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Search of human proteins with 50345870
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
(1198 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 2442 0.0
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 89 2e-17
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 87 9e-17
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 86 2e-16
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 85 4e-16
gi|29788755 SET binding factor 2 [Homo sapiens] 85 5e-16
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 78 6e-14
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 78 6e-14
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 78 6e-14
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 77 1e-13
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 77 1e-13
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 76 2e-13
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 76 2e-13
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 74 6e-13
gi|209863002 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209862998 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209862994 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|18860873 MAP-kinase activating death domain-containing protei... 72 2e-12
gi|209862987 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209862983 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209862979 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209862975 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209862971 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|209571517 MAP-kinase activating death domain-containing prote... 72 2e-12
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 72 2e-12
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 71 7e-12
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 70 2e-11
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 69 2e-11
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 69 2e-11
gi|239735519 SET binding factor 1 [Homo sapiens] 68 5e-11
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 2442 bits (6329), Expect = 0.0
Identities = 1198/1198 (100%), Positives = 1198/1198 (100%)
Query: 1 MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKED 60
MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKED
Sbjct: 1 MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKED 60
Query: 61 CVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYN 120
CVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYN
Sbjct: 61 CVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYN 120
Query: 121 SLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARA 180
SLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARA
Sbjct: 121 SLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARA 180
Query: 181 DPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPL 240
DPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPL
Sbjct: 181 DPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPL 240
Query: 241 QWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTD 300
QWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTD
Sbjct: 241 QWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTD 300
Query: 301 DNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQ 360
DNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQ
Sbjct: 301 DNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQ 360
Query: 361 TTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNR 420
TTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNR
Sbjct: 361 TTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNR 420
Query: 421 RMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIA 480
RMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIA
Sbjct: 421 RMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIA 480
Query: 481 MPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSM 540
MPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSM
Sbjct: 481 MPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSM 540
Query: 541 LSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTV 600
LSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTV
Sbjct: 541 LSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTV 600
Query: 601 ESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQES 660
ESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQES
Sbjct: 601 ESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQES 660
Query: 661 GIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNE 720
GIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNE
Sbjct: 661 GIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNE 720
Query: 721 CVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIP 780
CVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIP
Sbjct: 721 CVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIP 780
Query: 781 TLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAV 840
TLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAV
Sbjct: 781 TLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAV 840
Query: 841 VGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYT 900
VGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYT
Sbjct: 841 VGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYT 900
Query: 901 PGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVW 960
PGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVW
Sbjct: 901 PGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVW 960
Query: 961 VGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVST 1020
VGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVST
Sbjct: 961 VGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVST 1020
Query: 1021 LQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLA 1080
LQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLA
Sbjct: 1021 LQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLA 1080
Query: 1081 FQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGL 1140
FQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGL
Sbjct: 1081 FQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGL 1140
Query: 1141 GQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE 1198
GQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE
Sbjct: 1141 GQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE 1198
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 89.0 bits (219), Expect = 2e-17
Identities = 82/328 (25%), Positives = 132/328 (40%), Gaps = 60/328 (18%)
Query: 45 LCFPGGVCVATE--PKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKT----- 97
LC P G+ T+ P+E H ++T G+RT+G +Y + + +T
Sbjct: 98 LCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMH 157
Query: 98 HRECPGCFVPFA---------------VCVVSRFPYYNSLKDCL--SCLLALLKPCKDFE 140
+ E P A V + RF Y+ +D L S + L+ P +
Sbjct: 158 NAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMK 217
Query: 141 VDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRP 200
+ + + P PPP PL ++ LP P + ++ P++C RP
Sbjct: 218 ACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPP---PGRSLKFSGVYGPIICQRP 274
Query: 201 ---------------------EKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYP 239
E V Q+ TC L E +I+ +S + L V E A ++P
Sbjct: 275 STNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFP 334
Query: 240 LQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSK----EADGLVLINIDHGSITY 295
QWQH +VPIL +L F+ AP +LMG H + ++ SK + L ++ID+ I
Sbjct: 335 FQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIEL 394
Query: 296 SKSTDDNVDIPDVPLLAAQTFIQRVQSL 323
+ D+P P F+Q V +
Sbjct: 395 PE------DLPQFP--NKLEFVQEVSEI 414
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 87.0 bits (214), Expect = 9e-17
Identities = 85/384 (22%), Positives = 156/384 (40%), Gaps = 46/384 (11%)
Query: 66 VLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPF-------------AVCV 112
VLT + YG Q+Y P E H G P +C+
Sbjct: 23 VLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHL---GLLTPVERKMVSKSINTNKCICL 79
Query: 113 VSRFPYYNSLKDCLSCLLAL-LKPCKDFEVDSHIKDFAAKLSLIPSPPPG-PLHLVFNMK 170
+S +P++ + + L + L + ++ HI F + IP P P P LV
Sbjct: 80 LSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHF---MQNIPFPSPQRPRILVQLSV 136
Query: 171 SLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVT 230
++L P+ + L+ PE +L +L E +I+ S A+LT V
