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Search of human proteins with 50083291
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50083291 amyloid beta A4 precursor protein-binding, family
B, member 2 [Homo sapiens]
(736 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50083291 amyloid beta A4 precursor protein-binding, family B,... 1495 0.0
gi|22035554 amyloid beta A4 precursor protein-binding, family B,... 574 e-164
gi|4502131 amyloid beta A4 precursor protein-binding, family B, ... 569 e-162
gi|95147542 amyloid beta precursor protein-binding, family B, me... 379 e-105
gi|95147540 amyloid beta precursor protein-binding, family B, me... 374 e-103
gi|95147536 amyloid beta precursor protein-binding, family B, me... 372 e-103
gi|95147538 amyloid beta precursor protein-binding, family B, me... 371 e-102
gi|114520607 neural precursor cell expressed, developmentally do... 46 1e-04
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 44 4e-04
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 43 0.001
gi|54144629 numb homolog isoform 4 [Homo sapiens] 43 0.001
gi|20070356 numb homolog isoform 3 [Homo sapiens] 43 0.001
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom... 40 0.006
gi|4885433 mitogen-activated protein kinase 8 interacting protei... 40 0.006
gi|114520609 neural precursor cell expressed, developmentally do... 40 0.006
gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens] 40 0.010
gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens] 40 0.010
gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens] 40 0.010
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 39 0.013
gi|222352183 neural precursor cell expressed, developmentally do... 39 0.017
gi|21361472 neural precursor cell expressed, developmentally dow... 39 0.017
gi|222352094 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352092 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352090 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352088 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352086 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352084 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352082 neural precursor cell expressed, developmentally do... 39 0.017
gi|222352122 hypothetical protein LOC284297 [Homo sapiens] 38 0.029
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 37 0.050
>gi|50083291 amyloid beta A4 precursor protein-binding, family B,
member 2 [Homo sapiens]
Length = 736
Score = 1495 bits (3870), Expect = 0.0
Identities = 736/736 (100%), Positives = 736/736 (100%)
Query: 1 MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLNAEIKHTETKN 60
MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLNAEIKHTETKN
Sbjct: 1 MSEVLPADSGVDTLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLNAEIKHTETKN 60
Query: 61 STPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNK 120
STPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNK
Sbjct: 61 STPPKCRKKYALTNIQAAMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNK 120
Query: 121 NLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG 180
NLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG
Sbjct: 121 NLSPTAVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG 180
Query: 181 NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTG 240
NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTG
Sbjct: 181 NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKDHPKTG 240
Query: 241 AKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVS 300
AKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVS
Sbjct: 241 AKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVS 300
Query: 301 DIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSL 360
DIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSL
Sbjct: 301 DIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPDPSL 360
Query: 361 KEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSV 420
KEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSV
Sbjct: 361 KEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAKCFAVRSLGWVEMAEEDLAPGKSSV 420
Query: 421 AVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVW 480
AVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVW
Sbjct: 421 AVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVW 480
Query: 481 GVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALACS 540
GVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALACS
Sbjct: 481 GVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNAKALACS 540
Query: 541 SLQERANVNLDVPLQDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNK 600
SLQERANVNLDVPLQDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNK
Sbjct: 541 SLQERANVNLDVPLQDFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNK 600
Query: 601 EDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC 660
EDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC
Sbjct: 601 EDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFEC 660
Query: 661 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVL 720
HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVL
Sbjct: 661 HVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTTNVKRGVL 720
Query: 721 SLIDTLKQKRPVTEMP 736
SLIDTLKQKRPVTEMP
Sbjct: 721 SLIDTLKQKRPVTEMP 736
>gi|22035554 amyloid beta A4 precursor protein-binding, family B,
member 1 isoform delta E9 [Homo sapiens]
Length = 708
Score = 574 bits (1480), Expect = e-164
Identities = 344/737 (46%), Positives = 457/737 (62%), Gaps = 65/737 (8%)
Query: 20 SSGTTDVTNRNSPATPPNTLNL--RSSHNELLNAEIKHTETKNSTPPKCRKKYALTNIQA 77
SS + N NS P +L L ++HN+LLNA+++ T + PK ++++
Sbjct: 5 SSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQAT----AVGPK--------DLRS 52
Query: 78 AMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNKNLSPTAVINITSEKLEG 137
AMG +P G AN K +K G+NQLR+AA +D N+N + +T +
Sbjct: 53 AMG-EGGGPEP----GPANAKWLKEGQNQLRRAAT-AHRDQNRN------VTLTLAEEAS 100
Query: 138 KEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG---------NHHGTAEE 188
+EP E+ P P K ++ Y++LE SA NRG +E
Sbjct: 101 QEP--------EMAPLGP---KGLIHLYSELELSAHNAA-NRGLRGPGLIISTQEQGPDE 148
Query: 189 KSQPVQGQASTIIGNGDLLLQKPN--RPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCA 246
+ G+A + D ++ + P PE + P+ D P+ +K+
Sbjct: 149 GEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASL 208
Query: 247 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETD-IWSDHSFQTDPDLPPGWKRVSDIAGT 305
L ++N A SDE+SSW TLSQ S S SP++TD W+ ++F+TD DLP GW RV D +GT
Sbjct: 209 LFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGT 268
Query: 306 YYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPD-PS----- 359
YYWHIPTGTTQWE P + QGS S +T + E D PS
Sbjct: 269 YYWHIPTGTTQWEPP-GRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPM 327
Query: 360 ---LKEFEGATLRYASLKLRNAPHPDDDDSCSI-NSDPEAKCFAVRSLGWVEMAEEDLAP 415
LKE E TL + + L P P +++ N++P KCFAVRSLGWVEM EE+LAP
Sbjct: 328 ELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAP 387
Query: 416 GKSSVAVNNCIRQLSYCKNDIRDTV-GIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPI 474
G+SSVAVNNCIRQLSY KN++ D + G WGEGKD+ L LE++ L LV+P +++LH+QPI
Sbjct: 388 GRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPI 447
Query: 475 VSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERKNA 534
+SIRVWGVGRD+GRDFAYVARDK T++LKCHVFRC+ PAK IATSLHEICSKIMAER+NA
Sbjct: 448 ISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNA 507
Query: 535 KALACSSLQERANVNLDVPLQ-DFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAIEN 593
+ L + + + +DVP Q +FP PK ELVQKF V YLG +PV KPVG+D++N A+E+
Sbjct: 508 RCLVNGLSLDHSKL-VDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALES 566
Query: 594 LMTSSNKEDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIMDT 653
+++SS++E W +++VA AT+T++ ++ E VL ECRVRFLSF+ VG+DVHTFAFIM
Sbjct: 567 VLSSSSREQWTPSHVSVAPATLTILHQQT-EAVLGECRVRFLSFLAVGRDVHTFAFIMAA 625
Query: 654 GNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRVTT 713
G F CH+FWCEPNA ++SEAVQAACMLRYQKCL AR + P PPA+SV RRV
Sbjct: 626 GPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGW 685
Query: 714 NVKRGVLSLIDTLKQKR 730
V+RGV SL +LK KR
Sbjct: 686 TVRRGVQSLWGSLKPKR 702
>gi|4502131 amyloid beta A4 precursor protein-binding, family B,
member 1 isoform E9 [Homo sapiens]
Length = 710
Score = 569 bits (1467), Expect = e-162
Identities = 344/739 (46%), Positives = 457/739 (61%), Gaps = 67/739 (9%)
Query: 20 SSGTTDVTNRNSPATPPNTLNL--RSSHNELLNAEIKHTETKNSTPPKCRKKYALTNIQA 77
SS + N NS P +L L ++HN+LLNA+++ T + PK ++++
Sbjct: 5 SSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQAT----AVGPK--------DLRS 52
Query: 78 AMGLSDPAAQPLLGNGSANIKLVKNGENQLRKAAEQGQQDPNKNLSPTAVINITSEKLEG 137
AMG +P G AN K +K G+NQLR+AA +D N+N + +T +
Sbjct: 53 AMG-EGGGPEP----GPANAKWLKEGQNQLRRAAT-AHRDQNRN------VTLTLAEEAS 100
Query: 138 KEPHPQDSSSCEILPSQPRRTKSFLNYYADLETSARELEQNRG---------NHHGTAEE 188
+EP E+ P P K ++ Y++LE SA NRG +E
Sbjct: 101 QEP--------EMAPLGP---KGLIHLYSELELSAHNAA-NRGLRGPGLIISTQEQGPDE 148
