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Search of human proteins with 51093861
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51093861 caspase recruitment domain protein 10 [Homo
sapiens]
(1032 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51093861 caspase recruitment domain protein 10 [Homo sapiens] 2060 0.0
gi|157743265 caspase recruitment domain family, member 11 [Homo ... 505 e-143
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom... 304 2e-82
gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo... 285 2e-76
gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo... 283 8e-76
gi|16507955 caspase recruitment domain protein 14 isoform 2 [Hom... 100 1e-20
gi|148746195 trichohyalin [Homo sapiens] 72 3e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 70 8e-12
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 69 2e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 67 9e-11
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 66 2e-10
gi|62243374 MAD1-like 1 protein [Homo sapiens] 65 4e-10
gi|62243369 MAD1-like 1 protein [Homo sapiens] 65 4e-10
gi|62243332 MAD1-like 1 protein [Homo sapiens] 65 4e-10
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 64 7e-10
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 64 1e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 62 2e-09
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 62 3e-09
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 62 3e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 62 4e-09
gi|16262452 cingulin [Homo sapiens] 62 4e-09
gi|42794779 myosin 18A isoform b [Homo sapiens] 62 4e-09
gi|28416946 myosin 18A isoform a [Homo sapiens] 62 4e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 61 5e-09
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 61 6e-09
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 61 6e-09
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 61 6e-09
gi|50083293 coiled-coil domain containing 123 [Homo sapiens] 61 6e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 60 8e-09
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 60 8e-09
>gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]
Length = 1032
Score = 2060 bits (5338), Expect = 0.0
Identities = 1032/1032 (100%), Positives = 1032/1032 (100%)
Query: 1 MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQ 60
MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQ
Sbjct: 1 MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQ 60
Query: 61 DEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRC 120
DEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRC
Sbjct: 61 DEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRC 120
Query: 121 SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ 180
SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ
Sbjct: 121 SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ 180
Query: 181 AQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK 240
AQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK
Sbjct: 181 AQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK 240
Query: 241 VSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG 300
VSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG
Sbjct: 241 VSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG 300
Query: 301 LQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM 360
LQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM
Sbjct: 301 LQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM 360
Query: 361 EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR 420
EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR
Sbjct: 361 EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR 420
Query: 421 KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLS 480
KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLS
Sbjct: 421 KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLS 480
Query: 481 EFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP 540
EFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP
Sbjct: 481 EFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP 540
Query: 541 APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAI 600
APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAI
Sbjct: 541 APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAI 600
Query: 601 RVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGA 660
RVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGA
Sbjct: 601 RVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGA 660
Query: 661 CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERAD 720
CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERAD
Sbjct: 661 CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERAD 720
Query: 721 PHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCL 780
PHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCL
Sbjct: 721 PHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCL 780
Query: 781 PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPL 840
PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPL
Sbjct: 781 PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPL 840
Query: 841 LVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPA 900
LVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPA
Sbjct: 841 LVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPA 900
Query: 901 TPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGR 960
TPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGR
Sbjct: 901 TPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGR 960
Query: 961 PGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVEC 1020
PGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVEC
Sbjct: 961 PGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVEC 1020
Query: 1021 GSSRGCPSSSEA 1032
GSSRGCPSSSEA
Sbjct: 1021 GSSRGCPSSSEA 1032
>gi|157743265 caspase recruitment domain family, member 11 [Homo
sapiens]
Length = 1154
Score = 505 bits (1301), Expect = e-143
Identities = 401/1167 (34%), Positives = 571/1167 (48%), Gaps = 204/1167 (17%)
Query: 23 EEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLM 82
EEDALWE +E RH L+R +NPAKLTPYLRQC+VIDEQDE+EVL+ P ++NR GRL+
Sbjct: 18 EEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLL 77
Query: 83 DILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRR 142
DIL +G+RGY FLE+LEFYYPE + L+TG+EP +R S I+ EEG EGLT FLM EV +
Sbjct: 78 DILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIK 137
Query: 143 LREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRL 202
L++ K++ + +L AR R LE+E+ + + QER +++E+ ++ + EL+++
Sbjct: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEERDSYNDELVKV 197
Query: 203 KDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAE 262
KD+NY +AMR AQLSEEKN AV+RSRDLQL +DQLK +++++EEEC L R
Sbjct: 198 KDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLERNQSLKLKNDI 257
Query: 263 EKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILE 322
E +KE+ V EL EN+ L +ELQ +Q A + P S++ +LDILE
Sbjct: 258 ENRPKKEQ---------VLELERENEMLKTKNQELQSIIQ--AGKRSLPDSDKAILDILE 306
Query: 323 HDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMA 382
HD +EA + RQEL +++ +Q E + AEELRD+YL+E EDL LK TL KDC++YKHRM
Sbjct: 307 HDRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMN 366
Query: 383 TVLAQLEEIEKERDQAIQS--------------RDRIQLQYSQSLIEKDQYRKQVRGLEA 428
TV+ QLEE+E+ERDQA S +D+ + Q + + D+ R ++ EA
Sbjct: 367 TVMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREA 426
Query: 429 ----------------------------------------------ERDELLTTLTSLEG 442
E D+ T+ S E
Sbjct: 427 CIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPED 486
Query: 443 TKALLE------------VQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPE 490
+K L +QLQRA+ LK + + T PS G
Sbjct: 487 SKYFLPYHPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGT---DASPSSCGSLP 543
Query: 491 ATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSM 550
T M P +S +SI PP SI+RR +E+ AP + +
Sbjct: 544 ITNSFTKMQPPRSRSSI-----------MSITAEPPGNDSIVRRYKED--APHRSTVEED 590
Query: 551 SDITGSVTL-------KPWSPGLSSSSSSDSVWPLGKPEGLLA---RGCGLDFLNRSL-- 598
+D G L + +S G SS SS S + EGL A L F SL
Sbjct: 591 NDSGGFDALDLDDDSHERYSFGPSSIHSSSSSH---QSEGLDAYDLEQVNLMFRKFSLER 647
Query: 599 ----AIRVSGRSPPGGPEPQDKGPDG------LSFYGDRWSGAVVRRVLSGPGSARMEPR 648
++ G GP Q +G L+ G G+ V V G + + R
Sbjct: 648 PFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLR 707
Query: 649 EQRVEAAGLEGACLEAEAQQRTL--------LWN-QGSTLPSLMDSKAC-QSFHEALEAW 698
E + LEG C+ E Q L W Q + P + K + + + ++
Sbjct: 708 EGH-QLLLLEG-CIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDM 765
Query: 699 AKG--PGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLR 756
G + FYIR NL + + D + +K +++ + D+ Y+ R EW C RVDP T
Sbjct: 766 EDGLITSGDSFYIRLNLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDH 825
Query: 757 DLDRGTVPNYQRAQQLLEVQ-----------------------------EKCLPSSRHR- 786
DLD GT+P+Y RAQQLL V+ E+ L +S R
Sbjct: 826 DLDMGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRV 885
Query: 787 GPR------------------SNLKKR--ALDQLRLVRPKPVGAPAGDSPD--QLLLEPC 824
PR N KR + +++R++ P+G+ A S D +LL E
Sbjct: 886 SPRLSRASFLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQ 945
Query: 825 AE--PER------SLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVC 876
E PE SL PYSLVR RPV+ P LA L++ LL+ ++F +C
Sbjct: 946 EELDPESELGKNLSLIPYSLVRAFYCERRRPVLFTPTVLAKTLVQRLLN-SGGAMEFTIC 1004
Query: 877 PAESLSGEE-LCPSSAPGAPKAQPATPGLGSRIRAIQ-ESVG--KKHCLLELGARGVREL 932
++ ++ +E L ++ P I E+V KHCLLE G R+L
Sbjct: 1005 KSDIVTRDEFLRRQKTETIIYSREKNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDL 1064
Query: 933 VQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAH 992
+++ IYPIV+ + V EKN++ R LL RP + E LR CR E+ L LPC + V
Sbjct: 1065 IKSNIYPIVLFIRVCEKNIKRFRKLLPRPE-TEEEFLRVCRLKEKELEALPCLYATVEPD 1123
Query: 993 EWGHAEELAKVVRGRILQEQARLVWVE 1019
WG EEL +VV+ +I +EQ + +WV+
Sbjct: 1124 MWGSVEELLRVVKDKIGEEQRKTIWVD 1150
>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
sapiens]
Length = 1004
Score = 304 bits (779), Expect = 2e-82
Identities = 302/1056 (28%), Positives = 470/1056 (44%), Gaps = 129/1056 (12%)
Query: 23 EEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLM 82
+E+ LWE +E RHR+ R + P++LTPYLRQ +V+ + DEEEVL + R R G L+
Sbjct: 15 DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74
Query: 83 DILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRR 142
D+L+ RGK G AFLE+L+F+ P+ +TL+TG +P S LT+ L +
Sbjct: 75 DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134
Query: 143 LREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRL 202
L+E + +++ L R + L+E E R Q + R++ + A E+LRL
Sbjct: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRL 194
Query: 203 KDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSR--LEEECALLRRARGPPPG 260
KDE +++ + +EK A R R LQ + LK ++ R + C L + +
Sbjct: 195 KDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTA 254
Query: 261 AEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDI 320
++++ ++E ++ L+ EN++L + L E DI
Sbjct: 255 SDQESGDEE----------LNRLKEENEKLRSLTFSLAE------------------KDI 286
Query: 321 LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHR 380
LE EA+ SRQEL +++H+++ AE R+QY +E E L+ + + C LY+ +
Sbjct: 287 LEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREK 346
Query: 381 MATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL 440
+ + AQ+ E++KERDQA +RD Q + SQSL+EKD R+QV L + EL T L L
Sbjct: 347 VNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQL 406
Query: 441 --EGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVM 498
E L + R + H++C S SL ++ E+ ++
Sbjct: 407 QAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSL----------VSSTESQLL 456
Query: 499 GGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDI-TGSV 557
+S E DS + S P PPS S+ +R E+ P SFSS +I G
Sbjct: 457 SDLSATSSRELVDSFR-----SSSPAPPSQQSLYKRVAEDFGEEP-WSFSSCLEIPEGDP 510
Query: 558 TLKPWS-----------------PGLSSSSSSDSVWPLGKPEG--LLARGCGLDFLNRSL 598
P + P L SS S L E L+ R L++
Sbjct: 511 GALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRILSQVT 570
Query: 599 AIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPRE-QRVEAAGL 657
+ G D + +S G +G + RV G + +M R ++
Sbjct: 571 MLAFQG----------DALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDY 620
Query: 658 EGA--CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAK---------GPGAEP 706
E + +A + TL + L +D C S + + + +
Sbjct: 621 EASEPLFKAVLEDTTL--EEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDS 678
Query: 707 FYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRD-LDRGTVPN 765
FYIR NL + RA L V E+L + D+ ++ W RV+ T++D GT+PN
Sbjct: 679 FYIRVNLAMEGRAKGE-LQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPN 737
Query: 766 YQRAQQLL-----EVQEKCL----PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSP 816
Y RAQQ L ++ ++C PSS GP+ ++ ++D K +P S
Sbjct: 738 YSRAQQQLIALIQDMTQQCTVTRKPSS--GGPQKLVRIVSMD-------KAKASPLRLSF 788
Query: 817 DQLLLEPC----------AEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDL 866
D+ L+P AE +L PY+LV P + RPV+L+P + L L L
Sbjct: 789 DRGQLDPSRMEGSSTCFWAESCLTLVPYTLVWPHRPARPRPVLLVPRAVGKILSEKLCLL 848
Query: 867 PSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRI-RAIQESVGKK--HCLLE 923
F+ C AE LS EE S G + G + R ES+ +K H LL+
Sbjct: 849 QG----FKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLD 904
Query: 924 LGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLP 983
+ V L + +I+PIVIHV V EK ++++ L R G + +LL R E L P
Sbjct: 905 VQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAP 964
Query: 984 CSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVE 1019
C + + W + L VR I EQ ++VW E
Sbjct: 965 CLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTE 1000
>gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo
sapiens]
Length = 536
Score = 285 bits (728), Expect = 2e-76
Identities = 185/528 (35%), Positives = 286/528 (54%), Gaps = 35/528 (6%)
Query: 24 EDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMD 83
+D W +EG R L ++P+++TPYLRQC+V++ DEE+VLS R + G L+D
Sbjct: 7 DDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLD 66
Query: 84 ILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRL 143
IL+ G +GY AFLE+LE YYP+ + +TG+EPA+ SMI+D G GLTQ LMTEV +L
Sbjct: 67 ILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKL 126
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQ--QQAQERCQRLREDWEAGSLELLR 201
+ ++ Q L A + ++ E R++D ++ QER QRL+E+ EAGS EL R
Sbjct: 127 Q-------KKVQDLTA--LLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
Query: 202 LKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGA 261
K+ENY +AMRLA SEEK +A++R+RDLQL +DQLK + + E++C + R+
Sbjct: 178 CKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERK-------- 229
Query: 262 EEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDIL 321
K + ++ + +L+ EL+ E L A ++EL+ +Q+ +P + +L
Sbjct: 230 -HTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSP-----YIQVL 283
Query: 322 EHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381
E DWR+A QE + +++ +L+ E R + ++E E L+ L+KD +YK R+
Sbjct: 284 EEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRI 343
Query: 382 ATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLE 441
+L Q+EE+ ERDQAI +R+ + Q+++ L EKD RKQVR L + DEL + E
Sbjct: 344 EAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCE 403
Query: 442 GTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGP 501
+E +L+R Q L+ S L P L + + + + GG
Sbjct: 404 AQLLAVEGRLRRQQ----LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGG 459
Query: 502 EPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSS 549
P A E+ +L P AG E++ K SF +
Sbjct: 460 SPKQPFAALHQEQ------VLRNPHDAGLSSGEPPEKERRRLKESFEN 501
>gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo
sapiens]
Length = 492
Score = 283 bits (723), Expect = 8e-76
Identities = 177/493 (35%), Positives = 274/493 (55%), Gaps = 29/493 (5%)
Query: 24 EDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMD 83
+D W +EG R L ++P+++TPYLRQC+V++ DEE+VLS R + G L+D
Sbjct: 7 DDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLD 66
Query: 84 ILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRL 143
IL+ G +GY AFLE+LE YYP+ + +TG+EPA+ SMI+D G GLTQ LMTEV +L
Sbjct: 67 ILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKL 126
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQ--QQAQERCQRLREDWEAGSLELLR 201
+ ++ Q L A + ++ E R++D ++ QER QRL+E+ EAGS EL R
Sbjct: 127 Q-------KKVQDLTA--LLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
Query: 202 LKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGA 261
K+ENY +AMRLA SEEK +A++R+RDLQL +DQLK + + E++C + R+
Sbjct: 178 CKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERK-------- 229
Query: 262 EEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDIL 321
K + ++ + +L+ EL+ E L A ++EL+ +Q+ +P + +L
Sbjct: 230 -HTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSP-----YIQVL 283
Query: 322 EHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381
E DWR+A QE + +++ +L+ E R + ++E E L+ L+KD +YK R+
Sbjct: 284 EEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRI 343
Query: 382 ATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLE 441
+L Q+EE+ ERDQAI +R+ + Q+++ L EKD RKQVR L + DEL + E
Sbjct: 344 EAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCE 403
Query: 442 GTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGP 501
+E +L+R Q L+ S L P L + + + + GG
Sbjct: 404 AQLLAVEGRLRRQQ----LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGG 459
Query: 502 EPHNSEEATDSEK 514
P A E+
Sbjct: 460 SPKQPFAALHQEQ 472
>gi|16507955 caspase recruitment domain protein 14 isoform 2 [Homo
sapiens]
Length = 434
Score = 99.8 bits (247), Expect = 1e-20
Identities = 78/237 (32%), Positives = 117/237 (49%), Gaps = 18/237 (7%)
Query: 319 DILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYK 378
DILE EA+ SRQEL +++H+++ AE R+QY +E E L+ + + C LY+
Sbjct: 48 DILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYR 107
Query: 379 HRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLT 438
++ + AQ+ E++KERDQA +RD Q + SQSL+EKD R+QV L + EL T L
Sbjct: 108 EKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLR 167
Query: 439 SL--EGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAA 496
L E L + R + H++C S SL ++ E+
Sbjct: 168 QLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSL----------VSSTESQ 217
Query: 497 VMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDI 553
++ +S E DS + S P PPS S+ +R E+ P SFSS +I
Sbjct: 218 LLSDLSATSSRELVDSFR-----SSSPAPPSQQSLYKRVAEDFGEEP-WSFSSCLEI 268
Score = 32.0 bits (71), Expect = 3.1
Identities = 54/226 (23%), Positives = 86/226 (38%), Gaps = 28/226 (12%)
Query: 180 QAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKL 239
+ QE+ R D E+G EL RLK+EN + L+E+ L+ ++D+ +
Sbjct: 8 ELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKD--------ILEQSLDEARG 59
Query: 240 KVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSE------LRAENQRLTAS 293
L E LR AE + ++ +EKE + R + L A
Sbjct: 60 SRQELVERIHSLRER---AVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQ 116
Query: 294 LRELQEGLQQEASRPGAPGSE----RILLDILEHDWREAQDSRQELCQKLHAVQGE---- 345
+ ELQ+ Q S + E + D L E D EL +L +Q E
Sbjct: 117 VCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGV 176
Query: 346 LQWAEELRDQYLQEMEDLRLKHRTLQK---DCDLYKHRMATVLAQL 388
L+ R+ +E + L H + DC L + +L+ L
Sbjct: 177 LKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDL 222
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.0 bits (175), Expect = 3e-12
Identities = 91/349 (26%), Positives = 152/349 (43%), Gaps = 40/349 (11%)
Query: 114 QEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQ 173
+E QR + +EE E L + E+RR R+ + Q QR ++ Q R EEER ++
Sbjct: 262 EEEPQRQRELQEEE--EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 174 RLRDQQQAQE-----RCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSR 228
R+QQ+ +E R Q+LR + E + LR + E +L + EE+ R
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 229 DLQLAVDQLKLKVSRLEEECAL-----------------LRRARGPPPGAEEKEKEKEKE 271
+ QL +Q + +L E L LRR + EE+ E++ E
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 272 KEPDNVDLVSELRAEN---QRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREA 328
+E L E +R + R QE +Q+ R L + E + RE
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 329 QDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDL---YKHRMATVL 385
Q+ R+ Q+L Q EE R+Q L+ E+ + L+ + L + R +L
Sbjct: 500 QERRE---QQLRREQ------EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 386 AQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELL 434
+ EE E+++ Q R Q + L+++++ R+Q R L+ E++E L
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR-LKREQEERL 598
Score = 67.8 bits (164), Expect = 5e-11
Identities = 92/342 (26%), Positives = 154/342 (45%), Gaps = 30/342 (8%)
Query: 111 LTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAG 170
L ++ +R + E+ E Q L E E R+ QL+REQQL+ ++ E++
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEE--ERREQQLRREQQLRREQQLRREQQLR 396
Query: 171 LEQRLRDQQQAQERCQRLREDWEAGSLELLR---------LKDENYMIAMRLAQLSEEKN 221
EQ+LR +QQ + R Q+LR + + + LR K E RL + EE+
Sbjct: 397 REQQLRREQQLR-REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 222 SAVLRSRDLQL-AVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLV 280
+ R + + ++ K ++ R +EE RR R EE+E+ +++E+ +
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEE---ERRERWLK--LEEEERREQQERREQQLRRE 510
Query: 281 SELRAENQRLTASLRE--LQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQK 338
E R E QRL E LQ+ L+ E R L E + R Q+ R+ Q+
Sbjct: 511 QEERRE-QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE---QR 566
Query: 339 LHAVQGE-----LQWAEELRDQYLQEMEDLRLKHRTLQKDCD-LYKHRMATVLAQLEEIE 392
L Q E L+ EE R Q L+ ++ RL+ R +++ + L + + EE E
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626
Query: 393 KERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELL 434
+ER Q + + + + Q L + Q R++ R E +E L
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Score = 63.2 bits (152), Expect = 1e-09
Identities = 85/328 (25%), Positives = 142/328 (43%), Gaps = 34/328 (10%)
Query: 115 EPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVL-EEERAGLEQ 173
E +R L E PE + + + E R+ QL+REQQ + R+ EEE LEQ
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670
Query: 174 RLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLA 233
RL+ + + + R Q L E+ + + E R+K +L ++ + S V Q
Sbjct: 671 RLKREHEEERREQELAEEEQEQARE--RIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 234 VDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAE------N 287
R +E+ RR EE+ +++++E D + +AE
Sbjct: 729 -------QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 288 QRLTA--SLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGE 345
QRL+A LRE +E +Q + +R L + E + R Q R+E ++L ++ E
Sbjct: 782 QRLSARPPLREQRE--RQLRAEERQQREQRFLPEEEEKEQRRRQ--RREREKELQFLEEE 837
Query: 346 LQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI 405
Q R Q LQE ED + + ++ + + R QLEE K R + ++ +
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQE--QRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 406 QLQYSQSLIEKDQYRKQVRGLEAERDEL 433
Q +Q RK+ + L+ E +EL
Sbjct: 896 Q----------EQLRKEQQLLQEEEEEL 913
Score = 60.8 bits (146), Expect = 6e-09
Identities = 86/357 (24%), Positives = 151/357 (42%), Gaps = 57/357 (15%)
Query: 114 QEPAQRCSMILDEEGPEGLTQFLMTEVRRLREA---RKSQLQREQQLQARGRVLEEERAG 170
QE +R + E+ E Q L E + RE R+ QL+REQQL+ ++ E++
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 171 LEQRLRDQQQA---------------QERCQRL------REDWEAGSLELLRLKDENYMI 209
EQ+LR +QQ + R QRL R DW E R + E
