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Search of human proteins with 5174421
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174421 copine 6 [Homo sapiens]
(557 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174421 copine 6 [Homo sapiens] 1139 0.0
gi|25141328 copine 7 isoform a [Homo sapiens] 723 0.0
gi|18677733 copine IV [Homo sapiens] 702 0.0
gi|7656993 copine 7 isoform b [Homo sapiens] 627 e-180
gi|4503015 copine III [Homo sapiens] 571 e-163
gi|30181236 copine II [Homo sapiens] 544 e-155
gi|23397708 copine I isoform a [Homo sapiens] 531 e-151
gi|23397706 copine I isoform a [Homo sapiens] 531 e-151
gi|23397704 copine I isoform a [Homo sapiens] 531 e-151
gi|23397702 copine I isoform a [Homo sapiens] 531 e-151
gi|23397700 copine I isoform a [Homo sapiens] 531 e-151
gi|23397698 copine I isoform a [Homo sapiens] 531 e-151
gi|23397696 copine I isoform a [Homo sapiens] 531 e-151
gi|197333761 copine I isoform b [Homo sapiens] 531 e-151
gi|25121972 copine VIII [Homo sapiens] 494 e-139
gi|25141323 copine V [Homo sapiens] 482 e-136
gi|88703066 copine-like protein [Homo sapiens] 467 e-131
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 45 2e-04
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 45 2e-04
gi|38570146 synaptotagmin VII [Homo sapiens] 44 4e-04
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 44 5e-04
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 44 5e-04
gi|238550198 synaptotagmin III [Homo sapiens] 43 7e-04
gi|238550196 synaptotagmin III [Homo sapiens] 43 7e-04
gi|14150054 synaptotagmin III [Homo sapiens] 43 7e-04
gi|45504376 synaptotagmin VI [Homo sapiens] 42 0.001
gi|28376627 synaptotagmin IX [Homo sapiens] 42 0.001
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 42 0.002
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 42 0.002
gi|39752671 synaptotagmin X [Homo sapiens] 41 0.003
>gi|5174421 copine 6 [Homo sapiens]
Length = 557
Score = 1139 bits (2947), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MSDPEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERT 60
MSDPEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERT
Sbjct: 1 MSDPEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERT 60
Query: 61 EVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ 120
EVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ
Sbjct: 61 EVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ 120
Query: 121 TKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYK 180
TKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYK
Sbjct: 121 TKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYK 180
Query: 181 TNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIG 240
TNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIG
Sbjct: 181 TNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIG 240
Query: 241 EFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIM 300
EFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIM
Sbjct: 241 EFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIM 300
Query: 301 GGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAF 360
GGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAF
Sbjct: 301 GGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAF 360
Query: 361 GFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVA 420
GFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVA
Sbjct: 361 GFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVA 420
Query: 421 EPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMR 480
EPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMR
Sbjct: 421 EPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMR 480
Query: 481 LLDGDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGIS 540
LLDGDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGIS
Sbjct: 481 LLDGDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGIS 540
Query: 541 PGAPRPCTLATTPSPSP 557
PGAPRPCTLATTPSPSP
Sbjct: 541 PGAPRPCTLATTPSPSP 557
>gi|25141328 copine 7 isoform a [Homo sapiens]
Length = 558
Score = 723 bits (1867), Expect = 0.0
Identities = 354/524 (67%), Positives = 433/524 (82%), Gaps = 3/524 (0%)