Query: 189 KSQPVQGQASTIIGNGDLLLQKPN--RPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCA 246
+ G+A + D ++ + P PE + P+ D P+ +K+
Sbjct: 149 GEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASL 208
Query: 247 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETD-IWSDHSFQTDPDLPPGWKRVSDIAGT 305
L ++N A SDE+SSW TLSQ S S SP++TD W+ ++F+TD DLP GW RV D +GT
Sbjct: 209 LFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGT 268
Query: 306 YYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAATVNPD-PS----- 359
YYWHIPTGTTQWE P + QGS S +T + E D PS
Sbjct: 269 YYWHIPTGTTQWEPP-GRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPM 327
Query: 360 ---LKEFEGATLRYASLKLRNAPHPDDDDSCSI-NSDPEAKCFAVRSLGWVEMAEEDLAP 415
LKE E TL + + L P P +++ N++P KCFAVRSLGWVEM EE+LAP
Sbjct: 328 ELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAP 387
Query: 416 GKSSVAVNNCIRQLSYCKNDIRDTV-GIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPI 474
G+SSVAVNNCIRQLSY KN++ D + G WGEGKD+ L LE++ L LV+P +++LH+QPI
Sbjct: 388 GRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPI 447
Query: 475 VSIRVWGVGRDNGR--DFAYVARDKDTRILKCHVFRCDTPAKAIATSLHEICSKIMAERK 532
+SIRVWGVGRD+GR DFAYVARDK T++LKCHVFRC+ PAK IATSLHEICSKIMAER+
Sbjct: 448 ISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERR 507
Query: 533 NAKALACSSLQERANVNLDVPLQ-DFPTPKTELVQKFHVQYLGMLPVDKPVGMDILNSAI 591
NA+ L + + + +DVP Q +FP PK ELVQKF V YLG +PV KPVG+D++N A+
Sbjct: 508 NARCLVNGLSLDHSKL-VDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGAL 566
Query: 592 ENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVLVECRVRFLSFMGVGKDVHTFAFIM 651
E++++SS++E W +++VA AT+T++ ++ E VL ECRVRFLSF+ VG+DVHTFAFIM
Sbjct: 567 ESVLSSSSREQWTPSHVSVAPATLTILHQQTEA-VLGECRVRFLSFLAVGRDVHTFAFIM 625
Query: 652 DTGNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLVARPPSQKVRPPPPPADSVTRRV 711
G F CH+FWCEPNA ++SEAVQAACMLRYQKCL AR + P PPA+SV RRV
Sbjct: 626 AAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRV 685
Query: 712 TTNVKRGVLSLIDTLKQKR 730
V+RGV SL +LK KR
Sbjct: 686 GWTVRRGVQSLWGSLKPKR 704
>gi|95147542 amyloid beta precursor protein-binding, family B,
member 3 isoform a [Homo sapiens]
Length = 484
Score = 379 bits (973), Expect = e-105
Identities = 203/488 (41%), Positives = 280/488 (57%), Gaps = 47/488 (9%)
Query: 277 ETDIWSDHSFQTDPDLPPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLS 336
+ D+W DHS + + LPPGW+++ D AGTYYWH+P+G+TQW+RP D + G+
Sbjct: 16 DDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGT-- 73
Query: 337 SVTPSPTPENEDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAK 396
E + S E + R SL +S + +P AK
Sbjct: 74 ----------EGIWGLRPPKGRSFSSLESSLDRSNSLSWYGG------ESYIQSMEPGAK 117
Query: 397 CFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILEND 456
CFAVRSLGWVE+ EEDLAPGKSS+AVNNCI+QL+ ++ + G WGEG++M +IL+ D
Sbjct: 118 CFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKD 177
Query: 457 MLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDKDTRILKCHVFRCDTPAKAI 516
+SLV+P+D S++H QP+V IRVWGVG GRDFA+VA DKD+ +LKCHVF CD PAKAI
Sbjct: 178 AMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDFAFVASDKDSCMLKCHVFCCDVPAKAI 237
Query: 517 ATSLHEICSKIMAERKNAKALACSSLQERANVNLDVPLQ-DFPTPKTELVQKFHVQYLGM 575
A++LH +C++I++ER A + + D+P Q + ++ QK+ Y+G
Sbjct: 238 ASALHGLCAQILSERVEVSGDASCCSPDPISPE-DLPRQVELLDAVSQAAQKYEALYMGT 296
Query: 576 LPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTV----ISEKNEEEVLVECR 631
LPV K +GMD+LN AI L ++ W+ ++V+D+ +T EEE L +C
Sbjct: 297 LPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCP 356
Query: 632 VRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLVAR 691
VR ++F+GVG+D HTF I D G Q F+C FWC+P+AG +SEAVQAACM++YQKCLVA
Sbjct: 357 VRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVAS 416
Query: 692 PPSQKV-----------------------RPPPPPADSVTRRVTTNVKRGVLSLIDTLKQ 728
K P P V T KRGV S +D +
Sbjct: 417 AARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRL 476
Query: 729 KRPVTEMP 736
K + MP
Sbjct: 477 KPSLLHMP 484
>gi|95147540 amyloid beta precursor protein-binding, family B,
member 3 isoform b [Homo sapiens]
Length = 486
Score = 374 bits (960), Expect = e-103
Identities = 203/490 (41%), Positives = 280/490 (57%), Gaps = 49/490 (10%)
Query: 277 ETDIWSDHSFQTDPDLPPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLS 336
+ D+W DHS + + LPPGW+++ D AGTYYWH+P+G+TQW+RP D + G+
Sbjct: 16 DDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGT-- 73
Query: 337 SVTPSPTPENEDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAK 396