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 210 AMRLAQ----------LSEEKNSAVLRSRDLQLAVDQLKLKVSRL---EEECALLRRARG 256
++ Q L EE+ R+ QL +Q + + RL EEE L +R R
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR- 533
Query: 257 PPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASL-RELQEGLQQEASRPGAPGSER 315
+E++ + +++E+ + E R E +R L RE +E Q R +R
Sbjct: 534 ----SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 316 ILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCD 375
+ + Q+ R E Q+L + E EE R+Q L+ E + + L K +
Sbjct: 590 L---------KREQEERLE--QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638
Query: 376 LYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDE 432
+ R + + +E ++R + + +R++ + + E ++ R++ E E+++
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKR---EHEEERREQELAEEEQEQ 692
Score = 59.7 bits (143), Expect = 1e-08
Identities = 72/292 (24%), Positives = 140/292 (47%), Gaps = 30/292 (10%)
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLK 203
+ A + QL++EQQL L+EE L++ R++++ QE+ ++ RE+ E L+ +
Sbjct: 892 KPALQEQLRKEQQL------LQEEEEELQREEREKRRRQEQERQYREE------EQLQQE 939
Query: 204 DENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEE 263
+E + R + +E+ + + LQ +QL L EE RR E
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQL------LGEEPEKRRRQE------RE 987
Query: 264 KEKEKEKEKEPDNVDLVSELRAENQRLTASLR-ELQEGLQQEASRPGAPGSERILLDILE 322
K+ +E+E + + L+ E R + +R + ++ LQQE + E+ L E
Sbjct: 988 KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Query: 323 HDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMA 382
+RE ++ +QE ++L + E + +EL QY +E E+L+ + L ++ + R
Sbjct: 1048 RQYREEEELQQEE-EQLLGEERETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRRQE 1105
Query: 383 TVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELL 434
EE E ++++ R+ + + Q L + QYR++ ++ E ++LL
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQEL--ERQYREE-EEVQQEEEQLL 1154
Score = 59.3 bits (142), Expect = 2e-08
Identities = 80/331 (24%), Positives = 137/331 (41%), Gaps = 30/331 (9%)
Query: 142 RLREARKSQLQREQQL--QARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLEL 199
R +E + L+ EQQL Q R R +E L ++ R QQ+ Q+R ++ RE+ E
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE------EQ 1562
Query: 200 LRLKDENYMIAM----RLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRAR 255
LR + E ++ R +L E+K + R QL+ + + + R+ R
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Query: 256 GPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRE------------LQEGLQQ 303
+E+E+++ +E D L E + Q LR LQEG +Q
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 304 EASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDL 363
+ R R L RE + ++E + ++ + + E+LR + QE
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Query: 364 RLKHRTLQKDCDLYKHRMATVLAQLEEIEK--ERDQAIQSRDRIQLQYSQSLIEKDQYRK 421
+ ++R + ++ L R L + E K E +Q Q R+ QL+ +S D+ +
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES----DRKFR 1798
Query: 422 QVRGLEAERDELLTTLTSLEGTKALLEVQLQ 452
+ L ER+E +G E QLQ
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Score = 56.2 bits (134), Expect = 2e-07
Identities = 81/338 (23%), Positives = 147/338 (43%), Gaps = 28/338 (8%)
Query: 114 QEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQ------REQQLQARGRVLEEE 167
QE ++ +L EE E R RE R+ Q Q EQ Q ++L EE
Sbjct: 896 QEQLRKEQQLLQEEEEE--------LQREEREKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 168 RAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRS 227
R ++ R++Q +++ + +E+ G R + E +L +E+ +
Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 228 RDLQLAVD---QLKLKVSRLEEECALLRRARGPPPGAE-EKEKEKEKEKEPDNVDLVSEL 283
R+ + + Q + K +EE LLR R E E++ +E+E + + L+ E
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 284 R--AENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHA 341
R Q L R+ +E LQQE + E+ E RE ++ +QE Q L
Sbjct: 1068 RETRRRQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Query: 342 VQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHR-MATVLAQLEEIEKERDQAIQ 400
+ E + +EL QY +E E + + + L+++ + + + + + EE+++E +Q ++
Sbjct: 1127 -EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 401 S-----RDRIQLQYSQSLIEKDQYRKQVRGLEAERDEL 433
R + QY + + Q RKQ E +R +L
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Score = 55.5 bits (132), Expect = 3e-07
Identities = 90/357 (25%), Positives = 160/357 (44%), Gaps = 39/357 (10%)
Query: 114 QEPAQRC----SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERA 169
+E RC S++ D E +F + R+L E + ++++Q Q R EE++
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRD-RQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 170 GLEQRL--RDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRS 227
++RL RD+Q+ E R R++W+ R +E + + + + E + LR
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREE---RRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 228 RDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAEN 287
R+L L+L+ EE+ RR R EE+EKE K + + LR E
Sbjct: 213 REL------LELRRKGREEK-QQQRRERQDRVFQEEEEKEWRKRE--------TVLRKEE 257
Query: 288 QRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSR-QELCQKLHAVQGEL 346
++L + Q LQ+E + + + + E + ++ + R Q+L +K + E
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 347 QWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKE----RDQAIQSR 402
Q EE R+Q QE + + + R Q + + R + + EE +E R+Q + R
Sbjct: 318 Q--EERREQ--QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 403 DRIQLQYSQSLIEKDQYRKQV---RGLEAERDELLTTLTSLEGTKAL-LEVQLQRAQ 455
++ QL+ Q L + Q R++ R + R++ L L + L E QL+R Q
Sbjct: 374 EQ-QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Score = 55.5 bits (132), Expect = 3e-07
Identities = 80/313 (25%), Positives = 139/313 (44%), Gaps = 48/313 (15%)
Query: 130 EGLTQFLMTEVRRLREARKSQLQREQQL---QARGRVLEEERAGLEQRLRDQQQAQERCQ 186
EG Q R+ RE + +RE+Q Q R R EE L ++ R+QQ +R +
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDR 1667
Query: 187 RLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEE 246
+ RE+ +LL+ +E QL ++ R + QL + + K + E+
Sbjct: 1668 KFREE-----EQLLQEGEEQ--------QLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 247 ECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEAS 306
+ LRR EE++ +E E+E +LR + +R L E E L+ E
Sbjct: 1715 Q---LRRQELERKFREEEQLRQETEQE--------QLRRQ-ERYRKILEE--EQLRPERE 1760
Query: 307 RPGAPGSERILLDILEHDWREAQDSRQEL-CQKLHAVQGELQWAEELRDQYLQEMEDLRL 365
ER + +RE + RQE Q+L + + + ++ EE +Q QE E+ +L
Sbjct: 1761 EQQLRRQER------DRKFREEEQLRQEREEQQLRSQESDRKFREE--EQLRQEREEQQL 1812
Query: 366 KHRTLQKDCDLYKHRMATVLAQLEE----IEKERDQAIQSRDRIQLQYSQSLIEKDQYRK 421
R Q+D K+R QLEE + +ERD+ ++ ++ Q E++ +++
Sbjct: 1813 --RPQQRD---GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 422 QVRGLEAERDELL 434
+ + ER+ L
Sbjct: 1868 EEQKRRQERERKL 1880
Score = 53.9 bits (128), Expect = 8e-07
Identities = 81/333 (24%), Positives = 140/333 (42%), Gaps = 58/333 (17%)
Query: 121 SMILDEEGPEGLTQFLMTEVRRLREARK-------------SQLQREQQLQA--RGRVLE 165
S + D + + L L + R RE + QL+RE+Q +A R R +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 166 EERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVL 225
EE+ L + ++++ QE ++ RE+ +LL+ ++E L ++
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREE-----EQLLQEREEQ--------PLRRQERDRKF 1362
Query: 226 RSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRA 285
R +L+ K LEEE L R+ R EE++ ++ ++ D + R
Sbjct: 1363 REEELRHQEQGRKF----LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 286 ENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGE 345
E Q+L S +E ++E + ER L+ E Q RQE +K +
Sbjct: 1419 EEQQL--SRQERDRKFREEEQQVRRQERERKFLE-------EEQQLRQERHRKFREEEQL 1469
Query: 346 LQWAEEL------RD-QYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQA 398
LQ EE RD ++L+E + LR + R D + + + + + +E+E+
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQER----DRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 399 IQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERD 431
Q R R LQ E+ Q R+Q RG + +D
Sbjct: 1526 RQQRQRKFLQ------EEQQLRRQERGQQRRQD 1552
Score = 51.2 bits (121), Expect = 5e-06
Identities = 79/312 (25%), Positives = 142/312 (45%), Gaps = 42/312 (13%)
Query: 140 VRRLREARKSQLQREQQLQARGRVLEEERAGL-EQRLRDQQQAQERCQRLREDWEAGSLE 198
+R RE R+ Q +RE+Q + + +EE L E+R ++Q ER R E+ + +
Sbjct: 1034 LREEREKRRLQ-ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 199 LLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPP 258
LLR + E R Q EE+ +LQ +QL L EE RR
Sbjct: 1093 LLREEPEKRRRQERERQCREEE--------ELQQEEEQL------LREEREKRRRQELER 1138
Query: 259 PGAEEKEKEKEKE----KEPD---NVDLVSELRAE---NQRLTASLRELQEGLQQEASRP 308
EE+E ++E+E +EP+ +L + R E Q LRE QE +QE R
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 309 GAPGSERILLDILEHDWREAQDSRQEL-----CQKLHAVQGELQWAEELRDQYLQEMEDL 363
E + + +R+ +D R +L +K +AV+ + + ++ +++ED
Sbjct: 1199 YRE-EEELQRQKRKQRYRD-EDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 364 RLKHRTLQKDCDLYKHRMATVLAQLEEIEKERD-QAIQSRDRIQLQYSQSLIEKDQYRKQ 422
+L+ R Q+D + +L + +E ++E++ + Q RDR + L ++Q +
Sbjct: 1257 QLRDRQSQQD-------LQHLLGEQQERDREQERRRWQQRDR-HFPEEEQLEREEQKEAK 1308
Query: 423 VRGLEAERDELL 434
R +++ ++ L
Sbjct: 1309 RRDRKSQEEKQL 1320
Score = 50.8 bits (120), Expect = 6e-06
Identities = 80/340 (23%), Positives = 141/340 (41%), Gaps = 33/340 (9%)
Query: 114 QEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQ 173
+E Q +L EE + Q L R+ RE + Q + EQ L+ +ER +
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELE---RQYREEEELQQEEEQLLREEQEKRRQERER-QY 1199
Query: 174 RLRDQQQAQERCQRLRED-------WEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLR 226
R ++ Q Q+R QR R++ W+ + ++D R + + + LR
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 227 SRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVD-------- 278
R Q + L + + E R + EE++ E+E++KE D
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 279 LVSELRAENQRLTASLREL--QEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELC 336
L+ E R E +R + R+ +E L QE ER + +RE + QE
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER------DRKFREEELRHQEQG 1373
Query: 337 QKLHAVQGELQWAEELRDQYLQEMEDLRLKHR--TLQKDCDLYKHRMATVLAQLEEIEKE 394
+K + L+ E R ++L+E + LR + R L++D D L++ E K
Sbjct: 1374 RKFLEEEQRLRRQERER-KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 395 RDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELL 434
R++ Q R + + + +E++Q +Q R + +E L
Sbjct: 1433 REEEQQVR---RQERERKFLEEEQQLRQERHRKFREEEQL 1469
Score = 42.0 bits (97), Expect = 0.003
Identities = 72/348 (20%), Positives = 146/348 (41%), Gaps = 45/348 (12%)
Query: 124 LDEEGPEGLTQFLMTEVRRLREA------RKSQLQREQQLQARGR--VLEEERAGLEQRL 175
LD G +FL+ + ++ +A + + L E++ + G+ +L++ R +QR
Sbjct: 63 LDSNGRVDFNEFLLF-IFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRR 121
Query: 176 ---RDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQL 232
RD+Q +E QR R+ + EL ++++ EK L RD Q
Sbjct: 122 FEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS------------EKQER-LEQRDRQ- 167
Query: 233 AVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTA 292
R +EE L R R EE+ E+E+ + + E E Q
Sbjct: 168 ----------RRDEE---LWRQRQEWQEREERRAEEEQLQSCKGHE-TEEFPDEEQLRRR 213
Query: 293 SLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEEL 352
L EL+ ++E + +R+ + E +WR+ + ++ +KL + + Q +
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 353 RDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEK-----ERDQAIQSRDRIQL 407
++ L+++E L+ +++ + R L + +E E+ ER + + R++ +
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 408 QYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
+ Q L + + R++ + + +E E + E QL+R Q
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Score = 37.4 bits (85), Expect = 0.074
Identities = 46/171 (26%), Positives = 79/171 (46%), Gaps = 23/171 (13%)
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLK 203
+E + QL+R+++ + ++LEEE+ E R Q + QER ++ RE+ E LR +
Sbjct: 1733 QETEQEQLRRQERYR---KILEEEQLRPE-REEQQLRRQERDRKFREE------EQLRQE 1782
Query: 204 DENYMIAMRLA--------QLSEEKNSAVLR--SRDLQLAVDQLKLKVSRLEEECALLRR 253
E + + + QL +E+ LR RD + ++ +L+ LEE+ LR+
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ---LEEQEQRLRQ 1839
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQE 304
R AEE+ +EK + + E + Q LRE QQ+
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK 1890
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.5 bits (171), Expect = 8e-12
Identities = 84/342 (24%), Positives = 148/342 (43%), Gaps = 30/342 (8%)
Query: 131 GLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLRE 190
G T L EV L + R+ + ++L+ + VLE+E L + + Q + Q +E
Sbjct: 449 GQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508
Query: 191 DWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECAL 250
+ + +R ++ + M L E S ++ R+ L L+ ++ R E+
Sbjct: 509 EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA-LESSHLEGELLRQEQTEVT 567
Query: 251 LRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTA--------------SLRE 296
AR AE E + E V++LRA +L+A L +
Sbjct: 568 AALARAEQSIAELSSSENTLKTE------VADLRAAAVKLSALNEALALDKVGLNQQLLQ 621
Query: 297 LQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQY 356
L+E Q SR A R L + D EA+ R+ L +K ++ +LQ AEE +
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQV---DLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 357 LQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKE--RDQAIQSRDRIQLQYSQSLI 414
++ D++ + +QK +H+ QLE++ +E R + + +R +Q ++L+
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR---AVQEKEALV 735
Query: 415 -EKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
EK +++ +E +R +L L L K LLE L AQ
Sbjct: 736 REKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
Score = 59.7 bits (143), Expect = 1e-08
Identities = 92/375 (24%), Positives = 163/375 (43%), Gaps = 48/375 (12%)
Query: 125 DEEGPEGLTQFLMT---EVRRLREA-RKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ 180
++EG L Q EV +LRE K + +Q+L LE E+ LE RL++QQ
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896
Query: 181 AQERCQRLREDWEA---GSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQL 237
E Q RE+ +L ++L+ E +++ L +K A S+ L+ +
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD-ASQQLERLRQDM 955
Query: 238 KLKVSRLEEECALLRRARGPPPGAEEKEKEKE-KEKEPDNVDLVSELRAENQRLTASLRE 296
K++ + +E +L+ + +E ++E KE + D ++ L+ E+ L +
Sbjct: 956 KVQKLKEQETTGILQ--------TQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 297 LQEGLQQEASRPGA-PGSERILLDILEHDWREAQD--------SRQELCQKLHAVQGE-- 345
LQ+ ++ S+ A S+R++ ++ RE Q+ R++ L ++ E
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQR 1067
Query: 346 ---LQWAEELRDQYL----QEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQA 398
LQ A+ +R Q L Q+M++ + + + L +L + E EKE D
Sbjct: 1068 LLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQ---------EVKEKEADFL 1118
Query: 399 IQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGT 458
Q ++ + S I + Q R + EA+ +L L S T++ LE Q G
Sbjct: 1119 AQEAQLLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRS---TESQLEALAAEQQPGN 1174
Query: 459 CLKACASSHSLCSNL 473
+A A SL S L
Sbjct: 1175 QAQAQAQLASLYSAL 1189
Score = 56.2 bits (134), Expect = 2e-07
Identities = 92/383 (24%), Positives = 158/383 (41%), Gaps = 75/383 (19%)
Query: 137 MTEVRRLREARKSQLQ-------REQQLQARG----RVLEEERAGLEQRL----RDQQQA 181
++E R +EA +QL+ R++++ AR L E+A LE RL RD+Q
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 182 QERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKV 241
E+ Q L E L + +N +I + QL + + +Q V LKL++
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 242 ------SRLEEECALLRRARGPPPG---------AEEKEKEKEKEK--------EPDNVD 278
+ E + A + A+ G A EKE + +EK + +
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 279 LVSELRAENQRLTASLRELQEGL-----QQEASRPGAPGS----------ERI-LLDILE 322
+ L E L L+E Q + Q+E R A + ER+ LL+ L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 323 HDWREAQDSRQEL--------CQKLH------AVQGELQWAE-ELRDQYLQEMEDLRLKH 367
+E D+ Q+L QKL +Q +LQ A+ EL++ Q +DL
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL---- 991
Query: 368 RTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLE 427
LQ++ + Q+E+++ + S+ ++ + + L E +Y + + LE
Sbjct: 992 AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELE 1051
Query: 428 AERDELLTTLTSLEGTKALLEVQ 450
E+ L TL+ +E + LL +Q
Sbjct: 1052 REKASL--TLSLMEKEQRLLVLQ 1072
Score = 55.5 bits (132), Expect = 3e-07
Identities = 95/445 (21%), Positives = 181/445 (40%), Gaps = 79/445 (17%)
Query: 80 RLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTE 139
++ ++ +CR + LE L E LT Q R + D E + + + E
Sbjct: 1478 QIQELEKCR------SVLEHLPMAVQEREQKLTVQREQIR-ELEKDRETQRNVLEHQLLE 1530
Query: 140 VRRLREARKSQLQREQQLQARGRVLE---------EERAGLEQRLRDQQQAQERCQRLR- 189
+ + + +SQ + Q L+ + LE + +Q+L + + Q QR+
Sbjct: 1531 LEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL 1590
Query: 190 -----------EDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLK 238
++ +A S ++ L+ + ++A L + +E S + +LQ + L
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650
Query: 239 LKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQ 298
+ R ++E L + E++ + K E D + LR + LT + +Q
Sbjct: 1651 QDLERRDQELMLQKERIQV---LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707
Query: 299 EGLQQ-----EASRPGAPGSERILLDILE---------HDWREAQDSRQELCQKLHAVQG 344
E ++ +A R + IL D + H+ +E +D ++ Q LH G
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 345 ELQWAEELRDQYL----QEMEDLR----LKHRTLQKDCDLYKHRMATVLAQLEEIEKERD 396
E R+Q + Q++++ R LK ++LQ D + +A +LE +++E+
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 397 QAIQSRDRIQ---------LQYSQSLI-----EKDQYRKQVRGLEAE----------RDE 432
QA +R++ L+ + + E +++Q R LE E +E
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Query: 433 LLTTL--TSLEGTKALLEVQLQRAQ 455
+L L S E KALL +Q Q A+
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAE 1912
Score = 53.9 bits (128), Expect = 8e-07
Identities = 116/526 (22%), Positives = 206/526 (39%), Gaps = 91/526 (17%)
Query: 6 EAGEAEEEAGAG-----SGSEAEEDALWERIEGVR----HRLARALNPAKLTPYLRQCRV 56
+ +AE+E + E E + L E+ E R LA+AL + + R+
Sbjct: 832 QLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRL 891
Query: 57 IDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEP 116
++Q E E + R R L ++ ++ + LE L E E
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQ-MQLETEKERVSLLETLLQTQKELADASQQLER 950
Query: 117 AQRCSMI--LDEEGPEGLTQFLMTEVRR-LREARKSQLQREQQLQARGRVLEEERAGLEQ 173
++ + L E+ G+ Q + E +R L+EA + LQ L +++ L++
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQK 1010
Query: 174 RLRD---------------QQQAQERCQRLRE--------DWEAGSLELLRLKDENYMIA 210
++ D +Q+ QE+ + +E + E SL L ++ E ++
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 211 MRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEK 270
++ A ++ + LR +D+Q A + K L + LLR ++ KEKE
Sbjct: 1071 LQEADSIRQQELSALR-QDMQEAQGEQK----ELSAQMELLR----------QEVKEKEA 1115
Query: 271 EKEPDNVDLVSELRAEN---QRLTASL-------RELQEGLQQEASRPGAPGSER----- 315
+ L+ EL A + Q+L ASL +LQ L+ S+ A +E+
Sbjct: 1116 DFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQ 1175
Query: 316 --------ILLDILEHDWREAQDSRQEL------CQKLHAVQGELQWAEEL--RDQYLQE 359
L L+ +SR EL + ++ + A L R L
Sbjct: 1176 AQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTA 1235
Query: 360 MED------LRLKHRTL---QKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYS 410
+ L H+ L Q+ D+ + ++ + +L + E E+ Q +Q Q S
Sbjct: 1236 LSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS 1295
Query: 411 QSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQG 456
Q+ EK ++ + LE+E EL T+ SL+ E+Q AQG
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQG 1341
Score = 53.9 bits (128), Expect = 8e-07
Identities = 84/349 (24%), Positives = 145/349 (41%), Gaps = 62/349 (17%)
Query: 113 GQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLE 172
G EP Q + L + GP LT V L + QQ + VL ++ LE
Sbjct: 1215 GLEPDQNGARSLFKRGPL-LTALSAEAVASALHKLHQDLWKTQQTRD---VLRDQVQKLE 1270
Query: 173 QRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQL 232
+RL D + + + +D + +L+Q EEK+ + L+
Sbjct: 1271 ERLTDTEAEKSQVHTELQD-----------------LQRQLSQNQEEKSKWEGKQNSLES 1313
Query: 233 AVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTA 292
+ +L ++ L+ LRRA E + E + E+E L+A + LTA
Sbjct: 1314 ELMELHETMASLQSR---LRRA-------ELQRMEAQGEREL--------LQAAKENLTA 1355
Query: 293 SLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEEL 352
+ LQ + + ++ A G ILE D R A R L K V+ E +
Sbjct: 1356 QVEHLQAAVVEARAQASAAG-------ILEEDLRTA---RSALKLKNEEVESERE----- 1400
Query: 353 RDQYLQEMEDLRLKH-RTLQKDCDLYKHRMA-------TVLAQLEEIEKERDQAIQSRDR 404
R Q LQE +L++ + LQ++ L +A T+ Q++E+EK+R+ + +
Sbjct: 1401 RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALEL 1460
Query: 405 IQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQR 453
+ L + E D ++Q++ LE R L +++ + L VQ ++
Sbjct: 1461 LSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Score = 52.4 bits (124), Expect = 2e-06
Identities = 86/396 (21%), Positives = 164/396 (41%), Gaps = 61/396 (15%)
Query: 114 QEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQ 173
+E ++ + L E G E TQ + + R S+ QR L+ +L ++ +E
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS-LEHMKLILRDKEKEVEC 1740
Query: 174 RLRDQQQAQERCQRLREDWEA-----GSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSR 228
+ + QE +L + + G LL + E ++ ++ QL E + L+ +
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ-QQLQEAREQGELKEQ 1799
Query: 229 DLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKE--------------KEKEP 274
LQ +D+ + +++ ++E L++ + G EE+ KEK KE+
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859
Query: 275 DNVD-------LVSELRAENQR----------LTASLRELQE---GLQQEASRPGAPGSE 314
+ D L EL E +R L A RE ++ LQQ+ +
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ--EH 1917
Query: 315 RILLDILEHDWREAQDSRQELCQKLHAVQGELQ-----------WAEELRDQYLQEMEDL 363
+ L+ W +AQ +E Q+L A++ E Q AE L++ + L
Sbjct: 1918 EVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAAL 1977
Query: 364 RLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQV 423
+ K + L + +L + A+ ++ + + Q + +++Q + + +Y++ V
Sbjct: 1978 QGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDV 2037
Query: 424 RGLE---AERDELLTTLTSLEGTKALLEVQL-QRAQ 455
+ L+ A+RDE L + + LLE L QR Q
Sbjct: 2038 QQLQQALAQRDE---ELRHQQEREQLLEKSLAQRVQ 2070
Score = 51.6 bits (122), Expect = 4e-06
Identities = 77/335 (22%), Positives = 139/335 (41%), Gaps = 44/335 (13%)
Query: 178 QQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQL 237
+++A ER Q L + G LE L+D ++ L Q ++ + L+ V+ L
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 238 KLKVSRL-EEECALLRRARGPPPGAEE--KEKEKEKEKEPDNVDLVSELRAENQRLTASL 294
+ + L E E +L R A+ ++ K+ + +E DN+ A+ SL
Sbjct: 317 ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI-------AQGSGHENSL 369
Query: 295 RELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAV----QGELQWAE 350
EL + + A + ++ +L + QD RQ+L AV Q QW E
Sbjct: 370 -ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE 428
Query: 351 E-------------LRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKER-- 395
E RD + DL+ + +L K+ +L + + QLE +E+E
Sbjct: 429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWR 488
Query: 396 ------------DQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGT 443
D A ++ Q + ++ E+++ ++ + GLEA++ E L+ L +L
Sbjct: 489 LRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA 548
Query: 444 --KALLEVQLQRAQGGTCLKACASSHSLCSNLSST 476
+ LE +L R + A A + + LSS+
Sbjct: 549 LESSHLEGELLRQEQTEVTAALARAEQSIAELSSS 583
Score = 50.8 bits (120), Expect = 6e-06
Identities = 77/321 (23%), Positives = 140/321 (43%), Gaps = 30/321 (9%)
Query: 139 EVRRLREARKSQLQREQQLQ-ARGRVLEEERAGLEQRLRDQQQAQE----RCQRLRE--D 191