Query: 19 ASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALE 78
AS+VELR+SC LLDRD LTK P V L + QWV+V RTEV+RS PVFS+V ++
Sbjct: 21 ASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVD 80
Query: 79 YFFEEKQPLQFHVFDAED-GATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGK 137
Y+FEE Q L+F V+D S + D FLG ECTLGQIV+Q KVT+PLLLK G+ AGK
Sbjct: 81 YYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQIVAQKKVTRPLLLKFGRNAGK 140
Query: 138 STITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVK 197
STIT++AE++SG N YV+L+FRA KLD+KDLFSKSDPF+E+Y+ N+DQ QLV+RTEVVK
Sbjct: 141 STITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVK 200
Query: 198 NNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPG 257
NNLNP WE F++SL SLCSC+ RPLK LV+DYDS GKHDFIGEF++TF+EMQ+ A
Sbjct: 201 NNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQK--AFEE 258
Query: 258 QEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASN 317
+ QWDC+NPKY+ K+++YK+SG VVLA +V++FLDYIMGGCQI FTVAIDFTASN
Sbjct: 259 GQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASN 318
Query: 318 GDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFA 377
GDPR+S SLH ++P QPN YL+AL +VG ICQDYDSDKRF A GFGARIPP +EVSHDFA
Sbjct: 319 GDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHDFA 378
Query: 378 INFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSV 437
INF+PE+ ECE I GV+ +Y+ CLP++QLYGPTNVAPII++VA A E+STG+A++Y +
Sbjct: 379 INFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQYYI 438
Query: 438 LLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPA 497
LL+LTDGVV+DMA+TR AIVRASRLPMSIIIVGVGNADF+DM++LDGDDG LR PRG PA
Sbjct: 439 LLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPA 498
Query: 498 ARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISP 541
RDIVQFVPFR+ K+A+P+ALAKCVLAEVP+QVVEYY+ +G+ P
Sbjct: 499 LRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPP 542
>gi|18677733 copine IV [Homo sapiens]
Length = 557
Score = 702 bits (1813), Expect = 0.0
Identities = 336/522 (64%), Positives = 426/522 (81%), Gaps = 3/522 (0%)
Query: 20 SRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEY 79
++VELRV+C G+ DRD L+KP PCV+LK+ S QW EV+RTEV+R+C +PV+S++ +++
Sbjct: 24 TKVELRVACKGISDRDALSKPDPCVILKMQSHGQWFEVDRTEVIRTCINPVYSKLFTVDF 83
Query: 80 FFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKST 139
+FEE Q L+F V D + FLG ECTLGQIVSQ K++K LL K+G TAGKS+
Sbjct: 84 YFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQRKLSKSLL-KHGNTAGKSS 142
Query: 140 ITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNN 199
IT++AEE+SG +DYV+L F A KLD+KD FSKSDPF+EI++ N+D + QLV RTEVV NN
Sbjct: 143 ITVIAEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTEVVMNN 202
Query: 200 LNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQE 259
L+P+W+ F++S++SLCS D R LK +V+D+DS+GKHDFIGEFTSTF+EM+ A G++
Sbjct: 203 LSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRG--AMEGKQ 260
Query: 260 MQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGD 319
+QW+CINPKY+ KKKNYK+SGTV+L C + K+H+FLDYIMGGCQI FTVAIDFTASNGD
Sbjct: 261 VQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTASNGD 320
Query: 320 PRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAIN 379
PR+S SLH + P QPN YL+AL AVG ICQDYDSDK FPAFGFGARIPP + VSHDFAIN
Sbjct: 321 PRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDFAIN 380
Query: 380 FDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLL 439
F+ +NPEC I GV+ +Y+ CLP++QLYGPTN+APII +VA+ A E +T +A++Y +LL
Sbjct: 381 FNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYFILL 440
Query: 440 VLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAAR 499
+LTDGV++DMA+TR AIV AS LPMS+IIVGVGNADFSDM++LDGDDG LR P+G P R
Sbjct: 441 ILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEPVLR 500
Query: 500 DIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISP 541
DIVQFVPFR+FK A+P+ALAK VLAEVP QVV+YY +GI P
Sbjct: 501 DIVQFVPFRNFKHASPAALAKSVLAEVPNQVVDYYNGKGIKP 542
>gi|7656993 copine 7 isoform b [Homo sapiens]
Length = 633
Score = 627 bits (1618), Expect = e-180
Identities = 301/426 (70%), Positives = 368/426 (86%), Gaps = 2/426 (0%)
Query: 116 QIVSQTKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPF 175