E + S E + R SL +S + +P AK
Sbjct: 74 ----------EGIWGLRPPKGRSFSSLESSLDRSNSLSWYGG------ESYIQSMEPGAK 117
Query: 397 CFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILEND 456
CFAVRSLGWVE+ EEDLAPGKSS+AVNNCI+QL+ ++ + G WGEG++M +IL+ D
Sbjct: 118 CFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKD 177
Query: 457 MLSLVDPMDRSVLHSQPIVSIRVWGVGRDNG--RDFAYVARDKDTRILKCHVFRCDTPAK 514
+SLV+P+D S++H QP+V IRVWGVG G RDFA+VA DKD+ +LKCHVF CD PAK
Sbjct: 178 AMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAK 237
Query: 515 AIATSLHEICSKIMAERKNAKALACSSLQERANVNLDVPLQ-DFPTPKTELVQKFHVQYL 573
AIA++LH +C++I++ER A + + D+P Q + ++ QK+ Y+
Sbjct: 238 AIASALHGLCAQILSERVEVSGDASCCSPDPISPE-DLPRQVELLDAVSQAAQKYEALYM 296
Query: 574 GMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTV----ISEKNEEEVLVE 629
G LPV K +GMD+LN AI L ++ W+ ++V+D+ +T EEE L +
Sbjct: 297 GTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQ 356
Query: 630 CRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACMLRYQKCLV 689
C VR ++F+GVG+D HTF I D G Q F+C FWC+P+AG +SEAVQAACM++YQKCLV
Sbjct: 357 CPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLV 416
Query: 690 ARPPSQKV-----------------------RPPPPPADSVTRRVTTNVKRGVLSLIDTL 726
A K P P V T KRGV S +D
Sbjct: 417 ASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAF 476
Query: 727 KQKRPVTEMP 736
+ K + MP
Sbjct: 477 RLKPSLLHMP 486
>gi|95147536 amyloid beta precursor protein-binding, family B,
member 3 isoform c [Homo sapiens]
Length = 491
Score = 372 bits (955), Expect = e-103
Identities = 203/495 (41%), Positives = 280/495 (56%), Gaps = 54/495 (10%)
Query: 277 ETDIWSDHSFQTDPDLPPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLS 336
+ D+W DHS + + LPPGW+++ D AGTYYWH+P+G+TQW+RP D + G+
Sbjct: 16 DDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGT-- 73
Query: 337 SVTPSPTPENEDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAK 396
E + S E + R SL +S + +P AK
Sbjct: 74 ----------EGIWGLRPPKGRSFSSLESSLDRSNSLSWYGG------ESYIQSMEPGAK 117
Query: 397 CFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILEND 456
CFAVRSLGWVE+ EEDLAPGKSS+AVNNCI+QL+ ++ + G WGEG++M +IL+ D
Sbjct: 118 CFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKD 177
Query: 457 MLSLVDPMDRSVLHSQPIVSIRVWGVGRDNG-------RDFAYVARDKDTRILKCHVFRC 509
+SLV+P+D S++H QP+V IRVWGVG G RDFA+VA DKD+ +LKCHVF C
Sbjct: 178 AMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRPISAPARDFAFVASDKDSCMLKCHVFCC 237
Query: 510 DTPAKAIATSLHEICSKIMAERKNAKALACSSLQERANVNLDVPLQ-DFPTPKTELVQKF 568
D PAKAIA++LH +C++I++ER A + + D+P Q + ++ QK+
Sbjct: 238 DVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPE-DLPRQVELLDAVSQAAQKY 296
Query: 569 HVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTV----ISEKNEE 624
Y+G LPV K +GMD+LN AI L ++ W+ ++V+D+ +T EE
Sbjct: 297 EALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEE 356
Query: 625 EVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACMLRY 684
E L +C VR ++F+GVG+D HTF I D G Q F+C FWC+P+AG +SEAVQAACM++Y
Sbjct: 357 EPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQY 416
Query: 685 QKCLVARPPSQKV-----------------------RPPPPPADSVTRRVTTNVKRGVLS 721
QKCLVA K P P V T KRGV S
Sbjct: 417 QKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFS 476
Query: 722 LIDTLKQKRPVTEMP 736
+D + K + MP
Sbjct: 477 FLDAFRLKPSLLHMP 491
>gi|95147538 amyloid beta precursor protein-binding, family B,
member 3 isoform d [Homo sapiens]
Length = 493
Score = 371 bits (953), Expect = e-102
Identities = 203/497 (40%), Positives = 280/497 (56%), Gaps = 56/497 (11%)
Query: 277 ETDIWSDHSFQTDPDLPPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLS 336
+ D+W DHS + + LPPGW+++ D AGTYYWH+P+G+TQW+RP D + G+
Sbjct: 16 DDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGT-- 73
Query: 337 SVTPSPTPENEDLHAATVNPDPSLKEFEGATLRYASLKLRNAPHPDDDDSCSINSDPEAK 396
E + S E + R SL +S + +P AK
Sbjct: 74 ----------EGIWGLRPPKGRSFSSLESSLDRSNSLSWYGG------ESYIQSMEPGAK 117
Query: 397 CFAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIRDTVGIWGEGKDMYLILEND 456
CFAVRSLGWVE+ EEDLAPGKSS+AVNNCI+QL+ ++ + G WGEG++M +IL+ D
Sbjct: 118 CFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKD 177
Query: 457 MLSLVDPMDRSVLHSQPIVSIRVWGVGRDNG---------RDFAYVARDKDTRILKCHVF 507
+SLV+P+D S++H QP+V IRVWGVG G RDFA+VA DKD+ +LKCHVF
Sbjct: 178 AMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDSPISAPARDFAFVASDKDSCMLKCHVF 237
Query: 508 RCDTPAKAIATSLHEICSKIMAERKNAKALACSSLQERANVNLDVPLQ-DFPTPKTELVQ 566
CD PAKAIA++LH +C++I++ER A + + D+P Q + ++ Q
