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Search of human proteins with 50083279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50083279 centrosome protein 4 [Homo sapiens]
(1140 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50083279 centrosome protein 4 [Homo sapiens] 2182 0.0
gi|188528616 testis specific, 10 [Homo sapiens] 500 e-141
gi|13376858 testis specific, 10 [Homo sapiens] 500 e-141
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 188 3e-47
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 171 5e-42
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 159 2e-38
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 159 2e-38
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 155 2e-37
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 154 4e-37
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 154 4e-37
gi|71061468 centromere protein E [Homo sapiens] 154 4e-37
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 151 3e-36
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 151 3e-36
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 151 4e-36
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 151 4e-36
gi|55770834 centromere protein F [Homo sapiens] 150 7e-36
gi|21735548 centrosomal protein 2 [Homo sapiens] 146 1e-34
gi|118498368 kinectin 1 isoform c [Homo sapiens] 145 2e-34
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 145 2e-34
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 144 4e-34
gi|156104908 myosin heavy chain 6 [Homo sapiens] 144 6e-34
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 142 2e-33
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 142 2e-33
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 141 4e-33
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 140 5e-33
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 140 5e-33
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 139 2e-32
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 137 8e-32
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 136 1e-31
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 135 3e-31
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 2182 bits (5655), Expect = 0.0
Identities = 1140/1140 (100%), Positives = 1140/1140 (100%)
Query: 1 MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKE 60
MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKE
Sbjct: 1 MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKE 60
Query: 61 SANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFL 120
SANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFL
Sbjct: 61 SANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFL 120
Query: 121 NNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS 180
NNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS
Sbjct: 121 NNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS 180
Query: 181 EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELRERE 240
EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELRERE
Sbjct: 181 EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELRERE 240
Query: 241 IERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKET 300
IERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKET
Sbjct: 241 IERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKET 300
Query: 301 VTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD 360
VTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD
Sbjct: 301 VTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD 360
Query: 361 LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQL 420
LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQL
Sbjct: 361 LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQL 420
Query: 421 TLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAR 480
TLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAR
Sbjct: 421 TLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAR 480
Query: 481 EKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY 540
EKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY
Sbjct: 481 EKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLY 540
Query: 541 NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSL 600
NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSL
Sbjct: 541 NEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSL 600
Query: 601 FGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSS 660
FGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSS
Sbjct: 601 FGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSS 660
Query: 661 HQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDE 720
HQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDE
Sbjct: 661 HQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDE 720
Query: 721 EAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQ 780
EAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQ
Sbjct: 721 EAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQ 780
Query: 781 LKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLE 840
LKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLE
Sbjct: 781 LKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLE 840
Query: 841 LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQA 900
LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQA
Sbjct: 841 LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQA 900
Query: 901 EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEEL 960
EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEEL
Sbjct: 901 EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEEL 960
Query: 961 RHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLK 1020
RHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLK
Sbjct: 961 RHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLK 1020
Query: 1021 KQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENT 1080
KQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENT
Sbjct: 1021 KQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENT 1080
Query: 1081 MLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPPLSSTLRSPSHSPEHRNV 1140
MLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPPLSSTLRSPSHSPEHRNV
Sbjct: 1081 MLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPPLSSTLRSPSHSPEHRNV 1140
>gi|188528616 testis specific, 10 [Homo sapiens]
Length = 698
Score = 500 bits (1288), Expect = e-141
Identities = 265/671 (39%), Positives = 441/671 (65%), Gaps = 13/671 (1%)
Query: 479 AREKSSIFRTPEKGDYNSEIHQI---TRERDELQRMLERFEKYMEDIQSNVKLLTAERDK 535
+R KS +P N ++ + TR+R+EL+ MLE++E+++ +IQ NVK+L +ERDK
Sbjct: 4 SRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDK 63
Query: 536 LSVLYNEAQEELSALRKE------STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALR 589
+ +LY +AQEE++ LR+E S ++T H I+ +E E+++A +DLRR+ E+++LR
Sbjct: 64 IFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLR 123
Query: 590 EKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQA 649
E+L+ +E + K+ LE+ IE L C H L+ E+ E S + +MKETI ++E ++K A
Sbjct: 124 ERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA 183
Query: 650 QKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKID 709
+K + QK E NSLR++ E ++ + D Q L+ K+ EL+ Q +I L+EKID
Sbjct: 184 RKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKID 243
Query: 710 ELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKI 769
+ +Q EE ++ T+ + KEK+ LQ +D+K+E IA+L E+LA KEK ++ MK
Sbjct: 244 NFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKN 303
Query: 770 MISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLAT 829
+I+E E + Q E L+ +++++ +RRQLD + EL ++ R R+I +N LQ+ A
Sbjct: 304 IIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAK 363
Query: 830 MARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNR 889
+ENQ +S +L E ++K +V EV++ ++++ ++E EN+ ++++ + +
Sbjct: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
Query: 890 AEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSM 949
AE+WE KA Q+E ++++++LEL++ + E L+E+V+ L +E+++H+NA +Y+SQIS++
Sbjct: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
