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Search of human proteins with 5031689
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031689 protein kinase D3 [Homo sapiens]
(890 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031689 protein kinase D3 [Homo sapiens] 1821 0.0
gi|115529463 protein kinase D1 [Homo sapiens] 1232 0.0
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 1117 0.0
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 1117 0.0
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 1117 0.0
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 961 0.0
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 191 2e-48
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 191 2e-48
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 179 1e-44
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 172 1e-42
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 172 1e-42
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 169 1e-41
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 166 9e-41
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 166 9e-41
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 166 1e-40
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 165 2e-40
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 159 1e-38
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 158 2e-38
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 157 5e-38
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 157 5e-38
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 157 5e-38
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 157 5e-38
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 157 5e-38
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 157 5e-38
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 153 6e-37
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 152 1e-36
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 152 1e-36
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 152 1e-36
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 152 1e-36
gi|27901803 protein serine kinase H1 [Homo sapiens] 152 2e-36
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 1821 bits (4718), Expect = 0.0
Identities = 890/890 (100%), Positives = 890/890 (100%)
Query: 1 MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV 60
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV
Sbjct: 1 MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV 60
Query: 61 SFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSEN 120
SFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSEN
Sbjct: 61 SFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSEN 120
Query: 121 ILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVR 180
ILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVR
Sbjct: 121 ILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVR 180
Query: 181 QGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEES 240
QGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEES
Sbjct: 181 QGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEES 240
Query: 241 HVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGM 300
HVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGM
Sbjct: 241 HVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGM 300
Query: 301 QCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDT 360
QCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDT
Sbjct: 301 QCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDT 360
Query: 361 EEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKE 420
EEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKE
Sbjct: 361 EEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKE 420
Query: 421 GWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQG 480
GWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQG
Sbjct: 421 GWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQG 480
Query: 481 SNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASV 540
SNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASV
Sbjct: 481 SNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASV 540
Query: 541 CTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGR 600
CTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGR
Sbjct: 541 CTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGR 600
Query: 601 DVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDML 660
DVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDML
Sbjct: 601 DVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDML 660
Query: 661 EMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCD 720
EMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCD
Sbjct: 661 EMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCD 720
Query: 721 FGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE 780
FGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE
Sbjct: 721 FGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE 780
Query: 781 DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLD 840
DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLD
Sbjct: 781 DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLD 840
Query: 841 LREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP 890
LREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
Sbjct: 841 LREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP 890
