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Search of human proteins with 5174457
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174457 kinetochore associated 2 [Homo sapiens]
(642 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174457 kinetochore associated 2 [Homo sapiens] 1268 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 78 3e-14
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 78 3e-14
gi|38044112 restin isoform b [Homo sapiens] 76 1e-13
gi|4506751 restin isoform a [Homo sapiens] 76 1e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 75 1e-13
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 75 2e-13
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 74 3e-13
gi|71061468 centromere protein E [Homo sapiens] 74 4e-13
gi|156104908 myosin heavy chain 6 [Homo sapiens] 73 7e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 73 9e-13
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 73 9e-13
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 72 1e-12
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 72 2e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 71 3e-12
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 71 3e-12
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 71 3e-12
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 71 3e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 71 3e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 4e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 70 5e-12
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 70 6e-12
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 70 6e-12
gi|16262452 cingulin [Homo sapiens] 70 6e-12
gi|55770834 centromere protein F [Homo sapiens] 70 6e-12
gi|219555661 intraflagellar transport 81-like isoform 1 [Homo sa... 69 2e-11
gi|32526901 intraflagellar transport 81-like isoform 1 [Homo sap... 69 2e-11
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 69 2e-11
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 68 2e-11
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 68 2e-11
>gi|5174457 kinetochore associated 2 [Homo sapiens]
Length = 642
Score = 1268 bits (3280), Expect = 0.0
Identities = 642/642 (100%), Positives = 642/642 (100%)
Query: 1 MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKR 60
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKR
Sbjct: 1 MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKR 60
Query: 61 TSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAP 120
TSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAP
Sbjct: 61 TSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAP 120
Query: 121 SVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPH 180
SVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPH
Sbjct: 121 SVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPH 180
Query: 181 IVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGA 240
IVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGA
Sbjct: 181 IVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGA 240
Query: 241 DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK 300
DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK
Sbjct: 241 DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK 300
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK
Sbjct: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR
Sbjct: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM 480
KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM
Sbjct: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM 480
Query: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKH 540
GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKH
Sbjct: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKH 540
Query: 541 LLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHL 600
LLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHL
Sbjct: 541 LLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHL 600
Query: 601 EEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
EEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE
Sbjct: 601 EEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 77.8 bits (190), Expect = 3e-14
Identities = 87/386 (22%), Positives = 172/386 (44%), Gaps = 49/386 (12%)
Query: 248 AELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPN-RLESLRKLKASLQGD 306
A+L+ ++ L +++ LE +N LN+ ++ L Q + R++ + K L
Sbjct: 536 AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 307 VQKYQAYMSNLESHSAILDQKLNGLNEEIAR---VELECETIKQENTRLQNIIDNQKYSV 363
+++ + +S +E + ++L E+ R +E E +++EN LQ I N K +
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 364 ADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLK 423
IE + E +EL++ KL K L++ + L +L+
Sbjct: 656 EKIEALEQENSELERENRKLKKTLDS-------------------------FKNLTFQLE 690
Query: 424 LIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEE-----EINKALNK 478
+ K + E++ N E+ C AQ+ + KEL +E E+ E+ KA K
Sbjct: 691 SLEKENSQLDEENLELRRNVES-LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 479 K--------MGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCAS 530
K GL+ ++L + S + ++ L+ E+Q L ++ Q +++ EE + +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSK 808
Query: 531 ELESLEKHKHLLESTVNQGLSEAMNELDAVQ---REYQLVVQTTTEERRKVGNNLQRLLE 587
LE LEK LE +Q L + +L+ R+ + TT EE NL++ +
Sbjct: 809 RLEQLEKENKSLEQETSQ-LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 588 MVATHVGSVEKHLEEQIAKVDREYEE 613
++ +G + K ++ ++++E +E
Sbjct: 868 TLSKEIG-IYKESCVRLKELEKENKE 892
Score = 73.9 bits (180), Expect = 4e-13
Identities = 92/390 (23%), Positives = 173/390 (44%), Gaps = 40/390 (10%)
Query: 214 ETEDGIMHNKLF-LDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKN 272
E E+ ++ K+ L T + E+ + N +L+ L N+ F+LESLE +N
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL-TFQLESLEKEN 696
Query: 273 RALNEQ-----------------IARLEQEREKEPNRLESLRK----LKASLQGDVQKYQ 311
L+E+ +A+L+ E ++ + E L+K LKAS + ++ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLE 755
Query: 312 AYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINH 371
L+ + L + L N++I ++E E + ++ EN LQ ++ K S +E++
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815
Query: 372 ERNELQQTINKLTKD---LEAEQQKLWNE-ELKYARGKEAIETQLAEYHKLARKLKLIPK 427
E L+Q ++L KD LE E ++L + E+K +E + L ++ K + K
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK----DTTLEENNVKIGNLEKENKTLSK 871
Query: 428 GAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLE 487
K +K E LVK + + +K L+ E+ +++ L K + + LE
Sbjct: 872 EIGIYKESCVRLK-ELEKENKELVK---RATIDIKTLVTLREDLVSEKL-KTQQMNNDLE 926
Query: 488 QLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASEL--ESLEKHKHLLEST 545
+L + + + L + Q DD + ++ E K + E+ E + + LE +
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 986
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTEER 575
N + EL V++ Y+ + Q EER
Sbjct: 987 TNYN-QQLRQELKTVKKNYEALKQRQDEER 1015
Score = 63.9 bits (154), Expect = 4e-10
Identities = 93/411 (22%), Positives = 179/411 (43%), Gaps = 66/411 (16%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASL 303
++ N LQ K+ +L + K+E+LE +N + LE+E K L+S + L L
Sbjct: 638 EKENELLQKKITNL-KITCEKIEALEQEN-------SELERENRKLKKTLDSFKNLTFQL 689
Query: 304 QG-DVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYS 362
+ + + Q NLE + + L + ++A+++LE + ++ E +L+ ++ K S
Sbjct: 690 ESLEKENSQLDEENLELRRNV--ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Query: 363 VADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKL 422
ER+ L +L K LE +K+ E + + +E + K +L
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL----QDLEMENQTLQKNLEEL 803
Query: 423 KLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGL 482
K+ K E E L + +Q+ K+L E+ NK L ++ +
Sbjct: 804 KISSKRLEQL-----------EKENKSLEQETSQLEKDKKQL-----EKENKRLRQQAEI 847
Query: 483 EDT-LEQLNAMITESKRSVRTLKEEVQKLDDLYQQ---KIKEAEEEDEKCASELE-SLEK 537
+DT LE+ N I ++ +TL +E+ +Y++ ++KE E+E+++ ++
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 538 HKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLE---------- 587
L E V++ L D ++ T E K+G N +RLL
Sbjct: 904 LVTLREDLVSEKLKTQQMNND---------LEKLTHELEKIGLNKERLLHDEQSTDDSRY 954
Query: 588 --MVATHVGSVEKHL---EEQIAKVDREYEEC--MSEDLSENIKEIRDKYE 631
+ + +++K L EE+IA ++ EE ++ L + +K ++ YE
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1005
Score = 44.7 bits (104), Expect = 3e-04
Identities = 73/406 (17%), Positives = 179/406 (44%), Gaps = 43/406 (10%)
Query: 264 KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLES--HS 321
K+ L + EQ+ +QE E+ L+ L++ +L D + + Y L++
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 322 AI----LDQKLNGLNEEIARVEL---ECETIKQEN-------TRLQNIIDNQKYSVADIE 367
A+ L+ +++ E + +E E +K++N T L++ ++ + +
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 368 RINHERNELQQTINKLTKDLEAEQQKLW-----NEELKYARGKEAIETQLA---EYHKLA 419
+ E +L+ ++ + + + +++K+ N L+ A+ K++++ L E +++
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ-KQSMDESLHLGWELEQIS 437
Query: 420 RKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRA--QVYVPLKELLNETEEEINKALN 477
R +L + + S G++ E ++ L+K Q E L T + + +
Sbjct: 438 RTSEL-SEAPQKSLGHEVN-----ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 478 KKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEK 537
K + +E ++L+ + + + K+ +Q +L + +KE + ++ + E+ E+
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 538 HKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVE 597
+LE N+ L++ ++ L ++ Q+ + ++ K L ++ ++ + +E
Sbjct: 552 QIKILEQE-NEHLNQTVSSL---RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 598 KHLEEQIAKVDREYEEC--MSEDLSENIKEIRDKYE---KKATLIK 638
+ QI K Y+E +E+L + + + E KK T +K
Sbjct: 608 FE-KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
Score = 42.7 bits (99), Expect = 0.001
Identities = 81/353 (22%), Positives = 144/353 (40%), Gaps = 68/353 (19%)
Query: 266 ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
ES E L + +E ER +L+ K +L+ +++ + +NL++ L
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNA-----TLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 326 QKLNGLNEEIARVELECETIKQENTRLQN-----------IIDNQKYSVADIERINHERN 374
++ L E+ ++ + ++ EN+ L + ++ Q + E + ER
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147
Query: 375 ELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKG 434
+L+ + L KD +E+L+ E Q +EY L K G S
Sbjct: 1148 DLKSLYDSLIKD---------HEKLELLH-----ERQASEYESLISK-----HGTLKSAH 1188
Query: 435 YDFEIKFNP-EAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMI 493
+ E++ E N L+K + Q+ E E++ K +KM LE+ + A
Sbjct: 1189 KNLEVEHRDLEDRYNQLLKQKGQL---------EDLEKMLKVEQEKMLLENKNHETVA-- 1237
Query: 494 TESKRSVRTLKEEVQKLDDLYQQKIKEAE--EEDEKCASELESLEKHKHLLESTVNQGLS 551
+ L E +L+ Y Q +KE E + D K L+SL L S + Q
Sbjct: 1238 ----AEYKKLCGENDRLNHTYSQLLKETEVLQTDHK---NLKSL-----LNNSKLEQTRL 1285
Query: 552 EAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQI 604
EA E ++ +YQ + T+T+ NN LL + ++ +HL +QI
Sbjct: 1286 EA--EFSKLKEQYQQLDITSTKL-----NNQCELLSQLKGNLEEENRHLLDQI 1331
Score = 37.7 bits (86), Expect = 0.033
Identities = 45/189 (23%), Positives = 82/189 (43%), Gaps = 17/189 (8%)
Query: 247 NAELQSKLKDLFNVDAFKL---ESLEAKNRAL---NEQIARLEQEREKEPNRLESLRKLK 300
N+ L S+ L N +A L SLE +N ++ E + L K+ +LE L + +
Sbjct: 1111 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1170
Query: 301 AS-LQGDVQKYQAYMS---NLESHSAILDQKLNGLNEEIARVE-------LECETIKQEN 349
AS + + K+ S NLE L+ + N L ++ ++E +E E + EN
Sbjct: 1171 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIE 409
+ + K + +R+NH ++L + L D + + L N +L+ R +
Sbjct: 1231 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290
Query: 410 TQLAEYHKL 418
+Y +L
Sbjct: 1291 KLKEQYQQL 1299
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 77.8 bits (190), Expect = 3e-14
Identities = 87/386 (22%), Positives = 172/386 (44%), Gaps = 49/386 (12%)
Query: 248 AELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPN-RLESLRKLKASLQGD 306
A+L+ ++ L +++ LE +N LN+ ++ L Q + R++ + K L
Sbjct: 536 AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 307 VQKYQAYMSNLESHSAILDQKLNGLNEEIAR---VELECETIKQENTRLQNIIDNQKYSV 363
+++ + +S +E + ++L E+ R +E E +++EN LQ I N K +
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 364 ADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLK 423
IE + E +EL++ KL K L++ + L +L+
Sbjct: 656 EKIEALEQENSELERENRKLKKTLDS-------------------------FKNLTFQLE 690
Query: 424 LIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEE-----EINKALNK 478
+ K + E++ N E+ C AQ+ + KEL +E E+ E+ KA K
Sbjct: 691 SLEKENSQLDEENLELRRNVES-LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 479 K--------MGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCAS 530
K GL+ ++L + S + ++ L+ E+Q L ++ Q +++ EE + +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSK 808
Query: 531 ELESLEKHKHLLESTVNQGLSEAMNELDAVQ---REYQLVVQTTTEERRKVGNNLQRLLE 587
LE LEK LE +Q L + +L+ R+ + TT EE NL++ +
Sbjct: 809 RLEQLEKENKSLEQETSQ-LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 588 MVATHVGSVEKHLEEQIAKVDREYEE 613
++ +G + K ++ ++++E +E
Sbjct: 868 TLSKEIG-IYKESCVRLKELEKENKE 892
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/391 (24%), Positives = 175/391 (44%), Gaps = 43/391 (10%)
Query: 214 ETEDGIMHNKLF-LDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKN 272
E E+ ++ K+ L T + E+ + N +L+ L N+ F+LESLE +N
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL-TFQLESLEKEN 696
Query: 273 RALNEQ-----------------IARLEQEREKEPNRLESLRK----LKASLQGDVQKYQ 311
L+E+ +A+L+ E ++ + E L+K LKAS + ++ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLE 755
Query: 312 AYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINH 371
L+ + L + L N++I ++E E + ++ EN LQ ++ K S +E++
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEK 815
Query: 372 ERNELQQTINKLTKD---LEAEQQKLWNE-ELKYARGKEAIETQLAEYHKLARKLKLIPK 427
E L+Q ++L KD LE E ++L + E+K +E + L ++ K + K
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK----DTTLEENNVKIGNLEKENKTLSK 871
Query: 428 GAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLE 487
K +K E LVK + + +K L+ E+ +++ L K + + LE
Sbjct: 872 EIGIYKESCVRLK-ELEKENKELVK---RATIDIKTLVTLREDLVSEKL-KTQQMNNDLE 926
Query: 488 QLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVN 547
+L + + + L + Q DD Y K+ E++ E LE E+ LE+ +
Sbjct: 927 KLTHELEKIGLNKERLLHDEQSTDDRY--KLLESKLE-STLKKSLEIKEEKIAALEARLE 983
Query: 548 QGLS---EAMNELDAVQREYQLVVQTTTEER 575
+ + + EL V++ Y+ + Q EER
Sbjct: 984 ESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014
Score = 44.7 bits (104), Expect = 3e-04
Identities = 73/406 (17%), Positives = 179/406 (44%), Gaps = 43/406 (10%)
Query: 264 KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLES--HS 321
K+ L + EQ+ +QE E+ L+ L++ +L D + + Y L++
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 322 AI----LDQKLNGLNEEIARVEL---ECETIKQEN-------TRLQNIIDNQKYSVADIE 367
A+ L+ +++ E + +E E +K++N T L++ ++ + +
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 368 RINHERNELQQTINKLTKDLEAEQQKLW-----NEELKYARGKEAIETQLA---EYHKLA 419
+ E +L+ ++ + + + +++K+ N L+ A+ K++++ L E +++
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ-KQSMDESLHLGWELEQIS 437
Query: 420 RKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRA--QVYVPLKELLNETEEEINKALN 477
R +L + + S G++ E ++ L+K Q E L T + + +
Sbjct: 438 RTSEL-SEAPQKSLGHEVN-----ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 478 KKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEK 537
K + +E ++L+ + + + K+ +Q +L + +KE + ++ + E+ E+
Sbjct: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
Query: 538 HKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVE 597
+LE N+ L++ ++ L ++ Q+ + ++ K L ++ ++ + +E
Sbjct: 552 QIKILEQE-NEHLNQTVSSL---RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 598 KHLEEQIAKVDREYEEC--MSEDLSENIKEIRDKYE---KKATLIK 638
+ QI K Y+E +E+L + + + E KK T +K
Sbjct: 608 FE-KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
Score = 42.7 bits (99), Expect = 0.001
Identities = 81/353 (22%), Positives = 144/353 (40%), Gaps = 68/353 (19%)
Query: 266 ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
ES E L + +E ER +L+ K +L+ +++ + +NL++ L
Sbjct: 1032 ESQETTRELLKVKDRLIEVERNNA-----TLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
Query: 326 QKLNGLNEEIARVELECETIKQENTRLQN-----------IIDNQKYSVADIERINHERN 374
++ L E+ ++ + ++ EN+ L + ++ Q + E + ER
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146
Query: 375 ELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKG 434
+L+ + L KD +E+L+ E Q +EY L K G S
Sbjct: 1147 DLKSLYDSLIKD---------HEKLELLH-----ERQASEYESLISK-----HGTLKSAH 1187
Query: 435 YDFEIKFNP-EAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMI 493
+ E++ E N L+K + Q+ E E++ K +KM LE+ + A
Sbjct: 1188 KNLEVEHRDLEDRYNQLLKQKGQL---------EDLEKMLKVEQEKMLLENKNHETVA-- 1236
Query: 494 TESKRSVRTLKEEVQKLDDLYQQKIKEAE--EEDEKCASELESLEKHKHLLESTVNQGLS 551
+ L E +L+ Y Q +KE E + D K L+SL L S + Q
Sbjct: 1237 ----AEYKKLCGENDRLNHTYSQLLKETEVLQTDHK---NLKSL-----LNNSKLEQTRL 1284
Query: 552 EAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQI 604
EA E ++ +YQ + T+T+ NN LL + ++ +HL +QI
Sbjct: 1285 EA--EFSKLKEQYQQLDITSTKL-----NNQCELLSQLKGNLEEENRHLLDQI 1330
Score = 37.7 bits (86), Expect = 0.033
Identities = 45/189 (23%), Positives = 82/189 (43%), Gaps = 17/189 (8%)
Query: 247 NAELQSKLKDLFNVDAFKL---ESLEAKNRAL---NEQIARLEQEREKEPNRLESLRKLK 300
N+ L S+ L N +A L SLE +N ++ E + L K+ +LE L + +
Sbjct: 1110 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1169
Query: 301 AS-LQGDVQKYQAYMS---NLESHSAILDQKLNGLNEEIARVE-------LECETIKQEN 349
AS + + K+ S NLE L+ + N L ++ ++E +E E + EN
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1229
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIE 409
+ + K + +R+NH ++L + L D + + L N +L+ R +
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1289
Query: 410 TQLAEYHKL 418
+Y +L
Sbjct: 1290 KLKEQYQQL 1298
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/488 (22%), Positives = 205/488 (42%), Gaps = 105/488 (21%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNR---------ALNEQIARLEQEREKEPNRLE 294
D ++L++ + L ++DA + S E K+ A +QI LE E+ E ++
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
Query: 295 SL------RKLK-ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELEC-ETI- 345
S+ R+LK +LQ ++ + LE IL +K +EE V+ ET+
Sbjct: 774 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 833
Query: 346 -----KQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLE---AEQQKL--- 394
+++ L + ++ + ++AD+E E++E ++ + K + LE AE K+
Sbjct: 834 KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 893
Query: 395 -------WNEELKYARG----------------------------------KEAIETQLA 413
N+EL+ +EA +
Sbjct: 894 NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953
Query: 414 EYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEIN 473
E +L RKL + K E S E+K E + ++ L++ L +TE+++
Sbjct: 954 EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK 1013
Query: 474 KALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQK------IKEAEEEDEK 527
A + GL LE+L ++K + +T ++ +Q ++ + ++K +++ ++ + K
Sbjct: 1014 GAREENSGLLQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072
Query: 528 CASEL-----------ESLEKHKHLLESTVNQGLSEAMNELD-----AVQREYQLVVQTT 571
+EL E L K K LL + NQ + E E++ A Q+ QL
Sbjct: 1073 LQNELDTLKENNLKNVEELNKSKELL-TVENQKMEEFRKEIETLKQAAAQKSQQL--SAL 1129
Query: 572 TEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYE 631
EE K+ L R + V +H + LEE+ + ++ + E + K I+D E
Sbjct: 1130 QEENVKLAEELGRSRDEVTSH-----QKLEEERSVLNNQLLEMKKRE----SKFIKDADE 1180
Query: 632 KKATLIKS 639
+KA+L KS
Sbjct: 1181 EKASLQKS 1188
Score = 51.2 bits (121), Expect = 3e-06
Identities = 109/476 (22%), Positives = 196/476 (41%), Gaps = 103/476 (21%)
Query: 268 LEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLE-------SH 320
LEAK L + ++E+ + N+LE ++ LQ V++ +LE S
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
Query: 321 SAILDQKLNGLNEEIARVELECETIKQEN------TRLQNIIDNQKYSVADIERINHER- 373
L++ L +E+A + E+ K + LQ I Q+ ++ R +H+R
Sbjct: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQE--KLEVTRTDHQRE 523
Query: 374 --------NELQQTINKLTKDLEAEQQKL--WNEELK-------------YARGKEAIET 410
++T K K L +KL NE LK A K +ET
Sbjct: 524 ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 583
Query: 411 QLAEYHKLARKLKL-IPKGAENSKGYDFEIKFNPE----------------------AGA 447
+A + + +LK+ KG E+K E A A
Sbjct: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
Query: 448 NCLVKYRAQVYVPLKELLNETE---EEINKALNKKM-GLEDTLEQLNAM--------ITE 495
+ RA++ +KE N E +++KA ++ + +EDTL +L + +
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 496 SKRSVRT---------LKEEVQKLDDL--YQQKIKEAEEEDEKCASELESLEKHKHLLES 544
+K + +T LK +KL DL ++ E + E +K +LE+ EK LE
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 545 TVNQGLSEAMNELDAVQ-REYQLV-VQTTTEERRKVGNNLQRLLEMV-------ATHVGS 595
N S+A + +Q RE +L +Q E +V L++ L+++ + S
Sbjct: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
Query: 596 VEKHLEEQIAKVDREYE---------ECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
V++ ++E + K+ ++ E E + E+L++ + R+K E++ LIK+ E+
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEK 879
Score = 50.4 bits (119), Expect = 5e-06
Identities = 91/473 (19%), Positives = 197/473 (41%), Gaps = 62/473 (13%)
Query: 193 KIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQS 252
K+ A KE+S + W + E I ++ ++ + SF G + AEL++
Sbjct: 562 KLEHANKENSDVI---ALWKSKLETAIASHQQAME---ELKVSFSKGLGTETAEFAELKT 615
Query: 253 KLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLR-KLKASLQGDVQKYQ 311
+++ + ++E+L+ N+Q + ER +E+LR KL ++ +
Sbjct: 616 QIEKMRLDYQHEIENLQ------NQQ----DSERAAHAKEMEALRAKLMKVIKEKENSLE 665
Query: 312 AYMSNLES----HSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDN-------QK 360
A S L+ H ++ LN L E +V+ E E ++ + +IDN +
Sbjct: 666 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK-ELEVLQAKCNEQTKVIDNFTSQLKATE 724
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
+ D++ + +E + + KL + LEA ++++ + L+ + E+ + R
Sbjct: 725 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI--KHLEIEKNAESSKASSITRELQGR 782
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM 480
+LKL + + + + ++ Q+ LKE E EE A++ +
Sbjct: 783 ELKLT----------NLQENLSEVSQVKETLEKELQI---LKEKFAEASEE---AVSVQR 826
Query: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL---YQQKIKEAEEEDEKCASELESLEK 537
+++T+ +L+ + + L +++KL + + K +E +E +E+ E LE
Sbjct: 827 SMQETVNKLH----QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
Query: 538 ---HKHLLESTVNQGLSEAMNELDAVQR---EYQLVVQTTTEERRKVGNNLQRLLEMVAT 591
+ + L++ +EL +R E QL + E + +++ +
Sbjct: 883 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942
Query: 592 HVGSVEKHLEEQIAKVDREYE--ECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
K EE+ +++R+ E E +E++ +YE+ + K+ E
Sbjct: 943 SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995
Score = 49.3 bits (116), Expect = 1e-05
Identities = 83/405 (20%), Positives = 166/405 (40%), Gaps = 56/405 (13%)
Query: 216 EDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRAL 275
E+ K D T+K +S A +E EL+ KL D LE K
Sbjct: 924 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD-----------LEKKMETS 972
Query: 276 NEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEI 335
+ Q L+ E+ + ++ K++ + NL+ + KL G EE
Sbjct: 973 HNQCQELKARYERATSETKT-------------KHEEILQNLQKTLLDTEDKLKGAREEN 1019
Query: 336 ARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNE-------LQQTINKLTKDLE 388
+ + E E ++++ + + + ++ +E++ E+ E +QT KL +L+
Sbjct: 1020 SGLLQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1078
Query: 389 A-EQQKLWN-EELKYARGKEAIETQ-LAEYHKLARKLK--LIPKGAENSKGYDFEIKFNP 443
++ L N EEL ++ +E Q + E+ K LK K + S + +K
Sbjct: 1079 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1138
Query: 444 EAGAN--------CLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITE 495
E G + L + R+ + L E+ + I A +K L+ ++ +A++TE
Sbjct: 1139 ELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
Query: 496 SKRSVRTLKEEVQKL--DDLYQQKIKEAEE--EDEKCASELE------SLEKHKHLLEST 545
+ L+ EV L ++ + + + E +K EL+ L+++K L S+
Sbjct: 1199 KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1258
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVA 590
++A + A + + + + +RK +L+ +EM++
Sbjct: 1259 SGNTDTQADEDERAQESQIDFLNSVIVDLQRK-NQDLKMKVEMMS 1302
Score = 47.4 bits (111), Expect = 4e-05
Identities = 65/370 (17%), Positives = 153/370 (41%), Gaps = 26/370 (7%)
Query: 297 RKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNII 356
R AS + + +S+ S + +L + + +I+ E +K++ ++ ++
Sbjct: 309 RSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLL 368
Query: 357 DNQKYSVADIERINHERNELQQTI-------NKLTKDLEAEQQKLWNEELKYARGKEAIE 409
+ A++ + E++Q + ++ +LEA+ +L R K +
Sbjct: 369 AERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELL 428
Query: 410 TQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVK----YRAQVYVPLKELL 465
QL E + L+ + +KG D E+ E ++ R Q L+ L
Sbjct: 429 NQLEEEKRKVEDLQFRVEEESITKG-DLEVATVSEKSRIMELEKDLALRVQEVAELRRRL 487
Query: 466 --NETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEE 523
N+ +++ +L+ + E+L T+ +R + +LKE ++ +Q++IK
Sbjct: 488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 547
Query: 524 EDEKCASELESLE-KHKH----------LLESTVNQGLSEAMNELDAVQREYQLVVQTTT 572
EK + E ESL+ K +H L +S + ++ ++ ++ + + T T
Sbjct: 548 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 607
Query: 573 EERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEK 632
E ++ ++++ + +++ + + A +E E + L + IKE + E
Sbjct: 608 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM-EALRAKLMKVIKEKENSLEA 666
Query: 633 KATLIKSSEE 642
+ + +E+
Sbjct: 667 IRSKLDKAED 676
Score = 41.6 bits (96), Expect = 0.002
Identities = 57/287 (19%), Positives = 122/287 (42%), Gaps = 46/287 (16%)
Query: 265 LESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAIL 324
LE + N L ++ L++ K L ++L +++++ + L+ +A
Sbjct: 1063 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1122
Query: 325 DQKLNGLNEEIARVELEC----------ETIKQENTRLQN-IIDNQKYSVADIERINHER 373
Q+L+ L EE ++ E + +++E + L N +++ +K I+ + E+
Sbjct: 1123 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
Query: 374 NELQQTIN---KLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAE 430
LQ++I+ L + +AE +KL N E+ RG+ A L H + + L+ E
Sbjct: 1183 ASLQKSISITSALLTEKDAELEKLRN-EVTVLRGENASAKSL---HSVVQTLESDKVKLE 1238
Query: 431 -NSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQL 489
K + ++K N ++L + + +A + E ++ L
Sbjct: 1239 LKVKNLELQLKENK------------------RQLSSSSGNTDTQADEDERAQESQIDFL 1280
Query: 490 NAMITESKRSVRTLKEEVQKL---------DDLYQQKIKEAEEEDEK 527
N++I + +R + LK +V+ + DDL + E++ +K
Sbjct: 1281 NSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKK 1327
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/488 (22%), Positives = 205/488 (42%), Gaps = 105/488 (21%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNR---------ALNEQIARLEQEREKEPNRLE 294
D ++L++ + L ++DA + S E K+ A +QI LE E+ E ++
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 808
Query: 295 SL------RKLK-ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELEC-ETI- 345
S+ R+LK +LQ ++ + LE IL +K +EE V+ ET+
Sbjct: 809 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 868
Query: 346 -----KQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLE---AEQQKL--- 394
+++ L + ++ + ++AD+E E++E ++ + K + LE AE K+
Sbjct: 869 KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 928
Query: 395 -------WNEELKYARG----------------------------------KEAIETQLA 413
N+EL+ +EA +
Sbjct: 929 NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988
Query: 414 EYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEIN 473
E +L RKL + K E S E+K E + ++ L++ L +TE+++
Sbjct: 989 EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK 1048
Query: 474 KALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQK------IKEAEEEDEK 527
A + GL LE+L ++K + +T ++ +Q ++ + ++K +++ ++ + K
Sbjct: 1049 GAREENSGLLQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107
Query: 528 CASEL-----------ESLEKHKHLLESTVNQGLSEAMNELD-----AVQREYQLVVQTT 571
+EL E L K K LL + NQ + E E++ A Q+ QL
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELL-TVENQKMEEFRKEIETLKQAAAQKSQQL--SAL 1164
Query: 572 TEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYE 631
EE K+ L R + V +H + LEE+ + ++ + E + K I+D E
Sbjct: 1165 QEENVKLAEELGRSRDEVTSH-----QKLEEERSVLNNQLLEMKKRE----SKFIKDADE 1215
Query: 632 KKATLIKS 639
+KA+L KS
Sbjct: 1216 EKASLQKS 1223
Score = 53.5 bits (127), Expect = 6e-07
Identities = 75/383 (19%), Positives = 166/383 (43%), Gaps = 46/383 (12%)
Query: 282 LEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAIL----DQKLNGLNEEIAR 337
L++ +++ +E L + + +V K +++ +E A+ DQ + L ++ +
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 338 VELECETIKQENTRLQNIIDNQKYSVADIE-RINHERNELQQTINKLTK-DLEAEQQKLW 395
+ E +E L N ++ +K V D++ R+ E +TK DLE + +
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE---------SITKGDLETQTK--- 460
Query: 396 NEELKYARGKEAIETQLAEY---HKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVK 452
L++AR KE ++ L E KL R+L+ + K E++ + +
Sbjct: 461 ---LEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKD--------LA 509
Query: 453 YRAQVYVPLKELL--NETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKL 510
R Q L+ L N+ +++ +L+ + E+L T+ +R + +LKE
Sbjct: 510 LRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR 569
Query: 511 DDLYQQKIKEAEEEDEKCASELESLE-KHKH----------LLESTVNQGLSEAMNELDA 559
++ +Q++IK EK + E ESL+ K +H L +S + ++ ++
Sbjct: 570 EETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEE 629
Query: 560 VQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDL 619
++ + + T T E ++ ++++ + +++ + + A +E E + L
Sbjct: 630 LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM-EALRAKL 688
Query: 620 SENIKEIRDKYEKKATLIKSSEE 642
+ IKE + E + + +E+