Query: 950 AKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL 1009
K++ ++EEEL+ + EK + L DLSS RELCIKLDS K+++ +QL +K+ E E EL
Sbjct: 484 HKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENEL 543
Query: 1010 ENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSE 1069
++ SE +LL+ Q++NER +++NLE+LL NRDKE+ S + EK++EIQLLKE L L+E
Sbjct: 544 DSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAE 603
Query: 1070 SKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPP--LSST 1127
+K+ QSR+ R V QL+ D D KRQ+ TER+ERERA+QE+RR ++ +SST
Sbjct: 604 NKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSST 663
Query: 1128 LR--SPSHSPE 1136
++ + HSPE
Sbjct: 664 MKPNTKCHSPE 674
Score = 81.6 bits (200), Expect = 4e-15
Identities = 123/573 (21%), Positives = 253/573 (44%), Gaps = 84/573 (14%)
Query: 291 IRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKE 350
+R + ++ +++ ++ + + L + L + A + H E+ +E + + E
Sbjct: 98 LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDE 157
Query: 351 IKRKLSEMQDLEETMAKLQLEL-NLCQKEKE---------------RLSDELLVKSDLET 394
++S M ++ET++ ++ E+ +L +K + RL E K +T
Sbjct: 158 RMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDT 217
Query: 395 VVH--------QLEQEK-QRLSKKVESFAVTERQLTLEVERMRLEHG-----IKRRDRSP 440
H QL QEK L +K+++F RQ + E + + G K ++
Sbjct: 218 QRHLAKKKYELQLTQEKIMCLDEKIDNFT---RQNIAQREEISILGGTLNDLAKEKECLQ 274
Query: 441 SRLDTFLKGIE---EERDYYKKELERLQHIIQR-----RSCSTSYSAREKSSIFRTPEKG 492
+ LD + I E +K + +++II R C+ + E+ +
Sbjct: 275 ACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLD 334
Query: 493 DYNSEIHQITRERDEL----QRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS 548
+ N E+ QI RERD L + E+F K ++ Q+ K KL+ +NE +
Sbjct: 335 ETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSK-------KLNDTHNELNDIKQ 387
Query: 549 ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVS-------LF 601
++ + + NI+ E E + LR+ + E K E + +
Sbjct: 388 KVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
Query: 602 GKSELEKTIEHLTCVNHQLE---SEKYELKSKVLIMKETIESLENKL-KVQAQKFSHVAG 657
++E + E + +N ++E + + KS++ + +++ +E +L KVQ +K S +A
Sbjct: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD 507
Query: 658 DSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTS 717
SS ++ + L E L R + + ++ EL+SA ++I++L ++ N +++
Sbjct: 508 LSSTRELCI-KLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQM--ANERISM 564
Query: 718 QDEEAHVMKKTIGVIDKEKDF-LQETVDEKTEKIANLQENL-------ANKEKAVAQMKI 769
Q+ EA + V +++K++ Q + EK +I L+E+L A + + VAQ +
Sbjct: 565 QNLEA------LLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRN 618
Query: 770 MISECESSVNQLKETL----VNRDREINSLRRQ 798
++++ E+ ++ K L R+R + LRRQ
Sbjct: 619 VVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
Score = 70.5 bits (171), Expect = 9e-12
Identities = 122/660 (18%), Positives = 276/660 (41%), Gaps = 90/660 (13%)
Query: 88 ELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQE 147
EL + E ++H+ E++ ++K E + L Q ++ L +E + + +
Sbjct: 35 ELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM---KSCKSPKS 91
Query: 148 KNLHAVVQTPGGKKRSIAFR------------RQRMQIDEPVPPSEVSSYPVPQPDDPYI 195
HA+++ +R +AF R+R++I + +E +
Sbjct: 92 TTAHAILRRVE-TERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHL---------- 140
Query: 196 ADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPD 255
+ RI+EL+ VH L ++ S + + I E+E++ L+ ++ D
Sbjct: 141 -------EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA-----RKAMD 188
Query: 256 VLSLESRNK--TNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETV---TSEVVNLSN 310
S R K N + + N + D L + L K+ EL T+E + ++ N +
Sbjct: 189 TESELGRQKAENNSLRLLYENTEKD-LSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTR 247
Query: 311 KNEKLCQELTEIDQLAQQLERHKEEVLETADKE------LGEAKKEIKRKLSEMQ----D 360
+N +E++ + L + KE + DK+ LGE+ ++ +S M+ +
Sbjct: 248 QNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAE 307
Query: 361 LEETMAKLQLELNLCQKEKERL-------SDELL-VKSDLETVVHQLEQEKQRLSK-KVE 411
+E+ + L +C+++ R+ +DEL + + + + H + +++ +K K E
Sbjct: 308 MEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQE 367