EV RE R LQ + +L+ A+G+ L+E A L Q L ++++ E + Q L + +
Sbjct: 1394 EVESERE-RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE 1452
Query: 192 WEAGSLELLRL--KDENYMIAMRLAQLSE-EKNSAVLRSRDLQLAVDQLKLKVSRLEEEC 248
+ +LELL L K N + ++ Q+ E EK +VL L +AV + + K++ E+
Sbjct: 1453 MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH--LPMAVQEREQKLTVQREQI 1510
Query: 249 ALLRRARGPPPGAEEK---EKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG----- 300
L + R E E EK+ + V +L+ + L EL+E
Sbjct: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
Query: 301 LQQEASRP--GAPGSERILLDILEHDWREAQDSRQELCQKLHAVQG-------ELQWAEE 351
QQ+ + G ++R+ L L D E Q ++H ++ ELQ ++
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 352 LRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQ 411
+++E+L+ + L +D + + +++ +E +R + + + Q
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 412 SLIEKDQYRKQVRGLEAERDE 432
SL E+ + R L ER E
Sbjct: 1691 SLRERGRELTTQRQLMQERAE 1711
Score = 47.8 bits (112), Expect = 5e-05
Identities = 67/307 (21%), Positives = 132/307 (42%), Gaps = 36/307 (11%)
Query: 134 QFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWE 193
Q L ++ + +E + ++ L++ L E A L+ RLR + + Q RE +
Sbjct: 1288 QDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347
Query: 194 AGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRR 253
A E L + E+ A+ + + ++A + DL+ A LKLK +E E R
Sbjct: 1348 AAK-ENLTAQVEHLQAAV--VEARAQASAAGILEEDLRTARSALKLKNEEVESE-----R 1399
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGS 313
R + + K + + +N+ L+++ AE + +LR + L+++
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM------ 1453
Query: 314 ERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKD 373
++ L++L D ++ QE+ +L+ + +QE+E R L
Sbjct: 1454 QKAALELLSLDLKKRN---QEV---------------DLQQEQIQELEKCRSVLEHLPMA 1495
Query: 374 CDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDEL 433
+ ++ Q+ E+EK+R+ R+ ++ Q + L +KDQ + RG + +
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRE---TQRNVLEHQLLE-LEKKDQMIESQRGQVQDLKKQ 1551
Query: 434 LTTLTSL 440
L TL L
Sbjct: 1552 LVTLECL 1558
Score = 41.2 bits (95), Expect = 0.005
Identities = 73/353 (20%), Positives = 147/353 (41%), Gaps = 17/353 (4%)
Query: 107 HFTLLTGQEPAQRCSMILDEEGP--EGLTQFLMTEVRRLREARKSQLQREQQLQARGRVL 164
H L +E A+R L EG + L + L RE K+ L +QQ + +
Sbjct: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEH 1917
Query: 165 EEERAGLEQR-LRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEE--KN 221
E E L+ L+ Q +ER Q L EA E + + R L E K
Sbjct: 1918 EVETRALQDSWLQAQAVLKERDQEL----EALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 222 SAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVS 281
A L+ ++ L ++Q +L S LE A L+ + + +E + +E + D
Sbjct: 1974 HAALQGKEQHL-LEQAELSRS-LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 282 ELRAENQRLTASLRELQEGLQQEASRPGAPG---SERILLDILEHDWREAQDSRQELCQK 338
+ + Q+L +L + E L+ + R ++R+ ++++ Q+ +E +
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 339 LHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQA 398
LH ELQ ++Q E+ +LR + + + H+ + + Q +++ +
Sbjct: 2092 LHQSVRELQLTLAQKEQ---EILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRL 2148
Query: 399 IQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQL 451
+ +R+Q Q+ + ++R++ + L + +++SL+ L+ +
Sbjct: 2149 QRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASV 2201
Score = 40.8 bits (94), Expect = 0.007
Identities = 73/325 (22%), Positives = 130/325 (40%), Gaps = 19/325 (5%)
Query: 139 EVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLE 198
E+ LR +S +E+ +AR L+E L+ ++Q L EA +
Sbjct: 1941 ELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTAT 2000
Query: 199 LLRLKDENYMIAMRLAQLSEEKNSAVLRSRDL--QLAVDQLKLKVSRLEEECALLRRARG 256
L D + +L + + + + +DL Q V QL+ +++ +EE LR +
Sbjct: 2001 LQASLDACQAHSRQLEEALRIQEGEI-QDQDLRYQEDVQQLQQALAQRDEE---LRHQQE 2056
Query: 257 PPPGAEEKEKEKEKEKEPDNVDLVSELRAENQ--RLTASLRELQEGLQQEASR--PGAPG 312
E+ ++ +E + + R E + L S+RELQ L Q+
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116
Query: 313 SERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQK 372
+R L+ L H + + Q L KL +++ LQ E L++ E ++ R +
Sbjct: 2117 QQRNNLEALPHSHKTSPMEEQSL--KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQ 2174
Query: 373 DCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAER-D 431
D L + ++ L+E+ ++ RD Q + +D+ R LE ER
Sbjct: 2175 DLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL------QDELELTRRALEKERLH 2228
Query: 432 ELLTTLTSLEGTKALLEVQLQRAQG 456
T T+ G++ VQL G
Sbjct: 2229 SPGATSTAELGSRGEQGVQLGEVSG 2253
Score = 36.2 bits (82), Expect = 0.16
Identities = 69/311 (22%), Positives = 119/311 (38%), Gaps = 66/311 (21%)
Query: 114 QEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERA-GLE 172
QE Q+ L + E Q ++ A++ Q Q+ Q G+ EEE GL
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
Query: 173 QRLRDQQ----QAQERCQRLREDWEAGSLELL---------------------RLKDENY 207
Q +R+ Q Q ++ LRE + +LE L RL+ E
Sbjct: 2094 QSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELE 2153
Query: 208 MIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKE 267
+ L Q + +++DL L++ Q K VS L+E L+ A E++
Sbjct: 2154 RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQ--------ASVLERD 2205
Query: 268 KEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWRE 327
E+++ D ++L E +RL + PGA + +
Sbjct: 2206 SEQQRLQDELELTRRA-LEKERLHS---------------PGATSTAEL----------- 2238
Query: 328 AQDSRQELCQKLHAVQG-ELQWAEE--LRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATV 384
SR E +L V G E + + + + + Q +E L+ L+ D + +
Sbjct: 2239 --GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQL 2296
Query: 385 LAQLEEIEKER 395
+ LE++E+ER
Sbjct: 2297 RSTLEQVERER 2307
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 68.9 bits (167), Expect = 2e-11
Identities = 120/493 (24%), Positives = 201/493 (40%), Gaps = 69/493 (13%)
Query: 22 AEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEE------EVLSTYRFPCRV 75
AE++AL E + +R R A AL Q R ++ Q+ E E+ R
Sbjct: 725 AEQEALREEVAQLR-RKAEALGDELEA----QARKLEAQNTEAARLSKELAQARRAEAEA 779
Query: 76 NRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQF 135
+R + R + EA + LE E L+ A R + EG Q
Sbjct: 780 HREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAG 195
E R++ Q ++ + R E +A LE+ + ++ R + L+ + E
Sbjct: 840 EAAE-ERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQA 898
Query: 196 SLE---LLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLR 252
+LE LR K+ + L Q E + A S++ L +LK + +LEEE LR
Sbjct: 899 ALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALM--ELKTRALQLEEELFQLR 956
Query: 253 RAR---GPPPGAEEKEKEKEK----EKEPDNVDLVSE---LRAENQRLTASLRELQ---- 298
+ GP AE + E + E E N LV+E L+ + Q L L LQ
Sbjct: 957 QGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQ 1016
Query: 299 ------EGLQQEASRPGAPGSERIL--------LDILEHDWREAQDSRQELCQKLHAVQG 344
+ Q+ +SR A S + L++LE + R A+ S++E + A+
Sbjct: 1017 ELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLR 1076
Query: 345 ELQWAEELRDQYLQEMEDL--------------RLKHRTLQKDCDLYKHRMATVLAQLEE 390
+ + +L+ + E+E L L HR LQ + + + A+V AQ
Sbjct: 1077 DHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVA 1136
Query: 391 IEKERDQAIQSRD----------RIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL 440
+ ER++ +Q R+Q ++ ++ + + ++ L+ ER EL L L
Sbjct: 1137 LLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARL 1196
Query: 441 EGTKALLEVQLQR 453
E +A LE+Q Q+
Sbjct: 1197 ELERAQLEMQSQQ 1209
Score = 49.3 bits (116), Expect = 2e-05
Identities = 63/221 (28%), Positives = 95/221 (42%), Gaps = 44/221 (19%)
Query: 136 LMTEVRRLREARKSQLQREQQLQA---------------RGRVLEE--ERAGLEQRLRDQ 178
L +R L A + R +QLQA R R++++ + GLE+ LR
Sbjct: 1102 LKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRL 1161
Query: 179 QQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLK 238
Q +R Q L + S E L+ E + RLA+L E+ ++S+ L+ + QL
Sbjct: 1162 QSEHDRAQMLLAEL---SRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLD 1218
Query: 239 LKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQ 298
L RL +C LL + R A+E+E +L AE Q L+ REL
Sbjct: 1219 LSACRLTTQCELLTQLR----SAQEEENR--------------QLLAEVQALSRENRELL 1260
Query: 299 EGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKL 339
E + SR +R LD L RE +Q+L +K+
Sbjct: 1261 E--RSLESRDHLHREQREYLDQLNALRRE----KQKLVEKI 1295
Score = 35.0 bits (79), Expect = 0.37
Identities = 55/240 (22%), Positives = 92/240 (38%), Gaps = 64/240 (26%)
Query: 139 EVRRLR--------------------EARKSQLQREQQLQA----RGRVLEEERAGLEQR 174
++RRLR EA +L++E Q + R + EE L +R
Sbjct: 266 QLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRER 325
Query: 175 LRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAM-----------------RLAQLS 217
+ QE +R RE +A +L++E + + R A+L
Sbjct: 326 AGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLH 385
Query: 218 E-EKNSAVLRSR--DLQLAVDQLKLKVSRLEEECA----LLRRARGPPPGAEEK------ 264
E ++ + +LR+R + +D L+ +V +L EE L+R+ PPPG+ +
Sbjct: 386 ETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGA 445
Query: 265 EKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHD 324
+ E + L EN+ L L+ LQ G PG + LL+ D
Sbjct: 446 APSLQDEVREAEAGRLRTLERENRELRGLLQVLQ----------GQPGGQHPLLEAPRED 495
Score = 31.6 bits (70), Expect = 4.0
Identities = 49/185 (26%), Positives = 83/185 (44%), Gaps = 29/185 (15%)
Query: 288 QRLTASLRELQE-GLQQEA-SRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAV--- 342
QRL L E + L+ EA SR A G L L + + + RQEL +K +
Sbjct: 225 QRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDS 284
Query: 343 QGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSR 402
Q E+Q E + QE + L + K +LY+ + + + + +++ + R
Sbjct: 285 QAEVQGLEAEIRRLRQEAQALSGQ----AKRAELYREEAEALRERAGRLPRLQEELRRCR 340
Query: 403 DRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKA 462
+R+Q + Y+ Q+ E + +L+ + LE +KALLE QL+ A+ +
Sbjct: 341 ERLQAA--------EAYKSQL-----EEERVLSGV--LEASKALLEEQLEAAR-----ER 380
Query: 463 CASSH 467
CA H
Sbjct: 381 CARLH 385
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 67.0 bits (162), Expect = 9e-11
Identities = 65/299 (21%), Positives = 137/299 (45%), Gaps = 17/299 (5%)
Query: 156 QLQARGRVLEEERAGLEQRLR----DQQQAQERCQRLREDWEAGSLELLRLKDENYMIAM 211
Q++A+ + +E E+ LE ++ + + E +L+E LE+ LK ++ +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 212 RLAQLSEEKNSAVLRS------RDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKE 265
L ++ S+ L+ R+LQ +D+L+ +S+ EE+ + L A K
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 266 KEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDW 325
+ + E+E L ++L + + +++LQ L + +P G E ++
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 326 REAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVL 385
+ A SR+E ++ ++Q EL A ++ + + D+ + K+ D TVL
Sbjct: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKD-------TVL 1538
Query: 386 AQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTK 444
+L +++ERD+ I DR L+ + + + GL ++++L+ + SL+ +K
Sbjct: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
Score = 51.6 bits (122), Expect = 4e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 62/318 (19%)
Query: 130 EGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLR 189
E L Q + + + ++ + QLQ+ ++ LE + A LE++L++ ++A E LR
Sbjct: 2538 EDLNQVITIKDSQQKQLLEVQLQQNKE-------LENKYAKLEEKLKESEEANE---DLR 2587
Query: 190 EDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECA 249
+ A L EEK L++++ QL +V+ L+EE
Sbjct: 2588 RSFNA---------------------LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Query: 250 LLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPG 309
L A+ K KE+E V +S L + +Q+ A L E +Q+EA++
Sbjct: 2627 L------GLYHAQLKVKEEE-------VHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
Query: 310 APGSERILLDI--LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKH 367
+++ ++ L HD ++ E + AEE + +++ ++ K
Sbjct: 2674 GEIEDKLKKELKHLHHD--------------AGIMRNETETAEERVAELARDLVEMEQKL 2719
Query: 368 RTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLE 427
+ K+ ++ + + ++ RD A + D ++ +Y SL E Q ++Q L
Sbjct: 2720 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL-LN 2778
Query: 428 AERDELLT-TLTSLEGTK 444
ERD LL+ T S+ T+
Sbjct: 2779 RERDALLSETAFSMNSTE 2796
Score = 48.5 bits (114), Expect = 3e-05
Identities = 86/430 (20%), Positives = 170/430 (39%), Gaps = 82/430 (19%)
Query: 121 SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRL----- 175
S I ++G + Q +T++ L + + +L R +L+ EEE+ LE+RL
Sbjct: 1875 SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK---ETAEEEKDDLEERLMNQLA 1931
Query: 176 ----------RDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVL 225
+D AQ + + L + + + L++E + ++ E L
Sbjct: 1932 ELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Query: 226 --------------RSRDLQLAVDQLKLKVSRLEEEC--------ALLRRARGPPPGAEE 263
+++LQ + + + +V +L+++C AL R + E
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 264 KEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGA----------PGS 313
+K+ E KE N+ E R + Q AS + L + Q EA+R A
Sbjct: 2052 SQKDLEITKE--NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNK 2109
Query: 314 ERILLDI------LEHDWREAQD----SRQELCQKLHAVQGELQWAEELRDQYLQEMEDL 363
E + + LE +A++ ++ + +KL A++ E EE + +
Sbjct: 2110 ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169
Query: 364 RLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQ----- 418
+ + LQ++ D ++A + ++ +RD+ I + + ++S ++ K++
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK 2229
Query: 419 ------YRKQVRGLEAERDELLTTLTSLE------GTKALLEVQLQRAQGGTCLKACASS 466
+ Q+R + +EL ++ LE +KA EVQLQ+ C +
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK---VCDTLQGEN 2286
Query: 467 HSLCSNLSST 476
L S L T
Sbjct: 2287 KELLSQLEET 2296
Score = 46.6 bits (109), Expect = 1e-04
Identities = 77/445 (17%), Positives = 166/445 (37%), Gaps = 140/445 (31%)
Query: 141 RRLREARKSQLQREQQLQARGRVLEEERAGLEQRL-----------RDQQQAQER----- 184
RRL +A + L+ ++ +Q + L E+ LE+ + ++ QQ QE
Sbjct: 2125 RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTV 2184
Query: 185 ---------CQRLRED----------WEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVL 225
L++D WE + ++ K+E + +E N +VL
Sbjct: 2185 TQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL--------KEDNCSVL 2236
Query: 226 RS--RDLQLAVDQLKLKVSRLEEE------------------CALLRRARGPPPGAEEKE 265
+ R + + +++LK+ +SRLE + C L+ E+
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 266 KEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDW 325
+ + + L SEL++ +LT L++ +Q+ + G + + + +
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 326 REAQDSRQ---ELCQKLH-------------------AVQGELQWAEELRDQYLQEMEDL 363
+ + Q EL +LH A+Q + + D+ ++E+E+L
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENL 2416
Query: 364 RLKH-------------------------RTLQKDCDLYKHRMATVLAQLEEIEKERDQA 398
+ +T++K+ K ++ + + + ++ +RD+
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Query: 399 IQSRDRIQLQYSQSLIEKDQ-----------YRKQVRGLEAERDELLTTLTSLEG----- 442
+ +++ ++ ++EKDQ ++++RGL + D+L + L+
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
Query: 443 --------------TKALLEVQLQR 453
K LLEVQLQ+
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQ 2561
Score = 46.2 bits (108), Expect = 2e-04
Identities = 43/206 (20%), Positives = 90/206 (43%), Gaps = 43/206 (20%)
Query: 234 VDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTAS 293
+DQLK +++ LEEE ++K KE + E + L+S++ ++ L
Sbjct: 1842 IDQLKERIAGLEEE--------------KQKNKEFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 294 LRE------LQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQ 347
E L + +Q+E SR + + E E D + L +L + G +
Sbjct: 1888 QEEVTKMNLLNQQIQEELSR---------VTKLKETAEEEKDDLEERLMNQLAELNGSI- 1937
Query: 348 WAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQL 407
Y Q++ D ++K+ L+ + M + + E+E+E+ Q ++ + +++
Sbjct: 1938 ------GNYCQDVTDAQIKNELLESE-------MKNLKKCVSELEEEKQQLVKEKTKVES 1984
Query: 408 QYSQSLIEKDQYRKQVRGLEAERDEL 433
+ + +EK Q ++ G ++ EL
Sbjct: 1985 EIRKEYLEKIQGAQKEPGNKSHAKEL 2010
Score = 45.8 bits (107), Expect = 2e-04
Identities = 63/325 (19%), Positives = 135/325 (41%), Gaps = 40/325 (12%)
Query: 152 QREQQLQARGRVLEEERAGLEQRLRDQQ-QAQERCQRLREDWEAGSLELLRLKDENYMIA 210
Q++ QLQ + L+EER + +++ + A+ + L + E +K + +
Sbjct: 70 QKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIE-------EMKAQGGTVL 122
Query: 211 MRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLR------RARGPPPGAEEK 264
Q E+ + S + ++ ++++K K+ EE + L+ +A P + E
Sbjct: 123 PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEM 182
Query: 265 E-----KEKEKEKEPDNVDLVSEL-------------RAENQRLTASLRELQEGLQQEAS 306
E K++ +EKE L ++L R ++ R +R ++ L Q +
Sbjct: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVT 242
Query: 307 RPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLK 366
+ + L +L+ E ++S Q + +Q EL AE+ Q+++ + +
Sbjct: 243 QADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAE 302
Query: 367 HRTLQKDCDLYKHRMATVLAQLEEIEKERDQAI----QSRDRIQLQYSQSLIEKDQYRKQ 422
H TL+ + + +L ++E ER + + + Q+ Q+ + + +
Sbjct: 303 HNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESR 362
Query: 423 VRGLE----AERDELLTTLTSLEGT 443
LE AE +E + + SL+ T
Sbjct: 363 YSALEQKHKAEMEEKTSHILSLQKT 387
Score = 45.1 bits (105), Expect = 4e-04
Identities = 80/399 (20%), Positives = 179/399 (44%), Gaps = 61/399 (15%)
Query: 142 RLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLR 201
++ E ++ Q+E ++ ++L E++ +E QQ +E+ Q++ E
Sbjct: 860 KVEELSQALSQKELEITKMDQLLLEKKRDVETL---QQTIEEKDQQVTEI---------- 906
Query: 202 LKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGA 261
++ + ++ QL+EEK S L +++ L+E+ LL RA
Sbjct: 907 ----SFSMTEKMVQLNEEKFS--------------LGVEIKTLKEQLNLLSRA------- 941
Query: 262 EEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDIL 321
E+ K+++ E DN ++ S L+ ++ + + +E LQ E +R
Sbjct: 942 ---EEAKKEQVEEDN-EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQR------ 991
Query: 322 EHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381
+ + A +R+EL Q++ ++ EL L+D+ +E+ + +++D + ++
Sbjct: 992 KRKLQAALINRKELLQRVSRLEEELA---NLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
Query: 382 ATVLAQLEEIEKERDQAIQSRDRIQLQY-SQSLIEKDQYRKQVRGLEAERDELLTTLTSL 440
V ++ +EIE Q I ++ ++LQ+ + L EK +Q + L + ++ L
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKE-VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ----- 1102
Query: 441 EGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGG 500
+ T + +Q + ++ ++ +S++ S+ S + E + + P TG ++
Sbjct: 1103 DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE--TVVISPPCTG-SSEHWK 1159
Query: 501 PEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREED 539
PE A + EKE + + S +IL++ +E++
Sbjct: 1160 PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKE 1198
Score = 43.1 bits (100), Expect = 0.001
Identities = 70/344 (20%), Positives = 137/344 (39%), Gaps = 32/344 (9%)
Query: 139 EVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRL----RED--W 192
E+ L+ + LQ + + + AGLE LR+ Q + Q+L ED +
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH-LRELQPKLDELQKLISKKEEDVSY 1410
Query: 193 EAGSLE-----LLRLKDE----NYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSR 243
+G L L +++ E +I QL + R + LQ+ + ++K K
Sbjct: 1411 LSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470
Query: 244 LEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQ 303
+ EE ++ + A KE KE + +L S R +RLT SL +++ +
Sbjct: 1471 IGEESRAKQQIQRKLQAALISRKEALKENKSLQEEL-SLARGTIERLTKSLADVESQVSA 1529
Query: 304 EASRPGAPGSERILL----DILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQE 359
+ LL D L + + Q L +++ L+ E +++ ++E
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 360 MEDLRL-----------KHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQ 408
+E L+ KH+ LQK+ ++ V + E I+ + Q + + +
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649
Query: 409 YSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQ 452
+ K + KQ++ E E +E+ + +K ++L+
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
Score = 41.2 bits (95), Expect = 0.005
Identities = 74/356 (20%), Positives = 139/356 (39%), Gaps = 49/356 (13%)
Query: 142 RLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQA----QERCQRLR-EDWEAGS 196
+LR ++ + E+QLQ + +EE + + + + +QQ +E RLR E AG
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 197 L-----------------ELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKL 239
EL R+K E ++ + L EK+S +DL+ ++
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768
Query: 240 KVSRLE------EECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLT-- 291
K + LE + + PG E++ P + V ++ N ++
Sbjct: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD 1828
Query: 292 -ASLRELQEGLQQ-EASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWA 349
+S E+ LQQ + + G E E + ++ + L ++ GEL+
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFS-QTLENEKNTLLSQISTKDGELKML 1887
Query: 350 EE-------LRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSR 402
+E L Q +E+ + T +++ D + R+ LA+L +
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAEL-----NGSIGNYCQ 1942
Query: 403 DRIQLQYSQSLIEKD--QYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQG 456
D Q L+E + +K V LE E+ +L+ T +E + + L++ QG
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE--SEIRKEYLEKIQG 1996
Score = 40.8 bits (94), Expect = 0.007
Identities = 74/344 (21%), Positives = 135/344 (39%), Gaps = 57/344 (16%)
Query: 106 EHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLE 165
E LL+ E A++ + D E GL Q E+ + K +LQ E L + E
Sbjct: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY-DEMSPAGQISKEELQHEFDLLKKEN--E 989
Query: 166 EERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVL 225
+ + L+ L ++++ +R RL E EL LKDE+ + LSE + V
Sbjct: 990 QRKRKLQAALINRKELLQRVSRLEE-------ELANLKDES----KKEIPLSETERGEVE 1038
Query: 226 RSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRA 285
++ + + K S+ +E L++ EKE E + DL +L A
Sbjct: 1039 EDKENKEYSE--KCVTSKCQEIEIYLKQTIS----------EKEVELQHIRKDLEEKLAA 1086
Query: 286 ENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELC-QKLHAVQG 344
E Q A ++++ + LQ + ++ +D+L+ + E Q Q+L A G
Sbjct: 1087 EEQ-FQALVKQMNQTLQDKTNQ----------IDLLQAEISENQAIIQKLITSNTDASDG 1135
Query: 345 EL-------------------QWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVL 385
+ W EL ++ L ++ + LQ+ K +
Sbjct: 1136 DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQ 1195
Query: 386 AQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAE 429
+ + +E Q +R+Q Q+ + E + Q+R L+ +
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
Score = 35.4 bits (80), Expect = 0.28
Identities = 36/169 (21%), Positives = 73/169 (43%), Gaps = 8/169 (4%)
Query: 139 EVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLE 198
EV+ L++A S +L + L+++ + Q + + + + Q ++ +A +
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIM 2934
Query: 199 LLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQ----LAVDQLKLKVSRLEEECALLRRA 254
L+ EN L QL EK+S + R ++ +A+ ++S L+ LR +
Sbjct: 2935 QEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994
Query: 255 RG---PPPGAEEKEKEKEKEKEPD-NVDLVSELRAENQRLTASLRELQE 299
P +++ E PD + +LV E +L SL+E+ +
Sbjct: 2995 SSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ 3043
Score = 35.0 bits (79), Expect = 0.37
Identities = 63/263 (23%), Positives = 108/263 (41%), Gaps = 46/263 (17%)
Query: 106 EHFTLLTGQEPAQRCSMILDE----EGPEGLTQF--LMTEVRRLREARKSQLQREQQLQA 159
EH TL E + S IL E E E F L E+ L E + Q + +L++
Sbjct: 302 EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
Query: 160 RGRVLEEE-RAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSE 218
R LE++ +A +E++ Q+ Q L+ +A LKD+N + L +
Sbjct: 362 RYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA-------LKDQNSKL------LQD 408
