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Search of human proteins with 5031927
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031927 skeletal muscle receptor tyrosine kinase [Homo
sapiens]
(869 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 1763 0.0
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 302 1e-81
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 301 2e-81
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 290 5e-78
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 290 5e-78
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 285 1e-76
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 285 1e-76
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 285 1e-76
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 274 2e-73
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 265 1e-70
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 249 6e-66
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 249 6e-66
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 247 3e-65
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 241 2e-63
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 233 4e-61
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 233 4e-61
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 233 4e-61
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 230 4e-60
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 230 4e-60
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 227 4e-59
gi|62420886 discoidin domain receptor family, member 2 precursor... 226 7e-59
gi|62420884 discoidin domain receptor family, member 2 precursor... 226 7e-59
gi|38327632 discoidin domain receptor family, member 1 isoform b... 226 9e-59
gi|83977450 discoidin domain receptor family, member 1 isoform a... 226 9e-59
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 219 7e-57
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 219 7e-57
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 219 7e-57
gi|83977452 discoidin domain receptor family, member 1 isoform c... 219 9e-57
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 218 1e-56
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 218 1e-56
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 1763 bits (4567), Expect = 0.0
Identities = 869/869 (100%), Positives = 869/869 (100%)
Query: 1 MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEIS 60
MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEIS
Sbjct: 1 MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEIS 60
Query: 61 WTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMK 120
WTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMK
Sbjct: 61 WTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMK 120
Query: 121 PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNV 180
PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNV
Sbjct: 121 PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNV 180
Query: 181 QKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPV 240
QKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPV
Sbjct: 181 QKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPV 240
Query: 241 PTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAAT 300
PTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAAT
Sbjct: 241 PTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAAT 300
Query: 301 ISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELK 360
ISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELK
Sbjct: 301 ISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELK 360
Query: 361 VVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRG 420
VVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRG
Sbjct: 361 VVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRG 420
Query: 421 LYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPS 480
LYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPS
Sbjct: 421 LYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPS 480
Query: 481 SSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLP 540
SSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLP
Sbjct: 481 SSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLP 540
Query: 541 SELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPY 600
SELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPY
Sbjct: 541 SELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPY 600
Query: 601 EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 660
EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY
Sbjct: 601 EPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAY 660
Query: 661 GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK 720
GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK
Sbjct: 661 GDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERK 720
Query: 721 FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT 780
FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT
Sbjct: 721 FVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT 780
Query: 781 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS 840
TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS
Sbjct: 781 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS 840
Query: 841 KLPADRPSFTSIHRILERMCERAEGTVSV 869
KLPADRPSFTSIHRILERMCERAEGTVSV
Sbjct: 841 KLPADRPSFTSIHRILERMCERAEGTVSV 869
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 302 bits (773), Expect = 1e-81
Identities = 224/704 (31%), Positives = 332/704 (47%), Gaps = 96/704 (13%)
Query: 221 HNVT--FGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQ---LFIT 275
+N+T G LHC +G P PTI W +N V + S + + SRL+ L T
Sbjct: 65 NNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTT 124
Query: 276 KPGLYTCIATNKHGEKFSTAKAAATISIAEWSKP----QKDNKGYCAQYRGEVC------ 325
G + C+ATN ST + P + + G+C YRG C
Sbjct: 125 DTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGN 184
Query: 326 ---------------NAVLAKDALVFLNTSYADP--EEAQELLVHTAWNELKVVSPV--- 365
N + A ++ ++ +D + A L H A+ S V
Sbjct: 185 RTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKP 244
Query: 366 ---CRPAAEAL---LCN--HIFQECSPGVVPT-PIPICREYCL--AVKELFCAKEWLVME 414
CR E L LC +IF +P ++ +P C + + + C + + M
Sbjct: 245 RDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMA 304
Query: 415 E---KTHRGL------YRSEMHLL-SVPECSKLPSM--HWDPTACARLPHLD------YN 456
+ K H+ YR + + S +C S H R P L+ N
Sbjct: 305 DPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRN 364
Query: 457 KENLKTFP-----PMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLT 511
N K P DIP S S + M ++ ++ S AI + +
Sbjct: 365 PGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKN-----KMEILYILVPSVAIPLAIA 419
Query: 512 ITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYP 571
+ + C R N+K SA P + + + M PK + E P
Sbjct: 420 LLFFFICVCRN---NQKSSSA-------PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELP 469
Query: 572 RNNIEYVRDIGEGAFGRVFQARA--PGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 629
+ + ++ ++GE AFG++++ PG+ + +VA+K LK+ + +FQ+EA+L
Sbjct: 470 LSAVRFMEELGECAFGKIYKGHLYLPGM---DHAQLVAIKTLKDYNNPQQWTEFQQEASL 526
Query: 630 MAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQV 689
MAE +PNIV LLG +P+C+LFEY+ GDL+EFL SPH SD+ +
Sbjct: 527 MAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPH-------SDVGCSSDE 579
Query: 690 SSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRN 749
L + L IA Q+AAGM YLS FVH+DLA RN L+GE + VKI+D GLSR
Sbjct: 580 DGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSRE 639
Query: 750 IYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHE 809
IYSADYY+ +PIRWMPPE+I Y +++++SD+W++GVVLWEIFS+GLQPYYG +++
Sbjct: 640 IYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQ 699
Query: 810 EVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIH 853
EVI VR +L C E+CP +Y+LM CW+++P+ RP F IH
Sbjct: 700 EVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIH 743
Score = 50.1 bits (118), Expect = 9e-06
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 4/76 (5%)
Query: 123 ITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPL----RENSRIAVLESGSLRIH 178
+ P N+ G A L C GNP P++ W K D+P+ R S + + LRI
Sbjct: 60 LDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIR 119
Query: 179 NVQKEDAGQYRCVAKN 194
N+ D G ++CVA N
Sbjct: 120 NLDTTDTGYFQCVATN 135
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/97 (30%), Positives = 41/97 (42%), Gaps = 3/97 (3%)
Query: 33 PLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIREN--GQLLTILSVE 90
P+ + + + A C V P P I W +N + R S R G L I +++
Sbjct: 63 PMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLD 122
Query: 91 DSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPP 127
+D G + C A NG V S G L VK P T P
Sbjct: 123 TTDTGYFQCVATNG-KEVVSSTGVLFVKFGPPPTASP 158