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 1232 bits (3188), Expect = 0.0
Identities = 626/891 (70%), Positives = 715/891 (80%), Gaps = 33/891 (3%)
Query: 22 VLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTI---EAQ 78
+LP A+ ++ L +G AP L V +SF LQIGL+RE V + +
Sbjct: 13 LLPVAAAAAAAAAALVP--GSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSG 70
Query: 79 ELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVE 138
+ SL+ V+++ CSIV QKFPECGF+GMYDKILLFRHD SENILQL+ +A +I EGDL+E
Sbjct: 71 DYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIE 130
Query: 139 VVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAF 198
VVLSA AT EDFQIRPH L+VHSY+AP FCD+CGEMLWGLVRQGLKCEGCGLNYHKRCAF
Sbjct: 131 VVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAF 190
Query: 199 KIPNNCSGVRKRRLSNVSLPGPG--------LSVPRPLQPEYVALPSEESHVHQEPSKRI 250
KIPNNCSGVR+RRLSNVSL G LS P +P PSE S + +E
Sbjct: 191 KIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSE-SFIGREKRSNS 249
Query: 251 PSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCH 310
S+ GRPI ++K++M +VKVPHTF +HSYTRPT+CQYCK+LLKGLFRQG+QCKDC+FNCH
Sbjct: 250 QSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCH 309
Query: 311 KRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGL-DDTEEPSPPEDK 369
KRCA KVP +CLGEVT NG+ S G ++D+ M+ ++D +S+ + GL DD EE + +
Sbjct: 310 KRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAE 369
Query: 370 MFFLDPSDLDVERD------EEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWM 423
M + + E E+A +TISPSTSNNIPLMRVVQS+KHTKRKSST++KEGWM
Sbjct: 370 MAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWM 429
Query: 424 VHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNP 483
VHYTS+D LRKRHYWRLDSKC+TLFQN++GS+YYKEIPLSEIL + + I G+NP
Sbjct: 430 VHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANP 489
Query: 484 HCFEIITDTMVYFVGEN----NGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQAS 539
HCFEI T +VY+VGEN + S +N VL + GVG DVA+ WE AI+ ALMPV P+ S
Sbjct: 490 HCFEITTANVVYYVGENVVNPSSPSPNNSVLTS-GVGADVARMWEIAIQHALMPVIPKGS 548
Query: 540 VCTSPGQGKD-HKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKT 598
S G G + H+D+S SISVSNCQIQENVDISTVYQIF DEVLGSGQFGIVYGGKHRKT
Sbjct: 549 ---SVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKT 605
Query: 599 GRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGD 658
GRDVAIK+IDK+RFPTKQESQLRNEVAILQNLHHPG+VNLECMFETPERVFVVMEKLHGD
Sbjct: 606 GRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGD 665
Query: 659 MLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKL 718
MLEMILSSEK RLPE ITKF++TQILVALR+LHFKNIVHCDLKPENVLLASA+PFPQVKL
Sbjct: 666 MLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKL 725
Query: 719 CDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNE 778
CDFGFARIIGEKSFRRSVVGTPAYLAPEVLR+KGYNRSLDMWSVGVIIYVSLSGTFPFNE
Sbjct: 726 CDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNE 785
Query: 779 DEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTW 838
DEDI+DQIQNAAFMYPPNPW+EIS EAIDLINNLLQVKMRKRYSVDK+LSHPWLQDYQTW
Sbjct: 786 DEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTW 845
Query: 839 LDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEED 889
LDLRE E +IGERYITHESDD RWE +A L YP H I NP D
Sbjct: 846 LDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLI---NPSASHSD 893
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1117 bits (2888), Expect = 0.0
Identities = 570/861 (66%), Positives = 661/861 (76%), Gaps = 31/861 (3%)
Query: 20 PAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQE 79
PA LP + SP L + P L VSF +QIGLTRE V + A
Sbjct: 8 PAGLPGSPGPGSPPPPGGLELQS---PPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS 64
Query: 80 LSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV 139
L+ VK L CSIV QKFPECGF+G+YDKILLF+HD S N+LQL+ S+ +I EGDLVEV
Sbjct: 65 -ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEV 123
Query: 140 VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFK 199
VLSA AT EDFQIRPH L VHSY+AP FCD+CGEML+GLVRQGLKC+GCGLNYHKRCAF
Sbjct: 124 VLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS 183
Query: 200 IPNNCSGVRKRRLSNVSLPGP-----GLSVPRPLQPEYVALPSEESHVHQEPSKR----I 250
IPNNCSG RKRRLS+ SL G S P E ++ + E + PS
Sbjct: 184 IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSA 243
Query: 251 PSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCH 310
S++GRPI ++KM++ +VKVPHTF +HSYTRPT+CQ CK+LLKGLFRQG+QCKDCKFNCH
Sbjct: 244 SSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCH 303
Query: 311 KRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKM 370
KRCA++VP DCLGE NG D+PM+ + +D S +D++E+
Sbjct: 304 KRCATRVPNDCLGEALING---------DVPMEEATDFSEADKSALMDESEDSGVIPGSH 354
Query: 371 FFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRD 430
+ L +EE + S+ IPLMRVVQS++HT RKSST ++EGW+VHY+++D
Sbjct: 355 ---SENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKD 411
Query: 431 NLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIIT 490
LRKRHYWRLD KC+TLFQN + ++YYKEIPLSEIL + S ++F+ + G+NPHCFEI+T
Sbjct: 412 TLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVT 471
Query: 491 DTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDH 550
YFVGE G + P +G G + A+ WE AIRQALMPV Q + ++PG H
Sbjct: 472 ANATYFVGEMPGGTPGGP----SGQGAEAARGWETAIRQALMPVILQDAP-SAPGHAP-H 525
Query: 551 KDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKM 610
+ S SISVSN QIQENVDI+TVYQIF DEVLGSGQFG+VYGGKHRKTGRDVA+KVIDK+