Query: 219 EKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRAR---------------GPPPGAEE 263
+ AV ++ +Q DQL+ K + + L + G EE
Sbjct: 409 KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEE 468
Query: 264 -----KEKEKEKEKEPDNVDLVS----ELRAENQRLTASLRELQEGLQQEASRPGAPGSE 314
+++ E E E + L S EL+AEN++L++ + L+ Q SE
Sbjct: 469 NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLE--AQNRTGEADREVSE 526
Query: 315 RILLDILEHDWREAQDSRQELCQ 337
++DI A++S Q++ +
Sbjct: 527 ISIVDIANKRSSSAEESGQDVLE 549
Score = 34.7 bits (78), Expect = 0.48
Identities = 55/292 (18%), Positives = 128/292 (43%), Gaps = 50/292 (17%)
Query: 175 LRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAV 234
L+ Q +ER L E+ + L++E + L+Q+S + + LQ V
Sbjct: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL---LSQISTKDGELKM----LQEEV 1891
Query: 235 DQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDL----------VSELR 284
++ L +++EE + + + + AEE++ + E+ +L V++ +
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKET---AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 285 AENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQ- 343
+N+ L + ++ L++ + + E +++ + + R+E +K+ Q
Sbjct: 1949 IKNELLESEMKNLKKCVSE---------LEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 344 --GELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMA----TVLA-QLEEIEKERD 396
G A+EL++ ++ ++++ LQKDC Y+ +++ TV A + + E ++D
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVK----QLQKDCIRYQEKISALERTVKALEFVQTESQKD 2055
Query: 397 ---------QAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTS 439
QA++ R + Q + + + D + + + A+ +L L S
Sbjct: 2056 LEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107
Score = 32.3 bits (72), Expect = 2.4
Identities = 70/355 (19%), Positives = 142/355 (40%), Gaps = 45/355 (12%)
Query: 139 EVRRLREARKSQLQREQQLQA----RGRVLEEERAGLEQRLRDQQQAQERCQRL-REDWE 193
E++ +R+ + +L E+Q QA + L+++ ++ + + Q Q+L + +
Sbjct: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131
Query: 194 AGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRR 253
A + + L E +I+ SE + + LA+++ K ++ + +E R+
Sbjct: 1132 ASDGDSVALVKETVVISPPCTGSSEHWKPEL---EEKILALEKEKEQLQKKLQEALTSRK 1188
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNVDLVSEL----RAENQRLTASLRELQ----------- 298
A +E+ +E +++ D+ + + E EN+ + LR+LQ
Sbjct: 1189 AILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKL 1248
Query: 299 EGLQQEASRPGAPGSERILLDILE-HDWREAQDSRQELC-------QKLHAVQGELQWAE 350
Q+ S PG E L E H + +S LC + A+QG A+
Sbjct: 1249 PSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES--NLCPDWPSHSEDASALQGGTSVAQ 1306
Query: 351 ELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEE------IEKERDQAIQSRDR 404
E E + L+ + +L K + + QL+E +E E + +
Sbjct: 1307 IKAQLKEIEAEKVELELKVSSTTSELTK--KSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364
Query: 405 IQLQYSQSLIEKDQYR----KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
+ + Q +E Q + + +R L+ + DEL ++ E + L QL +
Sbjct: 1365 VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKE 1419
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 65.9 bits (159), Expect = 2e-10
Identities = 119/494 (24%), Positives = 195/494 (39%), Gaps = 59/494 (11%)
Query: 9 EAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDE--EEVL 66
E E+ A G +AE++A R E R R RV ++ E E+ L
Sbjct: 763 EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQL 822
Query: 67 STYRFP--------CRVNR--TGRLMDILRCR--GKRGYEAFLEAL---EFYYPEHFTLL 111
T R +++R +GR ++ + R +R EA A E EH L
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLA 882
Query: 112 TGQEPAQRCSMILDEEGP------EGLTQFLMTEVRRLR--EARKSQLQREQQLQARGR- 162
A+R L EE E L L R+L EAR+ QL+ E Q +
Sbjct: 883 VQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 163 -------------VLEEERAGLEQRLRDQQ--QAQERCQR-LREDWEAGSLELLRLKDEN 206
+ +E+A L++ L Q+ QA+ Q LRE A +L RL+ E
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 207 YMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEK 266
L + S + R ++ LA +L+ + L EE A L++ R E EK
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLA--RLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
Query: 267 EKEKE-KEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDW 325
++ KE + L +L L E++ + SR +R ++ L +
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQE---QDRSTVNALTSEL 1117
Query: 326 REAQDSRQELC----QKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381
R+ + R+E Q++ +Q + + + RD L+E E+LR + R L+ D + +
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRREL 1177
Query: 382 ATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEK-------DQYRKQVRGLEAERDELL 434
+L E ++ R+ Q ++ + E+ ++ R V+ E+ER L
Sbjct: 1178 LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLK 1237
Query: 435 TTLTSLEGTKALLE 448
E ALLE
Sbjct: 1238 LANEDKEQKLALLE 1251
Score = 62.8 bits (151), Expect = 2e-09
Identities = 120/479 (25%), Positives = 187/479 (39%), Gaps = 82/479 (17%)
Query: 12 EEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRF 71
E+ A S E+E+ AL E++ G RH LA ++ R + EQD V +
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLATI--SLEMERQKRDAQSRQEQDRSTVNAL--- 1113
Query: 72 PCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEG 131
T L D+ R +R A A E
Sbjct: 1114 ------TSELRDL---RAQREEAAAAHAQE------------------------------ 1134
Query: 132 LTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLRED 191
+ L + R L + R S L+ ++L+ + R+LE+ R GL + L + Q+ Q RE
Sbjct: 1135 -VRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193
Query: 192 WEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALL 251
+ EL R E L + +EE SAV ++ +++ LKL E++ ALL
Sbjct: 1194 QRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS---LKLANEDKEQKLALL 1250
Query: 252 RRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAP 311
AR KE + + V R E +R LR + L E +R G
Sbjct: 1251 EEAR--------TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRE 1302
Query: 312 GSERILLDILEHDWREAQDSRQE-LCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTL 370
+E L L R ++SR+E L + ++GE E +R ++L++ R L
Sbjct: 1303 LAE--LQGRLALGERAEKESRRETLGLRQRLLKGEAS-LEVMR-------QELQVAQRKL 1352
Query: 371 QKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAER 430
Q+ ++ R +L LEE + ++ QL +++ L ++ AE
Sbjct: 1353 QEQEGEFRTRERRLLGSLEE--------ARGTEKQQLDHARGL------ELKLEAARAEA 1398
Query: 431 DELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGP 489
EL L++ EG LE +L R + A A L S L L PSP P
Sbjct: 1399 AELGLRLSAAEGRAQGLEAELARVEVQR-RAAEAQLGGLRSALRRGLGLGRAPSPAPRP 1456
Score = 59.3 bits (142), Expect = 2e-08
Identities = 71/319 (22%), Positives = 143/319 (44%), Gaps = 35/319 (10%)
Query: 152 QREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAM 211
Q ++LQA L +R LE+ +Q+ A + R+R + E +L +L+ + ++A
Sbjct: 624 QEREKLQAAQEELRRQRDRLEE---EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
Query: 212 RLAQLSEEKNSAVLRSRDLQ-----LAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEK 266
L ++ E + A L+ LQ +A K + R+E E ++ + AEE
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR------AEEASL 734
Query: 267 EKEKEKEPDNVDLVSELRAENQRLTASLRELQ---EGLQQEASRPGAPGSERILLDILEH 323
+ K + +++ + + RL A L E + +G Q++A + E E
Sbjct: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE-------EQ 787
Query: 324 DWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMAT 383
+ E QE+ ++ ++G L+ AE+ ++ Q++ LR + LQ+ +++
Sbjct: 788 ERLEELRLEQEVARQ--GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Query: 384 VLAQLEEIEKERDQAIQSRDR-------IQLQYSQSLIEKDQYRKQVRGLEAERDELLTT 436
+LE+ +E + +++ +R + +++ ++ ++ R L E L
Sbjct: 846 REQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE 905
Query: 437 LTSLEGTKALLEVQLQRAQ 455
+LEG +L EVQ Q AQ
Sbjct: 906 KEALEG--SLFEVQRQLAQ 922
Score = 52.8 bits (125), Expect = 2e-06
Identities = 81/341 (23%), Positives = 145/341 (42%), Gaps = 42/341 (12%)
Query: 140 VRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLEL 199
+ R +A +S+L+ Q+ ++ + E + G ++RL++ A E LEL
Sbjct: 1605 LERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASES--------RTVKLEL 1656
Query: 200 LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPP 259
R E + RL E + L+ R VD L+ +V+ E + L+
Sbjct: 1657 QRRSLEGELQRSRLGLSDREAQAQALQDR-----VDSLQRQVADSEVKAGTLQLTVERLN 1711
Query: 260 GAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERIL-- 317
GA K +E E D V ++E A++ S R+ LQ+ + ++L
Sbjct: 1712 GALAKVEESEGALR-DKVRGLTEALAQSSASLNSTRDKNLHLQKALT--ACEHDRQVLQE 1768
Query: 318 -LDILEHDWREAQDSRQELCQKLHAVQGELQWAE-----------ELRDQYLQEMEDLRL 365
LD EA+ L +++ ++GE+ E +LR+ Q E
Sbjct: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1828
Query: 366 KHRTLQKDCD---LYKHRMATVLAQLEEIEKERDQAIQS-----RDRIQLQYSQSLIEKD 417
T+QK D L + R+ ++ L ++E E+ + +S +DR+ L+ + +E++
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE 1888
Query: 418 QYRKQ---VRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
+ R VR L AE+ L TLT E A + Q+Q+ +
Sbjct: 1889 KLRSHEDTVR-LSAEKGRLDRTLTGAELELAEAQRQIQQLE 1928
Score = 50.4 bits (119), Expect = 8e-06
Identities = 61/292 (20%), Positives = 119/292 (40%), Gaps = 30/292 (10%)
Query: 231 QLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRL 290
QL V ++ + ++ LR+ +E + E++ ++ D D + + QR
Sbjct: 532 QLQVQDMRGRYEASQDLLGTLRKQLSDSE-SERRALEEQLQRLRDKTDGAMQAHEDAQRE 590
Query: 291 TASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAE 350
LR E L +E S L H + AQ +EL Q+ +Q +
Sbjct: 591 VQRLRSANELLSREKSN-------------LAHSLQVAQQQAEELRQEREKLQAAQEELR 637
Query: 351 ELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYS 410
RD+ +E ED ++++ + HR QLE++E +R + ++ S
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRRELE-RSHR------QLEQLEGKRSVLAKELVEVREALS 690
Query: 411 QSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLC 470
++ +++D L+AE+ E+ LT E + LE+ + + + + S S
Sbjct: 691 RATLQRDM-------LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA--SLQDSLSKL 741
Query: 471 SNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSIL 522
S L+ + + + + E + + G + +EAT + +E RL L
Sbjct: 742 SALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEEL 793
Score = 43.9 bits (102), Expect = 8e-04
Identities = 78/302 (25%), Positives = 125/302 (41%), Gaps = 54/302 (17%)
Query: 165 EEERAGLE---QRLRDQ--------QQAQERCQRLREDWEAGSLELLRLKDENYMIAMRL 213
E ER LE QRLRD+ + AQ QRLR + ELL + N ++++
Sbjct: 560 ESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLR-----SANELLSREKSNLAHSLQV 614
Query: 214 AQLSEEKNSAVLRSRD-LQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEK 272
AQ E+ + + R+ LQ A ++L+ + RLEEE
Sbjct: 615 AQQQAEE---LRQEREKLQAAQEELRRQRDRLEEE------------------------- 646
Query: 273 EPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSR 332
+ D V + +R E +R L +L EG + ++ E + L+ D +A+ +
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQL-EGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 333 -QELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEI 391
E K A + EL+ + ++D K L + K + ++AQLE
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLE-- 763
Query: 392 EKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAE--RDELLTTLTSLEGTKALLEV 449
E A+Q R R Q + ++ ++Q R + LE E R L +L E + LE
Sbjct: 764 --EEKSALQGRQR-QAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
Query: 450 QL 451
QL
Sbjct: 821 QL 822
Score = 42.4 bits (98), Expect = 0.002
Identities = 94/404 (23%), Positives = 162/404 (40%), Gaps = 37/404 (9%)
Query: 111 LTGQEPAQRCSMILDEEG-PEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERA 169
L Q A+R + + E L Q L E L L R Q ++ R R L+EE+A
Sbjct: 96 LLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVR-QSVELR-RQLQEEQA 153
Query: 170 GLEQRLRDQQQAQERCQRLREDWEAGSLEL-LRLKDENYMIAMRLAQLSEEKNSAVLRSR 228
++L+ Q+ Q+R +L + + L+ R + + R +L +++ S+
Sbjct: 154 SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQ 213
Query: 229 DLQLAVDQLKLKVSR---LEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRA 285
DL+ A+ +L+ + R L + A+LR A + E ++ D + R
Sbjct: 214 DLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTND----WTRCRK 269
Query: 286 ENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQ-KLHAVQG 344
E + A+ R +E S R+LL WR+ R+ + + K+ +
Sbjct: 270 ELEHREAAWRREEESFNAYFSNE----HSRLLL-----LWRQVVGFRRLVSEVKMFTERD 320
Query: 345 ELQWAEEL--RDQYLQEME-DLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQS 401
LQ EL + +QE L R + + + A + AQLE E+ RD+ ++
Sbjct: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLE--EQLRDKVLRE 378
Query: 402 RDRIQLQYSQSLIEKDQYR---------KQVRGLEAERDELLTTLTSLEGTKALLEVQLQ 452
+D Q Q L + D K++ E+D++ LT E +AL ++LQ
Sbjct: 379 KDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLT--EKLEALESLRLQ 436
Query: 453 RAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAA 496
+L + S SE L G E T +A+
Sbjct: 437 EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS 480
Score = 38.1 bits (87), Expect = 0.043
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 31/208 (14%)
Query: 130 EGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQA-------- 181
EG Q L +R+ +E + L Q+LQ +ER L++RL Q+A
Sbjct: 1809 EGQLQQLREVLRQRQEGEAAALNTVQKLQ-------DERRLLQERLGSLQRALAQLEAEK 1861
Query: 182 ---QERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLK 238
+ RL +D A L +++ E +LS EK +L + + +
Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921
Query: 239 LKVSRLEEECALLRRARGPPP---GAEEKEKEKEKEKE-------PDNVDLVSELRAENQ 288
++ +LE + +L ++ P A++++ E ++E E L + RA Q
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981
Query: 289 R---LTASLRELQEGLQQEASRPGAPGS 313
R L + L+ LQQE R AP S
Sbjct: 1982 RVRGLEEQVSTLKGQLQQELRRSSAPFS 2009
Score = 37.4 bits (85), Expect = 0.074
Identities = 89/412 (21%), Positives = 158/412 (38%), Gaps = 51/412 (12%)
Query: 111 LTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAG 170
L ++ + R + +EG + Q + ++ + +K + EQQL R LE
Sbjct: 148 LQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE----- 202
Query: 171 LEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDEN-------YMIAMRLAQLSEEKNSA 223
+QRLRD + +Q D E+ L+RL++E + AM QL + ++
Sbjct: 203 -QQRLRDTEHSQ--------DLESA---LIRLEEEQQRSASLAQVNAMLREQLDQAGSAN 250
Query: 224 VLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSEL 283
S D++ + LE A RR EE+ E + L+
Sbjct: 251 QALSEDIRKVTNDWTRCRKELEHREAAWRR--------EEESFNAYFSNEHSRLLLLWRQ 302
Query: 284 RAENQRLTASLRELQE----GLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKL 339
+RL + ++ E L E +R E L L R A+ + +K
Sbjct: 303 VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGL--GLSTGLRLAESRAEAALEKQ 360
Query: 340 HAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAI 399
+Q +L+ E+LRD+ L+E + L + +Q D D K ++ + +L K ++
Sbjct: 361 ALLQAQLE--EQLRDKVLREKD---LAQQQMQSDLD--KADLSARVTELGLAVKRLEKQN 413
Query: 400 QSRDRIQLQYSQSLIEKDQYRKQVR-GLEAERDELLTTLTSLEGTKALLEVQLQRAQGGT 458
+D++ ++ L + R Q + LE E E L + + L + L ++ G
Sbjct: 414 LEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQ-----QTLRDLAQAVLSDSESGV 468
Query: 459 CLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEAT 510
L + + S PSP + GP P S+ +T
Sbjct: 469 QLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSST 520
Score = 34.7 bits (78), Expect = 0.48
Identities = 84/386 (21%), Positives = 143/386 (37%), Gaps = 99/386 (25%)
Query: 118 QRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRD 177
+R +LD E + + R R + R + L R R+L+ E A LE ++
Sbjct: 1286 RRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE-ASLEVMRQE 1344
Query: 178 QQQAQERCQ------RLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQ 231
Q AQ + Q R RE GSLE R ++ + R +L E A L+
Sbjct: 1345 LQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLR 1404
Query: 232 LAVDQ----------LKLKVSRLEEECAL------LRRARG----------PPPGAEEKE 265
L+ + +++V R E L LRR G P PG+ ++
Sbjct: 1405 LSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARD 1464
Query: 266 KEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDW 325
E E N + S E G S+P +PG
Sbjct: 1465 APAEGSGEGLN--------------SPSTLECSPG-----SQPPSPGPA----------- 1494
Query: 326 REAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVL 385
+ +L + AV+G L+ ++LQE+ R+ Q++ D + + + +
Sbjct: 1495 --TSPASPDLDPE--AVRGALR-------EFLQEL-------RSAQRERDELRTQTSALN 1536
Query: 386 AQLEEIEKERDQAIQSRDRIQLQYSQS------------------LIEKDQYRKQVRGLE 427
QL E+E ERD A ++Q ++S ++++ R+ R
Sbjct: 1537 RQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR 1596
Query: 428 AERDELLTTLTSLEGTKALLEVQLQR 453
A D++ T SL+ T++ L ++
Sbjct: 1597 ATLDQVATLERSLQATESELRASQEK 1622
>gi|62243374 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 64.7 bits (156), Expect = 4e-10
Identities = 79/312 (25%), Positives = 142/312 (45%), Gaps = 31/312 (9%)
Query: 150 QLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMI 209
++ R Q+L R R L+E AG E+++++Q + +CQ ++ +A S L +D
Sbjct: 99 EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQ---QNLDAASKRLREKEDS---- 151
Query: 210 AMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKE 269
LAQ E N+ R +LQ +V +++V RLE E L+ + +K +E
Sbjct: 152 ---LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLD-----LQHKKCQE 203
Query: 270 KEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQ 329
++ + E RA++++ L + +Q+A+ SE + L LE + ++ +
Sbjct: 204 ANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR 263
Query: 330 DSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLE 389
+ L +++ G LQ EEL + LQ + K + +L R+ L E
Sbjct: 264 EESAHL-REMRETNGLLQ--EEL--EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE 318
Query: 390 EIEKERDQAIQ-----SRDRIQLQYSQSLIEKDQ---YRKQVRGLEAERDELLTTLTSLE 441
+++ +I+ SR ++LQ + L KD+ RGLE R +L L +
Sbjct: 319 RLDQTMGLSIRTPEDLSRFVVELQ-QRELALKDKNSAVTSSARGLEKARQQLQEELRQVS 377
Query: 442 GTKALLEVQLQR 453
G LLE + +R
Sbjct: 378 G--QLLEERKKR 387
Score = 42.4 bits (98), Expect = 0.002
Identities = 74/329 (22%), Positives = 147/329 (44%), Gaps = 34/329 (10%)
Query: 141 RRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLR----------E 190
R L++ R+ + + G +L+EE GL+++L Q++ QE L +
Sbjct: 257 RELKQLREESAHLREMRETNG-LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
Query: 191 DWE----AGSLELLRLKD-ENYMIAMRLAQLS-EEKNSAVLRS-RDLQLAVDQLKLKVSR 243
WE L + +D +++ ++ +L+ ++KNSAV S R L+ A QL+ ++ +
Sbjct: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
Query: 244 LEEECALLRRARGPPPGAEEKEKEKEK--EKEPDNVDLV-----SELRAE--NQRLTASL 294
+ + R+ R + +++ KE D + + SEL + +LT +
Sbjct: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
Query: 295 RELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQ-KLHAVQGELQWAEELR 353
RE ++ +Q+ S E L LE Q R ++ + +L ++ + AE+
Sbjct: 436 REAEDMVQKVHSHSAE--MEAQLSQALEE--LGGQKQRADMLEMELKMLKSQSSSAEQSF 491
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI-QLQYSQS 412
+E + LRLK L+ + + + AQLE + D QSR ++ + + +
Sbjct: 492 LFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD-QSRTKVLHMSLNPT 550
Query: 413 LIEKDQYRKQVRGLEAERDELLTTLTSLE 441
+ + + R+ L+AE + L L ++E
Sbjct: 551 SVARQRLREDHSQLQAECERLRGLLRAME 579
>gi|62243369 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 64.7 bits (156), Expect = 4e-10
Identities = 79/312 (25%), Positives = 142/312 (45%), Gaps = 31/312 (9%)
Query: 150 QLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMI 209
++ R Q+L R R L+E AG E+++++Q + +CQ ++ +A S L +D
Sbjct: 99 EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQ---QNLDAASKRLREKEDS---- 151
Query: 210 AMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKE 269
LAQ E N+ R +LQ +V +++V RLE E L+ + +K +E
Sbjct: 152 ---LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLD-----LQHKKCQE 203
Query: 270 KEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQ 329
++ + E RA++++ L + +Q+A+ SE + L LE + ++ +
Sbjct: 204 ANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR 263
Query: 330 DSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLE 389
+ L +++ G LQ EEL + LQ + K + +L R+ L E
Sbjct: 264 EESAHL-REMRETNGLLQ--EEL--EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE 318
Query: 390 EIEKERDQAIQ-----SRDRIQLQYSQSLIEKDQ---YRKQVRGLEAERDELLTTLTSLE 441
+++ +I+ SR ++LQ + L KD+ RGLE R +L L +
Sbjct: 319 RLDQTMGLSIRTPEDLSRFVVELQ-QRELALKDKNSAVTSSARGLEKARQQLQEELRQVS 377
Query: 442 GTKALLEVQLQR 453
G LLE + +R
Sbjct: 378 G--QLLEERKKR 387
Score = 42.4 bits (98), Expect = 0.002
Identities = 74/329 (22%), Positives = 147/329 (44%), Gaps = 34/329 (10%)
Query: 141 RRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLR----------E 190
R L++ R+ + + G +L+EE GL+++L Q++ QE L +
Sbjct: 257 RELKQLREESAHLREMRETNG-LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
Query: 191 DWE----AGSLELLRLKD-ENYMIAMRLAQLS-EEKNSAVLRS-RDLQLAVDQLKLKVSR 243
WE L + +D +++ ++ +L+ ++KNSAV S R L+ A QL+ ++ +
Sbjct: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
Query: 244 LEEECALLRRARGPPPGAEEKEKEKEK--EKEPDNVDLV-----SELRAE--NQRLTASL 294
+ + R+ R + +++ KE D + + SEL + +LT +
Sbjct: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
Query: 295 RELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQ-KLHAVQGELQWAEELR 353
RE ++ +Q+ S E L LE Q R ++ + +L ++ + AE+
Sbjct: 436 REAEDMVQKVHSHSAE--MEAQLSQALEE--LGGQKQRADMLEMELKMLKSQSSSAEQSF 491
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI-QLQYSQS 412
+E + LRLK L+ + + + AQLE + D QSR ++ + + +
Sbjct: 492 LFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD-QSRTKVLHMSLNPT 550
Query: 413 LIEKDQYRKQVRGLEAERDELLTTLTSLE 441
+ + + R+ L+AE + L L ++E
Sbjct: 551 SVARQRLREDHSQLQAECERLRGLLRAME 579
>gi|62243332 MAD1-like 1 protein [Homo sapiens]
Length = 718
Score = 64.7 bits (156), Expect = 4e-10
Identities = 79/312 (25%), Positives = 142/312 (45%), Gaps = 31/312 (9%)
Query: 150 QLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMI 209
++ R Q+L R R L+E AG E+++++Q + +CQ ++ +A S L +D
Sbjct: 99 EVDRNQELLTRIRQLQEREAGAEEKMQEQLERNRQCQ---QNLDAASKRLREKEDS---- 151
Query: 210 AMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKE 269
LAQ E N+ R +LQ +V +++V RLE E L+ + +K +E
Sbjct: 152 ---LAQAGETINALKGRISELQWSVMDQEMRVKRLESEKQELQEQLD-----LQHKKCQE 203
Query: 270 KEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQ 329
++ + E RA++++ L + +Q+A+ SE + L LE + ++ +
Sbjct: 204 ANQKIQELQASQEARADHEQQIKDLEQKLSLQEQDAAIVKNMKSELVRLPRLERELKQLR 263
Query: 330 DSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLE 389
+ L +++ G LQ EEL + LQ + K + +L R+ L E
Sbjct: 264 EESAHL-REMRETNGLLQ--EEL--EGLQRKLGRQEKMQETLVGLELENERLLAKLQSWE 318
Query: 390 EIEKERDQAIQ-----SRDRIQLQYSQSLIEKDQ---YRKQVRGLEAERDELLTTLTSLE 441
+++ +I+ SR ++LQ + L KD+ RGLE R +L L +
Sbjct: 319 RLDQTMGLSIRTPEDLSRFVVELQ-QRELALKDKNSAVTSSARGLEKARQQLQEELRQVS 377
Query: 442 GTKALLEVQLQR 453
G LLE + +R
Sbjct: 378 G--QLLEERKKR 387
Score = 42.4 bits (98), Expect = 0.002
Identities = 74/329 (22%), Positives = 147/329 (44%), Gaps = 34/329 (10%)
Query: 141 RRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLR----------E 190
R L++ R+ + + G +L+EE GL+++L Q++ QE L +
Sbjct: 257 RELKQLREESAHLREMRETNG-LLQEELEGLQRKLGRQEKMQETLVGLELENERLLAKLQ 315
Query: 191 DWE----AGSLELLRLKD-ENYMIAMRLAQLS-EEKNSAVLRS-RDLQLAVDQLKLKVSR 243
WE L + +D +++ ++ +L+ ++KNSAV S R L+ A QL+ ++ +
Sbjct: 316 SWERLDQTMGLSIRTPEDLSRFVVELQQRELALKDKNSAVTSSARGLEKARQQLQEELRQ 375
Query: 244 LEEECALLRRARGPPPGAEEKEKEKEK--EKEPDNVDLV-----SELRAE--NQRLTASL 294
+ + R+ R + +++ KE D + + SEL + +LT +
Sbjct: 376 VSGQLLEERKKRETHEALARRLQKRVLLLTKERDGMRAILGSYDSELTPAEYSPQLTRRM 435
Query: 295 RELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQ-KLHAVQGELQWAEELR 353
RE ++ +Q+ S E L LE Q R ++ + +L ++ + AE+
Sbjct: 436 REAEDMVQKVHSHSAE--MEAQLSQALEE--LGGQKQRADMLEMELKMLKSQSSSAEQSF 491
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI-QLQYSQS 412
+E + LRLK L+ + + + AQLE + D QSR ++ + + +
Sbjct: 492 LFSREEADTLRLKVEELEGERSRLEEEKRMLEAQLERRALQGDYD-QSRTKVLHMSLNPT 550
