Search of human proteins with 51093859

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51093859 calcium channel, voltage-dependent, T type, alpha
1I subunit isoform b [Homo sapiens]
         (2188 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...  4452   0.0  
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...  4434   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...  1607   0.0  
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...  1599   0.0  
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...  1507   0.0  
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i...  1503   0.0  
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...  1490   0.0  
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...  1489   0.0  
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...  1476   0.0  
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...  1474   0.0  
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...  1471   0.0  
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...  1469   0.0  
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...  1461   0.0  
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...  1461   0.0  
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i...  1457   0.0  
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...  1456   0.0  
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...  1448   0.0  
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...  1444   0.0  
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i...   818   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...   422   e-117
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...   354   6e-97
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...   343   8e-94
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...   343   8e-94
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...   343   8e-94
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...   342   2e-93
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...   338   4e-92
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...   338   4e-92
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...   338   4e-92
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1...   337   8e-92
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1...   337   8e-92

>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score = 4452 bits (11548), Expect = 0.0
 Identities = 2188/2188 (100%), Positives = 2188/2188 (100%)

Query: 1    MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60
            MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
Sbjct: 1    MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60

Query: 61   CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120
            CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
Sbjct: 61   CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120

Query: 121  FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180
            FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
Sbjct: 121  FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180

Query: 181  RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240
            RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
Sbjct: 181  RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240

Query: 241  LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300
            LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
Sbjct: 241  LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300

Query: 301  YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360
            YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
Sbjct: 301  YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360

Query: 361  EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420
            EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
Sbjct: 361  EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420

Query: 421  SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480
            SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
Sbjct: 421  SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480

Query: 481  AKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQE 540
            AKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQE
Sbjct: 481  AKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQE 540

Query: 541  GSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRG 600
            GSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRG
Sbjct: 541  GSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRG 600

Query: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
            IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG
Sbjct: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660

Query: 661  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVL 720
            LFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVL
Sbjct: 661  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVL 720

Query: 721  MKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVF 780
            MKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVF
Sbjct: 721  MKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVF 780

Query: 781  QILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSY 840
            QILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSY
Sbjct: 781  QILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSY 840

Query: 841  SDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPR 900
            SDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPR
Sbjct: 841  SDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPR 900

Query: 901  LSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLK 960
            LSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLK
Sbjct: 901  LSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLK 960

Query: 961  HKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRR 1020
            HKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRR
Sbjct: 961  HKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRR 1020

Query: 1021 TLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDR 1080
            TLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDR
Sbjct: 1021 TLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDR 1080

Query: 1081 GEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV 1140
            GEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV
Sbjct: 1081 GEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV 1140

Query: 1141 VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY 1200
            VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY
Sbjct: 1141 VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY 1200

Query: 1201 LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1260
            LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV
Sbjct: 1201 LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1260

Query: 1261 VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYR 1320
            VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYR
Sbjct: 1261 VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYR 1320

Query: 1321 WVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFL 1380
            WVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFL
Sbjct: 1321 WVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFL 1380

Query: 1381 LIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCH 1440
            LIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCH
Sbjct: 1381 LIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCH 1440

Query: 1441 TRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV 1500
            TRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV
Sbjct: 1441 TRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV 1500

Query: 1501 LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARV 1560
            LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARV
Sbjct: 1501 LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARV 1560

Query: 1561 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGM 1620
            LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGM
Sbjct: 1561 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGM 1620

Query: 1621 SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1680
            SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL
Sbjct: 1621 SRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1680

Query: 1681 TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRG 1740
            TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRG
Sbjct: 1681 TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRG 1740

Query: 1741 PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSP 1800
            PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSP
Sbjct: 1741 PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSP 1800

Query: 1801 AGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPE 1860
            AGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPE
Sbjct: 1801 AGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPE 1860

Query: 1861 PMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASS 1920
            PMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASS
Sbjct: 1861 PMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASS 1920

Query: 1921 PLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDT 1980
            PLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDT
Sbjct: 1921 PLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDT 1980

Query: 1981 SLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLF 2040
            SLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLF
Sbjct: 1981 SLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLF 2040

Query: 2041 SLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSL 2100
            SLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSL
Sbjct: 2041 SLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSL 2100

Query: 2101 FCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSKDPPGRAPLP 2160
            FCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSKDPPGRAPLP
Sbjct: 2101 FCPPPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPSWAADRSKDPPGRAPLP 2160

Query: 2161 MGLGPLAPPPQPLPGELEPGDAASKRKR 2188
            MGLGPLAPPPQPLPGELEPGDAASKRKR
Sbjct: 2161 MGLGPLAPPPQPLPGELEPGDAASKRKR 2188


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score = 4434 bits (11499), Expect = 0.0
 Identities = 2187/2223 (98%), Positives = 2188/2223 (98%), Gaps = 35/2223 (1%)

Query: 1    MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60
            MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
Sbjct: 1    MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60

Query: 61   CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120
            CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
Sbjct: 61   CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120

Query: 121  FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180
            FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
Sbjct: 121  FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180

Query: 181  RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240
            RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
Sbjct: 181  RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240

Query: 241  LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300
            LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
Sbjct: 241  LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300

Query: 301  YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360
            YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
Sbjct: 301  YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360

Query: 361  EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420
            EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
Sbjct: 361  EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420

Query: 421  SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480
            SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
Sbjct: 421  SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480

Query: 481  AKEPRHY-----------------------------------QLCPQHSPLDATPHTLVQ 505
            AKEPRHY                                   +LCPQHSPLDATPHTLVQ
Sbjct: 481  AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ 540

Query: 506  PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 565
            PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
Sbjct: 541  PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 600

Query: 566  ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE 625
            ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
Sbjct: 601  ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE 660

Query: 626  HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV 685
            HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
Sbjct: 661  HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV 720

Query: 686  GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG 745
            GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
Sbjct: 721  GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG 780

Query: 746  MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL 805
            MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
Sbjct: 781  MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL 840

Query: 806  YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD 865
            YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
Sbjct: 841  YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD 900

Query: 866  PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM 925
            PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
Sbjct: 901  PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM 960

Query: 926  SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV 985
            SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
Sbjct: 961  SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV 1020

Query: 986  AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA 1045
            AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
Sbjct: 1021 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA 1080

Query: 1046 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD 1105
            AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
Sbjct: 1081 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD 1140

Query: 1106 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE 1165
            WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
Sbjct: 1141 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE 1200

Query: 1166 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA 1225
            RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
Sbjct: 1201 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA 1260

Query: 1226 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF 1285
            SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
Sbjct: 1261 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF 1320

Query: 1286 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD 1345
            GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
Sbjct: 1321 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD 1380

Query: 1346 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1405
            GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
Sbjct: 1381 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1440

Query: 1406 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1465
            QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
Sbjct: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500

Query: 1466 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1525
            VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
Sbjct: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560

Query: 1526 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1585
            LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
Sbjct: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620

Query: 1586 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 1645
            NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
Sbjct: 1621 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 1680

Query: 1646 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA 1705
            NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
Sbjct: 1681 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA 1740

Query: 1706 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN 1765
            QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
Sbjct: 1741 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN 1800

Query: 1766 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS 1825
            LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
Sbjct: 1801 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS 1860

Query: 1826 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN 1885
            DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
Sbjct: 1861 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN 1920

Query: 1886 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1945
            FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
Sbjct: 1921 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1980

Query: 1946 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD 2005
            GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
Sbjct: 1981 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD 2040

Query: 2006 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH 2065
            SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
Sbjct: 2041 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH 2100

Query: 2066 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA 2125
            DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
Sbjct: 2101 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA 2160

Query: 2126 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK 2185
            APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
Sbjct: 2161 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK 2220

Query: 2186 RKR 2188
            RKR
Sbjct: 2221 RKR 2223


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 1607 bits (4161), Expect = 0.0
 Identities = 922/1624 (56%), Positives = 1079/1624 (66%), Gaps = 141/1624 (8%)

Query: 467  LGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDG 526
            L   +P P +  PH          P H    + P  L  P   TL  +  SCP C     
Sbjct: 649  LSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALE 708

Query: 527  RRPSGLGSTDSGQEGSGSGSSAGGEDEADGDG-------ARSSEDGASSELGKEEEEEEQ 579
                 L  ++SG +  G G     +D   GD          +   G      +   ++  
Sbjct: 709  DPEGELSGSESG-DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRA 767

Query: 580  ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 639
            A G     G +W     KLR IVDSKYF+RGIMMAILVNT+SMG+E+HEQPEELTN LEI
Sbjct: 768  APGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEI 827

Query: 640  CNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFR 699
             N+VFTSMFALEM+LKL A G   Y+RNPYNIFD IIV+IS+WEIVGQADGGLSVLRTFR
Sbjct: 828  SNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFR 887

Query: 700  LLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDT 759
            LLRVLKLVRF+PALRRQLVVL+KTMDNVATFC LLMLFIFIFSILGMH+FGCKFSL+TDT
Sbjct: 888  LLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDT 947

Query: 760  GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLF 819
            GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS WA+LYFVALMTFGNYVLF
Sbjct: 948  GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF 1007

Query: 820  NLLVAILVEGFQAEGDANRSYSDEDQSSSNIEE-FDKLQEGLDSSGDPKLCPIPMTPNGH 878
            NLLVAILVEGFQAEGDANRS +DED++S + EE F KL+E    + + K+C + +TPNGH
Sbjct: 1008 NLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLREL--QTTELKMCSLAVTPNGH 1065

Query: 879  LDPSLPLGGHLGPAGAAGPAPRLSLQP--DPMLVALGSRKSSVMSLGRMSYDQRSLSSSR 936
            L+    L   L    AA P P     P  D       SR+ S  S      DQ+  +S R
Sbjct: 1066 LEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLR 1125

Query: 937  SSYYGPWGRSAAWASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEG 990
            SS   PWG S AW+SRRSSW+SL      K +    E ESLLS E  G     +  A++G
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGST---DDEAEDG 1182

Query: 991  PPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAA 1050
              RAAP           GP    R    RR  SLD                 PR    AA
Sbjct: 1183 --RAAP-----------GP----RATPLRRAESLD-----------------PRPLRPAA 1208

Query: 1051 GPAPGHEDCNGRMPSIAKDVFTKMGD-RGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEV 1109
             P     D +G++ ++  D F ++   R D  E +++ + + C R+ K+++ YKP WC  
Sbjct: 1209 LPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRS 1268

Query: 1110 REDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFL 1169
            RE W++YLFSP+NRFRV CQ +I HK+FD+VVL FIFLNC+TIALERP I+ GSTER+FL
Sbjct: 1269 REAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFL 1328

Query: 1170 TVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGG 1229
            +VSNYIFTAIFV EM +KVV+LGL  GE AYL+SSWN+LDG LV VS++DIVV++ASAGG
Sbjct: 1329 SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGG 1388

Query: 1230 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILG 1289
            AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL+PIGNIVLICCAFFIIFGILG
Sbjct: 1389 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILG 1448

Query: 1290 VQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVN 1349
            VQLFKGKFY+C G DTRNI+ ++ C AA+YRWV  KYNFDNLGQALMSLFVL+SKDGWVN
Sbjct: 1449 VQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVN 1508

Query: 1350 IMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1409
            IMY+GLDAV VDQQPV NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE
Sbjct: 1509 IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1568

Query: 1410 EARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTM 1469
            EARRREEKRLRRLE++RRKAQR PYYA Y  TR  IHS+CTSHYLD+FITFIIC+NV+TM
Sbjct: 1569 EARRREEKRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITM 1628

Query: 1470 SLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVM 1529
            S+EHYNQP SL+ ALKYCNY+FT VFV EA LKLVAFG RRFFKDRWNQLDLAIVLLS+M
Sbjct: 1629 SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM 1688

Query: 1530 GITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1589
            GITLEEIE++AALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL
Sbjct: 1689 GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1748

Query: 1590 LFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM 1649
            LFMLLFFIYAALGVELFG+L C+++NPCEG+SRHATF NFGMAFLTLF+VSTGDNWNGIM
Sbjct: 1749 LFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIM 1808

Query: 1650 KDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDA 1709
            KDTLR+C+ +++ CLS L  +SP+YFV+FVL AQFVL+NVVVAVLMKHL++SNKEA+EDA
Sbjct: 1809 KDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDA 1868

Query: 1710 EMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLD 1769
            E+DAE+ELEMA G G   R+    P  P   PG                          D
Sbjct: 1869 ELDAEIELEMAQGPGSARRVDADRPPLPQESPGAR------------------------D 1904

Query: 1770 SVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSS 1829
            + +L+ +      +  + N S     +   P       H +  +Q  E E +   +    
Sbjct: 1905 APNLVARKVSVSRMLSLPNDS-----YMFRPVVPASAPHPR-PLQEVEMETYGAGTP--- 1955

Query: 1830 SILLGDDLSLEDPTACPPGRKDSKGELDPP----EPMRVGDLGECFFPLSSTAVSPDPEN 1885
               LG   S+  P A      +S   L  P     P R G+      P   TA SP    
Sbjct: 1956 ---LGSVASVHSPPA------ESCASLQIPLAVSSPARSGEPLHALSP-RGTARSPSLSR 2005

Query: 1886 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1945
             LC  E +  + +    K DS +    P  P   +P+ P+                   T
Sbjct: 2006 LLCRQEAVHTDSLEG--KIDSPRDTLDPAEPGEKTPVRPV-------------------T 2044

Query: 1946 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDS----- 2000
              G+L         +  RSPR      R+ T     + + P++  G      + +     
Sbjct: 2045 QGGSLQ--------SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVS 2096

Query: 2001 -LTLSDSPRRALGPP-APAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQ-RSHSSGGS 2057
             +T S  P +    P  P   P AG     RR  S+  +G     G    Q R  +  GS
Sbjct: 2097 HITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGS 2156

Query: 2058 TSPG 2061
              PG
Sbjct: 2157 GEPG 2160



 Score =  624 bits (1608), Expect = e-178
 Identities = 320/504 (63%), Positives = 371/504 (73%), Gaps = 18/504 (3%)

Query: 7   PPSSSAAAPAAEPGVTTEQPGPRS-----------PPSSPPGLEEPLD-GADPH--VPHP 52
           P  +    PAA  G + E PG               PS  P  E   + GAD    VP+P
Sbjct: 14  PLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYP 73

Query: 53  DLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRC 112
            LA   FFCL QTT PR+WC+++VCNPWFE VSMLVI+LNCVTLGM++PC+D++C S+RC
Sbjct: 74  ALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133

Query: 113 KILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNI 172
            IL+ FD FIF FFA+EMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  N+
Sbjct: 134 NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV 193

Query: 173 NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
           +LSAIRTVRVLRPL+AINRVPSMRILV LLLDTLPMLGNVLLLCFFVFFIFGI+GVQLWA
Sbjct: 194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253

Query: 233 GLLRNRCFLEENFTIQGDVA-LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGR 291
           GLLRNRCFL+  F    ++  L PYYQ EE +E PFICS   DNG+  C  IP  +E   
Sbjct: 254 GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRM 313

Query: 292 ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIF 351
            C L   + Y          A   C+NWN+YYNVCR+G +NPH GAINFDNIGYAWI IF
Sbjct: 314 PCTLGW-EAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIF 372

Query: 352 QVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRL 411
           QVITLEGWV+IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE +L
Sbjct: 373 QVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 432

Query: 412 MLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR-RQALGP 469
           M EQR R+LS+ ST+AS++EPG CYEE+ +YV HI RK KRR+L LY   QSR R+ + P
Sbjct: 433 MREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDP 492

Query: 470 EAPAPAKPGPHAKEPRHYQLCPQH 493
            A     PG   +    +     H
Sbjct: 493 SAVQGQGPGHRQRRAGRHTASVHH 516



 Score =  116 bits (290), Expect = 3e-25
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 10/192 (5%)

Query: 1123 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTERIFLTVSNYIFTAIF 1180
            R R  C  ++ +  F++V +  I LNC+T+ + RP   +E GS     L   +    A F
Sbjct: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147

Query: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240
              EM +K+V+LGL FG++ YL  +WN LD F+V   +++      S  G  +   L  +R
Sbjct: 148  AVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEY-----SLDGHNVS--LSAIR 199

Query: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300
             +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G   + 
Sbjct: 200  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259

Query: 1301 LGVDTRNITNRS 1312
              +D+  + N +
Sbjct: 260  CFLDSAFVRNNN 271



 Score =  109 bits (272), Expect = 3e-23
 Identities = 60/170 (35%), Positives = 100/170 (58%), Gaps = 10/170 (5%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131
            C K++ +  F+ V ++ I LNCVT+ + +P  D+D  S     L V +      F  EM+
Sbjct: 1287 CQKVITHKMFDHVVLVFIFLNCVTIALERP--DIDPGSTERVFLSVSNYIFTAIFVAEMM 1344

Query: 132  LKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRVL 183
            +K+VALG+  G+  YL  +WN LD  +V+  +V+  + + +         L  +R +R L
Sbjct: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404

Query: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            RPL+ I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G
Sbjct: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 29/252 (11%)

Query: 525 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS--------------SEL 570
           +G R +       G    G  +  G   E+ G   R +E G+               +EL
Sbjct: 3   EGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAEL 62

Query: 571 GKEEEEE---EQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI--- 624
           G +EE+          V+ C       R+    +V + +F    M+ I++N V++G+   
Sbjct: 63  GADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP 122

Query: 625 -EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFD---YLRNPYNIFDSIIVIIS 680
            E  E   E  NILE  +    + FA+EM++K+ A GLF    YL + +N  D  IV+  
Sbjct: 123 CEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAG 182

Query: 681 IWEIVGQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLF 737
           + E     DG    LS +RT R+LR L+ +  +P++R  + +L+ T+  +    +L    
Sbjct: 183 MMEY--SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240

Query: 738 IFIFSILGMHIF 749
            FIF I+G+ ++
Sbjct: 241 FFIFGIVGVQLW 252



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 51/180 (28%), Positives = 88/180 (48%), Gaps = 21/180 (11%)

Query: 67   SPRNWCIKMVCNP-WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF 125
            SP    I  +C   + +     +I +N +T+ M +  +    L +  K        +F+F
Sbjct: 1598 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSM-EHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 126  FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA--------- 176
               E  LK+VA   FG + +  D WN+LD  IV+  ++   + L+ I +SA         
Sbjct: 1657 ---EAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINPTII 1708

Query: 177  --IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
              +R +R+ R LK +     MR L++ ++  LP +GN+ LL   +FFI+  +GV+L+  L
Sbjct: 1709 RIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRL 1768



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 46/161 (28%), Positives = 82/161 (50%), Gaps = 20/161 (12%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETALKYCNYM------FTTVFVLEAVLKLVAFGL---RRF 1511
            +I LN VT+ +  +     +E   + CN +          F +E V+K+VA GL   + +
Sbjct: 109  VIMLNCVTLGM--FRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCY 166

Query: 1512 FKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1571
              D WN+LD  IV+  +M  +L+   ++         +  +R +R+ R L+ +     MR
Sbjct: 167  LGDTWNRLDFFIVVAGMMEYSLDGHNVS---------LSAIRTVRVLRPLRAINRVPSMR 217

Query: 1572 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
             L+  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 218  ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 45/161 (27%), Positives = 84/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           ++V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQP-------EELTNALEISNIVFTSMFALEM 840

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++A G  G   Y+ + +N  D  IV+  + E  +   +  LS +RT R+LR LK + 
Sbjct: 841 LLKLLACGPLG---YIRNPYNIFDGIIVVISVWEI-VGQADGGLSVLRTFRLLRVLKLVR 896

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P++R  + +L+ T+  +     L     FIF I+G+ L+
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 31/96 (32%), Positives = 56/96 (58%), Gaps = 14/96 (14%)

Query: 1327 NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFF 1386
            NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  +YFI  +++ SFF
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIVGSFF 409

Query: 1387 VLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
            ++N+ + V+   F + +Q     E++   E+R R L
Sbjct: 410  MINLCLVVIATQFSETKQ----RESQLMREQRARHL 441



 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 33/103 (32%), Positives = 55/103 (53%), Gaps = 12/103 (11%)

Query: 326  CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNF 375
            CR       +   NFDN+G A + +F + + +GWV IMY  +DA          H+ +  
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532

Query: 376  IYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQR 418
            +YFI  +++ SFF++N+ + V+   F   K R+H+   E R+R
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRR 1573



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 2/74 (2%)

Query: 328  TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSF 387
            TG   P +   NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 947  TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNY 1004

Query: 388  FMINLCLVVIATQF 401
             + NL + ++   F
Sbjct: 1005 VLFNLLVAILVEGF 1018



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 2/74 (2%)

Query: 759 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNY 816
           +GD+ P     NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 349 SGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSF 408

Query: 817 VLFNLLVAILVEGF 830
            + NL + ++   F
Sbjct: 409 FMINLCLVVIATQF 422



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            D NP  G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 351  DSNPHNGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YYVMDAHSFYNF 396

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 397  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431



 Score = 35.8 bits (81), Expect = 0.47
 Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 332  NPHKGA---INFDNIGYAWIVIFQVITLEGWVEIMYYVM------DAHSFYNF-----IY 377
            NP +G      F N G A++ +F+V T + W  IM   +      D H          +Y
Sbjct: 1774 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1833

Query: 378  FILLIIVGSFFMINLCLVVIATQFSETKQ 406
            F+  ++V  F ++N+ + V+     E+ +
Sbjct: 1834 FVTFVLVAQFVLVNVVVAVLMKHLEESNK 1862


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 1599 bits (4140), Expect = 0.0
 Identities = 921/1630 (56%), Positives = 1079/1630 (66%), Gaps = 147/1630 (9%)

Query: 467  LGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDG 526
            L   +P P +  PH          P H    + P  L  P   TL  +  SCP C     
Sbjct: 649  LSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALE 708

Query: 527  RRPSGLGSTDSGQEGSGSGSSAGGEDEADGDG-------ARSSEDGASSELGKEEEEEEQ 579
                 L  ++SG +  G G     +D   GD          +   G      +   ++  
Sbjct: 709  DPEGELSGSESG-DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRA 767

Query: 580  ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 639
            A G     G +W     KLR IVDSKYF+RGIMMAILVNT+SMG+E+HEQPEELTN LEI
Sbjct: 768  APGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEI 827

Query: 640  CNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFR 699
             N+VFTSMFALEM+LKL A G   Y+RNPYNIFD IIV+IS+WEIVGQADGGLSVLRTFR
Sbjct: 828  SNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFR 887

Query: 700  LLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDT 759
            LLRVLKLVRF+PALRRQLVVL+KTMDNVATFC LLMLFIFIFSILGMH+FGCKFSL+TDT
Sbjct: 888  LLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDT 947

Query: 760  GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLF 819
            GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS WA+LYFVALMTFGNYVLF
Sbjct: 948  GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF 1007