QIV+Q KVT+PLLLK G+ AGKSTIT++AE++SG N YV+L+FRA KLD+KDLFSKSDPF
Sbjct: 194 QIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPF 253
Query: 176 MEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGK 235
+E+Y+ N+DQ QLV+RTEVVKNNLNP WE F++SL SLCSC+ RPLK LV+DYDS GK
Sbjct: 254 LELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGK 313
Query: 236 HDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTF 295
HDFIGEF++TF+EMQ+ A + QWDC+NPKY+ K+++YK+SG VVLA +V++F
Sbjct: 314 HDFIGEFSTTFEEMQK--AFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSF 371
Query: 296 LDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDK 355
LDYIMGGCQI FTVAIDFTASNGDPR+S SLH ++P QPN YL+AL +VG ICQDYDSDK
Sbjct: 372 LDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDK 431
Query: 356 RFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPI 415
RF A GFGARIPP +EVSHDFAINF+PE+ ECE I GV+ +Y+ CLP++QLYGPTNVAPI
Sbjct: 432 RFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPI 491
Query: 416 INRVAEPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNAD 475
I++VA A E+STG+A++Y +LL+LTDGVV+DMA+TR AIVRASRLPMSIIIVGVGNAD
Sbjct: 492 ISKVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNAD 551
Query: 476 FSDMRLLDGDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYA 535
F+DM++LDGDDG LR PRG PA RDIVQFVPFR+ K+A+P+ALAKCVLAEVP+QVVEYY+
Sbjct: 552 FTDMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYS 611
Query: 536 SQGISP 541
+G+ P
Sbjct: 612 HRGLPP 617
Score = 102 bits (254), Expect = 9e-22
Identities = 54/99 (54%), Positives = 66/99 (66%), Gaps = 1/99 (1%)
Query: 19 ASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALE 78
AS+VELR+SC LLDRD LTK P V L + QWV+V RTEV+RS PVFS+V ++
Sbjct: 21 ASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVD 80
Query: 79 YFFEEKQPLQFHVFDAE-DGATSPRNDTFLGSTECTLGQ 116
Y+FEE Q L+F V+D S + D FLG ECTLGQ
Sbjct: 81 YYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQ 119
Score = 32.0 bits (71), Expect = 1.5
Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 4/76 (5%)
Query: 22 VELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVE-VERTEVLRSCSSPV---FSRVLAL 77
VEL L D+D +K P + L +D+Q ++ V RTEV+++ +PV F L+
Sbjct: 232 VELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSS 291
Query: 78 EYFFEEKQPLQFHVFD 93
EE +PL+ V+D
Sbjct: 292 LCSCEETRPLKCLVWD 307
Score = 30.8 bits (68), Expect = 3.4
Identities = 31/97 (31%), Positives = 51/97 (52%), Gaps = 9/97 (9%)
Query: 154 VQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHS 213
V+L L ++D +KSDP + + + + Q Q V RTEVV+++L+P + ++
Sbjct: 24 VELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQ-VGRTEVVRSSLHPVFS--KVFTVD 80
Query: 214 LCSCDVHRPLKFLVYD-YDSSG----KHDFIGEFTST 245
+V R L+F VYD + SG + DF+G T
Sbjct: 81 YYFEEVQR-LRFEVYDTHGPSGFSCQEDDFLGGMECT 116
>gi|4503015 copine III [Homo sapiens]
Length = 537
Score = 571 bits (1471), Expect = e-163
Identities = 286/523 (54%), Positives = 370/523 (70%), Gaps = 4/523 (0%)
Query: 20 SRVELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALE 78
++V L VSC LLD+D +K P CVL S +QW EVERTE +++C +P FS+ ++
Sbjct: 7 TKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFIID 66
Query: 79 YFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKS 138
Y+FE Q L+F V+D ++ +D FLG ECTLGQIVS K+T+PL++K G+ AGK
Sbjct: 67 YYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTGRPAGKG 126
Query: 139 TITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKN 198
+ITI AEE+ N V A KLDNKDLF KSDP++E +K D + +V RTEVVKN
Sbjct: 127 SITISAEEIKD-NRVVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTEVVKN 185
Query: 199 NLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQ 258
NLNP W PF++SL+SLC D+ + +K YDYD+ G HD IG F +T +++E A+
Sbjct: 186 NLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKE--ASRSS 243
Query: 259 EMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNG 318
++++CIN K R KKK+YK+SG + + QC + TFLDYIMGGCQ++FTV +DFT SNG
Sbjct: 244 PVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGSNG 303
Query: 319 DPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAI 378
DPRS SLH +SP N YL AL +VG + QDYD+DK FPAFGFGA+IPP ++VSH+F +
Sbjct: 304 DPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEFPM 363