Sbjct: 137 HDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVA 196
Query: 231 ECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDH 290
E +A ++P QWQ P++P+ + + AP F++G +F+ D +V I++D
Sbjct: 197 EAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQD-VVCIDLD- 254
Query: 291 GSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSL-----QLHHELHAAHLLSSTDLKEGRA 345
++ Y N++ +P + + ++ L +H + + T ++
Sbjct: 255 TNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEAD-- 312
Query: 346 HRRSWQQK---LNCQIQQTTLQLLVSIFRDVKNHL-----------NYEHRVFNSEEFLK 391
SWQ+K L +IQ+ L+ + SI + + +L +F+ + FLK
Sbjct: 313 --FSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLK 370
Query: 392 TRAPGDHQFYKQVLDTYMFHSFLK 415
+R +FY + T +F F++
Sbjct: 371 SRDRAYAKFYTLLSKTQIFIRFIE 394
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 85.9 bits (211), Expect = 2e-16
Identities = 101/428 (23%), Positives = 176/428 (41%), Gaps = 47/428 (10%)
Query: 24 RAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKED-----CVHFLVLTDVCGNRTYGV 78
R PE ++ A P ++P C P G + P + VLT G++ YG
Sbjct: 218 RYPEEDNEAFPLPE---SVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGA 274
Query: 79 VAQYYRP-----LHDEYCFYNG-----KTHRECPGCFVPF--AVCVVSRFPYYNSLKDCL 126
Q+Y L + G + R G V A+ V+SR+P + + + L
Sbjct: 275 ALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFL 334
Query: 127 SCLLAL-LKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQ-IVLPARADPES 184
+ L + +++HI F + +P P P ++ M ++L
Sbjct: 335 TFLYRYSVSGPHRLPLEAHISHF---IHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPL 391
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
P+ L PE + +L +LTE +++ S LLT V E ++ ++PL WQ
Sbjct: 392 PLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQC 451
Query: 245 PFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSI--TYSKSTDDN 302
P++P+ + D + AP F++G H +F+ AD ++ +++D ++ T K
Sbjct: 452 PYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPAD-VICVDLDTNTLFQTEEKKLLSP 510
Query: 303 VDIPDVP---LLAAQT-FIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQI 358
+P P LLA T Q++ E A+ TD E RR+ +L ++
Sbjct: 511 RTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDY-EAVCGRRA---RLEREV 566
Query: 359 QQTTLQLLVSIFRDVKNHL-----------NYEHRVFNSEEFLKTRAPGDHQFYKQVLDT 407
Q L+ + + + + L +F + FLK+R H+ Y Q+L T
Sbjct: 567 QGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHT 626
Query: 408 YMFHSFLK 415
MF F++
Sbjct: 627 QMFSQFIE 634
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 85.1 bits (209), Expect = 4e-16
Identities = 75/304 (24%), Positives = 119/304 (39%), Gaps = 67/304 (22%)
Query: 45 LCFPGGVCVATEP--KEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDE---------YCFY 93
LC P G+ T+ K+ H ++T G+RTYG V +Y + + Y +
Sbjct: 80 LCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMH 139
Query: 94 NGKTHREC---PGCFVPFAVCV-------------------VSRFPYYNSLKDCLSCLLA 131
N + + C + +SR Y S CL L
Sbjct: 140 NAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLP 199
Query: 132 LLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDL 191
++ CK F + + K PPP PL + ++ LP P + +
Sbjct: 200 FMQACKKFLIQLY------KAVTSQQPPPLPLESYIHNILYEVPLPP---PGRSLKFYGV 250
Query: 192 HLPLLCFRP---------------------EKVLQILTCILTEQRIVFFSSDWALLTLVT 230
+ P++C RP E ++Q+ TC+L E +I+ +S D+ L V
Sbjct: 251 YEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVA 310
Query: 231 ECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSK----EADGLVLI 286
E L+P QWQH +VPIL +L F+ AP +LMG + SK + L +
Sbjct: 311 EGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFV 370
Query: 287 NIDH 290
+ID+
Sbjct: 371 DIDN 374
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 84.7 bits (208), Expect = 5e-16
Identities = 97/410 (23%), Positives = 179/410 (43%), Gaps = 47/410 (11%)
Query: 29 EDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHD 88
+D P G++L C PGG ++ E K+ +VLTD+ +R Y +Y +
Sbjct: 37 DDTPFPQGIELF-----CQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFY----E 87
Query: 89 EYCFYNGKTHRECPG------------CFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPC 136
G E G F P ++ +VSR Y + CL + +
Sbjct: 88 AEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDS 147