Query: 820  NLLVAILVEGFQAEGDANRSYSDEDQSSSNIEE-FDKLQEGLDSSGDPKLCPIPMTPNGH 878
            NLLVAILVEGFQAEGDANRS +DED++S + EE F KL+E    + + K+C + +TPNGH
Sbjct: 1008 NLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLREL--QTTELKMCSLAVTPNGH 1065

Query: 879  LDPSLPLGGHLGPAGAAGPAPRLSLQP--DPMLVALGSRKSSVMSLGRMSYDQRSLSSSR 936
            L+    L   L    AA P P     P  D       SR+ S  S      DQ+  +S R
Sbjct: 1066 LEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLR 1125

Query: 937  SSYYGPWGRSAAWASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEG 990
            SS   PWG S AW+SRRSSW+SL      K +    E ESLLS E  G     +  A++G
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGST---DDEAEDG 1182

Query: 991  PPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAA 1050
              RAAP           GP    R    RR  SLD                 PR    AA
Sbjct: 1183 --RAAP-----------GP----RATPLRRAESLD-----------------PRPLRPAA 1208

Query: 1051 GPAPGHEDCNGRMPSIAKDVFTKMGD-RGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEV 1109
             P     D +G++ ++  D F ++   R D  E +++ + + C R+ K+++ YKP WC  
Sbjct: 1209 LPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRS 1268

Query: 1110 REDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFL 1169
            RE W++YLFSP+NRFRV CQ +I HK+FD+VVL FIFLNC+TIALERP I+ GSTER+FL
Sbjct: 1269 REAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFL 1328

Query: 1170 TVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGG 1229
            +VSNYIFTAIFV EM +KVV+LGL  GE AYL+SSWN+LDG LV VS++DIVV++ASAGG
Sbjct: 1329 SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGG 1388

Query: 1230 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILG 1289
            AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL+PIGNIVLICCAFFIIFGILG
Sbjct: 1389 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILG 1448

Query: 1290 VQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVN 1349
            VQLFKGKFY+C G DTRNI+ ++ C AA+YRWV  KYNFDNLGQALMSLFVL+SKDGWVN
Sbjct: 1449 VQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVN 1508

Query: 1350 IMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1409
            IMY+GLDAV VDQQPV NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE
Sbjct: 1509 IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1568

Query: 1410 EARRREEKRLRRLEKKRR------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1463
            EARRREEKRLRRLE++RR      +AQR PYYA Y  TR  IHS+CTSHYLD+FITFIIC
Sbjct: 1569 EARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIIC 1628

Query: 1464 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1523
            +NV+TMS+EHYNQP SL+ ALKYCNY+FT VFV EA LKLVAFG RRFFKDRWNQLDLAI
Sbjct: 1629 VNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAI 1688

Query: 1524 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1583
            VLLS+MGITLEEIE++AALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ
Sbjct: 1689 VLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1748

Query: 1584 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
            VGNLGLLFMLLFFIYAALGVELFG+L C+++NPCEG+SRHATF NFGMAFLTLF+VSTGD
Sbjct: 1749 VGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGD 1808

Query: 1644 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1703
            NWNGIMKDTLR+C+ +++ CLS L  +SP+YFV+FVL AQFVL+NVVVAVLMKHL++SNK
Sbjct: 1809 NWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868

Query: 1704 EAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQ 1763
            EA+EDAE+DAE+ELEMA G G   R+    P  P   PG                     
Sbjct: 1869 EAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGAR------------------- 1909

Query: 1764 ENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSL 1823
                 D+ +L+ +      +  + N S     +   P       H +  +Q  E E +  
Sbjct: 1910 -----DAPNLVARKVSVSRMLSLPNDS-----YMFRPVVPASAPHPR-PLQEVEMETYGA 1958

Query: 1824 NSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPP----EPMRVGDLGECFFPLSSTAV 1879
             +       LG   S+  P A      +S   L  P     P R G+      P   TA 
Sbjct: 1959 GTP------LGSVASVHSPPA------ESCASLQIPLAVSSPARSGEPLHALSP-RGTAR 2005

Query: 1880 SPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQK 1939
            SP     LC  E +  + +    K DS +    P  P   +P+ P+              
Sbjct: 2006 SPSLSRLLCRQEAVHTDSLEG--KIDSPRDTLDPAEPGEKTPVRPV-------------- 2049

Query: 1940 GPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLED 1999
                 T  G+L         +  RSPR      R+ T     + + P++  G      + 
Sbjct: 2050 -----TQGGSLQ--------SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDP 2096

Query: 2000 S------LTLSDSPRRALGPP-APAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQ-RS 2051
            +      +T S  P +    P  P   P AG     RR  S+  +G     G    Q R 
Sbjct: 2097 ADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRP 2156

Query: 2052 HSSGGSTSPG 2061
             +  GS  PG
Sbjct: 2157 SAELGSGEPG 2166



 Score =  624 bits (1608), Expect = e-178
 Identities = 320/504 (63%), Positives = 371/504 (73%), Gaps = 18/504 (3%)

Query: 7   PPSSSAAAPAAEPGVTTEQPGPRS-----------PPSSPPGLEEPLD-GADPH--VPHP 52
           P  +    PAA  G + E PG               PS  P  E   + GAD    VP+P
Sbjct: 14  PLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYP 73

Query: 53  DLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRC 112
            LA   FFCL QTT PR+WC+++VCNPWFE VSMLVI+LNCVTLGM++PC+D++C S+RC
Sbjct: 74  ALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133

Query: 113 KILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNI 172
            IL+ FD FIF FFA+EMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  N+
Sbjct: 134 NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV 193

Query: 173 NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
           +LSAIRTVRVLRPL+AINRVPSMRILV LLLDTLPMLGNVLLLCFFVFFIFGI+GVQLWA
Sbjct: 194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253

Query: 233 GLLRNRCFLEENFTIQGDVA-LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGR 291
           GLLRNRCFL+  F    ++  L PYYQ EE +E PFICS   DNG+  C  IP  +E   
Sbjct: 254 GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRM 313

Query: 292 ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIF 351
            C L   + Y          A   C+NWN+YYNVCR+G +NPH GAINFDNIGYAWI IF
Sbjct: 314 PCTLGW-EAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIF 372

Query: 352 QVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRL 411
           QVITLEGWV+IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE +L
Sbjct: 373 QVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 432

Query: 412 MLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR-RQALGP 469
           M EQR R+LS+ ST+AS++EPG CYEE+ +YV HI RK KRR+L LY   QSR R+ + P
Sbjct: 433 MREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDP 492

Query: 470 EAPAPAKPGPHAKEPRHYQLCPQH 493
            A     PG   +    +     H
Sbjct: 493 SAVQGQGPGHRQRRAGRHTASVHH 516



 Score =  116 bits (290), Expect = 3e-25
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 10/192 (5%)

Query: 1123 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTERIFLTVSNYIFTAIF 1180
            R R  C  ++ +  F++V +  I LNC+T+ + RP   +E GS     L   +    A F
Sbjct: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147

Query: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240
              EM +K+V+LGL FG++ YL  +WN LD F+V   +++      S  G  +   L  +R
Sbjct: 148  AVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEY-----SLDGHNVS--LSAIR 199

Query: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300
             +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G   + 
Sbjct: 200  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259

Query: 1301 LGVDTRNITNRS 1312
              +D+  + N +
Sbjct: 260  CFLDSAFVRNNN 271



 Score =  109 bits (272), Expect = 3e-23
 Identities = 60/170 (35%), Positives = 100/170 (58%), Gaps = 10/170 (5%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131
            C K++ +  F+ V ++ I LNCVT+ + +P  D+D  S     L V +      F  EM+
Sbjct: 1287 CQKVITHKMFDHVVLVFIFLNCVTIALERP--DIDPGSTERVFLSVSNYIFTAIFVAEMM 1344

Query: 132  LKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRVL 183
            +K+VALG+  G+  YL  +WN LD  +V+  +V+  + + +         L  +R +R L
Sbjct: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404

Query: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            RPL+ I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G
Sbjct: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 29/252 (11%)

Query: 525 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS--------------SEL 570
           +G R +       G    G  +  G   E+ G   R +E G+               +EL
Sbjct: 3   EGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAEL 62

Query: 571 GKEEEEE---EQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI--- 624
           G +EE+          V+ C       R+    +V + +F    M+ I++N V++G+   
Sbjct: 63  GADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP 122

Query: 625 -EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFD---YLRNPYNIFDSIIVIIS 680
            E  E   E  NILE  +    + FA+EM++K+ A GLF    YL + +N  D  IV+  
Sbjct: 123 CEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAG 182

Query: 681 IWEIVGQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLF 737
           + E     DG    LS +RT R+LR L+ +  +P++R  + +L+ T+  +    +L    
Sbjct: 183 MMEY--SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240

Query: 738 IFIFSILGMHIF 749
            FIF I+G+ ++
Sbjct: 241 FFIFGIVGVQLW 252



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 51/180 (28%), Positives = 88/180 (48%), Gaps = 21/180 (11%)

Query: 67   SPRNWCIKMVCNP-WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF 125
            SP    I  +C   + +     +I +N +T+ M +  +    L +  K        +F+F
Sbjct: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSM-EHYNQPKSLDEALKYCNYVFTIVFVF 1662

Query: 126  FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA--------- 176
               E  LK+VA   FG + +  D WN+LD  IV+  ++   + L+ I +SA         
Sbjct: 1663 ---EAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINPTII 1714

Query: 177  --IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
              +R +R+ R LK +     MR L++ ++  LP +GN+ LL   +FFI+  +GV+L+  L
Sbjct: 1715 RIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRL 1774



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 46/161 (28%), Positives = 82/161 (50%), Gaps = 20/161 (12%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETALKYCNYM------FTTVFVLEAVLKLVAFGL---RRF 1511
            +I LN VT+ +  +     +E   + CN +          F +E V+K+VA GL   + +
Sbjct: 109  VIMLNCVTLGM--FRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCY 166

Query: 1512 FKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1571
              D WN+LD  IV+  +M  +L+   ++         +  +R +R+ R L+ +     MR
Sbjct: 167  LGDTWNRLDFFIVVAGMMEYSLDGHNVS---------LSAIRTVRVLRPLRAINRVPSMR 217

Query: 1572 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
             L+  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 218  ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 45/161 (27%), Positives = 84/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           ++V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQP-------EELTNALEISNIVFTSMFALEM 840

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++A G  G   Y+ + +N  D  IV+  + E  +   +  LS +RT R+LR LK + 
Sbjct: 841 LLKLLACGPLG---YIRNPYNIFDGIIVVISVWEI-VGQADGGLSVLRTFRLLRVLKLVR 896

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P++R  + +L+ T+  +     L     FIF I+G+ L+
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 31/96 (32%), Positives = 56/96 (58%), Gaps = 14/96 (14%)

Query: 1327 NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFF 1386
            NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  +YFI  +++ SFF
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIVGSFF 409

Query: 1387 VLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
            ++N+ + V+   F + +Q     E++   E+R R L
Sbjct: 410  MINLCLVVIATQFSETKQ----RESQLMREQRARHL 441



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 35/120 (29%), Positives = 60/120 (50%), Gaps = 14/120 (11%)

Query: 326  CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNF 375
            CR       +   NFDN+G A + +F + + +GWV IMY  +DA          H+ +  
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532

Query: 376  IYFILLIIVGSFFMINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431
            +YFI  +++ SFF++N+ + V+   F + +Q     E R   E+R R L     +++  P
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSP 1592



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 2/74 (2%)

Query: 328  TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSF 387
            TG   P +   NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 947  TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNY 1004

Query: 388  FMINLCLVVIATQF 401
             + NL + ++   F
Sbjct: 1005 VLFNLLVAILVEGF 1018



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 2/74 (2%)

Query: 759 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNY 816
           +GD+ P     NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 349 SGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSF 408

Query: 817 VLFNLLVAILVEGF 830
            + NL + ++   F
Sbjct: 409 FMINLCLVVIATQF 422



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            D NP  G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 351  DSNPHNGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YYVMDAHSFYNF 396

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 397  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431



 Score = 35.8 bits (81), Expect = 0.47
 Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 332  NPHKGA---INFDNIGYAWIVIFQVITLEGWVEIMYYVM------DAHSFYNF-----IY 377
            NP +G      F N G A++ +F+V T + W  IM   +      D H          +Y
Sbjct: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839

Query: 378  FILLIIVGSFFMINLCLVVIATQFSETKQ 406
            F+  ++V  F ++N+ + V+     E+ +
Sbjct: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score = 1507 bits (3902), Expect = 0.0
 Identities = 924/1753 (52%), Positives = 1100/1753 (62%), Gaps = 210/1753 (11%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1437
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR       +AQ  PYY+ 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562

Query: 1438 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1497
            Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622

Query: 1498 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557
            E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1617
            ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742

Query: 1618 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1677
            EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C +++  +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGS---- 1733
            FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P P  P GS    
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSPFLW 1858

Query: 1734 PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIID 1787
            PG  G        PG                  P    L+ D++SL+I+ SLE EL ++D
Sbjct: 1859 PGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMD 1917

Query: 1788 NLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSILLGDDLSLEDP- 1842
             L+G      + P+       D Q + LAE EA SL     S+ S S+ L DD SL D  
Sbjct: 1918 ELAGPGGQPSAFPSAPSLGGSDPQ-IPLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDM 1975

Query: 1843 -----TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
                 +A     +    EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1976 HTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 2029

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 2030 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTIPKL 2083

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 2084 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2138

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2139 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2198

Query: 2035 ------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2199 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2255

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2256 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2310

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2311 ASGPPDSMAASPS 2323



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQFSETKQREHRLMLEQRQR 418
            ++N+ + V+   F   K R+H+   E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 35.0 bits (79), Expect = 0.81
 Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1811 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1855

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
                     L+  ++      GP++P   KPG      HA+   H+ L
Sbjct: 1856 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1889


>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
            isoform 2 [Homo sapiens]
          Length = 2354

 Score = 1503 bits (3891), Expect = 0.0
 Identities = 924/1764 (52%), Positives = 1100/1764 (62%), Gaps = 221/1764 (12%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1427
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR                 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562

Query: 1428 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1486
             +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK 
Sbjct: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622

Query: 1487 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1546
            CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682

Query: 1547 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1606
            TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742

Query: 1607 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1666
            G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C ++
Sbjct: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801

Query: 1667 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1726
            +  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P 
Sbjct: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858

Query: 1727 PRLPTGS----PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIK 1776
            P  P GS    PG  G        PG                  P    L+ D++SL+I+
Sbjct: 1859 PHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQ 1917

Query: 1777 DSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSIL 1832
             SLE EL ++D L+G      + P+       D Q + LAE EA SL     S+ S S+ 
Sbjct: 1918 GSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ-IPLAEMEALSLTSEIVSEPSCSLA 1976

Query: 1833 LGDDLSLEDP------TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENF 1886
            L DD SL D       +A     +    EL  P+ + V   G     +S T   P+ +++
Sbjct: 1977 LTDD-SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSY 2029

Query: 1887 LCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPE 1942
            +C        P+  R W   K  S         P  +S +L +P +  H         P 
Sbjct: 2030 MCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPH 2083

Query: 1943 KGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSS 1988
                 GT+PK+   G     RSP     L RQA     SLD              + PS 
Sbjct: 2084 SAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP 2138

Query: 1989 SAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL---- 2034
                  +    S T +    R+       + PPAP PGP        P  R  L L    
Sbjct: 2139 PLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTEL 2198

Query: 2035 -----------------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTH 2064
                               R L     + A             QR HS   S    G   
Sbjct: 2199 SWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQP 2258

Query: 2065 HDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSS 2120
            H   DPS+    GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S
Sbjct: 2259 HLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPS 2314

Query: 2121 TSSLAAPGRPHAAALAHGLARSPS 2144
            + S      P A+     +A SPS
Sbjct: 2315 SDS----KDPLASGPPDSMAASPS 2334



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564

Query: 432  GDC 434
              C
Sbjct: 1565 AQC 1567



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 35.0 bits (79), Expect = 0.81
 Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1822 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1866

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
                     L+  ++      GP++P   KPG      HA+   H+ L
Sbjct: 1867 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1900


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score = 1490 bits (3857), Expect = 0.0
 Identities = 924/1787 (51%), Positives = 1100/1787 (61%), Gaps = 244/1787 (13%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502

Query: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
            QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562

Query: 1422 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1463
            LEKKRR                  +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I 
Sbjct: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622

Query: 1464 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1523
            LNVVTM++EHY QP  L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682

Query: 1524 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1583
            VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742

Query: 1584 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
            VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802

Query: 1644 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1703
            NWNGIMKDTLRDC   E +C +++  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859

Query: 1704 EAQEDAEMDAELELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGG 1753
            EA+E+AE++AELELEM   L P P  P GS    PG  G        PG           
Sbjct: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSA 1918

Query: 1754 LCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEV 1813
                   P    L+ D++SL+I+ SLE EL ++D L+G      + P+       D Q +
Sbjct: 1919 SHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ-I 1976

Query: 1814 QLAETEAFSLN----SDRSSSILLGDDLSLEDP------TACPPGRKDSKGELDPPEPMR 1863
             LAE EA SL     S+ S S+ L DD SL D       +A     +    EL  P+ + 
Sbjct: 1977 PLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDMHTLLLSALESNMQPHPTELPGPDLLT 2035

Query: 1864 VGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDAS 1919
            V   G     +S T   P+ ++++C        P+  R W   K  S         P  +
Sbjct: 2036 VRKSG-----VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADT 2089

Query: 1920 SPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSD 1979
            S +L +P +  H         P      GT+PK+   G     RSP     L RQA    
Sbjct: 2090 SYILQLPKDAPH------LLQPHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRT 2138

Query: 1980 TSLD--------------ASPSSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAP 2018
             SLD              + PS       +    S T +    R+       + PPAP P
Sbjct: 2139 DSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCP 2198

Query: 2019 GPRAGLS---PAARRRLSL---------------------RGRGLFSLRGLRA------- 2047
            GP        P  R  L L                       R L     + A       
Sbjct: 2199 GPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRP 2258

Query: 2048 -----HQRSHSSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLF 2101
                  QR HS   S    G   H   DPS+    GG   GG GS   + LS  S+T + 
Sbjct: 2259 TSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-ID 2314

Query: 2102 CP----PPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPS 2144
             P    P  PP+PG+   R+  S+ S      P A+     +A SPS
Sbjct: 2315 PPESQGPRTPPSPGICLRRRAPSSDS----KDPLASGPPDSMAASPS 2357



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587

Query: 432  GDC 434
              C
Sbjct: 1588 AQC 1590



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 35.0 bits (79), Expect = 0.81
 Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1845 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1889

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
                     L+  ++      GP++P   KPG      HA+   H+ L
Sbjct: 1890 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1923


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score = 1489 bits (3854), Expect = 0.0
 Identities = 913/1743 (52%), Positives = 1085/1743 (62%), Gaps = 235/1743 (13%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1437
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR       +AQ  PYY+ 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562

Query: 1438 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1497
            Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622

Query: 1498 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557
            E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1617
            ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742

Query: 1618 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1677
            EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C +++  +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGS---- 1733
            FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P P  P GS    
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSPFLW 1858

Query: 1734 PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIID 1787
            PG  G        PG                  P    L+ D++SL+I+ SLE EL ++D
Sbjct: 1859 PGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMD 1917

Query: 1788 NLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPP 1847
             L+G        P G              +  AF      S+  L G D          P
Sbjct: 1918 ELAG--------PGG--------------QPSAFP-----SAPSLGGSD----------P 1940

Query: 1848 GRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV--RSW--LK 1903
              +    EL  P+ + V   G     +S T   P+ ++++C        P+  R W   K
Sbjct: 1941 QMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPK 1994

Query: 1904 HDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLR 1963
              S         P  +S +L +P +  H         P      GT+PK+   G     R
Sbjct: 1995 AQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTIPKLPPPG-----R 2043

Query: 1964 SPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLEDSLTLSDSPRR 2009
            SP     L RQA     SLD              + PS       +    S T +    R
Sbjct: 2044 SPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSR 2103

Query: 2010 A-------LGPPAPAPGPRAGLS---PAARRRLSL---------------------RGRG 2038
            +       + PPAP PGP        P  R  L L                       R 
Sbjct: 2104 SHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRD 2163

Query: 2039 LFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAG 2085
            L     + A             QR HS   S    G   H   DPS+    GG   GG G
Sbjct: 2164 LKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPG 2220

Query: 2086 SEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLAR 2141
            S   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P A+     +A 
Sbjct: 2221 SRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPLASGPPDSMAA 2275

Query: 2142 SPS 2144
            SPS
Sbjct: 2276 SPS 2278



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQFSETKQREHRLMLEQRQR 418
            ++N+ + V+   F   K R+H+   E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 35.0 bits (79), Expect = 0.81
 Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1811 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1855

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
                     L+  ++      GP++P   KPG      HA+   H+ L
Sbjct: 1856 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1889


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score = 1476 bits (3820), Expect = 0.0
 Identities = 913/1766 (51%), Positives = 1085/1766 (61%), Gaps = 258/1766 (14%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502

Query: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
            QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562

Query: 1422 LEKKRR-------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474
            LEKKRR       +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY
Sbjct: 1563 LEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHY 1622

Query: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534
             QP  L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLE
Sbjct: 1623 QQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLE 1682

Query: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594
            EIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLL
Sbjct: 1683 EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLL 1742

Query: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654
            FFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLR
Sbjct: 1743 FFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR 1802

Query: 1655 DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAE 1714
            DC   E +C +++  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AE
Sbjct: 1803 DC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1859

Query: 1715 LELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQE 1764
            LELEM   L P P  P GS    PG  G        PG                  P   
Sbjct: 1860 LELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDR 1918

Query: 1765 NLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN 1824
             L+ D++SL+I+ SLE EL ++D L+G        P G              +  AF   
Sbjct: 1919 QLF-DTISLLIQGSLEWELKLMDELAG--------PGG--------------QPSAFP-- 1953

Query: 1825 SDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPE 1884
               S+  L G D          P  +    EL  P+ + V   G     +S T   P+ +
Sbjct: 1954 ---SAPSLGGSD----------PQMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-D 1994

Query: 1885 NFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKG 1940
            +++C        P+  R W   K  S         P  +S +L +P +  H         
Sbjct: 1995 SYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQ 2048

Query: 1941 PEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASP 1986
            P      GT+PK+   G     RSP     L RQA     SLD              + P
Sbjct: 2049 PHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGP 2103

Query: 1987 SSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL-- 2034
            S       +    S T +    R+       + PPAP PGP        P  R  L L  
Sbjct: 2104 SPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDT 2163

Query: 2035 -------------------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGC 2062
                                 R L     + A             QR HS   S    G 
Sbjct: 2164 ELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGS 2223

Query: 2063 THHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKF 2118
              H   DPS+    GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+ 
Sbjct: 2224 QPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRA 2279