Query: 413 LIEKDQYRKQVRGLEAERDELLTTLTSLE 441
+ + + R+ L+AE + L L ++E
Sbjct: 551 SVARQRLREDHSQLQAECERLRGLLRAME 579
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 63.9 bits (154), Expect = 7e-10
Identities = 71/308 (23%), Positives = 135/308 (43%), Gaps = 29/308 (9%)
Query: 133 TQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQA-QERCQRLRED 191
T L E+ + +++++ Q L R EE E+RLR+Q++ +E+ +RL E
Sbjct: 166 TNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQEERLCEQ 225
Query: 192 WEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALL 251
E + RL+++ + + +L E + + L ++L+ + RL E+ L
Sbjct: 226 EERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERL 285
Query: 252 RRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAP 311
+++E+ +E+E + LR + +RL L+E ++ + P
Sbjct: 286 C-----------EQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLP 334
Query: 312 GSERILLDI---LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQ--------YLQEM 360
G ER+L ++ LE + R+ + R ++L EL E LR Q LQE+
Sbjct: 335 GQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQEL 394
Query: 361 EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR 420
E LR R L+ + + A + EE+ E ++ +QL+ ++K
Sbjct: 395 ERLRELERMLELGWEALYEQRAEPRSGFEELNNE------NKSTLQLEQQVKELKKSGGA 448
Query: 421 KQVRGLEA 428
++ RG E+
Sbjct: 449 EEPRGSES 456
Score = 41.6 bits (96), Expect = 0.004
Identities = 67/324 (20%), Positives = 140/324 (43%), Gaps = 50/324 (15%)
Query: 132 LTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLRED 191
LT+ + + VR +E +K ++ Q+L GR L +L++Q + L +
Sbjct: 108 LTENINSLVRTSKEEKKHEIHLVQKL---GRSLF--------KLKNQT-----AEPLAPE 151
Query: 192 WEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALL 251
AG ++ +L+DE + L + + + V ++ L L ++R +EE
Sbjct: 152 PPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSL--------LNRRQEE---- 199
Query: 252 RRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAP 311
R R E+E E+ +E+E + LR + +RL RE +E L ++ R
Sbjct: 200 -RLREQEERLREQE-ERLREQEERLCEQEERLREQEERL----REQEERLCEQEER---- 249
Query: 312 GSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQ 371
+ EH+ R + + LC++ ++ + + E ++ ++ E LR + L
Sbjct: 250 --------LREHEERLCEQE-ERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLC 300
Query: 372 KDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERD 431
+ + + + + Q E + ++ ++ + +L + L+E+ + + + E++
Sbjct: 301 EQEERLREQEERLCEQEERLREQEERLCEQE---KLPGQERLLEEVEKLLEQERRQEEQE 357
Query: 432 ELLTTLTSLEGTKALLEVQLQRAQ 455
LL LE + LLE + R Q
Sbjct: 358 RLLERERLLEEVEELLEQERLRQQ 381
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 63.5 bits (153), Expect = 1e-09
Identities = 69/335 (20%), Positives = 149/335 (44%), Gaps = 37/335 (11%)
Query: 145 EARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQR--LREDWEAGSLELL-- 200
+A+K L++ ++++ + LE + +Q+ ++Q++ Q+ + + SL+ L
Sbjct: 754 KAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLT 813
Query: 201 ----RLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVD----QLKLKVSRLEEECALLR 252
+K EN L L + + ++ R L A++ +L L +++LE
Sbjct: 814 ESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLE------- 866
Query: 253 RARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTAS----------LRELQEGLQ 302
G +EK +++ K+K + L EL+ +N L + L++ Q+ LQ
Sbjct: 867 -------GNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQ 919
Query: 303 QEASRPGAPGSERILLDI-LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEME 361
QE R G + L+ + +E Q R+ +KL ++ + + A D Q++
Sbjct: 920 QETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVI 979
Query: 362 DLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRK 421
+L R ++ + D YK ++ + ++ ++++ + ++ + Q+ E ++
Sbjct: 980 ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTN 1039
Query: 422 QVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQG 456
V+ LE + T LT + +LE +LQ A G
Sbjct: 1040 AVKELEKLQHSTETELTEALQKREVLETELQNAHG 1074
Score = 45.8 bits (107), Expect = 2e-04
Identities = 77/349 (22%), Positives = 153/349 (43%), Gaps = 46/349 (13%)
Query: 154 EQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRL 213
E ++ A+ +VL E LEQ Q+ E+ Q L+E E E ++LK + +
Sbjct: 297 EAEVSAQDKVLREAENKLEQ---SQKMVIEKEQSLQESKE----ECIKLKVDLLEQTKQG 349
Query: 214 AQLSEEKNSAVLRSRDLQLAVDQLKLKVS----RLEEECALLRRARGPPPGAEEKEKEKE 269
+ ++N A+ + +L A Q K KV+ +++ E +L R EKE +
Sbjct: 350 KRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILER------NLTNCEKENK 403
Query: 270 KEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQ 329
+ +E + ++E + L LR+L+E G E++ + +++ AQ
Sbjct: 404 RLQERCGL-----YKSELEILKEKLRQLKE--------ENNNGKEKLRIMAVKNSEVMAQ 450
Query: 330 --DSRQELCQKLHAVQGELQWAEE-LRDQY--LQEMEDLRLKHRTLQKDCDLYKHRMATV 384
+SRQ + + ++ EL+ +E LRD++ + E +L+++ + DL + + +
Sbjct: 451 LTESRQSILK----LESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESS 506
Query: 385 LAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQY-RKQVRGLE-AERDELLTTLTSLEG 442
+L +EK Q R+ + S + + K+ R + E ++L+ ++ L
Sbjct: 507 RVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLV--ISELRI 564
Query: 443 TKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEF---PSPLGG 488
A+ E ++Q+ + S C++ + LS P LGG
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGG 613
Score = 45.1 bits (105), Expect = 4e-04
Identities = 71/354 (20%), Positives = 138/354 (38%), Gaps = 70/354 (19%)
Query: 134 QFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWE 193
Q L E R E +Q + E+Q+ + L+++R ++LR + +E+C+ + +
Sbjct: 916 QMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLR---KMEEKCESAAHEAD 972
Query: 194 AGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRR 253
+++ L +R +++ +DQ K ++S++E+E L+R
Sbjct: 973 LKRQKVIELTG---------------------TARQVKIEMDQYKEELSKMEKEIMHLKR 1011
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNVDLV-SELRAENQRLTASLRELQEGLQQEASRPGAPG 312
+ K +D++ + + E ++ T +++EL++
Sbjct: 1012 ------------DGENKAMHLSQLDMILDQTKTELEKKTNAVKELEK------------- 1046
Query: 313 SERILLDILEHDWREAQDSRQELCQKLHAVQGE----LQWAEELRDQYLQEMEDLRLKHR 368
L E + EA R+ L +L GE L+ +ELRD + L K+
Sbjct: 1047 ----LQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYT 1102
Query: 369 TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEA 428
T+ KD + ++ E DQA++ R+ Q + + D ++ RG
Sbjct: 1103 TI-KDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG--- 1158
Query: 429 ERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEF 482
E+ + LEGT E++L+ C K S + N EF
Sbjct: 1159 ---EMEQKIIKLEGTLEKSELELKE-----CNKQIESLNDKLQNAKEQLREKEF 1204
Score = 43.9 bits (102), Expect = 8e-04
Identities = 59/271 (21%), Positives = 117/271 (43%), Gaps = 28/271 (10%)
Query: 198 ELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGP 257
E+ L+++ + + A L + +S + + + + Q + KVS LE ++
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESA----QQQAAS 285
Query: 258 PPGAEEKEKEKEKE-KEPDNVDLVSELRAENQRLTASLRE--LQEG-----------LQQ 303
P EE+ E E D V +E + E + +E LQE L+Q
Sbjct: 286 VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345
Query: 304 EASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDL 363
A L E + Q ++++ +KL VQ E EE+ ++ L E
Sbjct: 346 TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAE----EEILERNLTNCEK- 400
Query: 364 RLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQV 423
+++ LQ+ C LYK + + +L ++++E + + + ++ S+ + + + R+ +
Sbjct: 401 --ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 458
Query: 424 RGLEAE---RDELLTTLTSLEGTKALLEVQL 451
LE+E +DE+L SL L+V++
Sbjct: 459 LKLESELENKDEILRDKFSLMNENRELKVRV 489
Score = 42.0 bits (97), Expect = 0.003
Identities = 83/393 (21%), Positives = 163/393 (41%), Gaps = 79/393 (20%)
Query: 112 TGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQRE--------QQLQARGRV 163
T E ++ + + + E + T+ +TE + RE +++LQ +QLQ V
Sbjct: 1030 TKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
Query: 164 LEEERAGLEQR---LRDQQQAQERCQRLREDWEAGSLELLR-LKDENYMIAMRLAQLSE- 218
L++ + LE++ ++D C+ ED + LE+ + LK+ N+ + R AQ++
Sbjct: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL 1149
Query: 219 ----------------------EKNSAVLR--SRDLQLAVDQLKLKVSRL-EEECALLRR 253
EK+ L+ ++ ++ D+L+ +L E+E +L+
Sbjct: 1150 DMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQN 1209
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNV----------------DLVSELRAENQRLTASLREL 297
+ +E E+ +++ KE ++V DL ELR +++ S EL
Sbjct: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTEL 1269
Query: 298 QEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHA-----------VQGEL 346
E Q+ L+ ++ +E L ++L A +Q E+
Sbjct: 1270 AEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEI 1329
Query: 347 Q----WAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSR 402
+ E L++ Y EM + H + D K + + QLE+ + E ++A +
Sbjct: 1330 KKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEA---Q 1386
Query: 403 DRIQLQYSQSLIEKDQYRKQVRGLEAERDELLT 435
D + +L ++ Q R +V +EA + LLT
Sbjct: 1387 DTV-----SNLHQQVQDRNEV--IEAANEALLT 1412
Score = 39.7 bits (91), Expect = 0.015
Identities = 64/317 (20%), Positives = 135/317 (42%), Gaps = 26/317 (8%)
Query: 141 RRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELL 200
+ ++ +K ++ +++QA +LE E ++ ++ QERC + + E +L
Sbjct: 368 KAFQQYKKKVAEKLEKVQAEEEILERNLTNCE---KENKRLQERCGLYKSELEILKEKLR 424
Query: 201 RLKDENYMIAMRLAQLSEEKNSAVL----RSRDLQLAVD-QLKLKVSRLEEECALLRRAR 255
+LK+EN +L ++ KNS V+ SR L ++ +L+ K L ++ +L+
Sbjct: 425 QLKEENNNGKEKL-RIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMN--- 480
Query: 256 GPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSER 315
E +E + + + +DL + E + LR L++ + Q + G +
Sbjct: 481 ------ENRELKVRVAAQNERLDLCQQ---EIESSRVELRSLEKIISQLPLKRELFGFKS 531
Query: 316 ILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCD 375
L + +D C+ V EL+ +++ +Q++ ++ Q
Sbjct: 532 YLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLIT 591
Query: 376 LYKHRMATVLAQLE-EIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELL 434
+ ++ L+ LE E K + + Q Q++ + QY K+ + L +EL
Sbjct: 592 CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMN----KQYEKERQRLVTGIEELR 647
Query: 435 TTLTSLEGTKALLEVQL 451
T L +E + L+V +
Sbjct: 648 TKLIQIEAENSDLKVNM 664
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 62.4 bits (150), Expect = 2e-09
Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 23/297 (7%)
Query: 134 QFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWE 193
Q LMT R KS ++R L+ + E+ER LE R ++ Q R Q++ ED +
Sbjct: 503 QMLMTPTSAPRSVMKSFIKRNTPLRMDPK--EKERQRLENLRRKEEAEQLRRQKVEED-K 559
Query: 194 AGSLELLRLKDENYMIAM-----RLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEEC 248
LE ++LK E + + R+ Q+ EEK + + Q+ K K RL EE
Sbjct: 560 RRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQI-EQKFAQIDEKTEKAKEERLAEEK 618
Query: 249 ALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRP 308
A + A E + K++E+ + + E R + L E QE L++ A
Sbjct: 619 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAA--- 675
Query: 309 GAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHR 368
+ L + E + RE + QE ++ Q + +L +Q + R +
Sbjct: 676 ----EAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ------ERRREQE 725
Query: 369 TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRG 425
LQ + +L + A L Q E++++E ++ + ++ +L Q E+++ K+ G
Sbjct: 726 RLQAERELQEREKALRL-QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG 781
Score = 57.0 bits (136), Expect = 9e-08
Identities = 68/272 (25%), Positives = 122/272 (44%), Gaps = 31/272 (11%)
Query: 137 MTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGS 196
+ +RR EA QL+R++ + + R LEE + E+RLR QA+ER ++++E
Sbjct: 538 LENLRRKEEAE--QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE------ 589
Query: 197 LELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK-VSRLEEECALLRRAR 255
++ I + AQ+ E+ A ++ +LA ++ K K ++ EE R+
Sbjct: 590 -------EKKKQIEQKFAQIDEKTEKA----KEERLAEEKAKKKAAAKKMEEVEARRKQE 638
Query: 256 GPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSER 315
++E+E+ + + + E E R A + L E +QE ER
Sbjct: 639 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 698
Query: 316 ILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCD 375
+ E + RE + RQ Q+ Q LQ EL+++ + LRL+ LQ++ +
Sbjct: 699 REQERREQERREQE--RQLAEQERRREQERLQAERELQER----EKALRLQKEQLQRELE 752
Query: 376 LYK-----HRMATVLAQLEEIEKERDQAIQSR 402
K R+A Q E+ +K ++ A S+
Sbjct: 753 EKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 784
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/244 (22%), Positives = 105/244 (43%), Gaps = 24/244 (9%)
Query: 74 RVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLT 133
++ R RL +L+ R + E E + + F + + + + +E+ +
Sbjct: 567 KLKREERLRKVLQARER--VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 624
Query: 134 QFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWE 193
M EV EAR+ Q + ++L R L++E + Q++ +E +RLR+ E
Sbjct: 625 AKKMEEV----EARRKQEEEARRL----RWLQQEEEERRHQELLQKKKEEEQERLRKAAE 676
Query: 194 AGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRR 253
A L R ++ + +E+ R ++ QLA + + + RL+ E L R
Sbjct: 677 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGS 313
+ E+ ++E E++K+ + E QRL R+LQE +QE A G+
Sbjct: 737 EKALRLQKEQLQRELEEKKK----------KEEQQRLAE--RQLQE--EQEKKAKEAAGA 782
Query: 314 ERIL 317
+ L
Sbjct: 783 SKAL 786
Score = 42.0 bits (97), Expect = 0.003
Identities = 59/236 (25%), Positives = 99/236 (41%), Gaps = 18/236 (7%)
Query: 228 RDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAEN 287
R+ L +D + + RLE LRR AE+ ++K +E + ++ V R E
Sbjct: 522 RNTPLRMDPKEKERQRLEN----LRRKEE----AEQLRRQKVEEDKRRRLEEVKLKREER 573
Query: 288 QRLTASLRELQEGLQQEASRPGAPGSERI---LLDILEHDWREAQDSRQELCQKLHAVQG 344
R RE E +++E + +I E E + ++ +K+ V+
Sbjct: 574 LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA 633
Query: 345 ELQWAEELRD-QYLQEMEDLRLKHRTLQKDCDLYKHRM-----ATVLAQLEEIEKERDQA 398
+ EE R ++LQ+ E+ R LQK + + R+ A LA+ E E+ +
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693
Query: 399 IQSRDRIQLQYSQSLIEKD-QYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQR 453
+ R Q + Q E++ Q +Q R E ER + L E L + QLQR
Sbjct: 694 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 749
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 62.0 bits (149), Expect = 3e-09
Identities = 71/315 (22%), Positives = 138/315 (43%), Gaps = 20/315 (6%)
Query: 127 EGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAG----LEQRLRDQQQAQ 182
E E Q ++ E R++ L+ + LE+E+A L+Q+L+ +A+
Sbjct: 572 EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
Query: 183 ERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKL--- 239
+ Q + EL R K E + A+ + + A + +LQL +Q K
Sbjct: 632 DSAQTSVTQAQREKAELSR-KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Query: 240 -----KVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASL 294
+ +L+E+ L+ + G+ E+EK + + + +SEL+AE + L
Sbjct: 691 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 295 RELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRD 354
+ ++ L++E R G G E L + E E + R+EL + + A AE +
Sbjct: 751 KRERKELEEE--RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA----QHTAESECE 804
Query: 355 QYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQL-EEIEKERDQAIQSRDRIQLQYSQSL 413
Q ++E+ R ++ Q++ Y L L EE EK R + ++++++ S S
Sbjct: 805 QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE 864
Query: 414 IEKDQYRKQVRGLEA 428
++ + + ++ L A
Sbjct: 865 LQISRQQNELAELHA 879
Score = 53.9 bits (128), Expect = 8e-07
Identities = 76/375 (20%), Positives = 156/375 (41%), Gaps = 53/375 (14%)
Query: 130 EGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRD----QQQAQERC 185
E LT L +++ ++ + + Q ++++ L EE L +LR+ QQ Q+
Sbjct: 286 ESLTMRLHETLKQCQDLKTEKSQMDRKINQ----LSEENGDLSFKLREFASHLQQLQDAL 341
Query: 186 QRLREDWEAGSLELLR------------------LKDENYMIAMRLAQLSE--------- 218
L E+ + E L L+++N ++ +L+QL E
Sbjct: 342 NELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNP 401
Query: 219 --EKNSA---VLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKE 273
EK VL+ L+ L ++L+ +L RG E+ +E++
Sbjct: 402 PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEK 461
Query: 274 PDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAP----GSERILLD--ILEHDWRE 327
L+++L++ L+ + EL++ Q +R A SE L+ I + D
Sbjct: 462 QQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQEL 521
Query: 328 A---QDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATV 384
A Q ++++ Q +Q + Q ++ LR Q Q L+ K + L++ + +
Sbjct: 522 AGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581
Query: 385 LAQLEEIEKERDQAIQSRD----RIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL 440
QL +ER+ +++ RD +++ + + + ++Q++ RD T++T
Sbjct: 582 AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641
Query: 441 EGTKALLEVQLQRAQ 455
+ KA L +++ Q
Sbjct: 642 QREKAELSRKVEELQ 656
Score = 45.1 bits (105), Expect = 4e-04
Identities = 75/355 (21%), Positives = 138/355 (38%), Gaps = 65/355 (18%)
Query: 123 ILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQ 182
+ DE + + E R+L + +Q+ QQ R +L E++A ++ ++ +
Sbjct: 223 LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELR 282
Query: 183 ERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVS 242
++ + L + LK E + ++ QLSEE + R+ + QL+ ++
Sbjct: 283 DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALN 342
Query: 243 RLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSE-LRAENQRLTASLRELQEGL 301
L EE + + E EK+ + EKE + L +N+ L L +L+E L
Sbjct: 343 ELTEEHSKATQ--------EWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHL 394
Query: 302 QQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEME 361
Q P Q+ V G++ E L+ QE
Sbjct: 395 SQLQDNPP---------------------------QEKGEVLGDVLQLETLK----QEAA 423
Query: 362 DLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRK 421
L + LQ A++E +E ER Q Q ++ L E+ + +
Sbjct: 424 TLAANNTQLQ--------------ARVEMLETERGQ----------QEAKLLAERGHFEE 459
Query: 422 QVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSST 476
+ + L + +L +++++L K LE Q +A G AS S + L++T
Sbjct: 460 EKQQLSSLITDLQSSISNLSQAKEELE-QASQAHGARLTAQVASLTSELTTLNAT 513
Score = 44.7 bits (104), Expect = 5e-04
Identities = 70/344 (20%), Positives = 140/344 (40%), Gaps = 37/344 (10%)
Query: 132 LTQFLMTEVRRLREARKSQLQREQQLQA--RGRVLEEERA-GLEQRLRDQQQAQER-CQR 187
L Q L E + + +L++ +Q R +L +R G LR + QER Q+
Sbjct: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQ 1425
Query: 188 LREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLK------LKV 241
LR + + + +L LK + ++A L E N L + L++ +DQ + L
Sbjct: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN---LGRQFLEVELDQAREKYVQELAA 1482
Query: 242 SRLEEECALLRRARGPPP-------------GAEEKEKEKEKEKEPDNVDLVSELRAENQ 288
R + E L R GA+ K E+ + + + L +++
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 289 RLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQW 348
++++E ++ A A ++ L ++ E+Q Q L +L+ +Q +L
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602
Query: 349 AEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQ 408
E+ + Y +ME + + ++ + L LE+++KE + +R+ +
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQ----NQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
Query: 409 YSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQ 452
Q+ ++ + + R L A+ + SLE A + QL+
Sbjct: 1659 LQQAGLKTKEAEQTCRHLTAQ-------VRSLEAQVAHADQQLR 1695
Score = 42.0 bits (97), Expect = 0.003
Identities = 108/498 (21%), Positives = 206/498 (41%), Gaps = 66/498 (13%)
Query: 4 RAEAGEAEEE-AGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQD- 61
R E EA+E+ AG S SE + + + LARAL + +R ++ D+
Sbjct: 846 RQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQ-EKEVRAQKLADDLST 904
Query: 62 -EEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEF------YYPEHFTLLTGQ 114
+E++ +T + RL ++R G++ A E ++ PE L Q
Sbjct: 905 LQEKMAATSK------EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW---LEEQ 955
Query: 115 EPAQRCSMILDEEGPEGLTQFLMTEVRRLREA-RKSQLQREQQ-----------LQARGR 162
+ Q CS + E + + E+ RLR A +SQ Q++++ Q RGR
Sbjct: 956 QGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGR 1015
Query: 163 VLEE------ERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQL 216
+ RA LE RL++ Q ++ A +L KD+ LA+L
Sbjct: 1016 AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE------LAKL 1069
Query: 217 SEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDN 276
+ + + +L+ V QLK ++++ E+E A A+ G E K + +
Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAE- 1128
Query: 277 VDLVSELRAENQRLTASLRELQEGLQQE-ASRPGAPGSERILLDILEHDWREAQDSRQEL 335
VS+L + Q+ L+ L+ E ASR + L LE +E S+ L
Sbjct: 1129 ---VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
Query: 336 C---QKLHAVQGELQWAEELRDQY-------LQEMEDLRLKHRTLQKDCDLYKHRMATVL 385
++L A + ++Q + D++ QE E +L+++ + ++
Sbjct: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKE 1245
Query: 386 AQLEEIEK----ERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAE----RDELLTTL 437
+ +E+++ E +++ + +R++L +++ + ++ L E R+E
Sbjct: 1246 GESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
Query: 438 TSLEGTKALLEVQLQRAQ 455
+ E + L Q +RA+
Sbjct: 1306 VASENLRQELTSQAERAE 1323
Score = 32.0 bits (71), Expect = 3.1
Identities = 39/197 (19%), Positives = 77/197 (39%), Gaps = 10/197 (5%)
Query: 259 PGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILL 318
P + + +K+ E N D + AEN++L +QQ R ++
Sbjct: 212 PQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAAS 271
Query: 319 DILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYK 378
+ + E +D + L +LH + Q + + Q +++ L ++ L +
Sbjct: 272 PLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 379 HRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLT 438
+ + L E+ +E +A Q Q Q + L Q +K + E++E+
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE----EKNEI----- 382
Query: 439 SLEGTKALLEVQLQRAQ 455
L+G + LE L + Q
Sbjct: 383 -LQGKLSQLEEHLSQLQ 398
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 62.0 bits (149), Expect = 3e-09
Identities = 83/320 (25%), Positives = 146/320 (45%), Gaps = 54/320 (16%)
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAG 195
L E + L+EA + L Q + R L + + LEQ++ D + + E+ ++LR D E
Sbjct: 1041 LTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERA 1100
Query: 196 SLEL---LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEE----C 248
+L L+L E+ A + Q EEK L+ +D +L+ QL L R+E+E
Sbjct: 1101 KRKLEGDLKLTQESVADAAQDKQQLEEK----LKKKDSELS--QLSL---RVEDEQLLGA 1151
Query: 249 ALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTAS--LRELQEGL----- 301
+ ++ + AEE E+E E E+ + R E QR A+ L EL E L
Sbjct: 1152 QMQKKIKELQARAEELEEELEAER-------AARARVEKQRAEAARELEELSERLEEAGG 1204
Query: 302 ----QQEASRPGAPGSERILLDI----LEHD------WREAQDSRQELCQKLHAVQGELQ 347
Q+E R R+ ++ L H+ R+ + EL +++ ++Q Q
Sbjct: 1205 ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQ 1264
Query: 348 WAEELRDQYLQEMEDLRLKHRTL-------QKDCDLYKHRMATVLAQLEEIEKERDQAIQ 400
E+ + + E++DL TL +K C Y+ +++ ++EE++++ A
Sbjct: 1265 KLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADAST 1324
Query: 401 SRDRIQL---QYSQSLIEKD 417
R R+Q + S+ L EK+
Sbjct: 1325 QRGRLQTESGELSRLLEEKE 1344
Score = 51.6 bits (122), Expect = 4e-06
Identities = 75/310 (24%), Positives = 137/310 (44%), Gaps = 33/310 (10%)
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQ----QAQERCQRL--- 188
L E+R LR A + + Q+L+ + +E+ L +L+ +Q A+ERC L
Sbjct: 901 LRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKS 960
Query: 189 REDWEAGSLELL-RLKDE---NYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKL----- 239
+ E EL RL+DE N +A R +L +E DL+L + + +
Sbjct: 961 KVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQAT 1020
Query: 240 --KVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPD---NVDLVSELRAENQRLTASL 294
KV L EE A L + ++ +E ++ D D VS L RL +
Sbjct: 1021 ENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQV 1080