Query: 412 SFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQR- 470
+ A++++ E ++ ++ + ++L LK E E ++L + +
Sbjct: 368 NQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENW 427
Query: 471 ----RSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNV 526
R + + I E ++ + RE ++ ++ + + +V
Sbjct: 428 ENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSV 487
Query: 527 KLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVS--LMEKEKELAL--SDLRRIM 582
+ E K+ A +LS+ R+ + + +++ L+ K++E+ + ++L
Sbjct: 488 VKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAH 547
Query: 583 AEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLE 642
+E E LR ++ + E +S+ LE + +Q + E +S++ ++KE + E
Sbjct: 548 SEIELLRSQMAN-ERISM---QNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAE 603
Query: 643 NKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIK 702
NK+ +Q++ +V R V QL+ +D + +L +R E E A +++
Sbjct: 604 NKMAIQSR--------------DVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELR 649
>gi|13376858 testis specific, 10 [Homo sapiens]
Length = 698
Score = 500 bits (1288), Expect = e-141
Identities = 265/671 (39%), Positives = 441/671 (65%), Gaps = 13/671 (1%)
Query: 479 AREKSSIFRTPEKGDYNSEIHQI---TRERDELQRMLERFEKYMEDIQSNVKLLTAERDK 535
+R KS +P N ++ + TR+R+EL+ MLE++E+++ +IQ NVK+L +ERDK
Sbjct: 4 SRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDK 63
Query: 536 LSVLYNEAQEELSALRKE------STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALR 589
+ +LY +AQEE++ LR+E S ++T H I+ +E E+++A +DLRR+ E+++LR
Sbjct: 64 IFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLR 123
Query: 590 EKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQA 649
E+L+ +E + K+ LE+ IE L C H L+ E+ E S + +MKETI ++E ++K A
Sbjct: 124 ERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA 183
Query: 650 QKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKID 709
+K + QK E NSLR++ E ++ + D Q L+ K+ EL+ Q +I L+EKID
Sbjct: 184 RKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKID 243
Query: 710 ELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKI 769
+ +Q EE ++ T+ + KEK+ LQ +D+K+E IA+L E+LA KEK ++ MK
Sbjct: 244 NFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKN 303
Query: 770 MISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLAT 829
+I+E E + Q E L+ +++++ +RRQLD + EL ++ R R+I +N LQ+ A
Sbjct: 304 IIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAK 363
Query: 830 MARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNR 889
+ENQ +S +L E ++K +V EV++ ++++ ++E EN+ ++++ + +
Sbjct: 364 AKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANED 423
Query: 890 AEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSM 949
AE+WE KA Q+E ++++++LEL++ + E L+E+V+ L +E+++H+NA +Y+SQIS++
Sbjct: 424 AENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTL 483
Query: 950 AKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL 1009
K++ ++EEEL+ + EK + L DLSS RELCIKLDS K+++ +QL +K+ E E EL
Sbjct: 484 HKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENEL 543
Query: 1010 ENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSE 1069
++ SE +LL+ Q++NER +++NLE+LL NRDKE+ S + EK++EIQLLKE L L+E
Sbjct: 544 DSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAE 603
Query: 1070 SKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPP--LSST 1127
+K+ QSR+ R V QL+ D D KRQ+ TER+ERERA+QE+RR ++ +SST
Sbjct: 604 NKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSST 663
Query: 1128 LR--SPSHSPE 1136
++ + HSPE
Sbjct: 664 MKPNTKCHSPE 674
Score = 81.6 bits (200), Expect = 4e-15
Identities = 123/573 (21%), Positives = 253/573 (44%), Gaps = 84/573 (14%)
Query: 291 IRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKE 350
+R + ++ +++ ++ + + L + L + A + H E+ +E + + E
Sbjct: 98 LRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDE 157
Query: 351 IKRKLSEMQDLEETMAKLQLEL-NLCQKEKE---------------RLSDELLVKSDLET 394
++S M ++ET++ ++ E+ +L +K + RL E K +T
Sbjct: 158 RMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDT 217