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 301 bits (771), Expect = 2e-81
Identities = 206/725 (28%), Positives = 321/725 (44%), Gaps = 99/725 (13%)
Query: 211 FARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRL 270
F L + + G LHC G P P + W++N V + ++ SRL
Sbjct: 61 FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL 120
Query: 271 Q---LFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKD------NKGYCAQYR 321
+ L T G Y C+ATN G K TA + + P + G+C YR
Sbjct: 121 RIQDLDTTDTGYYQCVATN--GMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYR 178
Query: 322 GEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQE 381
G C + + + E + T +S C A C+ +F
Sbjct: 179 GIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPL 238
Query: 382 CSP-GVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSM 440
C P P +CR+ C ++ C +E+ + + L +P+C LP
Sbjct: 239 CDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNP------LILMRLQLPKCEALPMP 292
Query: 441 HW-DPTACARLP---------HLDYNKENLKTFPPMTSSKP------------------S 472
D C R+ H YN + +++K S
Sbjct: 293 ESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSS 352
Query: 473 VDIPNLPSSSS----------------------------SSFSVSPTYSMTVIISIMSSF 504
D P L + S S + M ++ ++ S
Sbjct: 353 TDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSI 412
Query: 505 AIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPK 564
AI +++ C R + K L PS+ + MPL+ K
Sbjct: 413 AIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDM-----------EMPLINQHK 461
Query: 565 LLSL-EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADF 623
L E + + ++ ++GE FG+V++ G P E VA+K LK++A ++ +F
Sbjct: 462 QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEF 521
Query: 624 QREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDL 683
+ EA L A +PN+V LLGV +P+ ++F Y ++GDL+EFL SPH+ + D
Sbjct: 522 RHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDR 581
Query: 684 SMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIAD 743
++++ + P + + + Q+AAGM YLS VH+DLATRN LV + + VKI+D
Sbjct: 582 TVKSALEPP--------DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISD 633
Query: 744 FGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPY 803
GL R +Y+ADYYK N +PIRWM PE+I Y +++ +SD+W+YGVVLWE+FSYGLQPY
Sbjct: 634 LGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPY 693
Query: 804 YGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERA 863
G ++++V+ +R+ +L CP++CP +Y LM CW++ P+ RP F IH L RA
Sbjct: 694 CGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL-----RA 748
Query: 864 EGTVS 868
G +S
Sbjct: 749 WGNLS 753
Score = 62.4 bits (150), Expect = 2e-09
Identities = 31/77 (40%), Positives = 46/77 (59%), Gaps = 4/77 (5%)
Query: 126 PPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVL---ESGS-LRIHNVQ 181
P N+ I++G A+L C GNP P+V W+K D+P+ + R ++ E GS LRI ++
Sbjct: 67 PVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLD 126
Query: 182 KEDAGQYRCVAKNSLGT 198
D G Y+CVA N + T
Sbjct: 127 TTDTGYYQCVATNGMKT 143
Score = 43.5 bits (101), Expect = 8e-04
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 3/91 (3%)
Query: 33 PLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIR--ENGQLLTILSVE 90
P+ + + + A C V P P + W +N + R IR E G L I ++
Sbjct: 67 PVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLD 126
Query: 91 DSDDGIYCCTANNGVGGAVESCGALQVKMKP 121
+D G Y C A NG+ + + G L V++ P
Sbjct: 127 TTDTGYYQCVATNGM-KTITATGVLFVRLGP 156
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 290 bits (741), Expect = 5e-78
Identities = 145/303 (47%), Positives = 197/303 (65%), Gaps = 16/303 (5%)
Query: 561 LNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQ 620
L P R+NI R++GEGAFG+VF A L P + +VAVK LK+ AS + +
Sbjct: 524 LKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNAR 582
Query: 621 ADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSH 680
DF REA L+ + +IVK GVC G P+ ++FEYM +GDLN+FLR+ P V
Sbjct: 583 KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV----- 637
Query: 681 SDLSMRAQVSSPGPPP--LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV 738
+ + G PP L+ ++ L IA+Q+AAGM YL+ + FVHRDLATRNCLVGEN++
Sbjct: 638 --------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL 689
Query: 739 VKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSY 798
VKI DFG+SR++YS DYY+ + +PIRWMPPESI Y ++TTESDVW+ GVVLWEIF+Y
Sbjct: 690 VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY 749
Query: 799 GLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILER 858
G QP+Y +++ EVI + G +L P CP E+Y LM CW + P R + IH +L+
Sbjct: 750 GKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
Query: 859 MCE 861
+ +
Sbjct: 810 LAK 812
Score = 51.6 bits (122), Expect = 3e-06
Identities = 53/173 (30%), Positives = 78/173 (45%), Gaps = 19/173 (10%)
Query: 129 NVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAG-Q 187
N+ + EG L C+ G+P P++ W G+ + + + + GSLRI N+ +D+G Q
Sbjct: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQ 263
Query: 188 YRCVAKNSLGTAYSKVVKLEVEVFARI--LRAPESHNVTFGSFVTLHCTATGIPVPTITW 245
CVA+N +G V L V I L +P S + F T G P P + W
Sbjct: 264 ISCVAENLVGEDQDSV-NLTVHFAPTITFLESPTSDHHWCIPF-----TVKGNPKPALQW 317
Query: 246 IENGNAVSSGSIQESVKDRVIDSR-----LQL---FITKPGLYTCIATNKHGE 290
NG A+ + S K V + LQL G YT IA N++G+
Sbjct: 318 FYNG-AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/206 (26%), Positives = 82/206 (39%), Gaps = 34/206 (16%)
Query: 6 NIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEE--VATFMCAVESYPQPEISWTR 63
NIPL ++ ++P + + L + VEE T C+V P P + W
Sbjct: 183 NIPLANL----------QIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV 232
Query: 64 NKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKI 123
++ K + S + +T +S +DS I C A N VG +S L V P I
Sbjct: 233 GNLVSKHMNET-SHTQGSLRITNISSDDSGKQI-SCVAENLVGEDQDSVN-LTVHFAPTI 289
Query: 124 TRPPINVKIIEGLKA----VLPCTTMGNPKPSVSWIKGDSPLRENSRIAVL--------E 171
T +E + +P T GNPKP++ W + L E+ I
Sbjct: 290 T-------FLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
Query: 172 SGSLRIHNVQKEDAGQYRCVAKNSLG 197
G L++ N + G Y +AKN G
Sbjct: 343 HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 290 bits (741), Expect = 5e-78
Identities = 145/303 (47%), Positives = 197/303 (65%), Gaps = 16/303 (5%)
Query: 561 LNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQ 620
L P R+NI R++GEGAFG+VF A L P + +VAVK LK+ AS + +
Sbjct: 540 LKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNAR 598
Query: 621 ADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSH 680
DF REA L+ + +IVK GVC G P+ ++FEYM +GDLN+FLR+ P V
Sbjct: 599 KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV----- 653
Query: 681 SDLSMRAQVSSPGPPP--LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV 738
+ + G PP L+ ++ L IA+Q+AAGM YL+ + FVHRDLATRNCLVGEN++
Sbjct: 654 --------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL 705
Query: 739 VKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSY 798
VKI DFG+SR++YS DYY+ + +PIRWMPPESI Y ++TTESDVW+ GVVLWEIF+Y
Sbjct: 706 VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY 765
Query: 799 GLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILER 858
G QP+Y +++ EVI + G +L P CP E+Y LM CW + P R + IH +L+
Sbjct: 766 GKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 825
Query: 859 MCE 861
+ +
Sbjct: 826 LAK 828
Score = 51.6 bits (122), Expect = 3e-06
Identities = 53/173 (30%), Positives = 78/173 (45%), Gaps = 19/173 (10%)
Query: 129 NVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAG-Q 187
N+ + EG L C+ G+P P++ W G+ + + + + GSLRI N+ +D+G Q
Sbjct: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQ 263
Query: 188 YRCVAKNSLGTAYSKVVKLEVEVFARI--LRAPESHNVTFGSFVTLHCTATGIPVPTITW 245
CVA+N +G V L V I L +P S + F T G P P + W
Sbjct: 264 ISCVAENLVGEDQDSV-NLTVHFAPTITFLESPTSDHHWCIPF-----TVKGNPKPALQW 317
Query: 246 IENGNAVSSGSIQESVKDRVIDSR-----LQL---FITKPGLYTCIATNKHGE 290
NG A+ + S K V + LQL G YT IA N++G+
Sbjct: 318 FYNG-AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/206 (26%), Positives = 82/206 (39%), Gaps = 34/206 (16%)
Query: 6 NIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEE--VATFMCAVESYPQPEISWTR 63
NIPL ++ ++P + + L + VEE T C+V P P + W
Sbjct: 183 NIPLANL----------QIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV 232
Query: 64 NKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKI 123
++ K + S + +T +S +DS I C A N VG +S L V P I
Sbjct: 233 GNLVSKHMNET-SHTQGSLRITNISSDDSGKQI-SCVAENLVGEDQDSVN-LTVHFAPTI 289
Query: 124 TRPPINVKIIEGLKA----VLPCTTMGNPKPSVSWIKGDSPLRENSRIAVL--------E 171
T +E + +P T GNPKP++ W + L E+ I
Sbjct: 290 T-------FLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
Query: 172 SGSLRIHNVQKEDAGQYRCVAKNSLG 197
G L++ N + G Y +AKN G
Sbjct: 343 HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 285 bits (730), Expect = 1e-76
Identities = 143/290 (49%), Positives = 186/290 (64%), Gaps = 10/290 (3%)
