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Search of human proteins with 13376725
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13376725 coiled-coil domain containing 92 [Homo sapiens]
(331 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13376725 coiled-coil domain containing 92 [Homo sapiens] 652 0.0
gi|239756693 PREDICTED: similar to coiled-coil domain containing... 113 2e-25
gi|169211642 PREDICTED: hypothetical protein [Homo sapiens] 96 6e-20
gi|169210857 PREDICTED: similar to RIKEN cDNA E130309D14 [Homo s... 96 6e-20
gi|110611218 ribosome binding protein 1 [Homo sapiens] 52 6e-07
gi|110611220 ribosome binding protein 1 [Homo sapiens] 52 6e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 50 3e-06
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 49 5e-06
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 49 5e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 47 3e-05
gi|151101140 coiled-coil domain containing 2 isoform a [Homo sap... 46 4e-05
gi|151105223 coiled-coil domain containing 2 isoform a [Homo sap... 46 4e-05
gi|151105229 coiled-coil domain containing 2 isoform a [Homo sap... 46 4e-05
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 44 2e-04
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 44 2e-04
gi|21735548 centrosomal protein 2 [Homo sapiens] 44 2e-04
gi|38044112 restin isoform b [Homo sapiens] 43 3e-04
gi|4506751 restin isoform a [Homo sapiens] 43 3e-04
gi|187761317 tet oncogene family member 2 isoform a [Homo sapiens] 43 4e-04
gi|27894337 keratin 20 [Homo sapiens] 43 4e-04
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 43 4e-04
gi|46249351 homer 2 isoform 2 [Homo sapiens] 43 4e-04
gi|46249349 homer 2 isoform 1 [Homo sapiens] 43 4e-04
gi|214010216 SMC6 protein [Homo sapiens] 43 4e-04
gi|13375848 SMC6 protein [Homo sapiens] 43 4e-04
gi|46409266 coiled-coil domain containing 74B [Homo sapiens] 43 4e-04
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 42 6e-04
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 42 6e-04
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 42 6e-04
gi|131412228 keratin 13 isoform b [Homo sapiens] 42 6e-04
>gi|13376725 coiled-coil domain containing 92 [Homo sapiens]
Length = 331
Score = 652 bits (1681), Expect = 0.0
Identities = 331/331 (100%), Positives = 331/331 (100%)
Query: 1 MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT 60
MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT
Sbjct: 1 MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT 60
Query: 61 DLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLE 120
DLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLE
Sbjct: 61 DLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLE 120
Query: 121 NTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASP 180
NTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASP
Sbjct: 121 NTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASP 180
Query: 181 SGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAM 240
SGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAM
Sbjct: 181 SGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAM 240
Query: 241 PDPTPFLLARESAEVHLIKERPLVIPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHATP 300
PDPTPFLLARESAEVHLIKERPLVIPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHATP
Sbjct: 241 PDPTPFLLARESAEVHLIKERPLVIPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHATP 300
Query: 301 PQAQPEVKTLAVDQVNGGKVVRKHSGTDRTV 331
PQAQPEVKTLAVDQVNGGKVVRKHSGTDRTV
Sbjct: 301 PQAQPEVKTLAVDQVNGGKVVRKHSGTDRTV 331
>gi|239756693 PREDICTED: similar to coiled-coil domain containing 92
[Homo sapiens]
Length = 272
Score = 113 bits (283), Expect = 2e-25
Identities = 58/167 (34%), Positives = 104/167 (62%), Gaps = 18/167 (10%)
Query: 16 VSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTG 75
V+M +LE+Q+ S Q+++ FL++E + L+ LH EI RLQ+ C++
Sbjct: 17 VAMDTVSLEHQIQSVQRHISFLKKEQMALLRDLHLEILRLQKRCSE-------------- 62
Query: 76 DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELK 135
+ S EL+ +C LE+QL+ + NAEL +E+ Q+ A+++ L +++ E+++LEEL+
Sbjct: 63 ---AASRELESKCRALESQLEARAAANAELRREVAQREALVSALRCSLRTEERRFLEELR 119
Query: 136 AKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMS-SSGTSDASPS 181
+SH+ T+L +EL++ AYL+ QLHAA+++L + G + A P+
Sbjct: 120 RRSHRATVLGTELQKHTEAAAYLSCQLHAARQRLQAPRPGPARAQPA 166
>gi|169211642 PREDICTED: hypothetical protein [Homo sapiens]
Length = 378
Score = 95.5 bits (236), Expect = 6e-20
Identities = 47/148 (31%), Positives = 91/148 (61%), Gaps = 4/148 (2%)
Query: 60 TDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVL 119
T+LT++L ++ + Q+ + S EL+ +C LE+QL+ + NAEL +E+ Q+ A+++ L
Sbjct: 133 TELTHDLEMREA-QSHQQEAASRELESKCRALESQLEARAAANAELRREVAQREALVSAL 191
Query: 120 ENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDAS 179
+++ E+++LEEL+ +SH+ T+L +EL++ AYL+ QLHAA+++L +++
Sbjct: 192 RCSLRTEERRFLEELRRRSHRATVLGTELQKHTEAAAYLSCQLHAARQRLQAAAA---QR 248
Query: 180 PSGSPVLASYKPAPPKDKLPETPRRRMK 207
P +P + P P + P +R +
Sbjct: 249 PQPAPAASPGAPGPSRPAARAQPAQRAR 276
Score = 42.0 bits (97), Expect = 8e-04
Identities = 18/43 (41%), Positives = 30/43 (69%)
Query: 18 MAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT 60
M +LE+Q+ S Q+++ FL++E + L+ LH EI RLQ+ C+
Sbjct: 1 MDTVSLEHQIQSVQRHISFLKKEQMALLRDLHLEILRLQKRCS 43
>gi|169210857 PREDICTED: similar to RIKEN cDNA E130309D14 [Homo
sapiens]
Length = 378
Score = 95.5 bits (236), Expect = 6e-20
Identities = 47/148 (31%), Positives = 91/148 (61%), Gaps = 4/148 (2%)
Query: 60 TDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVL 119
T+LT++L ++ + Q+ + S EL+ +C LE+QL+ + NAEL +E+ Q+ A+++ L
Sbjct: 133 TELTHDLEMREA-QSHQQEAASRELESKCRALESQLEARAAANAELRREVAQREALVSAL 191
Query: 120 ENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDAS 179
+++ E+++LEEL+ +SH+ T+L +EL++ AYL+ QLHAA+++L +++
Sbjct: 192 RCSLRTEERRFLEELRRRSHRATVLGTELQKHTEAAAYLSCQLHAARQRLQAAAA---QR 248
Query: 180 PSGSPVLASYKPAPPKDKLPETPRRRMK 207
P +P + P P + P +R +
Sbjct: 249 PQPAPAASPGAPGPSRPAARAQPAQRAR 276
Score = 42.0 bits (97), Expect = 8e-04
Identities = 18/43 (41%), Positives = 30/43 (69%)
Query: 18 MAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT 60
M +LE+Q+ S Q+++ FL++E + L+ LH EI RLQ+ C+
Sbjct: 1 MDTVSLEHQIQSVQRHISFLKKEQMALLRDLHLEILRLQKRCS 43
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 52.4 bits (124), Expect = 6e-07
Identities = 65/299 (21%), Positives = 114/299 (38%), Gaps = 31/299 (10%)
Query: 26 QLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELT----------VKSSEQTG 75
+LHS ++ R L GLH +++ + + LT + + ++
Sbjct: 484 ELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQ 543
Query: 76 DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEEL- 134
+++ + + R +ELE+Q+ E E EL + +EQ+ V N ++E+ K +E L
Sbjct: 544 ASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQK----VKNNDLREKNWKAMEALA 599
Query: 135 ------KAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMS-------SSGTSDASPS 181
K K H LT E E++ I T + A +S + D
Sbjct: 600 TAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEK 659
Query: 182 GSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAMP 241
G P L + PAP + + R + + L E ++ AE+ +L
Sbjct: 660 G-PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEE 718
Query: 242 DPTPFLLARESAEVHLIKERPLV--IPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHA 298
+ + +AE L K R V + I GE S + + H +H+ H A
Sbjct: 719 EEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMA 777
Score = 32.7 bits (73), Expect = 0.46
Identities = 35/149 (23%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 24 ENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE 83
E ++ + Q + REH ++ L +IR LQ+ +L + Q ++S
Sbjct: 319 EQEITAVQARMQASYREHVKEVQQLQGKIRTLQE-------QLENGPNTQLARLQQENSI 371
Query: 84 LKKRCEELEAQLKVKEN-ENAELLKELEQKNAMITVLENTIK--EREKKYLEELKAKSHK 140
L+ + +Q++ K+N E A+L +EL + + + ++ E+++K L E KA + +
Sbjct: 372 LRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL-EAKAAAFE 430