Query: 137 KDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKS--LQIVLPARADPESPILDLDLHLP 194
+ ++S I + A L P G +F++ + Q++ D PI + L
Sbjct: 148 LNVSLESLIANLCACLV----PAAGGSQKLFSLGAGDRQLIQTPLHD-SLPITGTSVALL 202
Query: 195 LLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQM 254
+ VL + +LTE +++F S+ + L+ + ++PL++ +P++PIL Q+
Sbjct: 203 FQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQL 262
Query: 255 LDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQ 314
L+ + +PT F++G H +V + D +++ ++D G+I + + +P+ PLL Q
Sbjct: 263 LEVLSSPTPFIIGVHSVFKTDVHELLD-VIIADLDGGTIKIPECIHLS-SLPE-PLL-HQ 318
Query: 315 TFIQRVQSLQLHHELHAA-HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDV 373
T Q SL LH +L A H + +H + L+ +++ L+L +F+
Sbjct: 319 T--QSALSLILHPDLEVADHAFPPP--RTALSH----SKMLDKEVRAVFLRLFAQLFQGY 370
Query: 374 KNHLN----YEHRV--FNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 417
++ L + V F+ FL R ++ F +VL F F+ R
Sbjct: 371 RSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 77.8 bits (190), Expect = 6e-14
Identities = 96/396 (24%), Positives = 157/396 (39%), Gaps = 48/396 (12%)
Query: 39 LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96
L +PQ CFP +E + F+ LT G+R +G Y R L +GK
Sbjct: 739 LKAIPQFCFPDAKDWLPVSEYSSETFSFM-LTGEDGSRRFG----YCRRL-----LPSGK 788
Query: 97 THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156
R +P CV+SR C +L + S + SL+
Sbjct: 789 GPR------LPEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLME 835
Query: 157 SPPPGPLHLV----FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT 212
SP P P + F + VL R +S + +D C ++++I +L
Sbjct: 836 SPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLL 895
Query: 213 EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDH 272
E+R++F + + L+ + +A LYP WQH F+P+L M+D V PT FL+G
Sbjct: 896 ERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSS 955
Query: 273 FEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAA 332
++ KE + ++ GS + + DD + L AA Q+L+ +EL +
Sbjct: 956 LPKL-KELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE-----QALERKNELISQ 1009
Query: 333 HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVFNSEEF 389
S +D LN + + ++ V L R F E F
Sbjct: 1010 DSDSDSD---------DECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAF 1060
Query: 390 LKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRRMDA 424
K+ A +F + +++ MF F++ R R+ A
Sbjct: 1061 RKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRA 1096
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 77.8 bits (190), Expect = 6e-14
Identities = 96/396 (24%), Positives = 157/396 (39%), Gaps = 48/396 (12%)
Query: 39 LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96
L +PQ CFP +E + F+ LT G+R +G Y R L +GK
Sbjct: 739 LKAIPQFCFPDAKDWLPVSEYSSETFSFM-LTGEDGSRRFG----YCRRL-----LPSGK 788
Query: 97 THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156
R +P CV+SR C +L + S + SL+
Sbjct: 789 GPR------LPEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLME 835
Query: 157 SPPPGPLHLV----FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT 212
SP P P + F + VL R +S + +D C ++++I +L
Sbjct: 836 SPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLL 895
Query: 213 EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDH 272
E+R++F + + L+ + +A LYP WQH F+P+L M+D V PT FL+G
Sbjct: 896 ERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSS 955
Query: 273 FEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAA 332
++ KE + ++ GS + + DD + L AA Q+L+ +EL +
Sbjct: 956 LPKL-KELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE-----QALERKNELISQ 1009
Query: 333 HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVFNSEEF 389
S +D LN + + ++ V L R F E F
Sbjct: 1010 DSDSDSD---------DECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAF 1060
Query: 390 LKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRRMDA 424
K+ A +F + +++ MF F++ R R+ A
Sbjct: 1061 RKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRA 1096
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 77.8 bits (190), Expect = 6e-14
Identities = 96/396 (24%), Positives = 157/396 (39%), Gaps = 48/396 (12%)
Query: 39 LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96