Query: 379 NFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVL 438
NF+P NP C I G++ +YR CLPQI+LYGPTN +PIIN VA A A++Y VL
Sbjct: 364 NFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQYFVL 423
Query: 439 LVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAA 498
L++TDGV++D+ ETR AIV ASRLPMSIIIVGVG ADFS M LDGD G LR P G A
Sbjct: 424 LIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAI 483
Query: 499 RDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISP 541
RDIVQFVPFR F++A ALA+CVLAE+P+QVV Y+ + + P
Sbjct: 484 RDIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLP 526
>gi|30181236 copine II [Homo sapiens]
Length = 548
Score = 544 bits (1402), Expect = e-155
Identities = 275/543 (50%), Positives = 365/543 (67%), Gaps = 5/543 (0%)
Query: 4 PEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVL 63
P G P P + +VEL VS LLDRD +K P +L ++ +W+E +RTE
Sbjct: 10 PAAGAAPMGPQYCV--CKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETA 67
Query: 64 RSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKV 123
+ +P FS+ L+Y FEE Q L+F +FD + + FLG C+LG IVS K+
Sbjct: 68 INNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKI 127
Query: 124 TKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNE 183
T+PLLL N K AGK ITI A+E+S N + L+ +LD KDLF KSDPF+E YK +
Sbjct: 128 TRPLLLLNDKPAGKGLITIAAQELSD-NRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGD 186
Query: 184 DQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFT 243
D LV RTEV+K L+P W+PF + L SLC D+ +P++ + YDYD+ G HDFIGEF
Sbjct: 187 DGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQ 246
Query: 244 STFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGC 303
++ +M E A ++++CINPK + KKKNYK+SG ++L C + + ++FLDYI+GGC
Sbjct: 247 TSVSQMCE--ARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGC 304
Query: 304 QISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFG 363
Q+ FTV IDFTASNG+P SLH ++P N YL A+ AVG I QDYDSDK FPA GFG
Sbjct: 305 QLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFG 364
Query: 364 ARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPA 423
A++PP+++VSH+FAINF+P NP C + G+ +Y CLP I+ YGPTN +PI+N VA A
Sbjct: 365 AQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFA 424
Query: 424 QREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLD 483
+ AT+Y +LL++TDGV+SDM ETR A+V+AS+LPMSIIIVGVGNADF+ M LD
Sbjct: 425 AQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLD 484
Query: 484 GDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGA 543
GD LR G AARDIVQFVPFR+F++AA LAK VLAE+P+QVV+Y+ + + P
Sbjct: 485 GDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTN 544
Query: 544 PRP 546
P
Sbjct: 545 SEP 547
>gi|23397708 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|23397706 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|23397704 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|23397702 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|23397700 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|23397698 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|23397696 copine I isoform a [Homo sapiens]
Length = 537
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 8 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 67
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 68 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 127
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 128 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 185
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 186 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 239
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 240 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 299
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 300 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 359
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 360 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 419
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 420 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 479
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 480 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 535