Query: 141 LTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+L + R S A L +L ++L
Sbjct: 431 KQVLQLQASHRESEEA-LQKRLDEVSREL 458
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 52.4 bits (124), Expect = 6e-07
Identities = 65/299 (21%), Positives = 114/299 (38%), Gaps = 31/299 (10%)
Query: 26 QLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELT----------VKSSEQTG 75
+LHS ++ R L GLH +++ + + LT + + ++
Sbjct: 484 ELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQ 543
Query: 76 DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEEL- 134
+++ + + R +ELE+Q+ E E EL + +EQ+ V N ++E+ K +E L
Sbjct: 544 ASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQK----VKNNDLREKNWKAMEALA 599
Query: 135 ------KAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMS-------SSGTSDASPS 181
K K H LT E E++ I T + A +S + D
Sbjct: 600 TAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEK 659
Query: 182 GSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAESRKLLLREPVDAMP 241
G P L + PAP + + R + + L E ++ AE+ +L
Sbjct: 660 G-PTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEE 718
Query: 242 DPTPFLLARESAEVHLIKERPLV--IPPIASDRSGEQHSPAREKPHKAHVGVAHRIHHA 298
+ + +AE L K R V + I GE S + + H +H+ H A
Sbjct: 719 EEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMA 777
Score = 32.7 bits (73), Expect = 0.46
Identities = 35/149 (23%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 24 ENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE 83
E ++ + Q + REH ++ L +IR LQ+ +L + Q ++S
Sbjct: 319 EQEITAVQARMQASYREHVKEVQQLQGKIRTLQE-------QLENGPNTQLARLQQENSI 371
Query: 84 LKKRCEELEAQLKVKEN-ENAELLKELEQKNAMITVLENTIK--EREKKYLEELKAKSHK 140
L+ + +Q++ K+N E A+L +EL + + + ++ E+++K L E KA + +
Sbjct: 372 LRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL-EAKAAAFE 430
Query: 141 LTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+L + R S A L +L ++L
Sbjct: 431 KQVLQLQASHRESEEA-LQKRLDEVSREL 458
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 50.1 bits (118), Expect = 3e-06
Identities = 47/166 (28%), Positives = 86/166 (51%), Gaps = 20/166 (12%)
Query: 22 NLENQLHSAQKNLLFLQREHAST---LKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGT 78
NL+ QL ++ L H +T LK EI L+QH +++ ++ +SS++TG G
Sbjct: 868 NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
Query: 79 SKSSELKKRCEELEAQLKVKE---NENAELLK----ELEQKNAMITVLENTIKEREKKYL 131
+ K+ ++L +QL+ E N+ E LK +EQ AM+T LE ++ +EK+
Sbjct: 928 PSN---KEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL-NKEKQVT 983
Query: 132 EELKAKSHKLTLLSS-----ELEQRASTIAYLTSQLHAAKKKLMSS 172
EE++ K+ ++ L S +LE++ + +L K++ + S
Sbjct: 984 EEVR-KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIES 1028
Score = 37.4 bits (85), Expect = 0.019
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 36/193 (18%)
Query: 21 TNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQ-------------------HCTD 61
T + +L + +++L+ + L+ L +++RL + +D
Sbjct: 114 TRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASD 173
Query: 62 LTYELTVKSSEQTGD-----GTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMI 116
++ + K EQ + T ++ELK + +EL A + K NE EL LE K +
Sbjct: 174 VSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEV 233
Query: 117 TVLE------NTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLM 170
+ LE T E +K++E+L LT L EQ+AS ++L+A K
Sbjct: 234 SRLEEQMNGLKTSNEHLQKHVEDL------LTKLKEAKEQQASMEEKFHNELNAHIKLSN 287
Query: 171 SSSGTSDASPSGS 183
+D S + S
Sbjct: 288 LYKSAADDSEAKS 300
Score = 33.5 bits (75), Expect = 0.27
Identities = 39/176 (22%), Positives = 74/176 (42%), Gaps = 22/176 (12%)
Query: 15 DVSMAATNLENQLHSAQKNLLFLQRE---HASTLKGLHSEIRRL-------QQHCTDLTY 64
D+ T + QL A K LQ + + LH ++L +Q +T
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 65 ELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMIT------- 117
+L ++E+ ++ LKK E L+ + LL E +N ++T
Sbjct: 766 DLR-GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG 824
Query: 118 VLENTIKEREKKYLEELKAKSHKLTLL----SSELEQRASTIAYLTSQLHAAKKKL 169
+LE + E +++ +++ H+++ L +E+EQR + L QL K++L
Sbjct: 825 ILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
Score = 32.0 bits (71), Expect = 0.78
Identities = 38/162 (23%), Positives = 69/162 (42%), Gaps = 8/162 (4%)
Query: 2 TSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTD 61
TS S+ P+ S A + L Q+ ++E A K + ++ +LQ+ TD
Sbjct: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD 706
Query: 62 LTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLEN 121
L + T K S Q + + L+ E ++ N +L +++ +I +
Sbjct: 707 LRSQNT-KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 122 TIK-EREKKYLEELKA---KSHKLTLLSSEL---EQRASTIA 156
++ EK + E++A K K L SE+ +QR S +A
Sbjct: 766 DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Score = 30.4 bits (67), Expect = 2.3
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 16/106 (15%)
Query: 83 ELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKERE-------------KK 129
E++KR + +L + E L ELE+ N + L KE E +
Sbjct: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
Query: 130 YLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGT 175
EEL+A+ L + L Q + YLT + +KL S+ T
Sbjct: 116 TKEELEAEKRDLIRTNERLSQE---LEYLTEDVKRLNEKLKESNTT 158
Score = 30.4 bits (67), Expect = 2.3
Identities = 38/154 (24%), Positives = 67/154 (43%), Gaps = 19/154 (12%)
Query: 23 LENQLHSAQKNLLFLQREHAST---LKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTS 79
+E +L +Q+ L+ RE S L+ L+++++ L T+ EL + +
Sbjct: 57 IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKAL----TEKNKELEIAQDRNI----A 108
Query: 80 KSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSH 139
S+ + EELEA+ + N L +ELE L +K +K L+E
Sbjct: 109 IQSQFTRTKEELEAEKRDLIRTNERLSQELE-------YLTEDVKRLNEK-LKESNTTKG 160
Query: 140 KLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSS 173
+L L EL+ ++ Y +L K+ L S +
Sbjct: 161 ELQLKLDELQASDVSVKYREKRLEQEKELLHSQN 194
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 49.3 bits (116), Expect = 5e-06
Identities = 51/173 (29%), Positives = 71/173 (41%), Gaps = 20/173 (11%)
Query: 22 NLENQLHSAQKNLLFLQREH------ASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTG 75
NL QL S +K L E+ +LK ++ +LQ +L E EQ
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE-----KEQLK 738
Query: 76 DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKERE------KK 129
G K+ E LE + + EN L K LE N I LE+ +++ E +K
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 130 YLEELKAKSHKLTLLSSE---LEQRASTIAYLTSQLHAAKKKLMSSSGTSDAS 179
LEELK S +L L E LEQ S + QL K+L + D +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Score = 37.0 bits (84), Expect = 0.024
Identities = 48/175 (27%), Positives = 82/175 (46%), Gaps = 31/175 (17%)
Query: 14 LDVSMAATNLENQ-----LHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTV 68
L+VS ++ENQ L ++ K + L+ E L+ L E + LQ++ +L +++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESE----LQDLEMENQTLQKNLEEL--KISS 807
Query: 69 KSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIK---- 124
K EQ ++ L++ +LE K E EN L ++ E K+ T+ EN +K
Sbjct: 808 KRLEQL---EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT--TLEENNVKIGNL 862
Query: 125 EREKKYL-------EELKAKSHKLTLLSSELEQRAS----TIAYLTSQLHAAKKK 168
E+E K L +E + +L + EL +RA+ T+ L L + K K
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Score = 34.7 bits (78), Expect = 0.12
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 15/123 (12%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
LE Q ++ Q +L LQR+ S LQ+ T L + K + S+S+
Sbjct: 1072 LETQNNNLQAQILALQRQTVS-----------LQEQNTTLQTQ-NAKLQVENSTLNSQST 1119
Query: 83 ELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLT 142
L + +L Q ENEN ++KE E + ++ ++ IK+ EK L + S +
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKERED---LKSLYDSLIKDHEKLELLHERQASEYES 1176
Query: 143 LLS 145
L+S
Sbjct: 1177 LIS 1179
Score = 33.1 bits (74), Expect = 0.35
Identities = 38/153 (24%), Positives = 63/153 (41%), Gaps = 38/153 (24%)