Query: 2119 SSTSSLAAPGRPHAAALAHGLARSPS 2144
             S+ S      P A+     +A SPS
Sbjct: 2280 PSSDS----KDPLASGPPDSMAASPS 2301



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1659

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1660 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1719

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1720 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 389  MINLCLVVIATQFSETKQREHRLMLEQRQR 418
            ++N+ + V+   F   K R+H+   E R+R
Sbjct: 1528 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1555



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 35.0 bits (79), Expect = 0.81
 Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1774 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1833

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1834 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1878

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
                     L+  ++      GP++P   KPG      HA+   H+ L
Sbjct: 1879 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1912


>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score = 1474 bits (3815), Expect = 0.0
 Identities = 911/1756 (51%), Positives = 1080/1756 (61%), Gaps = 253/1756 (14%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1427
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR                 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562

Query: 1428 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1486
             +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK 
Sbjct: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622

Query: 1487 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1546
            CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682

Query: 1547 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1606
            TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742

Query: 1607 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1666
            G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C ++
Sbjct: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801

Query: 1667 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1726
            +  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P 
Sbjct: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858

Query: 1727 PRLPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELT 1784
            P  P GSP   PG  GP                  SP                       
Sbjct: 1859 PHSPLGSPFLWPGVEGPD-----------------SP----------------------- 1878

Query: 1785 IIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSILLGDDLSLE 1840
              D+      H  +          +   + LAE EA SL     S+ S S+ L DD SL 
Sbjct: 1879 --DSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLP 1935

Query: 1841 DP------TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIP 1894
            D       +A     +    EL  P+ + V   G     +S T   P+ ++++C      
Sbjct: 1936 DDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTA 1989

Query: 1895 FNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTL 1950
              P+  R W   K  S         P  +S +L +P +  H         P      GT+
Sbjct: 1990 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTI 2043

Query: 1951 PKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTT 1996
            PK+   G     RSP     L RQA     SLD              + PS       + 
Sbjct: 2044 PKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSF 2098

Query: 1997 LEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL------------ 2034
               S T +    R+       + PPAP PGP        P  R  L L            
Sbjct: 2099 WGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLL 2158

Query: 2035 ---------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSD 2072
                       R L     + A             QR HS   S    G   H   DPS+
Sbjct: 2159 PPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN 2218

Query: 2073 EEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPG 2128
                GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S     
Sbjct: 2219 ---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----K 2270

Query: 2129 RPHAAALAHGLARSPS 2144
             P A+     +A SPS
Sbjct: 2271 DPLASGPPDSMAASPS 2286



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564

Query: 432  GDC 434
              C
Sbjct: 1565 AQC 1567



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.0 bits (84), Expect = 0.21
 Identities = 42/195 (21%), Positives = 72/195 (36%), Gaps = 44/195 (22%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1822 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1866

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQP 506
                     L+  ++      GP++P   KPG  A  P  +     H  L+     L + 
Sbjct: 1867 --------FLWPGVE------GPDSPDSPKPG--ALHPAAHARSASHFSLEHPTIPLAEM 1910

Query: 507  IPATLASDPASCPCC 521
               +L S+  S P C
Sbjct: 1911 EALSLTSEIVSEPSC 1925


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score = 1471 bits (3809), Expect = 0.0
 Identities = 913/1777 (51%), Positives = 1085/1777 (61%), Gaps = 269/1777 (15%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502

Query: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
            QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562

Query: 1422 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1463
            LEKKRR                  +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I 
Sbjct: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622

Query: 1464 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1523
            LNVVTM++EHY QP  L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682

Query: 1524 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1583
            VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742

Query: 1584 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
            VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802

Query: 1644 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1703
            NWNGIMKDTLRDC   E +C +++  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859

Query: 1704 EAQEDAEMDAELELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGG 1753
            EA+E+AE++AELELEM   L P P  P GS    PG  G        PG           
Sbjct: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSA 1918

Query: 1754 LCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEV 1813
                   P    L+ D++SL+I+ SLE EL ++D L+G        P G           
Sbjct: 1919 SHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMDELAG--------PGG----------- 1958

Query: 1814 QLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFP 1873
               +  AF      S+  L G D          P  +    EL  P+ + V   G     
Sbjct: 1959 ---QPSAFP-----SAPSLGGSD----------PQMQPHPTELPGPDLLTVRKSG----- 1995

Query: 1874 LSSTAVSPDPENFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEF 1929
            +S T   P+ ++++C        P+  R W   K  S         P  +S +L +P + 
Sbjct: 1996 VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA 2054

Query: 1930 FHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD------ 1983
             H         P      GT+PK+   G     RSP     L RQA     SLD      
Sbjct: 2055 PH------LLQPHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS 2103

Query: 1984 --------ASPSSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS--- 2025
                    + PS       +    S T +    R+       + PPAP PGP        
Sbjct: 2104 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2163

Query: 2026 PAARRRLSL---------------------RGRGLFSLRGLRA------------HQRSH 2052
            P  R  L L                       R L     + A             QR H
Sbjct: 2164 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2223

Query: 2053 SSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPP 2107
            S   S    G   H   DPS+    GG   GG GS   + LS  S+T +  P    P  P
Sbjct: 2224 SIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTP 2279

Query: 2108 PAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPS 2144
            P+PG+   R+  S+ S      P A+     +A SPS
Sbjct: 2280 PSPGICLRRRAPSSDS----KDPLASGPPDSMAASPS 2312



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587

Query: 432  GDC 434
              C
Sbjct: 1588 AQC 1590



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 35.0 bits (79), Expect = 0.81
 Identities = 36/168 (21%), Positives = 63/168 (37%), Gaps = 47/168 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1845 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1889

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQL 489
                     L+  ++      GP++P   KPG      HA+   H+ L
Sbjct: 1890 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL 1923


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score = 1469 bits (3804), Expect = 0.0
 Identities = 798/1250 (63%), Positives = 927/1250 (74%), Gaps = 89/1250 (7%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLL 1444
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRRKAQ  PYY+ Y   RLL
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLL 1562

Query: 1445 IHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLV 1504
            +H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK CNY+FT +FVLE+V KLV
Sbjct: 1563 VHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLV 1622

Query: 1505 AFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLL 1564
            AFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLL
Sbjct: 1623 AFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLL 1682

Query: 1565 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHA 1624
            KMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHA
Sbjct: 1683 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1742

Query: 1625 TFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQF 1684
            TF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C +++  +SP+YFVSFVLTAQF
Sbjct: 1743 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQF 1799

Query: 1685 VLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1734
            VL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P P  P GSP
Sbjct: 1800 VLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1848



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1579 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1629

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1630 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1689

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1690 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1727



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 32/107 (29%), Positives = 57/107 (53%), Gaps = 14/107 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431
            ++N+ + V+   F + +Q     E R   E+R R L      +  +P
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKP 1551



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1881 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1929

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1930 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1983

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 1984 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2038

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2039 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2098

Query: 2035 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2099 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2155

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2156 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2210

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2211 ASGPPDSMAASPS 2223



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1744 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1803

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1804 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1848

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1849 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1892

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1893 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1943


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score = 1461 bits (3782), Expect = 0.0
 Identities = 797/1257 (63%), Positives = 927/1257 (73%), Gaps = 96/1257 (7%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1437
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR       +AQ  PYY+ 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562

Query: 1438 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1497
            Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622

Query: 1498 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557
            E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1617
            ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742

Query: 1618 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1677
            EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C +++  +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1734
            FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P P  P GSP
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1855



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQFSETKQREHRLMLEQRQR 418
            ++N+ + V+   F   K R+H+   E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1888 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1936

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1937 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1990

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 1991 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2045

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2046 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2105

Query: 2035 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2106 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2162

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2163 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2217

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2218 ASGPPDSMAASPS 2230



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1811 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1855

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1856 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1899

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1900 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1950


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score = 1461 bits (3782), Expect = 0.0
 Identities = 797/1257 (63%), Positives = 927/1257 (73%), Gaps = 96/1257 (7%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1437
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR       +AQ  PYY+ 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562

Query: 1438 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1497
            Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622

Query: 1498 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557
            E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1617
            ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742

Query: 1618 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1677
            EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C +++  +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1734
            FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P P  P GSP
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1855



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQFSETKQREHRLMLEQRQR 418
            ++N+ + V+   F   K R+H+   E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 84/315 (26%), Positives = 114/315 (36%), Gaps = 59/315 (18%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1888 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1936

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1937 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1990

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGP 2013
               G     RSP     L RQA     SLD     S         + L   + P      
Sbjct: 1991 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS--------REDLLAEEEP------ 2031

Query: 2014 PAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDE 2073
                P PR      +    S + R    L   R H  + S   S   G   H   DPS+ 
Sbjct: 2032 ----PSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS---GSQPHLGTDPSN- 2083

Query: 2074 EGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGR 2129
               GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      
Sbjct: 2084 --LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KD 2136

Query: 2130 PHAAALAHGLARSPS 2144
            P A+     +A SPS
Sbjct: 2137 PLASGPPDSMAASPS 2151



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1811 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1855

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1856 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1899

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1900 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1950


>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
            isoform 11 [Homo sapiens]
          Length = 2261

 Score = 1457 bits (3771), Expect = 0.0
 Identities = 797/1268 (62%), Positives = 927/1268 (73%), Gaps = 107/1268 (8%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 868
            ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D  S +          LD  GD K 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995

Query: 869  CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 911
            C   ++   H       L P          SLP     G   A GPA R +         
Sbjct: 996  CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046

Query: 912  LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 965
                 SS  +    +++ +S  S+RSS + PW  +++W SRRSS NSL      K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102

Query: 966  AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1025
             E  SLLS E G  ++  E +++E   RA+P  + H                HR +L  +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144

Query: 1026 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1084
             + S DL + +   G H  A+ R  G A  H+DCNG+  S       +  D    G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202

Query: 1085 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1144
            +E + +   RVR  I    P  C  R+ WS Y+F P++RFR+LC  II HK+FD+VVL  
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262

Query: 1145 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1204
            IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+ EMT+KVV+LG  FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322

Query: 1205 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1264
            WNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382

Query: 1265 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1324
            +SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC  A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442

Query: 1325 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1384
            KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502

Query: 1385 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1427
            FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR                 
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562

Query: 1428 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1486
             +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+ ALK 
Sbjct: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622

Query: 1487 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1546
            CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682

Query: 1547 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1606
            TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742

Query: 1607 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1666
            G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E +C ++
Sbjct: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801

Query: 1667 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1726
            +  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM   L P 
Sbjct: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858

Query: 1727 PRLPTGSP 1734
            P  P GSP
Sbjct: 1859 PHSPLGSP 1866



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504

Query: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564

Query: 432  GDC 434
              C
Sbjct: 1565 AQC 1567



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 25/245 (10%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQ 458
              F    Q E      + +    S ++    +   C   +       LRK+    L ++ 
Sbjct: 965  EGF----QAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHT 1020

Query: 459  ALQSRR----------QALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIP 508
            A               +ALGP +   +  G       H    P  +   ++PH+     P
Sbjct: 1021 AATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSA--RSSPHS-----P 1073

Query: 509  ATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASS 568
             + AS   S    ++  GR PS    + SG+      S   GE +   D   SSE+  +S
Sbjct: 1074 WSAASSWTSRRSSRNSLGRAPSLKRRSPSGER----RSLLSGEGQESQDEEESSEEERAS 1129

Query: 569  ELGKE 573
              G +
Sbjct: 1130 PAGSD 1134



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1899 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1947

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1948 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2001

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 2002 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2056

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2057 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2116

Query: 2035 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2117 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2173

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2174 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2228

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2229 ASGPPDSMAASPS 2241



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1822 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1866

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1867 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1910

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1911 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1961


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score = 1456 bits (3770), Expect = 0.0
 Identities = 798/1273 (62%), Positives = 927/1273 (72%), Gaps = 112/1273 (8%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502

Query: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
            QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562

Query: 1422 LEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLE 1481
            LEKKRRKAQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP  L+
Sbjct: 1563 LEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD 1622

Query: 1482 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1541
             ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+
Sbjct: 1623 EALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1682

Query: 1542 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1601
            LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AAL
Sbjct: 1683 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1742

Query: 1602 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDER 1661
            GVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC   E 
Sbjct: 1743 GVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQES 1801

Query: 1662 SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAH 1721
            +C +++  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM  
Sbjct: 1802 TCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-K 1858

Query: 1722 GLGPGPRLPTGSP 1734
             L P P  P GSP
Sbjct: 1859 TLSPQPHSPLGSP 1871



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1602 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1652

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1653 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1712

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1713 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1750



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 32/107 (29%), Positives = 57/107 (53%), Gaps = 14/107 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 389  MINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431
            ++N+ + V+   F + +Q     E R   E+R R L      +  +P
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKP 1574



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1904 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1952

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1953 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2006

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 2007 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2061

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2062 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2121

Query: 2035 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2122 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2178

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2179 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2233

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2234 ASGPPDSMAASPS 2246



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1767 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1826

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1827 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1871

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1872 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1915

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1916 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1966


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score = 1448 bits (3748), Expect = 0.0
 Identities = 797/1280 (62%), Positives = 927/1280 (72%), Gaps = 119/1280 (9%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502

Query: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
            QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562

Query: 1422 LEKKRR-------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474
            LEKKRR       +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I LNVVTM++EHY
Sbjct: 1563 LEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHY 1622

Query: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534
             QP  L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLE
Sbjct: 1623 QQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLE 1682

Query: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594
            EIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLL
Sbjct: 1683 EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLL 1742

Query: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654
            FFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLR
Sbjct: 1743 FFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR 1802

Query: 1655 DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAE 1714
            DC   E +C +++  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AE
Sbjct: 1803 DC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1859

Query: 1715 LELEMAHGLGPGPRLPTGSP 1734
            LELEM   L P P  P GSP
Sbjct: 1860 LELEM-KTLSPQPHSPLGSP 1878



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1659

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1660 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1719

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1720 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 389  MINLCLVVIATQFSETKQREHRLMLEQRQR 418
            ++N+ + V+   F   K R+H+   E R+R
Sbjct: 1528 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1555



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1911 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1959

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1960 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2013

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 2014 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2068

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2069 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2128

Query: 2035 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2129 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2185

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2186 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2240

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2241 ASGPPDSMAASPS 2253



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1774 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1833

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1834 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1878

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1879 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1922

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1923 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1973


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score = 1444 bits (3737), Expect = 0.0
 Identities = 797/1291 (61%), Positives = 927/1291 (71%), Gaps = 130/1291 (10%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1361
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502

Query: 1362 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1421
            QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562

Query: 1422 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1463
            LEKKRR                  +AQ  PYY+ Y   RLL+H +CTSHYLD+FIT +I 
Sbjct: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622

Query: 1464 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1523
            LNVVTM++EHY QP  L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682

Query: 1524 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1583
            VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742

Query: 1584 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
            VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802

Query: 1644 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1703
            NWNGIMKDTLRDC   E +C +++  +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859

Query: 1704 EAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1734
            EA+E+AE++AELELEM   L P P  P GSP
Sbjct: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSP 1889



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)

Query: 88   VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
            VI LN VT+ M  YQ    +D      + L++ +    + F +E V K+VA   FG + +
Sbjct: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670

Query: 146  LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
              D WN+LD  IV+  ++  +L+   +N S          +R +R+ R LK +     MR
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730

Query: 197  ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
             L++ ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
            NFDN+G A + +F + + +GWV+IMY  +DA          H+ +  +YFI  +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527

Query: 389  MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
            ++N+ + V+   F          E ++RE + +  LE+++R L      +S + AS A  
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587

Query: 432  GDC 434
              C
Sbjct: 1588 AQC 1590



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)

Query: 1838 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1897
            SLE PT  P        EL  P+ + V   G     +S T   P+ ++++C        P
Sbjct: 1922 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1970

Query: 1898 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1953
            +  R W   K  S         P  +S +L +P +  H         P      GT+PK+
Sbjct: 1971 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2024

Query: 1954 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 1999
               G     RSP     L RQA     SLD              + PS       +    
Sbjct: 2025 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2079

Query: 2000 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2034
            S T +    R+       + PPAP PGP        P  R  L L               
Sbjct: 2080 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2139

Query: 2035 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2075
                    R L     + A             QR HS   S    G   H   DPS+   
Sbjct: 2140 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2196

Query: 2076 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2131
             GG   GG GS   + LS  S+T +  P    P  PP+PG+   R+  S+ S      P 
Sbjct: 2197 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2251

Query: 2132 AAALAHGLARSPS 2144
            A+     +A SPS
Sbjct: 2252 ASGPPDSMAASPS 2264



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 51/231 (22%), Positives = 82/231 (35%), Gaps = 63/231 (27%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
            F N G A++ +F+V T + W  IM   +       + YN     IYF+  ++   F ++N
Sbjct: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844

Query: 392  LCLVVIATQFSET-----KQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHIL 446
            + + V+     E+     ++ E    LE   + LS    +    P               
Sbjct: 1845 VVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSP--------------- 1889

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPG-----PHAKEPRHYQLCPQHSPLDATPH 501
                     L+  ++      GP++P   KPG      HA+   H+ L  +H  +   P 
Sbjct: 1890 --------FLWPGVE------GPDSPDSPKPGALHPAAHARSASHFSL--EHPTMQPHPT 1933

Query: 502  TLVQPIPATLA--------SDPASCPCCQHED------GRRPSGLGSTDSG 538
             L  P   T+         S P     C+H        G R  GL    SG
Sbjct: 1934 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSG 1984


>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
            isoform 15 [Homo sapiens]
          Length = 1555

 Score =  818 bits (2114), Expect = 0.0
 Identities = 478/872 (54%), Positives = 567/872 (65%), Gaps = 108/872 (12%)

Query: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714

Query: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766

Query: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826

Query: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886

Query: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005

Query: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055

Query: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102

Query: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158

Query: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202

Query: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262

Query: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322

Query: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382

Query: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442

Query: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1333
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQ
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86

Query: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146

Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206

Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266

Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318

Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378

Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438

Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470



 Score =  119 bits (298), Expect = 3e-26
 Identities = 80/313 (25%), Positives = 151/313 (48%), Gaps = 25/313 (7%)

Query: 1397 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDI 1456
            E  ++  Q  +  + R    +R R L      +  L ++   C T      +  S Y   
Sbjct: 691  EAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDT---FRKIVDSKYFGR 747

Query: 1457 FITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRW 1516
             I   I +N ++M +E++ QP  L  AL+  N +FT++F LE +LKL+ +G   + K+ +
Sbjct: 748  GIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPY 807

Query: 1517 NQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1576
            N  D  IV++SV  I  ++             + ++R  R+ RVLKL++    ++  L  
Sbjct: 808  NIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857

Query: 1577 VVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTL 1636
            +++ +  V    +L ML  FI++ LG+ LFG    + E   + +     F++   A +T+
Sbjct: 858  LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-ERDGDTLPDRKNFDSLLWAIVTV 916

Query: 1637 FQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMK 1696
            FQ+ T ++WN ++ +            ++S    + LYF++ +    +VL N++VA+L++
Sbjct: 917  FQILTQEDWNKVLYNG-----------MASTSSWAALYFIALMTFGNYVLFNLLVAILVE 965

Query: 1697 HLDDSNKEAQEDA 1709
                     +EDA
Sbjct: 966  GFQAEEISKREDA 978



 Score =  114 bits (285), Expect = 1e-24
 Identities = 81/296 (27%), Positives = 148/296 (50%), Gaps = 50/296 (16%)

Query: 1124 FRVLCQT---IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1180
            +R++C T   I+  K F   ++  I +N +++ +E  +     T    L +SN +FT++F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLF 786

Query: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240
              EM LK+    L +G   Y+++ +N+ DG +V +S+ +IV      GG   L VLR  R
Sbjct: 787  ALEMLLKL----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFR 837

Query: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300
            L+R L+ +R +   P L+  +  L+ ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 838  LMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894

Query: 1301 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1360
               DT                +  + NFD+L  A++++F + +++ W  ++YNG+     
Sbjct: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM----- 933

Query: 1361 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416
                  + + W  LYFI+ +   ++ + N+ V ++VE F       +AEE  +RE+
Sbjct: 934  -----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977



 Score =  112 bits (279), Expect = 5e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232

Query: 1293 FKG 1295
            + G
Sbjct: 233  WAG 235



 Score =  103 bits (257), Expect = 2e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325

Query: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 10/182 (5%)

Query: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYN-QPTSLETA-LKYCNYMFTTVFVLEA 1499
            RLL H + T    D  +  II LN +T+++E     P S E   L   NY+FT VF+ E 
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1500 VLKLVA----FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVL 1555
             +K+VA    FG + + +  WN LD  +VL+SV+ I +  +  +    +   ++R++R+L
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLL 1383

Query: 1556 RIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GK-LVCND 1613
            R  R L+++  A G++ +++T++ +L  +GN+ ++    F I+  LGV+LF GK  VC  
Sbjct: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG 1443

Query: 1614 EN 1615
            E+
Sbjct: 1444 ED 1445



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67

Query: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149

Query: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200

Query: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790

Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846

Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 399 TQF--SETKQRE 408
             F   E  +RE
Sbjct: 965 EGFQAEEISKRE 976



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395

Query: 828 EGF 830
             F
Sbjct: 396 TQF 398



 Score = 38.1 bits (87), Expect = 0.095
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score =  422 bits (1084), Expect = e-117
 Identities = 317/1166 (27%), Positives = 543/1166 (46%), Gaps = 107/1166 (9%)

Query: 584  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
            +W C  +W + +  L G+V   +    I + I+VNT+ M +EHH        +L+I N+V
Sbjct: 644  IWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIV 703

Query: 644  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
            FT  F  EM+ K+ AF  + Y +  +NIFD IIV +S+ E+     G LSVLR+FRLLRV
Sbjct: 704  FTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRV 763

Query: 704  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF-SLRTDTGDT 762
             KL +  P L   + ++  ++  +    ++L + +F+F+++G  + G  + + R +    
Sbjct: 764  FKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAP 823

Query: 763  VPD--RKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 819
              D  R +      + + VF+IL  E W   ++  M         + F+ +M  GN V+ 
Sbjct: 824  HEDWPRWHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGNLVVL 882

Query: 820  NLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGHL 879
            NL +A+L+  F A+   N +  ++D   +N++      +         LC          
Sbjct: 883  NLFIALLLNSFSAD---NLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF-------F 932

Query: 880  DPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSY 939
              S P            P P+     +P LV      SS       +   R  S    + 
Sbjct: 933  SRSCPF-----------PQPKA----EPELVVKLPLSSSKAENHIAANTARGSSGGLQAP 977

Query: 940  YGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHT 999
             GP    + + +  + W S+    P AE ES L      G    +    E  P+      
Sbjct: 978  RGPRDEHSDFIANPTVWVSV----PIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQL 1033