Query: 395 VVH--------QLEQEK-QRLSKKVESFAVTERQLTLEVERMRLEHG-----IKRRDRSP 440
H QL QEK L +K+++F RQ + E + + G K ++
Sbjct: 218 QRHLAKKKYELQLTQEKIMCLDEKIDNFT---RQNIAQREEISILGGTLNDLAKEKECLQ 274
Query: 441 SRLDTFLKGIE---EERDYYKKELERLQHIIQR-----RSCSTSYSAREKSSIFRTPEKG 492
+ LD + I E +K + +++II R C+ + E+ +
Sbjct: 275 ACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLD 334
Query: 493 DYNSEIHQITRERDEL----QRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS 548
+ N E+ QI RERD L + E+F K ++ Q+ K KL+ +NE +
Sbjct: 335 ETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSK-------KLNDTHNELNDIKQ 387
Query: 549 ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVS-------LF 601
++ + + NI+ E E + LR+ + E K E + +
Sbjct: 388 KVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELIT 447
Query: 602 GKSELEKTIEHLTCVNHQLE---SEKYELKSKVLIMKETIESLENKL-KVQAQKFSHVAG 657
++E + E + +N ++E + + KS++ + +++ +E +L KVQ +K S +A
Sbjct: 448 AEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALAD 507
Query: 658 DSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTS 717
SS ++ + L E L R + + ++ EL+SA ++I++L ++ N +++
Sbjct: 508 LSSTRELCI-KLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQM--ANERISM 564
Query: 718 QDEEAHVMKKTIGVIDKEKDF-LQETVDEKTEKIANLQENL-------ANKEKAVAQMKI 769
Q+ EA + V +++K++ Q + EK +I L+E+L A + + VAQ +
Sbjct: 565 QNLEA------LLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRN 618
Query: 770 MISECESSVNQLKETL----VNRDREINSLRRQ 798
++++ E+ ++ K L R+R + LRRQ
Sbjct: 619 VVTQLEADLDITKRQLGTERFERERAVQELRRQ 651
Score = 70.5 bits (171), Expect = 9e-12
Identities = 122/660 (18%), Positives = 276/660 (41%), Gaps = 90/660 (13%)
Query: 88 ELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQE 147
EL + E ++H+ E++ ++K E + L Q ++ L +E + + +
Sbjct: 35 ELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMM---KSCKSPKS 91
Query: 148 KNLHAVVQTPGGKKRSIAFR------------RQRMQIDEPVPPSEVSSYPVPQPDDPYI 195
HA+++ +R +AF R+R++I + +E +
Sbjct: 92 TTAHAILRRVE-TERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHL---------- 140
Query: 196 ADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPD 255
+ RI+EL+ VH L ++ S + + I E+E++ L+ ++ D
Sbjct: 141 -------EQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLA-----RKAMD 188
Query: 256 VLSLESRNK--TNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETV---TSEVVNLSN 310
S R K N + + N + D L + L K+ EL T+E + ++ N +
Sbjct: 189 TESELGRQKAENNSLRLLYENTEKD-LSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTR 247
Query: 311 KNEKLCQELTEIDQLAQQLERHKEEVLETADKE------LGEAKKEIKRKLSEMQ----D 360
+N +E++ + L + KE + DK+ LGE+ ++ +S M+ +
Sbjct: 248 QNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAE 307
Query: 361 LEETMAKLQLELNLCQKEKERL-------SDELL-VKSDLETVVHQLEQEKQRLSK-KVE 411
+E+ + L +C+++ R+ +DEL + + + + H + +++ +K K E
Sbjct: 308 MEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQE 367
Query: 412 SFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQR- 470
+ A++++ E ++ ++ + ++L LK E E ++L + +
Sbjct: 368 NQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENW 427
Query: 471 ----RSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNV 526
R + + I E ++ + RE ++ ++ + + +V
Sbjct: 428 ENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSV 487
Query: 527 KLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVS--LMEKEKELAL--SDLRRIM 582
+ E K+ A +LS+ R+ + + +++ L+ K++E+ + ++L
Sbjct: 488 VKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAH 547
Query: 583 AEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLE 642
+E E LR ++ + E +S+ LE + +Q + E +S++ ++KE + E
Sbjct: 548 SEIELLRSQMAN-ERISM---QNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAE 603
Query: 643 NKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIK 702
NK+ +Q++ +V R V QL+ +D + +L +R E E A +++
Sbjct: 604 NKMAIQSR--------------DVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELR 649
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 188 bits (477), Expect = 3e-47