L +PQ CFP +E + F+ LT G+R +G Y R L +GK
Sbjct: 319 LKAIPQFCFPDAKDWLPVSEYSSETFSFM-LTGEDGSRRFG----YCRRL-----LPSGK 368
Query: 97 THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156
R +P CV+SR C +L + S + SL+
Sbjct: 369 GPR------LPEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLME 415
Query: 157 SPPPGPLHLV----FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT 212
SP P P + F + VL R +S + +D C ++++I +L
Sbjct: 416 SPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLL 475
Query: 213 EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDH 272
E+R++F + + L+ + +A LYP WQH F+P+L M+D V PT FL+G
Sbjct: 476 ERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSS 535
Query: 273 FEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAA 332
++ KE + ++ GS + + DD + L AA Q+L+ +EL +
Sbjct: 536 LPKL-KELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE-----QALERKNELISQ 589
Query: 333 HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVFNSEEF 389
S +D LN + + ++ V L R F E F
Sbjct: 590 DSDSDSD---------DECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAF 640
Query: 390 LKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRRMDA 424
K+ A +F + +++ MF F++ R R+ A
Sbjct: 641 RKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRA 676
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 76.6 bits (187), Expect = 1e-13
Identities = 72/286 (25%), Positives = 124/286 (43%), Gaps = 32/286 (11%)
Query: 39 LLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTH 98
L TL + CFP V T + VLTD+ + +G +C +
Sbjct: 47 LQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFG------------FC----RLS 90
Query: 99 RECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSP 158
CF C++S P++ + LL +L ++ + L +P P
Sbjct: 91 SGAKSCF-----CILSYLPWF----EVFYKLLNILADYTTKRQENQWNELLETLHKLPIP 141
Query: 159 PPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIV 217
PG +HL ++ S V R P P + +L + +L + +L E+RI+
Sbjct: 142 DPGVSVHL--SVHSYFTVPDTRELPSIPE-NRNLTEYFVAVDVNNMLHLYASMLYERRIL 198
Query: 218 FFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVS 277
S + LT A LYP+ WQH ++P+L +LD+ AP +L+G HL E+V
Sbjct: 199 IICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVR 258
Query: 278 KEA-DGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQS 322
A D +V++N+D + T DD +P+ + + + +++V +
Sbjct: 259 NMALDDVVILNVD--TNTLETPFDDLQSLPNDVISSLKNRLKKVST 302
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 76.6 bits (187), Expect = 1e-13
Identities = 72/286 (25%), Positives = 124/286 (43%), Gaps = 32/286 (11%)
Query: 39 LLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTH 98
L TL + CFP V T + VLTD+ + +G +C +
Sbjct: 47 LQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFG------------FC----RLS 90
Query: 99 RECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSP 158
CF C++S P++ + LL +L ++ + L +P P
Sbjct: 91 SGAKSCF-----CILSYLPWF----EVFYKLLNILADYTTKRQENQWNELLETLHKLPIP 141
Query: 159 PPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIV 217
PG +HL ++ S V R P P + +L + +L + +L E+RI+
Sbjct: 142 DPGVSVHL--SVHSYFTVPDTRELPSIPE-NRNLTEYFVAVDVNNMLHLYASMLYERRIL 198
Query: 218 FFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVS 277
S + LT A LYP+ WQH ++P+L +LD+ AP +L+G HL E+V
Sbjct: 199 IICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVR 258
Query: 278 KEA-DGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQS 322
A D +V++N+D + T DD +P+ + + + +++V +
Sbjct: 259 NMALDDVVILNVD--TNTLETPFDDLQSLPNDVISSLKNRLKKVST 302
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 76.3 bits (186), Expect = 2e-13
Identities = 84/415 (20%), Positives = 160/415 (38%), Gaps = 53/415 (12%)
Query: 41 TLPQLCFPGGVCVATEPKED-----CVHFLVLTDVCGNRTYGVVAQYYRPLHDE------ 89
++P C P G + P VLT + YG Q+Y P +E
Sbjct: 229 SVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQ 288
Query: 90 -----YCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLAL-LKPCKDFEVDS 143
+GK+ +C++S +P++++ + L+ L + ++
Sbjct: 289 RLLLGLTSADGKSDSS-KTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEK 347
Query: 144 HIKDFAAKLSLIPSPPPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEK 202
HI F K +P P P P LV ++L P+ L PE