Query: 1000 PHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDC 1059
                    G HL  R              S DLA   P++G   +       PA G +D 
Sbjct: 1034 QQVERC--GDHLTPRSPG-------TGTSSEDLA---PSLGETWKDESVPQVPAEGVDDT 1081

Query: 1060 NGRMPSIA-----KDVFTKMGDRGDRGEDEEEIDYTLCFRVRKM--IDVYKPDWCEVRED 1112
            +    S       +++  K+ +  D  E+ ++     C R      +D  K  W      
Sbjct: 1082 SSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPW---DVG 1138

Query: 1113 WSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVS 1172
            W V         R  C  I+ H  F+  ++  I L+  ++A E   ++   T +  L  +
Sbjct: 1139 WQV---------RKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYT 1189

Query: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232
            + +FT IFV EM LK V+    +G + Y  ++W  LD  +V +S+I +   +        
Sbjct: 1190 DRVFTFIFVFEMLLKWVA----YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSE--- 1242

Query: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292
            +  ++ LR LR LRPLR +SR  G+++VV+ L+ ++  I N++L+C  F++IF I+GV L
Sbjct: 1243 VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1302

Query: 1293 FKGKFYHCLG--------VDTRNITNRSDCMAAN----YRWVHHKYNFDNLGQALMSLFV 1340
            F GKF+ C+         V    + N+SDC   N    + WV+ K NFDN+    ++L  
Sbjct: 1303 FAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQ 1362

Query: 1341 LASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFH 1400
            +A+  GW++IMY  +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++NF+
Sbjct: 1363 VATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFN 1422

Query: 1401 KCRQHQEAEEARRREE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFI 1458
            + ++    ++    EE  K    ++K   K  + P        +  +  + T    DI I
Sbjct: 1423 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITI 1482

Query: 1459 TFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKDRWN 1517
              +ICLN++TM +E  +Q       L   N  F  VF  E V+K+  F LR+ +F + WN
Sbjct: 1483 MVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKM--FALRQYYFTNGWN 1540

Query: 1518 QLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1577
              D  +V+LS+  +    I  +     +PT+ R++R+ RI R+L+L++ A G+R LL  +
Sbjct: 1541 VFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFAL 1600

Query: 1578 VQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLF 1637
            + +LP + N+GLL  L+ FIY+  G+  F  +         G+     F+ F  + L LF
Sbjct: 1601 MMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLF 1655

Query: 1638 QVSTGDNWNGIMKDTLR-----------DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVL 1686
            Q++T   W+G++   L            +       C S    V  ++F ++++ +  ++
Sbjct: 1656 QITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPA--VGIIFFTTYIIISFLIM 1713

Query: 1687 INVVVAVLMKHLDDSNKEAQEDAEMD 1712
            +N+ +AV++++ + + +E+ E    D
Sbjct: 1714 VNMYIAVILENFNVATEESTEPLSED 1739



 Score =  125 bits (314), Expect = 5e-28
 Identities = 85/343 (24%), Positives = 152/343 (44%), Gaps = 62/343 (18%)

Query: 69  RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
           R   IK+  + WF     + IL+NCV            C++ R  + +  +    + +  
Sbjct: 120 RRTAIKVSVHSWFSLFITVTILVNCV------------CMT-RTDLPEKIEYVFTVIYTF 166

Query: 129 EMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
           E ++K++A G    +  YL D WN LDF ++    V  ++DL+ I  S +RT RVLR LK
Sbjct: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGI--SGLRTFRVLRALK 224

Query: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEE---- 243
            ++ +P ++++V  L+ ++  L +V +L  F   +F ++G+QL+ G L+N+C   +    
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284

Query: 244 NFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDF 303
             T       P  Y  +     P +C    D+G                C     D Y  
Sbjct: 285 ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSG---------------HC----PDGY-- 323

Query: 304 GAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIM 363
                                +C   S NP     +FD+  +A++ +F+++T + W  + 
Sbjct: 324 ---------------------ICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY 362

Query: 364 YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQ 406
              +        I+F+L+I +GSF+++NL L V+   + E  Q
Sbjct: 363 QQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQ 405



 Score =  108 bits (270), Expect = 6e-23
 Identities = 85/355 (23%), Positives = 153/355 (43%), Gaps = 68/355 (19%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            +++LFSP N  R     +  H  F   +   I +NC+ +            E+I      
Sbjct: 109  ALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT------RTDLPEKI-----E 157

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y+FT I+  E  +K+++ G    E  YLR  WN LD  ++ ++ +   + L    G    
Sbjct: 158  YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---- 213

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
                 LR  R LR L+ +S  PGLK++V  LI S+K + ++ ++      +F ++G+QLF
Sbjct: 214  -----LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268

Query: 1294 KGKFYH-CLGVD-----TRNIT---------------------NRSD---------CMAA 1317
            KG   + C+  D     T N +                     N SD         C+  
Sbjct: 269  KGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKT 328

Query: 1318 NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFI 1377
            +     +  +FD+   A +SLF L ++D W  +           QQ +       +++F+
Sbjct: 329  SDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFV 378

Query: 1378 SFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRL 1432
              + + SF+++N+ + VV   + +  Q+Q   +    +EK+ +   +  RK Q +
Sbjct: 379  LVIFLGSFYLVNLILAVVTMAYEE--QNQATTDEIEAKEKKFQEALEMLRKEQEV 431



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 73/285 (25%), Positives = 133/285 (46%), Gaps = 36/285 (12%)

Query: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
            IV  + F+  IM+ I +N ++M +E  +Q EE T IL   N  F ++F  E ++K+ A  
Sbjct: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531

Query: 661  LFDYLRNPYNIFDSIIVIISIWEIVGQA----------DGGLSVLRTFRLLRVLKLVRFM 710
             + Y  N +N+FD I+V++SI  ++  A               V+R  R+ R+L+L+R  
Sbjct: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590

Query: 711  PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
              +R  L  LM ++  +    +LL L +FI+SI GM  F     +R + G  + D  NF 
Sbjct: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFP---HVRWEAG--IDDMFNFQ 1645

Query: 771  SLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS--------------------LYFVAL 810
            +   +++ +FQI T   W+ +L   + +  P+                      ++F   
Sbjct: 1646 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTY 1705

Query: 811  MTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
            +     ++ N+ +A+++E F    + +     ED      E ++K
Sbjct: 1706 IIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEK 1750



 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 79/245 (32%), Positives = 117/245 (47%), Gaps = 39/245 (15%)

Query: 29   RSPPSSPPGLEEPLD----GADPHVPHPDLAPIAFFCLRQTTSPRNW---------CIKM 75
            R  P     LEEP D    G   H P          C +  T+   W         C ++
Sbjct: 1099 RKIPELADDLEEPDDCFTEGCIRHCP----------CCKLDTTKSPWDVGWQVRKTCYRI 1148

Query: 76   VCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAMEMVLKM 134
            V + WFE   + +ILL+  +L       D        K L  + D +F F F  EM+LK 
Sbjct: 1149 VEHSWFESFIIFMILLSSGSLAFEDYYLDQ---KPTVKALLEYTDRVFTFIFVFEMLLKW 1205

Query: 135  VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKAIN 190
            VA   +G K Y  + W  LDF IV   ++  +  +   +    + A+RT+R LRPL+A++
Sbjct: 1206 VA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALS 1262

Query: 191  RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGD 250
            R   MR++V+ L+  +P + NVLL+C   + IF I+GV L+AG    RC    N+T  G+
Sbjct: 1263 RFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RCI---NYT-DGE 1317

Query: 251  VALPP 255
             +L P
Sbjct: 1318 FSLVP 1322



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 75/319 (23%), Positives = 147/319 (46%), Gaps = 29/319 (9%)

Query: 1406 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1465
            +E EE+ ++    L  L +K       P +      + ++  + T  + ++ IT  I +N
Sbjct: 622  EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL---KTILFGLVTDPFAELTITLCIVVN 678

Query: 1466 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1525
             + M++EH+    + E  L+  N +FT  F  E V K++AF    +F+ +WN  D  IV 
Sbjct: 679  TIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVT 738

Query: 1526 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1585
            +S+       +E+  A       + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 739  VSL-------LELGVA---KKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 788

Query: 1586 NLGLLFMLLFFIYAALGVELFGKLVCNDEN----PCEGMSRHATFENFGMAFLTLFQVST 1641
            NL ++  ++ F++A +G +L G+   N+      P E   R     +F  +FL +F++  
Sbjct: 789  NLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILC 847

Query: 1642 GDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
            G+ W   M   +      +  CL        + F++ ++    V++N+ +A+L+      
Sbjct: 848  GE-WIENMWACME--VGQKSICL--------ILFLTVMVLGNLVVLNLFIALLLNSFSAD 896

Query: 1702 NKEAQEDAEMDAELELEMA 1720
            N  A ED      L++ +A
Sbjct: 897  NLTAPEDDGEVNNLQVALA 915



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 81/339 (23%), Positives = 149/339 (43%), Gaps = 78/339 (23%)

Query: 580 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 639
           A  A+WL        R  ++  V S +F+  I + ILVN V M           T++ E 
Sbjct: 106 ATRALWLFSPFNLIRRTAIKVSVHS-WFSLFITVTILVNCVCM---------TRTDLPEK 155

Query: 640 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADG--GLS 693
              VFT ++  E ++K+ A G     F YLR+P+N  D  ++ ++    VG A    G+S
Sbjct: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAY---VGTAIDLRGIS 212

Query: 694 VLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF 753
            LRTFR+LR LK V  +P L+  +  L+ ++  +A   +L +  + +F+++G+ +F    
Sbjct: 213 GLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272

Query: 754 SLRTDTGDTV------------PD-----RKNFDSLL----------------------- 773
             +    D              PD     R   D LL                       
Sbjct: 273 KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332

Query: 774 -----------WAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLL 822
                      WA +++F+++TQ+ W  +    + ++     ++FV ++  G++ L NL+
Sbjct: 333 DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLI 392

Query: 823 VAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLD 861
           +A++   ++   + N++ +DE ++        K QE L+
Sbjct: 393 LAVVTMAYE---EQNQATTDEIEAKEK-----KFQEALE 423



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 65/313 (20%), Positives = 134/313 (42%), Gaps = 86/313 (27%)

Query: 1453 YLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLR--- 1509
            +  +FIT  I +N V M+    + P  +E       Y+FT ++  EA++K++A G     
Sbjct: 131  WFSLFITVTILVNCVCMT--RTDLPEKIE-------YVFTVIYTFEALIKILARGFCLNE 181

Query: 1510 -RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMAT 1568
              + +D WN LD +++ L+ +G  ++   I+            +R  R+ R LK + +  
Sbjct: 182  FTYLRDPWNWLDFSVITLAYVGTAIDLRGISG-----------LRTFRVLRALKTVSVIP 230

Query: 1569 GMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-----GKLVCNDE--NPCEGMS 1621
            G++ ++  ++ ++ ++ ++ +L +    ++A +G++LF      K V ND   N     S
Sbjct: 231  GLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYS 290

Query: 1622 RH--------------------------------------------ATFENFGMAFLTLF 1637
             H                                             +F++F  AFL+LF
Sbjct: 291  SHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLF 350

Query: 1638 QVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKH 1697
            ++ T D+W  + + TLR               +  ++FV  +    F L+N+++AV+   
Sbjct: 351  RLMTQDSWERLYQQTLRTSGK-----------IYMIFFVLVIFLGSFYLVNLILAVVTMA 399

Query: 1698 LDDSNKEAQEDAE 1710
             ++ N+   ++ E
Sbjct: 400  YEEQNQATTDEIE 412



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 44/164 (26%), Positives = 82/164 (50%), Gaps = 10/164 (6%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIF-IFFAMEMVLK 133
           +V +P+ E    L I++N + + M     +   +S   + +    + +F IFF  EMV K
Sbjct: 661 LVTDPFAELTITLCIVVNTIFMAM-----EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFK 715

Query: 134 MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVP 193
           ++A   F    Y    WN  D  IV   ++E  +  +  +LS +R+ R+LR  K     P
Sbjct: 716 IIA---FDPYYYFQKKWNIFDCIIVTVSLLELGVAKKG-SLSVLRSFRLLRVFKLAKSWP 771

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRN 237
           ++  L+ ++ +++  LGN+ ++   + F+F ++G QL     RN
Sbjct: 772 TLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRN 815



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 30/98 (30%), Positives = 58/98 (59%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
            +NFDN+   ++ + QV T +GW++IMY  +D+           + Y ++YF++ II G F
Sbjct: 1348 VNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGF 1407

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1408 FTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1445



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 49/157 (31%), Positives = 76/157 (48%), Gaps = 17/157 (10%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN +T  M    DD     ++ KIL   + F    F  E V+KM AL   
Sbjct: 1478 FDITIMVLICLNMIT--MMVETDDQS--EEKTKILGKINQFFVAVFTGECVMKMFAL--- 1530

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVE--YSLDLQNIN-------LSAIRTVRVLRPLKAINR 191
             ++ Y  + WN  DF +V+  +    +S  L+++           IR  R+ R L+ I  
Sbjct: 1531 -RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRA 1589

Query: 192  VPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 228
               +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 1590 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score =  354 bits (908), Expect = 6e-97
 Identities = 196/594 (32%), Positives = 337/594 (56%), Gaps = 34/594 (5%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C  I+ H  F+  ++  I L+   +  E   +E     +  L  ++ IFT IF+ EM
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+ G  FG+  Y  S+W  LD  +V VS+  ++  +           L+  R LR 
Sbjct: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302
            LRPLR +S+  G+K+VV  LI ++  I N++L+C  F+++F ILGV  F GKF  C+   
Sbjct: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211

Query: 1303 ---VDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
               ++   ITN+S C + N+ W++ K NFDN+G A ++L  +A+  GW++I+Y  +D+  
Sbjct: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271

Query: 1360 VDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--K 1417
             +QQP    N    +YF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE  K
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331

Query: 1418 RLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQP 1477
                ++K   K  + P        + L+  + TS   DI I  +I LN+++M  E YNQP
Sbjct: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391

Query: 1478 TSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKDRWNQLDLAIVLLSVMGITLEEI 1536
             ++++ L + N++F  +F LE ++K+  F LR+ +F + WN  D  +VLLS++   +  +
Sbjct: 1392 KAMKSILDHLNWVFVVIFTLECLIKI--FALRQYYFTNGWNLFDCVVVLLSIVSTMISTL 1449

Query: 1537 EINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 1596
            E    +P  PT+ RI+R+ RI R+L+L++ A G+R LL  ++ +LP + N+GLL  L+ F
Sbjct: 1450 ENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1509

Query: 1597 IYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR-- 1654
            IYA LG+  F K+     NP  G+     F+ F  + L LFQ+ST   W+ ++   LR  
Sbjct: 1510 IYAILGMNWFSKV-----NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSK 1564

Query: 1655 -DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707
              C     +C   L  ++  YFVS+++ +  +++N+ +AV++++ + + +E+++
Sbjct: 1565 ESCNSSSENC--HLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616



 Score =  211 bits (536), Expect = 8e-54
 Identities = 203/803 (25%), Positives = 347/803 (43%), Gaps = 120/803 (14%)

Query: 58  AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
           A F      S R+  I++  +  F    +  +++NCV +    P  + +  S+   I + 
Sbjct: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKNSN--SNNTDIAEC 164

Query: 118 FDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
               I+IF   E ++K++A G I  +  +L D WN LD  ++   +V Y   +  I L  
Sbjct: 165 VFTGIYIF---EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLP 220

Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
           +RT RV R LKAI+ V  ++++V  LL ++  L NV++L FF   IF ++G QL+ G L 
Sbjct: 221 LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLN 280

Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
            +C   +   I    A    ++ +E+     +C +   N                 C + 
Sbjct: 281 LKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNS---------------ACSIQ 325

Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITL 356
            +                           C+    NP     NFDN G++++ +F+++T 
Sbjct: 326 YE---------------------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQ 358

Query: 357 EGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQR 416
           + W ++    +     Y+  +FI++I +GSF++INL L V+   + E             
Sbjct: 359 DSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE------------- 405

Query: 417 QRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAK 476
                +  VA+  E     E++FQ    +L K ++ AL      +S   +L      P K
Sbjct: 406 ----QNKNVAAEIE---AKEKMFQEAQQLL-KEEKEALVAMGIDRSSLTSLETSYFTPKK 457

Query: 477 PGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTD 536
                 + R      + S  D  P            SD  S   CQ    ++P  L  T 
Sbjct: 458 RKLFGNKKRK-SFFLRESGKDQPP-----------GSD--SDEDCQ----KKPQLLEQT- 498

Query: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGD------- 589
              +      S    DE      R     A S L    +E+E++      CG+       
Sbjct: 499 ---KRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYL 555

Query: 590 VWR------ETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
           VW         +  LR ++   +    I + I++NTV + +EHH+       +L I N+V
Sbjct: 556 VWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLV 615

Query: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG--QADGGLSVLRTFRLL 701
           FTS+F  EM LK+ A   + Y R  +NIFDSI+ ++S  +++           LR+FR+L
Sbjct: 616 FTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVL 675

Query: 702 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS------L 755
           RV KL +  P L   + ++  ++  + +  ++L++ IFIFS++GM +FG  F+      L
Sbjct: 676 RVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKL 735

Query: 756 RTDTGDTVPDRKNF--DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL---YFVAL 810
              TG TV   +++       + + VF+IL  E W   ++  M   +  +SL    F+ +
Sbjct: 736 CNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILI 794

Query: 811 MTFGNYVLFNLLVAILVEGFQAE 833
              G  V+ NL +A+L+  F  E
Sbjct: 795 TVIGKLVVLNLFIALLLNSFSNE 817



 Score =  119 bits (299), Expect = 2e-26
 Identities = 84/349 (24%), Positives = 165/349 (47%), Gaps = 55/349 (15%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++++F P N  R L   +  H LF   ++  + +NC+ +A   P   + S       ++ 
Sbjct: 108  ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG-PAKNSNSNNT---DIAE 163

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
             +FT I++ E  +K+++ G    E ++LR  WN LD  ++ ++I+  +  +      K+L
Sbjct: 164  CVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLL 219

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
              LR  R+ R L+ + V+SR   LK++V  L+ S+K + N++++      IF ++G QLF
Sbjct: 220  P-LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275

Query: 1294 KGKF-YHCLGVDTRNITN------------------------RSDCMAANYRWVHHKY-- 1326
             G     C+  D +NI+N                         +   +  Y   H K   
Sbjct: 276  MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335

Query: 1327 -----NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL 1381
                 NFDN G + +++F L ++D W  +           QQ +     + + +FI  + 
Sbjct: 336  DYNYTNFDNFGWSFLAMFRLMTQDSWEKLY----------QQTLRTTGLYSVFFFIVVIF 385

Query: 1382 IVSFFVLNMFVGVVVENFHKCRQHQEAE-EARRREEKRLRRLEKKRRKA 1429
            + SF+++N+ + VV   + +  ++  AE EA+ +  +  ++L K+ ++A
Sbjct: 386  LGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEA 434



 Score =  105 bits (262), Expect = 5e-22
 Identities = 69/281 (24%), Positives = 138/281 (49%), Gaps = 33/281 (11%)

Query: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503
            ++ ++ T  + ++ IT  I +N V +++EH+    S E  L   N +FT++F+ E  LK+
Sbjct: 569  VLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI 628

Query: 1504 VAFGLRRFFKDRWNQLDLAIVLLS---VMGITLEEIEINAALPINPTIIRIMRVLRIARV 1560
            +A     +F+  WN  D  + LLS   VM   L++     + P        +R  R+ RV
Sbjct: 629  IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQK----RSWP-------FLRSFRVLRV 677

Query: 1561 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK--------LVCN 1612
             KL K    +  L+  +  ++  +G+L ++ +++ FI++ +G++LFG+         +CN
Sbjct: 678  FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCN 737

Query: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672
               P     RH    +F  +FL +F++  G+ W   M + +++       C+        
Sbjct: 738  PTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCV-------- 788

Query: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDA 1713
            + F+   +  + V++N+ +A+L+     SN+E   + E +A
Sbjct: 789  IVFILITVIGKLVVLNLFIALLLNSF--SNEERNGNLEGEA 827



 Score =  103 bits (258), Expect = 1e-21
 Identities = 74/277 (26%), Positives = 137/277 (49%), Gaps = 28/277 (10%)

Query: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
            IV S+ F+  I+  I++N +SM  E + QP+ + +IL+  N VF  +F LE ++K+ A  
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421

Query: 661  LFDYLRNPYNIFDSIIVIISI----------WEIVGQADGGLSVLRTFRLLRVLKLVRFM 710
             + Y  N +N+FD ++V++SI           E +        ++R  R+ R+L+LVR  
Sbjct: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480

Query: 711  PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
              +R  L  LM ++ ++    +LL L +FI++ILGM+ F      + +    + D  NF 
Sbjct: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFK 1535

Query: 771  SLLWAIVTVFQILTQEDWNVVLYNGMASTSPW------------ASLYFVALMTFGNYVL 818
            +   +++ +FQI T   W+ +L   + S                A+ YFV+ +     ++
Sbjct: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIV 1595

Query: 819  FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
             N+ +A+++E F    + +     ED      E ++K
Sbjct: 1596 VNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEK 1632



 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 40/279 (14%)

Query: 590  VWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFTSM 647
            +W   R     IV   +F   I+  IL+++ ++  E  H E   ++  +L   +++FT +
Sbjct: 1041 IWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHI 1100

Query: 648  FALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLV 707
            F LEM+LK  AFG   Y  + +   D IIVI+S+  ++      L  L++FR LR L+ +
Sbjct: 1101 FILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPL 1155

Query: 708  RFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTV- 763
            R +       VV   L+  +  +    ++ ++F  +F ILG++ F  KF    +  D+V 
Sbjct: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVI 1215

Query: 764  -------------------PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----- 799
                                 + NFD++  A + + Q+ T + W  ++Y  + ST     
Sbjct: 1216 NYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQ 1275

Query: 800  -----SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 833
                 +    +YFV  + FG++   NL + ++++ F  +
Sbjct: 1276 PEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 14/168 (8%)

Query: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFD--DFIFI-F 125
            R  C ++V + WFE   + VILL+   L      +D+  L ++ KI ++ +  D IF   
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVH-LENQPKIQELLNCTDIIFTHI 1100

Query: 126  FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRP 185
            F +EMVLK VA G FGK  Y    W  LDF IV+  +      +  + L + RT+R LRP
Sbjct: 1101 FILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTL---INLMELKSFRTLRALRP 1154

Query: 186  LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            L+A+++   M+++VN L+  +P + NVLL+C   + +F I+GV  ++G
Sbjct: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 71/327 (21%), Positives = 138/327 (42%), Gaps = 60/327 (18%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           F+  I+  +++N V M     +     +N  +I   VFT ++  E ++K+ A G     F
Sbjct: 131 FSMFIIGTVIINCVFMATGPAKNSN--SNNTDIAECVFTGIYIFEALIKILARGFILDEF 188