Sbjct: 526 RQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKL 585
Query: 611 RFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSR 670
RFPTKQESQLRNEVAILQ+L HPGIVNLECMFETPE+VFVVMEKLHGDMLEMILSSEK R
Sbjct: 586 RFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGR 645
Query: 671 LPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK 730
LPER+TKF++TQILVALR+LHFKNIVHCDLKPENVLLASA+PFPQVKLCDFGFARIIGEK
Sbjct: 646 LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK 705
Query: 731 SFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAA 790
SFRRSVVGTPAYLAPEVL ++GYNRSLDMWSVGVI+YVSLSGTFPFNEDEDINDQIQNAA
Sbjct: 706 SFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAA 765
Query: 791 FMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGE 850
FMYP +PW IS AIDLINNLLQVKMRKRYSVDKSLSHPWLQ+YQTWLDLRE E ++GE
Sbjct: 766 FMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGE 825
Query: 851 RYITHESDDARWEIHAYTHNL 871
RYITHESDDARWE A H L
Sbjct: 826 RYITHESDDARWEQFAAEHPL 846
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1117 bits (2888), Expect = 0.0
Identities = 570/861 (66%), Positives = 661/861 (76%), Gaps = 31/861 (3%)
Query: 20 PAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQE 79
PA LP + SP L + P L VSF +QIGLTRE V + A
Sbjct: 8 PAGLPGSPGPGSPPPPGGLELQS---PPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS 64
Query: 80 LSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV 139
L+ VK L CSIV QKFPECGF+G+YDKILLF+HD S N+LQL+ S+ +I EGDLVEV
Sbjct: 65 -ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEV 123
Query: 140 VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFK 199
VLSA AT EDFQIRPH L VHSY+AP FCD+CGEML+GLVRQGLKC+GCGLNYHKRCAF
Sbjct: 124 VLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS 183
Query: 200 IPNNCSGVRKRRLSNVSLPGP-----GLSVPRPLQPEYVALPSEESHVHQEPSKR----I 250
IPNNCSG RKRRLS+ SL G S P E ++ + E + PS
Sbjct: 184 IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSA 243
Query: 251 PSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCH 310
S++GRPI ++KM++ +VKVPHTF +HSYTRPT+CQ CK+LLKGLFRQG+QCKDCKFNCH
Sbjct: 244 SSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCH 303
Query: 311 KRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKM 370
KRCA++VP DCLGE NG D+PM+ + +D S +D++E+
Sbjct: 304 KRCATRVPNDCLGEALING---------DVPMEEATDFSEADKSALMDESEDSGVIPGSH 354
Query: 371 FFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRD 430
+ L +EE + S+ IPLMRVVQS++HT RKSST ++EGW+VHY+++D
Sbjct: 355 ---SENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKD 411
Query: 431 NLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIIT 490
LRKRHYWRLD KC+TLFQN + ++YYKEIPLSEIL + S ++F+ + G+NPHCFEI+T
Sbjct: 412 TLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVT 471
Query: 491 DTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDH 550
YFVGE G + P +G G + A+ WE AIRQALMPV Q + ++PG H
Sbjct: 472 ANATYFVGEMPGGTPGGP----SGQGAEAARGWETAIRQALMPVILQDAP-SAPGHAP-H 525
Query: 551 KDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKM 610
+ S SISVSN QIQENVDI+TVYQIF DEVLGSGQFG+VYGGKHRKTGRDVA+KVIDK+
Sbjct: 526 RQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKL 585
Query: 611 RFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSR 670
RFPTKQESQLRNEVAILQ+L HPGIVNLECMFETPE+VFVVMEKLHGDMLEMILSSEK R
Sbjct: 586 RFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGR 645
Query: 671 LPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK 730
LPER+TKF++TQILVALR+LHFKNIVHCDLKPENVLLASA+PFPQVKLCDFGFARIIGEK
Sbjct: 646 LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK 705
Query: 731 SFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAA 790
SFRRSVVGTPAYLAPEVL ++GYNRSLDMWSVGVI+YVSLSGTFPFNEDEDINDQIQNAA
Sbjct: 706 SFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAA 765
Query: 791 FMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGE 850
FMYP +PW IS AIDLINNLLQVKMRKRYSVDKSLSHPWLQ+YQTWLDLRE E ++GE
Sbjct: 766 FMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGE 825
Query: 851 RYITHESDDARWEIHAYTHNL 871
RYITHESDDARWE A H L
Sbjct: 826 RYITHESDDARWEQFAAEHPL 846
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1117 bits (2888), Expect = 0.0
Identities = 570/861 (66%), Positives = 661/861 (76%), Gaps = 31/861 (3%)
Query: 20 PAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQE 79
PA LP + SP L + P L VSF +QIGLTRE V + A
Sbjct: 8 PAGLPGSPGPGSPPPPGGLELQS---PPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS 64
Query: 80 LSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV 139
L+ VK L CSIV QKFPECGF+G+YDKILLF+HD S N+LQL+ S+ +I EGDLVEV
Sbjct: 65 -ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEV 123
Query: 140 VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFK 199
VLSA AT EDFQIRPH L VHSY+AP FCD+CGEML+GLVRQGLKC+GCGLNYHKRCAF
Sbjct: 124 VLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS 183
Query: 200 IPNNCSGVRKRRLSNVSLPGP-----GLSVPRPLQPEYVALPSEESHVHQEPSKR----I 250
IPNNCSG RKRRLS+ SL G S P E ++ + E + PS
Sbjct: 184 IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSA 243
Query: 251 PSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCH 310
S++GRPI ++KM++ +VKVPHTF +HSYTRPT+CQ CK+LLKGLFRQG+QCKDCKFNCH
Sbjct: 244 SSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCH 303
Query: 311 KRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKM 370
KRCA++VP DCLGE NG D+PM+ + +D S +D++E+