Identities = 229/1105 (20%), Positives = 491/1105 (44%), Gaps = 84/1105 (7%)
Query: 56 KAEKESANFDFVLEPYKLENARLSRENNEL---YLELMKLREHSDQHVKELKTSLKKCAR 112
+A+ E+ N + + ++ + A+L+ E ++ Y E LRE ++Q V L L K A
Sbjct: 146 EAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 113 ETADLK--FLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQR 170
DLK L + +L+KE ++Q L + N+ + K + + Q
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELV----QVQTLMD-NMTLERERESEKLKDECKKLQS 260
Query: 171 MQIDEPVPPSEVSSYPVPQPDDPYI-ADLLQVADNRIQELQQEVHQLQEKLAMMESGVRD 229
S++ S P + + LQ + + EL Q+ L E L E +D
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE---QD 317
Query: 230 YSKQIELRERE-IERLSV-ALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDL 287
Y+K E E + + ++ A + D L+SR +E + +++++ +A + L
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 288 EKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEA 347
++ + E+ + + +E L + E+ Q ++ QL ++LET +++LGEA
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH---SKLLET-ERQLGEA 433
Query: 348 KKEIK--RKLS--EMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEK 403
+K R+LS ++ D E+ +A LQL+L+ + +E+L +++ ++L+ + + +Q+
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLS---RLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 404 QRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELER 463
Q +S R+ ++E++ + G K D+ L+ L+ +E +KE E
Sbjct: 491 QEQQALQQSTTAKLREAQNDLEQVLRQIGDK--DQKIQNLEALLQKSKENISLLEKERED 548
Query: 464 LQHIIQRRSCSTSY--SAREKS-----SIFRTPEKGDYNSEIHQITRERDELQRMLERFE 516
L IQ T+ +EK+ + + EK SE H+ +E L ++ +
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN--LHDQVQEQK 606
Query: 517 KYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALS 576
++ Q V L ++L+ NE++E++S L Q A ++ E K +
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL---DIQIKAKTELLLSAEAAKTAQRA 663
Query: 577 DLRRIM-AEKEALREKLEHIEEVSLF---GKSELEKTIEHLTCVNHQLESEKYELKSKVL 632
DL+ + + AL++K + + +++ ++L+ EH + QLES E K K L
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS----QLESHLKEYKEKYL 719
Query: 633 IMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRG 692
+++ E LE ++K V ++ R +N L+ + +L +++
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
Query: 693 ELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTE-KIA 751
+ S + ++ E ++ + K+T Q+EE ++K+ + +E E ++ + + +
Sbjct: 780 IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 752 NLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGR 811
LQ+ KE + + +S + ++++ ++L N E ++ AA +L++ +
Sbjct: 840 ELQKVKMEKEALMTE----LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 812 SREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAA 871
+ +LQ + +E +E+ LE + ++K ++ ++ + ++ +
Sbjct: 896 ELK------HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ 949
Query: 872 KEKENQDLLDRFQMLHNRAEDWEVKAHQAEGE-----------SSSVRLELLSIDTERRH 920
EKE Q L L +E + + +GE + ++ +L E
Sbjct: 950 NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAA 1009
Query: 921 LRERVELLEKEIQEHINA-------HHAYESQISSMAKAMSRLEEELRHQEDEKATVLND 973
+E++ +L+ ++ + ES++ + + + +EE+L +++ + N
Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069
Query: 974 LSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNL 1033
+ + +L +L + K + Q K + + L++++ E L +K+L NE+ + +
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
Query: 1034 ESLLATNRDK--EFHSHLTSHEKDT--EIQLLKE-KLTLSESKLTSQSRENTMLRAKVAQ 1088
E + + + + L SH+ ++ EI LK+ K L + KL Q + ++ L+A V Q
Sbjct: 1130 EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADS-LKAAVEQ 1188
Query: 1089 LQTDYDALKRQISTERYERERAIQE 1113
+ + LK Q+ E E ++ E
Sbjct: 1189 EKRNQQILKDQVKKEEEELKKEFIE 1213
Score = 141 bits (355), Expect = 4e-33
Identities = 236/1205 (19%), Positives = 483/1205 (40%), Gaps = 157/1205 (13%)
Query: 5 VERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKA-EKESAN 63
++ KY R + + T E L + DL TE L++ + V +KE
Sbjct: 175 IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL--KTELLQRPGIEDVAVLKKELVQ 232
Query: 64 FDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETA-------D 116