>gi|197333761 copine I isoform b [Homo sapiens]
Length = 542
Score = 531 bits (1369), Expect = e-151
Identities = 273/537 (50%), Positives = 365/537 (67%), Gaps = 10/537 (1%)
Query: 22 VELRVSCHGLLDRDTLTKPHP-CVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYF 80
V+L +SC L+D+D +K P CVLL+ W E+ RTE +R+CSSP FS+ L LEY
Sbjct: 13 VQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYR 72
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
FE Q L+F ++D ++ R+D FLG EC+LGQIVS +T PL+LK GK AG+ TI
Sbjct: 73 FETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTI 132
Query: 141 TIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNL 200
T+ A+E+ N V + A LD KD KSDPF+E ++ D LV+R+EV+KNNL
Sbjct: 133 TVSAQELKD-NRVVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEVIKNNL 190
Query: 201 NPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEM 260
NP+W+ F + + C + P++ DYDS G HD IG F ++ ++Q A
Sbjct: 191 NPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPA------ 244
Query: 261 QWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP 320
+++CI+P+ + KKK+YK+SGT+ + C VE ++FLDY+MGGCQI+FTV +DFT SNGDP
Sbjct: 245 EFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDP 304
Query: 321 RSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINF 380
S SLH LSP N YL AL +VG + QDYDSDK FPAFGFGA++PP+++VSH+FA+NF
Sbjct: 305 SSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNF 364
Query: 381 DPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLV 440
+P NP C I G++ +YR+ LPQ++LYGPTN APIIN VA A + G A++Y +LL+
Sbjct: 365 NPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLL 424
Query: 441 LTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARD 500
LTDG V+D+ TR A+VRAS LPMS+IIVGVG ADF M LD D GPL G AARD
Sbjct: 425 LTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARD 484
Query: 501 IVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP 557
IVQFVP+R F++A ALA+ VLAEVP Q+V Y+ +QG +P P P + A P+ +P
Sbjct: 485 IVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPS-AKDPAQAP 540
>gi|25121972 copine VIII [Homo sapiens]
Length = 564
Score = 494 bits (1271), Expect = e-139
Identities = 272/544 (50%), Positives = 363/544 (66%), Gaps = 20/544 (3%)
Query: 19 ASRVELRVSCHGLLDRDTLTKPHP-CVL-LKLYSDEQWVEVERTEVLRSCSSPVFSRVLA 76
A+RVE+ VSC LLDRDT +K P CVL ++ +++W E RTEV+ + +P F R
Sbjct: 23 ATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFI 82
Query: 77 LEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ--TKVTKPLLLKNGKT 134
L+YFFEE++ L+F ++D + + + FLG CTLG+IV +++ KP++ GK
Sbjct: 83 LDYFFEERENLRFDLYDVDSKSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKK 142
Query: 135 AGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTE 194
G TI + AEE++ D V + F A KLD KD F KSDPF+ Y++NED S + +TE
Sbjct: 143 CG--TIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTE 200
Query: 195 VVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTA 254
VVKN LNP W+ F++S+ +LC+ D R +K VYD+D G HDFIGEFT++++E+ G +
Sbjct: 201 VVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQS 260
Query: 255 NPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFT 314
Q ++ +NPK + KKK Y +SGTV L VE +FLDYI GG QI+FTVAIDFT
Sbjct: 261 ---QFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFT 317
Query: 315 ASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSH 374
ASNG+P SLH ++P Q N Y AL+AVG I QDYDSDK FPA GFGA++PP+ +SH
Sbjct: 318 ASNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISH 377
Query: 375 DFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATK 434
+FA+N +P+NP C+ I GV+ +Y R L +QLYGPTN AP+IN VA A S ++
Sbjct: 378 EFALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYA---SSVKDGSQ 434
Query: 435 YSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRG 494
Y VLL++TDGV+SDMA+T+ +IV AS+LPMSIIIVGVG A+F M LDGDD + RG
Sbjct: 435 YFVLLIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRV-SSRG 493
Query: 495 VPAARDIVQFVPFRDFKD------AAPSALAKCVLAEVPRQVVEYYASQGISPG-APRPC 547
A RDIVQFVPFRD+ D + + LAK VLAE+P Q + Y ++GI P AP P
Sbjct: 494 KYAERDIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPY 553
Query: 548 TLAT 551
T T
Sbjct: 554 TPPT 557
>gi|25141323 copine V [Homo sapiens]