Sbjct: 304 KRCATRVPNDCLGEALING---------DVPMEEATDFSEADKSALMDESEDSGVIPGSH 354
Query: 371 FFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRD 430
+ L +EE + S+ IPLMRVVQS++HT RKSST ++EGW+VHY+++D
Sbjct: 355 ---SENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKD 411
Query: 431 NLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIIT 490
LRKRHYWRLD KC+TLFQN + ++YYKEIPLSEIL + S ++F+ + G+NPHCFEI+T
Sbjct: 412 TLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVT 471
Query: 491 DTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDH 550
YFVGE G + P +G G + A+ WE AIRQALMPV Q + ++PG H
Sbjct: 472 ANATYFVGEMPGGTPGGP----SGQGAEAARGWETAIRQALMPVILQDAP-SAPGHAP-H 525
Query: 551 KDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKM 610
+ S SISVSN QIQENVDI+TVYQIF DEVLGSGQFG+VYGGKHRKTGRDVA+KVIDK+
Sbjct: 526 RQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKL 585
Query: 611 RFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSR 670
RFPTKQESQLRNEVAILQ+L HPGIVNLECMFETPE+VFVVMEKLHGDMLEMILSSEK R
Sbjct: 586 RFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGR 645
Query: 671 LPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK 730
LPER+TKF++TQILVALR+LHFKNIVHCDLKPENVLLASA+PFPQVKLCDFGFARIIGEK
Sbjct: 646 LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK 705
Query: 731 SFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAA 790
SFRRSVVGTPAYLAPEVL ++GYNRSLDMWSVGVI+YVSLSGTFPFNEDEDINDQIQNAA
Sbjct: 706 SFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAA 765
Query: 791 FMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGE 850
FMYP +PW IS AIDLINNLLQVKMRKRYSVDKSLSHPWLQ+YQTWLDLRE E ++GE
Sbjct: 766 FMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGE 825
Query: 851 RYITHESDDARWEIHAYTHNL 871
RYITHESDDARWE A H L
Sbjct: 826 RYITHESDDARWEQFAAEHPL 846
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 961 bits (2483), Expect = 0.0
Identities = 482/707 (68%), Positives = 559/707 (79%), Gaps = 27/707 (3%)
Query: 174 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGP-----GLSVPRPL 228
ML+GLVRQGLKC+GCGLNYHKRCAF IPNNCSG RKRRLS+ SL G S P
Sbjct: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
Query: 229 QPEYVALPSEESHVHQEPSKR----IPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTI 284
E ++ + E + PS S++GRPI ++KM++ +VKVPHTF +HSYTRPT+
Sbjct: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
Query: 285 CQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDI 344
CQ CK+LLKGLFRQG+QCKDCKFNCHKRCA++VP DCLGE NG D+PM+
Sbjct: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALING---------DVPMEE 171
Query: 345 DNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVV 404
+ +D S +D++E+ + L +EE + S+ IPLMRVV
Sbjct: 172 ATDFSEADKSALMDESEDSGVIPGSH---SENALHASEEEEGEGGKAQSSLGYIPLMRVV 228
Query: 405 QSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSE 464
QS++HT RKSST ++EGW+VHY+++D LRKRHYWRLD KC+TLFQN + ++YYKEIPLSE
Sbjct: 229 QSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSE 288
Query: 465 ILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWE 524
IL + S ++F+ + G+NPHCFEI+T YFVGE G + P +G G + A+ WE
Sbjct: 289 ILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGP----SGQGAEAARGWE 344
Query: 525 KAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGS 584
AIRQALMPV Q + ++PG H+ S SISVSN QIQENVDI+TVYQIF DEVLGS
Sbjct: 345 TAIRQALMPVILQDAP-SAPGHAP-HRQASLSISVSNSQIQENVDIATVYQIFPDEVLGS 402
Query: 585 GQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFET 644
GQFG+VYGGKHRKTGRDVA+KVIDK+RFPTKQESQLRNEVAILQ+L HPGIVNLECMFET
Sbjct: 403 GQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFET 462
Query: 645 PERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPEN 704
PE+VFVVMEKLHGDMLEMILSSEK RLPER+TKF++TQILVALR+LHFKNIVHCDLKPEN
Sbjct: 463 PEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPEN 522
Query: 705 VLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGV 764
VLLASA+PFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL ++GYNRSLDMWSVGV
Sbjct: 523 VLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGV 582
Query: 765 IIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVD 824
I+YVSLSGTFPFNEDEDINDQIQNAAFMYP +PW IS AIDLINNLLQVKMRKRYSVD
Sbjct: 583 IMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVD 642
Query: 825 KSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNL 871
KSLSHPWLQ+YQTWLDLRE E ++GERYITHESDDARWE A H L
Sbjct: 643 KSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL 689
Score = 73.6 bits (179), Expect = 8e-13
Identities = 29/53 (54%), Positives = 37/53 (69%)
Query: 154 PHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSG 206
PHT +HSY PT C C ++L GL RQGL+C+ C N HKRCA ++PN+C G
Sbjct: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 191 bits (486), Expect = 2e-48
Identities = 111/286 (38%), Positives = 171/286 (59%), Gaps = 22/286 (7%)
Query: 568 VDISTVY------QIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQ-- 619
VD +VY + + LGSG G V RKT + VAIK+I K +F +
Sbjct: 249 VDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREAD 308
Query: 620 ----LRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPER 674
+ E+ IL+ L+HP I+ ++ F+ E ++V+E + G ++ + ++ ++ RL E
Sbjct: 309 PALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNK--RLKEA 365
Query: 675 ITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRR 734
K Q+L+A++ LH I+H DLKPENVLL+S E +K+ DFG ++I+GE S R
