF  LL+++Y+    +  E    ++  L  A KY  P LE    E
Sbjct: 72  SQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSE 131

Query: 170 FLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLE 229
           +L   L   N  M    A L+  P+L  +C   +D++  + +S+EGF  +    L  ++ 
Sbjct: 132 YLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVL 191

Query: 230 RDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGP 289
           RD+ +  E  +F A++ W +             N ++   + +  +R PLM++ E     
Sbjct: 192 RDSFAAPEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVV 239

Query: 290 AQSGILSDREVVN 302
             SG+LS   +++
Sbjct: 240 RPSGLLSPDAILD 252


>gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
          Length = 612

 Score =  101 bits (252), Expect = 1e-21
 Identities = 71/253 (28%), Positives = 114/253 (45%), Gaps = 27/253 (10%)

Query: 55  LKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMAT 114
           L E    L   E   DV FV+ K          +R PAHR +LAA    F A+  GGM  
Sbjct: 22  LSEHIGALLIGEEYGDVTFVVEK----------KRFPAHRVILAARCQYFRALLYGGMRE 71

Query: 115 TSAEIELP--DVEPAAFLALLRFLYSDEVQIGPE---TVMTTLYTAKKYAVPALEAHCVE 169
           +  E E+P  D    AF  LL+++Y+    +  E    ++  L  A KY  P LE    E
Sbjct: 72  SQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSE 131

Query: 170 FLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLE 229
           +L   L   N  M    A L+  P+L  +C   +D++  + +S+EGF  +    L  ++ 
Sbjct: 132 YLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVL 191

Query: 230 RDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGP 289
           RD+ +  E  +F A++ W +             N ++   + +  +R PLM++ E     
Sbjct: 192 RDSFAAPEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVV 239

Query: 290 AQSGILSDREVVN 302
             SG+LS   +++
Sbjct: 240 RPSGLLSPDAILD 252


>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
           sapiens]
          Length = 606

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 16/222 (7%)

Query: 66  ELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGM-ATTSAEIELPDV 124
           +LL + +F+           G + +P HR +L+A S  F   F   +      E+ L +V
Sbjct: 25  DLLDEKKFI-----DCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNV 79

Query: 125 EPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLL 184
           +PA    ++++LYS  + +    V      A ++ +P++   CV +L K L   N   +L
Sbjct: 80  DPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAIL 139

Query: 185 TQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGA 243
               L D P+LA    + +    +     E F  +    L +V+  D+L++ +E  +F A
Sbjct: 140 RLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEA 199

Query: 244 VVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEF 285
           V++W   + +         N+ K L +    IRF LMT + F
Sbjct: 200 VMKWVRTDKE---------NRVKNLSEVFDCIRFRLMTEKYF 232


>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
           sapiens]
          Length = 621

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 58/193 (30%), Positives = 86/193 (44%), Gaps = 8/193 (4%)

Query: 76  GKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRF 135
           GK        G +  P HR VLAA S  F A F       + E+ L +V P     +L +
Sbjct: 30  GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE-PERAGELHLEEVSPDVVAQVLHY 88

Query: 136 LYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQL 195
           LY+ E+ +   +V      A ++ +P++   CV FL K L   N   +     L D  +L
Sbjct: 89  LYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARL 148

Query: 196 ASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRW-----AE 249
           A    D I            F  +  D L A++  D L++ +E  +F AV+RW     AE
Sbjct: 149 AVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAE 208

Query: 250 AECQRQQ-LPVTF 261
           A+ +RQ+ LP  F
Sbjct: 209 AQAERQRALPTVF 221


>gi|211904190 hypothetical protein LOC149478 [Homo sapiens]
          Length = 291

 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 63/227 (27%), Positives = 99/227 (43%), Gaps = 14/227 (6%)

Query: 62  LFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMAT-TSAEIE 120
           L N+   SDV FV+G+ R        Q + AHR +LA     F  +          + + 
Sbjct: 22  LVNNPRYSDVCFVVGQER--------QEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVV 73

Query: 121 LPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNA 180
           L  V   AFLA+L FLY++ V++   +V+  L  A +Y +  L   C++F+ K L  D  
Sbjct: 74  LSTVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQFVVKVLDVDLV 133