Length = 593
Score = 482 bits (1241), Expect = e-136
Identities = 272/570 (47%), Positives = 357/570 (62%), Gaps = 36/570 (6%)
Query: 16 TLGASRVELRVSCHGLLDRDTLTKPHP-CVLLKL-YSDEQWVEVERTEVLRSCSSPVFSR 73
++ A++VE+ VSC LLD+D +K P CV+ ++QW E RTEV+ + +P F R
Sbjct: 19 SIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVR 78
Query: 74 VLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ--TKVTKPLLL-- 129
++YFFEEKQ L+F ++D + + FLG CTLG+IV +++ KPL +
Sbjct: 79 KFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLGEIVGSPGSRLEKPLTIGA 138
Query: 130 --------------KNGKTAGKS--TITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSD 173
NG GK TI + AEE+S D + F A KLD KD F KSD
Sbjct: 139 FSLNSRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVATMQFCANKLDKKDFFGKSD 198
Query: 174 PFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSS 233
PF+ Y++NED + + +TEV+KN LNP W+ F + + +LC+ D R +K VYD+D
Sbjct: 199 PFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRD 258
Query: 234 GKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVH 293
G HDFIGEFT++++E+ G + Q ++ +NPK + KKK Y +SGTV L VE
Sbjct: 259 GSHDFIGEFTTSYRELARGQS---QFNIYEVVNPKKKMKKKKYVNSGTVTLLSFAVESEC 315
Query: 294 TFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDS 353
TFLDYI GG QI+FTVAIDFTASNG+P S SLH +SP Q N Y AL AVG I Q YDS
Sbjct: 316 TFLDYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDS 375
Query: 354 DKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVA 413
DK FPA GFGA++PP+ VSH+F +N + ENP C I G++ +Y R L +QLYGPTN A
Sbjct: 376 DKMFPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYHRSLRTVQLYGPTNFA 435
Query: 414 PIINRVAEPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGN 473
P++ VA A Q Q YSVLL++TDGV+SDMA+T+ AIV A++LPMSIIIVGVG
Sbjct: 436 PVVTHVARNAAAVQDGSQ---YSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQ 492
Query: 474 ADFSDMRLLDGDDGPLRCPRGVPAARDIVQFVPFRDFKD------AAPSALAKCVLAEVP 527
A+F M LDGDD + RG A RDIVQFVPFRD+ D + + LA+ VLAE+P
Sbjct: 493 AEFDAMVELDGDDVRI-SSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIP 551
Query: 528 RQVVEYYASQGISPGAPRPCTLATTPSPSP 557
Q+V Y +QGI P P P +PS SP
Sbjct: 552 DQLVSYMKAQGIRP-RPPPAAPTHSPSQSP 580
>gi|88703066 copine-like protein [Homo sapiens]
Length = 553
Score = 467 bits (1202), Expect = e-131
Identities = 255/547 (46%), Positives = 346/547 (63%), Gaps = 19/547 (3%)
Query: 19 ASRVELRVSCHGLLDRDTLTKPHPCVLLKLYS--DEQWVEVERTEVLRSCSSPVFSRVLA 76
A+++E+ VSC LLD DT +K P V+L S ++W E RTEV+ + +P F R
Sbjct: 13 ATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFV 72
Query: 77 LEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ--TKVTKPLLLKNGKT 134
L+YFFEEKQ L+F V++ + + FLG LG+++ ++V + L GK
Sbjct: 73 LDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKK 132
Query: 135 AGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTE 194
G TI + AEE+S D + A KLD KD F KSDPF+ Y++NED + + +TE
Sbjct: 133 CG--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTE 190
Query: 195 VVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTA 254
VVKN LNP W+PF + + +LC+ D R +K VYD+D G HDFIGEFT++++E+ +
Sbjct: 191 VVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQ- 249
Query: 255 NPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFT 314
Q ++ +NP+ + KKK Y +SGTV L +V+ TF+DYI GG Q++FTVAIDFT
Sbjct: 250 --NQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFT 307
Query: 315 ASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSH 374
ASNG+P SLH +SP Q + Y AL+AVG I QDYDSDK FPA+GFGA++PP +SH
Sbjct: 308 ASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISH 367
Query: 375 DFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATK 434
F +N + E+P C I GV+ SY + L +QLYGPT AP+IN+VA A + ++
Sbjct: 368 QFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAK---ISDGSQ 424
Query: 435 YSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRG 494
Y VLL++TDGV+SDM +T+ AIV AS LPMSIIIVGVG A F M LDGDD + RG
Sbjct: 425 YYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRV-SSRG 483
Query: 495 VPAARDIVQFVPFRDFKD------AAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCT 548
A RDIVQFVPFRD+ D + + LAK VLAE+P Q++ Y ++ I P P P