Query: 663 DYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMK 722
            +LR+P+N  DSI++ I+I   +      L  LRTFR+ R LK +  +  L+  +  L++
Sbjct: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248

Query: 723 TMDNVATFCMLLMLFIFIFSILGMHIF-----------GCKFSLRTDTGDTVPDRK---- 767
           ++  +    +L    + IF+++G  +F            CK     +  D   ++K    
Sbjct: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSP 308

Query: 768 --------------------------------NFDSLLWAIVTVFQILTQEDWNVVLYNG 795
                                           NFD+  W+ + +F+++TQ+ W  +    
Sbjct: 309 EFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQT 368

Query: 796 MASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQ-------AEGDANRSYSDEDQSSS 848
           + +T  ++  +F+ ++  G++ L NL +A++   ++       AE +A      E Q   
Sbjct: 369 LRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLL 428

Query: 849 NIEEFDKLQEGLDSSGDPKLCPIPMTP 875
             E+   +  G+D S    L     TP
Sbjct: 429 KEEKEALVAMGIDRSSLTSLETSYFTP 455



 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 68/321 (21%), Positives = 142/321 (44%), Gaps = 37/321 (11%)

Query: 1129 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV 1188
            +T++     +  +   I +N + +A+E  ++EA S E++ L + N +FT+IF+ EM LK+
Sbjct: 571  RTVMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKI 628

Query: 1189 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL 1248
            ++L  Y     Y R  WN+ D  +  +S  D++  +        L   RVLR+ +  +  
Sbjct: 629  IALDPYH----YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW 684

Query: 1249 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI 1308
                  P L  +++ + +S+  +G++ ++      IF ++G+QLF   F      +++  
Sbjct: 685  ------PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSF------NSQKS 732

Query: 1309 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH 1368
                +        + H +  D     L+   +L  +  W+  M+  +       Q     
Sbjct: 733  PKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECM-------QEANAS 783

Query: 1369 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRK 1428
            +   ++ FI   +I    VLN+F+ +++ +F    ++   E   R+ + +L  L++ RR 
Sbjct: 784  SSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL-ALDRFRR- 841

Query: 1429 AQRLPYYATYCHTRLLIHSMC 1449
                     +C  R  +   C
Sbjct: 842  --------AFCFVRHTLEHFC 854



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 68/324 (20%), Positives = 136/324 (41%), Gaps = 87/324 (26%)

Query: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1501
            R+ +HS+       +FI   + +N V M+        S  T +  C  +FT +++ EA++
Sbjct: 124  RVSVHSL-----FSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYIFEALI 176

Query: 1502 KLVAFGLR----RFFKDRWNQLDLAIVLLSVM----GITLEEIEINAALPINPTIIRIMR 1553
            K++A G       F +D WN LD  ++ ++++    GIT++       LP+        R
Sbjct: 177  KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK------LLPL--------R 222

Query: 1554 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------- 1606
              R+ R LK + + + ++ ++  +++++ ++ N+ +L      I+A +G +LF       
Sbjct: 223  TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282

Query: 1607 -----------------------------------GKLVCNDENPCEGMS-----RHATF 1626
                                               G   C+ +  C+         +  F
Sbjct: 283  CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342

Query: 1627 ENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVL 1686
            +NFG +FL +F++ T D+W  + + TLR           +    S  +F+  +    F L
Sbjct: 343  DNFGWSFLAMFRLMTQDSWEKLYQQTLR-----------TTGLYSVFFFIVVIFLGSFYL 391

Query: 1687 INVVVAVLMKHLDDSNKEAQEDAE 1710
            IN+ +AV+    ++ NK    + E
Sbjct: 392  INLTLAVVTMAYEEQNKNVAAEIE 415



 Score = 68.2 bits (165), Expect = 9e-11
 Identities = 36/128 (28%), Positives = 72/128 (56%), Gaps = 15/128 (11%)

Query: 310  LNASGLCVNWNRYYNV--CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367
            +N +   +N+    N   C +G+ +     +NFDN+G A++ + QV T +GW++I+Y  +
Sbjct: 1208 INGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAV 1267

Query: 368  DA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLE 414
            D+           +   +IYF++ II GSFF +NL + VI   F++ +++   +   M E
Sbjct: 1268 DSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTE 1327

Query: 415  QRQRYLSS 422
            ++++Y ++
Sbjct: 1328 EQKKYYNA 1335



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 42/174 (24%), Positives = 82/174 (47%), Gaps = 21/174 (12%)

Query: 68   PRNWC----IKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIF 123
            P N C      +V +  F+ + + +I+LN +++ M +  +    +     IL   +    
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISM-MAESYNQPKAMKS---ILDHLNWVFV 1406

Query: 124  IFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-LQNIN--------L 174
            + F +E ++K+ AL    ++ Y  + WN  D  +V+  +V   +  L+N           
Sbjct: 1407 VIFTLECLIKIFAL----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLF 1462

Query: 175  SAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 228
              +R  R+ R L+ +     +R L+  L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 1463 RIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516



 Score = 35.8 bits (81), Expect = 0.47
 Identities = 22/76 (28%), Positives = 44/76 (57%), Gaps = 5/76 (6%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 401
           ++++V+F+++  E W+E M+  M   +A S    I FIL+ ++G   ++NL + ++   F
Sbjct: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814

Query: 402 SETKQREHRLMLEQRQ 417
           S  ++R   L  E R+
Sbjct: 815 S-NEERNGNLEGEARK 829


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score =  343 bits (881), Expect = 8e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1207 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 1305 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1356
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 1357 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439

Query: 1417 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499

Query: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1557

Query: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616

Query: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1617 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671

Query: 1655 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1704
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731

Query: 1705 AQED-AEMDAELELEMAHGLGP 1725
            + E  +E D E+  E+     P
Sbjct: 1732 SAEPLSEDDFEMFYEVWEKFDP 1753



 Score =  150 bits (380), Expect = 1e-35
 Identities = 85/283 (30%), Positives = 161/283 (56%), Gaps = 10/283 (3%)

Query: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
           +W C D W + +  +  IV   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 690 IWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV 749

Query: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
           FT +F  EM+LK+ A   + Y +  +NIFD IIV +S+ E+      GLSVLR+FRLLRV
Sbjct: 750 FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRV 809

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 760
            KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +  
Sbjct: 810 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 869

Query: 761 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 819
            T+P R + +    + + VF++L  E W   +++ M  +      + F+ +M  GN V+ 
Sbjct: 870 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVL 927

Query: 820 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861
           NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 928 NLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 967



 Score =  128 bits (321), Expect = 7e-29
 Identities = 106/411 (25%), Positives = 185/411 (45%), Gaps = 53/411 (12%)

Query: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129

Query: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179

Query: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199
            +   +L D WN LDF +++   V   + L N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNV--SALRTFRVLRALKTISVIPGLKTIV 237

Query: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286

Query: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343

Query: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403

Query: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ ++
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454



 Score =  109 bits (273), Expect = 3e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762

Query: 1504 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1563
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 812

Query: 1564 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1619
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872

Query: 1620 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1677
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 917

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1708
             ++    V++N+ +A+L+      N  A +D
Sbjct: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 948



 Score =  107 bits (266), Expect = 2e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1520 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 588  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 645
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199

Query: 646  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 700
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259

Query: 701  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 756
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 757  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 797
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 798  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 847
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1436

Query: 848  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
            +  EE  K    +   G  K   PIP   N
Sbjct: 1437 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1464



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 91/373 (24%), Positives = 162/373 (43%), Gaps = 75/373 (20%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   VSL         
Sbjct: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSL--------- 209

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269

Query: 1294 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1341
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329

Query: 1342 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1374
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387

Query: 1375 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1417
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447

Query: 1418 RLRRLEKKRRKAQ 1430
             L +L+K++ +AQ
Sbjct: 448  MLEQLKKQQEEAQ 460



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 1127 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1185
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759

Query: 1186 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1245
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 760  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 807

Query: 1246 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1305
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 863

Query: 1306 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 864  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907

Query: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1203

Query: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 1204 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260

Query: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533

Query: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592

Query: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1647

Query: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 1648 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1707

Query: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 1708 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1750



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183

Query: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D S+IV+  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVSL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 722 KTMDNVATFCMLLMLFIFIFSILGMHIF 749
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1446



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
           +V +P+ +    + I+LN + + M    +          +L V +      F  EMVLK+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762

Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
           +A+  +    Y  + WN  D  IV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 763 IAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWP 817

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 818 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDCTL 872

Query: 254 PPYY 257
           P ++
Sbjct: 873 PRWH 876



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 1479 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1531

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590

Query: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424

Query: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411

Query: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1716
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446



 Score = 35.8 bits (81), Expect = 0.47
 Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score =  343 bits (881), Expect = 8e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1207 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 1305 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1356
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 1357 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439

Query: 1417 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499

Query: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1557

Query: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616

Query: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1617 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671

Query: 1655 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1704
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731

Query: 1705 AQED-AEMDAELELEMAHGLGP 1725
            + E  +E D E+  E+     P
Sbjct: 1732 SAEPLSEDDFEMFYEVWEKFDP 1753



 Score =  150 bits (380), Expect = 1e-35
 Identities = 85/283 (30%), Positives = 161/283 (56%), Gaps = 10/283 (3%)

Query: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
           +W C D W + +  +  IV   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 690 IWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV 749

Query: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
           FT +F  EM+LK+ A   + Y +  +NIFD IIV +S+ E+      GLSVLR+FRLLRV
Sbjct: 750 FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRV 809

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 760
            KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +  
Sbjct: 810 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 869

Query: 761 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 819
            T+P R + +    + + VF++L  E W   +++ M  +      + F+ +M  GN V+ 
Sbjct: 870 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVL 927

Query: 820 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861
           NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 928 NLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 967



 Score =  130 bits (327), Expect = 1e-29
 Identities = 107/411 (26%), Positives = 186/411 (45%), Gaps = 53/411 (12%)

Query: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129

Query: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179

Query: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199
            +   +L D WN LDF +++   V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237

Query: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286

Query: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343

Query: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403

Query: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ ++
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454



 Score =  109 bits (273), Expect = 3e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762

Query: 1504 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1563
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 763  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 812

Query: 1564 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1619
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 813  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872

Query: 1620 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1677
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 873  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 917

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1708
             ++    V++N+ +A+L+      N  A +D
Sbjct: 918  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 948



 Score =  107 bits (266), Expect = 2e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1520 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 588  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 645
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199

Query: 646  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 700
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259

Query: 701  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 756
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 757  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 797
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 798  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 847
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1436

Query: 848  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
            +  EE  K    +   G  K   PIP   N
Sbjct: 1437 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1464



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   V L         
Sbjct: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269

Query: 1294 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1341
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329

Query: 1342 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1374
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387

Query: 1375 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1417
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447

Query: 1418 RLRRLEKKRRKAQ 1430
             L +L+K++ +AQ
Sbjct: 448  MLEQLKKQQEEAQ 460



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 1127 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1185
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759

Query: 1186 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1245
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 760  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 807

Query: 1246 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1305
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 863

Query: 1306 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 864  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907

Query: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1203

Query: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 1204 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260

Query: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533

Query: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592

Query: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1647

Query: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 1648 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1707

Query: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 1708 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1750



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183

Query: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D S+IV+  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 722 KTMDNVATFCMLLMLFIFIFSILGMHIF 749
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1446



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
           +V +P+ +    + I+LN + + M    +          +L V +      F  EMVLK+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762

Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
           +A+  +    Y  + WN  D  IV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 763 IAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWP 817

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 818 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDCTL 872

Query: 254 PPYY 257
           P ++
Sbjct: 873 PRWH 876



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 1479 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1531

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590

Query: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424

Query: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411

Query: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1716
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446



 Score = 35.8 bits (81), Expect = 0.47
 Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score =  343 bits (881), Expect = 8e-94
 Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C +I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+    +G Q Y  ++W  LD  +V VS++ +V   A+A G   LG ++ LR LR 
Sbjct: 1256 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+ + 
Sbjct: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368

Query: 1305 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1356
            T N      + N SDC A     RW + K NFDN+G   ++L  +A+  GW++IMY  +D
Sbjct: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428

Query: 1357 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE
Sbjct: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488

Query: 1417 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1474
              K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +E  
Sbjct: 1489 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1548

Query: 1475 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1534
            +Q   +   L   N +F  +F  E VLKLV+     +F   WN  D  +V+LS++G+ L 
Sbjct: 1549 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1606

Query: 1535 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1594
              E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL  L+
Sbjct: 1607 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1665

Query: 1595 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1654
             FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++   L 
Sbjct: 1666 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1720

Query: 1655 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1704
                DC  D     SS++       V   +FVS+++ +  V++N+ +AV++++   + +E
Sbjct: 1721 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1780

Query: 1705 AQED-AEMDAELELEMAHGLGP 1725
            + E  +E D E+  E+     P
Sbjct: 1781 SAEPLSEDDFEMFYEVWEKFDP 1802



 Score =  151 bits (381), Expect = 8e-36
 Identities = 115/432 (26%), Positives = 201/432 (46%), Gaps = 48/432 (11%)

Query: 447  RKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQP 506
            R  +RR   + QA  S R    P  PA  K                HS +D      +  
Sbjct: 616  RHGERRNSNVSQASMSSRMV--PGLPANGK---------------MHSTVDCNGVVSLVG 658

Query: 507  IPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGA 566
             P+ L S     P         P G  +    ++   S      E   D  G + +   A
Sbjct: 659  GPSALTSPTGQLP---------PEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA 709

Query: 567  SSELGKEEEEEEQADGA------------VWLCGDVWRETRAKLRGIVDSKYFNRGIMMA 614
            S      EE EE                 +W C D W + +  +  IV   + +  I + 
Sbjct: 710  SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC 769

Query: 615  ILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDS 674
            I++NT+ M +EH+   E+ +++L + N+VFT +F  EM+LK+ A   + Y +  +NIFD 
Sbjct: 770  IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG 829

Query: 675  IIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLL 734
            IIV +S+ E+      GLSVLR+FRLLRV KL +  P L   + ++  ++  +    ++L
Sbjct: 830  IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 889

Query: 735  MLFIFIFSILGMHIFGCKFS---LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVV 791
             + +FIF+++GM +FG  +     + +   T+P R + +    + + VF++L  E W   
Sbjct: 890  AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIET 947

Query: 792  LYNGM-ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNI 850
            +++ M  +      + F+ +M  GN V+ NL +A+L+  F ++   N + +D+D   +N+
Sbjct: 948  MWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD---NLAATDDDNEMNNL 1004

Query: 851  E-EFDKLQEGLD 861
            +    ++Q+G+D
Sbjct: 1005 QIAVGRMQKGID 1016



 Score =  130 bits (327), Expect = 1e-29
 Identities = 107/411 (26%), Positives = 186/411 (45%), Gaps = 53/411 (12%)

Query: 35  PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80
           P  + EPL+  DP+  +                 A  A + L      R   IK++ +  
Sbjct: 70  PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129

Query: 81  FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
           F  + M  IL NCV + +  P        D  K ++     I+ F   E ++K++A G  
Sbjct: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179

Query: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199
            +   +L D WN LDF +++   V   +DL N+  SA+RT RVLR LK I+ +P ++ +V
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237

Query: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259
             L+ ++  L +V++L  F   +F +IG+QL+ G LRN+C           +  PP    
Sbjct: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286

Query: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317
            E +   +       NG      +     +     +  D  +    G++D  L  +G   
Sbjct: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343

Query: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377
                  +C     NP+ G  +FD   +A++ +F+++T + W  +    + A      I+
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403

Query: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418
           F+L+I +GSF+++NL L V+A  +          +E K+ E + MLEQ ++
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454



 Score =  109 bits (273), Expect = 3e-23
 Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)

Query: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1503
            L++ +    ++D+ IT  I LN + M++EHY       + L   N +FT +F  E VLK+
Sbjct: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811

Query: 1504 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1563
            +A     +F++ WN  D  IV LS+M + L  +E           + ++R  R+ RV KL
Sbjct: 812  IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 861

Query: 1564 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1619
             K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFGK     VC   + C  
Sbjct: 862  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921

Query: 1620 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1677
               H    +F  +FL +F+V  G+ W     +T+ DC     +  CL        + F+ 
Sbjct: 922  PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 966

Query: 1678 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1708
             ++    V++N+ +A+L+      N  A +D
Sbjct: 967  VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 997



 Score =  107 bits (266), Expect = 2e-22
 Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+F+ +    +  ++FD  ++  I LN +T+ +E    + G    + L+  N +F  +
Sbjct: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK+VSL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1569 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
                                  +   +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P T H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774



 Score =  100 bits (250), Expect = 1e-20
 Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)

Query: 588  GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 645
            G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +LE  + VFT
Sbjct: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248

Query: 646  SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 700
             +F LEM+LK  A+G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308

Query: 701  LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 756
            LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  KF    ++ 
Sbjct: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368

Query: 757  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 797
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428

Query: 798  S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 847
            S           + +  LYFV  + FG++   NL + ++++ F  +    + +  +D   
Sbjct: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1485

Query: 848  SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
            +  EE  K    +   G  K   PIP   N
Sbjct: 1486 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1513



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ +P N  R +   I+ H LF  +++  I  NC+ + L  P     + E        
Sbjct: 107  ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++ ++ +   V L         
Sbjct: 159  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 210  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269

Query: 1294 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1341
             G   + CL         +T   +  +  M +N  +V+     +N+ D +G       + 
Sbjct: 270  MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329

Query: 1342 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1374
              KD    +  NG DA    +  +      NP           W  L             
Sbjct: 330  GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387

Query: 1375 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1417
                        Y I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++
Sbjct: 388  LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447

Query: 1418 RLRRLEKKRRKAQ 1430
             L +L+K++ +AQ
Sbjct: 448  MLEQLKKQQEEAQ 460



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)

Query: 1127 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1185
            L   I+     D  +   I LN + +A+E  P  E  S+    LTV N +FT IF  EM 
Sbjct: 752  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 808

Query: 1186 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1245
            LK++++  Y+    Y +  WN+ DG +V +S++++ +S            L VLR  R L
Sbjct: 809  LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 856

Query: 1246 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1305
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   +  C+    
Sbjct: 857  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 912

Query: 1306 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1365
                   DC     RW  H  +F      L+   VL  +  W+  M++ ++         
Sbjct: 913  --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 956

Query: 1366 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 957  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)

Query: 69   RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127
            R  C  +V + WFE   + +ILL+   L       +        K +  + D +F + F 
Sbjct: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1252

Query: 128  MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183
            +EM+LK VA   +G + Y  + W  LDF IV   +  +V  +L    +  + ++RT+R L
Sbjct: 1253 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309

Query: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            RPL+A++R   MR++VN L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359



 Score = 89.0 bits (219), Expect = 5e-17
 Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)

Query: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
            V  + F+  IM+ I +N V+M +E  +Q + +T +L   N+VF  +F  E +LKL +   
Sbjct: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582

Query: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641

Query: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1696

Query: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 1697 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1756

Query: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
                V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 1757 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1799



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           F+  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183

Query: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D S+IV+  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241

Query: 722 KTMDNVATFCMLLMLFIFIFSILGMHIF 749
           +++  ++   +L +  + +F+++G+ +F
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
           +V +P+ +    + I+LN + + M    +          +L V +      F  EMVLK+
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811

Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
           +A+  +    Y  + WN  D  IV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 812 IAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWP 866

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 867 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDCTL 921

Query: 254 PPYY 257
           P ++
Sbjct: 922 PRWH 925



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN VT+ M +  D    ++    +L   +    + F  E VLK+V+L   
Sbjct: 1528 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1580

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
             +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639

Query: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424

Query: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457



 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)

Query: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 363  YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411

Query: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1716
             F L+N+++AV+    ++ N+   E+AE  +AE +
Sbjct: 412  SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446



 Score = 35.8 bits (81), Expect = 0.47
 Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score =  342 bits (877), Expect = 2e-93
 Identities = 209/625 (33%), Positives = 345/625 (55%), Gaps = 39/625 (6%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +I L  ++ IFT IF+ EM
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK ++    +G + Y  ++W  LD  +V VS++ +V   A+  G   LG ++ LR LR 
Sbjct: 1231 LLKWIA----YGYKTYFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1304
            LRPLR +SR  G+++VV  LI ++  I N++L+C  F++IF I+GV LF GKFY C+   
Sbjct: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343

Query: 1305 ------TRNITNRSDCMAA-----NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353
                     + NRS+C A      N RW + K NFDN+G   +SL  +A+  GW  IMY 
Sbjct: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403

Query: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413
             +D+V VD+QP   ++ +M +YF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463

Query: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471
             EE  K    ++K   K  + P        +  I  + T+   DI I  +ICLN+VTM +
Sbjct: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523

Query: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531
            E   Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V++S++G+
Sbjct: 1524 EKEGQSQHMTEVLYWINVVFIILFTGECVLKLISL-RHYYFTVGWNIFDFVVVIISIVGM 1582

Query: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591
             L   ++     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1583 FL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLL 1640

Query: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651
             L+ FIYA  G+  F  +   D     G++    FE FG + + LFQ++T   W+G++  
Sbjct: 1641 FLVMFIYAIFGMSNFAYVKKED-----GINDMFNFETFGNSMICLFQITTSAGWDGLLAP 1695

Query: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             L     DC   +    SS++       V   YFVS+++ +  V++N+ +AV++++   +
Sbjct: 1696 ILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVA 1755

Query: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725
             +E+ E  +E D E+  E+     P
Sbjct: 1756 TEESTEPLSEDDFEMFYEVWEKFDP 1780



 Score =  151 bits (381), Expect = 8e-36
 Identities = 86/272 (31%), Positives = 155/272 (56%), Gaps = 9/272 (3%)

Query: 584 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
           +W C   W + +  +  IV   + +  I + I++NT+ M +EHH   EE  N+L I N+V
Sbjct: 712 IWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771

Query: 644 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
           FT +FA EM+LKL A   ++Y +  +NIFDS+IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 772 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRV 831

Query: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 760
            KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG  +     + +  
Sbjct: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 891

Query: 761 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 819
            T+P R + +    + + VF++L  E W   +++ M  +      + ++ +M  GN V+ 
Sbjct: 892 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVL 949

Query: 820 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE 851
           NL +A+L+  F ++   N +  +ED  ++N++
Sbjct: 950 NLFLALLLSSFSSD---NLTAIEEDPDANNLQ 978



 Score =  132 bits (333), Expect = 3e-30
 Identities = 107/391 (27%), Positives = 182/391 (46%), Gaps = 66/391 (16%)

Query: 35  PPGL-EEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNP 79
           PPG+  EPL+  DP+                    A  A + L   +  R   IK++ + 
Sbjct: 67  PPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHS 126

Query: 80  WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGI 139
            F  + M  IL NC+ + M  P        D  K ++     I+ F   E ++K++A G 
Sbjct: 127 LFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEYTFTGIYTF---ESLVKILARGF 176