Query: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
R +I ++GEGAFG+VF A LLP + +VAVK LKE AS + DFQREA L+
Sbjct: 501 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLT 559
Query: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
+ +IV+ GVC G+P+ ++FEYM +GDLN FLRS P D + A
Sbjct: 560 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---------DAKLLAGGED 610
Query: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
P PL + L +A QVAAGM YL+ FVHRDLATRNCLVG+ +VVKI DFG+SR+IY
Sbjct: 611 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 670
Query: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
S DYY+ +PIRWMPPESI Y ++TTESDVW++GVVLWEIF+YG QP+Y +++ E
Sbjct: 671 STDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 730
Query: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861
I + G L P CP E+Y +MR CW + P R S +H L+ + +
Sbjct: 731 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 780
Score = 35.0 bits (79), Expect = 0.30
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQL----LT 85
+ P +VD V + C VE + W IL +L + ++ ++G L LT
Sbjct: 198 VQVPNASVD--VGDDVLLRCQVEGRGLEQAGW----ILTEL-EQSATVMKSGGLPSLGLT 250
Query: 86 ILSV-EDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKI---IEGLKAVLP 141
+ +V D + C A N VG A S +QV + P +V++ +E +P
Sbjct: 251 LANVTSDLNRKNVTCWAENDVGRAEVS---VQVNVSF-----PASVQLHTAVEMHHWCIP 302
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRI----------AVLESGSLRIHNVQKEDAGQYRCV 191
+ G P PS+ W+ S L E S I + G LR++ + G Y +
Sbjct: 303 FSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLL 362
Query: 192 AKNSLGTAYSKVV 204
A N G A + ++
Sbjct: 363 AANPFGQASASIM 375
Score = 33.9 bits (76), Expect = 0.67
Identities = 43/201 (21%), Positives = 80/201 (39%), Gaps = 26/201 (12%)
Query: 111 SCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV- 169
SCG +K++ N + G +L C G WI + L +++ +
Sbjct: 190 SCGVPTLKVQVP------NASVDVGDDVLLRCQVEGRGLEQAGWILTE--LEQSATVMKS 241
Query: 170 --LESGSLRIHNVQKE-DAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
L S L + NV + + C A+N +G A ++ V+V + + H
Sbjct: 242 GGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-----EVSVQVNVSFPASVQLHTAVEM 296
Query: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGS------IQESVKDRVIDSRLQL---FITKP 277
+ + G P P++ W+ NG+ ++ S ++ + + V L+L
Sbjct: 297 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
Query: 278 GLYTCIATNKHGEKFSTAKAA 298
G YT +A N G+ ++ AA
Sbjct: 357 GNYTLLAANPFGQASASIMAA 377
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 285 bits (730), Expect = 1e-76
Identities = 143/290 (49%), Positives = 186/290 (64%), Gaps = 10/290 (3%)
Query: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
R +I ++GEGAFG+VF A LLP + +VAVK LKE AS + DFQREA L+
Sbjct: 507 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLT 565
Query: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
+ +IV+ GVC G+P+ ++FEYM +GDLN FLRS P D + A
Sbjct: 566 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---------DAKLLAGGED 616
Query: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
P PL + L +A QVAAGM YL+ FVHRDLATRNCLVG+ +VVKI DFG+SR+IY
Sbjct: 617 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 676
Query: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
S DYY+ +PIRWMPPESI Y ++TTESDVW++GVVLWEIF+YG QP+Y +++ E
Sbjct: 677 STDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 736
Query: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861
I + G L P CP E+Y +MR CW + P R S +H L+ + +
Sbjct: 737 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 786
Score = 35.0 bits (79), Expect = 0.30
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQL----LT 85
+ P +VD V + C VE + W IL +L + ++ ++G L LT
Sbjct: 198 VQVPNASVD--VGDDVLLRCQVEGRGLEQAGW----ILTEL-EQSATVMKSGGLPSLGLT 250
Query: 86 ILSV-EDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKI---IEGLKAVLP 141
+ +V D + C A N VG A S +QV + P +V++ +E +P
Sbjct: 251 LANVTSDLNRKNVTCWAENDVGRAEVS---VQVNVSF-----PASVQLHTAVEMHHWCIP 302
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRI----------AVLESGSLRIHNVQKEDAGQYRCV 191
+ G P PS+ W+ S L E S I + G LR++ + G Y +
Sbjct: 303 FSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLL 362
Query: 192 AKNSLGTAYSKVV 204
A N G A + ++
Sbjct: 363 AANPFGQASASIM 375
Score = 33.9 bits (76), Expect = 0.67
Identities = 43/201 (21%), Positives = 80/201 (39%), Gaps = 26/201 (12%)
Query: 111 SCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV- 169
SCG +K++ N + G +L C G WI + L +++ +
Sbjct: 190 SCGVPTLKVQVP------NASVDVGDDVLLRCQVEGRGLEQAGWILTE--LEQSATVMKS 241
Query: 170 --LESGSLRIHNVQKE-DAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
L S L + NV + + C A+N +G A ++ V+V + + H
Sbjct: 242 GGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-----EVSVQVNVSFPASVQLHTAVEM 296
Query: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGS------IQESVKDRVIDSRLQL---FITKP 277
+ + G P P++ W+ NG+ ++ S ++ + + V L+L
Sbjct: 297 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
Query: 278 GLYTCIATNKHGEKFSTAKAA 298
G YT +A N G+ ++ AA
Sbjct: 357 GNYTLLAANPFGQASASIMAA 377
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 285 bits (730), Expect = 1e-76
Identities = 143/290 (49%), Positives = 186/290 (64%), Gaps = 10/290 (3%)
Query: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
R +I ++GEGAFG+VF A LLP + +VAVK LKE AS + DFQREA L+
Sbjct: 471 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLT 529
Query: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
+ +IV+ GVC G+P+ ++FEYM +GDLN FLRS P D + A
Sbjct: 530 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---------DAKLLAGGED 580
Query: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
P PL + L +A QVAAGM YL+ FVHRDLATRNCLVG+ +VVKI DFG+SR+IY
Sbjct: 581 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 640
Query: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
S DYY+ +PIRWMPPESI Y ++TTESDVW++GVVLWEIF+YG QP+Y +++ E
Sbjct: 641 STDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 700
Query: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861
I + G L P CP E+Y +MR CW + P R S +H L+ + +
Sbjct: 701 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 750
Score = 35.0 bits (79), Expect = 0.30
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQL----LT 85
+ P +VD V + C VE + W IL +L + ++ ++G L LT
Sbjct: 168 VQVPNASVD--VGDDVLLRCQVEGRGLEQAGW----ILTEL-EQSATVMKSGGLPSLGLT 220
Query: 86 ILSV-EDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKI---IEGLKAVLP 141
+ +V D + C A N VG A S +QV + P +V++ +E +P
Sbjct: 221 LANVTSDLNRKNVTCWAENDVGRAEVS---VQVNVSF-----PASVQLHTAVEMHHWCIP 272
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRI----------AVLESGSLRIHNVQKEDAGQYRCV 191
+ G P PS+ W+ S L E S I + G LR++ + G Y +
Sbjct: 273 FSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLL 332
Query: 192 AKNSLGTAYSKVV 204
A N G A + ++
Sbjct: 333 AANPFGQASASIM 345
Score = 33.9 bits (76), Expect = 0.67
Identities = 43/201 (21%), Positives = 80/201 (39%), Gaps = 26/201 (12%)
Query: 111 SCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV- 169
SCG +K++ N + G +L C G WI + L +++ +
Sbjct: 160 SCGVPTLKVQVP------NASVDVGDDVLLRCQVEGRGLEQAGWILTE--LEQSATVMKS 211
Query: 170 --LESGSLRIHNVQKE-DAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
L S L + NV + + C A+N +G A ++ V+V + + H
Sbjct: 212 GGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-----EVSVQVNVSFPASVQLHTAVEM 266
Query: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGS------IQESVKDRVIDSRLQL---FITKP 277
+ + G P P++ W+ NG+ ++ S ++ + + V L+L
Sbjct: 267 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 326
Query: 278 GLYTCIATNKHGEKFSTAKAA 298
G YT +A N G+ ++ AA
Sbjct: 327 GNYTLLAANPFGQASASIMAA 347
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 274 bits (701), Expect = 2e-73
Identities = 133/288 (46%), Positives = 189/288 (65%), Gaps = 9/288 (3%)
Query: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
R +I R++GEGAFG+VF A L P + +VAVK LK+ A + DFQREA L+
Sbjct: 535 RRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA-ARKDFQREAELLT 593
Query: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
+ +IVK GVC G P+ ++FEYM +GDLN+FLR+ P + + + +
Sbjct: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE--- 650
Query: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
L ++ L IA Q+A+GM YL+ + FVHRDLATRNCLVG N++VKI DFG+SR++Y
Sbjct: 651 -----LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 705
Query: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
S DYY+ + +PIRWMPPESI Y ++TTESDVW++GV+LWEIF+YG QP++ +++ EV
Sbjct: 706 STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV 765
Query: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
I + G +L P CP E+Y++M CW + P R + I++IL +
Sbjct: 766 IECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 813
Score = 53.5 bits (127), Expect = 8e-07