Query: 39 REHAST-LKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKV 97
R+H S L ++IRRL+Q + T +L + K+ E++E +LK
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLL---------------DCKQELEQMEIELKR 290
Query: 98 KENENAELLKE-------------LEQKNAMITVLENTI---KER------EKKYLEELK 135
+ EN LL + L +K + LE+ + KER K +EELK
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 136 AKSHKLTLLSSELEQRASTIAYLTSQLHAAKKK 168
+ L + LE + + +LH +K+
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Score = 32.3 bits (72), Expect = 0.60
Identities = 26/130 (20%), Positives = 62/130 (47%), Gaps = 2/130 (1%)
Query: 41 HASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKEN 100
+AS + + E +RL + L E+ V+ + + + S +L K +LE ++
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEI-VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 101 ENAELLKELEQKNAMITVLENTIKEREKKYLE-ELKAKSHKLTLLSSELEQRASTIAYLT 159
+ +K LEQ+N + +++++R + E +K + +L +++ +S ++ +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 160 SQLHAAKKKL 169
+ KK+L
Sbjct: 608 FEKRQIKKEL 617
Score = 30.8 bits (68), Expect = 1.7
Identities = 35/134 (26%), Positives = 55/134 (41%), Gaps = 18/134 (13%)
Query: 29 SAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRC 88
SA+ + +++E+ K LH I+ + + +E Q E +R
Sbjct: 577 SAEARVKDIEKEN----KILHESIKETSSKLSKIEFE-----KRQIKKELEHYKEKGERA 627
Query: 89 EELEAQLKVKENENAELLKELEQKNAMITV-------LENTIKEREKKYLEELKAKSHKL 141
EELE +L E EN L K++ N IT EN+ ERE + L++ L
Sbjct: 628 EELENELHHLEKENELLQKKI--TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 142 TLLSSELEQRASTI 155
T LE+ S +
Sbjct: 686 TFQLESLEKENSQL 699
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 49.3 bits (116), Expect = 5e-06
Identities = 51/173 (29%), Positives = 71/173 (41%), Gaps = 20/173 (11%)
Query: 22 NLENQLHSAQKNLLFLQREH------ASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTG 75
NL QL S +K L E+ +LK ++ +LQ +L E EQ
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE-----KEQLK 738
Query: 76 DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKERE------KK 129
G K+ E LE + + EN L K LE N I LE+ +++ E +K
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 130 YLEELKAKSHKLTLLSSE---LEQRASTIAYLTSQLHAAKKKLMSSSGTSDAS 179
LEELK S +L L E LEQ S + QL K+L + D +
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Score = 37.0 bits (84), Expect = 0.024
Identities = 48/175 (27%), Positives = 82/175 (46%), Gaps = 31/175 (17%)
Query: 14 LDVSMAATNLENQ-----LHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTV 68
L+VS ++ENQ L ++ K + L+ E L+ L E + LQ++ +L +++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESE----LQDLEMENQTLQKNLEEL--KISS 807
Query: 69 KSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIK---- 124
K EQ ++ L++ +LE K E EN L ++ E K+ T+ EN +K
Sbjct: 808 KRLEQL---EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT--TLEENNVKIGNL 862
Query: 125 EREKKYL-------EELKAKSHKLTLLSSELEQRAS----TIAYLTSQLHAAKKK 168
E+E K L +E + +L + EL +RA+ T+ L L + K K
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Score = 34.7 bits (78), Expect = 0.12
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 15/123 (12%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
LE Q ++ Q +L LQR+ S LQ+ T L + K + S+S+
Sbjct: 1071 LETQNNNLQAQILALQRQTVS-----------LQEQNTTLQTQ-NAKLQVENSTLNSQST 1118
Query: 83 ELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLT 142
L + +L Q ENEN ++KE E + ++ ++ IK+ EK L + S +
Sbjct: 1119 SLMNQNAQLLIQQSSLENENESVIKERED---LKSLYDSLIKDHEKLELLHERQASEYES 1175
Query: 143 LLS 145
L+S
Sbjct: 1176 LIS 1178
Score = 33.1 bits (74), Expect = 0.35
Identities = 38/153 (24%), Positives = 63/153 (41%), Gaps = 38/153 (24%)
Query: 39 REHAST-LKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKV 97
R+H S L ++IRRL+Q + T +L + K+ E++E +LK
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLL---------------DCKQELEQMEIELKR 290
Query: 98 KENENAELLKE-------------LEQKNAMITVLENTI---KER------EKKYLEELK 135
+ EN LL + L +K + LE+ + KER K +EELK
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 136 AKSHKLTLLSSELEQRASTIAYLTSQLHAAKKK 168
+ L + LE + + +LH +K+
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Score = 32.3 bits (72), Expect = 0.60
Identities = 26/130 (20%), Positives = 62/130 (47%), Gaps = 2/130 (1%)
Query: 41 HASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKEN 100
+AS + + E +RL + L E+ V+ + + + S +L K +LE ++
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEI-VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 101 ENAELLKELEQKNAMITVLENTIKEREKKYLE-ELKAKSHKLTLLSSELEQRASTIAYLT 159
+ +K LEQ+N + +++++R + E +K + +L +++ +S ++ +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 160 SQLHAAKKKL 169
+ KK+L
Sbjct: 608 FEKRQIKKEL 617
Score = 30.8 bits (68), Expect = 1.7
Identities = 35/134 (26%), Positives = 55/134 (41%), Gaps = 18/134 (13%)
Query: 29 SAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRC 88
SA+ + +++E+ K LH I+ + + +E Q E +R
Sbjct: 577 SAEARVKDIEKEN----KILHESIKETSSKLSKIEFE-----KRQIKKELEHYKEKGERA 627
Query: 89 EELEAQLKVKENENAELLKELEQKNAMITV-------LENTIKEREKKYLEELKAKSHKL 141
EELE +L E EN L K++ N IT EN+ ERE + L++ L
Sbjct: 628 EELENELHHLEKENELLQKKI--TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 142 TLLSSELEQRASTI 155
T LE+ S +
Sbjct: 686 TFQLESLEKENSQL 699
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 46.6 bits (109), Expect = 3e-05
Identities = 33/159 (20%), Positives = 73/159 (45%), Gaps = 1/159 (0%)
Query: 14 LDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQ 73
LD+ L++QL +N L Q+E +L+ +L+ + +L +++
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL-IQAQNT 946
Query: 74 TGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEE 133
+ +L+ EL+ + K+ + L EL+ T LEN ++++ + +E
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006
Query: 134 LKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSS 172
L A+ K+++L + E+ T L S + + +L+++
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Score = 38.1 bits (87), Expect = 0.011
Identities = 53/204 (25%), Positives = 88/204 (43%), Gaps = 44/204 (21%)
Query: 1 MTSPHFSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCT 60
++S ++ D+ + + LE QL N LQ + T K H E + LQQ T
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT-KQQHQEQQALQQSTT 501
Query: 61 DLTYELTVKSSE---QTGDGTSKS--------------SELKKRCEELEAQLKVKENENA 103
E + Q GD K S L+K E+L A+++ E E A
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 104 ELLKELEQKNAMITVLENTIKEREKKYLEELK--AKSHKLT---LLSSELEQRA------ 152
+L +L++KN +T++E+ + E+LK ++SHK L EQ+A
Sbjct: 562 -VLNQLQEKN-------HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ 613
Query: 153 -------STIAYLTSQLHAAKKKL 169
+++ L SQL+ +K+K+
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKV 637
Score = 37.7 bits (86), Expect = 0.014
Identities = 40/146 (27%), Positives = 70/146 (47%), Gaps = 14/146 (9%)
Query: 28 HSAQKNLLFLQREHASTLK----GLHSEIRRLQQHCTDLTYELT----VKSSEQTGDG-- 77
H + NL L+R+ + L+ L + ++ + + +L EL ++ E DG
Sbjct: 72 HGGESNLA-LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLV 130
Query: 78 TSKSSELKKRCEELEAQLKVKENENAELLKEL-EQKNAMITVLENTIKEREKKYLEELKA 136
T S+EL+ ++LE EN N + +K+L EQK A + IK + + +A
Sbjct: 131 TDSSAELQSLEQQLEEAQT--ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 137 KSHKLTLLSSELEQRASTIAYLTSQL 162
K+T L+ EL + A+ I L ++L
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTEL 214
Score = 37.7 bits (86), Expect = 0.014
Identities = 49/188 (26%), Positives = 79/188 (42%), Gaps = 31/188 (16%)
Query: 5 HFSSYDEGPLDVSMAATNLENQLHSAQKNL------------LFLQREHASTLK--GLHS 50
H + + L + + L +QL+ +++ + L L E A T + L +
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 51 EIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELE 110
+ Q D EL K + Q T+K + ++ C +LE+ LK E E LE
Sbjct: 668 HLDTAQNALQDKQQELN-KITTQLDQVTAKLQDKQEHCSQLESHLK----EYKEKYLSLE 722
Query: 111 QKNAMITVLENTIKEREKKYLEELKAKSHKL------TLLSSELEQRASTIAYLTSQLHA 164
QK LE IK+ E LE +K L L+++LE RA+ L+ QL