Query: 295 RELQEGLQQEAS-RPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELR 353
+L+ L+QE R ++R LE D + Q+S + Q ++ +L+ +
Sbjct: 1081 EDLECSLEQEKKLRMDTERAKR----KLEGDLKLTQESVADAAQDKQQLEEKLKKKDSEL 1136
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSL 413
Q +ED +L +QK ++ + A+ EE+E+E + +R R++ Q +++
Sbjct: 1137 SQLSLRVEDEQLLGAQMQK-------KIKELQARAEELEEELEAERAARARVEKQRAEAA 1189
Query: 414 IEKDQYRKQV 423
E ++ +++
Sbjct: 1190 RELEELSERL 1199
Score = 51.6 bits (122), Expect = 4e-06
Identities = 77/361 (21%), Positives = 144/361 (39%), Gaps = 62/361 (17%)
Query: 137 MTEVRRLREARKSQLQRE-QQLQARGRVLEEERAGLEQRLR----------------DQQ 179
+ VR+ E KS+L+ E L A L +A E+ R +Q
Sbjct: 1259 LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 1318
Query: 180 QAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQ--- 236
A QR R E+G EL RL +E + ++QLS K A +L+ +++
Sbjct: 1319 LADASTQRGRLQTESG--ELSRLLEEKECL---ISQLSRGKALAAQSLEELRRQLEEESK 1373
Query: 237 ----LKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEK----------------EPDN 276
L V L +C LLR EE E + E ++ E D
Sbjct: 1374 AKSALAHAVQALRHDCDLLREQH-----EEEAEAQAELQRLLSKANAEVAQWRSKYEADA 1428
Query: 277 VDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELC 336
+ EL ++L L+E +EG++ ++ + ++ L E++D EL
Sbjct: 1429 IQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQT------ESEDVTLELE 1482
Query: 337 QKLHAVQGELQWAEELRDQYLQE-MEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKER 395
+ A A + + ++L+ +E+ R + +Q++ + + + +L +
Sbjct: 1483 RATSAAA-----ALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGH 1537
Query: 396 DQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
++A+++ + ++ + E QV EL T +LEG K+ ++ L+ A+
Sbjct: 1538 EEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAE 1597
Query: 456 G 456
G
Sbjct: 1598 G 1598
Score = 47.0 bits (110), Expect = 9e-05
Identities = 58/299 (19%), Positives = 119/299 (39%), Gaps = 28/299 (9%)
Query: 184 RCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSR 243
R + E+ A EL L+ + +L E S DL L + + ++
Sbjct: 890 RSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLAD 949
Query: 244 LEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLV----------SELRAENQRLTAS 293
EE C LL +++ G ++ E+ +++E N DL +EL+ + L +
Sbjct: 950 AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLT 1009
Query: 294 LRELQEGLQQEASRPGAPGSERILLD----ILEHDWREAQDSRQELCQKLHAVQGELQWA 349
L + ++ Q ++ E LD L + + Q++ Q+ L A + +
Sbjct: 1010 LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSAL 1069
Query: 350 EELRDQYLQEMEDLRLK--------------HRTLQKDCDLYKHRMATVLAQLEEIEKER 395
+ + + Q++EDL R L+ D L + +A +++E++
Sbjct: 1070 TKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKL 1129
Query: 396 DQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRA 454
+ ++ L+ + Q +K+++ L+A +EL L + +A +E Q A
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEA 1188
Score = 46.2 bits (108), Expect = 2e-04
Identities = 66/314 (21%), Positives = 128/314 (40%), Gaps = 44/314 (14%)
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAG 195
L TE+ RLR + L+ + L+ + L+EE + L ++ ++ + ++ ++ E
Sbjct: 1526 LGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGE 1585
Query: 196 SLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRL----EEECALL 251
E+ +E A +L E K + QL + Q+K +V R +EECA L
Sbjct: 1586 KSEIQAALEE----AEGALELEETKTLRI------QLELSQVKAEVDRKLAEKDEECANL 1635
Query: 252 RRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLR--------ELQEGLQQ 303
RR ++ E L +E RA N+ L + ELQ G
Sbjct: 1636 RR-------------NHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG--- 1679
Query: 304 EASRPG--APGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEME 361
A+R A + R++ L+ + + +D Q L +LH + Q E E+E
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEE-QAGRDEEQRLAAELHE---QAQALERRASLLAAELE 1735
Query: 362 DLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRK 421
+LR ++ L + + +L + + + + +++ +Q E ++ +
Sbjct: 1736 ELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQ 1795
Query: 422 QVRGLEAERDELLT 435
+ R E + + +T
Sbjct: 1796 ERREAEEKAKKAIT 1809
Score = 42.4 bits (98), Expect = 0.002
Identities = 94/470 (20%), Positives = 180/470 (38%), Gaps = 64/470 (13%)
Query: 3 GRAEAGEAEEEAGAGSGSEAE-EDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQD 61
G+A A ++ EE E++ + AL ++ +RH C ++ EQ
Sbjct: 1353 GKALAAQSLEELRRQLEEESKAKSALAHAVQALRH----------------DCDLLREQH 1396
Query: 62 EEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCS 121
EEE + +++ ++ + R K +A E + L QE
Sbjct: 1397 EEEAEAQAELQRLLSKANA--EVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA----- 1449
Query: 122 MILDEEGPEGL----TQFLMTEVRRLREARKSQLQREQQLQARGRVLEEER---AGLEQR 174
EEG E + ++R E+ L+ E+ A + +++R LE+R
Sbjct: 1450 ----EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEER 1505
Query: 175 LRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQ--- 231
R +++ Q + + + EL RL+ + L L E + DL
Sbjct: 1506 RRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQV 1565
Query: 232 ----LAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAEN 287
++ +L+ LE E + ++ A GA E E+ K + + +S+++AE
Sbjct: 1566 SLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE----LSQVKAEV 1621
Query: 288 QRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQ 347
R A E L++ R A S + LD EA ++++ L+ ++ +L
Sbjct: 1622 DRKLAEKDEECANLRRNHQR--AVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 348 WA---------------EELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIE 392
A +L+++ E+ RL L + + R + + A+LEE+
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLA-AELHEQAQALERRASLLAAELEELR 1738
Query: 393 KERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEG 442
+Q +SR + + ++ + Q GL ++ +L L L G
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSG 1788
Score = 37.0 bits (84), Expect = 0.096
Identities = 60/277 (21%), Positives = 107/277 (38%), Gaps = 28/277 (10%)
Query: 113 GQEPAQRCSMILDEEGP--EGLTQFLMTEVRRLREA-----RKSQLQREQQLQARGRV-- 163
G++ QR + L E+ E L E+ LR A R +L ++ L+A R+
Sbjct: 1705 GRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNL 1764
Query: 164 LEEERAGLEQRLRDQQ--------QAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQ 215
L + GL + + + + +E Q RE E + K AM +
Sbjct: 1765 LHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE-------KAKKAITDAAMMAEE 1817
Query: 216 LSEEKNSAVLRSRDLQLAVDQLKLKVSRLEE-ECALLRRARGPPPGAEEKEKEKEKEKEP 274
L +E++++ R + ++ +RLEE E A LR + E K +E E E +
Sbjct: 1818 LKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDA 1877
Query: 275 D---NVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDS 331
+ + + + +R +R+ + +E + A + + + + EA+
Sbjct: 1878 EQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQ 1937
Query: 332 RQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHR 368
K Q EL AEE D + LR + R
Sbjct: 1938 ANTNLAKYRKAQHELDDAEERADMAETQANKLRARTR 1974
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 61.6 bits (148), Expect = 4e-09
Identities = 73/335 (21%), Positives = 137/335 (40%), Gaps = 42/335 (12%)
Query: 130 EGLTQFLMTEVRRLREAR----KSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERC 185
+G + LM +V R K Q ++ L EE +A LE L++ +
Sbjct: 1423 QGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482
Query: 186 QRLREDWEAGSLELLRLKDENYMIAMRLAQLSEE--------------KNSAVLRSRDLQ 231
+L+ +E +L +K EN + +A L+E+ + L D+Q
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Query: 232 LAVDQLKLKVSRLEEECALLR---RARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQ 288
LA+++ + + EE +LR + K EK++E E + +
Sbjct: 1543 LALEEAEAALEH--EEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQS 1600
Query: 289 RLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQW 348
L A +R E ++ + G L+ +E A E + L +VQG+L+
Sbjct: 1601 ALDAEVRSRNEAIRLKKKMEGD-------LNEIEIQLSHANRQAAETLKHLRSVQGQLKD 1653
Query: 349 AEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKER----DQAIQSRDR 404
+ D L+ EDL+ + +++ +L + + + A LE+ E+ R + + S +R
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER 1713
Query: 405 IQLQYSQSL--------IEKDQYRKQVRGLEAERD 431
+QL ++Q+ +E D + Q +A RD
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD 1748
Score = 58.9 bits (141), Expect = 2e-08
Identities = 73/353 (20%), Positives = 151/353 (42%), Gaps = 48/353 (13%)
Query: 124 LDEEGPEGLTQFLMTEVRRL------REARKSQLQREQQLQARGRVLEEERAGLEQRLRD 177
L+E G TQ + + R R+ ++ LQ E + A + + A L +++ +
Sbjct: 1151 LEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDN 1210
Query: 178 QQQAQERCQRLREDWE------AGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQ 231
Q+ +++ ++ + +++ + S+E + N R L ++ + A ++ ++Q
Sbjct: 1211 LQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT--LEDQLSEARGKNEEIQ 1268
Query: 232 LAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLT 291
++ +L + SRL+ E L R EEKE +VS+L Q T
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQ------LEEKES------------IVSQLSRSKQAFT 1310
Query: 292 ASLRELQEGLQQEASRPGAPG----SERILLDILEHDWREAQDSRQELCQKLHAVQGEL- 346
EL+ L++E A S R D+L + E Q+ + EL + L E+
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
Query: 347 QWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQ 406
QW + +Q E+L + L + + ++ V A+ +EK ++ R+Q
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK-------TKQRLQ 1423
Query: 407 LQYSQSLIEKDQYRKQVRGLEAER---DELLTT-LTSLEGTKALLEVQLQRAQ 455
+ +++ ++ L+ ++ D++L T E ++A LE L+ ++
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Score = 52.8 bits (125), Expect = 2e-06
Identities = 76/358 (21%), Positives = 149/358 (41%), Gaps = 50/358 (13%)
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWE-- 193
L E + L+EA + L Q + + L + ++ LEQ++ D + + E+ ++LR D E
Sbjct: 993 LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN 1052
Query: 194 ----AGSLEL-----LRLKDENYMIAMRL-------AQLSEEKNSAVLRSRDLQLAVDQL 237
G L+L L L+++ + RL QL + Q + +L
Sbjct: 1053 KRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL 1112
Query: 238 KLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLREL 297
+ ++ LEEE R R + EK++ ++ +SE E +T++ EL
Sbjct: 1113 QARIEELEEEIEAERATRA--------KTEKQRSDYARELEELSERLEEAGGVTSTQIEL 1164
Query: 298 QEGLQQEASRPGAPGSERILLDILEHD------WREAQDSRQELCQKLHAVQGELQWAEE 351
+ + E + E L+H+ ++ DS EL +++ +Q Q E+
Sbjct: 1165 NKKREAEFLKLRRDLEEA----TLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK 1220
Query: 352 LRDQYLQEMEDLRLKHRT-------LQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDR 404
+ ++ E++DL + L+K C + +++ + EEI++ + + R
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280
Query: 405 IQL---QYSQSLIEKD----QYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
+Q + S+ L EK+ Q + + + +EL L K L LQ ++
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338
Score = 49.7 bits (117), Expect = 1e-05
Identities = 63/300 (21%), Positives = 134/300 (44%), Gaps = 37/300 (12%)
Query: 180 QAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKL 239
+ ++ ++E+++ EL + + + + +L L +EKN DLQL V
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKN-------DLQLQVQAESE 897
Query: 240 KVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLV----------SELRAENQR 289
+ EE C L +A+ ++ E+ +++E N +L SEL+ +
Sbjct: 898 NLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 290 LTASLRELQEGLQQEASRPGAPGSERILLD----ILEHDWREAQDSRQELCQKLHAVQGE 345
L +L ++++ ++ E LD L + + Q++ Q+ L A + +
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017
Query: 346 LQWAEELRDQYLQEMEDLRL---KHRTLQKDCDLYKHRMA--TVLAQ-----LEEIEKER 395
+ + + + Q++EDL + + L+ D + K ++ LAQ LE +++
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077
Query: 396 DQAIQSRDRIQLQYSQSLIEKD-----QYRKQVRGLEAERDELLTTLTSLEGTKALLEVQ 450
D+ ++ +D Q QS +E + Q++K+++ L+A +EL + + T+A E Q
Sbjct: 1078 DERLKKKDFEYCQL-QSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136
Score = 43.5 bits (101), Expect = 0.001
Identities = 77/367 (20%), Positives = 154/367 (41%), Gaps = 49/367 (13%)
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAG 195
L+ R + K++ Q E +++ E+E + +++ ++ C L++D +
Sbjct: 899 LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 958
Query: 196 SLELLRLKDENYMIAMRLAQLSEEKN------SAVLRSRDL-----QLAVDQLKL---KV 241
L L +++ E + ++ L+EE + + + R + Q A+D L+ KV
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV 1018
Query: 242 SRLEEECALLRRARGPPPGAEEKEK------EKEKEKEPDNVDLVSE----LRAENQRLT 291
+ L + + L + + E+EK E+ K K ++ L E L + Q+L
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 292 ASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEE 351
L++ Q S+ E+ L + +E Q +EL +++ A + E+
Sbjct: 1079 ERLKKKDFEYCQLQSK---VEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEK 1135
Query: 352 LRDQYLQEMEDL--RLKHR--TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQL 407
R Y +E+E+L RL+ +L K R A L ++E+ Q ++
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK 1195
Query: 408 QYSQSLIE-----------KDQYRKQVRGLEAERDELLTTLTSLEGTKA-------LLEV 449
+++ S+ E K + K+ + E D+L +++ S+ +KA LE
Sbjct: 1196 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED 1255
Query: 450 QLQRAQG 456
QL A+G
Sbjct: 1256 QLSEARG 1262
Score = 42.4 bits (98), Expect = 0.002
Identities = 101/478 (21%), Positives = 190/478 (39%), Gaps = 70/478 (14%)
Query: 21 EAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEE--VLSTYRFPCRVNRT 78
+A + L E IE R RA + + Y R+ + E+ EE V ST + R
Sbjct: 1113 QARIEELEEEIEA--ERATRAKTEKQRSDYARELEELSERLEEAGGVTST-QIELNKKRE 1169
Query: 79 GRLMDILRC--RGKRGYEAFLEALEFYYPEHFTLLTGQ-EPAQRCSMILDEEGPEGLTQF 135
+ + R +EA + AL + + L Q + QR L++E E
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE----- 1224
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERC--QRLREDWE 193
E+ L + +S + + L+ R LE++ + + + Q++ Q+ R E
Sbjct: 1225 FKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE 1284
Query: 194 AGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQ-------LKLKVSRLEE 246
AG EL R +E I ++QLS K + ++ +L+ +++ L +
Sbjct: 1285 AG--ELSRQLEEKESI---VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 247 ECALLRRARGPPPGAEEKEKEKEKEK----------------EPDNVDLVSELRAENQRL 290
+C LLR EE+E + E ++ E D + EL ++L
Sbjct: 1340 DCDLLREQY-----EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1394
Query: 291 TASLRELQEGLQQ--------EASRPGAPGS-ERILLDILE-HDWREAQDSRQELCQKLH 340
L++ +E ++ E ++ G E +++D+ + A D +Q K+
Sbjct: 1395 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVL 1454
Query: 341 AVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKER---DQ 397
A +W + + E+E + R+L + K+ L QLE +++E +Q
Sbjct: 1455 A-----EWKTKCEESQA-ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Query: 398 AIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
I + +++ E ++ RKQ+ E E+ ++ L E E ++ R Q
Sbjct: 1509 EIADLTEQIAENGKTIHELEKSRKQI---ELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Score = 33.5 bits (75), Expect = 1.1
Identities = 50/232 (21%), Positives = 89/232 (38%), Gaps = 22/232 (9%)
Query: 140 VRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLEL 199
V+ L S + +++L+ L+ E +E RD + A+E+ ++ D + EL
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQLQSE---VEDASRDARNAEEKAKKAITDAAMMAEEL 1770
Query: 200 LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPP 259
+ +D + A L K + +DLQ +D E E L+ +
Sbjct: 1771 KKEQDTS-------AHLERMKKNLEQTVKDLQHRLD---------EAEQLALKGGKKQIQ 1814
Query: 260 GAEEKEKEKEKEKEPD---NVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERI 316
E + +E E E E + N + V LR +R+ + +E + ++
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQV 1874
Query: 317 LLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHR 368
+ + EA + K Q EL+ AEE D ++ LR K R
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 61.6 bits (148), Expect = 4e-09
Identities = 77/349 (22%), Positives = 157/349 (44%), Gaps = 53/349 (15%)
Query: 127 EGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQER-C 185
+GPE + L+ ++ RE + L+ +Q+++ + R+ E E L+ L+++ ++++
Sbjct: 456 QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
Query: 186 QRLREDWEAGSLELLR-LKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRL 244
+ +R+ ++ + +L R ++D A+ A+ +K SA++R L+ ++
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAE--RQKMSALVRG---------LQRELEET 564
Query: 245 EEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQE 304
EE G + +K KE + +LR E + + L E E LQ+E
Sbjct: 565 SEET-----------GHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRE 613
Query: 305 ASRPGAPGSERILLDIL-------EHDWREAQDSRQ-----------ELCQKLHAVQGEL 346
+ A + +++L + + +E Q RQ EL ++L ++ E
Sbjct: 614 LEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEA 673
Query: 347 QWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQ 406
EL +Q LQ + L+ L++DC+ + A ++A E E Q R ++
Sbjct: 674 DRGRELEEQNLQLQKTLQ----QLRQDCE--EASKAKMVA-----EAEATVLGQRRAAVE 722
Query: 407 LQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
++ E D++R+++ GLE + E + E +A L +LQR +
Sbjct: 723 TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLE 771
Score = 55.5 bits (132), Expect = 3e-07
Identities = 103/451 (22%), Positives = 179/451 (39%), Gaps = 68/451 (15%)
Query: 9 EAEEEAGAGSGSEAEEDAL---WERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEV 65
+ +E G G EA E L +R+E + +L ALN + Q+EE
Sbjct: 745 QLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNAS--------------QEEEGS 790
Query: 66 LSTYRFPCRVNRTGRLMDILRCRGKRGYE--AFLEALEFYYPEHFTLLTGQEPAQRCSMI 123
L+ + RL + R + G E ALE + L G+ + +
Sbjct: 791 LAAAKRALEA----RLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL 846
Query: 124 LDEEGPEGLTQFLMTEVRRLREARKSQLQREQ-QLQARGRVLEEERAGLEQRLRDQ---- 178
LD L E+ ++ E K LQ+ Q QL+ E A +++ +D
Sbjct: 847 LDRT-----VDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEA 901
Query: 179 -------QQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQ 231
+ Q+ QRLR+ +A E + + ++A RL L +E + D
Sbjct: 902 EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRA 961
Query: 232 LAVDQLKLKVSRLEEEC--------ALLRRARGPPPGAEE------KEKEKEKEKEPDNV 277
+ L+ KVSRLE E L R ++ +E+ ++ E D +
Sbjct: 962 RQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKI 1021
Query: 278 DLVSELRAENQRLTASLRELQEGLQQ-EASRPGAPGSERILLDILEHDWREAQDSRQELC 336
L + + RL +S EG Q+ AS ++L + L+ + RE + Q
Sbjct: 1022 SLERQNKDLKTRLASS-----EGFQKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTN 1075
Query: 337 QKLHAVQGELQWAEELRDQYLQEMED-LRLKHRTLQKDCDLYKHRMATVLAQLEEIEKER 395
+KL EL E Q++ + +D L L+ + L++ D + + +L+ + K+
Sbjct: 1076 RKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEE----IERLDGLRKKA 1131
Query: 396 DQAIQSRDRI--QLQYSQSLIEKDQYRKQVR 424
+ ++ + + QLQ +EKD +RK R
Sbjct: 1132 QREVEEQHEVNEQLQARIKSLEKDSWRKASR 1162
Score = 49.7 bits (117), Expect = 1e-05
Identities = 83/360 (23%), Positives = 151/360 (41%), Gaps = 68/360 (18%)
Query: 139 EVRRLREARKSQ----LQREQQLQA----------RGRVLEEERAGLEQRLRDQQQAQER 184
E++ L+ R+SQ R+++L+ RGR LEE+ L++ L QQ ++
Sbjct: 640 ELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTL---QQLRQD 696
Query: 185 CQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRS-RDLQLAVDQLKLKVSR 243
C+ EA + M+A A + ++ +AV + R+ Q D+ + ++
Sbjct: 697 CE------EASKAK---------MVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILG 741
Query: 244 LEEECALLRRARGPPPGAE-----------EKEKEKEKEKEPDNVDLVSE--LRAENQRL 290
LE++ L+ RG G E E EK++ +E N E L A + L
Sbjct: 742 LEQQ---LKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRAL 798
Query: 291 TASLRELQEGL----QQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGEL 346
A L E Q GL Q++ + A E ++L E ++ ++ L + + + EL
Sbjct: 799 EARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKEL 858
Query: 347 QWAEELRDQYLQ----EMEDLRLKHR----TLQKDCDLYKHRMATVLAQLEEIEKERDQA 398
+ E Q LQ ++ED + K R Q+ + L ++ E +
Sbjct: 859 EKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
Query: 399 IQSRDRIQLQYSQSLIEKDQYRKQVRGLEAE-------RDELLTTLTSLEGTKALLEVQL 451
Q+ Q + + ++K+ ++++GLE E +D+ L LE + LE +L
Sbjct: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL 978
Score = 49.3 bits (116), Expect = 2e-05
Identities = 85/357 (23%), Positives = 159/357 (44%), Gaps = 65/357 (18%)
Query: 142 RLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLR 201
RL EA++ + Q+ Q R LEEE E R + + +E+ + L + + EL +
Sbjct: 801 RLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEK 860
Query: 202 LKDENYMIAMRL-AQLSEEKNSA-------VLRSRDLQLAVDQLKLKVSRLEEECALLRR 253
+ +++ +L AQL + K A +++D ++ +SRL++E LR+
Sbjct: 861 IGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQ 920
Query: 254 ARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQ-EGLQQEASRPGAPG 312
A AE +KE + + E AEN++ + R Q +GL+++ SR
Sbjct: 921 ALQASQ-AERDTARLDKELLAQRLQGL-EQEAENKKRSQDDRARQLKGLEEKVSR----- 973
Query: 313 SERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM---EDLRLKHRT 369
LE + E +++ + L +++ + ++ ++LR + +QE +DL +
Sbjct: 974 --------LETELDEEKNTVELLTDRVNRGRDQV---DQLRTELMQERSARQDLECDKIS 1022
Query: 370 LQKDCDLYKHRMATV---------LAQLE---EIEKERDQAIQSRDRIQLQYSQSLIE-- 415
L++ K R+A+ L+QLE ++ +ER QA + R++ LQ + +E
Sbjct: 1023 LERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQA-EEREKTVLQSTNRKLERK 1081
Query: 416 ------------------KDQYRKQVRGLEAERDELLTTLTSLEG--TKALLEVQLQ 452
KDQ +V+ L+ + DE + L+G KA EV+ Q
Sbjct: 1082 VKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQ 1138
Score = 48.9 bits (115), Expect = 2e-05
Identities = 81/368 (22%), Positives = 154/368 (41%), Gaps = 49/368 (13%)
Query: 130 EGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLR 189
E L + L EV++ ++ SQ+ E+QL+ + + LE+R + QQ+ + Q ++
Sbjct: 369 EELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMK 428
Query: 190 EDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDL----QLAVDQLKLKVSRLE 245
+ G L+ + + +L + + + + +DL +L + L+ K R+E
Sbjct: 429 RLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK-QRVE 487
Query: 246 EECALLRRARGPPPGAEEKEKEKEKEKEPDNV----------------DLVSE---LRAE 286
E+ L R GA KE+ +++E ++V D + L AE
Sbjct: 488 EQLRLRERELTALKGA-LKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE 546
Query: 287 NQRLTASLRELQEGLQQEASRPGAPGSE--------RILLDILEHDWREAQDSRQELCQK 338
Q+++A +R LQ L++ + G S R L E ++ +EL +K
Sbjct: 547 RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEK 606
Query: 339 LHAVQGELQWA----------EELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQL 388
+ +Q EL+ A E L+ + L+ E+L+ Q +HR + QL
Sbjct: 607 IEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQL 666
Query: 389 EEIEKERDQAIQSRDR-IQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALL 447
+ E D+ + ++ +QLQ + + +D + AE + T L +A +
Sbjct: 667 AVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAE-----ATVLGQRRAAV 721
Query: 448 EVQLQRAQ 455
E L+ Q
Sbjct: 722 ETTLRETQ 729
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 61.6 bits (148), Expect = 4e-09
Identities = 79/341 (23%), Positives = 148/341 (43%), Gaps = 41/341 (12%)
Query: 143 LREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRL-----REDWEAGSL 197
+ EAR+S ++ +Q++ + LEEE ++ LR++++ + + L R D+E+
Sbjct: 1597 VEEARQSCQKKLKQMEVQ---LEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1653
Query: 198 ELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGP 257
LK ++A L KNSA + + QLK ++ E CA +AR
Sbjct: 1654 LRKDLKRTKALLADAQLMLDHLKNSAPSKRE-----IAQLKNQLEESEFTCAAAVKARK- 1707
Query: 258 PPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEAS---------RP 308
A E E E + D + L + RL E+Q L+++ +
Sbjct: 1708 ---AMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKA 1764
Query: 309 GAPGSERILLDI--LEHDWREAQDSRQELCQKLHAVQGELQWAEE-LRDQYLQEMEDLRL 365
+ R L I L+ EA +QEL +KL A+Q ++++ E+ + D+ L ++ ++
Sbjct: 1765 AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKI 1824
Query: 366 KHRTLQKDCDLYKHRMATVLA-----QLEEIEKERDQAI-------QSRDRIQLQYSQSL 413
+ + + + + + LA +E++ +ERDQ I + R+Q Q +
Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884