Sbjct: 366 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMR 425
Query: 735 SVVGTPAYLAPEVLRS---KGYNRSLDMWSVGVIIYVSLSGTFPFNEDE---DINDQIQN 788
++ GTP YLAPEVL S GYNR++D WS+GVI+++ LSG PF+E + DQI +
Sbjct: 426 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 485
Query: 789 AAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD 834
+ + P W E+S +A+DL+ LL V + R++ +++L HPWLQD
Sbjct: 486 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 531
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 191 bits (486), Expect = 2e-48
Identities = 111/286 (38%), Positives = 171/286 (59%), Gaps = 22/286 (7%)
Query: 568 VDISTVY------QIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQ-- 619
VD +VY + + LGSG G V RKT + VAIK+I K +F +
Sbjct: 206 VDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREAD 265
Query: 620 ----LRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPER 674
+ E+ IL+ L+HP I+ ++ F+ E ++V+E + G ++ + ++ ++ RL E
Sbjct: 266 PALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNK--RLKEA 322
Query: 675 ITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRR 734
K Q+L+A++ LH I+H DLKPENVLL+S E +K+ DFG ++I+GE S R
Sbjct: 323 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMR 382
Query: 735 SVVGTPAYLAPEVLRS---KGYNRSLDMWSVGVIIYVSLSGTFPFNEDE---DINDQIQN 788
++ GTP YLAPEVL S GYNR++D WS+GVI+++ LSG PF+E + DQI +
Sbjct: 383 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 442
Query: 789 AAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD 834
+ + P W E+S +A+DL+ LL V + R++ +++L HPWLQD
Sbjct: 443 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 488
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 179 bits (454), Expect = 1e-44
Identities = 103/259 (39%), Positives = 152/259 (58%), Gaps = 11/259 (4%)
Query: 581 VLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLEC 640
V+G G F +V +HR+T + A+K+IDK R K E + +E+ I+Q+L HP IV L
Sbjct: 361 VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGK-EDMVDSEILIIQSLSHPNIVKLHE 419
Query: 641 MFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCD 699
++ET +++++E + G D+ + I+ S K PE M+ + AL ++H K+IVH D
Sbjct: 420 VYETDMEIYLILEYVQGGDLFDAIIESVK--FPEPDAALMIMDLCKALVHMHDKSIVHRD 477
Query: 700 LKPENVLLASAEP-FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLD 758
LKPEN+L+ E +KL DFG A+ + F +V GTP Y+APE+L KGY +D
Sbjct: 478 LKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF--TVCGTPTYVAPEILSEKGYGLEVD 535
Query: 759 MWSVGVIIYVSLSGTFPFNEDEDINDQ----IQNAAFMYPPNPWREISGEAIDLINNLLQ 814
MW+ GVI+Y+ L G PF E D+ IQ F + P W IS A DL++ LL
Sbjct: 536 MWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLV 595
Query: 815 VKMRKRYSVDKSLSHPWLQ 833
V +KRY+ + L HPW++
Sbjct: 596 VDPKKRYTAHQVLQHPWIE 614
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 172 bits (436), Expect = 1e-42
Identities = 95/267 (35%), Positives = 156/267 (58%), Gaps = 8/267 (2%)
Query: 569 DISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQ 628
DI +++ E LG+G F V + + TG+ A+K I K K ES + NE+A+L+
Sbjct: 18 DIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESSIENEIAVLR 74
Query: 629 NLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVAL 687
+ H IV LE ++E+P +++VM+ + G ++ + I+ EK E+ ++ Q+L A+
Sbjct: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAV 132
Query: 688 RNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 747
LH IVH DLKPEN+L S + ++ + DFG +++ G+ + GTP Y+APEV
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
Query: 748 LRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEA 805
L K Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + W +IS A
Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
Query: 806 IDLINNLLQVKMRKRYSVDKSLSHPWL 832
D I NL++ KRY+ +++ HPW+
Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 172 bits (436), Expect = 1e-42
Identities = 95/267 (35%), Positives = 156/267 (58%), Gaps = 8/267 (2%)
Query: 569 DISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQ 628
DI +++ E LG+G F V + + TG+ A+K I K K ES + NE+A+L+
Sbjct: 18 DIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESSIENEIAVLR 74
Query: 629 NLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVAL 687
+ H IV LE ++E+P +++VM+ + G ++ + I+ EK E+ ++ Q+L A+
Sbjct: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAV 132
Query: 688 RNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 747
LH IVH DLKPEN+L S + ++ + DFG +++ G+ + GTP Y+APEV
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
Query: 748 LRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEA 805
L K Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + W +IS A
Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
Query: 806 IDLINNLLQVKMRKRYSVDKSLSHPWL 832
D I NL++ KRY+ +++ HPW+
Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 169 bits (428), Expect = 1e-41
Identities = 95/256 (37%), Positives = 154/256 (60%), Gaps = 8/256 (3%)
Query: 580 EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLE 639
EVLGSG F V+ K R TG+ A+K I K P ++S L NE+A+L+ + H IV LE
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKS--PAFRDSSLENEIAVLKKIKHENIVTLE 84
Query: 640 CMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHC 698
++E+ ++VM+ + G ++ + IL E+ E+ ++ Q+L A++ LH IVH
Sbjct: 85 DIYESTTHYYLVMQLVSGGELFDRIL--ERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142
Query: 699 DLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLD 758
DLKPEN+L + E ++ + DFG +++ + + GTP Y+APEVL K Y++++D
Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLAQKPYSKAVD 201
Query: 759 MWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLINNLLQVK 816
WS+GVI Y+ L G PF E+ + + ++I+ + + W +IS A D I +LL+
Sbjct: 202 CWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKD 261
Query: 817 MRKRYSVDKSLSHPWL 832
+RY+ +K+LSHPW+
Sbjct: 262 PNERYTCEKALSHPWI 277
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 166 bits (420), Expect = 9e-41
Identities = 102/261 (39%), Positives = 148/261 (56%), Gaps = 11/261 (4%)
Query: 580 EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLE 639
+V+G G F +V R TG++ A+K+IDK + K E + NEV+IL+ + HP I+ L
Sbjct: 397 KVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLV 455
Query: 640 CMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHC 698
ET +F+VME + G D+ + I SS K ER MV + ALR LH +IVH
Sbjct: 456 EEMETATELFLVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHR 513
Query: 699 DLKPENVLLAS-AEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSL 757
D+KPEN+L+ + +KL DFG A ++ + +V GTP Y+APE++ GY +
Sbjct: 514 DIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLY--TVCGTPTYVAPEIIAETGYGLKV 571
Query: 758 DMWSVGVIIYVSLSGTFPF----NEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLL 813
D+W+ GVI Y+ L G PF N ED+ DQI +P W I+ A +LI+ +L
Sbjct: 572 DIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 631
Query: 814 QVKMRKRYSVDKSLSHPWLQD 834
QV + R + + LSHPW+ D
Sbjct: 632 QVNVEARCTAGQILSHPWVSD 652
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 166 bits (420), Expect = 9e-41
Identities = 102/261 (39%), Positives = 148/261 (56%), Gaps = 11/261 (4%)
Query: 580 EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLE 639
+V+G G F +V R TG++ A+K+IDK + K E + NEV+IL+ + HP I+ L
Sbjct: 398 KVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLV 456
Query: 640 CMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHC 698
ET +F+VME + G D+ + I SS K ER MV + ALR LH +IVH
Sbjct: 457 EEMETATELFLVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHR 514
Query: 699 DLKPENVLLAS-AEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSL 757
D+KPEN+L+ + +KL DFG A ++ + +V GTP Y+APE++ GY +
Sbjct: 515 DIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLY--TVCGTPTYVAPEIIAETGYGLKV 572
Query: 758 DMWSVGVIIYVSLSGTFPF----NEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLL 813
D+W+ GVI Y+ L G PF N ED+ DQI +P W I+ A +LI+ +L
Sbjct: 573 DIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 632
Query: 814 QVKMRKRYSVDKSLSHPWLQD 834
QV + R + + LSHPW+ D
Sbjct: 633 QVNVEARCTAGQILSHPWVSD 653
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 166 bits (419), Expect = 1e-40
Identities = 96/255 (37%), Positives = 145/255 (56%), Gaps = 10/255 (3%)
Query: 582 LGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECM 641
LG G IVY K + T + A+KV+ K T + +R E+ +L L HP I+ L+ +
Sbjct: 52 LGRGATSIVYRCKQKGTQKPYALKVLKK----TVDKKIVRTEIGVLLRLSHPNIIKLKEI 107
Query: 642 FETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDL 700
FETP + +V+E + G ++ + I+ EK ER V QIL A+ LH IVH DL
Sbjct: 108 FETPTEISLVLELVTGGELFDRIV--EKGYYSERDAADAVKQILEAVAYLHENGIVHRDL 165
Query: 701 KPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMW 760
KPEN+L A+ P +K+ DFG ++I+ + ++V GTP Y APE+LR Y +DMW
Sbjct: 166 KPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMW 225
Query: 761 SVGVIIYVSLSGTFPFNE---DEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKM 817
SVG+I Y+ L G PF + D+ + +I N + + W E+S A DL+ L+ +
Sbjct: 226 SVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDP 285
Query: 818 RKRYSVDKSLSHPWL 832
+KR + ++L HPW+
Sbjct: 286 KKRLTTFQALQHPWV 300
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 165 bits (418), Expect = 2e-40
Identities = 94/267 (35%), Positives = 156/267 (58%), Gaps = 8/267 (2%)
Query: 569 DISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQ 628
DI +Y +VLG+G F V + ++T + VAIK I K K E + NE+A+L
Sbjct: 15 DIRDIYDF--RDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGK-EGSMENEIAVLH 71
Query: 629 NLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVAL 687
+ HP IV L+ ++E+ ++++M+ + G ++ + I+ EK ER ++ Q+L A+
Sbjct: 72 KIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIV--EKGFYTERDASRLIFQVLDAV 129
Query: 688 RNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 747
+ LH IVH DLKPEN+L S + ++ + DFG +++ S + GTP Y+APEV
Sbjct: 130 KYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEV 189
Query: 748 LRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEA 805
L K Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + W +IS A
Sbjct: 190 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSA 249
Query: 806 IDLINNLLQVKMRKRYSVDKSLSHPWL 832
D I +L++ KR++ +++L HPW+
Sbjct: 250 KDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 159 bits (402), Expect = 1e-38
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 15/309 (4%)
Query: 533 PVTPQ----ASVCTSPGQGKDHKDLSTSISVSNCQI--QENVDISTVYQIFADEVLGSGQ 586
P PQ A + G G H +I++ + + + DIS+VY+I E LGSG
Sbjct: 51 PAGPQLREAARASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEI--RERLGSGA 108
Query: 587 FGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE 646
F V + R + VA+K I K K E+ + NE+A+L+ + HP IV LE + E+P
Sbjct: 109 FSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAVLRRISHPNIVALEDVHESPS 167
Query: 647 RVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENV 705