Query: 140 -FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRIL 198
             G+  +L D WN LDF +++   +   ++L N+  SA+RT RVLR LK I+ +P ++ +
Sbjct: 177 CVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNV--SALRTFRVLRALKTISVIPGLKTI 234

Query: 199 VNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF---LEENFTIQGDVALPP 255
           V  L+ ++  L +V++L  F   +F +IG+QL+ G L+++CF   LE N T++   ++  
Sbjct: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLE---SIMN 291

Query: 256 YYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGL 315
             + EED    F       + ++              C  S D              SG 
Sbjct: 292 TLESEEDFRKYFYYLEGSKDALL--------------CGFSTD--------------SGQ 323

Query: 316 CVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF 375
           C      Y   + G  NP  G  +FD   +A++ +F+++T + W  +    + A      
Sbjct: 324 CPEG---YTCVKIG-RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM 379

Query: 376 IYFILLIIVGSFFMINLCLVVIATQFSETKQ 406
           I+F+++I +GSF++INL L V+A  + E  Q
Sbjct: 380 IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410



 Score =  126 bits (317), Expect = 2e-28
 Identities = 111/413 (26%), Positives = 186/413 (45%), Gaps = 102/413 (24%)

Query: 40   EPLDGADPHVPHPDLAPIAFFCLRQTTSP---------RNWCIKMVCNPWFECVSMLVIL 90
            EP++  +P     D     F C +              R  C K+V + WFE   +L+IL
Sbjct: 1133 EPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMIL 1192

Query: 91   LNCVTLGMYQPCDDMDCLSDRCKILQV---FDDFIFIF-FAMEMVLKMVALGIFGKKCYL 146
            L+   L         D   +R K +++   + D IF + F +EM+LK +A   +G K Y 
Sbjct: 1193 LSSGALAFE------DIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA---YGYKTYF 1243

Query: 147  GDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVPSMRILVNLL 202
             + W  LDF IV   +  +V  +L   ++  + ++RT+R LRPL+A++R   MR++VN L
Sbjct: 1244 TNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1303

Query: 203  LDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEED 262
            +  +P + NVLL+C   + IF I+GV L+AG                      +Y+    
Sbjct: 1304 IGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------------------KFYE---- 1338

Query: 263  DEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRY 322
                  C  + D       ++P      R  C +  +V       Q++    L VN++  
Sbjct: 1339 ------CINTTDGSRFPASQVP-----NRSECFALMNV------SQNVRWKNLKVNFDNV 1381

Query: 323  YNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSF 372
                                +GY  + + QV T +GW  IMY  +D+          +S 
Sbjct: 1382 -------------------GLGY--LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSL 1420

Query: 373  YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            Y +IYF++ II GSFF +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1421 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1473



 Score =  114 bits (284), Expect = 1e-24
 Identities = 87/364 (23%), Positives = 159/364 (43%), Gaps = 73/364 (20%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ SP +  R +   I+ H LF  +++  I  NCI + +  P     + E        
Sbjct: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE-------- 156

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G   GE  +LR  WN LD  ++  + +   V+L         
Sbjct: 157  YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--------- 207

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 208  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267

Query: 1294 KGK--------------------------------FYHCLG----------VDTRNITNR 1311
             G                                 FY+  G           D+      
Sbjct: 268  MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327

Query: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371
              C+       +   +FD    A ++LF L ++D W N+           QQ +      
Sbjct: 328  YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLY----------QQTLRAAGKT 377

Query: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE---EKRLRRLEKKRRK 1428
             +++F+  + + SF+++N+ + VV   + +  Q    EEA+++E   ++ L RL+K++ +
Sbjct: 378  YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQEE 436

Query: 1429 AQRL 1432
            A+ +
Sbjct: 437  AEAI 440



 Score =  107 bits (266), Expect = 2e-22
 Identities = 82/309 (26%), Positives = 147/309 (47%), Gaps = 34/309 (11%)

Query: 1406 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1465
            +E EE+R++      R   K       PY+  +   +  I+ +    ++D+ IT  I LN
Sbjct: 690  EELEESRQKCPPWWYRFAHKFLIWNCSPYWIKF---KKCIYFIVMDPFVDLAITICIVLN 746

Query: 1466 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1525
             + M++EH+      +  L   N +FT +F  E VLKL+A     +F+  WN  D  IV 
Sbjct: 747  TLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 806

Query: 1526 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1585
            LS++ + L ++E           + ++R  R+ RV KL K    +  L+  +  ++  +G
Sbjct: 807  LSLVELFLADVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 856

Query: 1586 NLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVST 1641
            NL L+  ++ FI+A +G++LFGK     VC   + C     H    +F  +FL +F+V  
Sbjct: 857  NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLC 914

Query: 1642 GDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1699
            G+ W     +T+ DC     +  CL        + ++  ++    V++N+ +A+L+    
Sbjct: 915  GE-W----IETMWDCMEVAGQAMCL--------IVYMMVMVIGNLVVLNLFLALLLSSFS 961

Query: 1700 DSNKEAQED 1708
              N  A E+
Sbjct: 962  SDNLTAIEE 970



 Score =  106 bits (265), Expect = 2e-22
 Identities = 89/357 (24%), Positives = 163/357 (45%), Gaps = 57/357 (15%)

Query: 534  STDSGQEGSG---SGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAV--WLC- 587
            S+DS  E S    + SS+      D       E+  +  +  +E E    DG V  + C 
Sbjct: 1096 SSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCC 1155

Query: 588  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637
                    G +W   R     IV+  +F   I++ IL+++ ++  E  + E+ + +  IL
Sbjct: 1156 QVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIIL 1215

Query: 638  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV----GQAD-GGL 692
            E  + +FT +F LEM+LK  A+G   Y  N +   D +IV +S+  +V    G +D G +
Sbjct: 1216 EYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPI 1275

Query: 693  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 1276 KSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1335

Query: 753  FSLRTDTGD-------TVPDRK-------------------NFDSLLWAIVTVFQILTQE 786
            F    +T D        VP+R                    NFD++    +++ Q+ T +
Sbjct: 1336 FYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFK 1395

Query: 787  DWNVVLYNGMAST----------SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 833
             W +++Y  + S           S +  +YFV  + FG++   NL + ++++ F  +
Sbjct: 1396 GWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452



 Score =  102 bits (254), Expect = 4e-21
 Identities = 73/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+ +     ++ ++ FD  ++  I LN +T+ +E+       TE ++    N +F  +
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWI--NVVFIIL 1546

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1547 FTGECVLKLISLRHY-----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA----- 1656

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
                       + D        ++  +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1657 --------YVKKED-------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P   H          NP + + YF+S+++I    V+NM++ V++ENF
Sbjct: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 78/287 (27%), Positives = 131/287 (45%), Gaps = 41/287 (14%)

Query: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
            +V ++ F+  IM+ I +N V+M +E   Q + +T +L   NVVF  +F  E +LKL +  
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559

Query: 661  LFDYLRNPYNIFDSIIVIISIWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 709
             + Y    +NIFD ++VIIS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615

Query: 710  MPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNF 769
               +R  L  LM ++  +    +LL L +FI++I GM  F           D + D  NF
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEDGINDMFNF 1670

Query: 770  DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFV 808
            ++   +++ +FQI T   W+ +L   + S  P                         YFV
Sbjct: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730

Query: 809  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 855
            + +     V+ N+ +A+++E F    + +     ED      E ++K
Sbjct: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 72/298 (24%), Positives = 133/298 (44%), Gaps = 40/298 (13%)

Query: 1104 PDWCEVREDWSVYLFSPE-NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEA 1161
            P W      + ++  SP   +F+     I+     D  +   I LN + +A+E  P  E 
Sbjct: 701  PWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEE 760

Query: 1162 GSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIV 1221
                   L + N +FT IF  EM LK++++  Y     Y +  WN+ D  +V +S++++ 
Sbjct: 761  FKN---VLAIGNLVFTGIFAAEMVLKLIAMDPY----EYFQVGWNIFDSLIVTLSLVELF 813

Query: 1222 VSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAF 1281
              LA   G      L VLR  R LR  ++    P L ++++ + +S+  +GN+ L+    
Sbjct: 814  --LADVEG------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII 865

Query: 1282 FIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVL 1341
              IF ++G+QLF   +  C+           DC     RW  H  +F      L+   VL
Sbjct: 866  VFIFAVVGMQLFGKSYKECV------CKINDDCTLP--RW--HMNDF--FHSFLIVFRVL 913

Query: 1342 ASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
              +  W+  M++ ++                L+ ++  ++I +  VLN+F+ +++ +F
Sbjct: 914  CGE--WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 66/293 (22%), Positives = 134/293 (45%), Gaps = 70/293 (23%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           F+  IM  IL N + M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 128 FSMLIMCTILTNCIFMTMNN---PPDWTKNVEY---TFTGIYTFESLVKILARGFCVGEF 181

Query: 663 DYLRNPYNIFDSIIVIIS-IWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D ++++ + + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 182 TFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 239

Query: 722 KTMDNVATFCMLLMLFIFIFSILGM----------------------------------- 746
           +++  ++   +L +  + +F+++G+                                   
Sbjct: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDF 299

Query: 747 -----HIFGCKFSL----RTDTGDTV-----------PDR--KNFDSLLWAIVTVFQILT 784
                ++ G K +L     TD+G              PD    +FD+  WA + +F+++T
Sbjct: 300 RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMT 359

Query: 785 QEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 837
           Q+ W  +    + +      ++FV ++  G++ L NL++A++   ++ +  AN
Sbjct: 360 QDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 50/185 (27%), Positives = 95/185 (51%), Gaps = 17/185 (9%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVLK 133
           +V +P+ +    + I+LN + + M     +   +++  K +    + +F   FA EMVLK
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAM-----EHHPMTEEFKNVLAIGNLVFTGIFAAEMVLK 783

Query: 134 MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSL-DLQNINLSAIRTVRVLRPLKAINRV 192
           ++A+  +    Y    WN  D  IV   +VE  L D++   LS +R+ R+LR  K     
Sbjct: 784 LIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEG--LSVLRSFRLLRVFKLAKSW 838

Query: 193 PSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVA 252
           P++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  
Sbjct: 839 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDCT 893

Query: 253 LPPYY 257
           LP ++
Sbjct: 894 LPRWH 898



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 73/338 (21%), Positives = 134/338 (39%), Gaps = 95/338 (28%)

Query: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1501
            ++L+HS+        F   I+C  +        N P       K   Y FT ++  E+++
Sbjct: 121  KILVHSL--------FSMLIMCTILTNCIFMTMNNPPDWT---KNVEYTFTGIYTFESLV 169

Query: 1502 KLVAFGLR----RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1557
            K++A G       F +D WN LD  +++ +     L E        +N   +  +R  R+
Sbjct: 170  KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218

Query: 1558 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLL--FMLLFFIYAALGV------------ 1603
             R LK + +  G++ ++  ++Q++ ++ ++ +L  F L  F    L +            
Sbjct: 219  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278

Query: 1604 ------------------ELFGK-----------LVCN---DENPC-EGMS--------- 1621
                              E F K           L+C    D   C EG +         
Sbjct: 279  SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338

Query: 1622 -RHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1680
              + +F+ F  AFL LF++ T D W  + + TLR           +      ++FV  + 
Sbjct: 339  YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLR-----------AAGKTYMIFFVVVIF 387

Query: 1681 TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE 1718
               F LIN+++AV+    ++ N+   E+A+   ELE +
Sbjct: 388  LGSFYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 15/165 (9%)

Query: 75   MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
            +V N  F+   M++I LN VT+ + +            ++L   +    I F  E VLK+
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT----EVLYWINVVFIILFTGECVLKL 1555

Query: 135  VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLK 187
            ++L    +  Y    WN  DF +V+  +V   L        +       IR  R+ R L+
Sbjct: 1556 ISL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611

Query: 188  AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
             +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656



 Score = 33.9 bits (76), Expect = 1.8
 Identities = 15/59 (25%), Positives = 39/59 (66%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A      I +++++++G+  ++NL L ++ + FS
Sbjct: 904 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 961



 Score = 31.6 bits (70), Expect = 8.9
 Identities = 18/85 (21%), Positives = 35/85 (41%), Gaps = 21/85 (24%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA---------------------HSFYNFIY 377
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      Y
Sbjct: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728

Query: 378  FILLIIVGSFFMINLCLVVIATQFS 402
            F+  II+    ++N+ + VI   FS
Sbjct: 1729 FVSYIIISFLVVVNMYIAVILENFS 1753


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score =  338 bits (866), Expect = 4e-92
 Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370

Query: 1303 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353
                 D   + N S+C A        RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430

Query: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413
             +D+  V+ QP    N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490

Query: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550

Query: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531
            E  +Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609

Query: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667

Query: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722

Query: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             L     DC  D+    SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782

Query: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725
             +E+ E  +E D E+  E+     P
Sbjct: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807



 Score =  143 bits (360), Expect = 2e-33
 Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)

Query: 584  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 738  IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797

Query: 644  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857

Query: 704  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 756
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG       CK S  
Sbjct: 858  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915

Query: 757  TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 815
                D    R +      + + VF++L  E W   +++ M        L  F+ +M  GN
Sbjct: 916  ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971

Query: 816  YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861
             V+ NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 972  LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015



 Score =  129 bits (323), Expect = 4e-29
 Identities = 109/392 (27%), Positives = 181/392 (46%), Gaps = 42/392 (10%)

Query: 58  AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
           A + L      R   IK++ +  F  + M  IL NCV + M  P        D  K ++ 
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160

Query: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
               I+ F   E ++K++A G   +   +L D WN LDF ++    V   ++L N+  SA
Sbjct: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNV--SA 215

Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
           +RT RVLR LK I+ +P ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275

Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
           N+C           +  PP     E +   F  +    NG      +        E    
Sbjct: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322

Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
           K   Y F  G+ D    G   +  +     +C     NP+ G  +FD   +A++ +F+++
Sbjct: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381

Query: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
           T + W  +    + A      I+F+L+I +GSF++INL L V+A  +          +E 
Sbjct: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441

Query: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
           K+ E + MLEQ   +Q    ++  A+ AE  D
Sbjct: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473



 Score =  112 bits (280), Expect = 4e-24
 Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)

Query: 1419 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1467
            +  LE+ R+K     Y +A  C            + L++ +    ++D+ IT  I LN +
Sbjct: 715  MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774

Query: 1468 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1527
             M++EHY       + L   N +FT +F  E  LK++A     +F++ WN  D  IV LS
Sbjct: 775  FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834

Query: 1528 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1587
            +M + L  +E           + ++R  R+ RV KL K    +  L+  +  ++  +GNL
Sbjct: 835  LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884

Query: 1588 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
             L+  ++ FI+A +G++LFGK     VC   N CE    H    +F  +FL +F+V  G+
Sbjct: 885  TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942

Query: 1644 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             W     +T+ DC     +  CL+         F+  ++    V++N+ +A+L+      
Sbjct: 943  -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989

Query: 1702 NKEAQED 1708
            N  A +D
Sbjct: 990  NLAATDD 996



 Score =  102 bits (255), Expect = 3e-21
 Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+F+ +    +  ++FD  ++  I LN +T+ +E        T  ++    N +F  +
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
             +G+D                     +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P  +H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1178
            P  + + L   ++     D  +   I LN + +A+E  P  E  S+    L+V N +FT 
Sbjct: 744  PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800

Query: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238
            IF  EM LK++++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L V
Sbjct: 801  IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848

Query: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
            LR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   + 
Sbjct: 849  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908

Query: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358
             C+      I+N  DC     RW  H    D     L+   VL  +  W+  M++ ++  
Sbjct: 909  ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954

Query: 1359 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
                          L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 955  G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)

Query: 534  STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 587
            S++S  E S    +A    E       +  +G   E+  EE  E +A   +  V  + C 
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182

Query: 588  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637
                    G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242

Query: 638  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 692
            E  + VFT +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302

Query: 693  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362

Query: 753  F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 786
            F   +   TG+                            + NFD++    +++ Q+ T +
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422

Query: 787  DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 836
             W  ++Y  + S +           +  LYFV  + FG++   NL + ++++ F  +   
Sbjct: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479

Query: 837  NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
             + +  +D   +  EE  K    +   G  K   PIP   N
Sbjct: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 85/371 (22%), Positives = 157/371 (42%), Gaps = 71/371 (19%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ +P N  R L   I+ H LF+ +++  I  NC+ + +  P     + E        
Sbjct: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V+L         
Sbjct: 160  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNL--------- 210

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 211  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270

Query: 1294 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1342
             G   + CL     N            N  D     +      +N+D   +     + L 
Sbjct: 271  MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330

Query: 1343 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1375
             +                +G++        N  Y   D  +   +    +   + W  LY
Sbjct: 331  GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390

Query: 1376 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1419
                        I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++ L
Sbjct: 391  QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450

Query: 1420 RRLEKKRRKAQ 1430
             +L+K++ +AQ
Sbjct: 451  EQLKKQQEEAQ 461



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 30   SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
            S   S   +  P +G  P V P   L P A F   C+R+                 + R 
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199

Query: 71   WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
             C K+V + WFE   + +ILL+   L       +        K +  + D +F + F +E
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256

Query: 130  MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
            M+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++RT+R LRP
Sbjct: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313

Query: 186  LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            L+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)

Query: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
            V  + F+  IM+ I +N V+M +E  +Q +E+TNIL   N+VF  +F  E +LKL +   
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587

Query: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646

Query: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701

Query: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761

Query: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 859
                V+ N+ +A+++E F    + +     ED               ++   EF KL + 
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821

Query: 860  LDSSGDPKLCPIP 872
             D+   P L   P
Sbjct: 1822 ADALDPPLLIAKP 1834



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           FN  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184

Query: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVNL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 722 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
           +++  ++   +L +  + +F+++G+ +F    +LR       PD  +F+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
           +V +P+ +    + I+LN + + M    +          +L V +      F  EM LK+
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810

Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
           +A+  +    Y  + WN  D FIV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920

Query: 254 PPYY 257
           P ++
Sbjct: 921 PRWH 924



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN VT  M    DD     +   IL   +    + F  E VLK+++L  +
Sbjct: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
                Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644

Query: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)

Query: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 364  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412

Query: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1739
             F LIN+++AV+    ++ N+   E+AE  +AE +  LE         +    +  A  R
Sbjct: 413  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472

Query: 1740 GPGGAGGGG 1748
               GAGG G
Sbjct: 473  DFSGAGGIG 481



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425

Query: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458



 Score = 33.1 bits (74), Expect = 3.1
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score =  338 bits (866), Expect = 4e-92
 Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370

Query: 1303 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353
                 D   + N S+C A        RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430

Query: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413
             +D+  V+ QP    N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490

Query: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550

Query: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531
            E  +Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609

Query: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667

Query: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722

Query: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             L     DC  D+    SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782

Query: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725
             +E+ E  +E D E+  E+     P
Sbjct: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807



 Score =  143 bits (360), Expect = 2e-33
 Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)

Query: 584  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 738  IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797

Query: 644  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857

Query: 704  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 756
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG       CK S  
Sbjct: 858  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915

Query: 757  TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 815
                D    R +      + + VF++L  E W   +++ M        L  F+ +M  GN
Sbjct: 916  ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971

Query: 816  YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861
             V+ NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 972  LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015



 Score =  130 bits (328), Expect = 1e-29
 Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)

Query: 58  AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
           A + L      R   IK++ +  F  + M  IL NCV + M  P        D  K ++ 
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160

Query: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
               I+ F   E ++K++A G   +   +L D WN LDF ++    V   +DL N+  SA
Sbjct: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215

Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
           +RT RVLR LK I+ +P ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275

Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
           N+C           +  PP     E +   F  +    NG      +        E    
Sbjct: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322

Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
           K   Y F  G+ D    G   +  +     +C     NP+ G  +FD   +A++ +F+++
Sbjct: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381

Query: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
           T + W  +    + A      I+F+L+I +GSF++INL L V+A  +          +E 
Sbjct: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441

Query: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
           K+ E + MLEQ   +Q    ++  A+ AE  D
Sbjct: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473



 Score =  112 bits (280), Expect = 4e-24
 Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)

Query: 1419 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1467
            +  LE+ R+K     Y +A  C            + L++ +    ++D+ IT  I LN +
Sbjct: 715  MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774

Query: 1468 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1527
             M++EHY       + L   N +FT +F  E  LK++A     +F++ WN  D  IV LS
Sbjct: 775  FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834

Query: 1528 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1587
            +M + L  +E           + ++R  R+ RV KL K    +  L+  +  ++  +GNL
Sbjct: 835  LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884

Query: 1588 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
             L+  ++ FI+A +G++LFGK     VC   N CE    H    +F  +FL +F+V  G+
Sbjct: 885  TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942

Query: 1644 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             W     +T+ DC     +  CL+         F+  ++    V++N+ +A+L+      
Sbjct: 943  -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989

Query: 1702 NKEAQED 1708
            N  A +D
Sbjct: 990  NLAATDD 996



 Score =  102 bits (255), Expect = 3e-21
 Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+F+ +    +  ++FD  ++  I LN +T+ +E        T  ++    N +F  +
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
             +G+D                     +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P  +H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1178
            P  + + L   ++     D  +   I LN + +A+E  P  E  S+    L+V N +FT 
Sbjct: 744  PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800

Query: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238
            IF  EM LK++++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L V
Sbjct: 801  IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848

Query: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
            LR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   + 
Sbjct: 849  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908

Query: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358
             C+      I+N  DC     RW  H    D     L+   VL  +  W+  M++ ++  
Sbjct: 909  ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954

Query: 1359 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
                          L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 955  G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)

Query: 534  STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 587
            S++S  E S    +A    E       +  +G   E+  EE  E +A   +  V  + C 
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182

Query: 588  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637
                    G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242

Query: 638  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 692
            E  + VFT +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302

Query: 693  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362

Query: 753  F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 786
            F   +   TG+                            + NFD++    +++ Q+ T +
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422

Query: 787  DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 836
             W  ++Y  + S +           +  LYFV  + FG++   NL + ++++ F  +   
Sbjct: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479

Query: 837  NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
             + +  +D   +  EE  K    +   G  K   PIP   N
Sbjct: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ +P N  R L   I+ H LF+ +++  I  NC+ + +  P     + E        
Sbjct: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V L         
Sbjct: 160  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 211  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270

Query: 1294 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1342
             G   + CL     N            N  D     +      +N+D   +     + L 
Sbjct: 271  MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330

Query: 1343 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1375
             +                +G++        N  Y   D  +   +    +   + W  LY
Sbjct: 331  GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390

Query: 1376 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1419
                        I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++ L
Sbjct: 391  QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450

Query: 1420 RRLEKKRRKAQ 1430
             +L+K++ +AQ
Sbjct: 451  EQLKKQQEEAQ 461



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 30   SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
            S   S   +  P +G  P V P   L P A F   C+R+                 + R 
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199