Sbjct: 348 HISHFMHK---VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPEN 404
Query: 203 VLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 262
+ +L +TE +I+ S ++LT VTE ++ ++P W P+VP+ + D + AP
Sbjct: 405 AVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPC 464
Query: 263 SFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQS 322
F++G +F+ D + +++D +I+ NV +P + + + +
Sbjct: 465 PFIVGIDSRYFDLYDPPPD-VSCVDVDTNTIS-QIGDKKNVAWKILPKKPCKNLMNTLNN 522
Query: 323 LQLHHELHAAH-----------LLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFR 371
LH +L ++ D G+ ++ +IQ+ L + SI +
Sbjct: 523 --LHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR-----LHMIDLEIQEAFLFFMASILK 575
Query: 372 DVKNHL-----------NYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLK 415
+++L +F + FL++R +FY + T MF F++
Sbjct: 576 GYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIE 630
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 76.3 bits (186), Expect = 2e-13
Identities = 84/415 (20%), Positives = 160/415 (38%), Gaps = 53/415 (12%)
Query: 41 TLPQLCFPGGVCVATEPKED-----CVHFLVLTDVCGNRTYGVVAQYYRPLHDE------ 89
++P C P G + P VLT + YG Q+Y P +E
Sbjct: 229 SVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQ 288
Query: 90 -----YCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLAL-LKPCKDFEVDS 143
+GK+ +C++S +P++++ + L+ L + ++
Sbjct: 289 RLLLGLTSADGKSDSS-KTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEK 347
Query: 144 HIKDFAAKLSLIPSPPPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEK 202
HI F K +P P P P LV ++L P+ L PE
Sbjct: 348 HISHFMHK---VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPEN 404
Query: 203 VLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 262
+ +L +TE +I+ S ++LT VTE ++ ++P W P+VP+ + D + AP
Sbjct: 405 AVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPC 464
Query: 263 SFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQS 322
F++G +F+ D + +++D +I+ NV +P + + + +
Sbjct: 465 PFIVGIDSRYFDLYDPPPD-VSCVDVDTNTIS-QIGDKKNVAWKILPKKPCKNLMNTLNN 522
Query: 323 LQLHHELHAAH-----------LLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFR 371
LH +L ++ D G+ ++ +IQ+ L + SI +
Sbjct: 523 --LHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR-----LHMIDLEIQEAFLFFMASILK 575
Query: 372 DVKNHL-----------NYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLK 415
+++L +F + FL++R +FY + T MF F++
Sbjct: 576 GYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIE 630
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 74.3 bits (181), Expect = 6e-13
Identities = 87/386 (22%), Positives = 157/386 (40%), Gaps = 67/386 (17%)
Query: 39 LLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYC-FYNGKT 97
L ++P+ CFP V ++ + VLTD+ + +G +C +G T
Sbjct: 45 LQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFG------------FCRLTSGGT 92
Query: 98 HRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPS 157
+C++S P++ L+ L L E+++ + + L P
Sbjct: 93 ----------ICLCILSYLPWFEVYYKLLNTLADYLAK----ELENDLNETLRSLYNHPV 138
Query: 158 PPPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRI 216
P P++L ++ S I P P +L + +LQ+ +L E+RI
Sbjct: 139 PKANTPVNL--SVHSYFIAPDVTGLPTIPE-SRNLTEYFVAVDVNNMLQLYASMLHERRI 195
Query: 217 VFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 276
V SS + LT A LYP+ WQH ++P+L +LD+ AP +L+G H E V
Sbjct: 196 VIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERV 255
Query: 277 -SKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLL 335
+K + +V++N+D + T D ++P + A + +++
Sbjct: 256 KNKSLEDVVMLNVD--TNTLESPFSDLNNLPSDVVSALKNKLKK---------------- 297
Query: 336 SSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNY---EHRVFNSEEFLKT 392
ST +G + + L+ ++F ++ L Y E F E F+K
Sbjct: 298 QSTATGDG--------------VARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKH 343
Query: 393 RAPGDHQFYKQVLDTYMFHSFLKARL 418
R+ QF + ++ +F F+ RL
Sbjct: 344 RSSVMKQFLETAINLQLFKQFIDGRL 369
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
Query: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
L+ SP P V K + I VLP P
Sbjct: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
Query: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