Sbjct: 723 QKT---EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE---LSKQLEM 776
Query: 165 AKKKLMSS 172
K+ + S+
Sbjct: 777 EKEIVSST 784
Score = 37.0 bits (84), Expect = 0.024
Identities = 40/144 (27%), Positives = 71/144 (49%), Gaps = 6/144 (4%)
Query: 22 NLENQLHSAQKNLLFLQREH---ASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGT 78
+L+N L +AQ L Q+E + L + ++++ Q+HC+ L L + E+
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK-EYKEKYLSLE 722
Query: 79 SKSSELKKRCEELEA-QLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAK 137
K+ EL+ + ++LEA L+VK ++ + L++L+Q+ + T LE E K+ E +
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKE-QALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 138 SHKLTLLSSELEQRASTIAYLTSQ 161
S L + E S LT Q
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQ 805
Score = 33.9 bits (76), Expect = 0.21
Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 26/111 (23%)
Query: 46 KGLHSEIRRLQQHCTDLTYELTVKSSE---QTGDGTSKSSELKKRCEELEAQLKVKENEN 102
+ L +E+ ++ + ++ L SE + G + +L+K C+EL+ QL+V+
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ---- 904
Query: 103 AELLKELEQKNAMITVLENTIKERE--KKYLEELKAKSHKLTL-LSSELEQ 150
+ENT+KE++ KK LE+ K SH+L L L+S EQ
Sbjct: 905 ----------------MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Score = 29.3 bits (64), Expect = 5.1
Identities = 30/151 (19%), Positives = 63/151 (41%), Gaps = 12/151 (7%)
Query: 19 AATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGT 78
A L+ +L + L+ E K L + +QH L E+ S
Sbjct: 373 ATQKLKEELSEVETKYQHLKAE----FKQLQQQREEKEQHGLQLQSEINQLHS------- 421
Query: 79 SKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKS 138
K E +++ E +LK + ++E L + EQ+ A + + + ++E+ K+ +
Sbjct: 422 -KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 139 HKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
H+L + +++ + T++L A+ L
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
>gi|151101140 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 46.2 bits (108), Expect = 4e-05
Identities = 42/167 (25%), Positives = 77/167 (46%), Gaps = 20/167 (11%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
L Q+ + + ++R+ T + ++ I ++Q DL E G+ K
Sbjct: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL--------EEHQGEMNQKYK 359
Query: 83 ELKKRCEELEAQLKV-KENENAELLKELEQKNAMITVLE------NTIKEREKKYLEELK 135
ELKKR E ++ ++ +E +N EL ++ + + ++ +LE N I++ +ELK
Sbjct: 360 ELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELK 419
Query: 136 AKSHKLTLLSSELEQRASTIAYLTS-----QLHAAKKKLMSSSGTSD 177
L S+E+++ ST LTS QL K +L+ S T +
Sbjct: 420 MMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEE 466
>gi|151105223 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 46.2 bits (108), Expect = 4e-05
Identities = 42/167 (25%), Positives = 77/167 (46%), Gaps = 20/167 (11%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
L Q+ + + ++R+ T + ++ I ++Q DL E G+ K
Sbjct: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL--------EEHQGEMNQKYK 359
Query: 83 ELKKRCEELEAQLKV-KENENAELLKELEQKNAMITVLE------NTIKEREKKYLEELK 135
ELKKR E ++ ++ +E +N EL ++ + + ++ +LE N I++ +ELK
Sbjct: 360 ELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELK 419
Query: 136 AKSHKLTLLSSELEQRASTIAYLTS-----QLHAAKKKLMSSSGTSD 177
L S+E+++ ST LTS QL K +L+ S T +
Sbjct: 420 MMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEE 466
>gi|151105229 coiled-coil domain containing 2 isoform a [Homo
sapiens]
Length = 600
Score = 46.2 bits (108), Expect = 4e-05
Identities = 42/167 (25%), Positives = 77/167 (46%), Gaps = 20/167 (11%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
L Q+ + + ++R+ T + ++ I ++Q DL E G+ K
Sbjct: 308 LLKQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDL--------EEHQGEMNQKYK 359
Query: 83 ELKKRCEELEAQLKV-KENENAELLKELEQKNAMITVLE------NTIKEREKKYLEELK 135
ELKKR E ++ ++ +E +N EL ++ + + ++ +LE N I++ +ELK
Sbjct: 360 ELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELK 419
Query: 136 AKSHKLTLLSSELEQRASTIAYLTS-----QLHAAKKKLMSSSGTSD 177
L S+E+++ ST LTS QL K +L+ S T +
Sbjct: 420 MMQDDLNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEE 466
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/150 (24%), Positives = 71/150 (47%), Gaps = 25/150 (16%)
Query: 53 RRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCE-------ELEAQLKVKENENAEL 105
R LQ L ++ K+ + + +K++EL+K+ + EL+ ++K E++ +
Sbjct: 446 RHLQIEIEGLIDQMIDKTKVEKSE--AKAAELEKKLDSELTARHELQVEMKKMESDFEQK 503
Query: 106 LKELE-QKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHA 164
L++L+ +K+A+ + + E++ L +E+ Q +A LT +L
Sbjct: 504 LQDLQGEKDALHSEKQQIATEKQD---------------LEAEVSQLTGEVAKLTKELED 548
Query: 165 AKKKLMSSSGTSDASPSGSPVLASYKPAPP 194
AKK++ S S + P P A PAPP
Sbjct: 549 AKKEMASLSAAAITVPPSVPSRAPVPPAPP 578
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 44.3 bits (103), Expect = 2e-04
Identities = 37/150 (24%), Positives = 71/150 (47%), Gaps = 25/150 (16%)
Query: 53 RRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCE-------ELEAQLKVKENENAEL 105
R LQ L ++ K+ + + +K++EL+K+ + EL+ ++K E++ +
Sbjct: 455 RHLQIEIEGLIDQMIDKTKVEKSE--AKAAELEKKLDSELTARHELQVEMKKMESDFEQK 512
Query: 106 LKELE-QKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHA 164
L++L+ +K+A+ + + E++ L +E+ Q +A LT +L
Sbjct: 513 LQDLQGEKDALHSEKQQIATEKQD---------------LEAEVSQLTGEVAKLTKELED 557
Query: 165 AKKKLMSSSGTSDASPSGSPVLASYKPAPP 194
AKK++ S S + P P A PAPP
Sbjct: 558 AKKEMASLSAAAITVPPSVPSRAPVPPAPP 587
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 43.9 bits (102), Expect = 2e-04
Identities = 38/151 (25%), Positives = 71/151 (47%), Gaps = 13/151 (8%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
L+ QL AQ+ L R+H L L E L Q DL ++ S+ S
Sbjct: 969 LQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS--- 1025
Query: 83 ELKKRCEELEAQLKVKE-NENAELLKELEQKNAMITVLENTIKEREKKYL---EELKAKS 138
+R E E Q K++E E + KELE++ A +T+ ++ E+E++ L E +
Sbjct: 1026 ---QRLVEQEVQEKLRETQEYNRIQKELEREKASLTL---SLMEKEQRLLVLQEADSIRQ 1079
Query: 139 HKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+L+ L ++++ L++Q+ ++++
Sbjct: 1080 QELSALRQDMQEAQGEQKELSAQMELLRQEV 1110
Score = 36.2 bits (82), Expect = 0.042
Identities = 41/177 (23%), Positives = 76/177 (42%), Gaps = 17/177 (9%)
Query: 24 ENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE 83
+ ++ A LL L + + L E + + C + L + E+ T + +
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 84 LKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLE------ELKAK 137
+++ ++ E Q V E++ L ELE+K+ MI +++ +K+ + EL+
Sbjct: 1510 IRELEKDRETQRNVLEHQ----LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEEN 1565
Query: 138 SHKLTL---LSSELEQRAST----IAYLTSQLHAAKKKLMSSSGTSDASPSGSPVLA 187
HK+ L ELE + T + +LT L ++L + S S S VLA
Sbjct: 1566 HHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 43.1 bits (100), Expect = 3e-04
Identities = 43/170 (25%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 7 SSYDEGPLDVSMAATNLENQLH-------SAQKNLLFLQREHASTLKGLHSEIRRLQQHC 59
++ E +VS LE +L A + + +QR T+ LH + +
Sbjct: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846
Query: 60 TDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVL 119
+DL K E D +K E +R E+L + EN+ AE++K ++ +T +
Sbjct: 847 SDLE-----KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 901
Query: 120 ENTIKEREKKYLEELKAKSHKLTLLSSELEQRAS--TIAYLTSQLHAAKK 167
+ ++ +E+ +EEL+ K K +S L++ T+ SQ AAKK
Sbjct: 902 NDELRLKERD-VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
Score = 42.7 bits (99), Expect = 4e-04
Identities = 40/193 (20%), Positives = 78/193 (40%), Gaps = 29/193 (15%)
Query: 19 AATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGT 78
A L + S + L +E++ + S++ EL V S+ G T
Sbjct: 548 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 607
Query: 79 SKSSELKKRCEELE-------------------AQLKVKENENAELLKELEQKNAMITVL 119
++ +ELK + E++ A K E A+L+K +++K + +
Sbjct: 608 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 667