Sbjct: 484 RYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPAN 543
Query: 549 LATTPSP 555
+ P+P
Sbjct: 544 PSPIPAP 550
Score = 40.0 bits (92), Expect = 0.006
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 10/104 (9%)
Query: 144 AEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIY-KTNEDQSDQLVWRTEVVKNNLNP 202
A E S +++T L + D FSKSDP + +Y ++ Q + RTEV+ N LNP
Sbjct: 6 ASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNP 65
Query: 203 SW-EPFRLSLHSLCSCDVHRPLKFLVYDYDS----SGKHDFIGE 241
+ F L + + L+F VY+ DS S DF+G+
Sbjct: 66 DFVRKFVLDYF----FEEKQNLRFDVYNVDSKTNISKPKDFLGQ 105
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 44.7 bits (104), Expect = 2e-04
Identities = 25/85 (29%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 172 SDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSW-EPFRLSLHSLCSCDVHRPLKFLVYDY 230
SDP++++ K D + +T+ +K +LNP W E FR L D R L ++D+
Sbjct: 192 SDPYVKL-KLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKE---SDKDRRLSVEIWDW 247
Query: 231 DSSGKHDFIGEFTSTFQEMQEGTAN 255
D + ++DF+G + E+Q+ + +
Sbjct: 248 DLTSRNDFMGSLSFGISELQKASVD 272
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 44.7 bits (104), Expect = 2e-04
Identities = 25/85 (29%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 172 SDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSW-EPFRLSLHSLCSCDVHRPLKFLVYDY 230
SDP++++ K D + +T+ +K +LNP W E FR L D R L ++D+
Sbjct: 192 SDPYVKL-KLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKE---SDKDRRLSVEIWDW 247
Query: 231 DSSGKHDFIGEFTSTFQEMQEGTAN 255
D + ++DF+G + E+Q+ + +
Sbjct: 248 DLTSRNDFMGSLSFGISELQKASVD 272
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 43.9 bits (102), Expect = 4e-04
Identities = 37/124 (29%), Positives = 53/124 (42%), Gaps = 18/124 (14%)
Query: 159 RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCD 218
+A +L KD SDPF++IY D+ +L T+V + NLNP W L
Sbjct: 158 KAQELPAKDFSGTSDPFVKIYLL-PDKKHKL--ETKVKRKNLNPHWNETFLFEGFPYEKV 214
Query: 219 VHRPLKFLVYDYDSSGKHDFIGE---------------FTSTFQEMQEGTANPGQEMQWD 263
V R L V DYD ++D IGE F + +G+ + G+ +
Sbjct: 215 VQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSL 274
Query: 264 CINP 267
C NP
Sbjct: 275 CYNP 278
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 43.5 bits (101), Expect = 5e-04
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 12/95 (12%)
Query: 159 RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEP-FRLSLHSLCSC 217
RA L D+ KSDPF + N D+L+ T V NLNP W F ++
Sbjct: 413 RAEGLMAADVTGKSDPFCVVELNN----DRLL--THTVYKNLNPEWNKVFTFNIK----- 461
Query: 218 DVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEG 252
D+H L+ VYD D DF+G+ +Q G
Sbjct: 462 DIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNG 496
Score = 40.4 bits (93), Expect = 0.004
Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 159 RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCD 218
R L +D SDP+++ ++ V+R++++ NLNP WE L
Sbjct: 48 RGQSLAARDRGGTSDPYVKFKIGGKE-----VFRSKIIHKNLNPVWEEKACILVD----H 98
Query: 219 VHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRD 271
+ PL V+DYD + DF+G S F ++ + N ++ +P Y D
Sbjct: 99 LREPLYIKVFDYDFGLQDDFMG---SAFLDLTQLELNRPTDVTLTLKDPHYPD 148
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 43.5 bits (101), Expect = 5e-04
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 12/95 (12%)
Query: 159 RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEP-FRLSLHSLCSC 217
RA L D+ KSDPF + N D+L+ T V NLNP W F ++
Sbjct: 634 RAEGLMAADVTGKSDPFCVVELNN----DRLL--THTVYKNLNPEWNKVFTFNIK----- 682
Query: 218 DVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEG 252
D+H L+ VYD D DF+G+ +Q G
Sbjct: 683 DIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNG 717
Score = 40.4 bits (93), Expect = 0.004
Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 12/113 (10%)
Query: 159 RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCD 218
R L +D SDP+++ ++ V+R++++ NLNP WE L
Sbjct: 269 RGQSLAARDRGGTSDPYVKFKIGGKE-----VFRSKIIHKNLNPVWEEKACILVD----H 319
Query: 219 VHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRD 271
+ PL V+DYD + DF+G S F ++ + N ++ +P Y D
Sbjct: 320 LREPLYIKVFDYDFGLQDDFMG---SAFLDLTQLELNRPTDVTLTLKDPHYPD 369