Sbjct: 238 CCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPE-DLPRQVELLDAVSQAAQ 296
Query: 567 KFHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTV----ISEKN 622
K+ Y+G LPV K +GMD+LN AI L ++ W+ ++V+D+ +T
Sbjct: 297 KYEALYMGTLPVTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEAST 356
Query: 623 EEEVLVECRVRFLSFMGVGKDVHTFAFIMDTGNQRFECHVFWCEPNAGNVSEAVQAACML 682
EEE L +C VR ++F+GVG+D HTF I D G Q F+C FWC+P+AG +SEAVQAACM+
Sbjct: 357 EEEPLWQCPVRLVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMV 416
Query: 683 RYQKCLVARPPSQKV-----------------------RPPPPPADSVTRRVTTNVKRGV 719
+YQKCLVA K P P V T KRGV
Sbjct: 417 QYQKCLVASAARGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGV 476
Query: 720 LSLIDTLKQKRPVTEMP 736
S +D + K + MP
Sbjct: 477 FSFLDAFRLKPSLLHMP 493
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 45.8 bits (107), Expect = 1e-04
Identities = 81/335 (24%), Positives = 128/335 (38%), Gaps = 57/335 (17%)
Query: 13 TLAVFMASSGTTDVTNRNSPATPPNTLNLRSSHNELLN-AEIKHTETKNSTPPKCRKKYA 71
+L +F S TT T+ S T + + ++SH +++ +EI H E + T K A
Sbjct: 265 SLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFIISPSEIAHNE--DGTSAKGFLSTA 322
Query: 72 LTNIQAAMGLSDPAA----QPLLGNGSANIKLV------------KNGENQL-------- 107
+ ++ + + P +PL GS K+V K+ E
Sbjct: 323 VNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNTPRQTVCEKSSEGYSCVSVHFTQ 382
Query: 108 RKAAEQGQQDPNKNLSPT-AVINITSEKLEGKEPHPQDSSSCEILPSQPRRTKSFLNYYA 166
RKAA + N + P + I + S+ K H +S+C LPS + +N
Sbjct: 383 RKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHR--TSAC--LPSS-QNVDCQINING 437
Query: 167 DLETSARELEQNRGNHHGTAEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATV 226
+LE ++ +N G +S + G I L K N + P +
Sbjct: 438 ELERPHSQMNKNHG-----ILRRSISLGGAYPNISCLSSL---KHNCSKGGPSQLLIKFA 489
Query: 227 SSSPETKKDHPKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSF 286
S + E K D+ + DC + P W L Q A+ +
Sbjct: 490 SGN-EGKVDNLSRDSNRDCTNELSNSCKPG-----WVVLDQPDAACHLQQQ--------- 534
Query: 287 QTDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERP 320
Q LPPGW+ DI G TYY + + TQW+RP
Sbjct: 535 QEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
Score = 33.9 bits (76), Expect = 0.56
Identities = 50/223 (22%), Positives = 79/223 (35%), Gaps = 33/223 (14%)
Query: 181 NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPN----RPQSSPEDGQVATVSSSPE---TK 233
NH + +P T NG++ LQ R Q S E V SS +
Sbjct: 558 NHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIR 617
Query: 234 KDH-----------PKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWS 282
+D P + D H + L + +SQ ++S +
Sbjct: 618 EDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQ 677
Query: 283 DHSFQTDPDLP----------PGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPADLQGSR 331
++F+ P LP PGW+ D G +YY + TT W +P ++ A ++ S+
Sbjct: 678 AYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKP-TVQATVETSQ 736
Query: 332 -KGSLSSVTPSPTPENEDLHAATVNPDPSLKEF--EGATLRYA 371
S SS P D P + F +G +R+A
Sbjct: 737 LTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHA 779
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 44.3 bits (103), Expect = 4e-04
Identities = 34/115 (29%), Positives = 49/115 (42%), Gaps = 2/115 (1%)
Query: 211 PNRPQSSPEDGQVATVSSSPETKKDHPKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSA 270
PN ++ ED V + +S E + P T A+ + I S+ SS + S
Sbjct: 271 PNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSR 330
Query: 271 SPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIP 324
P + + T+ LP GW++ D G TYY T TT WERP +P
Sbjct: 331 QPDGCMDPVRQQSGNANTET-LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLP 384
Score = 33.5 bits (75), Expect = 0.73
Identities = 18/37 (48%), Positives = 21/37 (56%), Gaps = 3/37 (8%)
Query: 287 QTDP--DLPPGW-KRVSDIAGTYYWHIPTGTTQWERP 320
+ DP LPPGW KRV Y+ + T TTQWE P
Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDP 487
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 42.7 bits (99), Expect = 0.001
Identities = 52/214 (24%), Positives = 82/214 (38%), Gaps = 36/214 (16%)
Query: 136 EGKEPHPQDSSSCEILPS---QPRRTKSF---LNYYADLETSARELEQNRGNHHGTAEEK 189
+G + +DSS + P QP T F + SAR G
Sbjct: 159 DGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRH 218
Query: 190 SQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQVATVSSSPETKKD---HPKTGAKTDCA 246
QPV+ + + NG + + PE+ V V+S P +P T + A
Sbjct: 219 RQPVKNSGHSGLANGTV--NDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPA 276
Query: 247 LHRIQNLAPSD-EESSWTTLSQDSASPSSPDETDI-------------WSDHSFQT---D 289