Query: 120 ENTIKEREKKYL----------EELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+ + + E ++L +E + K +L +L ++ ++ I TSQL A ++KL
Sbjct: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL 727
Query: 170 MSSSGTSDASPSG 182
+ AS G
Sbjct: 728 LDLDALRKASSEG 740
Score = 40.0 bits (92), Expect = 0.003
Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 15/156 (9%)
Query: 17 SMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGD 76
S T E L + QK LL + LKG E L Q +L + + QT +
Sbjct: 988 SETKTKHEEILQNLQKTLL----DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE 1043
Query: 77 GTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKA 136
+ E Q+ ++ E L++ +Q NA + +T+KE K +EEL
Sbjct: 1044 DAMQIME----------QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1093
Query: 137 KSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSS 172
LT+ + ++E+ I L Q A K + +S+
Sbjct: 1094 SKELLTVENQKMEEFRKEIETL-KQAAAQKSQQLSA 1128
Score = 34.3 bits (77), Expect = 0.16
Identities = 38/159 (23%), Positives = 67/159 (42%), Gaps = 10/159 (6%)
Query: 24 ENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE 83
EN L + + L + +H ++ ++++ + +L L K +EQT + +S+
Sbjct: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNFTSQ 719
Query: 84 LKKRCE---ELEAQLKVKENENAELLK---ELEQKNAMITVLE---NTIKEREKKYLEEL 134
LK E +L+A K +E+ K +LE I LE N + EL
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 779
Query: 135 KAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSS 173
+ + KLT L L + + L +L K+K +S
Sbjct: 780 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818
Score = 33.5 bits (75), Expect = 0.27
Identities = 36/160 (22%), Positives = 65/160 (40%), Gaps = 9/160 (5%)
Query: 15 DVSMAATNLENQLHSAQKNLLFLQREHASTLKGLH---SEIRRLQQHCTDLTYELTVKSS 71
+ S ++E+ A+++ ++H K L S++ + + + EL +
Sbjct: 925 NASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 984
Query: 72 EQTGDGTSKSSE----LKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKERE 127
T + +K E L+K + E +LK EN+ LL+ELE+ + +
Sbjct: 985 RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1044
Query: 128 KKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKK 167
+ E K TL S LE T A L ++L K+
Sbjct: 1045 AMQIMEQMTKEKTETLAS--LEDTKQTNAKLQNELDTLKE 1082
Score = 32.3 bits (72), Expect = 0.60
Identities = 27/121 (22%), Positives = 56/121 (46%), Gaps = 9/121 (7%)
Query: 50 SEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS-ELKKRCEELEAQLKVKENENAELLKE 108
+E+ + H ++ EL + DG + EL+ + ++L ++ + E ELL +
Sbjct: 376 AEVAKATSHVGEIEQELALAR-----DGHDQHVLELEAKMDQLRTMVEAADREKVELLNQ 430
Query: 109 LEQKNAMITVLENTIKERE--KKYLE-ELKAKSHKLTLLSSELEQRASTIAYLTSQLHAA 165
LE++ + L+ ++E K LE ++ ++ L +L R +A L +L +
Sbjct: 431 LEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 490
Query: 166 K 166
K
Sbjct: 491 K 491
Score = 31.6 bits (70), Expect = 1.0
Identities = 44/178 (24%), Positives = 71/178 (39%), Gaps = 32/178 (17%)
Query: 20 ATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTS 79
A + Q+ + L + T L +E+ L+++ EL KS E
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN-KSKELLTVENQ 1103
Query: 80 KSSELKKRCEELEA-------QLKVKENENAELLKELEQKNAMIT----------VLENT 122
K E +K E L+ QL + EN +L +EL + +T VL N
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1163
Query: 123 I---KEREKKYL---EELKAKSHK--------LTLLSSELEQRASTIAYLTSQLHAAK 166
+ K+RE K++ +E KA K LT +ELE+ + + L + +AK
Sbjct: 1164 LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAK 1221
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 43.1 bits (100), Expect = 3e-04
Identities = 43/170 (25%), Positives = 76/170 (44%), Gaps = 15/170 (8%)
Query: 7 SSYDEGPLDVSMAATNLENQLH-------SAQKNLLFLQREHASTLKGLHSEIRRLQQHC 59
++ E +VS LE +L A + + +QR T+ LH + +
Sbjct: 822 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 881
Query: 60 TDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVL 119
+DL K E D +K E +R E+L + EN+ AE++K ++ +T +
Sbjct: 882 SDLE-----KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 936
Query: 120 ENTIKEREKKYLEELKAKSHKLTLLSSELEQRAS--TIAYLTSQLHAAKK 167
+ ++ +E+ +EEL+ K K +S L++ T+ SQ AAKK
Sbjct: 937 NDELRLKERD-VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 985
Score = 42.7 bits (99), Expect = 4e-04
Identities = 40/193 (20%), Positives = 78/193 (40%), Gaps = 29/193 (15%)
Query: 19 AATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGT 78
A L + S + L +E++ + S++ EL V S+ G T
Sbjct: 583 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 642
Query: 79 SKSSELKKRCEELE-------------------AQLKVKENENAELLKELEQKNAMITVL 119
++ +ELK + E++ A K E A+L+K +++K + +
Sbjct: 643 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 702
Query: 120 ENTIKEREKKYL----------EELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+ + + E ++L +E + K +L +L ++ ++ I TSQL A ++KL
Sbjct: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL 762
Query: 170 MSSSGTSDASPSG 182
+ AS G
Sbjct: 763 LDLDALRKASSEG 775
Score = 40.0 bits (92), Expect = 0.003
Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 15/156 (9%)
Query: 17 SMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGD 76
S T E L + QK LL + LKG E L Q +L + + QT +
Sbjct: 1023 SETKTKHEEILQNLQKTLL----DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE 1078
Query: 77 GTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKA 136
+ E Q+ ++ E L++ +Q NA + +T+KE K +EEL
Sbjct: 1079 DAMQIME----------QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1128
Query: 137 KSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSS 172
LT+ + ++E+ I L Q A K + +S+
Sbjct: 1129 SKELLTVENQKMEEFRKEIETL-KQAAAQKSQQLSA 1163
Score = 34.3 bits (77), Expect = 0.16
Identities = 38/159 (23%), Positives = 67/159 (42%), Gaps = 10/159 (6%)
Query: 24 ENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE 83
EN L + + L + +H ++ ++++ + +L L K +EQT + +S+
Sbjct: 696 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNFTSQ 754
Query: 84 LKKRCE---ELEAQLKVKENENAELLK---ELEQKNAMITVLE---NTIKEREKKYLEEL 134
LK E +L+A K +E+ K +LE I LE N + EL
Sbjct: 755 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 814
Query: 135 KAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSS 173
+ + KLT L L + + L +L K+K +S
Sbjct: 815 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
Score = 33.5 bits (75), Expect = 0.27
Identities = 36/160 (22%), Positives = 65/160 (40%), Gaps = 9/160 (5%)
Query: 15 DVSMAATNLENQLHSAQKNLLFLQREHASTLKGLH---SEIRRLQQHCTDLTYELTVKSS 71
+ S ++E+ A+++ ++H K L S++ + + + EL +
Sbjct: 960 NASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 1019
Query: 72 EQTGDGTSKSSE----LKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKERE 127
T + +K E L+K + E +LK EN+ LL+ELE+ + +
Sbjct: 1020 RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1079
Query: 128 KKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKK 167
+ E K TL S LE T A L ++L K+
Sbjct: 1080 AMQIMEQMTKEKTETLAS--LEDTKQTNAKLQNELDTLKE 1117
Score = 31.6 bits (70), Expect = 1.0
Identities = 44/178 (24%), Positives = 71/178 (39%), Gaps = 32/178 (17%)
Query: 20 ATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTS 79
A + Q+ + L + T L +E+ L+++ EL KS E
Sbjct: 1080 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN-KSKELLTVENQ 1138
Query: 80 KSSELKKRCEELEA-------QLKVKENENAELLKELEQKNAMIT----------VLENT 122
K E +K E L+ QL + EN +L +EL + +T VL N
Sbjct: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQ 1198
Query: 123 I---KEREKKYL---EELKAKSHK--------LTLLSSELEQRASTIAYLTSQLHAAK 166
+ K+RE K++ +E KA K LT +ELE+ + + L + +AK
Sbjct: 1199 LLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAK 1256
Score = 30.4 bits (67), Expect = 2.3
Identities = 49/190 (25%), Positives = 70/190 (36%), Gaps = 25/190 (13%)
Query: 23 LENQLHSAQKNLLFLQR--EHASTLKG--------LHSEIRRLQQHCTDLTYELTV--KS 70
L NQL ++ + LQ E S KG H+ I+ L+Q L +E T K
Sbjct: 427 LLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQ---SLLFEKTKADKL 483
Query: 71 SEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNA-----MITVLENTIKE 125
+ D + K R ELE L ++ E AEL + LE M L I