Query: 181 FMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRL 240
              L  A  F   QL   C+  I+  + +A+   GF ++    L  +L  D L + E+ L
Sbjct: 134 CEALQVAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDEAEL 193

Query: 241 FGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAA 287
             A   WA       + PV      +V    +  +R  L+   E +A
Sbjct: 194 VRAARSWARVGAAVLERPVA-----EVAAPVVKELRLALLAPAELSA 235


>gi|151108435 BTB (POZ) domain containing 9 isoform b [Homo sapiens]
          Length = 544

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 50/189 (26%), Positives = 87/189 (46%), Gaps = 15/189 (7%)

Query: 117 AEIELPDVEPAAFLALLRFLYSDEVQIGPE---TVMTTLYTAKKYAVPALEAHCVEFLTK 173
           AEI L D    AF  LL+++Y+    +  E    ++  L  A KY  P LE    E+L  
Sbjct: 8   AEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCT 67

Query: 174 HLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTL 233
            L   N  M    A L+  P+L  +C   +D++  + +S+EGF  +    L  ++ RD+ 
Sbjct: 68  ILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSF 127

Query: 234 SIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSG 293
           +  E  +F A++ W +             N ++   + +  +R PLM++ E       SG
Sbjct: 128 AAPEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSG 175

Query: 294 ILSDREVVN 302
           +LS   +++
Sbjct: 176 LLSPDAILD 184


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 52/218 (23%), Positives = 97/218 (44%), Gaps = 11/218 (5%)

Query: 90  IPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETV 148
           I AHR VLAA S  F AMF G M+ + A+ IE+ DV+      L+ ++Y+ E+++  E V
Sbjct: 61  IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV 120

Query: 149 MTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTM 208
              L  A    +  +  +C +FL   L   N   +   A +     L        ++   
Sbjct: 121 QVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 180

Query: 209 DAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAECQRQQLPVTFGNKQKV 267
           + +  E F  + +D +C+++  D L++  E ++F AV+ W   E +          + + 
Sbjct: 181 EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKE---------TRLEH 231

Query: 268 LGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFL 305
           + K +  +R PL+  +       +  ++ +      FL
Sbjct: 232 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFL 269


>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
          Length = 601

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 50/192 (26%), Positives = 88/192 (45%), Gaps = 14/192 (7%)

Query: 93  HRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTT 151
           HR VLAA S  F +MF  G+  +T  E+ +  VE  +   +L + Y+  V +    V   
Sbjct: 64  HRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQAL 123

Query: 152 LYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAI 211
              A  + +P+++  C +++  HL   N+  +   A  +   +L     + I K  +   
Sbjct: 124 FTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVT 183

Query: 212 SAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAECQRQQ--LPVTFGNKQKVL 268
             + F  +  D L ++L+ D L++ RE  ++ +++RW E E   ++  LP  F       
Sbjct: 184 KEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFA------ 237

Query: 269 GKALSLIRFPLM 280
                 IRFPLM
Sbjct: 238 ----KCIRFPLM 245


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 67/271 (24%), Positives = 115/271 (42%), Gaps = 33/271 (12%)

Query: 25  PPPPPSPSSLGPLLPLQREP----------LYNWQATKASLKERFAFLFNSELLSDVRFV 74
           PP PP+ +  G   PL  +           +  W   KA   +    L +  LL DV  V
Sbjct: 4   PPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAF--KVMNELRSQNLLCDVTIV 61

Query: 75  LGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALL 133
                          I AHR VLAA S  F AMF G M+ + A+ + + +V+      L+
Sbjct: 62  ----------AEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLI 111

Query: 134 RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEP 193
            ++Y+ E+Q+  E V   L  A    +  ++  C EFL   L   N   +   A +    
Sbjct: 112 DYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACT 171

Query: 194 QLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAEC 252
            L +      ++   D + +E F ++ I+ +C+++  D L+I  E ++F AV+ W   + 
Sbjct: 172 DLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 231

Query: 253 QRQQLPVTFGNKQKVLGKALSLIRFPLMTIE 283
                      +Q+ + + +  +R PL+  E
Sbjct: 232 D---------VRQEFMARLMEHVRLPLLPRE 253


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 51/196 (26%), Positives = 93/196 (47%), Gaps = 11/196 (5%)