P++ EE S + Q A+ +PD + DH+ +T +
Sbjct: 277 -------TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWE 329
Query: 290 PDLPPGWKRVSDIAGTYYW-HIPTGTTQWERPVS 322
LPPGW++ +D G +Y+ T TT W+RP +
Sbjct: 330 RPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTA 363
Score = 38.1 bits (87), Expect = 0.029
Identities = 19/45 (42%), Positives = 24/45 (53%), Gaps = 4/45 (8%)
Query: 280 IWSDHSFQTDPD----LPPGWKRVSDIAGTYYWHIPTGTTQWERP 320
++ S TD D LPPGW++ D YY + T TTQWE P
Sbjct: 391 LYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDP 435
>gi|54144629 numb homolog isoform 4 [Homo sapiens]
Length = 592
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/125 (29%), Positives = 64/125 (51%), Gaps = 9/125 (7%)
Query: 568 FHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVL 627
F V+YLG + VD+ GM I A++ L + K + + V+ + V+ EK ++++
Sbjct: 39 FPVKYLGHVEVDESRGMHICEDAVKRLKATGKKA--VKAVLWVSADGLRVVDEKT-KDLI 95
Query: 628 VECRVRFLSFMGVGKDV-HTFAFIMDTG-NQRFECHVFWCEPNAG-NVSEAVQ---AACM 681
V+ + +SF ++ F++I G +R+ CH F + G +S AV AAC+
Sbjct: 96 VDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACL 155
Query: 682 LRYQK 686
R QK
Sbjct: 156 ERKQK 160
Score = 36.2 bits (82), Expect = 0.11
Identities = 32/130 (24%), Positives = 51/130 (39%), Gaps = 19/130 (14%)
Query: 379 PHPDDDDSCSINSDPEAKC-FAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIR 437
PH D + + KC F V+ LG VE+ E R + C++ ++
Sbjct: 22 PHQWQTDEEGVRT---GKCSFPVKYLGHVEVDES---------------RGMHICEDAVK 63
Query: 438 DTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDK 497
+ L + D L +VD + ++ Q I + R+ R F+Y+ RD
Sbjct: 64 RLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDG 123
Query: 498 DTRILKCHVF 507
TR CH F
Sbjct: 124 TTRRWICHCF 133
>gi|20070356 numb homolog isoform 3 [Homo sapiens]
Length = 640
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/125 (29%), Positives = 64/125 (51%), Gaps = 9/125 (7%)
Query: 568 FHVQYLGMLPVDKPVGMDILNSAIENLMTSSNKEDWLSVNMNVADATVTVISEKNEEEVL 627
F V+YLG + VD+ GM I A++ L + K + + V+ + V+ EK ++++
Sbjct: 39 FPVKYLGHVEVDESRGMHICEDAVKRLKATGKKA--VKAVLWVSADGLRVVDEKT-KDLI 95
Query: 628 VECRVRFLSFMGVGKDV-HTFAFIMDTG-NQRFECHVFWCEPNAG-NVSEAVQ---AACM 681
V+ + +SF ++ F++I G +R+ CH F + G +S AV AAC+
Sbjct: 96 VDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACL 155
Query: 682 LRYQK 686
R QK
Sbjct: 156 ERKQK 160
Score = 36.2 bits (82), Expect = 0.11
Identities = 32/130 (24%), Positives = 51/130 (39%), Gaps = 19/130 (14%)
Query: 379 PHPDDDDSCSINSDPEAKC-FAVRSLGWVEMAEEDLAPGKSSVAVNNCIRQLSYCKNDIR 437
PH D + + KC F V+ LG VE+ E R + C++ ++
Sbjct: 22 PHQWQTDEEGVRT---GKCSFPVKYLGHVEVDES---------------RGMHICEDAVK 63
Query: 438 DTVGIWGEGKDMYLILENDMLSLVDPMDRSVLHSQPIVSIRVWGVGRDNGRDFAYVARDK 497
+ L + D L +VD + ++ Q I + R+ R F+Y+ RD
Sbjct: 64 RLKATGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDG 123
Query: 498 DTRILKCHVF 507
TR CH F
Sbjct: 124 TTRRWICHCF 133
>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
sapiens]
Length = 304
Score = 40.4 bits (93), Expect = 0.006
Identities = 32/128 (25%), Positives = 61/128 (47%), Gaps = 8/128 (6%)
Query: 568 FHVQYLGMLPVDKPVGMDILNSAIENL-----MTSSNKEDWLSVNMNVADATVTVISEKN 622
++ ++LG V++P G +++ A+ L + S + V + ++ V ++ K
Sbjct: 27 YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKT 86
Query: 623 EEEVLVECRVRFLSFMGVGK-DVHTFAFI-MDTGNQRFECHVFWCEPNAGNVSEAVQAAC 680
+EV C++ +SF K D F FI D+ + + C+VF E A ++ + A
Sbjct: 87 -KEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAF 145
Query: 681 MLRYQKCL 688
L Y+K L
Sbjct: 146 DLAYRKFL 153
>gi|4885433 mitogen-activated protein kinase 8 interacting protein 1
[Homo sapiens]
Length = 711
Score = 40.4 bits (93), Expect = 0.006
Identities = 35/148 (23%), Positives = 72/148 (48%), Gaps = 12/148 (8%)
Query: 562 TELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSS------NKEDWLSVNMNVADATV 615
++ V +F V++LG + V G D+L +A++ + T+ N + ++V +
Sbjct: 561 SDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKI 620
Query: 616 TVISEKNEEEVLVEC----RVRFLSFMGV-GKDVHTFAFI-MDTGNQRFECHVFWCEPNA 669
V ++ ++E +C +++ +SF G K+ F FI + RF CHVF E +
Sbjct: 621 GVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDST 680
Query: 670 GNVSEAVQAACMLRYQKCLVARPPSQKV 697
++E+V A Y++ + P++ +
Sbjct: 681 KALAESVGRAFQQFYKQFVEYTCPTEDI 708
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 40.4 bits (93), Expect = 0.006
Identities = 27/85 (31%), Positives = 35/85 (41%), Gaps = 15/85 (17%)
Query: 237 PKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGW 296