+++ ME + G ++ + I+ E+ E+ +V Q+L A+ LH IVH DLKPEN+
Sbjct: 168 HLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENL 225
Query: 706 LLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVI 765
L A+ ++ + DFG ++I + GTP Y+APE+L K Y +++D+W++GVI
Sbjct: 226 LYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAPELLEQKPYGKAVDVWALGVI 284
Query: 766 IYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSV 823
Y+ L G PF ++ D + QI A++ + W +IS A D I +LL+ +KR++
Sbjct: 285 SYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTC 344
Query: 824 DKSLSHPWL 832
++L H W+
Sbjct: 345 QQALRHLWI 353
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 158 bits (399), Expect = 2e-38
Identities = 97/267 (36%), Positives = 155/267 (58%), Gaps = 9/267 (3%)
Query: 569 DISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQ 628
DIS+VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+L+
Sbjct: 27 DISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAVLR 83
Query: 629 NLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVAL 687
+ HP IV LE + E+P +++ ME + G ++ + I+ E+ E+ +V Q+L A+
Sbjct: 84 RISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLGAV 141
Query: 688 RNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 747
LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+APE+
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAPEL 200
Query: 748 LRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEA 805
L K Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + W +IS A
Sbjct: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
Query: 806 IDLINNLLQVKMRKRYSVDKSLSHPWL 832
D I +LL+ +KR++ ++L H W+
Sbjct: 261 KDFIRHLLERDPQKRFTCQQALRHLWI 287
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 157 bits (396), Expect = 5e-38
Identities = 94/263 (35%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V TG++ A K+I+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L ++V + + G ++ E I++ E E + QIL ++ + H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 810 NNLLQVKMRKRYSVDKSLSHPWL 832
N +L + KR + ++L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 157 bits (396), Expect = 5e-38
Identities = 94/263 (35%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V TG++ A K+I+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L ++V + + G ++ E I++ E E + QIL ++ + H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 810 NNLLQVKMRKRYSVDKSLSHPWL 832
N +L + KR + ++L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 157 bits (396), Expect = 5e-38
Identities = 94/263 (35%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V TG++ A K+I+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L ++V + + G ++ E I++ E E + QIL ++ + H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 810 NNLLQVKMRKRYSVDKSLSHPWL 832
N +L + KR + ++L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 157 bits (396), Expect = 5e-38
Identities = 94/263 (35%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V TG++ A K+I+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L ++V + + G ++ E I++ E E + QIL ++ + H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 810 NNLLQVKMRKRYSVDKSLSHPWL 832
N +L + KR + ++L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 157 bits (396), Expect = 5e-38
Identities = 94/263 (35%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V TG++ A K+I+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L ++V + + G ++ E I++ E E + QIL ++ + H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 810 NNLLQVKMRKRYSVDKSLSHPWL 832
N +L + KR + ++L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 157 bits (396), Expect = 5e-38
Identities = 94/263 (35%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V TG++ A K+I+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L ++V + + G ++ E I++ E E + QIL ++ + H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 810 NNLLQVKMRKRYSVDKSLSHPWL 832
N +L + KR + ++L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 153 bits (387), Expect = 6e-37
Identities = 94/259 (36%), Positives = 145/259 (55%), Gaps = 11/259 (4%)
Query: 582 LGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECM 641
+G G F +V R T R+ A+K+I K + K E ++NEV+IL+ + HP IV L
Sbjct: 396 IGDGNFAVVKECVERSTAREYALKIIKKSKCRGK-EHMIQNEVSILRRVKHPNIVLLIEE 454
Query: 642 FETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDL 700
+ P +++VME + G D+ + I S+ K ER M+ + A++ LH NIVH D+
Sbjct: 455 MDVPTELYLVMELVKGGDLFDAITSTNK--YTERDASGMLYNLASAIKYLHSLNIVHRDI 512
Query: 701 KPENVLLASAEPFPQ-VKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDM 759
KPEN+L+ + + +KL DFG A I+ + +V GTP Y+APE++ GY +D+
Sbjct: 513 KPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY--TVCGTPTYVAPEIIAETGYGLKVDI 570
Query: 760 WSVGVIIYVSLSGTFPF----NEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQV 815
W+ GVI Y+ L G PF ++ E + DQI +P W +S A +LI +L V
Sbjct: 571 WAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLV 630
Query: 816 KMRKRYSVDKSLSHPWLQD 834
+ +R+S + L HPW+ D
Sbjct: 631 DVDQRFSAVQVLEHPWVND 649
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 152 bits (385), Expect = 1e-36
Identities = 97/263 (36%), Positives = 144/263 (54%), Gaps = 12/263 (4%)
Query: 580 EVLGSGQFGIVYGGKHR-KTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNL 638
+++G G F +V+ G+HR KT +VAIK I+K +K + L E+ IL+ L H IV L
Sbjct: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
Query: 639 ECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHC 698