Identities = 55/186 (29%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 121 PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWI----KGDSPLRENSRIAVLESGSLR 176
P+I+ +N+ + EG AV+ C G+P P V WI + + + N + + +L
Sbjct: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
Query: 177 IHNVQKEDAG-QYRCVAKNSLGTAYSKVVKLEVEVFARI--LRAPE---SHNVTFGSFVT 230
+ NV ED G C+A+N +G + + V L V R+ L PE H + F
Sbjct: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVA-LTVYYPPRVVSLEEPELRLEHCIEF----- 323
Query: 231 LHCTATGIPVPTITWIENGNAVSSGSI--QESVKDRVIDSRLQLFITKP-----GLYTCI 283
G P PT+ W+ NG + I E ++ I LF KP G YT I
Sbjct: 324 ---VVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLI 379
Query: 284 ATNKHG 289
A N G
Sbjct: 380 AKNPLG 385
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/168 (27%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 45 ATFMCAVESYPQPEISWTRNKIL-IKLFDTRYSIRENGQL-LTILSVEDSDDGI-YCCTA 101
A C P P++ W + I T + + LT+++V D+G C A
Sbjct: 227 AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286
Query: 102 NNGVGGAVESCGALQVKMKPKIT---RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGD 158
N VG + S AL V P++ P + L+ + GNP P++ W+
Sbjct: 287 ENVVGMSNASV-ALTVYYPPRVVSLEEPELR------LEHCIEFVVRGNPPPTLHWLHNG 339
Query: 159 SPLRENSRIAV-------LESGSLRIHNVQKEDAGQYRCVAKNSLGTA 199
PLRE+ I V + G L + + G Y +AKN LGTA
Sbjct: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 265 bits (677), Expect = 1e-70
Identities = 135/302 (44%), Positives = 191/302 (63%), Gaps = 23/302 (7%)
Query: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
R +I R++GEGAFG+VF A L P + +VAVK LK+ A + DFQREA L+
Sbjct: 535 RRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA-ARKDFQREAELLT 593
Query: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
+ +IVK GVC G P+ ++FEYM +GDLN+FLR+ P + + + +
Sbjct: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE--- 650
Query: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
L ++ L IA Q+A+GM YL+ + FVHRDLATRNCLVG N++VKI DFG+SR++Y
Sbjct: 651 -----LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 705
Query: 752 SADYYKA---NEND-----------AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFS 797
S DYY+ + ND +PIRWMPPESI Y ++TTESDVW++GV+LWEIF+
Sbjct: 706 STDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 765
Query: 798 YGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILE 857
YG QP++ +++ EVI + G +L P CP E+Y++M CW + P R + I++IL
Sbjct: 766 YGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILH 825
Query: 858 RM 859
+
Sbjct: 826 AL 827
Score = 53.5 bits (127), Expect = 8e-07
Identities = 55/186 (29%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 121 PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWI----KGDSPLRENSRIAVLESGSLR 176
P+I+ +N+ + EG AV+ C G+P P V WI + + + N + + +L
Sbjct: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
Query: 177 IHNVQKEDAG-QYRCVAKNSLGTAYSKVVKLEVEVFARI--LRAPE---SHNVTFGSFVT 230
+ NV ED G C+A+N +G + + V L V R+ L PE H + F
Sbjct: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVA-LTVYYPPRVVSLEEPELRLEHCIEF----- 323
Query: 231 LHCTATGIPVPTITWIENGNAVSSGSI--QESVKDRVIDSRLQLFITKP-----GLYTCI 283
G P PT+ W+ NG + I E ++ I LF KP G YT I
Sbjct: 324 ---VVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLI 379
Query: 284 ATNKHG 289
A N G
Sbjct: 380 AKNPLG 385
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/168 (27%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 45 ATFMCAVESYPQPEISWTRNKIL-IKLFDTRYSIRENGQL-LTILSVEDSDDGI-YCCTA 101
A C P P++ W + I T + + LT+++V D+G C A
Sbjct: 227 AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286
Query: 102 NNGVGGAVESCGALQVKMKPKIT---RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGD 158
N VG + S AL V P++ P + L+ + GNP P++ W+
Sbjct: 287 ENVVGMSNASV-ALTVYYPPRVVSLEEPELR------LEHCIEFVVRGNPPPTLHWLHNG 339
Query: 159 SPLRENSRIAV-------LESGSLRIHNVQKEDAGQYRCVAKNSLGTA 199
PLRE+ I V + G L + + G Y +AKN LGTA
Sbjct: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 249 bits (637), Expect = 6e-66
Identities = 122/289 (42%), Positives = 181/289 (62%), Gaps = 14/289 (4%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
E R I +R++G+G+FG V++ A ++ E T VAVK + E AS + +F EA+
Sbjct: 1005 EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEAS 1064
Query: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
+M F ++V+LLGV + G+P ++ E MA+GDL +LRS+ P
Sbjct: 1065 VMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE------------- 1111
Query: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
++PG PP + E + +A ++A GMAYL+ +KFVHRDLA RNC+V + VKI DFG++R
Sbjct: 1112 -NNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR 1170
Query: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
+IY DYY+ +P+RWM PES+ +TT SD+W++GVVLWEI S QPY G+++
Sbjct: 1171 DIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN 1230
Query: 809 EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILE 857
E+V+ +V DG L P+NCP + +LMR+CW P RP+F I +L+
Sbjct: 1231 EQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 249 bits (637), Expect = 6e-66
Identities = 122/289 (42%), Positives = 181/289 (62%), Gaps = 14/289 (4%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
E R I +R++G+G+FG V++ A ++ E T VAVK + E AS + +F EA+
Sbjct: 1017 EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEAS 1076
Query: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
+M F ++V+LLGV + G+P ++ E MA+GDL +LRS+ P
Sbjct: 1077 VMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE------------- 1123
Query: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
++PG PP + E + +A ++A GMAYL+ +KFVHRDLA RNC+V + VKI DFG++R
Sbjct: 1124 -NNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR 1182
Query: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
+IY DYY+ +P+RWM PES+ +TT SD+W++GVVLWEI S QPY G+++
Sbjct: 1183 DIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN 1242
Query: 809 EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILE 857
E+V+ +V DG L P+NCP + +LMR+CW P RP+F I +L+
Sbjct: 1243 EQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 247 bits (631), Expect = 3e-65
Identities = 122/284 (42%), Positives = 179/284 (63%), Gaps = 14/284 (4%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
E R I R++G+G+FG V++ A G++ EP T VA+K + E AS + +F EA+
Sbjct: 993 EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052
Query: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
+M EF+ ++V+LLGV + G+P ++ E M GDL +LRS+ P
Sbjct: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE--------------M 1098
Query: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
++P P S ++ + +A ++A GMAYL+ KFVHRDLA RNC+V E+ VKI DFG++R
Sbjct: 1099 ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTR 1158
Query: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
+IY DYY+ +P+RWM PES+ +TT SDVW++GVVLWEI + QPY G+++
Sbjct: 1159 DIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSN 1218
Query: 809 EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
E+V+ +V +G +L P+NCP L+ LMR+CW P RPSF I
Sbjct: 1219 EQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 241 bits (616), Expect = 2e-63
Identities = 121/284 (42%), Positives = 174/284 (61%), Gaps = 14/284 (4%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
E PR I +R++G+G+FG V++ A GL E T VA+K + E AS +F +EA+
Sbjct: 973 EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEAS 1032
Query: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
+M F ++V+LLGV + G+P ++ E M GDL LRS+ P
Sbjct: 1033 VMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE------------- 1079
Query: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
++PG P + E + +A ++A GMAYL+ KFVHRDLA RNC+V ++ VKI DFG++R
Sbjct: 1080 -NNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTR 1138
Query: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
++Y DYY+ +P+RWM PES+ +TT SDVW++GVVLWEI + QPY G+++
Sbjct: 1139 DVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSN 1198
Query: 809 EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
E+V+ +V DG +L E CP++L LM CW P RPSFT I
Sbjct: 1199 EQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI 1242
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 233 bits (595), Expect = 4e-61
Identities = 129/294 (43%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--FTMVAVKMLKEEASADMQADFQRE 626
E+PR+ + + +GEG FG+V +A A G+ P P + VAVKMLK+ AS AD E
Sbjct: 421 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 480
Query: 627 AALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSM 685
+M + NI+ LLGVC P+ ++ E A G+L EFLR+ P DLS
Sbjct: 481 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRP------PGPDLSP 534
Query: 686 RAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 745
SS GP LS + A QVA GM YL RK +HRDLA RN LV E+ V+KIADFG
Sbjct: 535 DGPRSSEGP--LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG 592