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 6/111 (5%)
Query: 132 GKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVW 191
G A I+ + G++ V +A L KD SDP+++IY + + +
Sbjct: 295 GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK---F 351
Query: 192 RTEVVKNNLNPSW-EPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGE 241
+T+V + LNP + E F+ S+ L R L F VYD+D +HD IG+
Sbjct: 352 QTKVHRKTLNPVFNETFQFSV-PLAEL-AQRKLHFSVYDFDRFSRHDLIGQ 400
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 6/111 (5%)
Query: 132 GKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVW 191
G A I+ + G++ V +A L KD SDP+++IY + + +
Sbjct: 295 GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK---F 351
Query: 192 RTEVVKNNLNPSW-EPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGE 241
+T+V + LNP + E F+ S+ L R L F VYD+D +HD IG+
Sbjct: 352 QTKVHRKTLNPVFNETFQFSV-PLAEL-AQRKLHFSVYDFDRFSRHDLIGQ 400
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 6/111 (5%)
Query: 132 GKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVW 191
G A I+ + G++ V +A L KD SDP+++IY + + +
Sbjct: 295 GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKK---F 351
Query: 192 RTEVVKNNLNPSW-EPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGE 241
+T+V + LNP + E F+ S+ L R L F VYD+D +HD IG+
Sbjct: 352 QTKVHRKTLNPVFNETFQFSV-PLAEL-AQRKLHFSVYDFDRFSRHDLIGQ 400
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 42.0 bits (97), Expect = 0.001
Identities = 46/174 (26%), Positives = 70/174 (40%), Gaps = 31/174 (17%)
Query: 81 FEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTI 140
F+ P Q HV + G P ++G+I KP L K G+
Sbjct: 90 FKRHLPRQMHVSSVDYGNELPP----AAEQPTSIGRI-------KPELYKQKSVDGEDAK 138
Query: 141 TIVAEEVSGTN-----DYVQLTF-----RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLV 190
+ + N DY T +A+ L KD SDP+++IY D+ +L
Sbjct: 139 SEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLL-PDRKCKL- 196
Query: 191 WRTEVVKNNLNPSWEP---FRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGE 241
+T V + LNP+++ F + L R L V+D+D +HD IGE
Sbjct: 197 -QTRVHRKTLNPTFDENFHFPVPYEELAD----RKLHLSVFDFDRFSRHDMIGE 245
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 42.0 bits (97), Expect = 0.001
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 8/112 (7%)
Query: 131 NGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLV 190
N K GK + + + + +A L KD SDP+++IY + ++
Sbjct: 217 NSKACGK--LNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKH-- 272
Query: 191 WRTEVVKNNLNPSWEPFRLSLHSLCSCDVH-RPLKFLVYDYDSSGKHDFIGE 241
+T+V + LNP ++ + L + D+ R L F VYD+D +HD IG+
Sbjct: 273 -QTKVHRKTLNPVFD--EVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQ 321
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 15/94 (15%)
Query: 165 NKDLFSKSDP--FMEIYKTNEDQSDQLVWRTEVVKNN-LNPSWEP---FRLSLHSLCSCD 218
NK+ S DP +EI+ + D + + +T V+ NN NP W+ F + + L
Sbjct: 645 NKNKNSIVDPKVTVEIHGVSRDVASR---QTAVITNNGFNPWWDTEFAFEVVVPDLAL-- 699
Query: 219 VHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEG 252
++FLV DYD+S K+DFIG+ T +++G
Sbjct: 700 ----IRFLVEDYDASSKNDFIGQSTIPLNSLKQG 729
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 15/94 (15%)
Query: 165 NKDLFSKSDP--FMEIYKTNEDQSDQLVWRTEVVKNN-LNPSWEP---FRLSLHSLCSCD 218
NK+ S DP +EI+ + D + + +T V+ NN NP W+ F + + L
Sbjct: 666 NKNKNSIVDPKVTVEIHGVSRDVASR---QTAVITNNGFNPWWDTEFAFEVVVPDLAL-- 720
Query: 219 VHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEG 252
++FLV DYD+S K+DFIG+ T +++G
Sbjct: 721 ----IRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 10/86 (11%)
Query: 159 RAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEP---FRLSLHSLC 215
+A L KD SDP++++Y + + ++T V + LNP ++ F ++ L
Sbjct: 254 KALDLPAKDFTGTSDPYVKMYLLPDRKKK---FQTRVHRKTLNPLFDETFQFPVAYDQLS 310
Query: 216 SCDVHRPLKFLVYDYDSSGKHDFIGE 241
+ R L F VYD+D +HD IGE
Sbjct: 311 N----RKLHFSVYDFDRFSRHDMIGE 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,299,116
Number of Sequences: 37866
Number of extensions: 1077025
Number of successful extensions: 2752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 2518
Number of HSP's gapped (non-prelim): 194
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.