Sbjct: 689 MKVIKEKENSLEAIRSKLDKAED 711
Score = 50.4 bits (119), Expect = 5e-06
Identities = 91/473 (19%), Positives = 197/473 (41%), Gaps = 62/473 (13%)
Query: 193 KIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQS 252
K+ A KE+S + W + E I ++ ++ + SF G + AEL++
Sbjct: 597 KLEHANKENSDVI---ALWKSKLETAIASHQQAME---ELKVSFSKGLGTETAEFAELKT 650
Query: 253 KLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLR-KLKASLQGDVQKYQ 311
+++ + ++E+L+ N+Q + ER +E+LR KL ++ +
Sbjct: 651 QIEKMRLDYQHEIENLQ------NQQ----DSERAAHAKEMEALRAKLMKVIKEKENSLE 700
Query: 312 AYMSNLES----HSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDN-------QK 360
A S L+ H ++ LN L E +V+ E E ++ + +IDN +
Sbjct: 701 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK-ELEVLQAKCNEQTKVIDNFTSQLKATE 759
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
+ D++ + +E + + KL + LEA ++++ + L+ + E+ + R
Sbjct: 760 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI--KHLEIEKNAESSKASSITRELQGR 817
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM 480
+LKL + + + + ++ Q+ LKE E EE A++ +
Sbjct: 818 ELKLT----------NLQENLSEVSQVKETLEKELQI---LKEKFAEASEE---AVSVQR 861
Query: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL---YQQKIKEAEEEDEKCASELESLEK 537
+++T+ +L+ + + L +++KL + + K +E +E +E+ E LE
Sbjct: 862 SMQETVNKLH----QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 917
Query: 538 ---HKHLLESTVNQGLSEAMNELDAVQR---EYQLVVQTTTEERRKVGNNLQRLLEMVAT 591
+ + L++ +EL +R E QL + E + +++ +
Sbjct: 918 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977
Query: 592 HVGSVEKHLEEQIAKVDREYE--ECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
K EE+ +++R+ E E +E++ +YE+ + K+ E
Sbjct: 978 SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 1030
Score = 49.3 bits (116), Expect = 1e-05
Identities = 83/405 (20%), Positives = 166/405 (40%), Gaps = 56/405 (13%)
Query: 216 EDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRAL 275
E+ K D T+K +S A +E EL+ KL D LE K
Sbjct: 959 ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD-----------LEKKMETS 1007
Query: 276 NEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEI 335
+ Q L+ E+ + ++ K++ + NL+ + KL G EE
Sbjct: 1008 HNQCQELKARYERATSETKT-------------KHEEILQNLQKTLLDTEDKLKGAREEN 1054
Query: 336 ARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNE-------LQQTINKLTKDLE 388
+ + E E ++++ + + + ++ +E++ E+ E +QT KL +L+
Sbjct: 1055 SGLLQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1113
Query: 389 A-EQQKLWN-EELKYARGKEAIETQ-LAEYHKLARKLK--LIPKGAENSKGYDFEIKFNP 443
++ L N EEL ++ +E Q + E+ K LK K + S + +K
Sbjct: 1114 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1173
Query: 444 EAGAN--------CLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITE 495
E G + L + R+ + L E+ + I A +K L+ ++ +A++TE
Sbjct: 1174 ELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1233
Query: 496 SKRSVRTLKEEVQKL--DDLYQQKIKEAEE--EDEKCASELE------SLEKHKHLLEST 545
+ L+ EV L ++ + + + E +K EL+ L+++K L S+
Sbjct: 1234 KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSS 1293
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVA 590
++A + A + + + + +RK +L+ +EM++
Sbjct: 1294 SGNTDTQADEDERAQESQIDFLNSVIVDLQRK-NQDLKMKVEMMS 1337
Score = 43.1 bits (100), Expect = 8e-04
Identities = 104/511 (20%), Positives = 202/511 (39%), Gaps = 138/511 (27%)
Query: 268 LEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQK 327
LEAK L + ++E+ + N+LE ++ LQ V++ +LE+ + + +
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR 465
Query: 328 LNGLNEEIARVELECETIKQE--NTRLQNIIDNQKYSVADIE------------------ 367
+ L + + + + + +++E +TR+ + ++K + ++E
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTRVATV--SEKSRIMELEKDLALRVQEVAELRRRLE 523
Query: 368 ----------------------------RINHER---------NELQQTINKLTKDLEAE 390
R +H+R ++T K K L
Sbjct: 524 SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTA 583
Query: 391 QQKL--WNEELK-------------YARGKEAIETQLAEYHKLARKLKL-IPKGAENSKG 434
+KL NE LK A K +ET +A + + +LK+ KG
Sbjct: 584 TEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETA 643
Query: 435 YDFEIKFNPE----------------------AGANCLVKYRAQVYVPLKELLNETE--- 469
E+K E A A + RA++ +KE N E
Sbjct: 644 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIR 703
Query: 470 EEINKALNKKM-GLEDTLEQLNAM--------ITESKRSVRT---------LKEEVQKLD 511
+++KA ++ + +EDTL +L + ++K + +T LK +KL
Sbjct: 704 SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLL 763
Query: 512 DL--YQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQ-REYQLV- 567
DL ++ E + E +K +LE+ EK LE N S+A + +Q RE +L
Sbjct: 764 DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN 823
Query: 568 VQTTTEERRKVGNNLQRLLEMV-------ATHVGSVEKHLEEQIAKVDREYE-------- 612
+Q E +V L++ L+++ + SV++ ++E + K+ ++ E
Sbjct: 824 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 883
Query: 613 -ECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
E + E+L++ + R+K E++ LIK+ E+
Sbjct: 884 LEKLRENLADMEAKFREKDEREEQLIKAKEK 914
Score = 41.6 bits (96), Expect = 0.002
Identities = 57/287 (19%), Positives = 122/287 (42%), Gaps = 46/287 (16%)
Query: 265 LESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAIL 324
LE + N L ++ L++ K L ++L +++++ + L+ +A
Sbjct: 1098 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 325 DQKLNGLNEEIARVELEC----------ETIKQENTRLQN-IIDNQKYSVADIERINHER 373
Q+L+ L EE ++ E + +++E + L N +++ +K I+ + E+
Sbjct: 1158 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217
Query: 374 NELQQTIN---KLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAE 430
LQ++I+ L + +AE +KL N E+ RG+ A L H + + L+ E
Sbjct: 1218 ASLQKSISITSALLTEKDAELEKLRN-EVTVLRGENASAKSL---HSVVQTLESDKVKLE 1273
Query: 431 -NSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQL 489
K + ++K N ++L + + +A + E ++ L
Sbjct: 1274 LKVKNLELQLKENK------------------RQLSSSSGNTDTQADEDERAQESQIDFL 1315
Query: 490 NAMITESKRSVRTLKEEVQKL---------DDLYQQKIKEAEEEDEK 527
N++I + +R + LK +V+ + DDL + E++ +K
Sbjct: 1316 NSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKK 1362
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 75.5 bits (184), Expect = 1e-13
Identities = 94/408 (23%), Positives = 175/408 (42%), Gaps = 42/408 (10%)
Query: 251 QSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKY 310
Q L DL V+ K+ L N L +Q LE E+E L + K L+GD++
Sbjct: 1008 QQTLDDL-QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066
Query: 311 QAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
Q + +LE+ +++KL E+++++ + + + + + Q I + + ++E
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126
Query: 371 HERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL-----AEYHKLARKLKLI 425
+ L+ I K DL E +++ +E L+ A G + + ++ AE+ K+ R L+
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEI-SERLEEASGATSAQIEMNKKREAEFQKMRRDLE-- 1183
Query: 426 PKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDT 485
E EA A L K +A L E ++ + K +K L+
Sbjct: 1184 ------------EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 486 LEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLEST 545
++ + + I +S ++ + ++D + E + +DE+ + L K L+ T
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVED----QFSEIKAKDEQQTQLIHDLNMQKARLQ-T 1286
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTT----------EERRKVGNNLQRLLEMVATHVGS 595
N LS + E +++ + Q T EE K N + L+
Sbjct: 1287 QNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 596 V-EKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
+ E++ EEQ AK E + +S+ SE + + R KYE A I+ +EE
Sbjct: 1347 LREQYEEEQEAKA--ELQRALSKANSE-VAQWRTKYETDA--IQRTEE 1389
Score = 67.0 bits (162), Expect = 5e-11
Identities = 87/464 (18%), Positives = 185/464 (39%), Gaps = 83/464 (17%)
Query: 245 EMNAELQSKL----------KDLFNVDAF-KLESLEAKNRALNEQIARLEQEREKEPNRL 293
E AELQ L + + DA + E LE + L +++ E+ E ++
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKC 1415
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIA---------RVELEC-- 342
SL K K LQG+V+ + + A LD+K ++ +A + ELE
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475
Query: 343 ------------------------ETIKQENTRLQNIIDNQKYSVADIER---------- 368
ET+++EN LQ I + +A+ +
Sbjct: 1476 KESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKK 1535
Query: 369 -INHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAE-----------YH 416
+ E+++LQ + ++ LE E+ K+ +L+ ++ K ++ ++ E
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Query: 417 KLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV-------KYRAQVYVPLKEL---LN 466
+ A L+ + S+ +K E N + + A+ L+ + L
Sbjct: 1596 RAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 467 ETEEEINKALNKKMGLEDTL---EQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEE 523
+++ ++ AL L++ L E+ N ++ E ++ E+ ++ L +Q++ +A +
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 524 EDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQ 583
+ S+ SL K LE+ + Q +E N + + + + T + + L+
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAIT-DAAMMAEELK 1774
Query: 584 RLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIR 627
+ + + H+ ++K+LE+ + + +E L K+I+
Sbjct: 1775 KEQD-TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ 1817
Score = 63.5 bits (153), Expect = 6e-10
Identities = 104/449 (23%), Positives = 202/449 (44%), Gaps = 77/449 (17%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFN--------VDAFK 264
EE +G++ +K+ L+ +K + +EMN+EL +K ++L + +D +
Sbjct: 906 EERCEGLIKSKILLEAKVK---ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 265 L---------ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMS 315
L + E K + L+E++ LE+ + L K K SLQ + +Q +
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEE-------NISKLTKEKKSLQ---EAHQQTLD 1012
Query: 316 NLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIER----INH 371
+L+ + + K+NGL + A++E Q+ L+ ++ +K AD+ER +
Sbjct: 1013 DLQ----VEEDKVNGLIKINAKLE-------QQTDDLEGSLEQEKKLRADLERAKRKLEG 1061
Query: 372 ERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAEN 431
+ Q++I L D + ++KL +E + ++ + I+ + + +K+K + E
Sbjct: 1062 DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE 1121
Query: 432 SKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEE---------EINK---ALNKK 479
+ EI+ A + K R+ + L+E+ EE E+NK A +K
Sbjct: 1122 ---LEEEIEAEHTLRAK-IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177
Query: 480 M--GLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDLYQQKIKEAEE---EDEKCAS 530
M LE+ Q A ++ SV L E++ L + Q+ KE E E + AS
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
Query: 531 ELESLEKHKHLLESTVNQGLSEAMNELDAV-QREYQLVVQTTTEERRKVGNN--LQRLLE 587
+E+L K K +E T + + + +E+ A +++ QL+ ++ R N L +E
Sbjct: 1238 NIEALSKSKSNIERTC-RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 588 MVATHVGSVEKH---LEEQIAKVDREYEE 613
+ + + K L +Q+ ++ R+ EE
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQMEE 1325
Score = 59.3 bits (142), Expect = 1e-08
Identities = 93/449 (20%), Positives = 181/449 (40%), Gaps = 75/449 (16%)
Query: 246 MNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQG 305
+ A+++ + DL E LE + A + QI + ++RE E +K++ L+
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQI-EMNKKREAE------FQKMRRDLEE 1184
Query: 306 DVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVAD 365
+++A + L A + L E+I ++ + +++E + L+ ID+ ++
Sbjct: 1185 ATLQHEATAATLRKKQA---DSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA 1241
Query: 366 IERINHERNELQQTINKLTKDLEA--EQQKLWNEELKYARGKEAIETQLAEY-HKLARKL 422
+ + +T+ +++A EQQ +L + + ++TQ E H++ K
Sbjct: 1242 LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKAR--LQTQNGELSHRVEEKE 1299
Query: 423 KLIPKGAENSKGYDFEIK-----FNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALN 477
LI + ++ + +++ E A + + Q +LL E EE +A
Sbjct: 1300 SLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA-- 1357
Query: 478 KKMGLEDTLEQLNAMITESKRSVRT----LKEEVQKLDDLYQQKIKEAEEEDEKCASELE 533
K L+ L + N+ + + + T EE+++ Q+++EAEE E S+
Sbjct: 1358 -KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 534 SLEKHKHLLESTV-------------------------------NQGLSEAMNELDAVQR 562
SLEK K L+ V Q L E+ EL+A Q+
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 563 E--------------YQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVD 608
E Y+ VV E R+ NLQ + + + K+L+E A+
Sbjct: 1477 ESRSLSTELFKMRNAYEEVVD-QLETLRRENKNLQEEISDLTEQIAETGKNLQE--AEKT 1533
Query: 609 REYEECMSEDLSENIKEIRDKYEKKATLI 637
++ E DL ++E+ E + + I
Sbjct: 1534 KKLVEQEKSDLQVALEEVEGSLEHEESKI 1562
Score = 46.2 bits (108), Expect = 9e-05
Identities = 88/447 (19%), Positives = 187/447 (41%), Gaps = 87/447 (19%)
Query: 244 DEMNAELQS-------------KLKDLFNVDAFKLESLEAKNRALNEQIARLEQ---ERE 287
DE AEL++ K+++ + +LE+L +N+ L E+I+ L + E
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 288 KEPNRLESLRKL----KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELE-- 341
K E +KL K+ LQ +++ + + + ES + +L+ + E+ R +E
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKD 1584
Query: 342 --CETIKQENTR----LQNIIDNQKYSVADIERI------------------NHERNELQ 377
E +K+ + R LQ+++D + S D R+ N + E Q
Sbjct: 1585 EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQ 1644
Query: 378 QTINKLTKDLEAEQQKLWN--------------------------EELKYARGKEAIETQ 411
+ + + L+ Q L + EE+K A + +
Sbjct: 1645 KHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRR 1704
Query: 412 LAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEE 471
L+E L ++ ++N+ + + K + A C +A+V ++E N EE+
Sbjct: 1705 LSEQELLDASDRVQLLHSQNTSLINTKKKLEADI-AQC----QAEVENSIQESRN-AEEK 1758
Query: 472 INKALNKKMGLEDTLEQ---LNAMITESKRSV-RTLKEEVQKLDDLYQQKIKEAEEEDEK 527
KA+ + + L++ +A + K+++ +T+K+ +LD+ Q +K +++ +K
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 528 CASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLE 587
+ + LE L+ +G +EA+ +R+ + + E+ + + LQ L++
Sbjct: 1819 LENRVRELENE---LDVEQKRG-AEALKGAHKYERKVKEMTYQAEEDHKNI-LRLQDLVD 1873
Query: 588 MVATHVGSVEKHLEEQIAKVDREYEEC 614
+ V S ++ EE + + + C
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQANTQLSRC 1900
Score = 35.0 bits (79), Expect = 0.21
Identities = 43/174 (24%), Positives = 76/174 (43%), Gaps = 27/174 (15%)
Query: 461 LKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKE 520
+KE T+EE+ ++ ++ LE+ + L +Q+ +DL Q E
Sbjct: 856 MKEDFERTKEELARSEARRKELEEKMVSL-----------------LQEKNDLQLQVQSE 898
Query: 521 AE---EEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRK 577
E + +E+C E L K K LLE+ V + L+E + E + + E + ++
Sbjct: 899 TENLMDAEERC----EGLIKSKILLEAKVKE-LTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 578 VGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYE 631
+ ++ LE+ T V EKH E K E + E++S+ KE + E
Sbjct: 954 LKRDIDD-LELTLTKV-EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 74.7 bits (182), Expect = 2e-13
Identities = 99/445 (22%), Positives = 189/445 (42%), Gaps = 82/445 (18%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQ 304
E +E KL++ + + ++E L+ + AL +Q+ +++++ ++ +E+ R+
Sbjct: 804 EETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRR------ 857
Query: 305 GDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVA 364
D +S L++ LD +L L +E+ +V E T + E +RL + + +A
Sbjct: 858 -DATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMA 916
Query: 365 DIE----RINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
D+E ER+E++ + L D E + + EA++ Q+ E + AR
Sbjct: 917 DLEGHLQSAQKERDEMETHLQSLQFDKE--------QMVAVTEANEALKKQIEELQQEAR 968
Query: 421 KLKLIPKGAENSKGYDF-----EIKFNPEAGANC--LVKYRAQVYVPLKELLNETEEEIN 473
K K G D E+K +A N ++ R Q + KE + ++
Sbjct: 969 KAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLR 1028
Query: 474 K---ALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEA--------- 521
+ + + L + ++ L A + S L++E+Q++ L Q+++E+
Sbjct: 1029 AQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELED 1088
Query: 522 ---------------EEEDEKCASELE--------------SLEKHKHLLESTVNQGLSE 552
EE ++K A ELE +L +H +LE+ +
Sbjct: 1089 ELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETAL------ 1142
Query: 553 AMNELDAVQ--REYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKV--- 607
A E D VQ + Q V+Q EE R++ + +Q L + V L+EQ+A
Sbjct: 1143 AKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNS-LKEQVAAAKVE 1201
Query: 608 ---DREYEECMSEDLSENIKEIRDK 629
+R + + S +LSE KE++ K
Sbjct: 1202 AGHNRRHFKAASLELSEVKKELQAK 1226
Score = 55.1 bits (131), Expect = 2e-07
Identities = 88/432 (20%), Positives = 176/432 (40%), Gaps = 65/432 (15%)
Query: 234 ESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRAL---NEQIARLEQEREKEP 290
+S S D+ + +L+ + DL N+ LEAKN +L N + E++ ++
Sbjct: 464 DSLSSEVDTLKQSCWDLERAMTDLQNM-------LEAKNASLASSNNDLQVAEEQYQRLM 516
Query: 291 NRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENT 350
++E +++ S V + M+ L+S + + L ++ + E +++
Sbjct: 517 AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
Query: 351 RLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIET 410
Q Q+ ++A R+ + + ++T+ E KL N L ++ ET
Sbjct: 577 WYQ-----QQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSL----SQQLTET 627
Query: 411 QLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETE- 469
Q R +K + A +G + ++ + EA + + + V L+ L E E
Sbjct: 628 Q-------HRSMKEKGRIAAQLQGIEADM-LDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
Query: 470 --EEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEE------------------VQK 509
E + + + LE LEQ+ + + + + L++E Q
Sbjct: 680 ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQS 739
Query: 510 LD------DLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQRE 563
LD D Q ++ E + E + L+ K +LE+ + Q ELD R
Sbjct: 740 LDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAAL-QAAKSGKEELDRGARR 798
Query: 564 YQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENI 623
+ + T+E L++L E +A G VE HL+++ A + ++ ++ + L +
Sbjct: 799 LEEGTEETSE-------TLEKLREELAIKSGQVE-HLQQETAALKKQMQKIKEQFLQQ-- 848
Query: 624 KEIRDKYEKKAT 635
K + + Y + AT
Sbjct: 849 KVMVEAYRRDAT 860
Score = 49.7 bits (117), Expect = 8e-06
Identities = 73/385 (18%), Positives = 157/385 (40%), Gaps = 36/385 (9%)
Query: 248 AELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDV 307
A+LQ D+ + +A ++ EAK + E + R +E E E RL+ + ASL+ +
Sbjct: 640 AQLQGIEADMLDQEAAFMQIQEAKTM-VEEDLQRRLEEFEGERERLQRMADSAASLEQQL 698
Query: 308 QKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIE 367
++ + + + L Q+ L +++ + ++ +Q LQ D + + +++
Sbjct: 699 EQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQ 758
Query: 368 RINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLK---- 423
R + + LEA Q + + + RG +E E + KL+
Sbjct: 759 GEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELA 818
Query: 424 --------------LIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETE 469
+ K + K + K EA + Q+ LK +
Sbjct: 819 IKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATS-KDQLISELKATRKRLD 877
Query: 470 EEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCA 529
E+ + + M + A ++ R V +++ + L+ ++ A++E ++
Sbjct: 878 SELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEG----HLQSAQKERDEME 933
Query: 530 SELESL--EKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNL-QRLL 586
+ L+SL +K + + + N+ L + + EL Q+E + + ++ R++G++L
Sbjct: 934 THLQSLQFDKEQMVAVTEANEALKKQIEEL---QQEARKAITEQKQKMRRLGSDLTSAQK 990
Query: 587 EMVATH------VGSVEKHLEEQIA 605
EM H VG + + L+E +A
Sbjct: 991 EMKTKHKAYENAVGILSRRLQEALA 1015
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/350 (19%), Positives = 157/350 (44%), Gaps = 49/350 (14%)
Query: 250 LQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQK 309
L+ +L+++ + + +LE K L +++ R+K ES +KL L+ + K
Sbjct: 1061 LEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGK 1120
Query: 310 YQAY-MSN--LESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADI 366
SN L H++IL+ L ++ ++ L+ + + +
Sbjct: 1121 LTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAV--------------------L 1160
Query: 367 ERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGK----------EAIETQLAEYH 416
+R E +++ + L LE E++K+ + + + A K +A +L+E
Sbjct: 1161 QRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVK 1220
Query: 417 K-LARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKA 475
K L K L+ K ++ D +I+ + + +++A++ + L ++++++
Sbjct: 1221 KELQAKEHLVQK--LQAEADDLQIREGKHSQE--IAQFQAEL-AEARAQLQLLQKQLDEQ 1275
Query: 476 LNKKMGLEDTLEQLNAMITESKRSVRTLKEEV--------QKLDDLYQQKIKEAEEEDEK 527
L+K+ +E L + + +R +++LK+++ ++L+ L QQ ++ + E E
Sbjct: 1276 LSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGL-QQLLQNVKSELEM 1334
Query: 528 CASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRK 577
+L +K K +L++ V++ L M L ++ +L ++ + RK
Sbjct: 1335 AQEDLSMTQKDKFMLQAKVSE-LKNNMKTLLQQNQQLKLDLRRGAAKTRK 1383
Score = 42.4 bits (98), Expect = 0.001
Identities = 29/134 (21%), Positives = 69/134 (51%), Gaps = 15/134 (11%)
Query: 459 VPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKI 518
V L+ ET+EE+ + L +KM LE LE L+ +++ + L+ ++ L Q ++
Sbjct: 394 VSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQV 453
Query: 519 K---EAEEEDEKCASELESLEKH-----------KHLLESTVNQGLSEAMNELDAVQREY 564
+ +++ + +SE+++L++ +++LE+ N L+ + N+L + +Y
Sbjct: 454 ECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAK-NASLASSNNDLQVAEEQY 512
Query: 565 QLVVQTTTEERRKV 578
Q ++ + +R +
Sbjct: 513 QRLMAKVEDMQRSM 526
Score = 38.1 bits (87), Expect = 0.025
Identities = 65/298 (21%), Positives = 119/298 (39%), Gaps = 19/298 (6%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLES----LRKLKASLQ 304
E ++K L LE + K +L EQ+A + E ++ L ++K LQ
Sbjct: 1165 EEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQ 1224
Query: 305 GD---VQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETI-KQENTRL------QN 354
VQK QA +L+ Q++ E+A + + + KQ + +L
Sbjct: 1225 AKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQ 1284
Query: 355 IIDNQKYSVADIER-INHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLA 413
++N K+ V ER I + +L T + K+LE QQ L N + + +E +
Sbjct: 1285 EMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQK 1344
Query: 414 EYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEIN 473
+ L K+ + + + ++K + GA K R + T +I
Sbjct: 1345 DKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA---AKTRKEPKGEASSSNPATPIKIP 1401
Query: 474 KALNKKMGLEDTLEQLNAMITESKRSVRT-LKEEVQKLDDLYQQKIKEAEEEDEKCAS 530
LE+ L A+ E +++ + L++ Q++D L +Q + A E +S
Sbjct: 1402 DCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSS 1459
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 74.3 bits (181), Expect = 3e-13
Identities = 97/432 (22%), Positives = 183/432 (42%), Gaps = 56/432 (12%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALN----------EQIARLEQEREKEPNRL 293
DE+ A+L + K L L+ L+A+ +N +Q+ LE E+E
Sbjct: 986 DEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVR 1045
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQ 353
L + K L+GD++ Q + +LE+ LD++L + E+ + E + ++LQ
Sbjct: 1046 MDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQ 1105
Query: 354 NIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL- 412
+ + + ++E + + KL DL E +++ +E L+ A G +++ ++
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI-SERLEEAGGATSVQIEMN 1164
Query: 413 ----AEYHKLARKLK------------LIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQ 456
AE+ K+ R L+ L K A++ +I N + L K +++
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID-NLQRVKQKLEKEKSE 1223
Query: 457 VYVPLKELLNETEEEIN-KALNKKM--GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL 513
+ L ++ + E+ I KA +KM LED + + + E++RSV L + KL
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 514 YQQKIKEAEEEDEKCASEL--------ESLEKHKHLLESTVN------QGLSEAMNELDA 559
+ ++ +E+ E S+L + LE K LE V L A ++ D
Sbjct: 1284 NGELSRQLDEK-EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL 1342
Query: 560 VQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDL 619
++ +Y EE + LQR+L + V E + E EE + L
Sbjct: 1343 LREQY--------EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA-KKKL 1393
Query: 620 SENIKEIRDKYE 631
++ ++E + E
Sbjct: 1394 AQRLQEAEEAVE 1405
Score = 67.4 bits (163), Expect = 4e-11
Identities = 87/424 (20%), Positives = 174/424 (41%), Gaps = 79/424 (18%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLES----L 268
EE E+ L + E+ + S ++ LQ++++DL VD + + L
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM-VDVERSNAAAAAL 1442
Query: 269 EAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQ-AYMSNLESHSAILDQK 327
+ K R ++ +A +Q+ E+ + LES +K SL ++ K + AY +LE
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--------- 1493
Query: 328 LNGLNEEIARVELECETIKQENTRLQNIID-------NQKYSVADIERINH----ERNEL 376
ET K+EN LQ I + ++ ++E++ E+ EL
Sbjct: 1494 -------------HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 377 QQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYD 436
Q + + LE E+ K+ +L++ + K IE +LAE + + K
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK------------- 1587
Query: 437 FEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITES 496
+ +V L+ L+ N+AL K +E L ++ ++ +
Sbjct: 1588 ---------------RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 497 KRSVRTLKEEVQKLDDLY---QQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEA 553
R +++V+ L L Q ++ +A ++ + +E+ +LL++ L E
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE----LEEL 1688
Query: 554 MNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEE 613
++ +R +L Q E +V +LL T + + +K ++ ++++ E EE
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSERV-----QLLHSQNTSLINQKKKMDADLSQLQTEVEE 1743
Query: 614 CMSE 617
+ E
Sbjct: 1744 AVQE 1747
Score = 60.5 bits (145), Expect = 5e-09
Identities = 98/446 (21%), Positives = 189/446 (42%), Gaps = 66/446 (14%)
Query: 246 MNAELQSKLKDLFNVDAFKLESLEAK--------------NRALNEQIARLEQ------- 284
+ ++LQ KLK+L E LEA+ +R L E RLE+
Sbjct: 1100 LGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSV 1159
Query: 285 EREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECET 344
+ E R +K++ L+ +++A + L A +L + + RV+ + E
Sbjct: 1160 QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219
Query: 345 IKQE-NTRLQNIIDNQKYSV---ADIERI--------NHERNELQQTINKLTKDLEAEQQ 392
K E L ++ N + + A++E++ N R++ ++T + DL +++
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET-QRSVNDLTSQRA 1278
Query: 393 KLWNEELKYARG---KEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANC 449
KL E + +R KEA+ +QL KL + + + + E+K A A+
Sbjct: 1279 KLQTENGELSRQLDEKEALISQLTR-----GKLTYTQQLEDLKRQLEEEVKAK-NALAHA 1332
Query: 450 LVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRT----LKE 505
L R +LL E EE +A K L+ L + N+ + + + T E
Sbjct: 1333 LQSARHDC-----DLLREQYEEETEA---KAELQRVLSKANSEVAQWRTKYETDAIQRTE 1384
Query: 506 EVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVN------QGLSEAMNELDA 559
E+++ Q+++EAEE E ++ SLEK KH L++ + + + A LD
Sbjct: 1385 ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1444
Query: 560 VQREYQLVV---QTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMS 616
QR + ++ + EE + + Q+ ++T + ++ EE + ++ E +
Sbjct: 1445 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE--N 1502
Query: 617 EDLSENIKEIRDKYEKKATLIKSSEE 642
++L E I ++ ++ I E+
Sbjct: 1503 KNLQEEISDLTEQLGSSGKTIHELEK 1528
Score = 60.1 bits (144), Expect = 6e-09
Identities = 83/405 (20%), Positives = 172/405 (42%), Gaps = 61/405 (15%)
Query: 233 YESFMSGADSFDEMNAELQS---KLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKE 289
YE S +S + L + KLK+ + LE+ + +N+ L E+I+ L ++
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSS 1519
Query: 290 PNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQEN 349
+ L K++ L+ + + Q S LE A L+ + +I R +LE IK E
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQ---SALEEAEASLEHE----EGKILRAQLEFNQIKAEI 1572
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEA-- 407
R K + D E +RN L + ++ L L+AE + NE L+ + E
Sbjct: 1573 ER--------KLAEKDEEMEQAKRNHL-RVVDSLQTSLDAETRSR-NEALRVKKKMEGDL 1622
Query: 408 --IETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELL 465
+E QL+ +++A AE K ++K L+ LL
Sbjct: 1623 NEMEIQLSHANRMA---------AEAQK----QVK-------------------SLQSLL 1650
Query: 466 NETEEEINKALNKKMGLEDTL---EQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAE 522
+T+ +++ A+ L++ + E+ N ++ +R + E+ ++ L +Q++ E
Sbjct: 1651 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS 1710
Query: 523 EEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNL 582
E + S+ SL K +++ ++Q +E + + + + T + + L
Sbjct: 1711 ERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT-DAAMMAEEL 1769
Query: 583 QRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIR 627
++ + + H+ ++K++E+ I + +E L K+++
Sbjct: 1770 KKEQD-TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813
Score = 59.3 bits (142), Expect = 1e-08
Identities = 97/429 (22%), Positives = 178/429 (41%), Gaps = 61/429 (14%)
Query: 252 SKLKDLFNVDAFKLESLEAKNRALNEQIARLEQERE--------------KEPNRLESLR 297
+ +K+ F LE EA+ + L E++ L QE+ R + L
Sbjct: 850 ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLI 909
Query: 298 KLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE-------IARVELECETIKQENT 350
K K L+ V++ + + E +A L K L +E I +EL +++E
Sbjct: 910 KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKH 969
Query: 351 RLQNIIDNQKYSVADIE----RINHERNELQQTINKLTKDLEAEQQK---LWNEELKYAR 403
+N + N +A ++ ++ E+ LQ+ + DL+AE+ K L ++K +
Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 404 GKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKE 463
+ +E L + K+ L+ + E ++K E+ + L + Q L E
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEG------DLKLTQESIMD-LENDKQQ----LDE 1078
Query: 464 LLNETEEEINKALNKKM--------GLEDTLEQLNAMITESKRSV---RTLKEEVQKL-D 511
L + + E+N ALN ++ L+ L++L A I E + + RT + +V+KL
Sbjct: 1079 RLKKKDFELN-ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRS 1137
Query: 512 DLYQ--QKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQ 569
DL + ++I E EE S + K + + + L EA + +A +