Query: 90  IPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETV 148
           I AHR VLAA S  F AMF G M+ + A+ + + +V+      L+ ++Y+ E+Q+  E V
Sbjct: 71  ISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENV 130

Query: 149 MTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTM 208
              L  A    +  ++  C EFL   L   N   +   A +     L +      ++   
Sbjct: 131 QVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFA 190

Query: 209 DAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAECQRQQLPVTFGNKQKV 267
           D + +E F ++ I+ +C+++  D L+I  E ++F AV+ W   +            +Q+ 
Sbjct: 191 DVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD---------VRQEF 241

Query: 268 LGKALSLIRFPLMTIE 283
           + + +  +R PL+  E
Sbjct: 242 MARLMEHVRLPLLPRE 257


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 19/226 (8%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIG 144
           G  RIPAHR VL+A S  F AMF N  +     E+ +  V+P A  +L+++ Y+  +Q+ 
Sbjct: 189 GHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLK 248

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTID 204
            +T+ + L  A    +  +   C  FL K L   N   +    R F + Q  +  L+   
Sbjct: 249 EDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGI----RSFGDAQGCTELLNVAH 304

Query: 205 KSTM----DAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAECQRQQLPV 259
           K TM    + I  + F  +  + +  +L  D +++  E  +F A+++W   + Q      
Sbjct: 305 KYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQ------ 358

Query: 260 TFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFL 305
              N+Q  LG  LS IR PL+  +  A     S    D E   L +
Sbjct: 359 ---NRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLM 401


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 63/226 (27%), Positives = 102/226 (45%), Gaps = 19/226 (8%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIG 144
           G  RIPAHR VL+A S  F AMF N  +     E+ +  V+P A  +L+++ Y+  +Q+ 
Sbjct: 189 GHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLK 248

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTID 204
            +T+ + L  A    +  +   C  FL K L   N   +    R F + Q  +  L+   
Sbjct: 249 EDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGI----RSFGDAQGCTELLNVAH 304

Query: 205 KSTM----DAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAECQRQQLPV 259
           K TM    + I  + F  +  + +  +L  D +++  E  +F A+++W   + Q      
Sbjct: 305 KYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQ------ 358

Query: 260 TFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSDREVVNLFL 305
              N+Q  LG  LS IR PL+  +  A     S    D E   L +
Sbjct: 359 ---NRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLM 401


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 64/228 (28%), Positives = 104/228 (45%), Gaps = 26/228 (11%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIG 144
           G ++I AHR +L+A S  F AMF G +A +   E+ + D++  A   L+ F Y+ ++ + 
Sbjct: 75  GAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVE 134

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTID 204
              V T L  A    +  ++  C EFL + L   N   +    R F +       L   D
Sbjct: 135 EGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGI----RAFADTHSCRELLRIAD 190

Query: 205 KST----MDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQ--RQQL 257
           K T     + + +E F  +  + L  ++  D L++R E ++F AV+ W +   Q  R QL
Sbjct: 191 KFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQL 250

Query: 258 PVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSG--ILSDREVVNL 303
           P           + L  +R PL++  +F  G   S   I SD E  +L
Sbjct: 251 P-----------QVLQHVRLPLLS-PKFLVGTVGSDPLIKSDEECRDL 286


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 2/170 (1%)

Query: 92  AHRFVLAAGSAVFDAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLYSDEVQIGPETVMT 150
           AH+ VLA+ S VF AMF  G+     E+  +  + P     L+ F Y+  + +G + V+ 
Sbjct: 95  AHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLH 154

Query: 151 TLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDA 210
            +  A  Y + ++   C +FL + L   NA  +   A      +L     + I     + 
Sbjct: 155 VMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEV 214

Query: 211 ISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPV 259
              E F ++    L  ++ RD L++R ES +F A + W + +C++++  V
Sbjct: 215 AKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYV 264


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 2/170 (1%)

Query: 92  AHRFVLAAGSAVFDAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLYSDEVQIGPETVMT 150
           AH+ VLA+ S VF AMF  G+     E+  +  + P     L+ F Y+  + +G + V+ 
Sbjct: 95  AHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLH 154

Query: 151 TLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDA 210
            +  A  Y + ++   C +FL + L   NA  +   A      +L     + I     + 
Sbjct: 155 VMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEV 214