Sbjct: 484 QRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 543
Query: 126 REKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMS-----SSGTSDASP 180
++K ++T L R T L+ A +KL S A+
Sbjct: 544 LQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK 603
Query: 181 SGSPVLASYK 190
S V+A +K
Sbjct: 604 ENSDVIALWK 613
Score = 29.6 bits (65), Expect = 3.9
Identities = 27/128 (21%), Positives = 54/128 (42%), Gaps = 11/128 (8%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLK 107
L ++ QQH L E ++ +E ++ E+E +L + + + + +
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEV--------AKATSHVGEIEQELALARDGHDQHVL 404
Query: 108 ELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQL---HA 164
ELE K + + + + L +L+ + K+ L +E+ + T L +Q HA
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 165 AKKKLMSS 172
K+L S
Sbjct: 465 RIKELEQS 472
>gi|187761317 tet oncogene family member 2 isoform a [Homo sapiens]
Length = 2002
Score = 42.7 bits (99), Expect = 4e-04
Identities = 42/161 (26%), Positives = 69/161 (42%), Gaps = 20/161 (12%)
Query: 91 LEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSS---- 146
+EAQ + K + ++L +K M+ T ++R+ LE KA + KL+ L +
Sbjct: 1432 VEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRQRK---LEAKKAAAEKLSSLENSSNK 1488
Query: 147 -ELEQRASTIAYLTSQLHAAKK--KLMSSSGTSDASPSGSPVLASYKPAPPKDKLPETPR 203
E E+ A + T AK+ +L+ SG PV+ + P K P P+
Sbjct: 1489 NEKEKSAPSRTKQTENASQAKQLAELLRLSG---------PVMQQSQQPQPLQKQPPQPQ 1539
Query: 204 RRMKKSLSAPLHPEFEEVYRFGAE-SRKLLLREPVDAMPDP 243
++ + P HP+ E V + A S +R P P P
Sbjct: 1540 QQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYP 1580
>gi|27894337 keratin 20 [Homo sapiens]
Length = 424
Score = 42.7 bits (99), Expect = 4e-04
Identities = 40/173 (23%), Positives = 74/173 (42%), Gaps = 24/173 (13%)
Query: 15 DVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTD----LTYELTVKS 70
D+++ T+LE Q+ K+L L++EH + GLH + D L + +
Sbjct: 182 DLTLHKTDLEIQIEELNKDLALLKKEHQEEVDGLHKHLGNTVNVEVDAAPGLNLGVIMNE 241
Query: 71 SEQTGDGTSKSS--ELKKRCEELEAQLKVKENENAELLK------------------ELE 110
Q + ++ + E K++ E A L+ + N E LK EL+
Sbjct: 242 MRQKYEVMAQKNLQEAKEQFERQTAVLQQQVTVNTEELKGTEVQLTELRRTSQSLEIELQ 301
Query: 111 QKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLH 163
+M LE+T++E + +Y +L L+ L ++L Q S + ++ H
Sbjct: 302 SHLSMKESLEHTLEETKARYSSQLANLQSLLSSLEAQLMQIRSNMERQNNEYH 354
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 42.7 bits (99), Expect = 4e-04
Identities = 37/169 (21%), Positives = 78/169 (46%), Gaps = 16/169 (9%)
Query: 6 FSSYDEGPLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYE 65
F+ +E ++ LE LH + + E + L +E +++Q H DL +
Sbjct: 903 FAEAEEMRARLAAKKQELEEILHDLESRV----EEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 66 LTVKSSEQTGDGTSKSSELKK-----RCEELEAQLKVKENENAELLKELEQKNAMITVLE 120
L + +G + +L+K + +++E ++ + E++N++ +KE + I
Sbjct: 959 LDEE------EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 121 NTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+ + E E+K + L +K ++ S+LE+R +L AK+KL
Sbjct: 1013 SQLAEEEEK-AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Score = 35.4 bits (80), Expect = 0.071
Identities = 74/291 (25%), Positives = 112/291 (38%), Gaps = 63/291 (21%)
Query: 24 ENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE 83
E +L S + +L LQ E AS+ + R +Q +L E+T +S ++ K
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERAR----RHAEQERDELADEITNSASGKSALLDEKR-R 1733
Query: 84 LKKRCEELEAQLKVKENENAELL--------------------------------KELEQ 111
L+ R +LE +L+ +E N ELL ++LE+
Sbjct: 1734 LEARIAQLEEELE-EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER 1792
Query: 112 KN----AMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKK 167
+N A + LE +K + K + L+AK + L +LEQ A A + +K
Sbjct: 1793 QNKELKAKLQELEGAVKSKFKATISALEAK---IGQLEEQLEQEAKERAAANKLVRRTEK 1849
Query: 168 KLMSSSGTSDASPSGSPVLASYKPAPPKDKLPETPRRRMKKSLSAPLHPEFEEVYRFGAE 227
KL V + A + E RMK+ L L EE R A
Sbjct: 1850 KLKEIF---------MQVEDERRHADQYKEQMEKANARMKQ-LKRQLEEAEEEATRANAS 1899
Query: 228 SRKLLLREPVDAMPDPTPFLLARESAEVHLIKERPLVIPPI--ASDRSGEQ 276
RK L+ +D + L S EV +K R PI +S RSG +
Sbjct: 1900 RRK--LQRELDDATEANEGL----SREVSTLKNRLRRGGPISFSSSRSGRR 1944
Score = 30.8 bits (68), Expect = 1.7
Identities = 29/115 (25%), Positives = 51/115 (44%), Gaps = 10/115 (8%)
Query: 18 MAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDG 77
+ T E +L + + LL + +E + ++G E+ R Q + L + +T
Sbjct: 845 LQVTRQEEELQAKDEELLKV-KEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET--- 900
Query: 78 TSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLE 132
EL EE+ A+L K+ E E+L +LE + N I + EKK ++
Sbjct: 901 -----ELFAEAEEMRARLAAKKQELEEILHDLESR-VEEEEERNQILQNEKKKMQ 949
Score = 30.4 bits (67), Expect = 2.3
Identities = 36/155 (23%), Positives = 62/155 (40%), Gaps = 15/155 (9%)
Query: 28 HSAQKNLLFLQREHASTLKGLHSEI---RRLQQHCTDLTYELTVKSSE--QTGDGTSKSS 82
++A K + LQ + A + SE + ++ DL+ EL +E T D T+
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 83 ELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLT 142
EL+ + +E E AEL K LE++ +++R LEEL + +
Sbjct: 1167 ELRTK----------REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 143 LLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSD 177
+ LE+ + +L K L S+
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Score = 28.9 bits (63), Expect = 6.6
Identities = 36/199 (18%), Positives = 82/199 (41%), Gaps = 19/199 (9%)
Query: 22 NLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKS 81
N++ +++L ++ + L ++R L+ D +Q +
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED--------ERKQRALAVASK 1619
Query: 82 SELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKL 141
+++ ++LEAQ++ E++K+L + L+ +K+ +++ LEE +A ++
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRK-------LQAQMKDYQRE-LEEARASRDEI 1671
Query: 142 TLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASPSGSPVLASYKPAPPKDKLPET 201
S E E++ + L +++ +++L SS + LA K
Sbjct: 1672 FAQSKESEKKLKS---LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728
Query: 202 PRRRMKKSLSAPLHPEFEE 220
+R ++ A L E EE
Sbjct: 1729 DEKRRLEARIAQLEEELEE 1747
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 42.7 bits (99), Expect = 4e-04
Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 18/109 (16%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLK 107
L ++I L++ C+++ E K+++LK+R EELEA+L+ KE E +L K
Sbjct: 225 LRNKIDELEEQCSEINRE------------KEKNTQLKRRIEELEAELREKETELKDLRK 272
Query: 108 ELEQKNAMITVLENTIK-----EREKKYLEELKAKSHKLTLLSSELEQR 151
+ E +++ E + ER+ + LE+ K +S K + S+ QR
Sbjct: 273 QSEIIPQLMSECEYVSEKLEAAERDNQNLED-KVRSLKTDIEESKYRQR 320
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 42.7 bits (99), Expect = 4e-04
Identities = 32/109 (29%), Positives = 57/109 (52%), Gaps = 18/109 (16%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLK 107
L ++I L++ C+++ E K+++LK+R EELEA+L+ KE E +L K
Sbjct: 214 LRNKIDELEEQCSEINRE------------KEKNTQLKRRIEELEAELREKETELKDLRK 261
Query: 108 ELEQKNAMITVLENTIK-----EREKKYLEELKAKSHKLTLLSSELEQR 151
+ E +++ E + ER+ + LE+ K +S K + S+ QR
Sbjct: 262 QSEIIPQLMSECEYVSEKLEAAERDNQNLED-KVRSLKTDIEESKYRQR 309
>gi|214010216 SMC6 protein [Homo sapiens]
Length = 1091
Score = 42.7 bits (99), Expect = 4e-04
Identities = 42/160 (26%), Positives = 68/160 (42%), Gaps = 29/160 (18%)
Query: 36 FLQREHASTLKGLHSEIRR-------LQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRC 88
FL R+ S + L +E+ LQQH + L E +K +E EL KRC
Sbjct: 659 FLSRDVDSEISDLENEVENKTAQILNLQQHLSAL--EKDIKHNE----------ELLKRC 706
Query: 89 EELEAQLKVKENENAELLKEL----EQKNAMITVLENTIKEREKK------YLEELKAKS 138
+ +LK+K +N ++EL E ++ I LE+ +E + K ++E+ K
Sbjct: 707 QLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENM 766
Query: 139 HKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDA 178
L L E E + I + +QL L +D+
Sbjct: 767 EHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADS 806
Score = 31.2 bits (69), Expect = 1.3
Identities = 24/118 (20%), Positives = 51/118 (43%), Gaps = 2/118 (1%)