Sbjct: 1138 DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Query: 570 TTTEERRKVGNNLQRLLEMVATHVGSVEKHLE------EQIAKVDREYEECMSEDLSENI 623
+ E + +NLQR+ + + + L+ EQI K E+ M L + +
Sbjct: 1198 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK-MCRTLEDQM 1256
Query: 624 KEIRDKYEK 632
E R K E+
Sbjct: 1257 NEHRSKAEE 1265
Score = 53.1 bits (126), Expect = 8e-07
Identities = 98/465 (21%), Positives = 185/465 (39%), Gaps = 72/465 (15%)
Query: 196 TAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGA----DSFDEMNAELQ 251
T +KE+ + + EE ++ K L ++ + ++ A D + +L+
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 252 SKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQ 311
+K+K++ +LE E N L + +LE E + ++ L A ++ + +
Sbjct: 917 AKVKEMNE----RLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 312 AYMSNLESHSAILDQKLNGLNEE--------------IARVELECETIKQENTRLQNIID 357
+ NL A LD+ + L +E + E + T+ + +L+ +D
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD 1032
Query: 358 NQKYSV-------ADIER----INHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKE 406
+ + S+ D+ER + + Q++I L D + ++L ++ +
Sbjct: 1033 DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNA 1092
Query: 407 AIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV-KYRAQVYVPLKELL 465
IE + A +L +KLK + E + E + E A V K R+ + L+E+
Sbjct: 1093 RIEDEQALGSQLQKKLKELQARIE-----ELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Query: 466 NETEE-----EINKALNKK---------MGLEDTLEQLNAMITESKR----SVRTLKEEV 507
EE + +NKK LE+ Q A ++ SV L E++
Sbjct: 1148 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1207
Query: 508 QKLDDLYQQKIKEAEE---EDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREY 564
L + Q+ KE E E + S +E + K K LE + + L + MNE + E
Sbjct: 1208 DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK-MCRTLEDQMNEHRSKAEET 1266
Query: 565 QLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDR 609
Q V T +R K + T G + + L+E+ A + +
Sbjct: 1267 QRSVNDLTSQRAK-----------LQTENGELSRQLDEKEALISQ 1300
Score = 35.4 bits (80), Expect = 0.16
Identities = 38/188 (20%), Positives = 84/188 (44%), Gaps = 11/188 (5%)
Query: 454 RAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL 513
R + +KE +E + K+ ++ LE+ + L + + V+ ++ + ++
Sbjct: 845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEER 904
Query: 514 YQQKIKEAEEEDEKCASELESLEKHKHL-LESTV-NQGLSEAMNELDAVQREYQLVVQTT 571
Q IK + + K E LE + + E T + L + +EL + +L +
Sbjct: 905 CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Query: 572 TEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYE 631
+E+ N ++ L E +A L+E IAK+ +E ++ + E + + +++ + +
Sbjct: 965 EKEKHATENKVKNLTEEMA--------GLDEIIAKLTKE-KKALQEAHQQALDDLQAEED 1015
Query: 632 KKATLIKS 639
K TL K+
Sbjct: 1016 KVNTLTKA 1023
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 73.9 bits (180), Expect = 4e-13
Identities = 89/422 (21%), Positives = 184/422 (43%), Gaps = 59/422 (13%)
Query: 248 AELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDV 307
AE++ KLK+ K + L+ K +Q+ +++E + ++ + LK L+
Sbjct: 1123 AEVEEKLKE-------KSQQLQEKQ----QQLLNVQEEMSEMQKKINEIENLKNELKNK- 1170
Query: 308 QKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIE 367
+ + ++E+ L QKLN EE+ + E + +K+ + D+ + + +IE
Sbjct: 1171 ---ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
Query: 368 ----------RINH-ERNELQQTINKLTKDLEAEQQKLWNE---ELKYARGKEAIETQLA 413
+I H E Q+TI++L + + + ++ N E + + +E I L
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV-LH 1286
Query: 414 EYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEIN 473
E +L +K + + E + + + + L + + + L E E++EEI
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME-RLRLNEKFQESQEEIK 1345
Query: 474 KALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKI--KEAEEEDEKCASE 531
++ L+ E L + K +R ++Q+ +Q + KE + E K SE
Sbjct: 1346 SLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSE 1405
Query: 532 LESLE-KHKHLLESTV-----NQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRL 585
+E + K LL + ++ L E+ +E+ +V +E ++LQRL
Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE---------------KDDLQRL 1450
Query: 586 LEMVATHVGSVEKHLEEQIAKVDREYEE-----CMSEDLSENIKEIRDKYEKKATLIKSS 640
E++ + ++++++E +AK EE C ++ E I E+R +K T I +
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 641 EE 642
++
Sbjct: 1511 QK 1512
Score = 69.3 bits (168), Expect = 1e-11
Identities = 83/402 (20%), Positives = 175/402 (43%), Gaps = 43/402 (10%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASL 303
+ MN E+ + K+ D+ SL A L+ + L+++ + RL + +LK L
Sbjct: 841 ERMNQEIVNLSKEAQKFDS----SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896
Query: 304 QGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSV 363
+ + + +E ++ +KL EE+ + E + +KQ LQ D K +
Sbjct: 897 ENR----DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI 952
Query: 364 ADIERINHE-----RNEL------QQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL 412
D +N + RN L Q+TIN L + E + + E K+ + ++
Sbjct: 953 HDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012
Query: 413 AEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEI 472
K K L A+N++ ++K N +++ + +++ ++E NE ++ +
Sbjct: 1013 VGIDK---KQDL---EAKNTQTLTADVKDNE------IIEQQRKIFSLIQE-KNELQQML 1059
Query: 473 NKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASEL 532
+ +K L+ L++ M E++ +R L +E++K ++ Q+ A +++ + +
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
Query: 533 ESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVG--NNLQRLLEMVA 590
+ L + V + L E +L Q++ V + +E ++K+ NL+ L+
Sbjct: 1120 DRL--------AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKE 1171
Query: 591 THVGSVEKHLEEQIAKVDREYEECMSEDLSENI-KEIRDKYE 631
+ +E E K++ YEE S + KE++ +E
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFE 1213
Score = 65.1 bits (157), Expect = 2e-10
Identities = 93/460 (20%), Positives = 201/460 (43%), Gaps = 68/460 (14%)
Query: 232 CYES--FMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAK--NRALNEQIARLEQE-- 285
C ES F + D+ E+ +KL + N+++ +L SL A N L+ + R E+E
Sbjct: 466 CSESDVFSNTLDTLSEIEWNPATKLLNQENIES-ELNSLRADYDNLVLDYEQLRTEKEEM 524
Query: 286 --REKEPNRLESLRKLKASLQGDVQKYQAY----MSNLESHSAILDQKLNGLNEEIARVE 339
+ KE N L+ L+ + D + + + NL H+ + +Q L NE ++VE
Sbjct: 525 ELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE--NELSSKVE 582
Query: 340 LECETIKQENTRLQNIIDNQK---------YSVADIERINHERNELQQTI---NKLTKDL 387
L E + + +LQ ID+QK YS+ IE + +++QT+ + D
Sbjct: 583 LLREK-EDQIKKLQEYIDSQKLENIKMDLSYSLESIE----DPKQMKQTLFDAETVALDA 637
Query: 388 EAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGA 447
+ E L +E L+ KE ++ Y ++ ++L E K +++ ++
Sbjct: 638 KRESAFLRSENLEL---KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAF 694
Query: 448 N------------------CLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQL 489
N C ++ ++ KEL E EE N+AL +++ L L+ L
Sbjct: 695 NEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEE--NEALREEVILLSELKSL 752
Query: 490 NAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVN-- 547
+ + ++ ++ EE+ + + E ++ + LE + K K L +T +
Sbjct: 753 PSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 548 QGLSEAMNELDAVQREYQLVVQTTTEERRKVGN---NLQRLLEMVATHVGSVEKHLE--- 601
+ + + +++ + EE ++ NL + + + +G+++ L
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 602 EQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSE 641
+++ + RE +E ++E +++++++ E + + +++ E
Sbjct: 873 QELQEKTREVQERLNE-----MEQLKEQLENRDSTLQTVE 907
Score = 56.2 bits (134), Expect = 9e-08
Identities = 82/408 (20%), Positives = 174/408 (42%), Gaps = 51/408 (12%)
Query: 241 DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK 300
++ D++ + K ++ N+ + LE N AL Q ++++E L+ ++
Sbjct: 1735 ETIDKLRGIVSEKTNEISNMQ----KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
L+G V + +SN++ + KL +E+ E + T+K+
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK------------- 1837
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
D+ + +E++Q + K KD KL E L A+ + H+
Sbjct: 1838 ----DVNETQKKVSEMEQ-LKKQIKDQSLTLSKLEIENLNLAQ----------KLHENLE 1882
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM 480
++K + K +N + + +K + L + +A+ E ++E+ A
Sbjct: 1883 EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL--------EIQQELKTARMLSK 1934
Query: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLE-KHK 539
++T+++L I+E + +++++ K D Q+KI+E ++++ + E + HK
Sbjct: 1935 EHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994
Query: 540 HLLESTVNQGLSEAMN-ELDAVQRE-YQLV--VQTTTEERR---KVGNNLQRLLEMVATH 592
+ E + EA N + +V+ + +QL + + EE R K + L+R+ E +
Sbjct: 1995 KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKME 2054
Query: 593 VGSVEKHLEEQIAKVDREYEECMSED--LSENIKEIRDKYEKKATLIK 638
L E IA+ DR+ + E LS+ + + + +K + IK
Sbjct: 2055 RDQFIATLREMIAR-DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIK 2101
Score = 49.7 bits (117), Expect = 8e-06
Identities = 87/425 (20%), Positives = 181/425 (42%), Gaps = 67/425 (15%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASL 303
+ +N +LQ+K+++++ K E K QI+ + QE+ E + + RK K S
Sbjct: 1515 EAINDKLQNKIQEIYE----KEEQFNIK------QISEV-QEKVNELKQFKEHRKAKDSA 1563
Query: 304 QGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSV 363
+ ++ES L +L EEI + E E +K+ LQ D K +
Sbjct: 1564 ----------LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT 1613
Query: 364 ADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKL----A 419
+I E E + K+T E +++ E L KE ETQ +
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL-----KEQFETQKLNLENIETENI 1668
Query: 420 RKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLN---ETEEEINKAL 476
R +++ + E + E + + + L R Q+ L+E + E +EE+
Sbjct: 1669 RLTQILHENLEEMRSVTKE-RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVH 1727
Query: 477 NKKMGLEDTLEQLNAMITESKRSVRTLKEEVQ------KLDDLYQQK--------IKEAE 522
++T+++L +++E + ++++++ K DL Q+ +KE +
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787
Query: 523 EEDEK----CASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKV 578
E +K + + + L + LE++ N L E + EL A + + + + E ++KV
Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQKDLENS-NAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846
Query: 579 GNNLQRLLEMVATHVGSVEKHLEEQIAKVDR-EYEEC-MSEDLSENIKEIRDKYEKKATL 636
+ + ++K +++Q + + E E +++ L EN++E++ +++ L
Sbjct: 1847 ------------SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894
Query: 637 IKSSE 641
+ E
Sbjct: 1895 RRVEE 1899
Score = 49.3 bits (116), Expect = 1e-05
Identities = 90/388 (23%), Positives = 172/388 (44%), Gaps = 65/388 (16%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQ 304
E +L + KDL N +A KL+ + +A Q+ L+++ + ++ + +LK ++
Sbjct: 1799 EKTDKLSNMQKDLENSNA-KLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIK 1857
Query: 305 GDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVA 364
+S LE + L QKL+ EE+ V E + +++
Sbjct: 1858 DQ----SLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE--------------- 1898
Query: 365 DIERINHERNELQQTINKL-TKDLEAEQQKLWNEELKYAR--GKEAIETQLAEYHKLARK 421
E + ER++L++++ + +DLE +Q ELK AR KE ET K++ K
Sbjct: 1899 --ETLKLERDQLKESLQETKARDLEIQQ------ELKTARMLSKEHKETVDKLREKISEK 1950
Query: 422 ---LKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNK 478
+ I K + SK + + K L K Q+ + +KE +N + ++IN+
Sbjct: 1951 TIQISDIQKDLDKSKD-ELQKKIQE------LQKKELQL-LRVKEDVNMSHKKINE---- 1998
Query: 479 KMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKH 538
+EQL S+++++ + +L +K+ E+ EE A E + L +
Sbjct: 1999 -------MEQLKKQFEAQNLSMQSVRMDNFQL----TKKLHESLEEIRIVAKERDELRRI 2047
Query: 539 KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK 598
K L+ +Q ++ + E+ A R+ V E+R + + Q L E + + K
Sbjct: 2048 KESLKMERDQFIA-TLREMIARDRQNHQV----KPEKRLLSDGQQHLTESLREKCSRI-K 2101
Query: 599 HLEEQIAKVDREYE--ECMSEDLSENIK 624
L ++ +++D YE +S DL + I+
Sbjct: 2102 ELLKRYSEMDDHYECLNRLSLDLEKEIE 2129
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 73.2 bits (178), Expect = 7e-13
Identities = 98/416 (23%), Positives = 176/416 (42%), Gaps = 58/416 (13%)
Query: 251 QSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKY 310
Q L DL V+ K+ SL L +Q+ LE E+E L + K L+GD++
Sbjct: 1006 QQALDDL-QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1064
Query: 311 QAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
Q + +LE+ L++KL +I + + E + +LQ + + + ++E
Sbjct: 1065 QESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL 1124
Query: 371 HERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL-----AEYHKLARKLKLI 425
+ + KL DL E +++ +E L+ A G +++ ++ AE+ K+ R L+
Sbjct: 1125 EAERTARAKVEKLRSDLSRELEEI-SERLEEAGGATSVQIEMNKKREAEFQKMRRDLE-- 1181
Query: 426 PKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNK-----KM 480
E EA A L K A L E ++ + + + L K K+
Sbjct: 1182 ------------EATLQHEATAAALRKKHADSVAELGEQIDNL-QRVKQKLEKEKSEFKL 1228
Query: 481 GLED-------------TLEQLNAMITESKRSVRTLKEEVQK-LDDLYQQKIKEAEEEDE 526
L+D LE+++ + + R EE Q+ L+D Q+ K + E+
Sbjct: 1229 ELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAK-LQTENG 1287
Query: 527 KCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLL 586
+ A +LE K L S + +G +++ ++R+ EE K N L L
Sbjct: 1288 ELARQLE----EKEALISQLTRGKLSYTQQMEDLKRQ--------LEEEGKAKNALAHAL 1335
Query: 587 EMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
+ A H + + E+ + E + +S+ SE + + R KYE A I+ +EE
Sbjct: 1336 QS-ARHDCDLLREQYEEETEAKAELQRVLSKANSE-VAQWRTKYETDA--IQRTEE 1387
Score = 68.2 bits (165), Expect = 2e-11
Identities = 88/434 (20%), Positives = 183/434 (42%), Gaps = 65/434 (14%)
Query: 234 ESFMSGADSFDEMNAELQSKLKDLFNVDAFKLES----LEAKNRALNEQIARLEQEREKE 289
E+ + S ++ LQ++++DL VD + + L+ K R ++ +A +Q+ E+
Sbjct: 1407 EAVNAKCSSLEKTKHRLQNEIEDLM-VDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1465
Query: 290 PNRLESLRKLKASLQGDVQKYQ-AYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE 348
+ LES +K SL ++ K + AY +LE ET K+E
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLE----------------------HLETFKRE 1503
Query: 349 NTRLQNIIDNQK-------YSVADIERINH----ERNELQQTINKLTKDLEAEQQKLWNE 397
N LQ I + +V ++E++ E+ ELQ + + LE E+ K+
Sbjct: 1504 NKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRA 1563
Query: 398 ELKYARGKEAIETQLAE-----------YHKLARKLKLIPKGAENSKGYDFEIKFNPE-- 444
+L++ + K IE +LAE + ++ L+ S+ +K E
Sbjct: 1564 QLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGD 1623
Query: 445 --------AGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTL---EQLNAMI 493
+ AN + + L+ LL +T+ +++ A+ L++ + E+ N ++
Sbjct: 1624 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683
Query: 494 TESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEA 553
+R + E+ ++ L +Q++ E E + S+ SL K +ES + Q SE
Sbjct: 1684 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV 1743
Query: 554 MNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEE 613
+ + + + T + + L++ + + H+ ++K++E+ I + +E
Sbjct: 1744 EEAVQECRNAEEKAKKAIT-DAAMMAEELKKEQD-TSAHLERMKKNMEQTIKDLQHRLDE 1801
Query: 614 CMSEDLSENIKEIR 627
L K+++
Sbjct: 1802 AEQIALKGGKKQLQ 1815
Score = 57.8 bits (138), Expect = 3e-08
Identities = 90/425 (21%), Positives = 171/425 (40%), Gaps = 57/425 (13%)
Query: 254 LKDLFNVDAFKLESLEAKNRALNEQIARLEQER--------------EKEPNRLESLRKL 299
+K+ F LE EA+ + L E++ L QE+ R + L K
Sbjct: 854 MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKN 913
Query: 300 KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE-------IARVELECETIKQENTRL 352
K L+ V++ + + E +A L K L +E I +EL +++E
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 353 QNIIDNQKYSVADIE----RINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAI 408
+N + N +A ++ ++ E+ LQ+ + DL+ E+ K+ ++ K +
Sbjct: 974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKV----NSLSKSKVKL 1029
Query: 409 ETQLAEYHKLARKLKLIPKGAENSK-GYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNE 467
E Q+ + + K + E +K + ++K E+ + + L+E L +
Sbjct: 1030 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES-----IMDLENDKLQLEEKLKK 1084
Query: 468 TEEEINKALNKKMGLEDTLE-QLNAMITESKRSVRTLKEEVQ-------KLDDLYQQKIK 519
E +IN+ N K+ E L QL + E++ + L+EE++ K++ L +
Sbjct: 1085 KEFDINQQ-NSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSR 1143
Query: 520 EAEEEDEK------CASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTE 573
E EE E+ S + K + + + L EA + +A + +
Sbjct: 1144 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1203
Query: 574 ERRKVGNNLQRLLEMVATHVGSVEKHLE------EQIAKVDREYEECMSEDLSENIKEIR 627
E + +NLQR+ + + + L+ EQI K E+ +S L + E R
Sbjct: 1204 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK-VSRTLEDQANEYR 1262
Query: 628 DKYEK 632
K E+
Sbjct: 1263 VKLEE 1267
Score = 55.1 bits (131), Expect = 2e-07
Identities = 81/409 (19%), Positives = 168/409 (41%), Gaps = 32/409 (7%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLE---SLEAKNRALNEQIARLEQEREKEPNRLESLRKLK 300
+E+ EL+++ V+ + + LE + L E + E R +K++
Sbjct: 1118 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMR 1177
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE-NTRLQNIIDNQ 359
L+ +++A + L A +L + + RV+ + E K E L ++ N
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1237
Query: 360 KYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEY-HKL 418
+ + + L+ N+ LE Q+ L + + A+ ++T+ E +L
Sbjct: 1238 EQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAK----LQTENGELARQL 1293
Query: 419 ARKLKLIPKGAENSKGY-----DFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEIN 473
K LI + Y D + + E A + + Q +LL E EE
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET 1353
Query: 474 KALNKKMGLEDTLEQLNAMITESKRSVRT----LKEEVQKLDDLYQQKIKEAEEEDEKCA 529
+A K L+ L + N+ + + + T EE+++ Q++++AEE E
Sbjct: 1354 EA---KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410
Query: 530 SELESLEKHKHLLESTVN------QGLSEAMNELDAVQREYQLVV---QTTTEERRKVGN 580
++ SLEK KH L++ + + + A LD QR + ++ + EE +
Sbjct: 1411 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1470
Query: 581 NLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDK 629
+ Q+ ++T + ++ EE + ++ E +++L E I ++ ++
Sbjct: 1471 SSQKEARSLSTELFKLKNAYEESLEHLETFKRE--NKNLQEEISDLTEQ 1517
Score = 54.7 bits (130), Expect = 3e-07
Identities = 79/403 (19%), Positives = 179/403 (44%), Gaps = 58/403 (14%)
Query: 243 FDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKAS 302
F+++ AE++ KL + K E +E R + L+ + E + ++K
Sbjct: 1567 FNQIKAEIERKLAE-------KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKK 1619
Query: 303 LQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYS 362
++GD+ + + +S+ +A +++ L + +++ + + N D+ K +
Sbjct: 1620 MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN-------DDLKEN 1672
Query: 363 VADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKL 422
+A +ER N N LQ + +L +E + R ++ E +L E + + L
Sbjct: 1673 IAIVERRN---NLLQAELEELRAVVEQTE-----------RSRKLAEQELIETSERVQLL 1718
Query: 423 KLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGL 482
++N+ + + K + L + +++V ++E N EE+ KA+ +
Sbjct: 1719 H-----SQNTSLINQKKKMESD-----LTQLQSEVEEAVQECRN-AEEKAKKAITDAAMM 1767
Query: 483 EDTLEQ---LNAMITESKRSV-RTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKH 538
+ L++ +A + K+++ +T+K+ +LD+ Q +K +++ +K + + LE
Sbjct: 1768 AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGE 1827
Query: 539 KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK 598
LE+ + + +R +L Q TEE +K LQ L++ + V + ++
Sbjct: 1828 ---LEAEQKRNAESVKGMRKSERRIKELTYQ--TEEDKKNLLRLQDLVDKLQLKVKAYKR 1882
Query: 599 HLEEQIAKVDREYEECMSEDLSE--NIKEIRDKYEKKATLIKS 639
EE EE + +LS+ ++ D+ E++A + +S
Sbjct: 1883 QAEEA--------EEQANTNLSKFRKVQHELDEAEERADIAES 1917
Score = 52.0 bits (123), Expect = 2e-06
Identities = 102/470 (21%), Positives = 185/470 (39%), Gaps = 79/470 (16%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGA----DSFDEMNAELQSKLKDLFNVDAFKLESL 268
EE ++ K L ++ + ++ A D + +L++K+K++ +LE
Sbjct: 876 EEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNE----RLEDE 931
Query: 269 EAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKL 328
E N L + +LE E + ++ L A ++ + + + NL A LD+ +
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Query: 329 NGLNEE---------IARVELECE------------TIKQENTRLQNIIDNQKYSVADIE 367
L +E A +L+ E ++Q+ L+ ++ +K D+E
Sbjct: 992 AKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLE 1051
Query: 368 R----INHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLK 423
R + + Q++I L D ++KL +E + IE + +L +KLK
Sbjct: 1052 RAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111
Query: 424 LIPKGAENSKGYDFEIKFNPEAGANCLV-KYRAQVYVPLKELLNETEE-----EINKALN 477
++ + E + E A V K R+ + L+E+ EE + +N
Sbjct: 1112 -----ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1166
Query: 478 KK---------MGLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDLYQQKIKEAEE- 523
KK LE+ Q A ++ SV L E++ L + Q+ KE E
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226
Query: 524 --EDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNN 581
E + S +E + K K LE V++ L + NE E Q + T +R K
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAK---- 1281
Query: 582 LQRLLEMVATHVGSVEKHLEEQIAKVDR------EYEECMSEDLSENIKE 625
+ T G + + LEE+ A + + Y + M EDL ++E
Sbjct: 1282 -------LQTENGELARQLEEKEALISQLTRGKLSYTQQM-EDLKRQLEE 1323
Score = 38.5 bits (88), Expect = 0.019
Identities = 51/206 (24%), Positives = 96/206 (46%), Gaps = 35/206 (16%)
Query: 456 QVYVPLKELLN--ETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL 513
++Y +K LL ETE+E+ + +++TLE+ A E + + +L +E L
Sbjct: 833 KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892
Query: 514 YQQKIKEAEEEDEKCASELESLEKHKHLLESTV---NQGL--SEAMN-ELDAVQR----- 562
Q + + +E+C + L K+K LE+ V N+ L E MN EL A +R
Sbjct: 893 VQAEQDNLNDAEERC----DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 563 ---------EYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEE 613
+ +L + +E+ N ++ L E +A L+E IAK+ +E ++
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA--------GLDEIIAKLTKE-KK 999
Query: 614 CMSEDLSENIKEIRDKYEKKATLIKS 639
+ E + + +++ + +K +L KS
Sbjct: 1000 ALQEAHQQALDDLQVEEDKVNSLSKS 1025
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 72.8 bits (177), Expect = 9e-13
Identities = 97/408 (23%), Positives = 168/408 (41%), Gaps = 42/408 (10%)
Query: 251 QSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKY 310
Q L DL + K+ SL L +Q+ LE E+E L + K L+GD++
Sbjct: 1005 QQALDDL-QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLA 1063
Query: 311 QAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
Q + +LE+ LD++L + E +++ + E + + Q I + + ++E
Sbjct: 1064 QESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI 1123
Query: 371 HERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL-----AEYHKLARKLKLI 425
+ K D E ++L +E L+ A G + + +L AE+ KL R L+
Sbjct: 1124 EAERATRAKTEKQRSDYARELEEL-SERLEEAGGVTSTQIELNKKREAEFLKLRRDLE-- 1180
Query: 426 PKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDT 485
E EA L K A L E ++ + K +K +
Sbjct: 1181 ------------EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1228
Query: 486 LEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLEST 545
++ L++ S SV K ++K+ + ++ EA ++E+ L L K L++
Sbjct: 1229 IDDLSS----SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE 1284
Query: 546 VNQGLSEAMNELDAV----QREYQLVVQTT------TEERRKVGNNLQRLLEMVATHVGS 595
+ LS + E +++ R Q Q T EE K N L L+
Sbjct: 1285 AGE-LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343
Query: 596 V-EKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
+ E++ EEQ K E + +S+ SE + + R KYE A I+ +EE
Sbjct: 1344 LREQYEEEQEGKA--ELQRALSKANSE-VAQWRTKYETDA--IQRTEE 1386
Score = 70.1 bits (170), Expect = 6e-12
Identities = 93/418 (22%), Positives = 179/418 (42%), Gaps = 41/418 (9%)
Query: 242 SFDEMNAELQSKLKDLFNVDAF-KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK 300
+ + N+E+ ++ + + DA + E LE + L +++ E++ E + SL K K
Sbjct: 1361 ALSKANSEV-AQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE-----------N 349
LQG+V+ + S +A LD+K ++ +A + +CE + E +
Sbjct: 1420 QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLS 1479
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNE--------ELKY 401
T L + + + ++ +E + E L+Q I LT+ + AE K +E EL+
Sbjct: 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI-AENGKTIHELEKSRKQIELEK 1538
Query: 402 ARGKEAI-ETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVP 460
A + A+ E + A H+ A+ L++ + + D +I E Y+ V
Sbjct: 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVET- 1597
Query: 461 LKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKR-SVRTLK--EEVQKLDDLYQQK 517
++ L+ N+A+ K +E L ++ ++ + R + TLK VQ Q
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 518 IKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRK 577
+ +A E +L +E+ +LL++ V E L+ +R +L Q + +
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLLQAEV----EELRATLEQTERARKLAEQELLDSNER 1713
Query: 578 VGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKAT 635
V +LL T + +K LE + ++ E ED S + + +K +K T
Sbjct: 1714 V-----QLLHTQNTSLIHTKKKLETDLMQLQSEV-----EDASRDARNAEEKAKKAIT 1761
Score = 65.5 bits (158), Expect = 1e-10
Identities = 101/462 (21%), Positives = 195/462 (42%), Gaps = 82/462 (17%)
Query: 200 ESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFN 259
ES L D EE D ++ K L+ IK A+ +E+NAEL +K + L +
Sbjct: 895 ESENLLD-----AEERCDQLIKAKFQLEAKIK---EVTERAEDEEEINAELTAKKRKLED 946
Query: 260 --------VDAFKL---------ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKAS 302
+D +L + E K + L E+++ L+ E++ KL
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD----------ETIAKLTRE 996
Query: 303 LQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYS 362
+ + +Q + +L++ + K+N LN+ +++E + E L++ ++ +K
Sbjct: 997 KKALQEAHQQALDDLQAE----EDKVNSLNKTKSKLEQQVED-------LESSLEQEKKL 1045
Query: 363 VADIER----INHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKL 418
D+ER + + Q++I L D + ++L ++ +Y + + +E + +
Sbjct: 1046 RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQF 1105
Query: 419 ARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV-KYRAQVYVPLKELLNETEE------- 470
+K+K + E + E + E K R+ L+EL EE
Sbjct: 1106 QKKIKELQARIE-----ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST 1160
Query: 471 --EINKA-----LNKKMGLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDLYQQKIK 519
E+NK L + LE+ Q AM+ ++ SV L E++ L + Q+ K
Sbjct: 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 520 EAEE---EDEKCASELESLEKHKHLLES---TVNQGLSEAMNELDAVQREYQLVVQTTTE 573
E E E + +S +ES+ K K LE T+ LSEA + + +QR + +
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 574 ERRKVGNNLQRL--LEMVATHVGSVEKHLEEQIAKVDREYEE 613
+ + G ++L E + + + ++ +Q ++ R+ EE
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Score = 56.6 bits (135), Expect = 7e-08
Identities = 104/432 (24%), Positives = 189/432 (43%), Gaps = 75/432 (17%)
Query: 254 LKDLFNVDAFKLESLEAKNRALNEQIARLEQER---------EKE-----PNRLESLRKL 299
+K+ F +L EAK + L E++ L QE+ E E R + L K
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 300 KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE-------IARVELECETIKQENTRL 352
K L+ +++ + E +A L K L +E I +EL +++E
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 353 QNIIDN--QKYSVAD--IERINHERNELQQTINKLTKDLEAEQQK---LWNEELKYARGK 405
+N + N ++ S D I ++ E+ LQ+ + DL+AE+ K L + K +
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 406 EAIETQLAEYHKL-------ARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVY 458
E +E+ L + KL RKL+ K A+ S D E N + + +K + Y
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI-LDLE---NDKQQLDERLKKKDFEY 1088
Query: 459 VPLKELLNETEEEINKALNKKM-GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQK 517
L+ + E E+ + KK+ L+ +E+L I E++R+ R K E Q+ D Y ++
Sbjct: 1089 CQLQSKV-EDEQTLGLQFQKKIKELQARIEELEEEI-EAERATRA-KTEKQRSD--YARE 1143
Query: 518 IKEAEEEDEKCAS------------ELESLEKHKHLLESTVN-------------QGLSE 552
++E E E+ E E L+ + L E+T+ ++E
Sbjct: 1144 LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203
Query: 553 AMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK---HLEEQIAKVDR 609
++D +QR Q + + +E + ++ ++L +E V+ ++EK LE+Q+++
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEI-DDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262
Query: 610 EYEECMSEDLSE 621
+ EE + LSE
Sbjct: 1263 KNEE-IQRSLSE 1273
Score = 54.3 bits (129), Expect = 3e-07
Identities = 74/342 (21%), Positives = 151/342 (44%), Gaps = 37/342 (10%)
Query: 267 SLEAKNRALNEQIARLEQEREKEPNRLE------------SLRKLKASLQGDVQKYQAYM 314
+L+A+ R+ NE I RL+++ E + N +E +L+ L+ S+QG ++ Q ++
Sbjct: 1601 ALDAEVRSRNEAI-RLKKKMEGDLNEIEIQLSHANRQAAETLKHLR-SVQGQLKDTQLHL 1658
Query: 315 SN-------LESHSAILDQKLNGLNEEIARVELECE-TIKQENTRLQNIID-NQKYSVAD 365
+ L+ AI++++ N L E+ + E T + Q ++D N++ +
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718
Query: 366 IERIN--HERNELQQTINKLTKDLEAEQQKLWNEELKYARG---KEAIETQLAEYHKLAR 420
+ + H + +L+ + +L ++E + N E K + + +L + +
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSA 1778
Query: 421 KLKLIPKGAENS-KGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKK 479
L+ + K E + K + + K ++ ++EL E E E K
Sbjct: 1779 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESV 1838
Query: 480 MGL---EDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLE 536
GL E +++L E +++V L++ V KL + ++AEE DE+ + L
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR 1898
Query: 537 KHKHLLESTVNQG--LSEAMNELDAVQREY---QLVVQTTTE 573
K +H LE + +N+L A R++ ++VV + E
Sbjct: 1899 KAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 37.4 bits (85), Expect = 0.043
Identities = 39/184 (21%), Positives = 84/184 (45%), Gaps = 11/184 (5%)
Query: 461 LKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKE 520
+KE +T++E+ K+ K+ LE+ L L + + V+ E + ++ Q IK
Sbjct: 853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 521 AEEEDEKCASELESLEKHKHL-LESTV-NQGLSEAMNELDAVQREYQLVVQTTTEERRKV 578
+ + K E E + + E T + L + +EL + +L + +E+
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 579 GNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIK 638
N ++ L E ++ L+E IAK+ RE ++ + E + + +++ + +K +L K