Query: 211 ISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPV 259
              E F ++    L  ++ RD L++R ES +F A + W + +C++++  V
Sbjct: 215 AKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYV 264


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 64/252 (25%), Positives = 113/252 (44%), Gaps = 26/252 (10%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIG 144
           G  +  AHR VLAA    F AMF N  M     EI +  ++P+A  AL+ F Y+  + I 
Sbjct: 45  GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAID 104

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDT-- 202
            + V + L  A    + +++  C  FL + L   N        R F E  + ++  D   
Sbjct: 105 QQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL----GVRQFAETMMCAVLYDAAN 160

Query: 203 --IDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPV 259
             I +  ++   +E F  + ++ +  ++ RD L+++ E ++F A + W   +  R+Q   
Sbjct: 161 SFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYD--REQ--- 215

Query: 260 TFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQSGIL----SDREVVNLFLHFTVNPKPRV 315
               +   L + LS IR PL   +  +    Q  ++      R++V+    + + P+ R 
Sbjct: 216 ----RGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRP 271

Query: 316 E---YIDRPRCC 324
               +  RPRCC
Sbjct: 272 HLPAFRTRPRCC 283


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 71/290 (24%), Positives = 118/290 (40%), Gaps = 28/290 (9%)

Query: 9   AGEQASGAEAEPGP---AGPPPPPSPSS--LGPLLPLQREPLYNWQ-ATKASLKERFAFL 62
           AG   S     PGP   A PPPPP P +       P Q  P    + A +   +E  +  
Sbjct: 9   AGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVA 68

Query: 63  FNSELLSDVRFVLG---KGRGAAAA----GGPQRIPAHRFVLAAGSAVFDAMFNGGMATT 115
            NS+      FV     + RG           + I AH+ VLA+ S  F AMF   M+ +
Sbjct: 69  HNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSES 128

Query: 116 -SAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKH 174
               + L D++P A   L++F Y+ E+ +G   V T L  A    +  +   C +FL   
Sbjct: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188

Query: 175 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLS 234
           L   N   +   A       L       + +  +D    E F  + +  +  ++  D+L+
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248

Query: 235 I-RESRLFGAVVRWA--EAECQRQQLPVTFGNKQKVLGKALSLIRFPLMT 281
           +  E  ++ AV+ W   + + +RQ +P           + +  +R PL++
Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVP-----------RLMKCVRLPLLS 287


>gi|126116565 MYC binding protein 2 [Homo sapiens]
          Length = 4640

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 48/159 (30%), Positives = 74/159 (46%), Gaps = 18/159 (11%)

Query: 332  INRFQQVESRWGYSGTS-DRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKK-- 388
            +NRF+     WGYS  S + IRF+ +  I + G GL+G   G  +Y   I++ E      
Sbjct: 1196 VNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFG---GRGEYTAKIKLFELGPDGG 1252

Query: 389  ------QTLGQNDT-GFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGL 441
                    L + D   + C      + +MF EP+ +     Y A A + GP S  G+ G 
Sbjct: 1253 DHETDGDLLAETDVLAYDC-AAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQ 1311

Query: 442  KKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIF 480
              +  +       VF F SS  +NNGT +  GQIP++++
Sbjct: 1312 ASITTD----DGVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346



 Score = 36.6 bits (83), Expect = 0.052
 Identities = 38/171 (22%), Positives = 70/171 (40%), Gaps = 19/171 (11%)

Query: 325  LRGKECCINRFQQVESRWGYS---GTSDRIRFTVNRR-ISIVGFGLYGSIHGPTDYQVNI 380
            L   +   NRF +      ++   G+ D I F+V++  I +VGF +YG   G  +Y++ +
Sbjct: 1680 LHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGG-GGIHEYELEV 1738

Query: 381  QIIEYEKKQTLGQNDTGFSCDGTANTF----------RVMFKEPIEILPNVCYTACATLK 430
             + + E       +    S +    T+           +   + + +  NV Y       
Sbjct: 1739 LVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNY 1798

Query: 431  GPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIFY 481
            G  +  G  G+  V           F F +   ++NGT+   GQIP+I++Y
Sbjct: 1799 GSRTANGDGGMTTV----QCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYY 1845


>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
           [Homo sapiens]
          Length = 584