Query: 414 IEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRA 454
E + ++ ++ EL L SLE L+ L+ A
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1925
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/356 (21%), Positives = 151/356 (42%), Gaps = 45/356 (12%)
Query: 141 RRLREARKSQLQREQQLQAR-GRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLEL 199
+RL++ + +L+ EQQ + + R L + +A E+ R QQ +++CQRL + + L L
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHL 1446
Query: 200 LRLKDENYMIAMR-------LAQLSEEKNSAVLRSRDLQLAVDQLKLKV----SRLEEEC 248
+ N+ + + L+Q EE L+ LQ D L + +LEE+
Sbjct: 1447 EGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKD 1506
Query: 249 ALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRP 308
+ E + ++ ++ D L ++++ + + L A +++ +E L ++A
Sbjct: 1507 MDIAGFTQKVVSLEAELQDISSQESKDEASL-AKVKKQLRDLEAKVKDQEEELDEQAGTI 1565
Query: 309 GAPGSERILLDI------------LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQY 356
++ L++ +E E +++RQ +KL ++ +L+ E + +
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 357 LQEMEDLRLK---------------HRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQS 401
L+E +L K + L+KD K +A L+ + ++ A
Sbjct: 1626 LREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHL---KNSAPSK 1682
Query: 402 RDRIQL--QYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
R+ QL Q +S K + +E E ++L + + K LE QL R Q
Sbjct: 1683 REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ 1738
Score = 42.7 bits (99), Expect = 0.002
Identities = 88/375 (23%), Positives = 147/375 (39%), Gaps = 43/375 (11%)
Query: 88 RGKRGYEAFLEALEFY---YPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLR 144
RG R L+A+ Y YP+H E +R ++ + +++ + RR
Sbjct: 1097 RGSR----LLDAMRMYRQGYPDHMVF---SEFRRRFDVLAPHLTKKHGRNYIVVDERRAV 1149
Query: 145 EARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQ-ERCQRLREDWEAGSLELLRLK 203
E L E+ G RAG RL +Q+ Q R L + G L K
Sbjct: 1150 EELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFK 1209
Query: 204 DENYM-IAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAE 262
+A+R Q + +KN V +L L +L EE + R +
Sbjct: 1210 KRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEE-----QIRNKDEEIQ 1264
Query: 263 EKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDI-- 320
+ + EK ++ N ELR + RL + + EL L E + G S+ LLD
Sbjct: 1265 QLRSKLEKAEKERN-----ELRLNSDRLESRISELTSELTDERNT-GESASQ--LLDAET 1316
Query: 321 -----LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQ-EMED------LRLKHR 368
E + +E Q L +++ ++ E+ A +R + E++D RLK+
Sbjct: 1317 AERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYE 1376
Query: 369 TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSR-DRIQLQYSQSLIEKDQYRKQVRGLE 427
++ D K R+ E+E++ + ++ R +Q +S Q +K+ + L
Sbjct: 1377 RAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT 1436
Query: 428 AERDELLTTLTSLEG 442
A EL T LEG
Sbjct: 1437 A---ELQDTKLHLEG 1448
Score = 36.2 bits (82), Expect = 0.16
Identities = 42/173 (24%), Positives = 77/173 (44%), Gaps = 25/173 (14%)
Query: 142 RLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLRE---DWEAGSLE 198
+L EA K + Q+LQ + + L+ + LEQ + D+ + ++RE E +
Sbjct: 1782 QLEEANKEK----QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ 1837
Query: 199 LLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPP 258
+ RL+ + + +L+EE++ + + +L+ ++ +EE L R
Sbjct: 1838 VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR----- 1892
Query: 259 PGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLR-------ELQEGLQQE 304
KE E ++K +DL S L A NQ L A L+ +LQ ++ E
Sbjct: 1893 -----KEAEASRKKHELEMDLES-LEAANQSLQADLKLAFKRIGDLQAAIEDE 1939
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 61.6 bits (148), Expect = 4e-09
Identities = 79/341 (23%), Positives = 148/341 (43%), Gaps = 41/341 (12%)
Query: 143 LREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRL-----REDWEAGSL 197
+ EAR+S ++ +Q++ + LEEE ++ LR++++ + + L R D+E+
Sbjct: 1597 VEEARQSCQKKLKQMEVQ---LEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKR 1653
Query: 198 ELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGP 257
LK ++A L KNSA + + QLK ++ E CA +AR
Sbjct: 1654 LRKDLKRTKALLADAQLMLDHLKNSAPSKRE-----IAQLKNQLEESEFTCAAAVKARK- 1707
Query: 258 PPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEAS---------RP 308
A E E E + D + L + RL E+Q L+++ +
Sbjct: 1708 ---AMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKA 1764
Query: 309 GAPGSERILLDI--LEHDWREAQDSRQELCQKLHAVQGELQWAEE-LRDQYLQEMEDLRL 365
+ R L I L+ EA +QEL +KL A+Q ++++ E+ + D+ L ++ ++
Sbjct: 1765 AVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKI 1824
Query: 366 KHRTLQKDCDLYKHRMATVLA-----QLEEIEKERDQAI-------QSRDRIQLQYSQSL 413
+ + + + + + LA +E++ +ERDQ I + R+Q Q +
Sbjct: 1825 RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTK 1884
Query: 414 IEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRA 454
E + ++ ++ EL L SLE L+ L+ A
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLA 1925
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/356 (21%), Positives = 151/356 (42%), Gaps = 45/356 (12%)
Query: 141 RRLREARKSQLQREQQLQAR-GRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLEL 199
+RL++ + +L+ EQQ + + R L + +A E+ R QQ +++CQRL + + L L
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHL 1446
Query: 200 LRLKDENYMIAMR-------LAQLSEEKNSAVLRSRDLQLAVDQLKLKV----SRLEEEC 248
+ N+ + + L+Q EE L+ LQ D L + +LEE+
Sbjct: 1447 EGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKD 1506
Query: 249 ALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRP 308
+ E + ++ ++ D L ++++ + + L A +++ +E L ++A
Sbjct: 1507 MDIAGFTQKVVSLEAELQDISSQESKDEASL-AKVKKQLRDLEAKVKDQEEELDEQAGTI 1565
Query: 309 GAPGSERILLDI------------LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQY 356
++ L++ +E E +++RQ +KL ++ +L+ E + +
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 357 LQEMEDLRLK---------------HRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQS 401
L+E +L K + L+KD K +A L+ + ++ A
Sbjct: 1626 LREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHL---KNSAPSK 1682
Query: 402 RDRIQL--QYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
R+ QL Q +S K + +E E ++L + + K LE QL R Q
Sbjct: 1683 REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ 1738
Score = 42.7 bits (99), Expect = 0.002
Identities = 88/375 (23%), Positives = 147/375 (39%), Gaps = 43/375 (11%)
Query: 88 RGKRGYEAFLEALEFY---YPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLR 144
RG R L+A+ Y YP+H E +R ++ + +++ + RR
Sbjct: 1097 RGSR----LLDAMRMYRQGYPDHMVF---SEFRRRFDVLAPHLTKKHGRNYIVVDERRAV 1149
Query: 145 EARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQ-ERCQRLREDWEAGSLELLRLK 203
E L E+ G RAG RL +Q+ Q R L + G L K
Sbjct: 1150 EELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFK 1209
Query: 204 DENYM-IAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAE 262
+A+R Q + +KN V +L L +L EE + R +
Sbjct: 1210 KRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEE-----QIRNKDEEIQ 1264
Query: 263 EKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDI-- 320
+ + EK ++ N ELR + RL + + EL L E + G S+ LLD
Sbjct: 1265 QLRSKLEKAEKERN-----ELRLNSDRLESRISELTSELTDERNT-GESASQ--LLDAET 1316
Query: 321 -----LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQ-EMED------LRLKHR 368
E + +E Q L +++ ++ E+ A +R + E++D RLK+
Sbjct: 1317 AERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYE 1376
Query: 369 TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSR-DRIQLQYSQSLIEKDQYRKQVRGLE 427
++ D K R+ E+E++ + ++ R +Q +S Q +K+ + L
Sbjct: 1377 RAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT 1436
Query: 428 AERDELLTTLTSLEG 442
A EL T LEG
Sbjct: 1437 A---ELQDTKLHLEG 1448
Score = 36.2 bits (82), Expect = 0.16
Identities = 42/173 (24%), Positives = 77/173 (44%), Gaps = 25/173 (14%)
Query: 142 RLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLRE---DWEAGSLE 198
+L EA K + Q+LQ + + L+ + LEQ + D+ + ++RE E +
Sbjct: 1782 QLEEANKEK----QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ 1837
Query: 199 LLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPP 258
+ RL+ + + +L+EE++ + + +L+ ++ +EE L R
Sbjct: 1838 VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR----- 1892
Query: 259 PGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLR-------ELQEGLQQE 304
KE E ++K +DL S L A NQ L A L+ +LQ ++ E
Sbjct: 1893 -----KEAEASRKKHELEMDLES-LEAANQSLQADLKLAFKRIGDLQAAIEDE 1939
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 61.2 bits (147), Expect = 5e-09
Identities = 83/375 (22%), Positives = 147/375 (39%), Gaps = 67/375 (17%)
Query: 141 RRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELL 200
R E ++S L RE L+ LEE ++ ++ + Q+LR D LE
Sbjct: 1132 RAKAEKQRSDLSRE--LEEISERLEEAGGATSAQVELNKKREAEFQKLRRD-----LEEA 1184
Query: 201 RLKDENYMIAMR------LAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRA 254
L+ E + A+R +A+L E+ ++ + L+ +LK++ L + +A
Sbjct: 1185 TLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKA 1244
Query: 255 RG---------PPPGAEEKEKEKEKE---------------------KEPDNVD-LVSEL 283
+G +E K KE+E++ ++ D D LVS+L
Sbjct: 1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQL 1304
Query: 284 RAENQRLTASLRELQEGLQQEASRPGAPG----SERILLDILEHDWREAQDSRQELCQKL 339
Q T + EL+ L++E A S R D+L + E Q+ + EL + L
Sbjct: 1305 SRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRAL 1364
Query: 340 HAVQGEL-QWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQ- 397
E+ QW + +Q E+L + L + + + V A+ +EK + +
Sbjct: 1365 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 398 ----------------AIQSRDRIQLQYSQSLIE-KDQYRKQVRGLEAERDELLTTLTSL 440
A + D+ Q + + L E K +Y + LEA + E + T L
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 441 EGTKALLEVQLQRAQ 455
K + E L + +
Sbjct: 1485 FKVKNVYEESLDQLE 1499
Score = 50.8 bits (120), Expect = 6e-06
Identities = 100/480 (20%), Positives = 189/480 (39%), Gaps = 59/480 (12%)
Query: 5 AEAGEAEEEAGAGSGSEAEEDAL-----------WERIEGVRHRLARALNPAKLTPYLRQ 53
A+ + EAG S E+DAL ++IE ++H+L + Q
Sbjct: 1278 AQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQ 1337
Query: 54 -----CRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHF 108
C ++ EQ EEE +++ ++ + R K +A E +
Sbjct: 1338 SSRHDCDLLREQYEEEQEGKAELQRALSKANS--EVAQWRTKYETDAIQRTEELEEAKKK 1395
Query: 109 TLLTGQEP--------AQRCSMILDEEGPEGLTQFLMTEVRRLREA----RKSQLQREQQ 156
QE A+ S+ ++ + + LM +V R A K Q ++
Sbjct: 1396 LAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKV 1455
Query: 157 LQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQL 216
L + EE +A LE ++ + +++ +E +L L+ EN + ++ L
Sbjct: 1456 LSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDL 1515
Query: 217 SE---EKNSAVLRSRDLQLAVDQLKLKV-SRLEEECALLRRARGP---------PPGAEE 263
+E E + ++ V+Q K ++ + LEE A L G +E
Sbjct: 1516 TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1575
Query: 264 KEKEKEKEKEPDNVDLVSELRAENQRLT--ASLRELQEGLQQEASRPGAPGSERILLDIL 321
K EK++E D + E + T A +R + L+ + G L+ +
Sbjct: 1576 DRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGD-------LNEM 1628
Query: 322 EHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381
E A E + QG L+ + D L+ EDL+ + +++ +L + +
Sbjct: 1629 EIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEI 1688
Query: 382 ATVLAQLEEIEKER----DQAIQSRDRIQLQYSQ--SLIE-KDQYRKQVRGLEAERDELL 434
+ A LE+ E+ R + + + +R+QL ++Q SLI K + V L++E +E++
Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748
Score = 50.1 bits (118), Expect = 1e-05
Identities = 75/322 (23%), Positives = 136/322 (42%), Gaps = 46/322 (14%)
Query: 136 LMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAG 195
L E + L+E + L Q + + +L + + LEQ++ D + + E+ ++LR D E
Sbjct: 995 LSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERA 1054
Query: 196 SLEL---LRLKDENYMIAMRLAQLSEEK--------NSAVLRSRDLQLAVDQLKLKVSRL 244
+L L+L E+ M Q +EK ++ + + D Q QL+ K+ L
Sbjct: 1055 KRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKEL 1114
Query: 245 EEECALLRRARGPPPGAE-EKEKEKEKEKEPDNVDLVSELRAENQRL------TASLREL 297
+ AR G E E E+ + E DL EL ++RL T++ EL
Sbjct: 1115 Q--------ARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEL 1166
Query: 298 QEGLQQEASRPGAPGSERILLDILEHD------WREAQDSRQELCQKLHAVQGELQWAEE 351
+ + E + E L+H+ ++ DS EL +++ +Q Q E+
Sbjct: 1167 NKKREAEFQKLRRDLEEA----TLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEK 1222
Query: 352 LRDQYLQEMEDLRLKHR-------TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDR 404
+ + E +DL L+K C + +++ + + EE ++ + R R
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR 1282
Query: 405 IQL---QYSQSLIEKDQYRKQV 423
+Q +YS+ L EKD Q+
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQL 1304
Score = 42.7 bits (99), Expect = 0.002
Identities = 56/281 (19%), Positives = 121/281 (43%), Gaps = 28/281 (9%)
Query: 198 ELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGP 257
E + KDE + +L E+ + + DLQL V ++ EE C L + +
Sbjct: 858 EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQ 917
Query: 258 PPGAEEKEKEKEKEKEPDNVDLV----------SELRAENQRLTASLRELQEGLQQEASR 307
++ E+ +E+E N +L SEL+ + L +L ++++ ++
Sbjct: 918 LEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 977
Query: 308 PGAPGSERILLD----ILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDL 363
E LD L + + Q++ Q+ L A + ++ + + + Q+++DL
Sbjct: 978 VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDL 1037
Query: 364 R---LKHRTLQKDCDLYKHRMATVLAQLEE----IEKERDQAIQSRDRIQLQYSQ--SLI 414
+ + L+ D + K ++ L +E +E ++ Q + ++ + + S S I
Sbjct: 1038 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKI 1097
Query: 415 EKD-----QYRKQVRGLEAERDELLTTLTSLEGTKALLEVQ 450
E + Q +K+++ L+A +EL + + ++A E Q
Sbjct: 1098 EDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138
Score = 42.7 bits (99), Expect = 0.002
Identities = 70/344 (20%), Positives = 141/344 (40%), Gaps = 38/344 (11%)
Query: 142 RLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLR 201
R + K+++Q E +++ EEE + +++ ++ C L++D + L L +
Sbjct: 907 RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 966
Query: 202 LKDENYMIAMRLAQLSEE------------KNSAVLRSRDLQLAVDQLKL---KVSRLEE 246
++ E + ++ L+EE K L+ Q +D L+ KV+ L +
Sbjct: 967 VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH-QQTLDDLQAEEDKVNILTK 1025
Query: 247 ECALLRRARGPPPGAEEKEK------EKEKEKEPDNVDLVSELRAENQRLTASLRELQEG 300
L + G+ E+EK E+ K K ++ L E + + L E E
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEK 1085
Query: 301 LQQEASRPGAPGSERILLDI-LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQE 359
+ E S + + ++I L+ +E Q +EL +++ A + AE+ R +E
Sbjct: 1086 KEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE 1145
Query: 360 MEDL--RLKHR--TLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIE 415
+E++ RL+ +L K R A ++E+ Q ++ +++ S+ E
Sbjct: 1146 LEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAE 1205
Query: 416 -----------KDQYRKQVRGLEAERDELLTTLTSLEGTKALLE 448
K + K+ L+ E D+L + ++ K LE
Sbjct: 1206 LGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249
Score = 39.3 bits (90), Expect = 0.019
Identities = 80/394 (20%), Positives = 152/394 (38%), Gaps = 47/394 (11%)
Query: 93 YEAFLEALEFYYPEHFTLLTGQ-EPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQL 151
+EA + AL + + L Q + QR L++E E L E L ++
Sbjct: 1188 HEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE-----LKMETDDLSSNAEAIS 1242
Query: 152 QREQQLQARGRVLEEERAGLEQRLRDQQQAQE--RCQRLREDWEAGSLELLRLKDENYMI 209
+ + L+ R LE++ + L+ + +QQ+ QR R EAG E R DE +
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAG--EYSRQLDEKDAL 1300
Query: 210 AMRLAQLSEEKNSAVLRSRDLQLAVDQ-------LKLKVSRLEEECALLRRARGPPPGAE 262
++QLS K ++ + +L+ +++ L + +C LLR E
Sbjct: 1301 ---VSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQY-----EE 1352
Query: 263 EKEKEKEKEK----------------EPDNVDLVSELRAENQRLTASLRELQEGLQQEAS 306
E+E + E ++ E D + EL ++L L+E +E ++ +
Sbjct: 1353 EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNA 1412
Query: 307 RPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGEL-----QWAEELRDQYLQEME 361
+ + + L D + C L Q +W ++ + E+E
Sbjct: 1413 KCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQA-ELE 1471
Query: 362 DLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRK 421
+ + R+L + K+ L QLE + +E Q + Q ++ + + K
Sbjct: 1472 ASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEK 1531
Query: 422 QVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQ 455
+ +E E+ E+ L E + E ++ R Q
Sbjct: 1532 IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Score = 35.8 bits (81), Expect = 0.21
Identities = 52/232 (22%), Positives = 97/232 (41%), Gaps = 22/232 (9%)
Query: 140 VRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLEL 199
V+ L S + +++L+ L+ E +E+ +++ + A+E+ ++ D + EL
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQLQSE---VEEVIQESRNAEEKAKKAITDAAMMAEEL 1772
Query: 200 LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVD---QLKLKVSRLEEECALLRRARG 256
+ +D + A L K + +DLQ +D QL LK + + + L R R
Sbjct: 1773 KKEQDTS-------AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQ-KLEARVR- 1823
Query: 257 PPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERI 316
E E E E E++ N + V LR +R+ + +E + +
Sbjct: 1824 ------ELEGEVENEQKR-NAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQA 1876
Query: 317 LLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHR 368
+ + EA++ K +Q EL+ AEE D ++ LR+K R
Sbjct: 1877 KVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSR 1928
Score = 35.0 bits (79), Expect = 0.37
Identities = 74/370 (20%), Positives = 150/370 (40%), Gaps = 47/370 (12%)
Query: 113 GQEPAQRCSMILDEEGPEGLTQFLMTEVRR---LREARKSQLQREQQLQARGRVLEEERA 169
G+ QR + E + T++ ++R L EA+K QR Q+ + + + A
Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 170 GLE---QRLR--------DQQQAQERCQRL--------------REDWEAGSLELLRLKD 204
LE QRL+ D +++ C L ++ +E EL +
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQK 1475
Query: 205 ENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEK 264
E+ ++ L ++ ++ + L+ L+ ++S L E+ A G EK
Sbjct: 1476 ESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIA----EGGKQIHELEK 1531
Query: 265 EKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQ---EASRPGAPGSERILLDIL 321
K++ ++++ + + E A + + +Q L Q E R A E I D L
Sbjct: 1532 IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI--DQL 1589
Query: 322 EHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381
+ + ++ Q + + ++ + L EME ++L H L +R
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME-IQLNHANRLAAESLRNYRN 1648
Query: 382 ATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLE 441
+ L+E + D A++ ++ ++ Q + ++E+ + L+AE +EL TL E
Sbjct: 1649 TQGI--LKETQLHLDDALRGQEDLKEQLA--IVER-----RANLLQAEIEELWATLEQTE 1699
Query: 442 GTKALLEVQL 451
++ + E +L
Sbjct: 1700 RSRKIAEQEL 1709
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 60.8 bits (146), Expect = 6e-09
Identities = 78/328 (23%), Positives = 141/328 (42%), Gaps = 40/328 (12%)
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLK 203
+E + + + + L +R R +E E AGL ++L ++ A+ER R + +A E R +
Sbjct: 1346 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1405
Query: 204 DENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEE 263
+E A L E + A + L + + V RLE R R ++
Sbjct: 1406 EEE---AGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE------RGRRRLQQELDD 1456
Query: 264 KEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGL---QQEASRPGAPGSERILLDI 320
+ E++++ LVS L + ++ L E + + +E R A G ER +
Sbjct: 1457 ATMDLEQQRQ-----LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511
Query: 321 -LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKH 379
L E Q++R+EL ++ A++ EL + L +D+ L++ C + +
Sbjct: 1512 SLTRALEEEQEAREELERQNRALRAEL-------EALLSSKDDVGKSVHELERACRVAEQ 1564
Query: 380 RMATVLAQLEEIEKERDQAIQSRDRIQL-------QYSQSLIEKD--------QYRKQVR 424
+ AQ+ E+E E A ++ R+++ Q+ + L +D Q KQ+R
Sbjct: 1565 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1624
Query: 425 GLEAERDELLTTLTSLEGTKALLEVQLQ 452
E ERDE T + LE +L+
Sbjct: 1625 DAEVERDEERKQRTLAVAARKKLEGELE 1652
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/420 (22%), Positives = 160/420 (38%), Gaps = 115/420 (27%)
Query: 139 EVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLE 198
E+++++E ++ + +LQ R LEEERA L ++LR + + + R A E
Sbjct: 885 ELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQE 944
Query: 199 L------------------LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK 240
L +++ E + + +L + + LQL + K
Sbjct: 945 LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK 1004
Query: 241 VSRLEEECALL----------------RRARGPPPGAEEKEKEKEKEK-----EPDNVDL 279
+ + EE+ LL R A AEE+EK K K E D+
Sbjct: 1005 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1064
Query: 280 VSELRAEN-------------------------------QRLTASLRELQEGLQQEASRP 308
LR E + L A L +E LQ +R
Sbjct: 1065 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA 1124
Query: 309 GAPGSERILL---------------DILEHD---WREAQDSRQELCQKLHAVQGELQ--- 347
G R L + LE + +A+ R++L ++L A++GEL+
Sbjct: 1125 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1184
Query: 348 ----WAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRD 403
+ELR + QE+ +L+ +TL+++ +++ A ++E+ + QA+
Sbjct: 1185 DSTNAQQELRSKREQEVTELK---KTLEEETRIHE-------AAVQELRQRHGQAL---G 1231
Query: 404 RIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL-------EGTKALLEVQLQRAQG 456
+ Q Q+ K + K LEAE EL L+SL E + LE+QLQ QG
Sbjct: 1232 ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQG 1291
Score = 54.3 bits (129), Expect = 6e-07
Identities = 119/503 (23%), Positives = 195/503 (38%), Gaps = 82/503 (16%)
Query: 113 GQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLE 172
G++ ++ LD E E L + ++ + +R E R ++E++LQA E+E
Sbjct: 1074 GRQELEKLKRRLDGESSE-LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARA 1132
Query: 173 QRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAV-------- 224
Q L+ ++AQ +ED E+ + + + + + L L E +
Sbjct: 1133 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1192
Query: 225 LRSRDLQLAVDQLKLKVSRLEEECAL-------LRRARGPPPG--AEEKEKEKEKEKEPD 275
LRS+ Q V +LK LEEE + LR+ G G AE+ E+ + + +
Sbjct: 1193 LRSKREQ-EVTELK---KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWE 1248
Query: 276 NVDL-----VSELRAE--------------NQRLTASLRELQEGLQQEASRPGAPGSERI 316
L VSELRAE +RL L+E+Q G + R A +E++
Sbjct: 1249 KTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ-GRAGDGERARAEAAEKL 1307
Query: 317 L-----LDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQ 371
L+ + EA+ L ++L + + +L A+EL + + L + R ++
Sbjct: 1308 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1367
Query: 372 KDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQ---------SLIEKDQYRKQ 422
+ A + QLEE R++A + Q Q S+ +E + ++
Sbjct: 1368 AEA-------AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1420
Query: 423 VRGLEAER-----DELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTW 477
EAE E T+ LE + L+ +L A L S L
Sbjct: 1421 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA-----TMDLEQQRQLVSTLEK-- 1473
Query: 478 SLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSI---LPFPPSAGSILRR 534
+F L A +AAV+ E EA E+E LS+ L A L R
Sbjct: 1474 KQRKFDQLL----AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1529
Query: 535 QREEDPAPPKRSFSSMSDITGSV 557
Q A + SS D+ SV
Sbjct: 1530 QNRALRAELEALLSSKDDVGKSV 1552
Score = 54.3 bits (129), Expect = 6e-07
Identities = 96/433 (22%), Positives = 163/433 (37%), Gaps = 63/433 (14%)
Query: 4 RAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPA------KLTPYLRQCRVI 57
RA+ E E+E A ++ + + ++ R + + A +L LR V
Sbjct: 1570 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV- 1628
Query: 58 DEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPA 117
E+DEE T R G L ++ G G+E A