Query: 746 LSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 805
L+R ++ DYYK N +P++WM PE++F YT +SDVW++G++LWEIF+ G PY G
Sbjct: 593 LARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 652
Query: 806 MAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
+ EE+ +R+G+ + P +CP ELY LMR CW P+ RP+F + L+++
Sbjct: 653 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 706
Score = 55.1 bits (131), Expect = 3e-07
Identities = 49/176 (27%), Positives = 70/176 (39%), Gaps = 24/176 (13%)
Query: 47 FMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQ--LLTILSVEDSDDGIYCCTANNG 104
F C P P I W ++ + IR Q L + SV SD G Y C N
Sbjct: 170 FRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENA 229
Query: 105 VGGAVESCGALQVKMKPKITRP------PINVKIIEGLKAVLPCTTMGNPKPSVSWIK-- 156
VG + ++ P RP P N + G L C + +P + W+K
Sbjct: 230 VGSIRYNYLLDVLERSPH--RPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHI 287
Query: 157 ---GDS------PLRENSRIAVLESGSLRI---HNVQKEDAGQYRCVAKNSLGTAY 200
G S P + + A + S + + NV EDAG+Y C+A NS+G +Y
Sbjct: 288 VINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSY 343
Score = 40.4 bits (93), Expect = 0.007
Identities = 47/206 (22%), Positives = 74/206 (35%), Gaps = 35/206 (16%)
Query: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174
L+ + P + + + + G L C G + W K S L R+ G
Sbjct: 30 LEPCLAPSLEQQEQELTVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWR-GR 85
Query: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYS-------KVVKLEVEVFARILRAPES------- 220
L I + EDAG+Y C+A+ S+ + + + + R P +
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 221 --------------HNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVI 266
H V G+ V C A G P PTI W+++G A + ++ R
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 267 DSRLQLFITKP---GLYTCIATNKHG 289
L + P G YTC+ N G
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVG 231
Score = 34.7 bits (78), Expect = 0.39
Identities = 24/103 (23%), Positives = 43/103 (41%), Gaps = 13/103 (12%)
Query: 22 EKLPKAPVITTPLET-VDALVEEVATFMCAVESYPQPEISWTRNKIL------------I 68
E+ P P++ L A+V +C V S QP I W ++ ++ +
Sbjct: 243 ERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYV 302
Query: 69 KLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVES 111
++ T ++L + +V D G Y C A N +G + +S
Sbjct: 303 QVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 233 bits (595), Expect = 4e-61
Identities = 129/294 (43%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--FTMVAVKMLKEEASADMQADFQRE 626
E+PR+ + + +GEG FG+V +A A G+ P P + VAVKMLK+ AS AD E
Sbjct: 461 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 520
Query: 627 AALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSM 685
+M + NI+ LLGVC P+ ++ E A G+L EFLR+ P DLS
Sbjct: 521 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRP------PGPDLSP 574
Query: 686 RAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 745
SS GP LS + A QVA GM YL RK +HRDLA RN LV E+ V+KIADFG
Sbjct: 575 DGPRSSEGP--LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG 632
Query: 746 LSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 805
L+R ++ DYYK N +P++WM PE++F YT +SDVW++G++LWEIF+ G PY G
Sbjct: 633 LARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 692
Query: 806 MAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
+ EE+ +R+G+ + P +CP ELY LMR CW P+ RP+F + L+++
Sbjct: 693 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 746
Score = 55.1 bits (131), Expect = 3e-07
Identities = 49/176 (27%), Positives = 70/176 (39%), Gaps = 24/176 (13%)
Query: 47 FMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQ--LLTILSVEDSDDGIYCCTANNG 104
F C P P I W ++ + IR Q L + SV SD G Y C N
Sbjct: 170 FRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENA 229
Query: 105 VGGAVESCGALQVKMKPKITRP------PINVKIIEGLKAVLPCTTMGNPKPSVSWIK-- 156
VG + ++ P RP P N + G L C + +P + W+K
Sbjct: 230 VGSIRYNYLLDVLERSPH--RPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHI 287
Query: 157 ---GDS------PLRENSRIAVLESGSLRI---HNVQKEDAGQYRCVAKNSLGTAY 200
G S P + + A + S + + NV EDAG+Y C+A NS+G +Y
Sbjct: 288 VINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSY 343
Score = 40.4 bits (93), Expect = 0.007
Identities = 47/206 (22%), Positives = 74/206 (35%), Gaps = 35/206 (16%)
Query: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174
L+ + P + + + + G L C G + W K S L R+ G
Sbjct: 30 LEPCLAPSLEQQEQELTVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWR-GR 85
Query: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYS-------KVVKLEVEVFARILRAPES------- 220
L I + EDAG+Y C+A+ S+ + + + + R P +
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 221 --------------HNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVI 266
H V G+ V C A G P PTI W+++G A + ++ R
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 267 DSRLQLFITKP---GLYTCIATNKHG 289
L + P G YTC+ N G
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVG 231
Score = 34.7 bits (78), Expect = 0.39
Identities = 24/103 (23%), Positives = 43/103 (41%), Gaps = 13/103 (12%)
Query: 22 EKLPKAPVITTPLET-VDALVEEVATFMCAVESYPQPEISWTRNKIL------------I 68
E+ P P++ L A+V +C V S QP I W ++ ++ +
Sbjct: 243 ERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYV 302
Query: 69 KLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVES 111
++ T ++L + +V D G Y C A N +G + +S
Sbjct: 303 QVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 233 bits (595), Expect = 4e-61
Identities = 129/294 (43%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--FTMVAVKMLKEEASADMQADFQRE 626
E+PR+ + + +GEG FG+V +A A G+ P P + VAVKMLK+ AS AD E
Sbjct: 461 EFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSE 520
Query: 627 AALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSM 685
+M + NI+ LLGVC P+ ++ E A G+L EFLR+ P DLS
Sbjct: 521 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRP------PGPDLSP 574
Query: 686 RAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 745
SS GP LS + A QVA GM YL RK +HRDLA RN LV E+ V+KIADFG
Sbjct: 575 DGPRSSEGP--LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG 632
Query: 746 LSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 805
L+R ++ DYYK N +P++WM PE++F YT +SDVW++G++LWEIF+ G PY G
Sbjct: 633 LARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 692
Query: 806 MAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
+ EE+ +R+G+ + P +CP ELY LMR CW P+ RP+F + L+++
Sbjct: 693 IPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 746
Score = 55.1 bits (131), Expect = 3e-07
Identities = 49/176 (27%), Positives = 70/176 (39%), Gaps = 24/176 (13%)
Query: 47 FMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQ--LLTILSVEDSDDGIYCCTANNG 104
F C P P I W ++ + IR Q L + SV SD G Y C N
Sbjct: 170 FRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENA 229
Query: 105 VGGAVESCGALQVKMKPKITRP------PINVKIIEGLKAVLPCTTMGNPKPSVSWIK-- 156
VG + ++ P RP P N + G L C + +P + W+K
Sbjct: 230 VGSIRYNYLLDVLERSPH--RPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHI 287
Query: 157 ---GDS------PLRENSRIAVLESGSLRI---HNVQKEDAGQYRCVAKNSLGTAY 200
G S P + + A + S + + NV EDAG+Y C+A NS+G +Y
Sbjct: 288 VINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSY 343
Score = 40.4 bits (93), Expect = 0.007
Identities = 47/206 (22%), Positives = 74/206 (35%), Gaps = 35/206 (16%)
Query: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174
L+ + P + + + + G L C G + W K S L R+ G
Sbjct: 30 LEPCLAPSLEQQEQELTVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWR-GR 85
Query: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYS-------KVVKLEVEVFARILRAPES------- 220
L I + EDAG+Y C+A+ S+ + + + + R P +
Sbjct: 86 LEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQ 145
Query: 221 --------------HNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVI 266
H V G+ V C A G P PTI W+++G A + ++ R
Sbjct: 146 APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQ 205
Query: 267 DSRLQLFITKP---GLYTCIATNKHG 289
L + P G YTC+ N G
Sbjct: 206 HWSLVMESVVPSDRGTYTCLVENAVG 231
Score = 34.7 bits (78), Expect = 0.39
Identities = 24/103 (23%), Positives = 43/103 (41%), Gaps = 13/103 (12%)
Query: 22 EKLPKAPVITTPLET-VDALVEEVATFMCAVESYPQPEISWTRNKIL------------I 68
E+ P P++ L A+V +C V S QP I W ++ ++ +
Sbjct: 243 ERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYV 302
Query: 69 KLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVES 111
++ T ++L + +V D G Y C A N +G + +S
Sbjct: 303 QVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 345
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 230 bits (587), Expect = 4e-60
Identities = 132/377 (35%), Positives = 199/377 (52%), Gaps = 19/377 (5%)
Query: 496 VIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELL----------- 544
+ +++ SF + VLL+ ++C + + +K S+A P++
Sbjct: 638 IAAAVLFSFIVSVLLSAFCIHCYHK---FAHKPPISSAEMTFRRPAQAFPVSYSSSGARR 694