Sbjct: 973 ENKVKNLTEELS--------GLDETIAKLTRE-KKALQEAHQQALDDLQAEEDKVNSLNK 1023
Query: 639 SSEE 642
+ +
Sbjct: 1024 TKSK 1027
Score = 34.7 bits (78), Expect = 0.28
Identities = 40/165 (24%), Positives = 78/165 (47%), Gaps = 24/165 (14%)
Query: 495 ESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAM 554
E+++ + T+KEE QK D ++ ++E + ++ +L +L + K+ L+ V +E+
Sbjct: 845 ETEKEMATMKEEFQKTKD----ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ---AESE 897
Query: 555 NELDAVQREYQLV------------VQTTTEERRKVGNNL---QRLLEMVATHVGSVEKH 599
N LDA +R QL+ V E+ ++ L +R LE + +
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 600 LEEQIAKVDREYE--ECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
LE +AKV++E E ++L+E + + + K K+ +E
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE 1002
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 72.8 bits (177), Expect = 9e-13
Identities = 94/425 (22%), Positives = 187/425 (44%), Gaps = 58/425 (13%)
Query: 251 QSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKY 310
+ KLK DA + LE KN + E++ L + ++ E E++RKL+ +Q ++
Sbjct: 270 EEKLKLQQKHDADVQKILERKNNEI-EELKTLYRSKQHETE--ETIRKLEKKVQTLIRDC 326
Query: 311 QAYMSNLESHSA----ILDQKLNGLNEEIAR------VELECETIKQENTRLQNIIDNQK 360
Q E A I +Q LN + + E+E E + +NI + +
Sbjct: 327 QVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLE 386
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
+ + ++ E Q+ N + K+LEA Q+L E AE L R
Sbjct: 387 DTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGE---------------AENSNLQR 431
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM 480
+ KLI + AE + Y E A R ++ L+N+ E+ + K L K
Sbjct: 432 Q-KLIQEKAELERCYQITCSELQEVKAR-----RNTLHKEKDHLVNDYEQNM-KLLQTKY 484
Query: 481 GLEDTL---------EQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASE 531
+ L + ++MI E +++V LK+++Q+ + +Q++++ E + + S
Sbjct: 485 DADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSH 544
Query: 532 LESL-EKHKHLLESTVNQGLSEAMNEL----DAVQREYQLVVQTTTEER---RKVGNNLQ 583
L+ + EK H L+S +++G + ++ +A++ + + + + T +R ++ L+
Sbjct: 545 LKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALE 604
Query: 584 RLLEMVATHVGSVEKHLEEQIAKVD------REYEECMSEDLSENIKEIRDKYEKKATLI 637
V + V ++EQ+ KV+ + E S++ +++IR +YE++ +
Sbjct: 605 EFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVEL 664
Query: 638 KSSEE 642
K E
Sbjct: 665 KLEHE 669
Score = 45.1 bits (105), Expect = 2e-04
Identities = 65/325 (20%), Positives = 135/325 (41%), Gaps = 31/325 (9%)
Query: 245 EMNAE-LQSKLKD-LFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKAS 302
E+N+E + +++K+ + V+A S + + E + +LE R++ ++ L+
Sbjct: 611 ELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELK----- 665
Query: 303 LQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQEN-TRLQNIIDNQKY 361
++ Q L+ H+A D + EI +E + E+ ++Q
Sbjct: 666 ----LEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQ 721
Query: 362 SVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARK 421
+AD+E H+ E +N K E L EE + A E+ + K
Sbjct: 722 VIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRAT---------REHEIVVNK 772
Query: 422 LKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMG 481
LK AE+ K E+K A ++ + LK++ E +++ K+
Sbjct: 773 LK-----AESEK-MKIELKKTHAAETEMTLE---KANSKLKQIEKEYTQKLAKSSQIIAE 823
Query: 482 LEDTLEQLNAMITESKRSV-RTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKH 540
L+ T+ L ++ + + R L++ QK +D +Q I++ ++ + ELE+
Sbjct: 824 LQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVR 883
Query: 541 LLESTVNQGLSEAMNELDAVQREYQ 565
E + E+ ++ +++EY+
Sbjct: 884 CAEKKLQHKELESQEQITYIRQEYE 908
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 72.4 bits (176), Expect = 1e-12
Identities = 94/433 (21%), Positives = 187/433 (43%), Gaps = 64/433 (14%)
Query: 242 SFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALN-EQIARLEQEREKEPNRLESLRKLK 300
S +E+ Q +L+ N D K+ ++E + ++ E++ +L +E E L+ + K
Sbjct: 386 SLEELLRTEQQRLEK--NEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEK 443
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETI-------KQENTRLQ 353
+L + ++++ L+ L L +E+ +E++ I +E L+
Sbjct: 444 ETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLK 503
Query: 354 NIIDNQKYSVADI----ERINHERNELQQTINKLTKDLEAEQQKLWNEE------LKYAR 403
++N+K ++ +++ E EL Q + +T +L+ +Q+ + N + LK
Sbjct: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
Query: 404 GKEAIETQLAEYHKLAR----------KLKL---------IPKGAENSKGYDFEIKFNPE 444
+ ETQL + R K KL + K EN Y E++ +
Sbjct: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623
Query: 445 AGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLK 504
A Q+ V + +N+ E E+ A K + DT ++ I + K S L
Sbjct: 624 ALKKKGTAESKQLNV-YEIKVNKLELELESAKQKFGEITDTYQK---EIEDKKISEENLL 679
Query: 505 EEVQKLDDLYQQKIKEAEEEDEKC----ASELESLEKHKHLLESTVNQGLSEAMNELDAV 560
EEV+K + + +K +E D++C A + +EKHKH + + + SE
Sbjct: 680 EEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELG------ 733
Query: 561 QREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLS 620
+ ++ +E+ + +L+ L + + SV+K LE ++RE +E + +
Sbjct: 734 ------LYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLE-----IEREEKEKLKREAK 782
Query: 621 ENIKEIRDKYEKK 633
EN +++K +KK
Sbjct: 783 ENTATLKEKKDKK 795
Score = 55.1 bits (131), Expect = 2e-07
Identities = 97/467 (20%), Positives = 187/467 (40%), Gaps = 73/467 (15%)
Query: 220 MHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQI 279
MH KL DY + + E + ++ D + L + K + +
Sbjct: 239 MHFKLKEDY------------EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
Query: 280 ARLEQEREKEPNRLESLRKLKA-SLQGDVQKYQAYMSNLE----------SHSAILDQKL 328
LE+ R+K N+LE KL++ +L+ ++K LE S L++ L
Sbjct: 287 FLLEESRDK-VNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDL 345
Query: 329 NGLNEEIARVELECETIKQENTRLQN----IIDNQKYSVADIERI------NHERNE--- 375
+ I ++ E ET +E+ + + ++ + +V +E + E+NE
Sbjct: 346 QIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQL 405
Query: 376 --LQQTINKLTKDLEAEQQKLWN------EELKYARG-KEAIETQLAEYHKLARKLKLIP 426
L + K + +LE E KL N EELK G KE + + ++ K+A +LK
Sbjct: 406 KILTMELQKKSSELE-EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTE 464
Query: 427 K------GAENSKGYDFEIKFNPEAGANCLVKYRAQVY-VPLKELLNETEEEINKALNKK 479
+ A + +D EI+ + Q Y +K+L E E N+K
Sbjct: 465 QELIGLLQAREKEVHDLEIQLT-------AITTSEQYYSKEVKDLKTELE-------NEK 510
Query: 480 MGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHK 539
+ + N + E+K + + +L + Q+ I ++++E+ ++E+L++ +
Sbjct: 511 LKNTELTSHCNKLSLENKELTQETSDMTLELKN-QQEDINNNKKQEERMLKQIENLQETE 569
Query: 540 HLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKH 599
L + + E + D V+ + + R++V N + + E+ + +K
Sbjct: 570 TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKG 629
Query: 600 LEE----QIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
E + ++ E E + EI D Y+K+ K SEE
Sbjct: 630 TAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEE 676
Score = 53.9 bits (128), Expect = 4e-07
Identities = 74/396 (18%), Positives = 181/396 (45%), Gaps = 56/396 (14%)
Query: 266 ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
++LE + + I +L +E+E + +E K +A+ V +++ + +LE
Sbjct: 339 KALEEDLQIATKTICQLTEEKETQ---MEESNKARAAHSFVVTEFETTVCSLEELLRTEQ 395
Query: 326 QKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNEL---QQTINK 382
Q+L +++ + +E + E + + +N++ + +++++ E+ L + K
Sbjct: 396 QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEK 455
Query: 383 LTKDLEAEQQKLWNEELKYARGKEA--IETQLA------EYHKLARKLKLIPKGAENSKG 434
+ ++L+ +Q+L L AR KE +E QL +Y+ ++++K + EN K
Sbjct: 456 IAEELKGTEQELIG--LLQAREKEVHDLEIQLTAITTSEQYY--SKEVKDLKTELENEK- 510
Query: 435 YDFEIKFNPEAGANCLVKYRAQVYVPLKELLNET----------EEEINKALNKKMGLED 484
+K N E ++C ++ + KEL ET +E+IN ++ +
Sbjct: 511 ----LK-NTELTSHC-----NKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLK 560
Query: 485 TLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLES 544
+E L T+ + + ++EE+++ D + K+ ++EE ++E+ K+ L+
Sbjct: 561 QIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQ 620
Query: 545 TVNQGL-------SEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVE 597
N+ L S+ +N + + +L +++ ++ ++ + Q+ +E +
Sbjct: 621 E-NKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIE---------D 670
Query: 598 KHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKK 633
K + E+ + E + ++++ + KEI + + K
Sbjct: 671 KKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHK 706
Score = 47.4 bits (111), Expect = 4e-05
Identities = 76/401 (18%), Positives = 177/401 (44%), Gaps = 37/401 (9%)
Query: 254 LKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAY 313
L+ + N D E L+ + +E ++R+ + KE E ++K K S + ++++ +
Sbjct: 77 LEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEA---EKIKKWKVSTEAELRQKE-- 131
Query: 314 MSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHER 373
S L+ + I++ + + E ++ E + + +L+ I K + + H
Sbjct: 132 -SKLQENRKIIEAQRKAIQE----LQFGNEKV---SLKLEEGIQENKDLIKENNATRHLC 183
Query: 374 NELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSK 433
N L++T + + + + + Y IE + + +L + AENS+
Sbjct: 184 NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQ-------AENSR 236
Query: 434 -GYDFEIKFNPEAGANCLVKYRAQVYVPLKE---LLNETEEEINKALNKKMGLEDTLEQL 489
F++K + E + +Y+ ++ K+ LL + E+ NK + LE++ +++
Sbjct: 237 LEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKV 296
Query: 490 NAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQG 549
N + ++K LK+ ++K L +++++ + ++ S ++LE+ + T+ Q
Sbjct: 297 NQLEEKTKLQSENLKQSIEKQHHL-TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
Query: 550 LSE---AMNELDAVQREYQLVV---QTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQ 603
E M E + + + VV +TT ++ Q+ LE + K L +
Sbjct: 356 TEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQL----KILTME 411
Query: 604 IAKVDREYEEC--MSEDLSENIKEIRDKYEKKATLIKSSEE 642
+ K E EE ++ + ++E++ +K TL+ +++
Sbjct: 412 LQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQ 452
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/476 (20%), Positives = 206/476 (43%), Gaps = 56/476 (11%)
Query: 216 EDGIMHNKLFLDYTIKCYESFMSGADS--------FDEMNAELQSKLKDL-FNVDAFKLE 266
+DGI+ N L I+ + M+ +S N+ LQ ++ L +D K +
Sbjct: 875 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQ 934
Query: 267 SLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQ 326
+ E + + + L+ +EK + +++++ + +L + +Y +S L + +A+L+
Sbjct: 935 NQEKEKKCFED----LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNS 990
Query: 327 KLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIE---------------RINH 371
KL + R+E E E+ + D + S ++E ++N
Sbjct: 991 KLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNF 1050
Query: 372 ERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIP-KGAE 430
+ + L+ L++ L + KL + E+++ ++A+ + ++ + L + E
Sbjct: 1051 DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKE 1110
Query: 431 NSKGYDFE-IKFNPEAGANCLVKYR-AQVYVPLKELLNETEEEINKALNKKMGLEDTLEQ 488
+ Y E +K N G V+ R +Q+ L + ++ NKA NK+ + + +Q
Sbjct: 1111 MEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1170
Query: 489 LNAMI----TESKRSVRTLKEEVQKL-DDLYQQKIKEAEEEDEKCASELESLEKHKHLLE 543
+A++ ES++ L+E ++L + K ++ + E+EK E+ + + L +
Sbjct: 1171 FHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELAD 1230
Query: 544 STVNQGLSEAMNELDAVQREYQLVVQTTTEERRK----VGNNLQ----------RLLEMV 589
+ Q +SEA E V Y++ ++ T++ +K + N LQ R E +
Sbjct: 1231 TLKKQSMSEASLE---VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKM 1287
Query: 590 ATHVGSVEK---HLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
H +EK L+ + K + EE L+ N+ E + KK +K S E
Sbjct: 1288 QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLE 1343
Score = 60.8 bits (146), Expect = 4e-09
Identities = 85/405 (20%), Positives = 174/405 (42%), Gaps = 51/405 (12%)
Query: 265 LESLEAKNRALNEQIARLEQER---EKEPNRLESLRKLK-------ASLQGDVQKYQAYM 314
L++LE + R + + ++ QER +++ +R ++ R L+ S Q +++ Q M
Sbjct: 837 LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Query: 315 SNLESHS----AILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
++ SHS L K + L EEIA + LE +TIK +N + +K D++ +
Sbjct: 897 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLKIVK 950
Query: 371 HERNELQQTINK----LTKD----------LEAEQQKLWNEELKYARGKEAIETQLAEYH 416
+ +LQ+TI + LT+ L AE L ++ + KE +E ++ YH
Sbjct: 951 EKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYH 1010
Query: 417 KLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVP--------LKELLNET 468
+E SK + E+ F ++ + V L + L +T
Sbjct: 1011 SRLAAAIHDRDQSETSK-RELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKT 1069
Query: 469 EEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQ---KIKEAEEED 525
E ++N + D L + + ++ + + ++++++ YQ K+ + +
Sbjct: 1070 ESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQ 1129
Query: 526 EKCASELESLEKHKHLLESTVNQGLSEAMNELDAV---QREYQLVVQTTTEERRKVGNNL 582
E L L+ LL ++ ++A N+ V Q ++ +VQ E K L
Sbjct: 1130 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1189
Query: 583 -QRLLEMVATHVGSVEKHLEEQIAKVDRE-YEECMSEDLSENIKE 625
+R E+++ E+ + + K +RE + ++L++ +K+
Sbjct: 1190 EERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1234
Score = 50.8 bits (120), Expect = 4e-06
Identities = 95/469 (20%), Positives = 193/469 (41%), Gaps = 61/469 (13%)
Query: 182 VAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETED---GIMHNKLFLDYTIKCYESFMS 238
+A L ID IK KE F+D + E+ ED I N+ L TI Y +S
Sbjct: 921 IAMLRLEIDTIKNQNQEKEKK-CFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLS 979
Query: 239 GADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRK 298
+ NA L SKL++ + E LEA+ + + ++A +R++ L
Sbjct: 980 VLTA---ENAMLNSKLEN----EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL 1032
Query: 299 LKASLQGDVQKYQAYM----SNLESHSAILDQKLNGLNEEIARVELEC----ETIKQENT 350
+ + + Q M SNL+ ++ IL Q+L ++ +E+E + ++++
Sbjct: 1033 AFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1092
Query: 351 RLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKL---------WNEELKY 401
L+ + + + ++ + + Q +NK E+ +++L ++L
Sbjct: 1093 GLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDD 1152
Query: 402 ARGKEAIETQLA-----EYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCL-VKYRA 455
A K + + ++H + +KL+ AE+ K + N E + C +K R
Sbjct: 1153 AHNKADNKEKTVINIQDQFHAIVQKLQ-----AESEKQSLLLEERNKELISECNHLKERQ 1207
Query: 456 QVYVPLKE----LLNETEEEINKALNKKMGLEDTLE-------QLNAMITESKRSVRTLK 504
Y K ++ + ++E+ L K+ E +LE L + K+ + ++
Sbjct: 1208 YQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIR 1267
Query: 505 EEVQKLDDLYQQKIKEAEE-EDEKCASELES----------LEKHKHLLESTVNQGLSEA 553
++Q+ D + + ++ AE+ +D K E ++ ++K + L ++ +N LSE
Sbjct: 1268 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSED 1327
Query: 554 MNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEE 602
E E + ++ ++ K L+R + + K L E
Sbjct: 1328 EKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNE 1376
Score = 38.1 bits (87), Expect = 0.025
Identities = 43/210 (20%), Positives = 89/210 (42%), Gaps = 28/210 (13%)
Query: 461 LKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQ---QK 517
+++ +N + E+++ K LE + + + S+ +E+ + D LY+ ++
Sbjct: 756 MEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 815
Query: 518 IKEAEEEDEKCASELESLEKHKHLLE---STVNQGLSEAMNELDAVQREYQLVVQTTTEE 574
++ EE+ K + LE LE TV L++ + E + QR+ +
Sbjct: 816 LRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQ 875
Query: 575 RRKVGNNL--QRLLEMVATHVGSVEKH--------------LEEQIAKVDREYEECMSED 618
+ N+L Q+ +EM + S H L+E+IA + E + +++
Sbjct: 876 DGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQN 935
Query: 619 LS------ENIKEIRDKYEKKATLIKSSEE 642
E++K +++K E IK +EE
Sbjct: 936 QEKEKKCFEDLKIVKEKNEDLQKTIKQNEE 965
Score = 37.4 bits (85), Expect = 0.043
Identities = 81/400 (20%), Positives = 155/400 (38%), Gaps = 38/400 (9%)
Query: 242 SFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKA 301
+ E E KL +L L+ KN L +I + + +L +
Sbjct: 1323 NLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEF 1382
Query: 302 SLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKY 361
S GD++ Q M + L K++ L E+ +C + +N LQ + + K
Sbjct: 1383 SFHGDLKTSQFEM---DIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKT 1439
Query: 362 SVADIERINHERNELQQTINKLTKDLEAE-----QQKLWNEELKYARGKEAIETQLAEYH 416
E++ + +L+Q + L +E Q K + +E++ R ++ I +L E +
Sbjct: 1440 VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE-ERARQEIAEKLKEVN 1498
Query: 417 KLARKLKLIPKGAENSKGYDF-EIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINK- 474
+ + E + +F +K E L +++ +E N+TE E K
Sbjct: 1499 LFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTS-QEDFNKTELEKYKQ 1557
Query: 475 ----ALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKL-DDLYQQKIKEAEEEDEKCA 529
L + L L + N + E + K++ + L L + + E C
Sbjct: 1558 LYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVME-----PPCV 1612
Query: 530 SELES-------LEKHKHLLESTVNQGLS--EAMNELDAVQREYQLVVQTTTEERRKVGN 580
L + L ++L+ ST N S N L +Q+E + + T E ++
Sbjct: 1613 GNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELE---KNITRELKEAAA 1669
Query: 581 NLQRLLEMVATHVGSV-EKHLEEQIA-KVDREYEECMSED 618
L+ +A+ +GS E +L + + K REY + + ++
Sbjct: 1670 ELES--GSIASPLGSTDESNLNQDLVWKASREYVQVLKKN 1707
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 71.2 bits (173), Expect = 3e-12
Identities = 85/446 (19%), Positives = 193/446 (43%), Gaps = 45/446 (10%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNV----------DA 262
E + +M KL L ++ + A+ E+ A L +K ++L + +
Sbjct: 872 ETLQSQLMAEKLQLQEQLQAETELCAEAE---ELRARLTAKKQELEEICHDLEARVEEEE 928
Query: 263 FKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSA 322
+ + L+A+ + + + I LE++ E+E + + L+ K + + ++K + LE +
Sbjct: 929 ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 323 ILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIE----RINHERNELQQ 378
L ++ L + IA ++++ L + + + + D+E R +R EL++
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 379 TINKLTKD-------LEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAEN 431
T KL D + Q ++ +++ A+ +E ++ LA + A + + K
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 432 SKGYDFEIKFNPE---AGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQ 488
+ E++ + E A N K + + L+ L E E+ ++ ++ ++
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 489 LNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQ 548
+N + + +T + ++Q++ + Q ++E E+ E+ +LEK K LE
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE----- 1223
Query: 549 GLSEAMNELDAVQREYQLVVQ---TTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIA 605
NE + E ++++Q + +R+KV LQ L++ V L +++
Sbjct: 1224 ------NERGELANEVKVLLQGKGDSEHKRKKVEAQLQE-LQVKFNEGERVRTELADKVT 1276
Query: 606 KVDREYEE---CMSEDLSENIKEIRD 628
K+ E + +S+ S++ K +D
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKD 1302
Score = 64.3 bits (155), Expect = 3e-10
Identities = 100/471 (21%), Positives = 193/471 (40%), Gaps = 63/471 (13%)
Query: 193 KIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQS 252
K+ ++E F++G+ E D + ++ LD S + + + L+S
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 253 KLKDLFNVD----------AFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKAS 302
+L+D + + KL+ +E + + EQ LE+E E + N + + L A
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ---LEEEEEAKHNLEKQIATLHAQ 1365
Query: 303 LQGDVQKYQAYMSNLESHSAI---LDQKLNGLNEEIARVELECETIKQENTRLQN----- 354
+ +K + + LE+ + L + L GL++ + +++ TRLQ
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 355 --IIDNQKYSVADIERINHERNEL---QQTINKLTKD----LEAEQQKLWNEELKYARGK 405
+D+Q+ S ++E+ + ++L ++TI+ + EAE ++ + L AR
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL 1485
Query: 406 EAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELL 465
E Q AE +L ++ + + +SK + E L Q +K L
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL----EQQVEEMKTQL 1541
Query: 466 NETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEED 525
E E+E+ + K+ LE L+ + A E R + E +K + Q + EAE ED
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQF-ERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 526 E------------KCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTE 573
E K +L+ LE H + N+ EA+ +L +Q + + ++ +
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAH----IDSANKNRDEAIKQLRKLQAQMKDCMRELDD 1656
Query: 574 ER-------RKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSE 617
R + N ++L M A + L+E++A +R + E
Sbjct: 1657 TRASREEILAQAKENEKKLKSMEAEMI-----QLQEELAAAERAKRQAQQE 1702
Score = 59.7 bits (143), Expect = 8e-09
Identities = 74/386 (19%), Positives = 165/386 (42%), Gaps = 44/386 (11%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQ 308
E++ K A +LE + L + LE ER + N ++ L + K + +
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 309 KYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIK-------QENTRLQNIIDNQKY 361
K +A + L+ ++ L +++ ++++E + + ++++L +
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 362 SVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARK 421
+ D + + E N + +++ K +E E+ + + K +E Q+A H
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 422 LKLIPKGAENSKGYDFEIKFNPEAGANCL---VKYRAQVYVPLKELLNETEEEI---NKA 475
+K K E+S G CL + + ++ L+ L EE++ +K
Sbjct: 1369 MK---KKMEDSVG--------------CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411
Query: 476 LNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLY-QQKIKEAEEEDEKCASELES 534
K L+ L+ L + ++S L+++ +K D L ++K A+ +E+ +E E+
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471
Query: 535 LEKHKHLLESTVNQGLSEAMN---ELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVAT 591
EK L ++ + L EAM EL+ + ++++ ++ + VG ++ L +
Sbjct: 1472 REKETKAL--SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS--- 1526
Query: 592 HVGSVEKHLEEQIAKVDREYEECMSE 617
++ LE+Q+ ++ + EE E
Sbjct: 1527 -----KRALEQQVEEMKTQLEELEDE 1547
Score = 53.1 bits (126), Expect = 8e-07
Identities = 45/186 (24%), Positives = 94/186 (50%), Gaps = 9/186 (4%)
Query: 450 LVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQK 509
LVK R + + + L E E ++ + +K+ L++ L+ + E++ L + Q+
Sbjct: 854 LVKVREK-QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912
Query: 510 LDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQ 569
L+++ EEE+E+C + L+ K ++ + Q L E + E ++ +++ QL +
Sbjct: 913 LEEICHDLEARVEEEEERC----QHLQAEKKKMQQNI-QELEEQLEEEESARQKLQL-EK 966
Query: 570 TTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDK 629
TTE + K Q +LE + +K LE++IA+ E E+ S+++ ++++K
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE--EEEKSKSLAKLKNK 1024
Query: 630 YEKKAT 635
+E T
Sbjct: 1025 HEAMIT 1030
Score = 39.3 bits (90), Expect = 0.011
Identities = 59/247 (23%), Positives = 100/247 (40%), Gaps = 43/247 (17%)
Query: 267 SLEAKNRALNEQIARLEQEREKEPNRLESL--RKLKASLQGDVQKYQAYMSNLESHSAIL 324
+LE K R L +IA+LE+E E+E E + R KA+LQ +
Sbjct: 1720 ALEEKRR-LEARIAQLEEELEEEQGNTELINDRLKKANLQ-------------------I 1759
Query: 325 DQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLT 384
DQ LN E + + K EN R Q N++ V E +++ + +I L
Sbjct: 1760 DQINTDLNLERSHAQ------KNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 385 KDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPE 444
+ +++L NE KE + + + +KLK + ++ + + K +
Sbjct: 1814 AKIAQLEEQLDNET------KER-QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Query: 445 AGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLK 504
+ L + LK L E EEE +A + L+ LE R V +LK
Sbjct: 1867 KASTRLKQ--------LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLK 1918
Query: 505 EEVQKLD 511
++++ D
Sbjct: 1919 NKLRRGD 1925
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 71.2 bits (173), Expect = 3e-12
Identities = 93/421 (22%), Positives = 174/421 (41%), Gaps = 43/421 (10%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALN----------EQIARLEQEREKEPNRL 293
DE A+L + K L L+ L+A+ +N +Q+ LE E+E
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIR 1049
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQ 353
L + K L+GD++ Q ++E+ LD+KL E++ ++ + E + +LQ
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQ 1109
Query: 354 NIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL- 412
I + + ++E + K DL E +++ +E L+ A G + + ++
Sbjct: 1110 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI-SERLEEAGGATSAQIEMN 1168
Query: 413 ----AEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNET 468
AE+ K+ R L+ E EA A L K A L E ++
Sbjct: 1169 KKREAEFQKMRRDLE--------------EATLQHEATAATLRKKHADSVAELGEQIDNL 1214
Query: 469 EEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKC 528
+ K +K ++ ++ L + + ++ L++ + L+D + IK EEE ++
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSE-IKTKEEEQQRL 1273
Query: 529 ASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEM 588
++L + ++ L E + + R Q Q E +R++ ++ +
Sbjct: 1274 INDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSAL 1333
Query: 589 VATHVGS-------VEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSE 641
S E++ EEQ AK E + MS+ SE + + R KYE A I+ +E
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKA--ELQRAMSKANSE-VAQWRTKYETDA--IQRTE 1388
Query: 642 E 642
E
Sbjct: 1389 E 1389
Score = 64.3 bits (155), Expect = 3e-10
Identities = 80/400 (20%), Positives = 166/400 (41%), Gaps = 36/400 (9%)
Query: 242 SFDEMNAELQSKLKDLFNVDAF-KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK 300
+ + N+E+ ++ + + DA + E LE + L +++ E+ E + SL K K
Sbjct: 1364 AMSKANSEV-AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTK 1422
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE-----------N 349
LQ +V+ + + A LD+K ++ +A + +CE E +
Sbjct: 1423 QRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLS 1482
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDL--------EAEQQKLWNEELKY 401
T L I + + S+ +E + E LQQ I+ LT+ + E E+ K E+ K
Sbjct: 1483 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKS 1542
Query: 402 ARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPL 461
E + + H+ + L++ + + D +I E + + + ++ +
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE-IDQMKRNHIRIVESM 1601
Query: 462 KELLNETEEEINKALNKKMGLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDLYQQK 517
+ L+ N A+ K +E L ++ + + R ++R + L D Q
Sbjct: 1602 QSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT-QLH 1660
Query: 518 IKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRK 577
+ +A E +L +E+ +LL++ + E L+ +R ++ Q + +
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEI----EELRATLEQTERSRKIAEQELLDASER 1716
Query: 578 VGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSE 617
V +LL T + + +K LE I+++ E E+ + E
Sbjct: 1717 V-----QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQE 1751
Score = 62.0 bits (149), Expect = 2e-09
Identities = 106/450 (23%), Positives = 199/450 (44%), Gaps = 79/450 (17%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFN--------VDAFK 264
EE D ++ K+ L+ IK A+ +E+NAEL +K + L + +D +
Sbjct: 906 EERCDQLIKTKIQLEAKIK---EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 265 L---------ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMS 315
L + E K + L E++A L++ + L K K +LQ + +Q +
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDE-------TIAKLTKEKKALQ---EAHQQTLD 1012
Query: 316 NLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNE 375
+L++ + K+N L + A+++LE Q+ L+ ++ +K D+ER +
Sbjct: 1013 DLQAE----EDKVNTLTK--AKIKLE-----QQVDDLEGSLEQEKKIRMDLERAKRKLEG 1061
Query: 376 LQQTINKLTKDLEAEQQ----KLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAEN 431
+ + T D+E ++Q KL +E + + + IE + A +L +K+K + E
Sbjct: 1062 DLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIE- 1120
Query: 432 SKGYDFEIKFNPEAGANCLV-KYRAQVYVPLKELLNETEE---------EINK---ALNK 478
+ E + E + K R+ + L+E+ EE E+NK A +
Sbjct: 1121 ----ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1176
Query: 479 KM--GLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDLYQQKIKEAEE---EDEKCA 529
KM LE+ Q A ++ SV L E++ L + Q+ KE E E + A
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1236
Query: 530 SELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKV---GNNLQRLL 586
S +E++ K K LE + + L + ++E+ + E Q ++ T +R ++ R L
Sbjct: 1237 SNMETVSKAKGNLEK-MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL 1295
Query: 587 EMVATHVGSVEKHLE---EQIAKVDREYEE 613
+ T V + + + +QI ++ R+ EE
Sbjct: 1296 DEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Score = 61.2 bits (147), Expect = 3e-09
Identities = 83/417 (19%), Positives = 175/417 (41%), Gaps = 56/417 (13%)
Query: 252 SKLKDLFNVDAFKLESLEAKNRALNEQIARLEQERE--------------KEPNRLESLR 297
+ +K+ F +L EAK + L E++ L QE+ R + L
Sbjct: 854 ANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLI 913
Query: 298 KLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE-------IARVELECETIKQENT 350
K K L+ +++ + E +A L K L +E I +EL +++E
Sbjct: 914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 973
Query: 351 RLQNIIDNQKYSVADIE----RINHERNELQQTINKLTKDLEAEQQK---LWNEELKYAR 403
+N + N +A ++ ++ E+ LQ+ + DL+AE+ K L ++K +
Sbjct: 974 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1033
Query: 404 GKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKE 463
+ +E L + K+ L+ + E E + E L + + +
Sbjct: 1034 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
Query: 464 LLNETEEE--INKALNKKM--------GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL 513
L ++ E+E + L KK+ LE+ +E A ++++ L E++++ +
Sbjct: 1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 514 YQ----------QKIKEAEEEDEKCASELESLEKHKHLLESTVNQ----GLSEAMNELDA 559
+ + K+ E E +K +LE +T+ + ++E ++D
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1213
Query: 560 VQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK---HLEEQIAKVDREYEE 613
+QR Q + + +E + ++ ++L +E V+ G++EK LE+Q++++ + EE
Sbjct: 1214 LQRVKQKLEKEKSEMKMEI-DDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEE 1269
Score = 52.8 bits (125), Expect = 1e-06
Identities = 97/514 (18%), Positives = 206/514 (40%), Gaps = 122/514 (23%)
Query: 222 NKLFLDYTIKCYESFMSGADSFDE---MNAELQSKLKDLFNVDAFKLESLEAKNRALNEQ 278