Query: 36 FLQREHASTLKGLHSEIRRLQQHCTDLTYELTVK--SSEQTGDGTSKSSELKKRCEELEA 93
FLQ ++ + +L+Q D +Y + K + EQ G + +ELK++C E E
Sbjct: 197 FLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEE 256
Query: 94 QLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQR 151
+ + + K+ M + N I+++ + +K + L ++E++
Sbjct: 257 RFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQ 314
>gi|13375848 SMC6 protein [Homo sapiens]
Length = 1091
Score = 42.7 bits (99), Expect = 4e-04
Identities = 42/160 (26%), Positives = 68/160 (42%), Gaps = 29/160 (18%)
Query: 36 FLQREHASTLKGLHSEIRR-------LQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRC 88
FL R+ S + L +E+ LQQH + L E +K +E EL KRC
Sbjct: 659 FLSRDVDSEISDLENEVENKTAQILNLQQHLSAL--EKDIKHNE----------ELLKRC 706
Query: 89 EELEAQLKVKENENAELLKEL----EQKNAMITVLENTIKEREKK------YLEELKAKS 138
+ +LK+K +N ++EL E ++ I LE+ +E + K ++E+ K
Sbjct: 707 QLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENM 766
Query: 139 HKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDA 178
L L E E + I + +QL L +D+
Sbjct: 767 EHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADS 806
Score = 31.2 bits (69), Expect = 1.3
Identities = 24/118 (20%), Positives = 51/118 (43%), Gaps = 2/118 (1%)
Query: 36 FLQREHASTLKGLHSEIRRLQQHCTDLTYELTVK--SSEQTGDGTSKSSELKKRCEELEA 93
FLQ ++ + +L+Q D +Y + K + EQ G + +ELK++C E E
Sbjct: 197 FLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEE 256
Query: 94 QLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQR 151
+ + + K+ M + N I+++ + +K + L ++E++
Sbjct: 257 RFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQ 314
>gi|46409266 coiled-coil domain containing 74B [Homo sapiens]
Length = 380
Score = 42.7 bits (99), Expect = 4e-04
Identities = 20/49 (40%), Positives = 30/49 (61%)
Query: 31 QKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTS 79
+K+L FLQ++H+ L LH EI L++ DL Y+L + + Q DG S
Sbjct: 54 EKSLQFLQQQHSEMLAKLHEEIEHLKRENKDLRYKLIMNQTSQKKDGPS 102
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 42.4 bits (98), Expect = 6e-04
Identities = 29/100 (29%), Positives = 56/100 (56%), Gaps = 5/100 (5%)
Query: 84 LKKRCEELEAQLKVKENENAELLKELEQKNAMITVL----ENTIKEREKKYLEELKAKSH 139
LK L+ Q +VKEN+ E +K L++KNA + + + T+ +R +Y E+LK +
Sbjct: 1094 LKLEVATLKHQHQVKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRASQYREQLKVLTA 1153
Query: 140 KLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDAS 179
+ T+L+S+L+++ L +++ + +L S+ D S
Sbjct: 1154 ENTMLTSKLKEKQDK-EILETEIESHHPRLASALQDHDQS 1192
Score = 32.7 bits (73), Expect = 0.46
Identities = 19/74 (25%), Positives = 33/74 (44%)
Query: 100 NENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLT 159
+EN L KE+ + L++ + +E KY E++K K L L+ + T+
Sbjct: 1082 HENCMLKKEIAMLKLEVATLKHQHQVKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRA 1141
Query: 160 SQLHAAKKKLMSSS 173
SQ K L + +
Sbjct: 1142 SQYREQLKVLTAEN 1155
Score = 30.8 bits (68), Expect = 1.7
Identities = 24/73 (32%), Positives = 42/73 (57%), Gaps = 7/73 (9%)
Query: 80 KSSELKK-RCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKS 138
+ ELKK CE++ A+++ +N+ L KEL + + + LEN ++ K+ +EL S
Sbjct: 958 RGRELKKDNCEQITAKMEQTKNKFCVLQKELSEAKEIKSQLEN----QKAKWEQEL--CS 1011
Query: 139 HKLTLLSSELEQR 151
+LTL E ++R
Sbjct: 1012 VRLTLNQEEEKRR 1024
Score = 30.4 bits (67), Expect = 2.3
Identities = 28/124 (22%), Positives = 55/124 (44%), Gaps = 25/124 (20%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS 82
L+ ++ + + L+ +H +I+ LQ+ +L ++T+K ++T
Sbjct: 1087 LKKEIAMLKLEVATLKHQHQVKENKYFEDIKILQEKNAEL--QMTLKLKQKT-------- 1136
Query: 83 ELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLT 142
+ KR + QLKV EN T+L + +KE++ K + E + +SH
Sbjct: 1137 -VTKRASQYREQLKVLTAEN--------------TMLTSKLKEKQDKEILETEIESHHPR 1181
Query: 143 LLSS 146
L S+
Sbjct: 1182 LASA 1185
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 42.4 bits (98), Expect = 6e-04
Identities = 50/219 (22%), Positives = 88/219 (40%), Gaps = 40/219 (18%)
Query: 20 ATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDL-TYELTVKS-------- 70
AT L+ QL S + + L+ E A T L + ++ +H +L + L VK
Sbjct: 3147 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3206
Query: 71 SEQTGDGTSKSSEL------------------KKRCEELEAQLKVKENENAELLKELEQK 112
++ KS EL K+ E+L+ L+ ++ N +L LEQ+
Sbjct: 3207 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3266
Query: 113 NAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKK---KL 169
++ + I+ + Y +L + + L LE I ++S L ++ +L
Sbjct: 3267 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3326
Query: 170 MSSSGTSDASPSGSPVLASYKPAPPKDKLPETPRRRMKK 208
SS GT + P P P +D L E ++ +K
Sbjct: 3327 QSSDGTGQSRP----------PLPSEDLLKELQKQLEEK 3355
Score = 38.1 bits (87), Expect = 0.011
Identities = 31/115 (26%), Positives = 58/115 (50%), Gaps = 14/115 (12%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS--ELKKRCEELEAQLKVKENENAEL 105
++S+ + +L E+ + E+ GT + EL+ + E LE Q+K KEN+ E
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
Query: 106 LKELEQKNAMIT----VLENTIK-------EREKKYLEELKAKSHKLTLLSSELE 149
+LE +N+++ LE+ +K E +L+ +K+KS K ++ E+E
Sbjct: 770 FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKS-KDSVWEKEIE 823
Score = 35.0 bits (79), Expect = 0.093
Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 3/114 (2%)
Query: 37 LQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLK 96
LQ E + ++ + E L L E++ Q SKS E+ + EL+ +++
Sbjct: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 97 V---KENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSE 147
+ +E E L +E+++ +LE +KE+E E+ + ++L E
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Score = 33.9 bits (76), Expect = 0.21
Identities = 35/114 (30%), Positives = 48/114 (42%), Gaps = 10/114 (8%)
Query: 62 LTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLEN 121
L Y + K S+ SS +K R EL+ QL ++ AEL EL Q LE
Sbjct: 3122 LEYNIQQKQSQMLEMQVELSS-MKDRATELQEQLSSEKMVVAELKSELAQTK---LELET 3177
Query: 122 TIKEREKKYLE------ELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
T+K + K E E+K K+ ++ LL+ L L L K KL
Sbjct: 3178 TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3231
Score = 32.3 bits (72), Expect = 0.60
Identities = 27/125 (21%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE---LKKRCEELEAQLKVKENENAE 104
L SE R+++ + L E + + Q+ DGT +S + +EL+ QL+ K + E
Sbjct: 3302 LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVE 3361
Query: 105 LLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHA 164
LL E E+ +++ + + + L+ + T ++ + S + L QL
Sbjct: 3362 LLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3421
Query: 165 AKKKL 169
++++
Sbjct: 3422 KRQQV 3426
Score = 30.4 bits (67), Expect = 2.3
Identities = 30/123 (24%), Positives = 47/123 (38%), Gaps = 14/123 (11%)
Query: 80 KSSELKKRCEELEAQLKVKE----NENAELLKELEQKNAMITVLENTI---KEREKKYLE 132
+ E K+ +++E E NE + ELE A + + KE+ +K E
Sbjct: 2658 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2717
Query: 133 ELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASPSGSPVLASYKPA 192
EL K +T L +L Q + L AK+KL + S ++P
Sbjct: 2718 ELLVKETNMTSLQKDLSQ-------VRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2770
Query: 193 PPK 195
P K
Sbjct: 2771 PIK 2773
Score = 29.6 bits (65), Expect = 3.9
Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 5/119 (4%)
Query: 13 PLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSE 72
PL L+ QL ++ L E T K ++ QQ D +E
Sbjct: 3338 PLPSEDLLKELQKQLEEKHSRIVELLNE---TEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3394
Query: 73 QTG--DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKK 129
Q +G K EL+ + E+L+ QL+ K + +L E ++ ++ + ERE+K
Sbjct: 3395 QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3453
Score = 29.3 bits (64), Expect = 5.1
Identities = 28/118 (23%), Positives = 55/118 (46%), Gaps = 7/118 (5%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRL---QQHCTDLTYELTVKSSE-QTGDGT 78
+ ++ S K + Q H R+L ++ D+ EL + E Q
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