Query: 545 --LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP 602
LD + +L +PK E+PR N+ + +GEG FG+V +A A L
Sbjct: 695 PSLDSMENQVSVDAFKILEDPKW---EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG 751
Query: 603 FTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGD 662
+T VAVKMLKE AS D E ++ + ++P+++KL G C+ P+ L+ EY YG
Sbjct: 752 YTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS 811
Query: 663 LNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFV 722
L FLR L + + P L+ + + A Q++ GM YL+E K V
Sbjct: 812 LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV 871
Query: 723 HRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTE 782
HRDLA RN LV E +KI+DFGLSR++Y D Y IP++WM ES+F + YTT+
Sbjct: 872 HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQ 931
Query: 783 SDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKL 842
SDVW++GV+LWEI + G PY G+ E + ++ G+ + P+NC E+Y LM CW +
Sbjct: 932 SDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE 991
Query: 843 PADRPSFTSIHRILERM 859
P RP F I + LE+M
Sbjct: 992 PDKRPVFADISKDLEKM 1008
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 230 bits (587), Expect = 4e-60
Identities = 132/377 (35%), Positives = 199/377 (52%), Gaps = 19/377 (5%)
Query: 496 VIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELL----------- 544
+ +++ SF + VLL+ ++C + + +K S+A P++
Sbjct: 638 IAAAVLFSFIVSVLLSAFCIHCYHK---FAHKPPISSAEMTFRRPAQAFPVSYSSSGARR 694
Query: 545 --LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP 602
LD + +L +PK E+PR N+ + +GEG FG+V +A A L
Sbjct: 695 PSLDSMENQVSVDAFKILEDPKW---EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG 751
Query: 603 FTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGD 662
+T VAVKMLKE AS D E ++ + ++P+++KL G C+ P+ L+ EY YG
Sbjct: 752 YTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS 811
Query: 663 LNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFV 722
L FLR L + + P L+ + + A Q++ GM YL+E K V
Sbjct: 812 LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV 871
Query: 723 HRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTE 782
HRDLA RN LV E +KI+DFGLSR++Y D Y IP++WM ES+F + YTT+
Sbjct: 872 HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQ 931
Query: 783 SDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKL 842
SDVW++GV+LWEI + G PY G+ E + ++ G+ + P+NC E+Y LM CW +
Sbjct: 932 SDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE 991
Query: 843 PADRPSFTSIHRILERM 859
P RP F I + LE+M
Sbjct: 992 PDKRPVFADISKDLEKM 1008
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 227 bits (578), Expect = 4e-59
Identities = 130/377 (34%), Positives = 201/377 (53%), Gaps = 30/377 (7%)
Query: 490 PTYSMTVIISIMSSFAIFVL-LTITTLYCCRRRK----QWKNKKRESAAVTLTTLPSELL 544
P +++I+S+++S + L L + + RRK Q + +S L+ L + +
Sbjct: 1029 PHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI 1088
Query: 545 LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT 604
+ +PN + ++ E PR NI +R +G GAFG V++ + G+ P +P
Sbjct: 1089 MTDYNPNYCFAGKTSSISDLK---EVPRKNITLIRGLGHGAFGEVYEGQVSGM-PNDPSP 1144
Query: 605 M-VAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDL 663
+ VAVK L E S + DF EA ++++F++ NIV+ +GV P +L E MA GDL
Sbjct: 1145 LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL 1204
Query: 664 NEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVH 723
FLR P P L+ + L +AR +A G YL E F+H
Sbjct: 1205 KSFLRETRPRP-----------------SQPSSLAMLDLLHVARDIACGCQYLEENHFIH 1247
Query: 724 RDLATRNCLV---GENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT 780
RD+A RNCL+ G V KI DFG++R+IY A YY+ +P++WMPPE+ +T
Sbjct: 1248 RDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFT 1307
Query: 781 TESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWS 840
+++D W++GV+LWEIFS G PY +++EV+ +V G + P+NCP +Y +M CW
Sbjct: 1308 SKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQ 1367
Query: 841 KLPADRPSFTSIHRILE 857
P DRP+F I +E
Sbjct: 1368 HQPEDRPNFAIILERIE 1384
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 226 bits (576), Expect = 7e-59
Identities = 130/319 (40%), Positives = 178/319 (55%), Gaps = 33/319 (10%)
Query: 557 MPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPF-----------TM 605
M LL + E+PR + + +GEG FG V G+ ++ +
Sbjct: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604
Query: 606 VAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNE 665
VAVKML+ +A+ + + DF +E +M+ +PNI+ LL VC P+C++ EYM GDLN+
Sbjct: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664
Query: 666 FLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRD 725
FL S H + S SD+ +S +A Q+A+GM YLS FVHRD
Sbjct: 665 FL---SRHEPPNSSSSDVRT-----------VSYTNLKFMATQIASGMKYLSSLNFVHRD 710
Query: 726 LATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDV 785
LATRNCLVG+N +KIADFG+SRN+YS DYY+ +PIRWM ESI ++TT SDV
Sbjct: 711 LATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDV 770
Query: 786 WAYGVVLWEIFSY-GLQPYYGMAHEEVI----YYVRD---GNILSCPENCPVELYNLMRL 837
WA+GV LWE F++ QPY ++ E+VI + RD L P CP +Y LM
Sbjct: 771 WAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLS 830
Query: 838 CWSKLPADRPSFTSIHRIL 856
CW + +RPSF IH +L
Sbjct: 831 CWRRDTKNRPSFQEIHLLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 226 bits (576), Expect = 7e-59
Identities = 130/319 (40%), Positives = 178/319 (55%), Gaps = 33/319 (10%)
Query: 557 MPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPF-----------TM 605
M LL + E+PR + + +GEG FG V G+ ++ +
Sbjct: 545 MDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVL 604
Query: 606 VAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNE 665
VAVKML+ +A+ + + DF +E +M+ +PNI+ LL VC P+C++ EYM GDLN+
Sbjct: 605 VAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQ 664
Query: 666 FLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRD 725
FL S H + S SD+ +S +A Q+A+GM YLS FVHRD
Sbjct: 665 FL---SRHEPPNSSSSDVRT-----------VSYTNLKFMATQIASGMKYLSSLNFVHRD 710
Query: 726 LATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDV 785
LATRNCLVG+N +KIADFG+SRN+YS DYY+ +PIRWM ESI ++TT SDV
Sbjct: 711 LATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDV 770
Query: 786 WAYGVVLWEIFSY-GLQPYYGMAHEEVI----YYVRD---GNILSCPENCPVELYNLMRL 837
WA+GV LWE F++ QPY ++ E+VI + RD L P CP +Y LM
Sbjct: 771 WAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLS 830
Query: 838 CWSKLPADRPSFTSIHRIL 856
CW + +RPSF IH +L
Sbjct: 831 CWRRDTKNRPSFQEIHLLL 849
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 226 bits (575), Expect = 9e-59
Identities = 127/314 (40%), Positives = 178/314 (56%), Gaps = 36/314 (11%)
Query: 568 LEYPRNNIEYVRDIGEGAFGRVF--QARAPGLLPYEPFTM---------VAVKMLKEEAS 616
+++PR+ + + +GEG FG V + +P L F + VAVK+L+ +A+
Sbjct: 566 VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 625
Query: 617 ADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVC 676
+ + DF +E +M+ +PNI++LLGVC P+C++ +YM GDLN+FL
Sbjct: 626 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL--------- 676
Query: 677 SLSHSDLSMRAQVSSPGP------PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRN 730
S L +A +PG P +S L +A Q+A+GM YL+ FVHRDLATRN
Sbjct: 677 --SAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 734
Query: 731 CLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGV 790
CLVGEN +KIADFG+SRN+Y+ DYY+ +PIRWM E I ++TT SDVWA+GV
Sbjct: 735 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 794
Query: 791 VLWEIFSY-GLQPYYGMAHEEVI----YYVRDGN---ILSCPENCPVELYNLMRLCWSKL 842
LWE+ QP+ + E+VI + RD LS P CP LY LM CWS+
Sbjct: 795 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 854
Query: 843 PADRPSFTSIHRIL 856
RP F+ +HR L
Sbjct: 855 SEQRPPFSQLHRFL 868
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 226 bits (575), Expect = 9e-59
Identities = 127/314 (40%), Positives = 178/314 (56%), Gaps = 36/314 (11%)
Query: 568 LEYPRNNIEYVRDIGEGAFGRVF--QARAPGLLPYEPFTM---------VAVKMLKEEAS 616
+++PR+ + + +GEG FG V + +P L F + VAVK+L+ +A+
Sbjct: 603 VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 662
Query: 617 ADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVC 676
+ + DF +E +M+ +PNI++LLGVC P+C++ +YM GDLN+FL
Sbjct: 663 KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL--------- 713
Query: 677 SLSHSDLSMRAQVSSPGP------PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRN 730
S L +A +PG P +S L +A Q+A+GM YL+ FVHRDLATRN
Sbjct: 714 --SAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 771
Query: 731 CLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGV 790
CLVGEN +KIADFG+SRN+Y+ DYY+ +PIRWM E I ++TT SDVWA+GV
Sbjct: 772 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGV 831
Query: 791 VLWEIFSY-GLQPYYGMAHEEVI----YYVRDGN---ILSCPENCPVELYNLMRLCWSKL 842
LWE+ QP+ + E+VI + RD LS P CP LY LM CWS+
Sbjct: 832 TLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 891