+K+ ++ KC E+ S E ++ EL K+K+ + +LE+L+ +N+ L ++
Sbjct: 1454 DKILAEWKQKCEETHAELEASQKESRSLSTEL-FKIKNAYEESLDQLETLKRENKNLQQE 1512
Query: 279 IARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESH-----------SAILDQK 327
I+ L ++ + R+ L K+K ++ + + QA + E+ L+Q
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 328 LNGLNEEIARVELECETIKQENTRL----QNIIDNQKYSVADIERINHERNELQQTINKL 383
+ ++ +IA + E + +K+ + R+ Q+ +D + S D R+ + +++ +N++
Sbjct: 1573 KSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL---KKKMEGDLNEM 1629
Query: 384 TKDLEAEQQKLWNEELKYARGKEAI--ETQL------AEYHKLARKLKLIPKGAENSKGY 435
L ++ E L+ R +AI +TQL L +L ++ + A +
Sbjct: 1630 EIQLN-HANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAE 1688
Query: 436 DFEIKFNPEAGANC------------------------LVKYRAQVYVPLKELLNETEEE 471
E++ E L+ + ++ + ++ E E+
Sbjct: 1689 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748
Query: 472 INKALNK-------------------------------KMGLEDTLEQLNAMITESKR-S 499
I +A N K LE T++ L + E+++ +
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1808
Query: 500 VRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDA 559
++ K+++QKL+ ++ E E E ++ ++ L KH+ ++ Q
Sbjct: 1809 LKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ----------- 1857
Query: 560 VQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEE----------QIAKVDR 609
TEE RK LQ L++ + V S ++ EE + ++
Sbjct: 1858 ------------TEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 610 EYEECMSE-DLSEN-IKEIRDKYEKKATLIKSSE 641
E EE D++E+ + ++R K + T I S E
Sbjct: 1906 ELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 43.9 bits (102), Expect = 5e-04
Identities = 59/256 (23%), Positives = 114/256 (44%), Gaps = 41/256 (16%)
Query: 360 KYSVADIERINH-ERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKL 418
+Y+V + H +L I L K E E++ + N + ++ + KE + A+ +L
Sbjct: 819 QYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKE-MANMKEEFEKTKEELAKTEAKRKEL 877
Query: 419 ARKLKLIPKGAENSKGYDFEIKFNPEAGA--------NCLVKYRAQVYVPLKELLNETEE 470
K+ + + D +++ EA + + L+K + Q+ +KE+ E+
Sbjct: 878 EEKMVTLMQEKN-----DLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAED 932
Query: 471 EINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQK-LDDLYQQKIKEAEEEDEKCA 529
E E++NA +T KR + E++K +DDL ++ A+ E EK A
Sbjct: 933 E---------------EEINAELTAKKRKLEDECSELKKDIDDL---ELTLAKVEKEKHA 974
Query: 530 SELESLEKHKHLLE--STVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLE 587
+E K K+L E + +++ +++ E A+Q +Q + E KV N L +
Sbjct: 975 TE----NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV-NTLTKAKI 1029
Query: 588 MVATHVGSVEKHLEEQ 603
+ V +E LE++
Sbjct: 1030 KLEQQVDDLEGSLEQE 1045
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 71.2 bits (173), Expect = 3e-12
Identities = 93/421 (22%), Positives = 175/421 (41%), Gaps = 43/421 (10%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALN----------EQIARLEQEREKEPNRL 293
DE A+L + K L L+ L+A+ +N +Q+ LE E+E
Sbjct: 992 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQ 353
L + K L+GD++ Q + ++E+ LD+KL EI+ ++ + E + +LQ
Sbjct: 1052 MDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 354 NIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL- 412
I + + ++E + K DL E +++ +E L+ A G + + ++
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI-SERLEEAGGATSAQIEMN 1170
Query: 413 ----AEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNET 468
AE+ K+ R L+ E EA A L K A L E ++
Sbjct: 1171 KKREAEFQKMRRDLE--------------EATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 469 EEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKC 528
+ K +K ++ ++ L + + ++ L++ + L+D + +K EEE ++
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE-LKSKEEEQQRL 1275
Query: 529 ASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERR------KVGNNL 582
++L + ++ L E + + R Q Q E +R K N L
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 583 QRLLEMVATHVGSV-EKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSE 641
L+ + E++ EEQ +K E + +S+ +E + + R KYE A I+ +E
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKA--ELQRALSKANTE-VAQWRTKYETDA--IQRTE 1390
Query: 642 E 642
E
Sbjct: 1391 E 1391
Score = 64.3 bits (155), Expect = 3e-10
Identities = 85/407 (20%), Positives = 163/407 (40%), Gaps = 45/407 (11%)
Query: 245 EMNAELQSKL----------KDLFNVDAF-KLESLEAKNRALNEQIARLEQEREKEPNRL 293
E AELQ L + + DA + E LE + L +++ E+ E +
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE----- 348
SL K K LQ +V+ + + A LD+K ++ +A + +CE E
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 349 ------NTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDL--------EAEQQKL 394
T L I + + S+ +E + E LQQ I+ LT+ + E E+ K
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 395 WNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYR 454
E+ K E + + H+ + L++ + + D +I E + L +
Sbjct: 1538 QVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE-IDQLKRNH 1596
Query: 455 AQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKR----SVRTLKEEVQKL 510
++ ++ L+ N A+ K +E L ++ + + R ++R + L
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL 1656
Query: 511 DDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQT 570
D Q + +A E +L +E+ +LL++ + E L+ +R ++ Q
Sbjct: 1657 KDT-QIHLDDALRSQEDLKEQLAMVERRANLLQAEI----EELRATLEQTERSRKIAEQE 1711
Query: 571 TTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSE 617
+ +V +LL T + + +K LE I+++ E E+ + E
Sbjct: 1712 LLDASERV-----QLLHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Score = 62.0 bits (149), Expect = 2e-09
Identities = 113/495 (22%), Positives = 216/495 (43%), Gaps = 92/495 (18%)
Query: 193 KIHTAMKESSPLF------DDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEM 246
K+ T +KE + L +G EE D ++ K+ L+ IK A+ +E+
Sbjct: 882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK---EVTERAEDEEEI 938
Query: 247 NAELQSKLKDLFN--------VDAFKL---------ESLEAKNRALNEQIARLEQEREKE 289
NAEL +K + L + +D +L + E K + L E++A L++
Sbjct: 939 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE----- 993
Query: 290 PNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQEN 349
+ L K K +LQ + +Q + +L++ + K+N L + A+++LE Q+
Sbjct: 994 --TIAKLTKEKKALQ---EAHQQTLDDLQAE----EDKVNTLTK--AKIKLE-----QQV 1037
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQ----KLWNEELKYARGK 405
L+ ++ +K D+ER + + + D+E E+Q KL +E + + +
Sbjct: 1038 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQ 1097
Query: 406 EAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV-KYRAQVYVPLKEL 464
IE + A +L +K+K + E + E + E + K R+ + L+E+
Sbjct: 1098 SKIEDEQALGIQLQKKIKELQARIE-----ELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 465 LNETEE---------EINK---ALNKKM--GLEDTLEQLNAMITESKR----SVRTLKEE 506
EE E+NK A +KM LE+ Q A ++ SV L E+
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 507 VQKLDDLYQQKIKEAEE---EDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQRE 563
+ L + Q+ KE E E + AS +E++ K K LE + + L + ++EL + + E
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK-MCRTLEDQLSELKSKEEE 1271
Query: 564 YQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDR--EYEECMSEDLSE 621
Q ++ T +R + + T G + L+E+ A V + ++ ++ + E
Sbjct: 1272 QQRLINDLTAQRGR-----------LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 622 NIKEIRDKYEKKATL 636
+++ ++ + K L
Sbjct: 1321 LKRQLEEEIKAKNAL 1335
Score = 59.3 bits (142), Expect = 1e-08
Identities = 103/462 (22%), Positives = 195/462 (42%), Gaps = 55/462 (11%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDE----MNAELQSKLKDLFNVDAFKLESL 268
+E+ I + K LD +K E +S S E + +LQ K+K+L E +
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 269 EAK--------------NRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYM 314
EA+ +R L E RLE+ ++E +K +A Q + +
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 315 SNLESHSAILDQK----LNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
E+ +A L +K + L E+I ++ + +++E + ++ ID+ +V + +
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 371 HERNELQQTINKLTKDL---EAEQQKLWNEELKYARGKEAIETQLAEYHK-LARKLKLIP 426
++ +T+ +L E EQQ+L N+ L RG+ ++T+ E+ + L K L+
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLIND-LTAQRGR--LQTESGEFSRQLDEKEALVS 1305
Query: 427 KGAENSKGYDFEIK-----FNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMG 481
+ + + + +I+ E A + + Q +LL E EE ++ K
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES---KAE 1362
Query: 482 LEDTLEQLNAMITESKRSVRT----LKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEK 537
L+ L + N + + + T EE+++ Q+++ AEE E ++ SLEK
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 538 HKHLLESTVN------QGLSEAMNELDAVQREYQLVV---QTTTEERRKVGNNLQRLLEM 588
K L++ V + + A LD QR + ++ + EE Q+
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 589 VATHVGSVEKHLEE---QIAKVDREYEECMSE--DLSENIKE 625
+ T + ++ EE Q+ + RE + E DL+E I E
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524
Score = 49.7 bits (117), Expect = 8e-06
Identities = 82/415 (19%), Positives = 171/415 (41%), Gaps = 75/415 (18%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLE----SLRKLK 300
E + E+ ++ + +L+A+ R+ N+ I RL+++ E + N +E ++
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
A + + Q + + + H + L E++A VE ++ E L+
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELR------- 1695
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
A +E+ R +Q + D Q L + K+ +ET +++ +
Sbjct: 1696 ---ATLEQTERSRKIAEQEL----LDASERVQLLHTQNTSLINTKKKLETDISQ---MQG 1745
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNK-K 479
+++ I + A N+ E A + A + LK+ E++ + L + K
Sbjct: 1746 EMEDILQEARNA-----------EEKAKKAITDAAMMAEELKK-----EQDTSAHLERMK 1789
Query: 480 MGLEDTLEQLNAMITESKR-SVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKH 538
+E T++ L + E+++ +++ K+++QKL+ ++ E E E ++ A ++ L KH
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849
Query: 539 KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK 598
+ ++ Q TEE RK LQ L++ + V S ++
Sbjct: 1850 ERRVKELTYQ-----------------------TEEDRKNILRLQDLVDKLQAKVKSYKR 1886
Query: 599 HLEE----------QIAKVDREYEECMSE-DLSEN-IKEIRDKYEKKATLIKSSE 641
EE + K+ E EE D++E+ + ++R K + T + S E
Sbjct: 1887 QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 37.4 bits (85), Expect = 0.043
Identities = 39/192 (20%), Positives = 88/192 (45%), Gaps = 33/192 (17%)
Query: 461 LKELLNETEEEINKALNKKMGLED----TLEQLNAMITESKRSVRTLKEEVQKLDDLYQQ 516
+KE + ++E+ K+ K+ LE+ L++ N + + + L + ++ D L +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 517 KIK---------EAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLV 567
KI+ E E++E+ +EL + ++ L + +EL + +L
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRK-----------LEDECSELKKDIDDLELT 966
Query: 568 VQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIR 627
+ +E+ N ++ L E +A L+E IAK+ +E ++ + E + + +++
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMA--------GLDETIAKLTKE-KKALQEAHQQTLDDLQ 1017
Query: 628 DKYEKKATLIKS 639
+ +K TL K+
Sbjct: 1018 AEEDKVNTLTKA 1029
Score = 33.1 bits (74), Expect = 0.81
Identities = 32/128 (25%), Positives = 65/128 (50%), Gaps = 16/128 (12%)
Query: 495 ESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVN---QGLS 551
E+++ + T+KEE QK+ D ++ ++E + ++ ++ +L K K+ L+ V +GL+
Sbjct: 850 ETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 552 EAMNELD-AVQREYQL-----VVQTTTEERRKVGNNL---QRLLEMVATHVGSVEKHLEE 602
+A D ++ + QL V E+ ++ L +R LE + + LE
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 603 QIAKVDRE 610
+AKV++E
Sbjct: 966 TLAKVEKE 973
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 71.2 bits (173), Expect = 3e-12
Identities = 93/421 (22%), Positives = 175/421 (41%), Gaps = 43/421 (10%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALN----------EQIARLEQEREKEPNRL 293
DE A+L + K L L+ L+A+ +N +Q+ LE E+E
Sbjct: 992 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQ 353
L + K L+GD++ Q + ++E+ LD+KL EI+ ++ + E + +LQ
Sbjct: 1052 MDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 354 NIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL- 412
I + + ++E + K DL E +++ +E L+ A G + + ++
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI-SERLEEAGGATSAQIEMN 1170
Query: 413 ----AEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNET 468
AE+ K+ R L+ E EA A L K A L E ++
Sbjct: 1171 KKREAEFQKMRRDLE--------------EATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 469 EEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKC 528
+ K +K ++ ++ L + + ++ L++ + L+D + +K EEE ++
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE-LKSKEEEQQRL 1275
Query: 529 ASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERR------KVGNNL 582
++L + ++ L E + + R Q Q E +R K N L
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 583 QRLLEMVATHVGSV-EKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSE 641
L+ + E++ EEQ +K E + +S+ +E + + R KYE A I+ +E
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKA--ELQRALSKANTE-VAQWRTKYETDA--IQRTE 1390
Query: 642 E 642
E
Sbjct: 1391 E 1391
Score = 64.3 bits (155), Expect = 3e-10
Identities = 85/407 (20%), Positives = 163/407 (40%), Gaps = 45/407 (11%)
Query: 245 EMNAELQSKL----------KDLFNVDAF-KLESLEAKNRALNEQIARLEQEREKEPNRL 293
E AELQ L + + DA + E LE + L +++ E+ E +
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE----- 348
SL K K LQ +V+ + + A LD+K ++ +A + +CE E
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 349 ------NTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDL--------EAEQQKL 394
T L I + + S+ +E + E LQQ I+ LT+ + E E+ K
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 395 WNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYR 454
E+ K E + + H+ + L++ + + D +I E + L +
Sbjct: 1538 QVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE-IDQLKRNH 1596
Query: 455 AQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKR----SVRTLKEEVQKL 510
++ ++ L+ N A+ K +E L ++ + + R ++R + L
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL 1656
Query: 511 DDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQT 570
D Q + +A E +L +E+ +LL++ + E L+ +R ++ Q
Sbjct: 1657 KDT-QIHLDDALRSQEDLKEQLAMVERRANLLQAEI----EELRATLEQTERSRKIAEQE 1711
Query: 571 TTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSE 617
+ +V +LL T + + +K LE I+++ E E+ + E
Sbjct: 1712 LLDASERV-----QLLHTQNTSLINTKKKLETDISQMQGEMEDILQE 1753
Score = 62.0 bits (149), Expect = 2e-09
Identities = 113/495 (22%), Positives = 216/495 (43%), Gaps = 92/495 (18%)
Query: 193 KIHTAMKESSPLF------DDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEM 246
K+ T +KE + L +G EE D ++ K+ L+ IK A+ +E+
Sbjct: 882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIK---EVTERAEDEEEI 938
Query: 247 NAELQSKLKDLFN--------VDAFKL---------ESLEAKNRALNEQIARLEQEREKE 289
NAEL +K + L + +D +L + E K + L E++A L++
Sbjct: 939 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE----- 993
Query: 290 PNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQEN 349
+ L K K +LQ + +Q + +L++ + K+N L + A+++LE Q+
Sbjct: 994 --TIAKLTKEKKALQ---EAHQQTLDDLQAE----EDKVNTLTK--AKIKLE-----QQV 1037
Query: 350 TRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQ----KLWNEELKYARGK 405
L+ ++ +K D+ER + + + D+E E+Q KL +E + + +
Sbjct: 1038 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQ 1097
Query: 406 EAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV-KYRAQVYVPLKEL 464
IE + A +L +K+K + E + E + E + K R+ + L+E+
Sbjct: 1098 SKIEDEQALGIQLQKKIKELQARIE-----ELEEEIEAERASRAKAEKQRSDLSRELEEI 1152
Query: 465 LNETEE---------EINK---ALNKKM--GLEDTLEQLNAMITESKR----SVRTLKEE 506
EE E+NK A +KM LE+ Q A ++ SV L E+
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 507 VQKLDDLYQQKIKEAEE---EDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQRE 563
+ L + Q+ KE E E + AS +E++ K K LE + + L + ++EL + + E
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK-MCRTLEDQLSELKSKEEE 1271
Query: 564 YQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDR--EYEECMSEDLSE 621
Q ++ T +R + + T G + L+E+ A V + ++ ++ + E
Sbjct: 1272 QQRLINDLTAQRGR-----------LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEE 1320
Query: 622 NIKEIRDKYEKKATL 636
+++ ++ + K L
Sbjct: 1321 LKRQLEEEIKAKNAL 1335
Score = 59.3 bits (142), Expect = 1e-08
Identities = 103/462 (22%), Positives = 195/462 (42%), Gaps = 55/462 (11%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDE----MNAELQSKLKDLFNVDAFKLESL 268
+E+ I + K LD +K E +S S E + +LQ K+K+L E +
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI 1128
Query: 269 EAK--------------NRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYM 314
EA+ +R L E RLE+ ++E +K +A Q + +
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 315 SNLESHSAILDQK----LNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
E+ +A L +K + L E+I ++ + +++E + ++ ID+ +V + +
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAK 1248
Query: 371 HERNELQQTINKLTKDL---EAEQQKLWNEELKYARGKEAIETQLAEYHK-LARKLKLIP 426
++ +T+ +L E EQQ+L N+ L RG+ ++T+ E+ + L K L+
Sbjct: 1249 GNLEKMCRTLEDQLSELKSKEEEQQRLIND-LTAQRGR--LQTESGEFSRQLDEKEALVS 1305
Query: 427 KGAENSKGYDFEIK-----FNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMG 481
+ + + + +I+ E A + + Q +LL E EE ++ K
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES---KAE 1362
Query: 482 LEDTLEQLNAMITESKRSVRT----LKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEK 537
L+ L + N + + + T EE+++ Q+++ AEE E ++ SLEK
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 538 HKHLLESTVN------QGLSEAMNELDAVQREYQLVV---QTTTEERRKVGNNLQRLLEM 588
K L++ V + + A LD QR + ++ + EE Q+
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 589 VATHVGSVEKHLEE---QIAKVDREYEECMSE--DLSENIKE 625
+ T + ++ EE Q+ + RE + E DL+E I E
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1524
Score = 49.7 bits (117), Expect = 8e-06
Identities = 82/415 (19%), Positives = 171/415 (41%), Gaps = 75/415 (18%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLE----SLRKLK 300
E + E+ ++ + +L+A+ R+ N+ I RL+++ E + N +E ++
Sbjct: 1584 EKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMA 1642
Query: 301 ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
A + + Q + + + H + L E++A VE ++ E L+
Sbjct: 1643 AEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELR------- 1695
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
A +E+ R +Q + D Q L + K+ +ET +++ +
Sbjct: 1696 ---ATLEQTERSRKIAEQEL----LDASERVQLLHTQNTSLINTKKKLETDISQ---MQG 1745
Query: 421 KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNK-K 479
+++ I + A N+ E A + A + LK+ E++ + L + K
Sbjct: 1746 EMEDILQEARNA-----------EEKAKKAITDAAMMAEELKK-----EQDTSAHLERMK 1789
Query: 480 MGLEDTLEQLNAMITESKR-SVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKH 538
+E T++ L + E+++ +++ K+++QKL+ ++ E E E ++ A ++ L KH
Sbjct: 1790 KNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849
Query: 539 KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK 598
+ ++ Q TEE RK LQ L++ + V S ++
Sbjct: 1850 ERRVKELTYQ-----------------------TEEDRKNILRLQDLVDKLQAKVKSYKR 1886
Query: 599 HLEE----------QIAKVDREYEECMSE-DLSEN-IKEIRDKYEKKATLIKSSE 641
EE + K+ E EE D++E+ + ++R K + T + S E
Sbjct: 1887 QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 37.4 bits (85), Expect = 0.043
Identities = 39/192 (20%), Positives = 88/192 (45%), Gaps = 33/192 (17%)
Query: 461 LKELLNETEEEINKALNKKMGLED----TLEQLNAMITESKRSVRTLKEEVQKLDDLYQQ 516
+KE + ++E+ K+ K+ LE+ L++ N + + + L + ++ D L +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 517 KIK---------EAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLV 567
KI+ E E++E+ +EL + ++ L + +EL + +L
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRK-----------LEDECSELKKDIDDLELT 966
Query: 568 VQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIR 627
+ +E+ N ++ L E +A L+E IAK+ +E ++ + E + + +++
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMA--------GLDETIAKLTKE-KKALQEAHQQTLDDLQ 1017
Query: 628 DKYEKKATLIKS 639
+ +K TL K+
Sbjct: 1018 AEEDKVNTLTKA 1029
Score = 33.1 bits (74), Expect = 0.81
Identities = 32/128 (25%), Positives = 65/128 (50%), Gaps = 16/128 (12%)
Query: 495 ESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVN---QGLS 551
E+++ + T+KEE QK+ D ++ ++E + ++ ++ +L K K+ L+ V +GL+
Sbjct: 850 ETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 552 EAMNELD-AVQREYQL-----VVQTTTEERRKVGNNL---QRLLEMVATHVGSVEKHLEE 602
+A D ++ + QL V E+ ++ L +R LE + + LE
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 603 QIAKVDRE 610
+AKV++E
Sbjct: 966 TLAKVEKE 973
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 42/408 (10%)
Query: 251 QSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKY 310
Q L DL ++ K+ +L L +Q+ LE E+E L + K L+GD++
Sbjct: 1008 QQTLDDL-QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLA 1066
Query: 311 QAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERIN 370
Q + E+ L++KL E++ ++ + E + +LQ I + + ++E
Sbjct: 1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126
Query: 371 HERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL-----AEYHKLARKLKLI 425
+ K DL E +++ +E L+ A G + + ++ AE+ K+ R L+
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEI-SERLEEAGGATSAQIEMNKKREAEFQKMRRDLE-- 1183
Query: 426 PKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDT 485
E EA A L K A L E ++ + K +K L+
Sbjct: 1184 ------------ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 486 LEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLEST 545
+ L + + ++ ++ + L+D + IK EEE ++ +EL + + H T
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSE-IKTKEEEQQRLINELSAQKARLH----T 1286
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSV--------- 596
+ S ++E DA+ + Q T++ ++ L+ + +T ++
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDL 1346
Query: 597 --EKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
E++ EEQ AK E + MS+ SE + + R KYE A I+ +EE
Sbjct: 1347 LREQYEEEQEAKA--ELQRGMSKANSE-VAQWRTKYETDA--IQRTEE 1389
Score = 63.2 bits (152), Expect = 7e-10
Identities = 82/404 (20%), Positives = 168/404 (41%), Gaps = 81/404 (20%)
Query: 234 ESFMSGADSFDEMNAELQSKLKDLFNVDAFKLES----LEAKNRALNEQIARLEQEREKE 289
E+ S S ++ LQ++++DL +D + + L+ K R ++ +A +Q+ E+
Sbjct: 1409 EAVNSKCASLEKTKQRLQNEVEDLM-IDVERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467
Query: 290 PNRLESLRKLKASLQGDVQKYQ-AYMSNLESHSAILDQKLNGLNEEIARVELECETIKQE 348
LE+ +K SL ++ K + AY +L+ ET+K+E
Sbjct: 1468 QAELEASQKESRSLSTELFKVKNAYEESLD----------------------HLETLKRE 1505
Query: 349 NTRLQNIIDNQKYSVAD-----------IERINHERNELQQTINKLTKDLEAEQQKLWNE 397
N LQ I + +A+ ++++HE++ELQ ++ + LE E+ K+
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565
Query: 398 ELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQV 457
+L+ + K I+ ++AE + +LK + +V
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLK----------------------------RNHLRV 1597
Query: 458 YVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDL 513
++ L+ N AL K +E L ++ + + R ++R L+ L D
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 514 YQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTE 573
Q + +A + +L +E+ +L+++ V E L+ +R ++ Q +
Sbjct: 1658 -QLHLDDAIRGQDDLKEQLAMVERRANLMQAEV----EELRASLERTERGRKMAEQELLD 1712
Query: 574 ERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSE 617
+V +LL T + + +K LE I+++ E E+ + E
Sbjct: 1713 ASERV-----QLLHTQNTSLINTKKKLETDISQIQGEMEDIVQE 1751
Score = 62.0 bits (149), Expect = 2e-09
Identities = 101/468 (21%), Positives = 195/468 (41%), Gaps = 84/468 (17%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFN--------VDAFK 264
EE D ++ K+ L+ IK A+ +E+NAEL +K + L + +D +
Sbjct: 906 EERCDQLIKTKIQLEAKIK---EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 265 L---------ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMS 315
L + E K + L E++A L++ K ++L++ D+Q + ++
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN 1022
Query: 316 NLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNE 375
L L+Q+++ L + + + C +++ +L+ + + S D E + NE
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE 1082
Query: 376 LQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGY 435
KL +E + + + IE + A +L +K+K + E
Sbjct: 1083 -----------------KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE----- 1120
Query: 436 DFEIKFNPEAGANCLV-KYRAQVYVPLKELLNETEE---------EINK---ALNKKM-- 480
+ E + E + K R+ + L+E+ EE E+NK A +KM
Sbjct: 1121 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 481 GLEDTLEQLNAMITESKR----SVRTLKEEVQKLDDLYQQKIKEAEE---EDEKCASELE 533
LE++ Q A ++ SV L E++ L + Q+ KE E E AS +E
Sbjct: 1181 DLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNME 1240
Query: 534 SLEKHKHLLES---TVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVA 590
++ K K E T+ LSE ++T EE++++ N L +
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSE---------------IKTKEEEQQRLINELSAQKARLH 1285
Query: 591 THVGSVEKHLEEQIAKVDR--EYEECMSEDLSENIKEIRDKYEKKATL 636
T G + L+E+ A V + ++ ++ + E +++ ++ + K+TL
Sbjct: 1286 TESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTL 1333
Score = 59.3 bits (142), Expect = 1e-08
Identities = 93/425 (21%), Positives = 177/425 (41%), Gaps = 72/425 (16%)
Query: 252 SKLKDLFNVDAFKLESLEAKNRALNEQIARLEQERE--------------KEPNRLESLR 297
+ +K+ F +L EAK + L E++ L QE+ R + L
Sbjct: 854 ANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLI 913
Query: 298 KLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE-------IARVELECETIKQENT 350
K K L+ +++ + E +A L K L +E I +EL +++E
Sbjct: 914 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 973
Query: 351 RLQNIIDNQKYSVADIE----RINHERNELQQTINKLTKDLEAEQQK---LWNEELKYAR 403
+N + N +A ++ ++ E+ LQ+ + DL+ E+ K L + K +
Sbjct: 974 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQ 1033
Query: 404 GKEAIETQLAEYHKLA-------RKLKLIPKGAENS---------------KGYDFEIKF 441
+ +E L + KL RKL+ K A+ S K +FE+
Sbjct: 1034 QVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMS- 1092
Query: 442 NPEAGANCLVKYRAQVYVPLKEL---LNETEEEIN-------KALNKKMGLEDTLEQLNA 491
N + Q+ +KEL + E EEEI KA ++ L LE+++
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1152
Query: 492 MITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLS 551
+ E+ + E +K + +Q+ ++ EE + + +L K KH ++
Sbjct: 1153 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRK-KHA------DSVA 1205
Query: 552 EAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK---HLEEQIAKVD 608
E ++D++QR Q + + +E + ++ N+L +E V+ + EK LE+Q++++
Sbjct: 1206 ELGEQIDSLQRVKQKLEKEKSELKMEI-NDLASNMETVSKAKANFEKMCRTLEDQLSEIK 1264
Query: 609 REYEE 613
+ EE
Sbjct: 1265 TKEEE 1269
Score = 56.6 bits (135), Expect = 7e-08
Identities = 92/419 (21%), Positives = 186/419 (44%), Gaps = 52/419 (12%)
Query: 249 ELQSKLKDLFN-VDAFKLESLEAK------NRALNEQIARLEQ-------EREKEPNRLE 294
ELQ+++++L ++A + +A+ +R L E RLE+ + E R
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 295 SLRKLKASLQGDVQKYQAYMSNL-ESHS---AILDQKLNGLNEEIARVELECETIKQENT 350
+K++ L+ +++A + L + H+ A L ++++ L ++E E +K E
Sbjct: 1174 EFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233
Query: 351 RLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIET 410
L + ++ + A+ E++ L+ ++++ K E EQQ+L NE + K + T
Sbjct: 1234 DLASNMETVSKAKANFEKMCRT---LEDQLSEI-KTKEEEQQRLINE---LSAQKARLHT 1286
Query: 411 QLAEYHK-LARKLKLIPKGAENSKGYDFEIK-----FNPEAGANCLVKYRAQVYVPLKEL 464
+ E+ + L K ++ + + + + +I+ E A + + Q +L
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDL 1346
Query: 465 LNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRT----LKEEVQKLDDLYQQKIKE 520
L E EE +A K L+ + + N+ + + + T EE+++ Q++++
Sbjct: 1347 LREQYEEEQEA---KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQD 1403
Query: 521 AEEEDEKCASELESLEKHKHLLESTVN------QGLSEAMNELDAVQREYQLVVQTTTEE 574
AEE E S+ SLEK K L++ V + + A LD QR + V+ ++
Sbjct: 1404 AEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQK 1463
Query: 575 RRKVGNNL---QRLLEMVATHVGSVEKHLEEQIAKVD---REYEECMSE--DLSENIKE 625
+ L Q+ ++T + V+ EE + ++ RE + E DL+E I E
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAE 1522
Score = 52.8 bits (125), Expect = 1e-06
Identities = 97/499 (19%), Positives = 201/499 (40%), Gaps = 123/499 (24%)
Query: 243 FDEMNAELQS-------------KLKDLFNVDAFKLESLEAKNRALNEQIARLEQ---ER 286
++E AEL++ K+K+ + LE+L+ +N+ L ++I+ L + E
Sbjct: 1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEG 1523
Query: 287 EKEPNRLESLRKL----KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEI----ARV 338
K + LE ++K K+ LQ +++ +A + + E + +LN + EI A
Sbjct: 1524 GKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEK 1583
Query: 339 ELECETIKQENTR----LQNIIDNQKYSVADIERINHER----NELQQTINKLTKDLEAE 390
+ E + +K+ + R +Q+ +D + S D RI + NE++ +N +
Sbjct: 1584 DEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEA 1643
Query: 391 QQKLWNEE--LKYA--------RGKEAIETQLA-----------EYHKLARKLKLIPKGA 429
+ L N + LK RG++ ++ QLA E +L L+ +G
Sbjct: 1644 LRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGR 1703
Query: 430 ENSKGYDFEIKFNPE---AGANCLVKYRAQVYVPLKELLNETEEEINKALNK-------- 478
+ ++ + + L+ + ++ + ++ E E+ + +A N
Sbjct: 1704 KMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAI 1763
Query: 479 -----------------------KMGLEDTLEQLNAMITESKR-SVRTLKEEVQKLDDLY 514
K +E T++ L + E+++ +++ K+++QKL+
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1823
Query: 515 QQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEE 574
++ E E E + ++ L KH+ ++ Q TEE
Sbjct: 1824 RELESEVESEQKHNVEAVKGLRKHERRVKELTYQ-----------------------TEE 1860
Query: 575 RRKVGNNLQRLLEMVATHVGSVEKHLEE----------QIAKVDREYEECMSE-DLSEN- 622
RK LQ L++ + T V + ++ EE + K+ E EE D++E+
Sbjct: 1861 DRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQ 1920
Query: 623 IKEIRDKYEKKATLIKSSE 641
+ ++R K + T + S E
Sbjct: 1921 VNKLRVKSREVHTKVISEE 1939
Score = 39.7 bits (91), Expect = 0.009
Identities = 40/192 (20%), Positives = 88/192 (45%), Gaps = 33/192 (17%)
Query: 461 LKELLNETEEEINKALNKKMGLED----TLEQLNAMITESKRSVRTLKEEVQKLDDLYQQ 516