Query: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 72.4 bits (176), Expect = 2e-12
Identities = 56/220 (25%), Positives = 98/220 (44%), Gaps = 36/220 (16%)
Query: 203 VLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 262
+LQ+ +L E+RIV SS + LT A LYP+ WQH ++P+L +LD+ AP
Sbjct: 202 MLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPM 261
Query: 263 SFLMGCHLDHFEEV-SKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQ 321
+L+G H E V +K + +V++N+D + T D ++P + A + +++
Sbjct: 262 PYLIGIHSSLIERVKNKSLEDVVMLNVD--TNTLESPFSDLNNLPSDVVSALKNKLKK-- 317
Query: 322 SLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNY-- 379
ST +G + + L+ ++F ++ L Y
Sbjct: 318 --------------QSTATGDG--------------VARAFLRAQAALFGSYRDALRYKP 349
Query: 380 -EHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARL 418
E F E F+K R+ QF + ++ +F F+ RL
Sbjct: 350 GEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGRL 389
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 70.9 bits (172), Expect = 7e-12
Identities = 98/430 (22%), Positives = 174/430 (40%), Gaps = 69/430 (16%)
Query: 39 LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96
L +P+ CFP +E K + F VLT G+R +G YC K
Sbjct: 477 LKVIPKFCFPDSKDWMPTSELKSETFSF-VLTGEDGSRWFG------------YC---KK 520
Query: 97 THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156
G +P C+VSR +N S +L ++ ++ + + F + P
Sbjct: 521 LLPVGKGKRLPEVYCMVSRLGCFN----LFSKILDEVEKRREMS-PALVYPFMRSVMEAP 575
Query: 157 SPPPGPLHLVFNM------KSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCI 210
P PG V + +S+++ P +S + +D C ++++ +
Sbjct: 576 FPAPGRTITVKSYLPGAGDESIELCRPL----DSRLEHVDFKCLFKCLSVCHLIRVCASL 631
Query: 211 LTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMG--- 267
L E+R++F ++ + L+ +A LYP WQH ++P+L M+D V +PT FL+G
Sbjct: 632 LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691
Query: 268 CHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHH 327
C L +++ E VLI +D + + + D +I L AA +Q L+ +
Sbjct: 692 CSLPQLQDLPIEE---VLI-VDLCADKFLQEVSDEDEILPPKLQAA-----LMQILEERN 742
Query: 328 ELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVF 384
E+ S D+ LN + + ++ V + ++ RVF
Sbjct: 743 EILTQEQNFSQDV------------TLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVF 790
Query: 385 NSEEFLKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRR--------MDAFAQMDLDTQSE 435
E F K+ F ++T MF F++ R R+ + A ++ +SE
Sbjct: 791 QREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESE 850
Query: 436 EDRINGMLLS 445
+N +L S
Sbjct: 851 PSGMNRILRS 860
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 69.7 bits (169), Expect = 2e-11
Identities = 67/277 (24%), Positives = 115/277 (41%), Gaps = 54/277 (19%)
Query: 42 LPQLCFPGGVCVATEPKEDCV-HF-LVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHR 99
+P+ CFP V EP V HF LTD+ GNR +G +C T
Sbjct: 48 VPKFCFPFDV--EREPPSPAVQHFTFALTDLAGNRRFG------------FCRLRAGTQS 93
Query: 100 ECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDF--------AAK 151
+C++S P++ L+ + LL + E + +++ A
Sbjct: 94 ---------CLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQAS 144
Query: 152 LSL-------------IPSPPPGPLHLVFNMKSLQ-IVLPARADPESPILDLDLHLPLLC 197
+ L IP P G N K L V P S + +L ++
Sbjct: 145 VGLELGSGVTVSSGQGIPPPTRG------NSKPLSCFVAPDSGRLPSIPENRNLTELVVA 198
Query: 198 FRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDF 257
E ++ + +L E+R++ +S + LT A LYP++W+H +P L +LD+
Sbjct: 199 VTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDY 258
Query: 258 VMAPTSFLMGCHLDHFEEVSKEA-DGLVLINIDHGSI 293
AP +L+G H E V ++A + +V++N+D ++
Sbjct: 259 CCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTL 295
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 69.3 bits (168), Expect = 2e-11
Identities = 69/278 (24%), Positives = 110/278 (39%), Gaps = 40/278 (14%)
Query: 39 LLTLPQLCFPGG---VCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNG 95
L +P CFP G + P+E VLT+V G+R G YC
Sbjct: 97 LKAIPLFCFPDGNEWASLTEYPRE--TFSFVLTNVDGSRKIG------------YC---R 139
Query: 96 KTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIK-----DFAA 150
+ PG +P C++S C+ C K + E I F
Sbjct: 140 RLLPAGPGPRLPKVYCIIS----------CIGCFGLFSKILDEVEKRHQISMAVIYPFMQ 189