Sbjct: 1629 -ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ-------------------GKEEA 1668
Query: 118 QRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRL-- 175
+ + + E L EV R +R+ + ++ + R + LE E L++ L
Sbjct: 1669 VKQLRKMQAQMKE-----LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1723
Query: 176 --RDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLA 233
R ++QAQ+ + ++ G+L + +E + RL QL EE S L
Sbjct: 1724 SDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDR 1783
Query: 234 VDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTAS 293
+L L+V L E L R AE ++ E++ + L E R +
Sbjct: 1784 YRKLLLQVESLTTE---LSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1840
Query: 294 LRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELR 353
+ L+ L Q + ERIL L + + + L + + V+ E + A++LR
Sbjct: 1841 IAALESKLAQAEEQLEQETRERILSGKL------VRRAEKRLKEVVLQVEEERRVADQLR 1894
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSL 413
DQ E +LR+K + QLEE E+E +A R R+Q +
Sbjct: 1895 DQL--EKGNLRVKQ----------------LKRQLEEAEEEASRAQAGRRRLQRELEDVT 1936
Query: 414 IEKDQYRKQVRGL 426
+ ++V L
Sbjct: 1937 ESAESMNREVTTL 1949
Score = 48.1 bits (113), Expect = 4e-05
Identities = 79/354 (22%), Positives = 140/354 (39%), Gaps = 70/354 (19%)
Query: 151 LQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIA 210
++ ++ +A GR E L + L ++Q+A+E +R A LL KD+ +
Sbjct: 1493 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD---VG 1549
Query: 211 MRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALL------------RRARGPP 258
+ +L A + DL+ V +L+ +++ E+ L R +G
Sbjct: 1550 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1609
Query: 259 PGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLR---ELQEGLQQEASRPGAPGSER 315
EE+ ++ K+ V+ E + + A + EL+E Q AS G E
Sbjct: 1610 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS--AGQGKEE 1667
Query: 316 ILLDI------LEHDWREAQDSR----------QELCQKLHAVQGE-LQWAEEL------ 352
+ + ++ WRE +++R +E ++L ++ E L+ EEL
Sbjct: 1668 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1727
Query: 353 -------RDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI 405
RD+ E+ + L + ++ K ++ L QLEE E E +Q
Sbjct: 1728 RRQAQQDRDEMADEVANGNLSKAAILEE----KRQLEGRLGQLEE-ELEEEQ-------- 1774
Query: 406 QLQYSQSLIEKDQYRK---QVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQG 456
S S + D+YRK QV L E + E + LE Q+Q +G
Sbjct: 1775 ----SNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRG 1824
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 60.8 bits (146), Expect = 6e-09
Identities = 78/328 (23%), Positives = 141/328 (42%), Gaps = 40/328 (12%)
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLK 203
+E + + + + L +R R +E E AGL ++L ++ A+ER R + +A E R +
Sbjct: 1338 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1397
Query: 204 DENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEE 263
+E A L E + A + L + + V RLE R R ++
Sbjct: 1398 EEE---AGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE------RGRRRLQQELDD 1448
Query: 264 KEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGL---QQEASRPGAPGSERILLDI 320
+ E++++ LVS L + ++ L E + + +E R A G ER +
Sbjct: 1449 ATMDLEQQRQ-----LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503
Query: 321 -LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKH 379
L E Q++R+EL ++ A++ EL + L +D+ L++ C + +
Sbjct: 1504 SLTRALEEEQEAREELERQNRALRAEL-------EALLSSKDDVGKSVHELERACRVAEQ 1556
Query: 380 RMATVLAQLEEIEKERDQAIQSRDRIQL-------QYSQSLIEKD--------QYRKQVR 424
+ AQ+ E+E E A ++ R+++ Q+ + L +D Q KQ+R
Sbjct: 1557 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1616
Query: 425 GLEAERDELLTTLTSLEGTKALLEVQLQ 452
E ERDE T + LE +L+
Sbjct: 1617 DAEVERDEERKQRTLAVAARKKLEGELE 1644
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/420 (22%), Positives = 160/420 (38%), Gaps = 115/420 (27%)
Query: 139 EVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLE 198
E+++++E ++ + +LQ R LEEERA L ++LR + + + R A E
Sbjct: 877 ELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQE 936
Query: 199 L------------------LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK 240
L +++ E + + +L + + LQL + K
Sbjct: 937 LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK 996
Query: 241 VSRLEEECALL----------------RRARGPPPGAEEKEKEKEKEK-----EPDNVDL 279
+ + EE+ LL R A AEE+EK K K E D+
Sbjct: 997 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1056
Query: 280 VSELRAEN-------------------------------QRLTASLRELQEGLQQEASRP 308
LR E + L A L +E LQ +R
Sbjct: 1057 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA 1116
Query: 309 GAPGSERILL---------------DILEHD---WREAQDSRQELCQKLHAVQGELQ--- 347
G R L + LE + +A+ R++L ++L A++GEL+
Sbjct: 1117 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1176
Query: 348 ----WAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRD 403
+ELR + QE+ +L+ +TL+++ +++ A ++E+ + QA+
Sbjct: 1177 DSTNAQQELRSKREQEVTELK---KTLEEETRIHE-------AAVQELRQRHGQAL---G 1223
Query: 404 RIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL-------EGTKALLEVQLQRAQG 456
+ Q Q+ K + K LEAE EL L+SL E + LE+QLQ QG
Sbjct: 1224 ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQG 1283
Score = 54.3 bits (129), Expect = 6e-07
Identities = 119/503 (23%), Positives = 195/503 (38%), Gaps = 82/503 (16%)
Query: 113 GQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLE 172
G++ ++ LD E E L + ++ + +R E R ++E++LQA E+E
Sbjct: 1066 GRQELEKLKRRLDGESSE-LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARA 1124
Query: 173 QRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAV-------- 224
Q L+ ++AQ +ED E+ + + + + + L L E +
Sbjct: 1125 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1184
Query: 225 LRSRDLQLAVDQLKLKVSRLEEECAL-------LRRARGPPPG--AEEKEKEKEKEKEPD 275
LRS+ Q V +LK LEEE + LR+ G G AE+ E+ + + +
Sbjct: 1185 LRSKREQ-EVTELK---KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWE 1240
Query: 276 NVDL-----VSELRAE--------------NQRLTASLRELQEGLQQEASRPGAPGSERI 316
L VSELRAE +RL L+E+Q G + R A +E++
Sbjct: 1241 KTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ-GRAGDGERARAEAAEKL 1299
Query: 317 L-----LDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQ 371
L+ + EA+ L ++L + + +L A+EL + + L + R ++
Sbjct: 1300 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1359
Query: 372 KDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQ---------SLIEKDQYRKQ 422
+ A + QLEE R++A + Q Q S+ +E + ++
Sbjct: 1360 AEA-------AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1412
Query: 423 VRGLEAER-----DELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTW 477
EAE E T+ LE + L+ +L A L S L
Sbjct: 1413 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA-----TMDLEQQRQLVSTLEK-- 1465
Query: 478 SLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSI---LPFPPSAGSILRR 534
+F L A +AAV+ E EA E+E LS+ L A L R
Sbjct: 1466 KQRKFDQLL----AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1521
Query: 535 QREEDPAPPKRSFSSMSDITGSV 557
Q A + SS D+ SV
Sbjct: 1522 QNRALRAELEALLSSKDDVGKSV 1544
Score = 54.3 bits (129), Expect = 6e-07
Identities = 96/433 (22%), Positives = 163/433 (37%), Gaps = 63/433 (14%)
Query: 4 RAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPA------KLTPYLRQCRVI 57
RA+ E E+E A ++ + + ++ R + + A +L LR V
Sbjct: 1562 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV- 1620
Query: 58 DEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPA 117
E+DEE T R G L ++ G G+E A
Sbjct: 1621 -ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ-------------------GKEEA 1660
Query: 118 QRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRL-- 175
+ + + E L EV R +R+ + ++ + R + LE E L++ L
Sbjct: 1661 VKQLRKMQAQMKE-----LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1715
Query: 176 --RDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLA 233
R ++QAQ+ + ++ G+L + +E + RL QL EE S L
Sbjct: 1716 SDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDR 1775
Query: 234 VDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTAS 293
+L L+V L E L R AE ++ E++ + L E R +
Sbjct: 1776 YRKLLLQVESLTTE---LSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1832
Query: 294 LRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELR 353
+ L+ L Q + ERIL L + + + L + + V+ E + A++LR
Sbjct: 1833 IAALESKLAQAEEQLEQETRERILSGKL------VRRAEKRLKEVVLQVEEERRVADQLR 1886
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSL 413
DQ E +LR+K + QLEE E+E +A R R+Q +
Sbjct: 1887 DQL--EKGNLRVKQ----------------LKRQLEEAEEEASRAQAGRRRLQRELEDVT 1928
Query: 414 IEKDQYRKQVRGL 426
+ ++V L
Sbjct: 1929 ESAESMNREVTTL 1941
Score = 48.1 bits (113), Expect = 4e-05
Identities = 79/354 (22%), Positives = 140/354 (39%), Gaps = 70/354 (19%)
Query: 151 LQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIA 210
++ ++ +A GR E L + L ++Q+A+E +R A LL KD+ +
Sbjct: 1485 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD---VG 1541
Query: 211 MRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALL------------RRARGPP 258
+ +L A + DL+ V +L+ +++ E+ L R +G
Sbjct: 1542 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1601
Query: 259 PGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLR---ELQEGLQQEASRPGAPGSER 315
EE+ ++ K+ V+ E + + A + EL+E Q AS G E
Sbjct: 1602 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS--AGQGKEE 1659
Query: 316 ILLDI------LEHDWREAQDSR----------QELCQKLHAVQGE-LQWAEEL------ 352
+ + ++ WRE +++R +E ++L ++ E L+ EEL
Sbjct: 1660 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1719
Query: 353 -------RDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI 405
RD+ E+ + L + ++ K ++ L QLEE E E +Q
Sbjct: 1720 RRQAQQDRDEMADEVANGNLSKAAILEE----KRQLEGRLGQLEE-ELEEEQ-------- 1766
Query: 406 QLQYSQSLIEKDQYRK---QVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQG 456
S S + D+YRK QV L E + E + LE Q+Q +G
Sbjct: 1767 ----SNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRG 1816
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 60.8 bits (146), Expect = 6e-09
Identities = 78/328 (23%), Positives = 141/328 (42%), Gaps = 40/328 (12%)
Query: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLK 203
+E + + + + L +R R +E E AGL ++L ++ A+ER R + +A E R +
Sbjct: 1379 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQ 1438
Query: 204 DENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEE 263
+E A L E + A + L + + V RLE R R ++
Sbjct: 1439 EEE---AGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE------RGRRRLQQELDD 1489
Query: 264 KEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGL---QQEASRPGAPGSERILLDI 320
+ E++++ LVS L + ++ L E + + +E R A G ER +
Sbjct: 1490 ATMDLEQQRQ-----LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544
Query: 321 -LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKH 379
L E Q++R+EL ++ A++ EL + L +D+ L++ C + +
Sbjct: 1545 SLTRALEEEQEAREELERQNRALRAEL-------EALLSSKDDVGKSVHELERACRVAEQ 1597
Query: 380 RMATVLAQLEEIEKERDQAIQSRDRIQL-------QYSQSLIEKD--------QYRKQVR 424
+ AQ+ E+E E A ++ R+++ Q+ + L +D Q KQ+R
Sbjct: 1598 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1657
Query: 425 GLEAERDELLTTLTSLEGTKALLEVQLQ 452
E ERDE T + LE +L+
Sbjct: 1658 DAEVERDEERKQRTLAVAARKKLEGELE 1685
Score = 57.4 bits (137), Expect = 7e-08
Identities = 95/420 (22%), Positives = 160/420 (38%), Gaps = 115/420 (27%)
Query: 139 EVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLE 198
E+++++E ++ + +LQ R LEEERA L ++LR + + + R A E
Sbjct: 918 ELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQE 977
Query: 199 L------------------LRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK 240
L +++ E + + +L + + LQL + K
Sbjct: 978 LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK 1037
Query: 241 VSRLEEECALL----------------RRARGPPPGAEEKEKEKEKEK-----EPDNVDL 279
+ + EE+ LL R A AEE+EK K K E D+
Sbjct: 1038 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1097
Query: 280 VSELRAEN-------------------------------QRLTASLRELQEGLQQEASRP 308
LR E + L A L +E LQ +R
Sbjct: 1098 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARA 1157
Query: 309 GAPGSERILL---------------DILEHD---WREAQDSRQELCQKLHAVQGELQ--- 347
G R L + LE + +A+ R++L ++L A++GEL+
Sbjct: 1158 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1217
Query: 348 ----WAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRD 403
+ELR + QE+ +L+ +TL+++ +++ A ++E+ + QA+
Sbjct: 1218 DSTNAQQELRSKREQEVTELK---KTLEEETRIHE-------AAVQELRQRHGQAL---G 1264
Query: 404 RIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL-------EGTKALLEVQLQRAQG 456
+ Q Q+ K + K LEAE EL L+SL E + LE+QLQ QG
Sbjct: 1265 ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQG 1324
Score = 54.3 bits (129), Expect = 6e-07
Identities = 119/503 (23%), Positives = 195/503 (38%), Gaps = 82/503 (16%)
Query: 113 GQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLE 172
G++ ++ LD E E L + ++ + +R E R ++E++LQA E+E
Sbjct: 1107 GRQELEKLKRRLDGESSE-LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARA 1165
Query: 173 QRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAV-------- 224
Q L+ ++AQ +ED E+ + + + + + L L E +
Sbjct: 1166 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1225
Query: 225 LRSRDLQLAVDQLKLKVSRLEEECAL-------LRRARGPPPG--AEEKEKEKEKEKEPD 275
LRS+ Q V +LK LEEE + LR+ G G AE+ E+ + + +
Sbjct: 1226 LRSKREQ-EVTELK---KTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWE 1281
Query: 276 NVDL-----VSELRAE--------------NQRLTASLRELQEGLQQEASRPGAPGSERI 316
L VSELRAE +RL L+E+Q G + R A +E++
Sbjct: 1282 KTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQ-GRAGDGERARAEAAEKL 1340
Query: 317 L-----LDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQ 371
L+ + EA+ L ++L + + +L A+EL + + L + R ++
Sbjct: 1341 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1400
Query: 372 KDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQ---------SLIEKDQYRKQ 422
+ A + QLEE R++A + Q Q S+ +E + ++
Sbjct: 1401 AEA-------AGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARR 1453
Query: 423 VRGLEAER-----DELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTW 477
EAE E T+ LE + L+ +L A L S L
Sbjct: 1454 RAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA-----TMDLEQQRQLVSTLEK-- 1506
Query: 478 SLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSI---LPFPPSAGSILRR 534
+F L A +AAV+ E EA E+E LS+ L A L R
Sbjct: 1507 KQRKFDQLL----AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1562
Query: 535 QREEDPAPPKRSFSSMSDITGSV 557
Q A + SS D+ SV
Sbjct: 1563 QNRALRAELEALLSSKDDVGKSV 1585
Score = 54.3 bits (129), Expect = 6e-07
Identities = 96/433 (22%), Positives = 163/433 (37%), Gaps = 63/433 (14%)
Query: 4 RAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPA------KLTPYLRQCRVI 57
RA+ E E+E A ++ + + ++ R + + A +L LR V
Sbjct: 1603 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV- 1661
Query: 58 DEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPA 117
E+DEE T R G L ++ G G+E A
Sbjct: 1662 -ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ-------------------GKEEA 1701
Query: 118 QRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRL-- 175
+ + + E L EV R +R+ + ++ + R + LE E L++ L
Sbjct: 1702 VKQLRKMQAQMKE-----LWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1756
Query: 176 --RDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLA 233
R ++QAQ+ + ++ G+L + +E + RL QL EE S L
Sbjct: 1757 SDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDR 1816
Query: 234 VDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTAS 293
+L L+V L E L R AE ++ E++ + L E R +
Sbjct: 1817 YRKLLLQVESLTTE---LSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT 1873
Query: 294 LRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELR 353
+ L+ L Q + ERIL L + + + L + + V+ E + A++LR
Sbjct: 1874 IAALESKLAQAEEQLEQETRERILSGKL------VRRAEKRLKEVVLQVEEERRVADQLR 1927
Query: 354 DQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSL 413
DQ E +LR+K + QLEE E+E +A R R+Q +
Sbjct: 1928 DQL--EKGNLRVKQ----------------LKRQLEEAEEEASRAQAGRRRLQRELEDVT 1969
Query: 414 IEKDQYRKQVRGL 426
+ ++V L
Sbjct: 1970 ESAESMNREVTTL 1982
Score = 48.1 bits (113), Expect = 4e-05
Identities = 79/354 (22%), Positives = 140/354 (39%), Gaps = 70/354 (19%)
Query: 151 LQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIA 210
++ ++ +A GR E L + L ++Q+A+E +R A LL KD+ +
Sbjct: 1526 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD---VG 1582
Query: 211 MRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALL------------RRARGPP 258
+ +L A + DL+ V +L+ +++ E+ L R +G
Sbjct: 1583 KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD 1642
Query: 259 PGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLR---ELQEGLQQEASRPGAPGSER 315
EE+ ++ K+ V+ E + + A + EL+E Q AS G E
Sbjct: 1643 EAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS--AGQGKEE 1700
Query: 316 ILLDI------LEHDWREAQDSR----------QELCQKLHAVQGE-LQWAEEL------ 352
+ + ++ WRE +++R +E ++L ++ E L+ EEL
Sbjct: 1701 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1760
Query: 353 -------RDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRI 405
RD+ E+ + L + ++ K ++ L QLEE E E +Q
Sbjct: 1761 RRQAQQDRDEMADEVANGNLSKAAILEE----KRQLEGRLGQLEE-ELEEEQ-------- 1807
Query: 406 QLQYSQSLIEKDQYRK---QVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQG 456
S S + D+YRK QV L E + E + LE Q+Q +G
Sbjct: 1808 ----SNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRG 1857
>gi|50083293 coiled-coil domain containing 123 [Homo sapiens]
Length = 783
Score = 60.8 bits (146), Expect = 6e-09
Identities = 89/395 (22%), Positives = 171/395 (43%), Gaps = 73/395 (18%)
Query: 133 TQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDW 192
T+ + L+E Q L +++ L+ +L+ ++ + ++L+E
Sbjct: 233 TEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEK---RKLKEAE 289
Query: 193 EAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLR 252
+A S E+ A L L ++ V + L++ V +L +++SR + + L
Sbjct: 290 KASSQEVA---------APELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLS 340
Query: 253 R----------ARGP-PPGAEEKE---------KEKEKEKEPDNVDLVSELRAENQRLTA 292
+ ++GP PP + + ++ KEK+ N L E+R R+
Sbjct: 341 KEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQE 400
Query: 293 SLRELQEGLQQEASRPGAPGSE----------------RILLDILEHDWREAQDSRQELC 336
++E +E L QE ++ A SE ++LL+ LE R+A+DS QE
Sbjct: 401 VVKENEE-LHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERL 459
Query: 337 QKLHAVQGELQWAE--------ELRDQYLQEMEDLRLKHRTLQKDCD------LYKHRMA 382
Q++ + +L E EL + +++E LR K + L+ D ++K +
Sbjct: 460 QEVSKLTKQLMLLEAKTHGQEKELAENR-EQLEILRAKCQELKTHSDGKIAVEVHKSIVN 518
Query: 383 TVLAQLE-EIEKER---DQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLT 438
+ +QL+ E EKER ++ ++ +Q Q L+EK+ +Q + LEAE +
Sbjct: 519 ELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINR 578
Query: 439 SLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNL 473
+ +L+ Q+++A G S+H +NL
Sbjct: 579 KSQKKIEVLKKQVEKAMGNE-----MSAHQYLANL 608
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
Length = 1293
Score = 60.5 bits (145), Expect = 8e-09
Identities = 68/319 (21%), Positives = 145/319 (45%), Gaps = 30/319 (9%)
Query: 137 MTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGS 196
+ ++++L +A+ ++L++E++ EEE ++ LR QQ+ R Q+ E
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 197 LELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARG 256
EL R K E A+ R R+ ++A+ + + + R ++E AL R
Sbjct: 777 EELARRKQE----------------EALRRQREQEIALRRQREEEERQQQEEALRRLEE- 819
Query: 257 PPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERI 316
EE+E+ K++E + ++ E + L E + +++EA+R ER
Sbjct: 820 --RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK 877
Query: 317 LLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDL 376
++ +E RQ+ + L +Q ++ + Q L +M+ Q +
Sbjct: 878 RKELEVQRQKELMRQRQQQQEALRRLQ------QQQQQQQLAQMKLPSSSTWGQQSNTTA 931
Query: 377 YKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTT 436
+ + LA+++++E+ER++ ++ R Q + +++ Q ++Q + L + +
Sbjct: 932 CQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK-LSGWGNVSKPS 990
Query: 437 LTSLEGTKALLEVQLQRAQ 455
T TK+LLE+Q + A+
Sbjct: 991 GT----TKSLLEIQQEEAR 1005
Score = 38.5 bits (88), Expect = 0.033
Identities = 48/221 (21%), Positives = 98/221 (44%), Gaps = 34/221 (15%)
Query: 124 LDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRV------LEEERAGLEQRLRD 177
L+E E + E+ R +E ++ RE++ +A+ R+ +EEE A L +
Sbjct: 817 LEERRREEEERRKQEELLRKQEEEAAKWAREEE-EAQRRLEENRLRMEEEAARLRHEEEE 875
Query: 178 QQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQL 237
+++ + QR + EL+R + + RL Q +++ A ++ Q
Sbjct: 876 RKRKELEVQRQK--------ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 927
Query: 238 KLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLREL 297
+ + +L AE ++ E+E+E++ L E R + + L +L++
Sbjct: 928 NTTACQSQATLSL----------AEIQKLEEERERQ-----LREEQRRQQRELMKALQQQ 972
Query: 298 QEGLQQEASRPG----APGSERILLDILEHDWREAQDSRQE 334
Q+ QQ+ S G G+ + LL+I + + R+ Q +Q+
Sbjct: 973 QQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQ 1013
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 60.5 bits (145), Expect = 8e-09
Identities = 68/319 (21%), Positives = 145/319 (45%), Gaps = 30/319 (9%)
Query: 137 MTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGS 196
+ ++++L +A+ ++L++E++ EEE ++ LR QQ+ R Q+ E
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 197 LELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARG 256
EL R K E A+ R R+ ++A+ + + + R ++E AL R
Sbjct: 804 EELARRKQE----------------EALRRQREQEIALRRQREEEERQQQEEALRRLEE- 846
Query: 257 PPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERI 316
EE+E+ K++E + ++ E + L E + +++EA+R ER
Sbjct: 847 --RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK 904
Query: 317 LLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDL 376
++ +E RQ+ + L +Q ++ + Q L +M+ Q +
Sbjct: 905 RKELEVQRQKELMRQRQQQQEALRRLQ------QQQQQQQLAQMKLPSSSTWGQQSNTTA 958
Query: 377 YKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTT 436
+ + LA+++++E+ER++ ++ R Q + +++ Q ++Q + L + +
Sbjct: 959 CQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQK-LSGWGNVSKPS 1017
Query: 437 LTSLEGTKALLEVQLQRAQ 455
T TK+LLE+Q + A+
Sbjct: 1018 GT----TKSLLEIQQEEAR 1032
Score = 38.5 bits (88), Expect = 0.033
Identities = 48/221 (21%), Positives = 98/221 (44%), Gaps = 34/221 (15%)
Query: 124 LDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRV------LEEERAGLEQRLRD 177
L+E E + E+ R +E ++ RE++ +A+ R+ +EEE A L +
Sbjct: 844 LEERRREEEERRKQEELLRKQEEEAAKWAREEE-EAQRRLEENRLRMEEEAARLRHEEEE 902
Query: 178 QQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQL 237
+++ + QR + EL+R + + RL Q +++ A ++ Q
Sbjct: 903 RKRKELEVQRQK--------ELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 954
Query: 238 KLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLREL 297
+ + +L AE ++ E+E+E++ L E R + + L +L++
Sbjct: 955 NTTACQSQATLSL----------AEIQKLEEERERQ-----LREEQRRQQRELMKALQQQ 999
Query: 298 QEGLQQEASRPG----APGSERILLDILEHDWREAQDSRQE 334
Q+ QQ+ S G G+ + LL+I + + R+ Q +Q+
Sbjct: 1000 QQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQ 1040
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,248,534
Number of Sequences: 37866
Number of extensions: 2396512
Number of successful extensions: 19542
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 200
Number of HSP's successfully gapped in prelim test: 824
Number of HSP's that attempted gapping in prelim test: 13582
Number of HSP's gapped (non-prelim): 4055
length of query: 1032
length of database: 18,247,518
effective HSP length: 112
effective length of query: 920
effective length of database: 14,006,526
effective search space: 12886003920
effective search space used: 12886003920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.