PKT D + + L P W L Q A+ + Q LPPGW
Sbjct: 152 PKTSGSEDDNAEQAEELEPG-----WVVLDQPDAACHLQQQ---------QEPSPLPPGW 197
Query: 297 KRVSDIAG-TYYWHIPTGTTQWERP 320
+ DI G TYY + + TQW+RP
Sbjct: 198 EERQDILGRTYYVNHESRRTQWKRP 222
Score = 33.9 bits (76), Expect = 0.56
Identities = 50/223 (22%), Positives = 79/223 (35%), Gaps = 33/223 (14%)
Query: 181 NHHGTAEEKSQPVQGQASTIIGNGDLLLQKPN----RPQSSPEDGQVATVSSSPE---TK 233
NH + +P T NG++ LQ R Q S E V SS +
Sbjct: 211 NHESRRTQWKRPTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIR 270
Query: 234 KDH-----------PKTGAKTDCALHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWS 282
+D P + D H + L + +SQ ++S +
Sbjct: 271 EDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQ 330
Query: 283 DHSFQTDPDLP----------PGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPADLQGSR 331
++F+ P LP PGW+ D G +YY + TT W +P ++ A ++ S+
Sbjct: 331 AYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKP-TVQATVETSQ 389
Query: 332 -KGSLSSVTPSPTPENEDLHAATVNPDPSLKEF--EGATLRYA 371
S SS P D P + F +G +R+A
Sbjct: 390 LTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPKGWEVRHA 432
>gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens]
Length = 412
Score = 39.7 bits (91), Expect = 0.010
Identities = 36/111 (32%), Positives = 47/111 (42%), Gaps = 24/111 (21%)
Query: 292 LPPGWKRVSDIAGT-YYWHIPTGTTQWERPVS---IPADLQGSRKGSL--------SSVT 339
LPPGW+ G YY + T T WERP S IPA GS + SL +S T
Sbjct: 15 LPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPAS-PGSHRSSLPPTVNGYHASGT 73
Query: 340 PSPTPENEDLHAATVNPD--------PSLKEFEGATLRYASLKLRNAPHPD 382
P+ PE + D PS K+ + T+ ++ PHPD
Sbjct: 74 PAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTI---TINCVTFPHPD 121
>gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens]
Length = 476
Score = 39.7 bits (91), Expect = 0.010
Identities = 36/111 (32%), Positives = 47/111 (42%), Gaps = 24/111 (21%)
Query: 292 LPPGWKRVSDIAGT-YYWHIPTGTTQWERPVS---IPADLQGSRKGSL--------SSVT 339
LPPGW+ G YY + T T WERP S IPA GS + SL +S T
Sbjct: 79 LPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPAS-PGSHRSSLPPTVNGYHASGT 137
Query: 340 PSPTPENEDLHAATVNPD--------PSLKEFEGATLRYASLKLRNAPHPD 382
P+ PE + D PS K+ + T+ ++ PHPD
Sbjct: 138 PAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTI---TINCVTFPHPD 185
>gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens]
Length = 416
Score = 39.7 bits (91), Expect = 0.010
Identities = 36/111 (32%), Positives = 47/111 (42%), Gaps = 24/111 (21%)
Query: 292 LPPGWKRVSDIAGT-YYWHIPTGTTQWERPVS---IPADLQGSRKGSL--------SSVT 339
LPPGW+ G YY + T T WERP S IPA GS + SL +S T
Sbjct: 19 LPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPAS-PGSHRSSLPPTVNGYHASGT 77
Query: 340 PSPTPENEDLHAATVNPD--------PSLKEFEGATLRYASLKLRNAPHPD 382
P+ PE + D PS K+ + T+ ++ PHPD
Sbjct: 78 PAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTI---TINCVTFPHPD 125
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 39.3 bits (90), Expect = 0.013
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 13/140 (9%)
Query: 189 KSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDG--QVATVSSSPETKKDHPKTGAKTDCA 246
+++ V G S + NG +P RP P + A+V+ SP + G+ T
Sbjct: 190 ENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSE--SDGSSTGSL 247
Query: 247 LHRIQNLAPSDEESSWTTLSQDSASPSSPDETDIWSDHSFQTDPDLPPGWKRVSDIAGTY 306
N S+ +S + + S P + T LPPGW++ D G
Sbjct: 248 PPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNP------VTQAPLPPGWEQRVDQHGRV 301
Query: 307 YW--HIPTGTTQWERPVSIP 324
Y+ H+ TT W+RP +P
Sbjct: 302 YYVDHVEKRTT-WDRPEPLP 320
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 3/44 (6%)
Query: 282 SDHSFQTDP--DLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVS 322
+ S + DP LPPGW++ +D G Y+ + T TQWE P S
Sbjct: 387 TSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRS 430
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 57 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 262 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 321
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 322 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 366
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 178 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 363 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 422
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 423 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 467
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 57 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 242 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 301