Query: 71   WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
             C K+V + WFE   + +ILL+   L       +        K +  + D +F + F +E
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256

Query: 130  MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
            M+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++RT+R LRP
Sbjct: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313

Query: 186  LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            L+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)

Query: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
            V  + F+  IM+ I +N V+M +E  +Q +E+TNIL   N+VF  +F  E +LKL +   
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587

Query: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646

Query: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701

Query: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761

Query: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 859
                V+ N+ +A+++E F    + +     ED               ++   EF KL + 
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821

Query: 860  LDSSGDPKLCPIP 872
             D+   P L   P
Sbjct: 1822 ADALDPPLLIAKP 1834



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           FN  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184

Query: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 722 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
           +++  ++   +L +  + +F+++G+ +F    +LR       PD  +F+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
           +V +P+ +    + I+LN + + M    +          +L V +      F  EM LK+
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810

Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
           +A+  +    Y  + WN  D FIV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920

Query: 254 PPYY 257
           P ++
Sbjct: 921 PRWH 924



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN VT  M    DD     +   IL   +    + F  E VLK+++L  +
Sbjct: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
                Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644

Query: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)

Query: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 364  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412

Query: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1739
             F LIN+++AV+    ++ N+   E+AE  +AE +  LE         +    +  A  R
Sbjct: 413  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472

Query: 1740 GPGGAGGGG 1748
               GAGG G
Sbjct: 473  DFSGAGGIG 481



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425

Query: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458



 Score = 33.1 bits (74), Expect = 3.1
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score =  338 bits (866), Expect = 4e-92
 Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)

Query: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257

Query: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310

Query: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370

Query: 1303 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353
                 D   + N S+C A        RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430

Query: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413
             +D+  V+ QP    N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490

Query: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550

Query: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531
            E  +Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609

Query: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667

Query: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722

Query: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             L     DC  D+    SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782

Query: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725
             +E+ E  +E D E+  E+     P
Sbjct: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807



 Score =  143 bits (360), Expect = 2e-33
 Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)

Query: 584  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 738  IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797

Query: 644  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857

Query: 704  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 756
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG       CK S  
Sbjct: 858  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915

Query: 757  TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 815
                D    R +      + + VF++L  E W   +++ M        L  F+ +M  GN
Sbjct: 916  ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971

Query: 816  YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861
             V+ NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 972  LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015



 Score =  130 bits (328), Expect = 1e-29
 Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)

Query: 58  AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
           A + L      R   IK++ +  F  + M  IL NCV + M  P        D  K ++ 
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160

Query: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
               I+ F   E ++K++A G   +   +L D WN LDF ++    V   +DL N+  SA
Sbjct: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215

Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
           +RT RVLR LK I+ +P ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275

Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
           N+C           +  PP     E +   F  +    NG      +        E    
Sbjct: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322

Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
           K   Y F  G+ D    G   +  +     +C     NP+ G  +FD   +A++ +F+++
Sbjct: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381

Query: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
           T + W  +    + A      I+F+L+I +GSF++INL L V+A  +          +E 
Sbjct: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441

Query: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
           K+ E + MLEQ   +Q    ++  A+ AE  D
Sbjct: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473



 Score =  112 bits (280), Expect = 4e-24
 Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)

Query: 1419 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1467
            +  LE+ R+K     Y +A  C            + L++ +    ++D+ IT  I LN +
Sbjct: 715  MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774

Query: 1468 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1527
             M++EHY       + L   N +FT +F  E  LK++A     +F++ WN  D  IV LS
Sbjct: 775  FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834

Query: 1528 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1587
            +M + L  +E           + ++R  R+ RV KL K    +  L+  +  ++  +GNL
Sbjct: 835  LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884

Query: 1588 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643
             L+  ++ FI+A +G++LFGK     VC   N CE    H    +F  +FL +F+V  G+
Sbjct: 885  TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942

Query: 1644 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701
             W     +T+ DC     +  CL+         F+  ++    V++N+ +A+L+      
Sbjct: 943  -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989

Query: 1702 NKEAQED 1708
            N  A +D
Sbjct: 990  NLAATDD 996



 Score =  102 bits (255), Expect = 3e-21
 Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179
            P N+F+ +    +  ++FD  ++  I LN +T+ +E        T  ++    N +F  +
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573

Query: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628

Query: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687

Query: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359
             +G+D                     +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728

Query: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399
             D  P  +H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)

Query: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1178
            P  + + L   ++     D  +   I LN + +A+E  P  E  S+    L+V N +FT 
Sbjct: 744  PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800

Query: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238
            IF  EM LK++++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L V
Sbjct: 801  IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848

Query: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298
            LR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   + 
Sbjct: 849  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908

Query: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358
             C+      I+N  DC     RW  H    D     L+   VL  +  W+  M++ ++  
Sbjct: 909  ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954

Query: 1359 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399
                          L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 955  G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)

Query: 534  STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 587
            S++S  E S    +A    E       +  +G   E+  EE  E +A   +  V  + C 
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182

Query: 588  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637
                    G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242

Query: 638  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 692
            E  + VFT +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302

Query: 693  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362

Query: 753  F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 786
            F   +   TG+                            + NFD++    +++ Q+ T +
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422

Query: 787  DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 836
             W  ++Y  + S +           +  LYFV  + FG++   NL + ++++ F  +   
Sbjct: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479

Query: 837  NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876
             + +  +D   +  EE  K    +   G  K   PIP   N
Sbjct: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)

Query: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173
            ++Y+ +P N  R L   I+ H LF+ +++  I  NC+ + +  P     + E        
Sbjct: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159

Query: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V L         
Sbjct: 160  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210

Query: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 211  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270

Query: 1294 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1342
             G   + CL     N            N  D     +      +N+D   +     + L 
Sbjct: 271  MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330

Query: 1343 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1375
             +                +G++        N  Y   D  +   +    +   + W  LY
Sbjct: 331  GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390

Query: 1376 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1419
                        I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++ L
Sbjct: 391  QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450

Query: 1420 RRLEKKRRKAQ 1430
             +L+K++ +AQ
Sbjct: 451  EQLKKQQEEAQ 461



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 30   SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
            S   S   +  P +G  P V P   L P A F   C+R+                 + R 
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199

Query: 71   WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
             C K+V + WFE   + +ILL+   L       +        K +  + D +F + F +E
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256

Query: 130  MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
            M+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++RT+R LRP
Sbjct: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313

Query: 186  LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
            L+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)

Query: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661
            V  + F+  IM+ I +N V+M +E  +Q +E+TNIL   N+VF  +F  E +LKL +   
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587

Query: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646

Query: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701

Query: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761

Query: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 859
                V+ N+ +A+++E F    + +     ED               ++   EF KL + 
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821

Query: 860  LDSSGDPKLCPIP 872
             D+   P L   P
Sbjct: 1822 ADALDPPLLIAKP 1834



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)

Query: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662
           FN  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184

Query: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242

Query: 722 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770
           +++  ++   +L +  + +F+++G+ +F    +LR       PD  +F+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462

Query: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
           +V +P+ +    + I+LN + + M    +          +L V +      F  EM LK+
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810

Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
           +A+  +    Y  + WN  D FIV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865

Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920

Query: 254 PPYY 257
           P ++
Sbjct: 921 PRWH 924



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
            F+   M++I LN VT  M    DD     +   IL   +    + F  E VLK+++L  +
Sbjct: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588

Query: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
                Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644

Query: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)

Query: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 364  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412

Query: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1739
             F LIN+++AV+    ++ N+   E+AE  +AE +  LE         +    +  A  R
Sbjct: 413  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472

Query: 1740 GPGGAGGGG 1748
               GAGG G
Sbjct: 473  DFSGAGGIG 481



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425

Query: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458



 Score = 33.1 bits (74), Expect = 3.1
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987


>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 20 [Homo sapiens]
          Length = 2127

 Score =  337 bits (864), Expect = 8e-92
 Identities = 205/647 (31%), Positives = 357/647 (55%), Gaps = 52/647 (8%)

Query: 1082 EDEEEIDYTLCFRVRKMIDVY-KPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV 1140
            EDEEE +  +  R R + +++ K     + E  + ++FS  NRFR+ C  I+   +F  +
Sbjct: 846  EDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNL 905

Query: 1141 VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY 1200
            +L FI L+ I++A E P ++  S     L  ++Y+FT+IF  E+ LK+ + G +  + ++
Sbjct: 906  ILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964

Query: 1201 LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1260
             R+ +N+LD  +V VS+I   +  ++      + V+++LR+LR LRPLR I+RA GLK V
Sbjct: 965  CRNYFNILDLLVVSVSLISFGIQSSA------INVVKILRVLRVLRPLRAINRAKGLKHV 1018

Query: 1261 VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANY- 1319
            V+ +  +++ IGNIV++      +F  +GVQLFKGK Y C      +    ++C   NY 
Sbjct: 1019 VQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC---SDSSKQTEAEC-KGNYI 1074

Query: 1320 ---------------RWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQP 1364
                            W + K++FDN+  A+M+LF +++ +GW  ++Y  +D+   D+ P
Sbjct: 1075 TYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1134

Query: 1365 VTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE-EKRLRRLE 1423
            + N+   + ++FI +++I++FF++N+FVG V+  F    Q Q  +E +  E +K  R+  
Sbjct: 1135 IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QEQGEQEYKNCELDKNQRQCV 1190

Query: 1424 KKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETA 1483
            +   KA+ L  Y      +  +  +  S Y +  +  +I LN + ++++HY Q    + A
Sbjct: 1191 EYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIA 1250

Query: 1484 LKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALP 1543
            +   N +FT +F +E +LKL+AF  + +F D WN  D  IV+ S++ I +   E+N A  
Sbjct: 1251 MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEE 1308

Query: 1544 INPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGV 1603
             +   I   R+ R+ R++KLL    G+R LL T +++   +  + LL ++LFFIYA +G+
Sbjct: 1309 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1368

Query: 1604 ELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM-----------KDT 1652
            ++FGK+  ND      ++R+  F+ F  A L LF+ +TG+ W  IM           +  
Sbjct: 1369 QVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1425

Query: 1653 LRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1699
              + T  E  C SS    +  YF+SF +   F++IN+ VAV+M + D
Sbjct: 1426 PSNSTEGETPCGSSF---AVFYFISFYMLCAFLIINLFVAVIMDNFD 1469



 Score =  172 bits (437), Expect = 2e-42
 Identities = 124/404 (30%), Positives = 194/404 (48%), Gaps = 83/404 (20%)

Query: 56  PIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKIL 115
           P A  CL      R  CI +V    FE + +L I  NCV L +Y P  + D  +    + 
Sbjct: 101 PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE 160

Query: 116 QVFDDFIF-IFFAMEMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-- 171
           +V  +++F I F +E  LK++A G+ F    YL + WN LDF IV+ G+    L+     
Sbjct: 161 RV--EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA 218

Query: 172 ------------INLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFV 219
                        ++ A+R  RVLRPL+ ++ VPS+++++N ++  +  L ++ LL  FV
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278

Query: 220 FFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMG 279
             I+ IIG++L+ G +   C+ +E      DV       P EDD  P  C+L        
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGI---ADV-------PAEDDPSP--CAL-------- 318

Query: 280 CHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN 339
                                 + G GRQ  N +           VC+ G   P  G  N
Sbjct: 319 ----------------------ETGHGRQCQNGT-----------VCKPGWDGPKHGITN 345

Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           FDN  +A + +FQ IT+EGW +++Y+V DA    + +IYF+ LII+GSFF++NL L V++
Sbjct: 346 FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLS 405

Query: 399 TQFSETKQ-----------REHRLMLEQRQRYLSSSTVASYAEP 431
            +FS+ ++           RE + + E  + YL   T A   +P
Sbjct: 406 GEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 449



 Score =  160 bits (405), Expect = 1e-38
 Identities = 110/358 (30%), Positives = 178/358 (49%), Gaps = 44/358 (12%)

Query: 525 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAV 584
           D  +P  +    S  E   + + AGG+ E +  GAR +   + S+  +            
Sbjct: 457 DEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSR------------ 504

Query: 585 WLCGDVWRE----TRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEIC 640
                 WR      R K R  V S  F   ++  + +NT+++  EH+ QP  LT + +  
Sbjct: 505 -----YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559

Query: 641 NVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG-----QADGGLSVL 695
           N    ++F  EM+LK+ + GL  Y  + +N FD  +V   I E +       +  G+SVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619

Query: 696 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL 755
           R  RLLR+ K+ R+  +L   +  L+ ++ ++A+  +LL LFI IFS+LGM +FG KF+ 
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679

Query: 756 RTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNG-MASTSP-----WASLYFVA 809
                +    R  FD+   +++TVFQILT EDWN V+Y+G MA   P        +YF+ 
Sbjct: 680 ----DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFII 735

Query: 810 LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK 867
           L   GNY+L N+ +AI V+        N + ++   S+   EE +K ++ L  +  P+
Sbjct: 736 LFICGNYILLNVFLAIAVD--------NLADAESLTSAQKEEEEEKERKKLARTASPE 785



 Score =  154 bits (388), Expect = 1e-36
 Identities = 110/348 (31%), Positives = 176/348 (50%), Gaps = 53/348 (15%)

Query: 1121 ENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN-----YI 1175
            +N  R  C +I+  K F+ ++L  IF NC+ +A+  P  E  S      T SN     Y+
Sbjct: 110  KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA----TNSNLERVEYL 165

Query: 1176 FTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLAS-AGGAKILG 1234
            F  IF  E  LKV++ GL F   AYLR+ WN+LD  +V V +   ++  A+ A GA  LG
Sbjct: 166  FLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALG 225

Query: 1235 V------LRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGIL 1288
                   ++ LR  R LRPLR++S  P L++V+ ++I ++ P+ +I L+     II+ I+
Sbjct: 226  GKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAII 285

Query: 1289 GVQLFKGKF----YHCLGVDT-----------------RNITNRSDCMAANYRWVHHKYN 1327
            G++LF GK     Y+  G+                   R   N + C        H   N
Sbjct: 286  GLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITN 345

Query: 1328 FDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV 1387
            FDN   A++++F   + +GW +++Y   DAV  D         W  +YF++ ++I SFFV
Sbjct: 346  FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFV 396

Query: 1388 LNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYY 1435
            LN+ +GV+   F K     E E+A+ R +   ++L +K++  + L  Y
Sbjct: 397  LNLVLGVLSGEFSK-----EREKAKARGD--FQKLREKQQLEEDLKGY 437



 Score =  122 bits (307), Expect = 3e-27
 Identities = 73/259 (28%), Positives = 138/259 (53%), Gaps = 16/259 (6%)

Query: 1458 ITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWN 1517
            + F++ LN +T++ EHYNQP  L       N     +F  E +LK+ + GL+ +F   +N
Sbjct: 530  VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 1518 QLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1577
            + D  +V   ++   L E +I     ++P  I ++R +R+ R+ K+ +    +  L+ ++
Sbjct: 590  RFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644

Query: 1578 VQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLF 1637
            + ++  + +L LL  L   I++ LG++LFG     DE      +R +TF+NF  + LT+F
Sbjct: 645  LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM----QTRRSTFDNFPQSLLTVF 700

Query: 1638 QVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKH 1697
            Q+ TG++WN +M D +    +   S    L  +   YF+   +   ++L+NV +A+ + +
Sbjct: 701  QILTGEDWNSVMYDGI--MAYGGPSFPGMLVCI---YFIILFICGNYILLNVFLAIAVDN 755

Query: 1698 LDDSNK--EAQEDAEMDAE 1714
            L D+     AQ++ E + E
Sbjct: 756  LADAESLTSAQKEEEEEKE 774



 Score =  120 bits (300), Expect = 2e-26
 Identities = 94/316 (29%), Positives = 156/316 (49%), Gaps = 38/316 (12%)

Query: 1122 NRF-RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1180
            NRF R  C+  +   +F ++V+  +FLN +TIA E        TE      +N    A+F
Sbjct: 510  NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTE--VQDTANKALLALF 567

Query: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240
              EM LK+ SLGL    QAY  S +N  D F+V   I++ ++          + VLR +R
Sbjct: 568  TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVR 623

Query: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300
            LLR  +  R  +    L  +V +L++S++ I +++L+   F IIF +LG+QLF GKF + 
Sbjct: 624  LLRIFKITRYWN---SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679

Query: 1301 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1360
              + TR  T                  FDN  Q+L+++F + + + W ++MY+G+ A   
Sbjct: 680  DEMQTRRST------------------FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 721

Query: 1361 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCR-----QHQEAEEARRRE 1415
               P       + +YFI   +  ++ +LN+F+ + V+N          Q +E EE  R++
Sbjct: 722  PSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKK 777

Query: 1416 EKRLRRLEKKRRKAQR 1431
              R    EKK+   ++
Sbjct: 778  LARTASPEKKQELVEK 793



 Score =  107 bits (268), Expect = 1e-22
 Identities = 78/303 (25%), Positives = 150/303 (49%), Gaps = 41/303 (13%)

Query: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET-ALKYCNYMFTTVFVLEAV 1500
            RL  H +         I F I L+ ++++ E   Q TS     L   +Y+FT++F LE +
Sbjct: 890  RLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEII 949

Query: 1501 LKLVAFGL----RRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLR 1556
            LK+ A+G       F ++ +N LDL +V +S++   ++   IN        +++I+RVLR
Sbjct: 950  LKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN--------VVKILRVLR 1001

Query: 1557 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL-VCND- 1613
            + R L+ +  A G++ ++  V  A+  +GN+ ++  LL F++A +GV+LF GKL  C+D 
Sbjct: 1002 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 1614 ----ENPCEGM--------------------SRHATFENFGMAFLTLFQVSTGDNWNGIM 1649
                E  C+G                     +    F+N   A + LF VST + W  ++
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 1650 KDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDA 1709
              ++   T D+    +    +S ++F+ +++   F ++N+ V  ++    +  ++  ++ 
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEIS-IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC 1180

Query: 1710 EMD 1712
            E+D
Sbjct: 1181 ELD 1183



 Score =  107 bits (267), Expect = 1e-22
 Identities = 70/257 (27%), Positives = 131/257 (50%), Gaps = 30/257 (11%)

Query: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
            +V+S YF   + + IL+NT+ + ++H+ Q       + I N++FT +F +EMILKL AF 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 661  LFDYLRNPYNIFDSIIVIISIWEI----VGQADG----GLSVLRTFRLLRVLKLVRFMPA 712
               Y  + +N FD++IV+ SI +I    V  A+      ++  R FR++R++KL+     
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334

Query: 713  LRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSL 772
            +R  L   +K+   +    +L+++  FI++++GM +FG K +L   T   +    NF + 
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIALNDTT--EINRNNNFQTF 1391

Query: 773  LWAIVTVFQILTQEDWNVVLYNGMAST-------------------SPWASLYFVALMTF 813
              A++ +F+  T E W  ++   M                      S +A  YF++    
Sbjct: 1392 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1451

Query: 814  GNYVLFNLLVAILVEGF 830
              +++ NL VA++++ F
Sbjct: 1452 CAFLIINLFVAVIMDNF 1468



 Score =  105 bits (261), Expect = 6e-22
 Identities = 116/564 (20%), Positives = 225/564 (39%), Gaps = 110/564 (19%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF------IYFILLIIVGSFFMINLC 393
            FDN   + + +FQ++T E W  +MY  + A+   +F      IYFI+L I G++ ++N+ 
Sbjct: 689  FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748

Query: 394  LVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRA 453
            L +     ++ +        E+ ++      +A  A P    E +           ++ A
Sbjct: 749  LAIAVDNLADAESLTSAQKEEEEEK--ERKKLARTASPEKKQELV-----------EKPA 795

Query: 454  LGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLAS 513
            +G     +S+ + +  ++       P A +     L P  +  D +P+    P P T   
Sbjct: 796  VG-----ESKEEKIELKSITADGESPPATKINMDDLQPNENE-DKSPY----PNPETTGE 845

Query: 514  DPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 573
            +    P  +   G RP  L                                   SEL  +
Sbjct: 846  EDEEEP--EMPVGPRPRPL-----------------------------------SELHLK 868

Query: 574  EEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEEL 633
            E+     + + +         R +   IV+   F   I+  IL++++S+  E   Q    
Sbjct: 869  EKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSF 928

Query: 634  TN-ILEICNVVFTSMFALEMILKLAAFGLF----DYLRNPYNIFDSIIVIISI--WEIVG 686
             N IL   + VFTS+F LE+ILK+ A+G F     + RN +NI D ++V +S+  + I  
Sbjct: 929  RNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQS 988

Query: 687  QADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGM 746
             A   + +LR  R+LR L+ +     L+  +  +   +  +    ++  L  F+F+ +G+
Sbjct: 989  SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGV 1048

Query: 747  HIFGCKFSLRTDTGDTVP---------------------------DRKNFDSLLWAIVTV 779
             +F  K    +D+                                 + +FD++L A++ +
Sbjct: 1049 QLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMAL 1108

Query: 780  FQILTQEDWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEG 829
            F + T E W  +LY  + S +             S++F+  +    + + N+ V  ++  
Sbjct: 1109 FTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVT 1168

Query: 830  FQAEGDANRSYSDEDQSSSNIEEF 853
            FQ +G+      + D++     E+
Sbjct: 1169 FQEQGEQEYKNCELDKNQRQCVEY 1192



 Score =  103 bits (257), Expect = 2e-21
 Identities = 92/337 (27%), Positives = 154/337 (45%), Gaps = 69/337 (20%)

Query: 586 LCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNI----LEICN 641
           LC  +    R     IV+ K F   I++ I  N V++ I +   PE+ +N     LE   
Sbjct: 105 LCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVE 163

Query: 642 VVFTSMFALEMILKLAAFGLF----DYLRNPYNIFDSIIVIISIWEIV----GQADGG-- 691
            +F  +F +E  LK+ A+GL      YLRN +N+ D IIV++ ++  +     +ADG   
Sbjct: 164 YLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANA 223

Query: 692 ---------LSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFS 742
                    +  LR FR+LR L+LV  +P+L+  L  ++K M  +    +L++  I I++
Sbjct: 224 LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 283

Query: 743 ILGMHIFGCKF----------------------SLRTDTGDTVPDR-------------- 766
           I+G+ +F  K                       +L T  G    +               
Sbjct: 284 IIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGI 343

Query: 767 KNFDSLLWAIVTVFQILTQEDWNVVLY---NGMASTSPWASLYFVALMTFGNYVLFNLLV 823
            NFD+  +A++TVFQ +T E W  VLY   + +    PW  +YFV L+  G++ + NL++
Sbjct: 344 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW--IYFVTLIIIGSFFVLNLVL 401

Query: 824 AILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGL 860
            +L   F  E +  ++  D       + E  +L+E L
Sbjct: 402 GVLSGEFSKEREKAKARGD----FQKLREKQQLEEDL 434