Query: 151 KLSLIPSPPPGPLHLV--FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILT 208
L P PG + F S + +S + +D L C E++LQI
Sbjct: 190 GLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFA 249
Query: 209 CILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGC 268
+ E++I+F + + L+ A LYP W H ++P++ + +L V PT F++G
Sbjct: 250 SAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGV 309
Query: 269 HLDHFEEV-SKEADGLVLINIDHGSITYSKSTDDNVDI 305
+ +EV + ++L+N+ G T+ S D DI
Sbjct: 310 QMRFQQEVMDSPMEEVLLVNLCEG--TFLMSVGDEKDI 345
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 69.3 bits (168), Expect = 2e-11
Identities = 91/408 (22%), Positives = 157/408 (38%), Gaps = 50/408 (12%)
Query: 39 LLTLPQLCFPGGV-CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKT 97
L +PQ CFP V + VLT G+R +G Y R L GK
Sbjct: 608 LKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFG----YCRRL-----LPGGKG 658
Query: 98 HRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSH--IKDFAAKLSLI 155
R +P C+VSR C S +L + S ++ +
Sbjct: 659 KR------LPEVYCIVSRL-------GCFSLFSRILDEVEKRRGISPALVQPLMRSVMEA 705
Query: 156 PSPPPGPLHLVFNMK--SLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTE 213
P P G LV N S V+ +S + +D ++ + +L E
Sbjct: 706 PFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLE 765
Query: 214 QRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHF 273
+R++F + ++L+ +A +YP WQH ++P+L M+D V +PT FL+G L
Sbjct: 766 RRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGL-LSSS 824
Query: 274 EEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAH 333
+ +E ++ +D + + + DD + + R + L H L +
Sbjct: 825 LPLLRELPLEEVLVVDLVNSRFLRQMDDE-----------DSILPRKLQVALEHILEQRN 873
Query: 334 LLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNY-------EHRVFNS 386
L + + EG R + + + + + V F ++ H + E R
Sbjct: 874 EL-ACEQDEGPLDGRHGPE--SSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQR 930
Query: 387 EEFLKTRAPGDHQFYKQV-LDTYMFHSFLKARLNRRMDAFAQMDLDTQ 433
E F K + + + +V ++T MF F++ R RR DA ++ Q
Sbjct: 931 EAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQ 978
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 68.2 bits (165), Expect = 5e-11
Identities = 101/427 (23%), Positives = 165/427 (38%), Gaps = 57/427 (13%)
Query: 24 RAPEP--EDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQ 81
R PE ED P G++L C P G + E VLTD+ R Y
Sbjct: 30 RFPEKDWEDNPFPQGIELF-----CQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLT 84
Query: 82 YYRPLH--DEYCFYNGKTHRECPG------------------CFVPFAVCVVSRFPYYNS 121
++ P E T RE G F P + +VSR +
Sbjct: 85 FWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSRLDHTEV 144
Query: 122 LKDCLSCLLAL----LKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLP 177
++ L + A+ L C + + + + +P + Q++
Sbjct: 145 FRNSLGLIYAIHVEGLNVCLENVIGNLL------TCTVPLAGGSQRTISLGAGDRQVIQT 198
Query: 178 ARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYL 237
AD P+ + L VL + LTE +++F S + L +A L
Sbjct: 199 PLAD-SLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALL 257
Query: 238 YPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSK 297
+PL++ +VPIL Q+L+ + PT F++G + F+ ++E +++ ++D G++T +
Sbjct: 258 FPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNA-AFQAETQELLDVIVADLDGGTVTIPE 316
Query: 298 STDDNVDIPDVP-LLAAQTFIQRVQSLQLHHELHAAHL------LSSTDLKEGRAHRRSW 350
V IP +P L +QT V S+ L EL A L S++ LK R+
Sbjct: 317 C----VHIPPLPEPLQSQT--HSVLSMVLDPELELADLAFPPPTTSTSSLKMQDKELRAV 370
Query: 351 QQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMF 410
+L Q+ Q L V+ H R F+ FL R + F +VL+ F
Sbjct: 371 FLRLFAQLLQGYRWCL----HVVRIHPEPVIR-FHKAAFLGQRGLVEDDFLMKVLEGMAF 425
Query: 411 HSFLKAR 417
F+ R
Sbjct: 426 AGFVSER 432
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,762,366
Number of Sequences: 37866
Number of extensions: 2323615
Number of successful extensions: 6884
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 6753
Number of HSP's gapped (non-prelim): 184
length of query: 1198
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1084
effective length of database: 13,930,794
effective search space: 15100980696
effective search space used: 15100980696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.