+++ LE R S + + +L S+ + +L++ L K +E A
Sbjct: 233 VQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292
Query: 117 LKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQR----MQ 172
LK N+ K + L + K + +L+EK+ V KK A Q+ Q
Sbjct: 293 LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS----KKNIQATLHQKDLDCQQ 348
Query: 173 IDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSK 232
+ + SE S + + L Q+L++E+ +++ K +++ + +
Sbjct: 349 LQSRLSASETSLHRIHVE--------LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 233 QIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIR 292
Q E +E+ +L ++ L S+ E+ + + ++ +Q + +
Sbjct: 401 QREEKEQHGLQLQ--------SEINQLHSKLLETERQLGEAHGRLKEQRQLSSE------ 446
Query: 293 ELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEE-------------VLET 339
+LM+ ++ V + LS E+L +++T +L QL++ K++ L
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 340 ADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL-------SDELLVKSDL 392
A +L + ++I K ++Q+LE + K + ++L +KE+E L E V + L
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566
Query: 393 ETVVHQLEQEKQRLSKKVESF-----------------------AVTERQLTLEVERMRL 429
+ H L+++ +L++K+++ A +R L+LE L
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 430 EHGIKRRDRSPSRLDTFLKGIEE-----------ERDYYKKELERLQHIIQRRSCSTSYS 478
+ S+LD +K E +R + L+ Q+ +Q + +
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 479 AREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSV 538
+ + T + D Q+ E + E+ E+++ +K L A+ ++
Sbjct: 687 TTQLDQV--TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 539 LYNEAQEELSALRKESTQTTAPHNIVSL-MEKEKELALS---DLRRIMAEKEALREKLEH 594
+A ++L R+ +T +S +E EKE+ S DL++ E++++KL
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 595 IEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSH 654
EE K + E + + +L + +++ +K E+L +L K S
Sbjct: 805 QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864
Query: 655 VAGDSSHQKTEVNSLRIVNE----QLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDE 710
V+ + K+E + L+++ + +H+L ++ Q ++K EK E
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 711 ----LNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDE--------------------- 745
L L++ S E+ + T+ +KE+ LQ ++E
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 746 ----KTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDA 801
KTE LQ+ L + +A K IS +++ + +ET + +L A
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 802 AHKELDEVGRSREIAFKE---NRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKY 858
++L V +A ++ NR + + +E + LE +KE+ K
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
Query: 859 ITEVSRWESLMAAKEKENQDLLDRFQMLHNRAE------DWEVKAHQAEGESSSVRLELL 912
+ ++ + +SL + + L + + R E + E+K+H+ E L+
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK-- 1162
Query: 913 SIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK-AMSRLEEELRHQEDEKATVL 971
D ++ +++++EL K + + A E + + K + + EEEL+ + EK L
Sbjct: 1163 --DAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Query: 972 NDLSSLRELCIKLDSGKDI-MTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTV 1030
+ +E+ +K + +T Q+ + N V E ++ + L+KQ + R +
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278
Query: 1031 KNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQS-------RENTMLR 1083
LE+ + N+D+ + + EI+ L+ K+ + KL + + REN L+
Sbjct: 1279 AVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Query: 1084 AKVAQ 1088
K Q
Sbjct: 1339 IKHTQ 1343
Score = 133 bits (335), Expect = 8e-31
Identities = 211/1028 (20%), Positives = 460/1028 (44%), Gaps = 125/1028 (12%)
Query: 5 VERKYINIRKRLDQLGY----RQTLTVECLPLVEKLFSDLVHTTESL--------RQSKL 52
VE KY +++ QL ++ ++ + +L S L+ T L Q +L
Sbjct: 384 VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL 443
Query: 53 SAVKA-EKESANFDFVLEPYKLENARLSRENN--ELYLELMKLRE-HSDQH--------- 99
S+ K +KE D L+ +LE + N EL +L K ++ H +Q
Sbjct: 444 SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 100 VKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGG 159
++E + L++ R+ D +Q L+ L ++SK +N + + + ++L+A +Q G