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 55/197 (27%), Positives = 86/197 (43%), Gaps = 11/197 (5%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIG 144
           G +   AHR VLAA S  F A+F GGM  +S + + +  +E   F  LL F+Y+  V IG
Sbjct: 44  GQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIG 103

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTID 204
              V   +  A    +  +   C EFL   +   N   +   +       L     + I 
Sbjct: 104 VNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIH 163

Query: 205 KSTMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPVTFGN 263
              ++  S E F  +  D L  +L  + LSI  E ++F A ++W   +          G 
Sbjct: 164 VHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKD---------LGK 214

Query: 264 KQKVLGKALSLIRFPLM 280
           ++K + + L  IRFPL+
Sbjct: 215 RRKHVVEVLDPIRFPLL 231


>gi|223890235 intracisternal A particle-promoted polypeptide isoform
           2 [Homo sapiens]
          Length = 582

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 55/197 (27%), Positives = 86/197 (43%), Gaps = 11/197 (5%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIG 144
           G +   AHR VLAA S  F A+F GGM  +S + + +  +E   F  LL F+Y+  V IG
Sbjct: 44  GQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIG 103

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTID 204
              V   +  A    +  +   C EFL   +   N   +   +       L     + I 
Sbjct: 104 VNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIH 163

Query: 205 KSTMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQQLPVTFGN 263
              ++  S E F  +  D L  +L  + LSI  E ++F A ++W   +          G 
Sbjct: 164 VHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKD---------LGK 214

Query: 264 KQKVLGKALSLIRFPLM 280
           ++K + + L  IRFPL+
Sbjct: 215 RRKHVVEVLDPIRFPLL 231


>gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo
           sapiens]
          Length = 684

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 59/214 (27%), Positives = 91/214 (42%), Gaps = 11/214 (5%)

Query: 50  ATKASLKERFAFLFNSELLSDVRF-VLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMF 108
           A  A+L  +    +++ LL DV   V+  G G    G  +    +R VLAA    F +MF
Sbjct: 44  AHSAALLAQLKSFYDARLLCDVTIEVVTPGSGP---GTGRLFSCNRNVLAAACPYFKSMF 100

Query: 109 NGGM-ATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHC 167
            GGM  +  A + + DV+  +F  L+ + Y+  V +    V      +    +  +   C
Sbjct: 101 TGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160

Query: 168 VEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTI-----DKSTMDAISAEGFTDIDID 222
             FL + L   N   +L  A  FD  +L S     I       S M +I  E   D+ + 
Sbjct: 161 ASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLA 220

Query: 223 TLCAVLERDTLSIRESR-LFGAVVRWAEAECQRQ 255
            L AVL  D+L I   R +    V+W EA  + +
Sbjct: 221 QLLAVLRLDSLDIESERTVCHVAVQWLEAAAKER 254


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 58/248 (23%), Positives = 109/248 (43%), Gaps = 19/248 (7%)

Query: 86  GPQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIG 144
           G  +I AH+ VLA+ S  F AMF G ++   ++E+E   ++  A  A++ + Y+  V I 
Sbjct: 42  GDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFIS 101

Query: 145 PETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTID 204
            +TV + L  A    +  +   C  FL   L   N   +   A  +    L       I 
Sbjct: 102 QDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYIC 161

Query: 205 KSTMDAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVRWAEAECQRQQLPVTFGN 263
           ++       E F ++    L  ++  D L++  E  +F A+  W + + Q          
Sbjct: 162 QNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQ---------E 212

Query: 264 KQKVLGKALSLIRFPLMTIEEFAAGPAQSGILSD----REVVNLFLHFTVNPKPRVEY-- 317
           +QK L + L+ +R PL++++        + ++ D    + ++N  L +   P+ R+ +  
Sbjct: 213 RQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQT 272

Query: 318 --IDRPRC 323
             + RPRC
Sbjct: 273 VLMTRPRC 280


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,057,839
Number of Sequences: 37866
Number of extensions: 983675
Number of successful extensions: 15130
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 12009
Number of HSP's gapped (non-prelim): 2853
length of query: 482
length of database: 18,247,518
effective HSP length: 106
effective length of query: 376
effective length of database: 14,233,722
effective search space: 5351879472
effective search space used: 5351879472
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.