+ E P VF+VME +G L L + K L E + + QI A+R LH K I+H
Sbjct: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
Query: 699 DLKPENVLLASAEPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG 752
DLKP+N+LL+ A ++K+ DFGFAR + ++ G+P Y+APEV+ S+
Sbjct: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
Query: 753 YNRSLDMWSVGVIIYVSLSGTFPF--NEDEDINDQIQNAAFMYPPNPWREISGEAIDLIN 810
Y+ D+WS+G +IY L G PF N +D+ + + P P RE S +L+
Sbjct: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Query: 811 NLLQVKMRKRYSVDKSLSHPWLQ 833
LLQ + R + SHP+L+
Sbjct: 250 GLLQRNQKDRMDFEAFFSHPFLE 272
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 152 bits (385), Expect = 1e-36
Identities = 97/263 (36%), Positives = 144/263 (54%), Gaps = 12/263 (4%)
Query: 580 EVLGSGQFGIVYGGKHR-KTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNL 638
+++G G F +V+ G+HR KT +VAIK I+K +K + L E+ IL+ L H IV L
Sbjct: 13 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNL-SKSQILLGKEIKILKELQHENIVAL 71
Query: 639 ECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHC 698
+ E P VF+VME +G L L + K L E + + QI A+R LH K I+H
Sbjct: 72 YDVQELPNSVFLVMEYCNGGDLADYLQA-KGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 130
Query: 699 DLKPENVLLASAEPFP------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG 752
DLKP+N+LL+ A ++K+ DFGFAR + ++ G+P Y+APEV+ S+
Sbjct: 131 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQH 190
Query: 753 YNRSLDMWSVGVIIYVSLSGTFPF--NEDEDINDQIQNAAFMYPPNPWREISGEAIDLIN 810
Y+ D+WS+G +IY L G PF N +D+ + + P P RE S +L+
Sbjct: 191 YDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIP-RETSPYLANLLL 249
Query: 811 NLLQVKMRKRYSVDKSLSHPWLQ 833
LLQ + R + SHP+L+
Sbjct: 250 GLLQRNQKDRMDFEAFFSHPFLE 272
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 152 bits (384), Expect = 1e-36
Identities = 93/268 (34%), Positives = 141/268 (52%), Gaps = 8/268 (2%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V G++ A K+I+ + + +L E I + L HP
Sbjct: 13 YQLF--EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L +++ + + G ++ E I++ E E + QIL A+ + H
Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQ 128
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
+VH DLKPEN+LLAS VKL DFG A + GE+ GTP YL+PEVLR
Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +D+W+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248
Query: 810 NNLLQVKMRKRYSVDKSLSHPWLQDYQT 837
N +L + KR + ++L HPW+ T
Sbjct: 249 NKMLTINPSKRITAAEALKHPWISHRST 276
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 152 bits (384), Expect = 1e-36
Identities = 93/268 (34%), Positives = 141/268 (52%), Gaps = 8/268 (2%)
Query: 574 YQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHP 633
YQ+F E LG G F +V G++ A K+I+ + + +L E I + L HP
Sbjct: 13 YQLF--EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70
Query: 634 GIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPERITKFMVTQILVALRNLHF 692
IV L +++ + + G ++ E I++ E E + QIL A+ + H
Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQ 128
Query: 693 KNIVHCDLKPENVLLASAEPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRSK 751
+VH DLKPEN+LLAS VKL DFG A + GE+ GTP YL+PEVLR
Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188
Query: 752 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--INDQIQNAAFMYPPNPWREISGEAIDLI 809
Y + +D+W+ GVI+Y+ L G PF +++ + QI+ A+ +P W ++ EA DLI
Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248
Query: 810 NNLLQVKMRKRYSVDKSLSHPWLQDYQT 837
N +L + KR + ++L HPW+ T
Sbjct: 249 NKMLTINPSKRITAAEALKHPWISHRST 276
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 152 bits (383), Expect = 2e-36
Identities = 97/293 (33%), Positives = 151/293 (51%), Gaps = 11/293 (3%)
Query: 570 ISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQN 629
++ Y I A ++G G F V +HR T + AIK+I+ ++ + +E+ +L+
Sbjct: 94 VTAKYDIKA--LIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCE--SELRVLRR 149
Query: 630 LHHPGIVNLECMFETPERVFVVME-KLHGDMLEMILSSEKSRLPERITKFMVTQILVALR 688
+ H I+ L +FET ERV++VME G++ + I++ K ER ++ +L +R
Sbjct: 150 VRHANIIQLVEVFETQERVYMVMELATGGELFDRIIA--KGSFTERDATRVLQMVLDGVR 207
Query: 689 NLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFA--RIIGEKSFRRSVVGTPAYLAPE 746
LH I H DLKPEN+L ++ + DFG A R G+ ++ GTP Y+APE
Sbjct: 208 YLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPE 267
Query: 747 VLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE--DINDQIQNAAFMYPPNPWREISGE 804
VL K Y S+DMW++GVI Y+ LSGT PF +D + QI + Y PW +S
Sbjct: 268 VLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNL 327
Query: 805 AIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHES 857
A D I+ LL V R + ++L HPW+ ++ I + + S
Sbjct: 328 AKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRAS 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,685,318
Number of Sequences: 37866
Number of extensions: 1793063
Number of successful extensions: 8847
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 597
Number of HSP's successfully gapped in prelim test: 273
Number of HSP's that attempted gapping in prelim test: 5937
Number of HSP's gapped (non-prelim): 1435
length of query: 890
length of database: 18,247,518
effective HSP length: 111
effective length of query: 779
effective length of database: 14,044,392
effective search space: 10940581368
effective search space used: 10940581368
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.