Query: 843 PADRPSFTSIHRIL 856
RP F+ +HR L
Sbjct: 892 SEQRPPFSQLHRFL 905
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 219 bits (559), Expect = 7e-57
Identities = 125/312 (40%), Positives = 179/312 (57%), Gaps = 19/312 (6%)
Query: 558 PLLLNPKLLSL------EYPRNNIEYVRDIGEGAFGRVFQARAPGL---LPYEPFTMVAV 608
P L N L L E R + + +GEG FG+V A A G+ +P T VAV
Sbjct: 451 PTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVT-VAV 509
Query: 609 KMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL 667
KMLK++A+ +D E +M + NI+ LLG C G P+ +L EY A G+L EFL
Sbjct: 510 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 569
Query: 668 RSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLA 727
R+ P L P L+ + + A QVA GM YL+ +K +HRDLA
Sbjct: 570 RARRP--------PGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 621
Query: 728 TRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWA 787
RN LV E+ V+KIADFGL+R++++ DYYK N +P++WM PE++F YT +SDVW+
Sbjct: 622 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 681
Query: 788 YGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRP 847
+GV+LWEIF+ G PY G+ EE+ +++G+ + P NC +LY +MR CW P+ RP
Sbjct: 682 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 741
Query: 848 SFTSIHRILERM 859
+F + L+R+
Sbjct: 742 TFKQLVEDLDRV 753
Score = 59.3 bits (142), Expect = 1e-08
Identities = 55/171 (32%), Positives = 71/171 (41%), Gaps = 30/171 (17%)
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRIAVL----ESGSLRIHNVQKEDAGQYRCVAKNSLG 197
C GNP PS+SW+K R RI + + SL + +V D G Y CV +N G
Sbjct: 176 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 198 T---AYSKVVKLEVEVFARILRA--PESHNVTFGSFVTLHCTATGIPVPTITWIE----N 248
+ Y+ V LE IL+A P + GS V HC P I W++ N
Sbjct: 236 SIRQTYTLDV-LERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVN 294
Query: 249 GNAVSSGS----------IQESVKDRVIDSRLQLFITKP---GLYTCIATN 286
G+ V I ESV+ D RL+L G Y C ATN
Sbjct: 295 GSKVGPDGTPYVTVLKSWISESVE---ADVRLRLANVSERDGGEYLCRATN 342
Score = 47.8 bits (112), Expect = 4e-05
Identities = 47/179 (26%), Positives = 68/179 (37%), Gaps = 31/179 (17%)
Query: 47 FMCAVESYPQPEISWTRNKILIKLFDTRYSI-----RENGQLLTILSVEDSDDGIYCCTA 101
F C P P ISW +N + F + I R L + SV SD G Y C
Sbjct: 174 FRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVV 230
Query: 102 NNGVGGAVESCGALQVKMKPKITRP------PINVKIIEGLKAVLPCTTMGNPKPSVSWI 155
N G ++ ++ P RP P N + G C + +P + W+
Sbjct: 231 ENKFGSIRQTYTLDVLERSPH--RPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL 288
Query: 156 K----GDSPLRENSR--IAVLESG---------SLRIHNVQKEDAGQYRCVAKNSLGTA 199
K S + + + VL+S LR+ NV + D G+Y C A N +G A
Sbjct: 289 KHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVA 347
Score = 40.4 bits (93), Expect = 0.007
Identities = 41/171 (23%), Positives = 62/171 (36%), Gaps = 28/171 (16%)
Query: 146 GNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVK 205
G P W+K + L + R+ V L++ N ED+G Y C + + V+
Sbjct: 66 GGPMGPTVWVKDGTGLVPSERVLVGPQ-RLQVLNASHEDSGAYSCRQRLTQRVLCHFSVR 124
Query: 206 LE-------------------VEVFARILRAPESHN-----VTFGSFVTLHCTATGIPVP 241
+ V+ A PE + V + V C A G P P
Sbjct: 125 VTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTP 184
Query: 242 TITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHG 289
+I+W++NG +K R L + P G YTC+ NK G
Sbjct: 185 SISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 235
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 219 bits (559), Expect = 7e-57
Identities = 125/312 (40%), Positives = 179/312 (57%), Gaps = 19/312 (6%)
Query: 558 PLLLNPKLLSL------EYPRNNIEYVRDIGEGAFGRVFQARAPGL---LPYEPFTMVAV 608
P L N L L E R + + +GEG FG+V A A G+ +P T VAV
Sbjct: 337 PTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVT-VAV 395
Query: 609 KMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL 667
KMLK++A+ +D E +M + NI+ LLG C G P+ +L EY A G+L EFL
Sbjct: 396 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 455
Query: 668 RSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLA 727
R+ P L P L+ + + A QVA GM YL+ +K +HRDLA
Sbjct: 456 RARRP--------PGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 507
Query: 728 TRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWA 787
RN LV E+ V+KIADFGL+R++++ DYYK N +P++WM PE++F YT +SDVW+
Sbjct: 508 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 567
Query: 788 YGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRP 847
+GV+LWEIF+ G PY G+ EE+ +++G+ + P NC +LY +MR CW P+ RP
Sbjct: 568 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 627
Query: 848 SFTSIHRILERM 859
+F + L+R+
Sbjct: 628 TFKQLVEDLDRV 639
Score = 56.2 bits (134), Expect = 1e-07
Identities = 38/116 (32%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRIAVL----ESGSLRIHNVQKEDAGQYRCVAKNSLG 197
C GNP PS+SW+K R RI + + SL + +V D G Y CV +N G
Sbjct: 176 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 198 T---AYSKVVKLEVEVFARILRA--PESHNVTFGSFVTLHCTATGIPVPTITWIEN 248
+ Y+ V LE IL+A P + GS V HC P I W+++
Sbjct: 236 SIRQTYTLDV-LERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKH 290
Score = 40.4 bits (93), Expect = 0.007
Identities = 41/171 (23%), Positives = 62/171 (36%), Gaps = 28/171 (16%)
Query: 146 GNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVK 205
G P W+K + L + R+ V L++ N ED+G Y C + + V+
Sbjct: 66 GGPMGPTVWVKDGTGLVPSERVLVGPQ-RLQVLNASHEDSGAYSCRQRLTQRVLCHFSVR 124
Query: 206 LE-------------------VEVFARILRAPESHN-----VTFGSFVTLHCTATGIPVP 241
+ V+ A PE + V + V C A G P P
Sbjct: 125 VTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTP 184
Query: 242 TITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHG 289
+I+W++NG +K R L + P G YTC+ NK G
Sbjct: 185 SISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 235
Score = 36.6 bits (83), Expect = 0.10
Identities = 31/121 (25%), Positives = 44/121 (36%), Gaps = 16/121 (13%)
Query: 47 FMCAVESYPQPEISWTRNKILIKLFDTRYSI-----RENGQLLTILSVEDSDDGIYCCTA 101
F C P P ISW +N + F + I R L + SV SD G Y C
Sbjct: 174 FRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVV 230
Query: 102 NNGVGGAVESCGALQVKMKPKITRP------PINVKIIEGLKAVLPCTTMGNPKPSVSWI 155
N G ++ ++ P RP P N + G C + +P + W+
Sbjct: 231 ENKFGSIRQTYTLDVLERSPH--RPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL 288
Query: 156 K 156
K
Sbjct: 289 K 289
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 219 bits (559), Expect = 7e-57
Identities = 125/312 (40%), Positives = 179/312 (57%), Gaps = 19/312 (6%)
Query: 558 PLLLNPKLLSL------EYPRNNIEYVRDIGEGAFGRVFQARAPGL---LPYEPFTMVAV 608
P L N L L E R + + +GEG FG+V A A G+ +P T VAV
Sbjct: 449 PTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVT-VAV 507
Query: 609 KMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL 667
KMLK++A+ +D E +M + NI+ LLG C G P+ +L EY A G+L EFL
Sbjct: 508 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
Query: 668 RSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLA 727
R+ P L P L+ + + A QVA GM YL+ +K +HRDLA
Sbjct: 568 RARRP--------PGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 619
Query: 728 TRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWA 787
RN LV E+ V+KIADFGL+R++++ DYYK N +P++WM PE++F YT +SDVW+
Sbjct: 620 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 679
Query: 788 YGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRP 847
+GV+LWEIF+ G PY G+ EE+ +++G+ + P NC +LY +MR CW P+ RP
Sbjct: 680 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 739
Query: 848 SFTSIHRILERM 859
+F + L+R+
Sbjct: 740 TFKQLVEDLDRV 751
Score = 62.4 bits (150), Expect = 2e-09
Identities = 57/198 (28%), Positives = 80/198 (40%), Gaps = 27/198 (13%)
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRIAVL----ESGSLRIHNVQKEDAGQYRCVAKNSLG 197
C GNP PS+SW+K R RI + + SL + +V D G Y CV +N G
Sbjct: 176 CPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 198 T---AYSKVVKLEVEVFARILRA--PESHNVTFGSFVTLHCTATGIPVPTITWIE----N 248
+ Y+ V LE IL+A P + GS V HC P I W++ N
Sbjct: 236 SIRQTYTLDV-LERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVN 294
Query: 249 GNAVSSG-----SIQESVKDRVIDSRLQLF------ITKPGLYTCIATNKHGEKFSTAKA 297
G+ V ++ ++ D L++ G YTC+A N G FS A
Sbjct: 295 GSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG--FSHHSA 352
Query: 298 AATISIAEWSKPQKDNKG 315
+ AE + D G
Sbjct: 353 WLVVLPAEEELVEADEAG 370
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/207 (25%), Positives = 82/207 (39%), Gaps = 32/207 (15%)
Query: 47 FMCAVESYPQPEISWTRNKILIKLFDTRYSI-----RENGQLLTILSVEDSDDGIYCCTA 101
F C P P ISW +N + F + I R L + SV SD G Y C
Sbjct: 174 FRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVV 230
Query: 102 NNGVGGAVESCGALQVKMKPKITRP------PINVKIIEGLKAVLPCTTMGNPKPSVSWI 155
N G ++ ++ P RP P N + G C + +P + W+
Sbjct: 231 ENKFGSIRQTYTLDVLERSPH--RPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL 288
Query: 156 K----GDSPLRENSR--IAVLESGS----------LRIHNVQKEDAGQYRCVAKNSLGTA 199