+KE +T+EE+ K K+ LE+ +++ N + + + L + ++ D L +
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKT 915
Query: 517 KIK---------EAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLV 567
KI+ E E++E+ +EL + ++ L + +EL + +L
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRK-----------LEDECSELKKDIDDLELT 964
Query: 568 VQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIR 627
+ +E+ N ++ L E +A L+E IAK+ +E ++ + E + + +++
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMA--------GLDETIAKLTKE-KKALQEAHQQTLDDLQ 1015
Query: 628 DKYEKKATLIKS 639
+ +K TL K+
Sbjct: 1016 MEEDKVNTLTKA 1027
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.9 bits (172), Expect = 4e-12
Identities = 94/457 (20%), Positives = 192/457 (42%), Gaps = 79/457 (17%)
Query: 241 DSFDEMNAELQSKLKDLF---NVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLR 297
D ++E L+ +L+ L + A + L+ + +L+++ L++ RE+ +LE L
Sbjct: 424 DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
Query: 298 K---------LKASLQGDVQKYQAYMSNLESHSAI-----LDQKLNGLN----------- 332
+ ++ LQGD + Q E H A+ L + L GL
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543
Query: 333 ---EEIARVELECETIKQENTRLQNIIDNQKYSVADI----ERINHERNELQQTINKLTK 385
E + LE E ++QE T + + + S+A++ + E +L+ KL+
Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603
Query: 386 -----------------DLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKG 428
LE E Q + + + + A++ LAE K L
Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREAL------ 657
Query: 429 AENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQ 488
E + + +++ EAG A++ L+++ E EE K + E Q
Sbjct: 658 WEKNTHLEAQLQKAEEAG--------AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
Query: 489 LNAMITESKRSVRTLKEEVQKLDDLYQQK------IKEAEEEDEKCASELESLEKHKHLL 542
L + E+KR L VQ+ + L ++K ++ E + + A +L+ L K LL
Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL 769
Query: 543 ESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLE- 601
ES++ + + + ++ + + ++ +QT T+ + + ++ L + T E+ +
Sbjct: 770 ESSLFEA-QQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDA 828
Query: 602 --EQIAKVDREYEECMSEDLSENIKEI---RDKYEKK 633
Q+A+ ++E + + + + + KE+ R+K+EK+
Sbjct: 829 AARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865
Score = 62.0 bits (149), Expect = 2e-09
Identities = 75/379 (19%), Positives = 158/379 (41%), Gaps = 41/379 (10%)
Query: 266 ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
E+L LN+Q+ +LE+E + +R+E+ + + +LQ D+ + + L + L+
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665
Query: 326 QKLNGLNEEIARVELECETIKQENTRLQNIID----NQKYSVADIERINHERNELQQTIN 381
+L E A ++ + I++E +Q + Q+ + +E+++ E ++ +
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725
Query: 382 KLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKF 441
+ ++ EA R K A+E +L + + L +G ++K F
Sbjct: 726 RAVQEKEA-----------LVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLF 774
Query: 442 NPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVR 501
+ + + + Q+ V ++ + E + K+ L+ Q + R +
Sbjct: 775 EAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLA 834
Query: 502 TLKEE------------VQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQG 549
++E ++++ L ++ KE ++ A LESLE+ K LE
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELE----MR 890
Query: 550 LSEAMNELDAVQREYQLVVQTTTEERRKVGNNL-QRLLEMVATHVGSVEKHLEEQ--IAK 606
L E E++A+Q + + EER + + L Q LE V +E L+ Q +A
Sbjct: 891 LKEQQTEMEAIQAQRE-------EERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 607 VDREYEECMSEDLSENIKE 625
++ E + + +KE
Sbjct: 944 ASQQLERLRQDMKVQKLKE 962
Score = 58.2 bits (139), Expect = 2e-08
Identities = 90/405 (22%), Positives = 169/405 (41%), Gaps = 63/405 (15%)
Query: 267 SLEAKNRALNEQIARLEQEREKE---PNR-----LESLRKLKASLQGDVQKYQAYMSNLE 318
SL + R L Q +L QER +E P++ LE ++ + + +V+ Q ++ L+
Sbjct: 1691 SLRERGRELTTQ-RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749
Query: 319 SHSAILDQKLNGLNEEIARVELECETIKQENTRL-QNIIDNQKYSVADIERINHERNELQ 377
L+Q+L GL+ ++ L +QE L Q + + ++ + + + +E Q
Sbjct: 1750 ELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 378 QTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDF 437
+ + + ++LEA QQ E + A+G+E ++ K + E
Sbjct: 1810 RALAQRDQELEALQQ-----EQQQAQGQE---------ERVKEKADALQGALEQ------ 1849
Query: 438 EIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESK 497
A+ +K R KE EEE+ + LE+ L L A E +
Sbjct: 1850 ---------AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQE 1900
Query: 498 RSVRTLKE-----------EVQKLDDLY---QQKIKEAEEEDEKCASELESLEKHKHLLE 543
+++ L++ E + L D + Q +KE ++E E +E +S +H+
Sbjct: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS-SRHQEEAA 1959
Query: 544 STVNQGLSEAMNELDAV--QREYQLVVQTTTEERRKVGN-NLQRLLEMVATHVGSVEKHL 600
+ L EA+ + A +E L+ Q + LQ L+ H +E+ L
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 601 ---EEQIAKVDREYEE---CMSEDLSENIKEIRDKYEKKATLIKS 639
E +I D Y+E + + L++ +E+R + E++ L KS
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Score = 56.6 bits (135), Expect = 7e-08
Identities = 74/348 (21%), Positives = 163/348 (46%), Gaps = 43/348 (12%)
Query: 250 LQSKLKDLFNVDAFKLESLEAK----NRAL---NEQIARLEQEREKEPNRLESLRKLKAS 302
LQ +L++ K +SL+++ RAL ++++ L+QE+++ + E +++ +
Sbjct: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADA 1842
Query: 303 LQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYS 362
LQG ++ QA+M+ E H + D K E+ R+E E + E R+Q + +
Sbjct: 1843 LQGALE--QAHMTLKERHGELQDHK-----EQARRLE---EELAVEGRRVQALEE----V 1888
Query: 363 VADIERINHERNE----LQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKL 418
+ D+ + E+ + LQQ + ++ E E + L + L+ A +
Sbjct: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ----------AVLKER 1938
Query: 419 ARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNK 478
++L+ + +++S+ + + EA L K A + + LL + E ++++L
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAE--LSRSLEA 1996
Query: 479 KMG-LEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEK 537
L+ +L+ A + + ++R + E+Q D YQ+ +++ ++ + EL ++
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 538 HKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRL 585
+ LLE ++ Q + E M +Q + L + EE R + +++ L
Sbjct: 2057 REQLLEKSLAQRVQENM-----IQEKQNLGQEREEEEIRGLHQSVREL 2099
Score = 55.1 bits (131), Expect = 2e-07
Identities = 76/349 (21%), Positives = 144/349 (41%), Gaps = 80/349 (22%)
Query: 267 SLEAKNRALNEQIARLEQEREKEPN--------RLESLRKLKASLQGDVQKYQAYMSNLE 318
+LE + A +++ +L ++ EKE + LESL + K L+ +++ Q M ++
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 319 SHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQ 378
+ ++ E A +++ ET K+ + L+ ++ QK E + Q
Sbjct: 903 AQ-----REEERTQAESALCQMQLETEKERVSLLETLLQTQK-----------ELADASQ 946
Query: 379 TINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFE 438
+ +L +D++ ++ LK ++TQL E R+LK E ++ +
Sbjct: 947 QLERLRQDMKVQK-------LKEQETTGILQTQLQEAQ---RELK------EAARQH--- 987
Query: 439 IKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKR 498
++ L +EE + L KM L+ +E L + +
Sbjct: 988 -----------------------RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 499 SVRTLKEEVQ-KLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLE------------ST 545
S R +++EVQ KL + + + E E EK + L +EK + LL S
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTE-ERRKVGNNLQRLLEMVATHV 593
+ Q + EA E + + +L+ Q E E + Q L E+ A+H+
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHI 1133
Score = 54.7 bits (130), Expect = 3e-07
Identities = 75/398 (18%), Positives = 164/398 (41%), Gaps = 10/398 (2%)
Query: 247 NAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGD 306
N E +SK + N +L L +L ++ R E +R + E L+ K +L
Sbjct: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
Query: 307 VQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADI 366
V+ QA + + ++ L + ++L+ E ++ E R Q + + + VA
Sbjct: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
Query: 367 ERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIP 426
+ + L QT+ + +++E + ++ E + K A+E + K +++ L
Sbjct: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
Query: 427 KGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTL 486
+ + + ++ P A V+ R Q +E + E E++ N L
Sbjct: 1477 EQIQELEKCRSVLEHLPMA-----VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Query: 487 EQLNAMITESKRSVRTLKEEVQKLD--DLYQQKIKEAEEEDEKCASELESLEKHKHLLES 544
E+ + MI + V+ LK+++ L+ L ++ E +K ELE + + + +
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
Query: 545 TVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQI 604
+ L E EL A + + +T R++ Q ++ + +++ E
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE-VKSQREQIEELQRQKEHLT 1650
Query: 605 AKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
++R +E M + E I+ + D+ ++ +++ E
Sbjct: 1651 QDLERRDQELMLQ--KERIQVLEDQRTRQTKILEEDLE 1686
Score = 53.9 bits (128), Expect = 4e-07
Identities = 87/378 (23%), Positives = 146/378 (38%), Gaps = 77/378 (20%)
Query: 275 LNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE 334
L E++ E E+ + L+ L++ + Q + K++ ++LES L + + L
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 335 IARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQ-- 392
+ R EL+ + E LQ +N V ++ E L +DL +
Sbjct: 1329 LRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSAL 1388
Query: 393 KLWNEELKYARGK-----EAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGA 447
KL NEE++ R + E E ++A+ L L L
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVAQGKALQENLAL----------------------- 1425
Query: 448 NCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEV 507
L + L E EEE+ + LE E A + ++ +EV
Sbjct: 1426 -------------LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 508 QKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLV 567
DL Q++I+E EKC S LE L + E +L VQRE
Sbjct: 1473 ----DLQQEQIQEL----EKCRSVLEHLP-----------MAVQEREQKL-TVQREQIRE 1512
Query: 568 VQTTTEERRKVGNN----LQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENI 623
++ E +R V + L++ +M+ + G V+ L++Q+ + EC++ +L EN
Sbjct: 1513 LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQ-DLKKQLVTL-----ECLALELEEN- 1565
Query: 624 KEIRDKYEKKATLIKSSE 641
K E + LIK E
Sbjct: 1566 ---HHKMECQQKLIKELE 1580
Score = 49.7 bits (117), Expect = 8e-06
Identities = 76/407 (18%), Positives = 174/407 (42%), Gaps = 54/407 (13%)
Query: 270 AKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLN 329
A+ +AL E +A L Q + +E+LR G +Q+ + ++ +L L
Sbjct: 1414 AQGKALQENLALLTQTLAEREEEVETLR-------GQIQELEKQREMQKAALELLSLDLK 1466
Query: 330 GLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEA 389
N+E V+L+ E I QE + ++++++ +V + E+ + ++ I +L KD E
Sbjct: 1467 KRNQE---VDLQQEQI-QELEKCRSVLEHLPMAVQEREQ---KLTVQREQIRELEKDRET 1519
Query: 390 EQQKLWNEELKYARGKEAIETQLAE---------------------YHKLARKLKLIPK- 427
++ L ++ L+ + + IE+Q + +HK+ + KLI +
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKEL 1579
Query: 428 --GAENSKGYDFEIKFNPEAGANCLVKYRAQVY------VPLKELLNETEEEINKALNKK 479
E + + + E + L +Q++ L L E ++E+ +
Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI 1639
Query: 480 MGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASEL----ESL 535
L+ E L + + + KE +Q L+D ++ K EE+ E+ L L
Sbjct: 1640 EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGREL 1699
Query: 536 EKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEE---RRKVGNNLQRLLEMVATH 592
+ L++ +G + + +++ +L+++ +E +++ + LQ L + +
Sbjct: 1700 TTQRQLMQERAEEGKGPSKAQRGSLE-HMKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758
Query: 593 VGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKS 639
+ + + + E + + +E + L + ++E R++ E K ++S
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVV--LQQQLQEAREQGELKEQSLQS 1803
Score = 48.5 bits (114), Expect = 2e-05
Identities = 69/352 (19%), Positives = 143/352 (40%), Gaps = 49/352 (13%)
Query: 275 LNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE 334
L +Q + E+E + RL+ L + +L G Q + +L +L + L ++
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ 478
Query: 335 IARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKL 394
+ +E E +++ N LQ D+ + + + H ++ + ++ LEA+Q +
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538
Query: 395 WNEEL-------------------------KYARGKEAI----------ETQLAEYHKLA 419
+E + AR +++I +T++A+ A
Sbjct: 539 LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAA 598
Query: 420 RKLKLIPKG-AENSKGYDFEIKFNPEAGANCLVKYRA--QVYVPLKELLNETEEEINKAL 476
KL + + A + G + ++ E + + A Q L+ L E E+
Sbjct: 599 VKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALW 658
Query: 477 NKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLE 536
K LE L++ E + +R ++EE +++ Q+K+ E+ + E ++LE L
Sbjct: 659 EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI----QKKLSESRHQQEAATTQLEQLH 714
Query: 537 KHKHLLESTVNQGLSEAMNELDAVQRE---YQLVVQTTTEERRKVGNNLQRL 585
+ E L+ A+ E +A+ RE ++ +Q +R+ + LQ L
Sbjct: 715 QEAKRQEEV----LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Score = 43.9 bits (102), Expect = 5e-04
Identities = 95/464 (20%), Positives = 191/464 (41%), Gaps = 59/464 (12%)
Query: 213 EETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKN 272
E+ GI+ +L + + E+ D + E S L+D ++ ++E L+++
Sbjct: 962 EQETTGILQTQL-QEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK-QVEDLKSQL 1019
Query: 273 RALNEQIARLEQEREK------EPNRLES-LRKLKASLQGDVQKYQAYMSNLESHSAILD 325
A ++ +EQE ++ E NR++ L + KASL + + + + L+ +I
Sbjct: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
Query: 326 QKLNGLNEEIARVELECETIKQENTRL-QNIIDNQKYSVADIERINHERNELQQTINKLT 384
Q+L+ L +++ + E + + + L Q + + + +A ++ E T +L
Sbjct: 1080 QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
Query: 385 KDLEAEQQKLWNEELKYARGKEAIETQLAE----------------YHKLARKLKLIPKG 428
L A++ K +L+ + +E AE Y L + L + +
Sbjct: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCES 1199
Query: 429 A-ENSKGYDFEIK---FNPEA-GANCLVKYRAQVYVPLK-----ELLNETEEEINKALNK 478
E S G D P+ GA L K R + L L++ +++ K
Sbjct: 1200 RPELSGGGDSAPSVWGLEPDQNGARSLFK-RGPLLTALSAEAVASALHKLHQDLWKTQQT 1258
Query: 479 KMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKH 538
+ L D +++L +T+++ + E+Q L Q+++ + +EE K + SLE
Sbjct: 1259 RDVLRDQVQKLEERLTDTEAEKSQVHTELQDL----QRQLSQNQEEKSKWEGKQNSLE-- 1312
Query: 539 KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEK 598
L+E L E M L + R +L +R + LL+ ++ + +
Sbjct: 1313 SELME------LHETMASLQSRLRRAEL--------QRMEAQGERELLQAAKENLTAQVE 1358
Query: 599 HLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
HL Q A V+ + + L E+++ R + K ++S E
Sbjct: 1359 HL--QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
Score = 39.3 bits (90), Expect = 0.011
Identities = 81/382 (21%), Positives = 156/382 (40%), Gaps = 98/382 (25%)
Query: 275 LNEQIARLEQEREKEPNRLESLRKLKASLQGD------VQKYQAYMSNLESHSAILDQKL 328
L EQ+ L+Q+ + N+ S RKLK S + V+K QA + S L+++L
Sbjct: 20 LEEQVLALQQQMAE--NQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL 77
Query: 329 NG----------------LNEEIARVELE---CETIKQENTRLQNIIDN----QKYSVAD 365
L+E + R+E E CE++ + NT+L+ ++ K D
Sbjct: 78 EATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRED 137
Query: 366 IERINHERNELQQTINKLTKDLEAEQQ--------------KLWNE---------ELKYA 402
+E++ + + + + + + EQ+ LW E E+K A
Sbjct: 138 VEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSA 197
Query: 403 RGKEAIETQLAEYHKLARKLKL----IPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVY 458
++ +E + AE+ +L+ L + GA++ + P + AQ+
Sbjct: 198 TDRDLMELK-AEHVRLSGSLLTCCLRLTVGAQSRE---------PNGSGRMDGREPAQLL 247
Query: 459 VPL---KELLNETEEEINKALN-------KKMGLEDTLEQLNAMITESKRSVRTLKEEVQ 508
+ L +EL E E + + +K L+D + +L+A++T+S Q
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQS-----------Q 296
Query: 509 KLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVV 568
K ++ Y++ IK E E + L +H E+++++ E L V ++ +
Sbjct: 297 KQNEDYEKMIKALRETVEILETNHTELMEH----EASLSRNAQEEKLSLQQVIKD---IT 349
Query: 569 QTTTEERRKV--GNNLQRLLEM 588
Q EE + G+ + LE+
Sbjct: 350 QVMVEEGDNIAQGSGHENSLEL 371
Score = 39.3 bits (90), Expect = 0.011
Identities = 76/371 (20%), Positives = 146/371 (39%), Gaps = 28/371 (7%)
Query: 241 DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLE-QEREKEPNRLESLRKL 299
++ + +A LQ K + L A SLEA L + + R+ E E+LR
Sbjct: 1968 EALGKAHAALQGKEQHLLE-QAELSRSLEASTATLQASLDACQAHSRQLE----EALRIQ 2022
Query: 300 KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQ 359
+ +Q +YQ + L+ A D++L E +E QEN + Q
Sbjct: 2023 EGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ 2082
Query: 360 KYSVADIERINHERNELQQTINKLTK---DLEAEQQKLWNEELKYARGKEAIETQLAEYH 416
+ +I ++ ELQ T+ + + +L QQ+ E L ++ +E Q +
Sbjct: 2083 EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLD 2142
Query: 417 ----KLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEI 472
+L R+L+ + ++ + E + + A L + +A V L+E+ + +
Sbjct: 2143 SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASV-SSLQEVAMFLQASV 2201
Query: 473 NKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASEL 532
+ +++ L+D LE L E +R +L +Q ++ E +
Sbjct: 2202 LERDSEQQRLQDELE-LTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSP 2260
Query: 533 ESLEKH------KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLL 586
+ +EK +HL ++ + + + VQ + ++ ERRK+ R
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ--LRSTLEQVERERRKLKREAMR-- 2316
Query: 587 EMVATHVGSVE 597
A GS+E
Sbjct: 2317 ---AAQAGSLE 2324
Score = 30.8 bits (68), Expect = 4.0
Identities = 51/275 (18%), Positives = 106/275 (38%), Gaps = 11/275 (4%)
Query: 266 ESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
E E + R L++ + L+ ++ + LR+ + + + S +E S LD
Sbjct: 2083 EREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLD 2142
Query: 326 QKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTK 385
L E+ R++ + + + S+A + E+ +
Sbjct: 2143 SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL 2202
Query: 386 DLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSK-GYDFEIKFNPE 444
+ ++EQQ+L +EL+ R A+E + +L +G + + G ++ P
Sbjct: 2203 ERDSEQQRL-QDELELTR--RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPS 2259
Query: 445 AGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQL----NAMITESKRSV 500
+R Q L++ + E + ++ + L TLEQ+ + E+ R+
Sbjct: 2260 PDGMEKQSWR-QRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAA 2318
Query: 501 RTLKEEVQK--LDDLYQQKIKEAEEEDEKCASELE 533
+ E+ K QQ + + D KC +EL+
Sbjct: 2319 QAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQ 2353
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 70.5 bits (171), Expect = 5e-12
Identities = 98/443 (22%), Positives = 176/443 (39%), Gaps = 75/443 (16%)
Query: 264 KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAI 323
++ L ++N ++ Q+ + E + +E R+ SL QK A E
Sbjct: 703 QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762
Query: 324 LDQKLNGLNEEIARVELECETIKQENTRLQNI---IDNQKYSVADIERINHERNELQQTI 380
+ Q L G NE++A E+ E +K+E L+ + Q+ S+ +R + QTI
Sbjct: 763 MTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822
Query: 381 NKLTKDLEAE-QQKLWNE----ELKYARGKEAIETQLAEYHKLARKL------------- 422
+ + E E +Q+L ++ E + + K+ +E ++ + H L R L
Sbjct: 823 QGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT 882
Query: 423 --KLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYV--------------PLKELLN 466
L E K EI + +N V+ +Q L L
Sbjct: 883 ETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 467 ETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDE 526
+TEE++N + +EQ AM+T + S+ K+ +++ + ++KE+ E
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQT 1002
Query: 527 KCASELESLEKHKHLLE-------STVNQGLSEAMNELDAVQREYQLVVQTTT------- 572
+ +L +EK K L+ ++ Q LSE L +VQ E Q +Q +
Sbjct: 1003 QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
Query: 573 ------EERRKVG----NNLQRLLEMVATHV-------------GSVEKHLEEQIAKVDR 609
+E+ K+ N +R L + A V SV +HLEE K +
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
Query: 610 EYEECMSEDLSENIKEIRDKYEK 632
+ EC + E + ++D+ K
Sbjct: 1123 QLLECKA-SWEERERMLKDEVSK 1144
Score = 59.7 bits (143), Expect = 8e-09
Identities = 97/454 (21%), Positives = 183/454 (40%), Gaps = 87/454 (19%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIAR--------------------LEQEREK 288
E + LKD + + E LE +NR L++QI + L +E +
Sbjct: 1133 ERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192
Query: 289 EPNRLESLRKLK-----ASLQGDVQKYQA--YMSNLESHSAILDQKLNGLNEEIARVELE 341
+ LE LR ++ A + +V + ++ Y +E L + + LN E +V++
Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252
Query: 342 CETIKQ-----ENTRLQNII-DNQKYSVADIERINHERNELQQTINKLTKDL----EAE- 390
+T+ Q + T N++ + K + ER+ + ++Q + KL D+ EA
Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA 1312
Query: 391 -----------QQKLWNEELK--YARGKEAIETQ----LAEYHKLARKLKLIPKGAENSK 433
++KL E++K AR + + Q EY KL + ++ K +
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLT 1372
Query: 434 GYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMI 493
+K L + L+ +E++NK +K E + L+A I
Sbjct: 1373 EEIGRLKAEIARSNASLTNN--------QNLIQSLKEDLNKVRTEK---ETIQKDLDAKI 1421
Query: 494 TESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEK-----CASELESLEKHKHLLESTVNQ 548
+ + V+T+ +V+K+ Y+ + +E + + +K S + E+H + E Q
Sbjct: 1422 IDIQEKVKTI-TQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEM---Q 1477
Query: 549 GLSEAMNELDAVQREYQLVV---QTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIA 605
L E +N+ + + + V Q T E+ NLQ + + + + + L+
Sbjct: 1478 ELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQ---- 1533
Query: 606 KVDREYEECMSEDLSENIKEIRDKYEKKATLIKS 639
DR +E E L + I E +K K KS
Sbjct: 1534 --DRTTQE---EQLRQQITEKEEKTRKAIVAAKS 1562
Score = 57.0 bits (136), Expect = 5e-08
Identities = 80/450 (17%), Positives = 183/450 (40%), Gaps = 73/450 (16%)
Query: 240 ADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKL 299
+ +++ E+ K L N ++E R L+ Q+ +++ + E N + ++L
Sbjct: 838 SSQIEKLEHEISHLKKKLEN----EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL 893
Query: 300 KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELE--CETIKQENTRLQNIID 357
+ Q ++ + ++SN+E A + G + + +++ ++Q ++ ++ +
Sbjct: 894 LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE 953
Query: 358 NQKYSVADIER-----------INHERN-----------------ELQQTINKLTKDLEA 389
K S +++E+ +N E+ E Q + K ++E
Sbjct: 954 RLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEK 1013
Query: 390 EQQKLWNEELKYARGKEAIETQLAEYHK--------LARKLKLIPKGAENSKGYDFEIKF 441
E+Q+L +++ R E++E QL+E K + L+ N + + +
Sbjct: 1014 EKQELQDDK---RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
Query: 442 NPEAGANCLVKYRAQVYVPLK--ELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRS 499
+ KY ++ + E L +E+++K + + LE+T ++ + + E K S
Sbjct: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKAS 1130
Query: 500 VRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDA 559
++++ + ++E KC E LEK LL + + LS+ + + +
Sbjct: 1131 --------------WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEK-LSDKV--VAS 1173
Query: 560 VQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVD----REYEECM 615
V+ Q + + E K + +L + E E +A+V+ R+ E +
Sbjct: 1174 VKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFE--VAQVESLRYRQRVELL 1231
Query: 616 SEDLSE---NIKEIRDKYEKKATLIKSSEE 642
+L E ++ R+K + A + EE
Sbjct: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEE 1261
Score = 48.5 bits (114), Expect = 2e-05
Identities = 82/427 (19%), Positives = 173/427 (40%), Gaps = 62/427 (14%)
Query: 264 KLESLEAKNRALNEQIARLEQERE-----------KEPNRLESLRKLKASLQGDVQKYQA 312
KL+ L+A + ++ + RLEQE+E + + + L L ++ + +
Sbjct: 165 KLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC 224
Query: 313 YMSNLESHSAILDQKLNGLNEEIARVELECETI-------KQENTRLQNIIDNQ------ 359
+ N + + L++++NGL ++ E + K++ ++ N+
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 360 -----KYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAE 414
K + D E ++E + ++KL K+ + + + L+ + K+ +E ++ E
Sbjct: 285 LSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE 344
Query: 415 YHKLARKLKLIPK-----GAENSKGYDFE----IKFNPEAGANCLVKYRAQVYVPLKELL 465
K+ R K + A KG +P A A + L
Sbjct: 345 --KIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAY 402
Query: 466 NETEEEI------NKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIK 519
ET++++ NK +NK L++ ++++ A KR R E QK K++
Sbjct: 403 VETQDQLLLEKLENKRINKY--LDEIVKEVEAKAPILKRQ-REEYERAQKAVASLSVKLE 459
Query: 520 EAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVG 579
+A +E ++ + + K +LE N+ + + +L R V+ EE R G
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLERD-NRRMEIQVKDLSQQIR----VLLMELEEAR--G 512
Query: 580 NNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSED-----LSENIKEIRDKYEKKA 634
N++ R E+ + + S + + + + R EE ++ + E R++ E++
Sbjct: 513 NHVIRDEEVSSADISSSSEVISQHLVSY-RNIEELQQQNQRLLVALRELGETREREEQET 571
Query: 635 TLIKSSE 641
T K +E
Sbjct: 572 TSSKITE 578
Score = 45.1 bits (105), Expect = 2e-04
Identities = 65/285 (22%), Positives = 122/285 (42%), Gaps = 17/285 (5%)
Query: 372 ERNELQQTI-NKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHK-LARKLKLIPKGA 429
E N+L +++ NKL K L +Q ++ + ++ + K E Q E K L+ + +
Sbjct: 13 ELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNET 72
Query: 430 ENSKGYDFEI-KFNPEAGA----NCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLED 484
+ E+ K N + A N ++ + ++ T+EE+ + +
Sbjct: 73 RECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNE 132
Query: 485 TLEQLNAMITES-KRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLE 543
L Q +TE KR LKE +L Q K+ E + D + LE+ K LL
Sbjct: 133 RLSQELEYLTEDVKRLNEKLKESNTTKGEL-QLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 544 ST---VNQGLSEAMNELDAVQREYQ---LVVQTTTEERRKVGNNLQRLLEMVATHVGSVE 597
S +N L +EL A+ RE L ++ E +++ + L+ + + T ++
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
Query: 598 KHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
KH+E+ + K+ E+ S + E + + K + L KS+ +
Sbjct: 252 KHVEDLLTKLKEAKEQQAS--MEEKFHNELNAHIKLSNLYKSAAD 294
Score = 43.1 bits (100), Expect = 8e-04
Identities = 82/396 (20%), Positives = 161/396 (40%), Gaps = 43/396 (10%)
Query: 264 KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAI 323
+LE L + +AL E+ LE +++ + K L+ + + +L +
Sbjct: 81 ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKR-------DLIRTNER 133
Query: 324 LDQKLNGLNEEIARVELECETIKQENT---RLQNIIDNQKYSVADI----ERINHERNEL 376
L Q+L L E++ R+ E +K+ NT LQ +D + S + +R+ E+ L
Sbjct: 134 LSQELEYLTEDVKRLN---EKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELL 190
Query: 377 QQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYD 436
L +L+ + +L L +G E +E + L K + + + E G
Sbjct: 191 HSQNTWLNTELKTKTDELL--ALGREKGNEILELKC----NLENKKEEVSRLEEQMNGLK 244
Query: 437 FEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLE-------DTLEQL 489
+ + + L K + KE EE+ + LN + L D E
Sbjct: 245 TSNEHLQKHVEDLLTKLK-----EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAK 299
Query: 490 NAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVN-Q 548
+ +T + + L +E + + Q + E E+ ++ E E LEK L + N
Sbjct: 300 SNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ--MEKEMLEKIGRLEKELENAN 357
Query: 549 GLSEAMNELDAVQREYQLVVQTTTEER-RKVGNNLQRLLEMVATHVGSVEKHLEEQI--A 605
L A A+ E +L + T K+ +L E+ +V + ++ L E++
Sbjct: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK 417
Query: 606 KVDREYEECMSEDLSEN--IKEIRDKYEKKATLIKS 639
++++ +E + E ++ +K R++YE+ + S
Sbjct: 418 RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVAS 453
Score = 32.0 bits (71), Expect = 1.8
Identities = 37/170 (21%), Positives = 76/170 (44%), Gaps = 23/170 (13%)
Query: 238 SGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLR 297
SG ++ + +LK+ N K +SLE++ L + ++ E E + L+
Sbjct: 1463 SGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQ 1522
Query: 298 KLKASLQGDVQ---------KYQAYMSNLESHSAILDQK-----LNGLNEEIARVELECE 343
+ L+ D+Q + Q ++ AI+ K L G+ +++ + E E
Sbjct: 1523 SELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK---ENE 1579
Query: 344 TIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQK 393
+KQ N +D QK + D+ RI +++ + I++L ++L Q++
Sbjct: 1580 ELKQRN----GALDQQKDEL-DV-RITALKSQYEGRISRLERELREHQER 1623
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 70.1 bits (170), Expect = 6e-12
Identities = 89/422 (21%), Positives = 180/422 (42%), Gaps = 49/422 (11%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQ 308
E++ L D +L ++ K +N++ +++ + E LE+ + + +
Sbjct: 854 EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA 913
Query: 309 KYQAYMSNL--------ESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
+++A MS+L +S++ IL G EEI + E + K+E +Q I K
Sbjct: 914 EHEAKMSSLSQSMRKVQDSNAEILANYRKG-QEEIVTLHAEIKAQKKELDTIQECI---K 969
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
A I + + T +L L + QK Y+ +E ++ E KL +
Sbjct: 970 VKYAPIVSFEECERKFKATEKELKDQLSEQTQK-------YSVSEEEVKKNKQENDKLKK 1022
Query: 421 KLKLIPKGAENS-----KGYDFEIKFNPEAGA-NCLVKYRAQVYVPLKELLNETEEEINK 474
++ + K + K ++ E + + N +K +Q Y +K + + EE K
Sbjct: 1023 EIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1082
Query: 475 ALNKKMGLEDTL-------EQLNAMITESKRSVRTLKEEVQKLDDLYQQ------KIKEA 521
++ + +++ L EQ+ A+ ++ LKEE++ + Y++ K+ +
Sbjct: 1083 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1142
Query: 522 EEEDEKCASEL-------ESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEE 574
E + + L E+ EK ++++++ + E+ N+++ V + Q VQ T +
Sbjct: 1143 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK-LQSEVQNTKQA 1201
Query: 575 RRKVGNNLQRLLEMVATHVGSVEKH---LEEQIAKVDREYEECMSEDLSENIKEIRDKYE 631
+K+ L +E L E++A ++R+YEE E L KEI K E
Sbjct: 1202 LKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDE 1261
Query: 632 KK 633
K+
Sbjct: 1262 KE 1263
Score = 66.6 bits (161), Expect = 7e-11
Identities = 81/418 (19%), Positives = 182/418 (43%), Gaps = 54/418 (12%)
Query: 242 SFDEMNAELQSKLKDL---FNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRK 298
S D + +L KL D+ + ++E L +N +L++ ++RLE
Sbjct: 743 SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE--------------- 787