 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 71/243 (29%), Positives = 113/243 (46%), Gaps = 21/243 (8%)

Query: 3    ESASPPSSSAAAPAAEPGVTTEQP--------GPRSPPSSPPGLEEPLDGADPHVPHPDL 54
            +   P  +   +P   P  T E+         GPR  P S   L+E        VP P+ 
Sbjct: 824  DDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKA------VPMPEA 877

Query: 55   APIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKI 114
            +  AFF        R  C ++V +  F  + +  ILL+ ++L    P       S R  I
Sbjct: 878  S--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT---SFRNHI 932

Query: 115  LQVFDDFIFIFFAMEMVLKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN 173
            L   D      F +E++LKM A G F  K  +  + +N LD  +V   ++ + +    IN
Sbjct: 933  LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN 992

Query: 174  LSAI-RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
            +  I R +RVLRPL+AINR   ++ +V  +   +  +GN++++   + F+F  IGVQL+ 
Sbjct: 993  VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1052

Query: 233  GLL 235
            G L
Sbjct: 1053 GKL 1055



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 68/300 (22%), Positives = 136/300 (45%), Gaps = 58/300 (19%)

Query: 1455 DIFITFIICLNVVTMSLE---HYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGL--- 1508
            +I I   I  N V +++      +   +  + L+   Y+F  +F +EA LK++A+GL   
Sbjct: 127  EIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFH 186

Query: 1509 -RRFFKDRWNQLDLAIVLLSVMGITLEEI-EINAALPINPT----IIRIMRVLRIARVLK 1562
               + ++ WN LD  IV++ +    LE+  + + A  +        ++ +R  R+ R L+
Sbjct: 187  PNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLR 246

Query: 1563 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL--VC-------- 1611
            L+     ++ +L+++++A+  + ++ LL + +  IYA +G+ELF GK+   C        
Sbjct: 247  LVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAD 306

Query: 1612 ----NDENPCEGMSRH---------------------ATFENFGMAFLTLFQVSTGDNWN 1646
                +D +PC   + H                       F+NF  A LT+FQ  T + W 
Sbjct: 307  VPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWT 366

Query: 1647 GIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQ 1706
             ++   + D    +            +YFV+ ++   F ++N+V+ VL        ++A+
Sbjct: 367  DVLY-WVNDAVGRDWPW---------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 16/171 (9%)

Query: 75   MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVLK 133
            +V + +FE +  ++ILLN + L M        CL    KI     + +F   F +EM+LK
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHY--GQSCLF---KIAMNILNMLFTGLFTVEMILK 1269

Query: 134  MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-------INLSAIRTVRVLRPL 186
            ++A   F  K Y  D WN  D  IV+  +V+ ++   N       I+++  R  RV+R +
Sbjct: 1270 LIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLV 1326

Query: 187  KAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRN 237
            K ++R   +R L+   + +   L  V LL   +FFI+ +IG+Q++  +  N
Sbjct: 1327 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 7/116 (6%)

Query: 122 IFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD----LQNINLSAI 177
           +   F  EM+LKM +LG+   + Y    +NR D F+V  G++E  L     +  + +S +
Sbjct: 563 LLALFTAEMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619

Query: 178 RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
           R VR+LR  K      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 31/91 (34%), Positives = 55/91 (60%), Gaps = 11/91 (12%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHS-----FYNF-----IYFILLIIVGSFF 388
            +FDN+  A + +F V T EGW E++Y  +D+H+      YN+     I+FI+ II+ +FF
Sbjct: 1097 DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 1156

Query: 389  MINLCLVVIATQFSETKQREHR-LMLEQRQR 418
            M+N+ +  +   F E  ++E++   L++ QR
Sbjct: 1157 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQR 1187


>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
            subunit isoform 12 [Homo sapiens]
          Length = 2146

 Score =  337 bits (864), Expect = 8e-92
 Identities = 205/647 (31%), Positives = 357/647 (55%), Gaps = 52/647 (8%)

Query: 1082 EDEEEIDYTLCFRVRKMIDVY-KPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV 1140
            EDEEE +  +  R R + +++ K     + E  + ++FS  NRFR+ C  I+   +F  +
Sbjct: 846  EDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNL 905

Query: 1141 VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY 1200
            +L FI L+ I++A E P ++  S     L  ++Y+FT+IF  E+ LK+ + G +  + ++
Sbjct: 906  ILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964

Query: 1201 LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1260
             R+ +N+LD  +V VS+I   +  ++      + V+++LR+LR LRPLR I+RA GLK V
Sbjct: 965  CRNYFNILDLLVVSVSLISFGIQSSA------INVVKILRVLRVLRPLRAINRAKGLKHV 1018

Query: 1261 VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANY- 1319
            V+ +  +++ IGNIV++      +F  +GVQLFKGK Y C      +    ++C   NY 
Sbjct: 1019 VQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC---SDSSKQTEAEC-KGNYI 1074

Query: 1320 ---------------RWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQP 1364
                            W + K++FDN+  A+M+LF +++ +GW  ++Y  +D+   D+ P
Sbjct: 1075 TYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1134

Query: 1365 VTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE-EKRLRRLE 1423
            + N+   + ++FI +++I++FF++N+FVG V+  F    Q Q  +E +  E +K  R+  
Sbjct: 1135 IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QEQGEQEYKNCELDKNQRQCV 1190

Query: 1424 KKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETA 1483
            +   KA+ L  Y      +  +  +  S Y +  +  +I LN + ++++HY Q    + A
Sbjct: 1191 EYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIA 1250

Query: 1484 LKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALP 1543
            +   N +FT +F +E +LKL+AF  + +F D WN  D  IV+ S++ I +   E+N A  
Sbjct: 1251 MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEE 1308

Query: 1544 INPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGV 1603
             +   I   R+ R+ R++KLL    G+R LL T +++   +  + LL ++LFFIYA +G+
Sbjct: 1309 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1368

Query: 1604 ELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM-----------KDT 1652
            ++FGK+  ND      ++R+  F+ F  A L LF+ +TG+ W  IM           +  
Sbjct: 1369 QVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1425

Query: 1653 LRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1699
              + T  E  C SS    +  YF+SF +   F++IN+ VAV+M + D
Sbjct: 1426 PSNSTEGETPCGSSF---AVFYFISFYMLCAFLIINLFVAVIMDNFD 1469



 Score =  172 bits (437), Expect = 2e-42
 Identities = 124/404 (30%), Positives = 194/404 (48%), Gaps = 83/404 (20%)

Query: 56  PIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKIL 115
           P A  CL      R  CI +V    FE + +L I  NCV L +Y P  + D  +    + 
Sbjct: 101 PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE 160

Query: 116 QVFDDFIF-IFFAMEMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-- 171
           +V  +++F I F +E  LK++A G+ F    YL + WN LDF IV+ G+    L+     
Sbjct: 161 RV--EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA 218

Query: 172 ------------INLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFV 219
                        ++ A+R  RVLRPL+ ++ VPS+++++N ++  +  L ++ LL  FV
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278

Query: 220 FFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMG 279
             I+ IIG++L+ G +   C+ +E      DV       P EDD  P  C+L        
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGI---ADV-------PAEDDPSP--CAL-------- 318

Query: 280 CHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN 339
                                 + G GRQ  N +           VC+ G   P  G  N
Sbjct: 319 ----------------------ETGHGRQCQNGT-----------VCKPGWDGPKHGITN 345

Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIA 398
           FDN  +A + +FQ IT+EGW +++Y+V DA    + +IYF+ LII+GSFF++NL L V++
Sbjct: 346 FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLS 405

Query: 399 TQFSETKQ-----------REHRLMLEQRQRYLSSSTVASYAEP 431
            +FS+ ++           RE + + E  + YL   T A   +P
Sbjct: 406 GEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 449



 Score =  160 bits (405), Expect = 1e-38
 Identities = 110/358 (30%), Positives = 178/358 (49%), Gaps = 44/358 (12%)

Query: 525 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAV 584
           D  +P  +    S  E   + + AGG+ E +  GAR +   + S+  +            
Sbjct: 457 DEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSR------------ 504

Query: 585 WLCGDVWRE----TRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEIC 640
                 WR      R K R  V S  F   ++  + +NT+++  EH+ QP  LT + +  
Sbjct: 505 -----YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559

Query: 641 NVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG-----QADGGLSVL 695
           N    ++F  EM+LK+ + GL  Y  + +N FD  +V   I E +       +  G+SVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619

Query: 696 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL 755
           R  RLLR+ K+ R+  +L   +  L+ ++ ++A+  +LL LFI IFS+LGM +FG KF+ 
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679

Query: 756 RTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNG-MASTSP-----WASLYFVA 809
                +    R  FD+   +++TVFQILT EDWN V+Y+G MA   P        +YF+ 
Sbjct: 680 ----DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFII 735

Query: 810 LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK 867
           L   GNY+L N+ +AI V+        N + ++   S+   EE +K ++ L  +  P+
Sbjct: 736 LFICGNYILLNVFLAIAVD--------NLADAESLTSAQKEEEEEKERKKLARTASPE 785



 Score =  154 bits (388), Expect = 1e-36
 Identities = 110/348 (31%), Positives = 176/348 (50%), Gaps = 53/348 (15%)

Query: 1121 ENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN-----YI 1175
            +N  R  C +I+  K F+ ++L  IF NC+ +A+  P  E  S      T SN     Y+
Sbjct: 110  KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA----TNSNLERVEYL 165

Query: 1176 FTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLAS-AGGAKILG 1234
            F  IF  E  LKV++ GL F   AYLR+ WN+LD  +V V +   ++  A+ A GA  LG
Sbjct: 166  FLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALG 225

Query: 1235 V------LRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGIL 1288
                   ++ LR  R LRPLR++S  P L++V+ ++I ++ P+ +I L+     II+ I+
Sbjct: 226  GKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAII 285

Query: 1289 GVQLFKGKF----YHCLGVDT-----------------RNITNRSDCMAANYRWVHHKYN 1327
            G++LF GK     Y+  G+                   R   N + C        H   N
Sbjct: 286  GLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITN 345

Query: 1328 FDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV 1387
            FDN   A++++F   + +GW +++Y   DAV  D         W  +YF++ ++I SFFV
Sbjct: 346  FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFV 396

Query: 1388 LNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYY 1435
            LN+ +GV+   F K     E E+A+ R +   ++L +K++  + L  Y
Sbjct: 397  LNLVLGVLSGEFSK-----EREKAKARGD--FQKLREKQQLEEDLKGY 437



 Score =  122 bits (307), Expect = 3e-27
 Identities = 73/259 (28%), Positives = 138/259 (53%), Gaps = 16/259 (6%)

Query: 1458 ITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWN 1517
            + F++ LN +T++ EHYNQP  L       N     +F  E +LK+ + GL+ +F   +N
Sbjct: 530  VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589

Query: 1518 QLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1577
            + D  +V   ++   L E +I     ++P  I ++R +R+ R+ K+ +    +  L+ ++
Sbjct: 590  RFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644

Query: 1578 VQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLF 1637
            + ++  + +L LL  L   I++ LG++LFG     DE      +R +TF+NF  + LT+F
Sbjct: 645  LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM----QTRRSTFDNFPQSLLTVF 700

Query: 1638 QVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKH 1697
            Q+ TG++WN +M D +    +   S    L  +   YF+   +   ++L+NV +A+ + +
Sbjct: 701  QILTGEDWNSVMYDGI--MAYGGPSFPGMLVCI---YFIILFICGNYILLNVFLAIAVDN 755

Query: 1698 LDDSNK--EAQEDAEMDAE 1714
            L D+     AQ++ E + E
Sbjct: 756  LADAESLTSAQKEEEEEKE 774



 Score =  120 bits (300), Expect = 2e-26
 Identities = 94/316 (29%), Positives = 156/316 (49%), Gaps = 38/316 (12%)

Query: 1122 NRF-RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1180
            NRF R  C+  +   +F ++V+  +FLN +TIA E        TE      +N    A+F
Sbjct: 510  NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTE--VQDTANKALLALF 567

Query: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240
              EM LK+ SLGL    QAY  S +N  D F+V   I++ ++          + VLR +R
Sbjct: 568  TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVR 623

Query: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300
            LLR  +  R  +    L  +V +L++S++ I +++L+   F IIF +LG+QLF GKF + 
Sbjct: 624  LLRIFKITRYWN---SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679

Query: 1301 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1360
              + TR  T                  FDN  Q+L+++F + + + W ++MY+G+ A   
Sbjct: 680  DEMQTRRST------------------FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 721

Query: 1361 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCR-----QHQEAEEARRRE 1415
               P       + +YFI   +  ++ +LN+F+ + V+N          Q +E EE  R++
Sbjct: 722  PSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKK 777

Query: 1416 EKRLRRLEKKRRKAQR 1431
              R    EKK+   ++
Sbjct: 778  LARTASPEKKQELVEK 793



 Score =  107 bits (268), Expect = 1e-22
 Identities = 78/303 (25%), Positives = 150/303 (49%), Gaps = 41/303 (13%)

Query: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET-ALKYCNYMFTTVFVLEAV 1500
            RL  H +         I F I L+ ++++ E   Q TS     L   +Y+FT++F LE +
Sbjct: 890  RLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEII 949

Query: 1501 LKLVAFGL----RRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLR 1556
            LK+ A+G       F ++ +N LDL +V +S++   ++   IN        +++I+RVLR
Sbjct: 950  LKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN--------VVKILRVLR 1001

Query: 1557 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL-VCND- 1613
            + R L+ +  A G++ ++  V  A+  +GN+ ++  LL F++A +GV+LF GKL  C+D 
Sbjct: 1002 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061

Query: 1614 ----ENPCEGM--------------------SRHATFENFGMAFLTLFQVSTGDNWNGIM 1649
                E  C+G                     +    F+N   A + LF VST + W  ++
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121

Query: 1650 KDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDA 1709
              ++   T D+    +    +S ++F+ +++   F ++N+ V  ++    +  ++  ++ 
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEIS-IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC 1180

Query: 1710 EMD 1712
            E+D
Sbjct: 1181 ELD 1183



 Score =  107 bits (267), Expect = 1e-22
 Identities = 70/257 (27%), Positives = 131/257 (50%), Gaps = 30/257 (11%)

Query: 601  IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 660
            +V+S YF   + + IL+NT+ + ++H+ Q       + I N++FT +F +EMILKL AF 
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274

Query: 661  LFDYLRNPYNIFDSIIVIISIWEI----VGQADG----GLSVLRTFRLLRVLKLVRFMPA 712
               Y  + +N FD++IV+ SI +I    V  A+      ++  R FR++R++KL+     
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334

Query: 713  LRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSL 772
            +R  L   +K+   +    +L+++  FI++++GM +FG K +L   T   +    NF + 
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIALNDTT--EINRNNNFQTF 1391

Query: 773  LWAIVTVFQILTQEDWNVVLYNGMAST-------------------SPWASLYFVALMTF 813
              A++ +F+  T E W  ++   M                      S +A  YF++    
Sbjct: 1392 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1451

Query: 814  GNYVLFNLLVAILVEGF 830
              +++ NL VA++++ F
Sbjct: 1452 CAFLIINLFVAVIMDNF 1468



 Score =  105 bits (261), Expect = 6e-22
 Identities = 116/564 (20%), Positives = 225/564 (39%), Gaps = 110/564 (19%)

Query: 340  FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF------IYFILLIIVGSFFMINLC 393
            FDN   + + +FQ++T E W  +MY  + A+   +F      IYFI+L I G++ ++N+ 
Sbjct: 689  FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748

Query: 394  LVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRA 453
            L +     ++ +        E+ ++      +A  A P    E +           ++ A
Sbjct: 749  LAIAVDNLADAESLTSAQKEEEEEK--ERKKLARTASPEKKQELV-----------EKPA 795

Query: 454  LGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLAS 513
            +G     +S+ + +  ++       P A +     L P  +  D +P+    P P T   
Sbjct: 796  VG-----ESKEEKIELKSITADGESPPATKINMDDLQPNENE-DKSPY----PNPETTGE 845

Query: 514  DPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 573
            +    P  +   G RP  L                                   SEL  +
Sbjct: 846  EDEEEP--EMPVGPRPRPL-----------------------------------SELHLK 868

Query: 574  EEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEEL 633
            E+     + + +         R +   IV+   F   I+  IL++++S+  E   Q    
Sbjct: 869  EKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSF 928

Query: 634  TN-ILEICNVVFTSMFALEMILKLAAFGLF----DYLRNPYNIFDSIIVIISI--WEIVG 686
             N IL   + VFTS+F LE+ILK+ A+G F     + RN +NI D ++V +S+  + I  
Sbjct: 929  RNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQS 988

Query: 687  QADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGM 746
             A   + +LR  R+LR L+ +     L+  +  +   +  +    ++  L  F+F+ +G+
Sbjct: 989  SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGV 1048

Query: 747  HIFGCKFSLRTDTGDTVP---------------------------DRKNFDSLLWAIVTV 779
             +F  K    +D+                                 + +FD++L A++ +
Sbjct: 1049 QLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMAL 1108

Query: 780  FQILTQEDWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEG 829
            F + T E W  +LY  + S +             S++F+  +    + + N+ V  ++  
Sbjct: 1109 FTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVT 1168

Query: 830  FQAEGDANRSYSDEDQSSSNIEEF 853
            FQ +G+      + D++     E+
Sbjct: 1169 FQEQGEQEYKNCELDKNQRQCVEY 1192



 Score =  103 bits (257), Expect = 2e-21
 Identities = 92/337 (27%), Positives = 154/337 (45%), Gaps = 69/337 (20%)

Query: 586 LCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNI----LEICN 641
           LC  +    R     IV+ K F   I++ I  N V++ I +   PE+ +N     LE   
Sbjct: 105 LCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVE 163

Query: 642 VVFTSMFALEMILKLAAFGLF----DYLRNPYNIFDSIIVIISIWEIV----GQADGG-- 691
            +F  +F +E  LK+ A+GL      YLRN +N+ D IIV++ ++  +     +ADG   
Sbjct: 164 YLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANA 223

Query: 692 ---------LSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFS 742
                    +  LR FR+LR L+LV  +P+L+  L  ++K M  +    +L++  I I++
Sbjct: 224 LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 283

Query: 743 ILGMHIFGCKF----------------------SLRTDTGDTVPDR-------------- 766
           I+G+ +F  K                       +L T  G    +               
Sbjct: 284 IIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGI 343

Query: 767 KNFDSLLWAIVTVFQILTQEDWNVVLY---NGMASTSPWASLYFVALMTFGNYVLFNLLV 823
            NFD+  +A++TVFQ +T E W  VLY   + +    PW  +YFV L+  G++ + NL++
Sbjct: 344 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW--IYFVTLIIIGSFFVLNLVL 401

Query: 824 AILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGL 860
            +L   F  E +  ++  D       + E  +L+E L
Sbjct: 402 GVLSGEFSKEREKAKARGD----FQKLREKQQLEEDL 434



 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 71/243 (29%), Positives = 113/243 (46%), Gaps = 21/243 (8%)

Query: 3    ESASPPSSSAAAPAAEPGVTTEQP--------GPRSPPSSPPGLEEPLDGADPHVPHPDL 54
            +   P  +   +P   P  T E+         GPR  P S   L+E        VP P+ 
Sbjct: 824  DDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKA------VPMPEA 877

Query: 55   APIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKI 114
            +  AFF        R  C ++V +  F  + +  ILL+ ++L    P       S R  I
Sbjct: 878  S--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT---SFRNHI 932

Query: 115  LQVFDDFIFIFFAMEMVLKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN 173
            L   D      F +E++LKM A G F  K  +  + +N LD  +V   ++ + +    IN
Sbjct: 933  LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN 992

Query: 174  LSAI-RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
            +  I R +RVLRPL+AINR   ++ +V  +   +  +GN++++   + F+F  IGVQL+ 
Sbjct: 993  VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1052

Query: 233  GLL 235
            G L
Sbjct: 1053 GKL 1055



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 68/300 (22%), Positives = 136/300 (45%), Gaps = 58/300 (19%)

Query: 1455 DIFITFIICLNVVTMSLE---HYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGL--- 1508
            +I I   I  N V +++      +   +  + L+   Y+F  +F +EA LK++A+GL   
Sbjct: 127  EIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFH 186

Query: 1509 -RRFFKDRWNQLDLAIVLLSVMGITLEEI-EINAALPINPT----IIRIMRVLRIARVLK 1562
               + ++ WN LD  IV++ +    LE+  + + A  +        ++ +R  R+ R L+
Sbjct: 187  PNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLR 246

Query: 1563 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL--VC-------- 1611
            L+     ++ +L+++++A+  + ++ LL + +  IYA +G+ELF GK+   C        
Sbjct: 247  LVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAD 306

Query: 1612 ----NDENPCEGMSRH---------------------ATFENFGMAFLTLFQVSTGDNWN 1646
                +D +PC   + H                       F+NF  A LT+FQ  T + W 
Sbjct: 307  VPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWT 366

Query: 1647 GIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQ 1706
             ++   + D    +            +YFV+ ++   F ++N+V+ VL        ++A+
Sbjct: 367  DVLY-WVNDAVGRDWPW---------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 16/171 (9%)

Query: 75   MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVLK 133
            +V + +FE +  ++ILLN + L M        CL    KI     + +F   F +EM+LK
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHY--GQSCLF---KIAMNILNMLFTGLFTVEMILK 1269

Query: 134  MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-------INLSAIRTVRVLRPL 186
            ++A   F  K Y  D WN  D  IV+  +V+ ++   N       I+++  R  RV+R +
Sbjct: 1270 LIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLV 1326

Query: 187  KAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRN 237
            K ++R   +R L+   + +   L  V LL   +FFI+ +IG+Q++  +  N
Sbjct: 1327 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 7/116 (6%)

Query: 122 IFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD----LQNINLSAI 177
           +   F  EM+LKM +LG+   + Y    +NR D F+V  G++E  L     +  + +S +
Sbjct: 563 LLALFTAEMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619

Query: 178 RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
           R VR+LR  K      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 31/91 (34%), Positives = 55/91 (60%), Gaps = 11/91 (12%)

Query: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHS-----FYNF-----IYFILLIIVGSFF 388
            +FDN+  A + +F V T EGW E++Y  +D+H+      YN+     I+FI+ II+ +FF
Sbjct: 1097 DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 1156

Query: 389  MINLCLVVIATQFSETKQREHR-LMLEQRQR 418
            M+N+ +  +   F E  ++E++   L++ QR
Sbjct: 1157 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQR 1187


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,431,715
Number of Sequences: 37866
Number of extensions: 5229101
Number of successful extensions: 60778
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 248
Number of HSP's successfully gapped in prelim test: 876
Number of HSP's that attempted gapping in prelim test: 41937
Number of HSP's gapped (non-prelim): 14759
length of query: 2188
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2070
effective length of database: 13,779,330
effective search space: 28523213100
effective search space used: 28523213100
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.