Query: 79 SKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKA 136
+ + +++ + E Q +++E E L ++L Q++++ EN + ERE+ LEEL+A
Sbjct: 1608 LRQAHMRQMERQREDQEQLQE-EIKRLNRQLAQRSSIDN--ENLVSERERVLLEELEA 1662
Score = 29.3 bits (64), Expect = 5.1
Identities = 19/84 (22%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 83 ELKKRCEELEAQLKVKEN-----ENAELLKELEQKNAMITVLENTIKEREKKYLEELKAK 137
+L ++ +L+ QLK+ + E EL+++LE + + + +K ++ +E+L
Sbjct: 2296 QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV 2355
Query: 138 SHKLTLLSSELEQRASTIAYLTSQ 161
KL + + Q+ S A+ S+
Sbjct: 2356 IEKLQQELANIGQKTSMNAHSLSE 2379
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 42.4 bits (98), Expect = 6e-04
Identities = 50/219 (22%), Positives = 88/219 (40%), Gaps = 40/219 (18%)
Query: 20 ATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDL-TYELTVKS-------- 70
AT L+ QL S + + L+ E A T L + ++ +H +L + L VK
Sbjct: 3139 ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198
Query: 71 SEQTGDGTSKSSEL------------------KKRCEELEAQLKVKENENAELLKELEQK 112
++ KS EL K+ E+L+ L+ ++ N +L LEQ+
Sbjct: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258
Query: 113 NAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKK---KL 169
++ + I+ + Y +L + + L LE I ++S L ++ +L
Sbjct: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3318
Query: 170 MSSSGTSDASPSGSPVLASYKPAPPKDKLPETPRRRMKK 208
SS GT + P P P +D L E ++ +K
Sbjct: 3319 QSSDGTGQSRP----------PLPSEDLLKELQKQLEEK 3347
Score = 38.1 bits (87), Expect = 0.011
Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 10/89 (11%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSS--ELKKRCEELEAQLKVKENENAEL 105
++S+ + +L E+ + E+ GT + EL+ + E LE Q+K KEN+ E
Sbjct: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769
Query: 106 LKELEQKNAMITVLENTIKEREKKYLEEL 134
+LE EN+I + EKK LE++
Sbjct: 770 FAQLE--------AENSILKDEKKTLEDM 790
Score = 35.0 bits (79), Expect = 0.093
Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 3/114 (2%)
Query: 37 LQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLK 96
LQ E + ++ + E L L E++ Q SKS E+ + EL+ +++
Sbjct: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 97 V---KENENAELLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSE 147
+ +E E L +E+++ +LE +KE+E E+ + ++L E
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783
Score = 33.9 bits (76), Expect = 0.21
Identities = 35/114 (30%), Positives = 48/114 (42%), Gaps = 10/114 (8%)
Query: 62 LTYELTVKSSEQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLEN 121
L Y + K S+ SS +K R EL+ QL ++ AEL EL Q LE
Sbjct: 3114 LEYNIQQKQSQMLEMQVELSS-MKDRATELQEQLSSEKMVVAELKSELAQTK---LELET 3169
Query: 122 TIKEREKKYLE------ELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
T+K + K E E+K K+ ++ LL+ L L L K KL
Sbjct: 3170 TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3223
Score = 32.3 bits (72), Expect = 0.60
Identities = 38/170 (22%), Positives = 76/170 (44%), Gaps = 21/170 (12%)
Query: 14 LDVSMAATNLENQLHSAQKNL--LFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSS 71
+D+ LE QL +K L + REH + EI++L+Q + + S
Sbjct: 2049 MDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV--FQQEIQKLEQQLKVVPRFQPI-SE 2105
Query: 72 EQTGDGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKERE---- 127
QT + ++ LK++ ++ L KE +L ++++++N I LE ++E E
Sbjct: 2106 HQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 128 ---KKYLEELKAKSH-----KLTLLSSELEQRASTIAYLTSQLHAAKKKL 169
+K+ ++AK +L ++++ I L QL +++L
Sbjct: 2162 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211
Score = 32.3 bits (72), Expect = 0.60
Identities = 27/125 (21%), Positives = 57/125 (45%), Gaps = 3/125 (2%)
Query: 48 LHSEIRRLQQHCTDLTYELTVKSSEQTGDGTSKSSE---LKKRCEELEAQLKVKENENAE 104
L SE R+++ + L E + + Q+ DGT +S + +EL+ QL+ K + E
Sbjct: 3294 LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVE 3353
Query: 105 LLKELEQKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRASTIAYLTSQLHA 164
LL E E+ +++ + + + L+ + T ++ + S + L QL
Sbjct: 3354 LLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3413
Query: 165 AKKKL 169
++++
Sbjct: 3414 KRQQV 3418
Score = 30.4 bits (67), Expect = 2.3
Identities = 30/123 (24%), Positives = 47/123 (38%), Gaps = 14/123 (11%)
Query: 80 KSSELKKRCEELEAQLKVKE----NENAELLKELEQKNAMITVLENTI---KEREKKYLE 132
+ E K+ +++E E NE + ELE A + + KE+ +K E
Sbjct: 2650 REKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQE 2709
Query: 133 ELKAKSHKLTLLSSELEQRASTIAYLTSQLHAAKKKLMSSSGTSDASPSGSPVLASYKPA 192
EL K +T L +L Q + L AK+KL + S ++P
Sbjct: 2710 ELLVKETNMTSLQKDLSQ-------VRDHLAEAKEKLSILEKEDETEVQESKKACMFEPL 2762
Query: 193 PPK 195
P K
Sbjct: 2763 PIK 2765
Score = 30.0 bits (66), Expect = 3.0
Identities = 31/144 (21%), Positives = 62/144 (43%), Gaps = 9/144 (6%)
Query: 15 DVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSEQT 74
+V A +L+ + + LL + + ++ + EI +L+ +L L V+ +
Sbjct: 2110 EVEQLANHLKEKTDKCSE-LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHF 2168
Query: 75 GDGTSK---SSELKKRCEELEAQLKVKENENAE-----LLKELEQKNAMITVLENTIKER 126
G +K S E++ + E K KE N E +ELE KN + L ++ +
Sbjct: 2169 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2228
Query: 127 EKKYLEELKAKSHKLTLLSSELEQ 150
+K+ L+ + L ++E+
Sbjct: 2229 KKESTTRLQELEQENKLFKDDMEK 2252
Score = 29.6 bits (65), Expect = 3.9
Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 5/119 (4%)
Query: 13 PLDVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIRRLQQHCTDLTYELTVKSSE 72
PL L+ QL ++ L E T K ++ QQ D +E
Sbjct: 3330 PLPSEDLLKELQKQLEEKHSRIVELLNE---TEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3386
Query: 73 QTG--DGTSKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKK 129
Q +G K EL+ + E+L+ QL+ K + +L E ++ ++ + ERE+K
Sbjct: 3387 QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3445
Score = 29.3 bits (64), Expect = 5.1
Identities = 28/118 (23%), Positives = 55/118 (46%), Gaps = 7/118 (5%)
Query: 23 LENQLHSAQKNLLFLQREHASTLKGLHSEIRRL---QQHCTDLTYELTVKSSE-QTGDGT 78
+ ++ S K + Q H R+L ++ D+ EL + E Q
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
Query: 79 SKSSELKKRCEELEAQLKVKENENAELLKELEQKNAMITVLENTIKEREKKYLEELKA 136
+ + +++ + E Q +++E E L ++L Q++++ EN + ERE+ LEEL+A
Sbjct: 1608 LRQAHMRQMERQREDQEQLQE-EIKRLNRQLAQRSSIDN--ENLVSERERVLLEELEA 1662
Score = 29.3 bits (64), Expect = 5.1
Identities = 19/84 (22%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 83 ELKKRCEELEAQLKVKEN-----ENAELLKELEQKNAMITVLENTIKEREKKYLEELKAK 137
+L ++ +L+ QLK+ + E EL+++LE + + + +K ++ +E+L
Sbjct: 2288 QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV 2347
Query: 138 SHKLTLLSSELEQRASTIAYLTSQ 161
KL + + Q+ S A+ S+
Sbjct: 2348 IEKLQQELANIGQKTSMNAHSLSE 2371
>gi|131412228 keratin 13 isoform b [Homo sapiens]
Length = 420
Score = 42.4 bits (98), Expect = 6e-04
Identities = 36/163 (22%), Positives = 77/163 (47%), Gaps = 24/163 (14%)
Query: 15 DVSMAATNLENQLHSAQKNLLFLQREHASTLKGLHSEIR---RLQQHCT---DLT----- 63
+++++ T+LE Q+ S + L ++++ H +K +++ ++ T DLT
Sbjct: 217 ELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAE 276
Query: 64 ----YELTVKSSEQTGDGT--SKSSELKKRCEELEAQLKVKENENAELLK-------ELE 110
YE + + + + +KS+EL K A ++ + E EL + EL+
Sbjct: 277 MREQYEAMAERNRRDAEEWFHAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQ 336
Query: 111 QKNAMITVLENTIKEREKKYLEELKAKSHKLTLLSSELEQRAS 153
+ +M LENT+ E E +Y +L+ ++ + ++L + S
Sbjct: 337 SQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQLSELRS 379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,435,100
Number of Sequences: 37866
Number of extensions: 674262
Number of successful extensions: 5543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 606
Number of HSP's that attempted gapping in prelim test: 3909
Number of HSP's gapped (non-prelim): 2072
length of query: 331
length of database: 18,247,518
effective HSP length: 103
effective length of query: 228
effective length of database: 14,347,320
effective search space: 3271188960
effective search space used: 3271188960
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.