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 302 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 346
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 57 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 242 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 301
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 302 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 346
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 170 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 355 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 414
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 415 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 459
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 170 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 375 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 434
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 435 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 479
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 178 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 383 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 442
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 443 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 487
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 57 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 262 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 321
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 322 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 366
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 276 DETDIWSDHSFQTDPD-LPPGWK-RVSDIAGTYYWHIPTGTTQWERP 320
D D S H + P LPPGW+ +V ++ TYY + TTQW RP
Sbjct: 57 DSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 6/105 (5%)
Query: 288 TDPDLPPGWKRVSDIAG-TYYWHIPTGTTQWERPVSIPAD--LQGSRKGSLSSVTPSPTP 344
T P LP GW+ D G TYY + TT W RP+ A+ GS S + +
Sbjct: 262 TTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIR 321
Query: 345 ENEDLHAATVNPDPSLKEFEGATLRYA---SLKLRNAPHPDDDDS 386
L + TV L+ + + +R A +L +P P +S
Sbjct: 322 RPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 366
>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
Length = 1573
Score = 38.1 bits (87), Expect = 0.029
Identities = 53/209 (25%), Positives = 79/209 (37%), Gaps = 24/209 (11%)
Query: 186 AEEKSQPVQGQASTIIGNGDLLLQKPNRPQSSPEDGQV--ATVSSSPETKKDHPKTGAKT 243
A + S P AS N DL+L P+ S+P+ V T SP PK
Sbjct: 1044 APDTSPPTPDPASRT--NPDLILTSPDFALSTPDSSVVPALTPEPSPTPLPTLPKELTSD 1101
Query: 244 DCALHRIQNLAPSDEE--SSWTTLSQDSASPS--------SPDETDIWSDHSFQT-DPDL 292
+ +L+P+ E+ S TT D+ S SPD + S H T DP +
Sbjct: 1102 PSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPSP--SPHPTTTPDPTM 1159
Query: 293 PPGWKRVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPENEDLHAA 352
P ++ + T H PT P + P + + T +P P H +
Sbjct: 1160 AP--DPITTLNPTVTPHFPT----TPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITH-S 1212
Query: 353 TVNPDPSLKEFEGATLRYASLKLRNAPHP 381
T+ PDP+ T++ + PHP
Sbjct: 1213 TMIPDPTTTPQPFTTMQPTTTPHSTTPHP 1241
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 37.4 bits (85), Expect = 0.050
Identities = 35/100 (35%), Positives = 43/100 (43%), Gaps = 7/100 (7%)
Query: 289 DPDLPPGWKRVSDIAGT--YYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTPSPTPEN 346
D DLP GW+ +G Y HI T TTQWERP PA S LS TP +
Sbjct: 156 DNDLPDGWEERRTASGRIQYLNHI-TRTTQWERPTR-PASEYSSPGRPLSCFVDENTPIS 213
Query: 347 EDLHAATV--NPDPSLKEFEGATLRYASLKLRNAPHPDDD 384
+ AT + DP L E + R+ + R H D
Sbjct: 214 -GTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPD 252
Score = 33.5 bits (75), Expect = 0.73
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 288 TDPDLPPGWK-RVSDIAGTYYWHIPTGTTQWERPVSIPADLQGSRKGSLSSVTP 340
T PDLP G++ R + Y+ H TG + W P +P DL L + P
Sbjct: 249 TPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDP-RVPRDLSNINCEELGPLPP 301
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,145,955
Number of Sequences: 37866
Number of extensions: 1661449
Number of successful extensions: 5507
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 5248
Number of HSP's gapped (non-prelim): 315
length of query: 736
length of database: 18,247,518
effective HSP length: 110
effective length of query: 626
effective length of database: 14,082,258
effective search space: 8815493508
effective search space used: 8815493508
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.