Query: 299 LKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDN 358
++ +K++ + L+S+ L ++L+ L ++ + + + ENT L+ ++ N
Sbjct: 788 ---TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 844
Query: 359 QKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL------ 412
Q V E + N+ N+ D++ + + + E +K E ++ L
Sbjct: 845 QYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQ 904
Query: 413 --AEYHKLAR---KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNE 467
AEY LA K+ + + + + EI N G +V A++ KEL
Sbjct: 905 IKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL--- 961
Query: 468 TEEEINKALNKKMGLEDTLEQLNAMITESKRSVR-TLKEEVQKLDDLYQQKIKEAEEEDE 526
+ I + + K + E+ +++ ++ L E+ QK + ++++K+ ++E++
Sbjct: 962 --DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKY-SVSEEEVKKNKQEND 1018
Query: 527 KCASELESLEK----------HKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERR 576
K E+ +L+K H +E +++ E +L + ++Y + + +
Sbjct: 1019 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKY---TEVKNVKEK 1075
Query: 577 KVGNNLQRLLEMVATHVGSVEKHLE-EQIAKVDREYEECMSEDLSENIKEIRDKYEKK 633
V N ++ E++A ++H+ EQ+ + + + E+L E +K ++ YEK+
Sbjct: 1076 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI-ENLKEELKSMQRCYEKE 1132
Score = 63.9 bits (154), Expect = 4e-10
Identities = 90/449 (20%), Positives = 190/449 (42%), Gaps = 69/449 (15%)
Query: 227 DYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDA------------------FKLESL 268
D + ++ G + ++AE++++ K+L + FK
Sbjct: 931 DSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEK 990
Query: 269 EAKNRALNEQIARL---EQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
E K++ L+EQ + E+E +K + L+K +LQ D++ + L
Sbjct: 991 ELKDQ-LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1049
Query: 326 QKLNGLNEEI-------ARVELECETIKQENTR-------LQNIIDNQKYSVADIERINH 371
+K + LN+++ V+ E + +EN + +QN++ Q + +E +
Sbjct: 1050 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL-- 1107
Query: 372 ERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQ------LAEYHKLAR----- 420
+ L TI L ++L++ Q+ E+ + + +E Q LAE+ ++
Sbjct: 1108 -KKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKE 1166
Query: 421 ----KLKLIPKGAENSKGYDFEIKFNPEA--GANCLVKYRAQVYVPL---KELLNETEEE 471
K L K E+ + K E L K + V L K ++ E +
Sbjct: 1167 VGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ 1226
Query: 472 INKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASE 531
I+ K L E++ + +K+ + K+E + L +Q+IK+ +E +K +
Sbjct: 1227 ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1286
Query: 532 LESLEKH----KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLE 587
+ L++ +E+ N+ ++E +N+++ +++ + Q T GN +R +
Sbjct: 1287 ITELQRRIQESAKQIEAKDNK-ITELLNDVERLKQALNGLSQLTYTS----GNPTKRQSQ 1341
Query: 588 MVATHVGSVEKHLEEQIAKVDREYEECMS 616
++ T V K LE+Q+A DR+++E ++
Sbjct: 1342 LIDTLQHQV-KSLEQQLADADRQHQEVIA 1369
Score = 50.4 bits (119), Expect = 5e-06
Identities = 91/460 (19%), Positives = 188/460 (40%), Gaps = 98/460 (21%)
Query: 259 NVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGD------------ 306
N + + LE++ L +A E++ E+ +E+L+ + D
Sbjct: 319 NEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRK 378
Query: 307 ----VQKYQAYMSN-----------LESHSAI------LDQKLNGLNEEIARVELE---- 341
+++ Q YM++ ++S S + L + + EI + ELE
Sbjct: 379 EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRT 438
Query: 342 -CETIKQENTRLQNIIDNQ----KYSVADIERINHERNE----LQQTINKLTKDLEAEQQ 392
CE+ KQ+ +LQN + ++ K + ER+ + +E L+ + + K + +
Sbjct: 439 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 498
Query: 393 KLWNEELKYARGKEAIETQLAE-YHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV 451
K+ + + KE + ++ A H+L +LK + D ++K+ GA+ V
Sbjct: 499 KVKQMQTHFLALKEHLTSEAASGNHRLTEELK--------DQLKDLKVKYE---GASAEV 547
Query: 452 -KYRAQVYVPLKELLNETEE-------EINKALNKKMGL-EDTLEQLNAMITESKRSVRT 502
K R Q + E++ E + E NK L K++ + E E+ +TE + +
Sbjct: 548 GKLRNQ--IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKE 605
Query: 503 LKEEV------QKLDDLYQ----------QKIKEAEEEDEKCASELESLEKHKHLLES-- 544
L ++ +K +++ +K+ E E E EK SE+ L++ +++
Sbjct: 606 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 665
Query: 545 ----------TVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVG 594
V L + EL E L QT +E KV + + L E
Sbjct: 666 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 725
Query: 595 SVEKH-LEEQIAKVDREYEECMSEDLSENIKEIRDKYEKK 633
++ H + ++++ ++ + + +DL+ + ++ KY +K
Sbjct: 726 EMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEK 765
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 70.1 bits (170), Expect = 6e-12
Identities = 89/422 (21%), Positives = 180/422 (42%), Gaps = 49/422 (11%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQ 308
E++ L D +L ++ K +N++ +++ + E LE+ + + +
Sbjct: 867 EVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLA 926
Query: 309 KYQAYMSNL--------ESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK 360
+++A MS+L +S++ IL G EEI + E + K+E +Q I K
Sbjct: 927 EHEAKMSSLSQSMRKVQDSNAEILANYRKG-QEEIVTLHAEIKAQKKELDTIQECI---K 982
Query: 361 YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR 420
A I + + T +L L + QK Y+ +E ++ E KL +
Sbjct: 983 VKYAPIVSFEECERKFKATEKELKDQLSEQTQK-------YSVSEEEVKKNKQENDKLKK 1035
Query: 421 KLKLIPKGAENS-----KGYDFEIKFNPEAGA-NCLVKYRAQVYVPLKELLNETEEEINK 474
++ + K + K ++ E + + N +K +Q Y +K + + EE K
Sbjct: 1036 EIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1095
Query: 475 ALNKKMGLEDTL-------EQLNAMITESKRSVRTLKEEVQKLDDLYQQ------KIKEA 521
++ + +++ L EQ+ A+ ++ LKEE++ + Y++ K+ +
Sbjct: 1096 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQL 1155
Query: 522 EEEDEKCASEL-------ESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEE 574
E + + L E+ EK ++++++ + E+ N+++ V + Q VQ T +
Sbjct: 1156 LENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSK-LQSEVQNTKQA 1214
Query: 575 RRKVGNNLQRLLEMVATHVGSVEKH---LEEQIAKVDREYEECMSEDLSENIKEIRDKYE 631
+K+ L +E L E++A ++R+YEE E L KEI K E
Sbjct: 1215 LKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDE 1274
Query: 632 KK 633
K+
Sbjct: 1275 KE 1276
Score = 66.6 bits (161), Expect = 7e-11
Identities = 81/418 (19%), Positives = 182/418 (43%), Gaps = 54/418 (12%)
Query: 242 SFDEMNAELQSKLKDL---FNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRK 298
S D + +L KL D+ + ++E L +N +L++ ++RLE
Sbjct: 756 SHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE--------------- 800
Query: 299 LKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDN 358
++ +K++ + L+S+ L ++L+ L ++ + + + ENT L+ ++ N
Sbjct: 801 ---TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 857
Query: 359 QKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL------ 412
Q V E + N+ N+ D++ + + + E +K E ++ L
Sbjct: 858 QYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQ 917
Query: 413 --AEYHKLAR---KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNE 467
AEY LA K+ + + + + EI N G +V A++ KEL
Sbjct: 918 IKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKEL--- 974
Query: 468 TEEEINKALNKKMGLEDTLEQLNAMITESKRSVR-TLKEEVQKLDDLYQQKIKEAEEEDE 526
+ I + + K + E+ +++ ++ L E+ QK + ++++K+ ++E++
Sbjct: 975 --DTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKY-SVSEEEVKKNKQEND 1031
Query: 527 KCASELESLEK----------HKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERR 576
K E+ +L+K H +E +++ E +L + ++Y + + +
Sbjct: 1032 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKY---TEVKNVKEK 1088
Query: 577 KVGNNLQRLLEMVATHVGSVEKHLE-EQIAKVDREYEECMSEDLSENIKEIRDKYEKK 633
V N ++ E++A ++H+ EQ+ + + + E+L E +K ++ YEK+
Sbjct: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI-ENLKEELKSMQRCYEKE 1145
Score = 63.9 bits (154), Expect = 4e-10
Identities = 90/449 (20%), Positives = 190/449 (42%), Gaps = 69/449 (15%)
Query: 227 DYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDA------------------FKLESL 268
D + ++ G + ++AE++++ K+L + FK
Sbjct: 944 DSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEK 1003
Query: 269 EAKNRALNEQIARL---EQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILD 325
E K++ L+EQ + E+E +K + L+K +LQ D++ + L
Sbjct: 1004 ELKDQ-LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS 1062
Query: 326 QKLNGLNEEI-------ARVELECETIKQENTR-------LQNIIDNQKYSVADIERINH 371
+K + LN+++ V+ E + +EN + +QN++ Q + +E +
Sbjct: 1063 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL-- 1120
Query: 372 ERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQ------LAEYHKLAR----- 420
+ L TI L ++L++ Q+ E+ + + +E Q LAE+ ++
Sbjct: 1121 -KKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKE 1179
Query: 421 ----KLKLIPKGAENSKGYDFEIKFNPEA--GANCLVKYRAQVYVPL---KELLNETEEE 471
K L K E+ + K E L K + V L K ++ E +
Sbjct: 1180 VGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ 1239
Query: 472 INKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASE 531
I+ K L E++ + +K+ + K+E + L +Q+IK+ +E +K +
Sbjct: 1240 ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 532 LESLEKH----KHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLE 587
+ L++ +E+ N+ ++E +N+++ +++ + Q T GN +R +
Sbjct: 1300 ITELQRRIQESAKQIEAKDNK-ITELLNDVERLKQALNGLSQLTYTS----GNPTKRQSQ 1354
Query: 588 MVATHVGSVEKHLEEQIAKVDREYEECMS 616
++ T V K LE+Q+A DR+++E ++
Sbjct: 1355 LIDTLQHQV-KSLEQQLADADRQHQEVIA 1382
Score = 50.4 bits (119), Expect = 5e-06
Identities = 91/460 (19%), Positives = 188/460 (40%), Gaps = 98/460 (21%)
Query: 259 NVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGD------------ 306
N + + LE++ L +A E++ E+ +E+L+ + D
Sbjct: 332 NEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRK 391
Query: 307 ----VQKYQAYMSN-----------LESHSAI------LDQKLNGLNEEIARVELE---- 341
+++ Q YM++ ++S S + L + + EI + ELE
Sbjct: 392 EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRT 451
Query: 342 -CETIKQENTRLQNIIDNQ----KYSVADIERINHERNE----LQQTINKLTKDLEAEQQ 392
CE+ KQ+ +LQN + ++ K + ER+ + +E L+ + + K + +
Sbjct: 452 FCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 511
Query: 393 KLWNEELKYARGKEAIETQLAE-YHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLV 451
K+ + + KE + ++ A H+L +LK + D ++K+ GA+ V
Sbjct: 512 KVKQMQTHFLALKEHLTSEAASGNHRLTEELK--------DQLKDLKVKYE---GASAEV 560
Query: 452 -KYRAQVYVPLKELLNETEE-------EINKALNKKMGL-EDTLEQLNAMITESKRSVRT 502
K R Q + E++ E + E NK L K++ + E E+ +TE + +
Sbjct: 561 GKLRNQ--IKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKE 618
Query: 503 LKEEV------QKLDDLYQ----------QKIKEAEEEDEKCASELESLEKHKHLLES-- 544
L ++ +K +++ +K+ E E E EK SE+ L++ +++
Sbjct: 619 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 678
Query: 545 ----------TVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVG 594
V L + EL E L QT +E KV + + L E
Sbjct: 679 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Query: 595 SVEKH-LEEQIAKVDREYEECMSEDLSENIKEIRDKYEKK 633
++ H + ++++ ++ + + +DL+ + ++ KY +K
Sbjct: 739 EMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEK 778
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 70.1 bits (170), Expect = 6e-12
Identities = 86/425 (20%), Positives = 186/425 (43%), Gaps = 59/425 (13%)
Query: 264 KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAI 323
++E + + + EQ+ R Q+ ++ LE+ R+ ++L +Q+ S H
Sbjct: 514 EVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQS 573
Query: 324 LDQK----LNGLNEEIARVELECETIKQENTR----LQNIIDNQKYSVADIERINHERNE 375
+ QK L +E+ ++ +E E +++E LQ ++ + S D ++ + E
Sbjct: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
Query: 376 LQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYH--------------KLARK 421
L +T +L K+L+AE+Q ++E+ +E QLA +L +
Sbjct: 634 LLRTQEEL-KELQAERQ---SQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKT 689
Query: 422 LKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMG 481
L+ + + E + + K EA A L + RA V L+E T+EE ++ + +G
Sbjct: 690 LQQLRQDCEEAS----KAKMVAEAEATVLGQRRAAVETTLRE----TQEENDEFRRRILG 741
Query: 482 LEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQ---KIKEAEEEDEKCASELESLEKH 538
LE L++ ++ + L++++Q+L+ QQ + ++EE+ A+ +LE
Sbjct: 742 LEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEAR 801
Query: 539 KHLL----------ESTVNQGLSE----------AMNELDAVQREYQLVVQTTTEERRKV 578
+ T+N+ L E EL+ +R V +E K+
Sbjct: 802 LEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKI 861
Query: 579 GNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMS--EDLSENIKEIRDKYEKKATL 636
G + ++ L+ + + ++ ++A R+ ++ S E S + ++D+ ++
Sbjct: 862 GEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQA 921
Query: 637 IKSSE 641
+++S+
Sbjct: 922 LQASQ 926
Score = 63.5 bits (153), Expect = 6e-10
Identities = 75/346 (21%), Positives = 146/346 (42%), Gaps = 33/346 (9%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQ 304
E L + D N + K+ E +AL + A+LE +EK + ++
Sbjct: 841 EEQKRLLDRTVDRLNKELEKIG--EDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWA 898
Query: 305 GDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVA 364
+ +K +S L+ L Q L E L+ E + Q L+ +N+K S
Sbjct: 899 SEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQD 958
Query: 365 D-----------IERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLA 413
D + R+ E +E + T+ LT + + ++ + + + A +
Sbjct: 959 DRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLEC 1018
Query: 414 EYHKLARKLKLIPKGAENSKGYDF-EIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEI 472
+ L R+ K + +S+G+ + N L++ R Q K +L T ++
Sbjct: 1019 DKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKL 1078
Query: 473 NKAL--------NKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDL---YQQKIKEA 521
+ + +++ + D +QL+ + KR V +EE+++LD L Q++++E
Sbjct: 1079 ERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQ 1138
Query: 522 EEEDEKCASELESLEK------HKHLLESTV-NQGLSEAMNELDAV 560
E +E+ + ++SLEK + ES + N+GLS + E D+V
Sbjct: 1139 HEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLS-SDEEFDSV 1183
Score = 61.6 bits (148), Expect = 2e-09
Identities = 88/412 (21%), Positives = 183/412 (44%), Gaps = 61/412 (14%)
Query: 241 DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQI-------ARLEQEREKEPNRL 293
D + AE Q +L++ N + SL A RAL ++ ARL QE++ L
Sbjct: 765 DKLQRLEAEKQ-QLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL 823
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARV-ELECETIKQENTRL 352
E K + L+ + LE +LD+ ++ LN+E+ ++ E + ++Q +L
Sbjct: 824 EEEGKQREVLRRG-------KAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL 876
Query: 353 QNIIDNQKYSVADIERINHE-RNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQ 411
++ + + VAD +R + +E ++T L++ L+ E Q+L + L+ ++ + +T
Sbjct: 877 EDYKEKARREVADAQRQAKDWASEAEKTSGGLSR-LQDEIQRL-RQALQASQAER--DTA 932
Query: 412 LAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEE 471
+ LA++L+ + + AEN K + RA+ L+E ++ E E
Sbjct: 933 RLDKELLAQRLQGLEQEAENKKRSQDD---------------RARQLKGLEEKVSRLETE 977
Query: 472 INKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASE 531
+++ N T+E L + + V L+ E L Q++ + E +K + E
Sbjct: 978 LDEEKN-------TVELLTDRVNRGRDQVDQLRTE------LMQERSARQDLECDKISLE 1024
Query: 532 LESLEKHKHLLESTVNQGLSEAMNELDA----------VQREYQLVVQTTTEERRKVGNN 581
++ + L S Q S ++++L++ + + V+Q+T + +
Sbjct: 1025 RQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKE 1084
Query: 582 LQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKK 633
L +E HV + L ++ + R+ +E +E+ E + +R K +++
Sbjct: 1085 LSIQIEDERQHVNDQKDQLSLRVKALKRQVDE--AEEEIERLDGLRKKAQRE 1134
Score = 48.1 bits (113), Expect = 2e-05
Identities = 69/320 (21%), Positives = 129/320 (40%), Gaps = 46/320 (14%)
Query: 330 GLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEA 389
G E +VE + +E + Q + +Q +E E + LQ+ + + + +
Sbjct: 360 GQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQ 419
Query: 390 EQQKLWNEELKYARGKE---AIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAG 446
++L N + +G++ +ETQ+ E L KLK + +G E +K
Sbjct: 420 SNKELQNMKRLLDQGEDLRHGLETQVME---LQNKLKHV-QGPEPAK------------- 462
Query: 447 ANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTL----EQLNAMITESKRSVRT 502
V LK+LL ET E + + L K +E+ L +L A+ K V +
Sbjct: 463 -----------EVLLKDLL-ETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVAS 510
Query: 503 LKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQR 562
+EV+ + YQ+ ++ + + LE + + + V +GL + E
Sbjct: 511 RDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV-RGLQRELEETSEETG 569
Query: 563 EYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSEN 622
+Q + Q E+ R L +L +E+ L E+I + RE E+ + +
Sbjct: 570 HWQSMFQKNKEDLRATKQELLQL----RMEKEEMEEELGEKIEVLQRELEQARA-----S 620
Query: 623 IKEIRDKYEKKATLIKSSEE 642
+ R K L+++ EE
Sbjct: 621 AGDTRQVEVLKKELLRTQEE 640
Score = 31.2 bits (69), Expect = 3.1
Identities = 46/220 (20%), Positives = 96/220 (43%), Gaps = 35/220 (15%)
Query: 454 RAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMIT-------ESKRSV----RT 502
+A +Y L+E +E+E + + ++ + L +++ T E R V R
Sbjct: 315 KATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRK 374
Query: 503 LKEEVQKLDDLYQQKI---KEAEEEDEKCASELESLEKHKHLLESTVN--QGLSEAMNEL 557
L EEV+K L ++ ++ EE+ E+C+ E LE+ K + + Q + +++
Sbjct: 375 LDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQG 434
Query: 558 DAVQREYQLVVQTTTEERRKVGNN-------LQRLLEM--VATHVGSVEKHLEEQIAKVD 608
+ ++ + V + + V L+ LLE + V ++ +EEQ+ +
Sbjct: 435 EDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRE 494
Query: 609 REY--------EECMSEDLSENIKEIRDKYEKKATLIKSS 640
RE EE S D + ++ +R +Y++ ++ S
Sbjct: 495 RELTALKGALKEEVASRD--QEVEHVRQQYQRDTEQLRRS 532
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 70.1 bits (170), Expect = 6e-12
Identities = 89/419 (21%), Positives = 180/419 (42%), Gaps = 59/419 (14%)
Query: 264 KLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAI 323
+LE+ E K + +Q+ E + R+E+L + + + + N +
Sbjct: 2309 RLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVET 2368
Query: 324 LDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKL 383
L K+ G+ + + +EL+ TI+ E L N + ++ ++++E IN + Q
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ----- 2423
Query: 384 TKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNP 443
E EQ+K+ +E K + E ++TQL E L ++ + E K + +
Sbjct: 2424 ----EKEQEKVQMKE-KSSTAMEMLQTQLKE---LNERVAALHNDQEACKAKEQNLSSQV 2475
Query: 444 EAGANCLVKYRAQV----------YVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMI 493
E CL +AQ+ Y+ L+ +N +E+ K ++ + +L I
Sbjct: 2476 E----CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2531
Query: 494 TESKRSVRTLKE-------------EVQKLDDLYQQKIKEAEEEDEKCASELESLE-KHK 539
+ ++ V L + E++ L +QKI+ + ++ LE L+ +K
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2591
Query: 540 HL---LESTVNQGLS--EAMNELDA----VQREYQLVVQTTTE-------ERRKVGNNLQ 583
+L LE T +S E +N++ A +QRE + Q T E E+ ++ LQ
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQ 2651
Query: 584 RLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
LLE + + + K L + +++ + +CM +D E ++R++ + + +E+
Sbjct: 2652 LLLEEIKSSKDQL-KELTLENSELKKSL-DCMHKDQVEKEGKVREEIAEYQLRLHEAEK 2708
Score = 68.2 bits (165), Expect = 2e-11
Identities = 87/401 (21%), Positives = 178/401 (44%), Gaps = 65/401 (16%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQ 304
E N EL++ +L K++ L++KN +L + + L+ + N LE + K S
Sbjct: 2553 EQNLELRNLTVELEQ----KIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2608
Query: 305 GDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVA 364
V K A + L+ + QK L EE++ E + E LQ +++ K S
Sbjct: 2609 EKVNKMTAKETELQREMHEMAQKTAELQEELSG---EKNRLAGE---LQLLLEEIKSSKD 2662
Query: 365 DIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKL 424
++ + E +EL+++++ + KD ++ K+ E +Y + +L E K + L L
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEY-------QLRLHEAEKKHQALLL 2715
Query: 425 IPKGAENSKGYDFEIKFNPE---AGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMG 481
+ +K Y+ EI+ E + CL + ++ +LL ++EE+N +L
Sbjct: 2716 -----DTNKQYEVEIQTYREKLTSKEECLSSQKLEI-----DLLKSSKEELNNSLKATTQ 2765
Query: 482 LEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHL 541
+ LE+L ++ + V LK+E ++ + IK ++ LE+ K +
Sbjct: 2766 I---LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ-----------LEEEKEI 2811
Query: 542 LESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLE 601
L+ ++Q L A Q E++K G + ++ + T + +++ LE
Sbjct: 2812 LQKELSQ--------LQAAQ------------EKQKTGTVMDTKVDELTTEIKELKETLE 2851
Query: 602 EQIAKVDREYEECMSEDLS-ENIKEIRDKYEKKATLIKSSE 641
E+ + D ++ S +S E +++ ++ E + + S +
Sbjct: 2852 EKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892
Score = 65.5 bits (158), Expect = 1e-10
Identities = 85/409 (20%), Positives = 166/409 (40%), Gaps = 78/409 (19%)
Query: 234 ESFMSGADSFDEMNAELQSKLKDLFNV------DAFKLESLEAKNRA-LNEQIARLEQER 286
+S +S +MN++LQ + ++L + + K E + A +++I++L+++
Sbjct: 833 DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 287 EKEPN-------RLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVE 339
N LE+ K L V+ QA + L+ + +L+ L L +
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL-------Q 945
Query: 340 LECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEEL 399
L ET+ E + +II K + ++ + N E+ ++N+ +L + + N
Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN--- 1002
Query: 400 KYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYV 459
Y +E ++L++ +K KL L+ + E Y+ + KY+A
Sbjct: 1003 -YIDEREKSISELSDQYK-QEKLILLQRCEETGNAYE-----------DLSQKYKA---- 1045
Query: 460 PLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIK 519
A K LE L + ++ K + LKE K + K+
Sbjct: 1046 ---------------AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 520 EAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVG 579
AEE ++ ELE++++ L S + + + +E +++E + T EE+ K+
Sbjct: 1091 FAEERNQNLMLELETVQQ---ALRSEMTDNQNNSKSEAGGLKQE----IMTLKEEQNKMQ 1143
Query: 580 NNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECM---SEDLSENIKE 625
+ LL+ EQ+ KV + EC SE + ++KE
Sbjct: 1144 KEVNDLLQE------------NEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Score = 63.2 bits (152), Expect = 7e-10
Identities = 89/423 (21%), Positives = 179/423 (42%), Gaps = 40/423 (9%)
Query: 242 SFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKA 301
SF+ + E + + + + +E L+ + + LNE++A L ++E + ++L
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 302 SLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKY 361
L+ + + + +++ +L +NGL +E+ + + E +E +RL+N I +Q+
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536
Query: 362 SVADIERINHER---NELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKL 418
V+ + ++ E E + LT +LE QK+ + K A ++ +E + Y L
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELE---QKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 419 ARKLKLIPKGAENSKGYDFEIKFN----PEAGANCLVKYRAQVYVPLKELL----NETEE 470
+L+L F K N E + AQ L+E L N
Sbjct: 2594 ENELEL-----TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG 2648
Query: 471 EINKALNKKMGLEDTLEQLNAMITESKRSVRTL-KEEVQKLDDL------YQQKIKEAEE 523
E+ L + +D L++L +E K+S+ + K++V+K + YQ ++ EAE+
Sbjct: 2649 ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEK 2708
Query: 524 EDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQ 583
+ + + L K + T + L+ L + + E L+ + E + Q
Sbjct: 2709 KHQ---ALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765
Query: 584 RLLEMVAT------HVGSVEKHLEEQIAKVDREYEECM-----SEDLSENIKEIRDKYEK 632
L E+ T +V ++K E K+ + C E L + + +++ EK
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
Query: 633 KAT 635
+ T
Sbjct: 2826 QKT 2828
Score = 59.7 bits (143), Expect = 8e-09
Identities = 82/466 (17%), Positives = 191/466 (40%), Gaps = 64/466 (13%)
Query: 193 KIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQS 252
++ T K+++ L + E+T++ H L + +++++
Sbjct: 1966 ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE 2025
Query: 253 KLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQK--Y 310
LKD ++ KL+SLE ++AL+ LE + + E L K SLQ + + Y
Sbjct: 2026 LLKDKTHLQE-KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 311 QAYMSNLESHSAILDQ-----KLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVAD 365
+ + +A++++ +L+ EE+ ++ E ++ R++ Q +
Sbjct: 2085 EKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR---VRIEADEKKQLHIAEK 2141
Query: 366 IERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLI 425
++ E + L+ + L ++L+ ++ L K +ET + ++AR LK+
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKV- 2200
Query: 426 PKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMG---- 481
FE+ LV R++ +E + K + +K G
Sbjct: 2201 -----------FELD---------LVTLRSE------------KENLTKQIQEKQGQLSE 2228
Query: 482 LEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHL 541
L+ L +++ E +++ +KEE + ++ Q ++KE E + E ++ +
Sbjct: 2229 LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQS 2288
Query: 542 LESTVNQ------GLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGS 595
L+ + + + + L+A +++ V+Q E +++ V +
Sbjct: 2289 LDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA--------DLLKGRVEN 2340
Query: 596 VEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSE 641
+E+ LE IA+ ++E+ +E+ ++ ++ K E ++ E
Sbjct: 2341 LERELE--IARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLE 2384
Score = 54.3 bits (129), Expect = 3e-07
Identities = 96/480 (20%), Positives = 186/480 (38%), Gaps = 87/480 (18%)
Query: 245 EMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPN---RLESLRKLKA 301
E+ +L KLK F+L+SLEA AL +Q ++E E+ + N + L ++
Sbjct: 22 ELEGQLD-KLKKEKQQRQFQLDSLEA---ALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 302 SLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQN------- 354
SL+ QK + ES + +LN ++I ++E E + K E R Q
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 355 ---------------IIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEEL 399
+ +Q YS + E + + N+ + +L +++A Q K ++ L
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTL 197
Query: 400 KYAR------GKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIK------------- 440
A + + + + + L DF
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257
Query: 441 -------------FNPEAGANCLVKYRAQVYVPLKELLNET-------EEEINKALNKKM 480
F+ + + L + +AQ L+ +NE E+E+ +NK
Sbjct: 258 TLQIGKRDANSSFFDNSSSPHLLDQLKAQ-NQELRNKINELELRLQGHEKEMKGQVNKFQ 316
Query: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQ---KIKEAEEEDEKCASEL----E 533
L+ LE+ + E ++ + ++E+ + Y Q K E++ +K +L +
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ 376
Query: 534 SLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQ----------TTTEERRKVGNNLQ 583
+ E + LE + + E EL QR +Q + Q ++ + + N LQ
Sbjct: 377 NAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 584 RLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSEN-IKEIRDKYEKKATLIKSSEE 642
L+ + + +E +LEE K+ R + + + EN ++ ++ +K+ L+KS E
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Score = 53.5 bits (127), Expect = 6e-07
Identities = 75/343 (21%), Positives = 150/343 (43%), Gaps = 42/343 (12%)
Query: 321 SAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTI 380
+A++ G E+I ++L + EN RL ++I+++ V E + +E EL +
Sbjct: 1755 NALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKV---ESLLNEMKELDSKL 1811
Query: 381 N----KLTKDLEA--EQQKLWNEELKYARG-KEAIETQLAEYHKLARKLKLIPKGAENSK 433
+ +L +EA E +K+ E K E +E ++ +L +++ E S+
Sbjct: 1812 HLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRV-------ETSE 1864
Query: 434 GYDFEIKFNPEAGANCLVKYR-AQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNA- 491
G + +++ + + + + A+V KE + E E+++ ++K +E L A
Sbjct: 1865 GLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEAD 1924
Query: 492 --MITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQG 549
++ K + E QK+ ++++ E + EL+++ K L+ +++
Sbjct: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ-LSEK 1983
Query: 550 LSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVA------THVG----SVEK- 598
+ E EL++ Q E +Q E ++ LQ L V+ TH+ S+EK
Sbjct: 1984 MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD 2043
Query: 599 ---------HLEEQIAKVDREYEECMSEDLSENIKEIRDKYEK 632
LE QIA++++E E + E S + YEK
Sbjct: 2044 SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEK 2086
Score = 51.2 bits (121), Expect = 3e-06
Identities = 74/335 (22%), Positives = 141/335 (42%), Gaps = 78/335 (23%)
Query: 235 SFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLE 294
SF+ + ELQ ++ ++ A E L + L ++ L +E + ++L+
Sbjct: 2606 SFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLK 2665
Query: 295 SL----RKLKASL--------------QGDVQKYQAYMSNLE-SHSAILDQKLNGLNEEI 335
L +LK SL + ++ +YQ + E H A+ L +
Sbjct: 2666 ELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL-------LLDTN 2718
Query: 336 ARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLW 395
+ E+E +T +++ T + + +QK +I+ + + EL ++ T+ LE E +K
Sbjct: 2719 KQYEVEIQTYREKLTSKEECLSSQK---LEIDLLKSSKEELNNSLKATTQILE-ELKKTK 2774
Query: 396 NEELKYARGKEAIETQLAEYHKLAR-KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYR 454
+ LKY QL + ++ A+ K+KL+ K +
Sbjct: 2775 MDNLKYV-------NQLKKENERAQGKMKLLIKSCKQ----------------------- 2804
Query: 455 AQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLY 514
L E +E + K L++ ++ +Q + ++K V L E+++L +
Sbjct: 2805 ----------LEEEKEILQKELSQLQAAQE--KQKTGTVMDTK--VDELTTEIKELKETL 2850
Query: 515 QQKIKEAEEEDEKCASEL---ESLEKHKHLLESTV 546
++K KEA+E +K S L E LEK K +LE+ V
Sbjct: 2851 EEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 50.4 bits (119), Expect = 5e-06
Identities = 95/451 (21%), Positives = 195/451 (43%), Gaps = 78/451 (17%)
Query: 264 KLESLEAKNRALNE--QIARLEQEREKEPNRLESL-----RKLKASLQGDVQKYQAYMSN 316
KL E +++AL ++ + E E KE L S KL ++ + + Q+ +++
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 317 LESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSV------------- 363
LE+ K + NE + +E++ E + E L N++D++ V
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 364 ADIERINHERNELQQTINKLT------KDLEAEQQKLWNEELKYARGKEAIETQLAEYHK 417
A+ H++ E++ K + +DLE + Q L NE + R + + AEY
Sbjct: 707 AEFSDQKHQK-EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLH---AEYES 762