K S + + + VL++ L +HNV EDAG+Y C+A NS+G +
Sbjct: 289 KHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFS 348
Query: 200 YSKVVKLEVEVFARILRAPESHNVTFG 226
+ + + ++ A E+ +V G
Sbjct: 349 HHSAWLVVLPAEEELVEADEAGSVYAG 375
Score = 40.4 bits (93), Expect = 0.007
Identities = 41/171 (23%), Positives = 62/171 (36%), Gaps = 28/171 (16%)
Query: 146 GNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVK 205
G P W+K + L + R+ V L++ N ED+G Y C + + V+
Sbjct: 66 GGPMGPTVWVKDGTGLVPSERVLVGPQ-RLQVLNASHEDSGAYSCRQRLTQRVLCHFSVR 124
Query: 206 LE-------------------VEVFARILRAPESHN-----VTFGSFVTLHCTATGIPVP 241
+ V+ A PE + V + V C A G P P
Sbjct: 125 VTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTP 184
Query: 242 TITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHG 289
+I+W++NG +K R L + P G YTC+ NK G
Sbjct: 185 SISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFG 235
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 219 bits (558), Expect = 9e-57
Identities = 127/320 (39%), Positives = 178/320 (55%), Gaps = 42/320 (13%)
Query: 568 LEYPRNNIEYVRDIGEGAFGRVF--QARAPGLLPYEPFTM---------VAVKMLKEEAS 616
+++PR+ + + +GEG FG V + +P L F + VAVK+L+ +A+
Sbjct: 603 VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 662
Query: 617 ADM------QADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSM 670
+ + DF +E +M+ +PNI++LLGVC P+C++ +YM GDLN+FL
Sbjct: 663 KNASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFL--- 719
Query: 671 SPHTVCSLSHSDLSMRAQVSSPGP------PPLSCAEQLCIARQVAAGMAYLSERKFVHR 724
S L +A +PG P +S L +A Q+A+GM YL+ FVHR
Sbjct: 720 --------SAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHR 771
Query: 725 DLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESD 784
DLATRNCLVGEN +KIADFG+SRN+Y+ DYY+ +PIRWM E I ++TT SD
Sbjct: 772 DLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASD 831
Query: 785 VWAYGVVLWEIFSY-GLQPYYGMAHEEVI----YYVRDGN---ILSCPENCPVELYNLMR 836
VWA+GV LWE+ QP+ + E+VI + RD LS P CP LY LM
Sbjct: 832 VWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELML 891
Query: 837 LCWSKLPADRPSFTSIHRIL 856
CWS+ RP F+ +HR L
Sbjct: 892 RCWSRESEQRPPFSQLHRFL 911
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 218 bits (556), Expect = 1e-56
Identities = 121/294 (41%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--FTMVAVKMLKEEASADMQADFQRE 626
E PR+ + + +GEG FG+V A A GL +P T VAVKMLK +A+ +D E
Sbjct: 381 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 440
Query: 627 AALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSM 685
+M + NI+ LLG C P+ ++ EY + G+L E+L++ P + + +
Sbjct: 441 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 500
Query: 686 RAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 745
Q+SS +SCA Q VA GM YL+ +K +HRDLA RN LV E+ V+KIADFG
Sbjct: 501 EEQLSSKDL--VSCAYQ------VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 552
Query: 746 LSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 805
L+R+I+ DYYK N +P++WM PE++F YT +SDVW++GV+LWEIF+ G PY G
Sbjct: 553 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 612
Query: 806 MAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
+ EE+ +++G+ + P NC ELY +MR CW +P+ RP+F + L+R+
Sbjct: 613 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 666
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/209 (26%), Positives = 82/209 (39%), Gaps = 32/209 (15%)
Query: 21 TEKLPKAPVITTPLETVDAL----VEEVATFMCAVESYPQPEISWTRNKILIKLFDTR-- 74
T+ P AP T+P + L + F C P P + W +N K D R
Sbjct: 55 TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIG 113
Query: 75 -YSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRP------P 127
Y +R + + SV SD G Y C N G + V+ P RP P
Sbjct: 114 GYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH--RPILQAGLP 171
Query: 128 INVKIIEGLKAVLPCTTMGNPKPSVSWIK-----GDSPLREN-SRIAVLESGS------- 174
N + G C +P+P + W+K G +N + +L++
Sbjct: 172 ANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKE 231
Query: 175 ---LRIHNVQKEDAGQYRCVAKNSLGTAY 200
L + NV EDAG+Y C+A NS+G ++
Sbjct: 232 MEVLHLRNVSFEDAGEYTCLAGNSIGLSH 260
Score = 50.1 bits (118), Expect = 9e-06
Identities = 40/171 (23%), Positives = 70/171 (40%), Gaps = 23/171 (13%)
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRIAVLE----SGSLRIHNVQKEDAGQYRCVAKNSLG 197
C + G P P++ W+K + + RI + + S+ + +V D G Y C+ +N G
Sbjct: 87 CPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG 146
Query: 198 TAYS--KVVKLEVEVFARILRA--PESHNVTFGSFVTLHCTATGIPVPTITWIE----NG 249
+ ++ +E IL+A P + V GS V C P P I W++ NG
Sbjct: 147 SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 206
Query: 250 NAV-----------SSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHG 289
+ + + + + K+ + + G YTC+A N G
Sbjct: 207 SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 257
Score = 36.6 bits (83), Expect = 0.10
Identities = 20/75 (26%), Positives = 36/75 (48%), Gaps = 9/75 (12%)
Query: 221 HNVTFGSFVTLHCTATGIPVPTITWIENG------NAVSSGSIQESVKDRVIDSRLQLFI 274
H V V C ++G P PT+ W++NG + + ++ + ++DS +
Sbjct: 75 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS---VVP 131
Query: 275 TKPGLYTCIATNKHG 289
+ G YTCI N++G
Sbjct: 132 SDKGNYTCIVENEYG 146
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 218 bits (556), Expect = 1e-56
Identities = 121/294 (41%), Positives = 178/294 (60%), Gaps = 11/294 (3%)
Query: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP--FTMVAVKMLKEEASADMQADFQRE 626
E PR+ + + +GEG FG+V A A GL +P T VAVKMLK +A+ +D E
Sbjct: 383 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 442
Query: 627 AALMAEFD-NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSM 685
+M + NI+ LLG C P+ ++ EY + G+L E+L++ P + + +
Sbjct: 443 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 502
Query: 686 RAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFG 745
Q+SS +SCA Q VA GM YL+ +K +HRDLA RN LV E+ V+KIADFG
Sbjct: 503 EEQLSSKDL--VSCAYQ------VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 554
Query: 746 LSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG 805
L+R+I+ DYYK N +P++WM PE++F YT +SDVW++GV+LWEIF+ G PY G
Sbjct: 555 LARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG 614
Query: 806 MAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
+ EE+ +++G+ + P NC ELY +MR CW +P+ RP+F + L+R+
Sbjct: 615 VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668
Score = 57.8 bits (138), Expect = 4e-08
Identities = 54/207 (26%), Positives = 82/207 (39%), Gaps = 32/207 (15%)
Query: 23 KLPKAPVITTPLETVDAL----VEEVATFMCAVESYPQPEISWTRNKILIKLFDTR---Y 75
++P AP T+P + L + F C P P + W +N K D R Y
Sbjct: 59 RMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKP-DHRIGGY 117
Query: 76 SIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRP------PIN 129
+R + + SV SD G Y C N G + V+ P RP P N
Sbjct: 118 KVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH--RPILQAGLPAN 175
Query: 130 VKIIEGLKAVLPCTTMGNPKPSVSWIK-----GDSPLREN-SRIAVLESGS--------- 174
+ G C +P+P + W+K G +N + +L++
Sbjct: 176 KTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEME 235
Query: 175 -LRIHNVQKEDAGQYRCVAKNSLGTAY 200
L + NV EDAG+Y C+A NS+G ++
Sbjct: 236 VLHLRNVSFEDAGEYTCLAGNSIGLSH 262
Score = 50.1 bits (118), Expect = 9e-06
Identities = 40/171 (23%), Positives = 70/171 (40%), Gaps = 23/171 (13%)
Query: 142 CTTMGNPKPSVSWIKGDSPLRENSRIAVLE----SGSLRIHNVQKEDAGQYRCVAKNSLG 197
C + G P P++ W+K + + RI + + S+ + +V D G Y C+ +N G
Sbjct: 89 CPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG 148
Query: 198 TAYS--KVVKLEVEVFARILRA--PESHNVTFGSFVTLHCTATGIPVPTITWIE----NG 249
+ ++ +E IL+A P + V GS V C P P I W++ NG
Sbjct: 149 SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 208
Query: 250 NAV-----------SSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHG 289
+ + + + + K+ + + G YTC+A N G
Sbjct: 209 SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 259
Score = 36.6 bits (83), Expect = 0.10
Identities = 20/75 (26%), Positives = 36/75 (48%), Gaps = 9/75 (12%)
Query: 221 HNVTFGSFVTLHCTATGIPVPTITWIENG------NAVSSGSIQESVKDRVIDSRLQLFI 274
H V V C ++G P PT+ W++NG + + ++ + ++DS +
Sbjct: 77 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS---VVP 133
Query: 275 TKPGLYTCIATNKHG 289
+ G YTCI N++G
Sbjct: 134 SDKGNYTCIVENEYG 148
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,660,258
Number of Sequences: 37866
Number of extensions: 1679113
Number of successful extensions: 12038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 727
Number of HSP's successfully gapped in prelim test: 374
Number of HSP's that attempted gapping in prelim test: 4754
Number of HSP's gapped (non-prelim): 3544
length of query: 869
length of database: 18,247,518
effective HSP length: 111
effective length of query: 758
effective length of database: 14,044,392
effective search space: 10645649136
effective search space used: 10645649136
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.