Query: 418 LARKLKLIPKGAENSKGYDFE---IKFNPEAG-----ANCLVKYRAQVYVPLKELLNETE 469
L LK K A D + + F+ + AN + + + + L +
Sbjct: 763 LRDLLK--SKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 470 EEINKAL--NKKMGLEDTLEQLNAMITESKRSVRTL-------KEEVQKLDDLYQ----- 515
N A+ N+ LE +LE M ++ ++ L +E + K + ++Q
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE 880
Query: 516 --QKIKEAEEEDE-------KCASELESLEKHKHLLESTVN------QGLSEAMNELDAV 560
Q+I + +E+ + S LE+ EK LL V Q L ++ + L+
Sbjct: 881 TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDS 940
Query: 561 QREYQLVVQTTTEERRKVGNNL---QRLLEMVATHVGSVEK---HLEEQIAKVDREYEEC 614
+E QL+ +T + E++++ + + +R +E + G++++ L ++ + ++ E
Sbjct: 941 LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
Query: 615 MS--EDLSENIKEIRDKY-EKKATLIKSSEE 642
+ ++ ++I E+ D+Y ++K L++ EE
Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEE 1031
Score = 49.7 bits (117), Expect = 8e-06
Identities = 88/426 (20%), Positives = 193/426 (45%), Gaps = 43/426 (10%)
Query: 231 KCYESFMSGADSFDEMNAE---LQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQERE 287
KC + + +D+ + + L+ KLK L + + ++ E+ +L ++I E+E +
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ 397
Query: 288 KEPNRLE-SLRKL-KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETI 345
+E +R + S + L + +Q + Q H+ +L +L+ L ++E E
Sbjct: 398 EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN-VLQAELDKLTSVKQQLENNLEEF 456
Query: 346 KQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKD---LEAEQQKLWNEELKYA 402
KQ+ R + Q + + I + NEL++++ ++ K+ L++ ++ E
Sbjct: 457 KQKLCRAE-----QAFQASQI-----KENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506
Query: 403 RGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLK 462
+ I+ L + A ++K ++ + D + K N + + L K + V
Sbjct: 507 AELKNIKQCLNQSQNFAEEMK-AKNTSQETMLRDLQEKINQQENSLTLEKLKLAV----A 561
Query: 463 ELLNETEEEINKALNKKMGLEDTLEQLNAMIT----ESKRSVRTLKEEVQKLDDLYQQKI 518
+L E + + ++ L KK E +EQLN ++ ESK + L+ + ++ ++L ++K
Sbjct: 562 DL--EKQRDCSQDLLKKR--EHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 519 KEA--EEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERR 576
+ + E+EK +++ES K L+S +N L + EY V+T +R
Sbjct: 618 LFSCWKSENEKLLTQMES---EKENLQSKINH-LETCLKTQQIKSHEYNERVRTLEMDRE 673
Query: 577 KVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATL 636
+ ++ L ++ + VE +++A ++ + + S+ ++ KEI + K + L
Sbjct: 674 NLSVEIRNLHNVLDSKSVEVE---TQKLAYMELQQKAEFSD--QKHQKEIENMCLKTSQL 728
Query: 637 IKSSEE 642
E+
Sbjct: 729 TGQVED 734
Score = 48.9 bits (115), Expect = 1e-05
Identities = 80/371 (21%), Positives = 153/371 (41%), Gaps = 66/371 (17%)
Query: 265 LESLEAKNRALNEQIARLE---QEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHS 321
L+ L+A+N+ L +I LE Q EKE ++G V K+Q LE
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKE-------------MKGQVNKFQELQLQLEK-- 324
Query: 322 AILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTIN 381
A+VEL I++E L D + A ++ + + L+Q +
Sbjct: 325 --------------AKVEL----IEKEKV-LNKCRDELVRTTAQYDQASTKYTALEQKLK 365
Query: 382 KLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKF 441
KLT+DL ++Q AE + + + K+ K E + + +
Sbjct: 366 KLTEDLSCQRQN-------------------AESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 442 NPEAGANCL-VKYR-AQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRS 499
C+ +K R Q K + N + E++K + K LE+ LE+ + ++++
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466
Query: 500 VRTLKEEVQKLDDLYQQKIKE---AEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNE 556
+ + + +L ++ KE + E+ A E+ LE ++ +NQ + A E
Sbjct: 467 FQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA-EE 525
Query: 557 LDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLE--EQIAKVDREYEEC 614
+ A + +++ E+ + N+L LE + V +EK + + + K + E
Sbjct: 526 MKAKNTSQETMLRDLQEKINQQENSL--TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQ 583
Query: 615 MSEDLSENIKE 625
+++ LS+ KE
Sbjct: 584 LNDKLSKTEKE 594
Score = 47.4 bits (111), Expect = 4e-05
Identities = 84/453 (18%), Positives = 181/453 (39%), Gaps = 86/453 (18%)
Query: 241 DSFDEMNAELQ--SKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRK 298
D + + ELQ + ++L +DA E+ +A+ L QI + + + L +LR
Sbjct: 2154 DKVENLERELQMSEENQELVILDA---ENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210
Query: 299 LKASLQGDVQKYQAYMSNLE----SHSAILDQK---------------------LNGLNE 333
K +L +Q+ Q +S L+ S ++L++K L LNE
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 334 EIARVELECETIK----------QENTRLQNIIDN-----------QKYSVADIERINHE 372
+A + + E +K +E +L+N I+ Q + ++ H
Sbjct: 2271 AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHH 2330
Query: 373 RNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENS 432
+ L+ + L ++LE + + L+ K +ET A+ + + L
Sbjct: 2331 ADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL---------- 2380
Query: 433 KGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAM 492
+G + ++ V R++ EL E +E I++ E+ L++
Sbjct: 2381 RGLELDV-----------VTIRSEKENLTNELQKE-QERISELEIINSSFENILQEKEQE 2428
Query: 493 ITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLE---STVNQG 549
+ K T E +Q +++ + E C ++ ++L LE + + QG
Sbjct: 2429 KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG 2488
Query: 550 LSEAMNELDAVQREYQLVVQTTTEERRKV---GNNLQRLLEMVATHVGSVEKHLEEQIAK 606
L EA N +Q ++Q + ++K+ + RL + ++ L ++++
Sbjct: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-----QEQLVSKLSQ 2543
Query: 607 VDREYEECMSEDLSENIKEIRDKYEKKATLIKS 639
V+ E++ ++L ++ + + E+K +++S
Sbjct: 2544 VEGEHQLWKEQNL--ELRNLTVELEQKIQVLQS 2574
Score = 39.7 bits (91), Expect = 0.009
Identities = 89/395 (22%), Positives = 159/395 (40%), Gaps = 53/395 (13%)
Query: 253 KLKDLFNVDAFKLESLEAKNRAL----NEQIARLEQEREKEPNRLESLRKLKASLQGDVQ 308
+L+ L V LE LE K + N++I LEQ E L+ LRK S
Sbjct: 1551 ELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLS------ 1604
Query: 309 KYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIER 368
+ + + L S + ++ KL ++ ++ LE E + + L + ++ D E
Sbjct: 1605 ENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLD--LSSRSLLGIDTED 1662
Query: 369 INHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKG 428
RNE + T + K ++ K+A + + K+ + P G
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPK---HDVHQICDKDAQQDLNLDIEKITETGAVKPTG 1719
Query: 429 ---AENSKGYDFEI--KFNPEAGANCLVKYR---AQVYVPLKELLNETEEEINKALNKKM 480
E S ++E + + + C+ + VP+ + L E+ N L K
Sbjct: 1720 ECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPM-DFLGNQEDIHNLQLRVKE 1778
Query: 481 GLEDTLEQLNAMITESKRSVRTLKEEVQKLDD-LYQQKIK-----EAEEEDEKCASELES 534
+ L L+ +I + R V +L E+++LD L+ Q+++ EA E EK EL+
Sbjct: 1779 TSNENLRLLH-VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKK 1837
Query: 535 LEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVG 594
N LSE +L+ ++Q ++Q R + L LEM A
Sbjct: 1838 -----------ENSDLSE---KLEYFSCDHQELLQ-----RVETSEGLNSDLEMHADK-- 1876
Query: 595 SVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDK 629
S + + + +AKV+ ++E D+ + IR +
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFL-DVENELSRIRSE 1910
Score = 33.1 bits (74), Expect = 0.81
Identities = 28/135 (20%), Positives = 67/135 (49%), Gaps = 9/135 (6%)
Query: 485 TLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLES 544
+L++ N E+ + EE++ L ++Y+Q +++ EE+ E + + K+K + E
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEK-----MESQGIMKNKEIQE- 1583
Query: 545 TVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQI 604
+ Q LS ELD ++++Y + + +++ L+ ++ A + + LE ++
Sbjct: 1584 -LEQLLSSERQELDCLRKQY--LSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEV 1640
Query: 605 AKVDREYEECMSEDL 619
A++ + + S L
Sbjct: 1641 ARLQLQGLDLSSRSL 1655
>gi|219555661 intraflagellar transport 81-like isoform 1 [Homo
sapiens]
Length = 676
Score = 68.6 bits (166), Expect = 2e-11
Identities = 102/452 (22%), Positives = 181/452 (40%), Gaps = 63/452 (13%)
Query: 235 SFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIAR-LEQEREKEPNRL 293
S S A+ +++A + K + + V+ K A+N +IAR L E+E+E
Sbjct: 164 SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLES-HSAILDQK----LNGLNEEIA--------RVEL 340
+ ++ K L VQ+ Q + L+S A D K + L EEI +
Sbjct: 224 QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
Query: 341 ECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELK 400
E E K+E LQ ++ +D+ + + NE+ IN+L + + + +
Sbjct: 284 ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343
Query: 401 YARGKEAI----ETQLAEYHKLARKLKLIPK-------------GAENSKGYDFEIKFNP 443
Y + I E + E + KL + + G E KG +F+ N
Sbjct: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403
Query: 444 EAGANCLVKYRAQVYVPLKE---LLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSV 500
+ + K + Q+ LK LL TEE + K E+ +QL M E K+ +
Sbjct: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELL------KQRHENIQQQLQTM--EEKKGI 455
Query: 501 RTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAV 560
++L+ + K E +E + ++ + K + L S L+ + EL +
Sbjct: 456 SGYSYTQEELERVSALK-SEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL 514
Query: 561 QREYQLVVQTTTEE--------------RRKVGNNLQRLLEMVAT------HVGSVEKHL 600
+++YQ + Q E+ R K+ ++RL E + + K+L
Sbjct: 515 RQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNL 574
Query: 601 EEQIAKVDREYEECMSEDLSENIKEIRDKYEK 632
E Q+ + E + +S D E K IR++Y K
Sbjct: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQYTK 606
Score = 40.8 bits (94), Expect = 0.004
Identities = 83/390 (21%), Positives = 165/390 (42%), Gaps = 67/390 (17%)
Query: 313 YMSNLESHSAIL-DQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINH 371
++ LE S L D+ + N++ + +T+ +E +L+ + DI +
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
Query: 372 ERNELQQTINKLTKDLEAEQQKLWNEEL-KYARGKEAIETQLAE---------YHKLAR- 420
E+++L + + L K +E Q W ++ + R ++ E LA+ +H + R
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
Query: 421 -----KLKLIPKGAENSKGYDF------EIKFN--------PEAGANC---------LVK 452
+LK + + A ++K EIKFN P+ N +V
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
Query: 453 YRAQVYVPLKEL---LNETEEEINKALNKKMGLEDTLE--------QLNAMITESKRSVR 501
A + L EL +NE EIN+ + KKM + +E Q + + + +
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
Query: 502 TLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLL-----ESTVNQGLSEAMNE 556
L+E +KL L ++ + + E +E+ ++ K + +STV + + + E
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420
Query: 557 LDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVG----SVEKHLEEQIAKVDREYE 612
L A E+ L +Q T E ++ N+Q+ L+ + G S + E+++ + E +
Sbjct: 421 LKA---EFGL-LQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVD 476
Query: 613 ECMS---EDLSENIKEIRDKYEKKATLIKS 639
E +D+SE +K++ +K + + S
Sbjct: 477 EMKGRTLDDMSEMVKKLYSLVSEKKSALAS 506
>gi|32526901 intraflagellar transport 81-like isoform 1 [Homo
sapiens]
Length = 676
Score = 68.6 bits (166), Expect = 2e-11
Identities = 102/452 (22%), Positives = 181/452 (40%), Gaps = 63/452 (13%)
Query: 235 SFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIAR-LEQEREKEPNRL 293
S S A+ +++A + K + + V+ K A+N +IAR L E+E+E
Sbjct: 164 SGFSTAEIRKDISAMEEEKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLA 223
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLES-HSAILDQK----LNGLNEEIA--------RVEL 340
+ ++ K L VQ+ Q + L+S A D K + L EEI +
Sbjct: 224 QQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPK 283
Query: 341 ECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELK 400
E E K+E LQ ++ +D+ + + NE+ IN+L + + + +
Sbjct: 284 ELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSL 343
Query: 401 YARGKEAI----ETQLAEYHKLARKLKLIPK-------------GAENSKGYDFEIKFNP 443
Y + I E + E + KL + + G E KG +F+ N
Sbjct: 344 YRQQASIISRKKEAKAEELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNK 403
Query: 444 EAGANCLVKYRAQVYVPLKE---LLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSV 500
+ + K + Q+ LK LL TEE + K E+ +QL M E K+ +
Sbjct: 404 LRSKSTVFKKKHQIIAELKAEFGLLQRTEELL------KQRHENIQQQLQTM--EEKKGI 455
Query: 501 RTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAV 560
++L+ + K E +E + ++ + K + L S L+ + EL +
Sbjct: 456 SGYSYTQEELERVSALK-SEVDEMKGRTLDDMSEMVKKLYSLVSEKKSALASVIKELRQL 514
Query: 561 QREYQLVVQTTTEE--------------RRKVGNNLQRLLEMVAT------HVGSVEKHL 600
+++YQ + Q E+ R K+ ++RL E + + K+L
Sbjct: 515 RQKYQELTQECDEKKSQYDSCAAGLESNRSKLEQEVRRLREECLQEESRYHYTNCMIKNL 574
Query: 601 EEQIAKVDREYEECMSEDLSENIKEIRDKYEK 632
E Q+ + E + +S D E K IR++Y K
Sbjct: 575 EVQLRRATDEMKAYISSDQQEKRKAIREQYTK 606
Score = 40.8 bits (94), Expect = 0.004
Identities = 83/390 (21%), Positives = 165/390 (42%), Gaps = 67/390 (17%)
Query: 313 YMSNLESHSAIL-DQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINH 371
++ LE S L D+ + N++ + +T+ +E +L+ + DI +
Sbjct: 121 FLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE 180
Query: 372 ERNELQQTINKLTKDLEAEQQKLWNEEL-KYARGKEAIETQLAE---------YHKLAR- 420
E+++L + + L K +E Q W ++ + R ++ E LA+ +H + R
Sbjct: 181 EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRL 240
Query: 421 -----KLKLIPKGAENSKGYDF------EIKFN--------PEAGANC---------LVK 452
+LK + + A ++K EIKFN P+ N +V
Sbjct: 241 QRVQNQLKSMRQAAADAKPESLMKRLEEEIKFNLYMVTEKFPKELENKKKELHFLQKVVS 300
Query: 453 YRAQVYVPLKEL---LNETEEEINKALNKKMGLEDTLE--------QLNAMITESKRSVR 501
A + L EL +NE EIN+ + KKM + +E Q + + + +
Sbjct: 301 EPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE 360
Query: 502 TLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLL-----ESTVNQGLSEAMNE 556
L+E +KL L ++ + + E +E+ ++ K + +STV + + + E
Sbjct: 361 ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAE 420
Query: 557 LDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVG----SVEKHLEEQIAKVDREYE 612
L A E+ L +Q T E ++ N+Q+ L+ + G S + E+++ + E +
Sbjct: 421 LKA---EFGL-LQRTEELLKQRHENIQQQLQTMEEKKGISGYSYTQEELERVSALKSEVD 476
Query: 613 ECMS---EDLSENIKEIRDKYEKKATLIKS 639
E +D+SE +K++ +K + + S
Sbjct: 477 EMKGRTLDDMSEMVKKLYSLVSEKKSALAS 506
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 68.6 bits (166), Expect = 2e-11
Identities = 101/426 (23%), Positives = 179/426 (42%), Gaps = 53/426 (12%)
Query: 244 DEMNAELQSKLKDLFNVDAFKLESLEAKNRALN----------EQIARLEQEREKEPNRL 293
DE A+L + K L L+ L+A+ +N +Q+ LE E+E
Sbjct: 989 DETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR 1048
Query: 294 ESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQ 353
L + K L+GD++ Q ++E+ LD+KL EI+ + + E + +LQ
Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108
Query: 354 NIIDNQKYSVADI-ERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQL 412
I + + ++ E I ER + K DL E +++ +E L+ A G + + +L
Sbjct: 1109 KKIKELQARIEELGEEIEAERAS-RAKAEKQRSDLSRELEEI-SERLEEAGGATSAQVEL 1166
Query: 413 -----AEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNE 467
AE+ KL R L+ E EA L K A L E ++
Sbjct: 1167 NKKREAEFQKLRRDLE--------------EATLQHEAMVAALRKKHADSMAELGEQIDN 1212
Query: 468 TEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEK 527
+ K +K L+ + L++ ++ L++ + L+D + +K EEE ++
Sbjct: 1213 LQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE-LKTKEEEQQR 1271
Query: 528 CASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTT----------EERRK 577
++L + + L++ + S ++E DA+ + Q +T EE K
Sbjct: 1272 LINDLTA---QRARLQTEAGE-YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETK 1327
Query: 578 VGNNLQRLLEMVATHVGSV-EKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATL 636
N L L+ + E++ EEQ K E + +S+ SE + + R KYE A
Sbjct: 1328 AKNALAHALQSSRHDCDLLREQYEEEQEGKA--ELQRALSKANSE-VAQWRTKYETDA-- 1382
Query: 637 IKSSEE 642
I+ +EE
Sbjct: 1383 IQRTEE 1388
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/421 (21%), Positives = 172/421 (40%), Gaps = 39/421 (9%)
Query: 254 LKDLFNVDAFKLESLEAKNRALNEQIARLEQEREK--------------EPNRLESLRKL 299
+K+ F +L EAK + L E++ L +E+ R E L K
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 300 KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARV-------ELECETIKQENTRL 352
K L+ +++ E +A L K L +E + + EL +++E
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974
Query: 353 QNIIDNQKYSVADIE----RINHERNELQQTINKLTKDLEAEQQK---LWNEELKYARGK 405
+N + N +A ++ +++ E+ LQ+T + DL+AE+ K L + K +
Sbjct: 975 ENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQV 1034
Query: 406 EAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELL 465
+ +E L + KL L+ + E E + E L + + + L+
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI 1094
Query: 466 NETEEE--INKALNKKM-GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAE 522
++ E+E + L KK+ L+ +E+L I E++R+ R E+ + ++I E
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQARIEELGEEI-EAERASRAKAEKQRSDLSRELEEISERL 1153
Query: 523 EEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNL 582
EE S L K + + + L EA + +A+ + + E + +NL
Sbjct: 1154 EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNL 1213
Query: 583 QRLLEMVATHVGSVEKHLE------EQIAKVDREYEECMSEDLSENIKEIRDKYEKKATL 636
QR+ + + ++ + E I+K E+ M L + + E++ K E++ L
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEK-MCRSLEDQVSELKTKEEEQQRL 1272
Query: 637 I 637
I
Sbjct: 1273 I 1273
Score = 60.5 bits (145), Expect = 5e-09
Identities = 98/464 (21%), Positives = 192/464 (41%), Gaps = 79/464 (17%)
Query: 247 NAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGD 306
NAE SK K +LE R+L +Q++ L+ + E++ + L +A LQ +
Sbjct: 1237 NAEAISKAKG----------NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTE 1286
Query: 307 VQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADI 366
+Y + ++ + L + ++I ++ + E + L + + + ++ D+
Sbjct: 1287 AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD-CDL 1345
Query: 367 ERINHERN-----ELQQTINKLTKDLEAEQQKLWN------EELKYARGKEAIETQLAEY 415
R +E ELQ+ ++K ++ + K EEL+ A+ K A Q AE
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1405
Query: 416 HKLARKLKL--IPKGAENSKGYDFEIKFNPE-AGANCLVKYRAQ-----VYVPLKELLNE 467
H A K + K + + ++ + E + A C + Q V K+ E
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEE 1465
Query: 468 TEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEE----VQKLDDLYQQ------K 517
T+ E+ + + L L ++ + ES + TL+ E Q++ DL +Q +
Sbjct: 1466 TQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQ 1525
Query: 518 IKEAEE-----EDEKCA-----SELESLEKHK-----------HLLESTVNQGLSEAMNE 556
I E E+ E EKC E E+ +H+ + ++S V++ ++E E
Sbjct: 1526 IHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1585
Query: 557 LDAVQREYQLVVQT---TTEERRKVGNNLQRLLEMVATHVGSVE---KHLEEQIAKVDRE 610
+D ++R + VV+T T + + N+ R+ + + + +E H A+ R
Sbjct: 1586 IDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRN 1645
Query: 611 YEECMS---------EDL---SENIKEIRDKYEKKATLIKSSEE 642
Y +D E++KE E++A L+++ E
Sbjct: 1646 YRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIE 1689
Score = 54.7 bits (130), Expect = 3e-07
Identities = 102/498 (20%), Positives = 205/498 (41%), Gaps = 125/498 (25%)
Query: 243 FDEMNAELQS-------------KLKDLFNVDAFKLESLEAKNRALNEQIARLEQ---ER 286
++E AEL++ K+K+++ +LE+L +N+ L ++I+ L + E
Sbjct: 1463 YEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEG 1522
Query: 287 EKEPNRLESLRKL----KASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEE----IARV 338
K+ + LE ++K K +Q +++ +A + + E + +LN + E IA
Sbjct: 1523 GKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1582
Query: 339 ELECETIKQENTR----LQNIIDNQKYSVADIERINHER----NELQQTINKLTKDLEAE 390
+ E + +K+ +TR +Q+ +D + S D R+ + NE++ +N + L AE
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANR-LAAE 1641
Query: 391 QQKLWNEE---LKYA--------RGKEAIETQLAEYHKLARKLKL--------IPKGAEN 431
+ + LK RG+E ++ QLA + A L+ + + +
Sbjct: 1642 SLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERS 1701
Query: 432 SKGYDFEIKFNPE------AGANCLVKYRAQVYVPLKELLNETEEEINKALNK------- 478
K + E+ E L+ + ++ + +L +E EE I ++ N
Sbjct: 1702 RKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKA 1761
Query: 479 ------------------------KMGLEDTLEQLNAMITESKR-SVRTLKEEVQKLDDL 513
K LE T++ L + E+++ +++ K+++QKL+
Sbjct: 1762 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR 1821
Query: 514 YQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTE 573
++ E E E ++ A ++ L KH+ ++ Q TE
Sbjct: 1822 VRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQ-----------------------TE 1858
Query: 574 ERRKVGNNLQRLLEMVATHVGSVEKHLEE----------QIAKVDREYEECMSE-DLSEN 622
E RK LQ L++ + V S ++ EE + K+ E EE D++E+
Sbjct: 1859 EDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAES 1918
Query: 623 -IKEIRDKYEKKATLIKS 639
+ ++R K + T I +
Sbjct: 1919 QVNKLRVKSREVHTKISA 1936
Score = 45.8 bits (107), Expect = 1e-04
Identities = 64/277 (23%), Positives = 123/277 (44%), Gaps = 52/277 (18%)
Query: 380 INKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEI 439
I L K E E++ +E ++ + K+ + A+ +L K+ + K D ++
Sbjct: 839 IKPLLKSAETEKEMATMKE-EFQKTKDELAKSEAKRKELEEKMVTLLKEKN-----DLQL 892
Query: 440 KFNPEAGA------NC--LVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNA 491
+ EA + C L+K + Q+ +KE+ EEE E++NA
Sbjct: 893 QVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE---------------EEINA 937
Query: 492 MITESKRSVRTLKEEVQK-LDDLYQQKIKEAEEEDEKCASELESLEKHKHLLE--STVNQ 548
+T KR + E++K +DDL ++ A+ E EK A+E K K+L E + +++
Sbjct: 938 ELTAKKRKLEDECSELKKDIDDL---ELTLAKVEKEKHATE----NKVKNLTEEMAGLDE 990
Query: 549 GLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQ----- 603
+++ E A+Q +Q + E KV N L + + V +E LE++
Sbjct: 991 TIAKLSKEKKALQETHQQTLDDLQAEEDKV-NILTKAKTKLEQQVDDLEGSLEQEKKLRM 1049
Query: 604 -IAKVDREYE------ECMSEDLSENIKEIRDKYEKK 633
+ + R+ E + + D+ + +++ +K EKK
Sbjct: 1050 DLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKK 1086
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 68.2 bits (165), Expect = 2e-11
Identities = 112/458 (24%), Positives = 206/458 (44%), Gaps = 60/458 (13%)
Query: 213 EETEDGIMHNKLF-LDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAK 271
+ETE+ NK+ L + C E + D+ + + + L N KL +E
Sbjct: 883 KETEEN--ENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENI 940
Query: 272 NRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLE-SHSAILDQKLNG 330
+ N +I L+Q RE LE L+KL +Q +A + +LE SH L+ L
Sbjct: 941 MHSQNCEIKELKQSREIV---LEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQV 997
Query: 331 LN-EEIARV----ELECETIKQENTRLQNIIDNQKYSVAD-----IERINHERNELQQTI 380
+ +E +V + E +K+EN ++ N I + ++ + + ++L T
Sbjct: 998 RHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTR 1057
Query: 381 NKLT-----KDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARK--LKLIPKGAENSK 433
KL K+ E ++ K+ EE + A+ KE +++ L + + R KL K +N++
Sbjct: 1058 CKLEVELALKEAETDEIKILLEESR-AQQKETLKSLLEQETENLRTEISKLNQKIQDNNE 1116
Query: 434 GYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMI 493
Y + A + + EL++ EEE N L+ L ++ ++
Sbjct: 1117 NYQVGL-------AELRTLMTIEKDQCISELISRHEEESNI-------LKAELNKVTSLH 1162
Query: 494 TESKRSVRTLKEEV----QKLDD----LYQQKIKEAEEEDEKCASELESLEKHKHLLEST 545
++ + LKE++ KLD L +QK ++ +++EK + +++LEK + L S+
Sbjct: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS 1222
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIA 605
Q + + +L+ + E +QT +E + L+R E+V + KHLE QIA
Sbjct: 1223 QEQDREQLIQKLNCEKDE---AIQTALKEFK-----LER--EVVEKELLEKVKHLENQIA 1272
Query: 606 KVDREYEECMSEDLSENIKEIRDK-YEKKATLIKSSEE 642
K + D S + E+++K E+KA ++ EE
Sbjct: 1273 K--SPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEE 1308
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/387 (21%), Positives = 163/387 (42%), Gaps = 67/387 (17%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESL------------ 296
EL+ K+ DL + L K +E LE+ R ++ L+SL
Sbjct: 1045 ELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEI 1104
Query: 297 RKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNII 356
KL +Q + + YQ ++ L + I +K ++E I+R E E +K E ++ ++
Sbjct: 1105 SKLNQKIQDNNENYQVGLAELRTLMTI--EKDQCISELISRHEEESNILKAELNKVTSL- 1161
Query: 357 DNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYH 416
NQ + + E+N L++ I +L L++E L ++ E I Q +Y
Sbjct: 1162 HNQAFEI--------EKN-LKEQIIELQSKLDSELSALERQK------DEKITQQEEKYE 1206
Query: 417 KLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKAL 476
+ + L+ + +S+ D E NC + + LKE E E + L
Sbjct: 1207 AIIQNLEKDRQKLVSSQEQDREQLIQK---LNC--EKDEAIQTALKEFKLEREVVEKELL 1261
Query: 477 NKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELES-- 534
K LE+ + + A+ + S + E +KL + + +++ EE++++ E+++
Sbjct: 1262 EKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVR 1321
Query: 535 --------------LEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGN 580
L + K E+ +N LS+ + Q + ++++ +E+R
Sbjct: 1322 TSLIAEQQTNFNTVLTREKMRKENIIND-LSDKLKSTMQQQERDKDLIESLSEDR----- 1375
Query: 581 NLQRLLEMVATHVGSVEKHLEEQIAKV 607
RLLE +K LEE+++K+
Sbjct: 1376 --ARLLE--------EKKKLEEEVSKL 1392
Score = 30.0 bits (66), Expect = 6.9
Identities = 37/171 (21%), Positives = 72/171 (42%), Gaps = 29/171 (16%)
Query: 486 LEQLNAMITESKRSVRTLKEE-------VQKLDDLYQQKIK-EAEE-----EDEKCASEL 532
LE+ + +S S++T+KE+ VQK + +K A E E KC+ E+
Sbjct: 798 LERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEI 857
Query: 533 ESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLL-EMVAT 591
EKH+ EL +++ EY+ + +E + N +++L E+V
Sbjct: 858 TLKEKHQ---------------KELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCL 902
Query: 592 HVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
K E + K ++E C+ + + + E+ + + IK ++
Sbjct: 903 EEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQ 953
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 68.2 bits (165), Expect = 2e-11
Identities = 112/458 (24%), Positives = 206/458 (44%), Gaps = 60/458 (13%)
Query: 213 EETEDGIMHNKLF-LDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAK 271
+ETE+ NK+ L + C E + D+ + + + L N KL +E
Sbjct: 883 KETEEN--ENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENI 940
Query: 272 NRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLE-SHSAILDQKLNG 330
+ N +I L+Q RE LE L+KL +Q +A + +LE SH L+ L
Sbjct: 941 MHSQNCEIKELKQSREIV---LEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQV 997
Query: 331 LN-EEIARV----ELECETIKQENTRLQNIIDNQKYSVAD-----IERINHERNELQQTI 380
+ +E +V + E +K+EN ++ N I + ++ + + ++L T
Sbjct: 998 RHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTR 1057
Query: 381 NKLT-----KDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARK--LKLIPKGAENSK 433
KL K+ E ++ K+ EE + A+ KE +++ L + + R KL K +N++
Sbjct: 1058 CKLEVELALKEAETDEIKILLEESR-AQQKETLKSLLEQETENLRTEISKLNQKIQDNNE 1116
Query: 434 GYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMI 493
Y + A + + EL++ EEE N L+ L ++ ++
Sbjct: 1117 NYQVGL-------AELRTLMTIEKDQCISELISRHEEESNI-------LKAELNKVTSLH 1162
Query: 494 TESKRSVRTLKEEV----QKLDD----LYQQKIKEAEEEDEKCASELESLEKHKHLLEST 545
++ + LKE++ KLD L +QK ++ +++EK + +++LEK + L S+
Sbjct: 1163 NQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSS 1222
Query: 546 VNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIA 605
Q + + +L+ + E +QT +E + L+R E+V + KHLE QIA
Sbjct: 1223 QEQDREQLIQKLNCEKDE---AIQTALKEFK-----LER--EVVEKELLEKVKHLENQIA 1272
Query: 606 KVDREYEECMSEDLSENIKEIRDK-YEKKATLIKSSEE 642
K + D S + E+++K E+KA ++ EE
Sbjct: 1273 K--SPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEE 1308
Score = 48.1 bits (113), Expect = 2e-05
Identities = 84/387 (21%), Positives = 163/387 (42%), Gaps = 67/387 (17%)
Query: 249 ELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESL------------ 296
EL+ K+ DL + L K +E LE+ R ++ L+SL
Sbjct: 1045 ELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEI 1104
Query: 297 RKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNII 356
KL +Q + + YQ ++ L + I +K ++E I+R E E +K E ++ ++
Sbjct: 1105 SKLNQKIQDNNENYQVGLAELRTLMTI--EKDQCISELISRHEEESNILKAELNKVTSL- 1161
Query: 357 DNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYH 416
NQ + + E+N L++ I +L L++E L ++ E I Q +Y
Sbjct: 1162 HNQAFEI--------EKN-LKEQIIELQSKLDSELSALERQK------DEKITQQEEKYE 1206
Query: 417 KLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKAL 476
+ + L+ + +S+ D E NC + + LKE E E + L
Sbjct: 1207 AIIQNLEKDRQKLVSSQEQDREQLIQK---LNC--EKDEAIQTALKEFKLEREVVEKELL 1261
Query: 477 NKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELES-- 534
K LE+ + + A+ + S + E +KL + + +++ EE++++ E+++
Sbjct: 1262 EKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVR 1321
Query: 535 --------------LEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGN 580
L + K E+ +N LS+ + Q + ++++ +E+R
Sbjct: 1322 TSLIAEQQTNFNTVLTREKMRKENIIND-LSDKLKSTMQQQERDKDLIESLSEDR----- 1375
Query: 581 NLQRLLEMVATHVGSVEKHLEEQIAKV 607
RLLE +K LEE+++K+
Sbjct: 1376 --ARLLE--------EKKKLEEEVSKL 1392
Score = 30.0 bits (66), Expect = 6.9
Identities = 37/171 (21%), Positives = 72/171 (42%), Gaps = 29/171 (16%)
Query: 486 LEQLNAMITESKRSVRTLKEE-------VQKLDDLYQQKIK-EAEE-----EDEKCASEL 532
LE+ + +S S++T+KE+ VQK + +K A E E KC+ E+
Sbjct: 798 LERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEI 857
Query: 533 ESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLL-EMVAT 591
EKH+ EL +++ EY+ + +E + N +++L E+V
Sbjct: 858 TLKEKHQ---------------KELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCL 902
Query: 592 HVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE 642
K E + K ++E C+ + + + E+ + + IK ++
Sbjct: 903 EEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQ 953
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,098,296
Number of Sequences: 37866
Number of extensions: 991900
Number of successful extensions: 9634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 226
Number of HSP's successfully gapped in prelim test: 926
Number of HSP's that attempted gapping in prelim test: 4960
Number of HSP's gapped (non-prelim): 3327
length of query: 642
length of database: 18,247,518
effective HSP length: 109
effective length of query: 533
effective length of database: 14,120,124
effective search space: 7526026092
effective search space used: 7526026092
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.