Sbjct: 504 LREAQNDLEQVLRQIGD----KDQKIQNLEALLQKSK-ENISLLEKEREDLYAKIQAGEG 558
Query: 160 K--------KRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQ 211
+ +++ + Q Q+ E + ++ S+ Q + +++QE +
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLK-NQSESHKQAQEN----------LHDQVQEQKA 607
Query: 212 EVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIA 271
+ Q+++ +E+ V + + Q+ + ++ +L + + ++ +LS E+ KT ++ A
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA-KTELLLSAEAA-KTAQR--A 663
Query: 272 HLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLER 331
L +D Q A +D ++ + ++ + VT+++ + +L L E + LE+
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723
Query: 332 HKEEVLETADKELGEAKKEIKR-KLSEMQDLEET-MAKLQLELNLCQKEKERLSDELLVK 389
EE LE K+L E+K K +QDL++ LEL + K+ ++ +V
Sbjct: 724 KTEE-LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 390 S---DLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTF 446
S DL+ LE KQ+L+K+ E + ++ + +++H + + T
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH--EELNNRIQTTVTE 840
Query: 447 LKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERD 506
L+ ++ E++ EL ++ + + S S S KS + +KG + I + +
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNS---KSEFEKENQKG--KAAILDLEKTCK 895
Query: 507 ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSL 566
EL+ L+ ME+ K L +K ++ + EL++++++ Q N +
Sbjct: 896 ELKHQLQ---VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA---QNTLKQ 949
Query: 567 MEKEKELALSDLRRIMAEKEALREKLEHIE---EVSLFGKSELEKTIEHLTCVNHQLESE 623
EKE++ ++ + E ++++E ++ ++++ K+ELE ++ QL
Sbjct: 950 NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ------QLTQA 1003
Query: 624 KYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDY 683
EL ++ KE I L+N + + F + D +++E+ + R + +
Sbjct: 1004 AQELAAE----KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR-------QDLKSV 1052
Query: 684 QHRLSIKRGELESAQAQI----KILEE-KIDELNLKMTSQDEEAHVMK--KTIGVIDKEK 736
+ +LS+ + +L S + QI K+++E K + L+ S +E + + K + I KEK
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 737 DFLQETVDEKTEKIANLQENLANKEKAVAQM--KIMISECES-----SVNQLKETLVNRD 789
++ + + K+A ++E +EK + ++ ++ + ES ++ K+ L+ +
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 790 REINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATM-----ARENQEISLELEAA 844
E+ L AA +++ R+++I + ++ +++L A+ + EI E E
Sbjct: 1173 LELQGKADSLKAA---VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIK-EKEVG 1228
Query: 845 VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904
+++ EE ++++ IT ++ E+L K++ +Q R + E + GE
Sbjct: 1229 MKKHEENEAKLTMQITALN--ENLGTVKKE--------WQSSQRRVSELEKQTDDLRGEI 1278
Query: 905 SSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQE 964
+ + + + ERR L ER E EI++ + ++ + A+ L E + +
Sbjct: 1279 AVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Query: 965 DEKATVLN 972
+ LN
Sbjct: 1339 IKHTQALN 1346
Score = 95.5 bits (236), Expect = 3e-19
Identities = 122/625 (19%), Positives = 277/625 (44%), Gaps = 54/625 (8%)
Query: 529 LTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRR------IM 582
L +RD +++L E Q+ ++L++E + + +EK + L + +
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYS---EELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 583 AEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLE 642
AE ++L ++LE + + F +++ E QL +E ++KSK + E+ E
Sbjct: 135 AELQSLEQQLEEAQTEN-FNIKQMKDLFEQKAA---QLATEIADIKSKYDEERSLREAAE 190
Query: 643 NKLKVQAQKFSHVAGDSSHQKTE------VNSLRIVNEQLQRSVDDYQHRLSIKRG-ELE 695
K+ ++ + A KTE + + ++ ++L + V ++++R E E
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ-VQTLMDNMTLERERESE 249
Query: 696 SAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQE 755
+ + K L+ + ++ E + + V +E L+ +V+E T+K L E
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 756 NLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREI 815
NL KE+ +++ +E S ++ TL +D + L+ +L A+ L +
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369
Query: 816 AFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKE 875
+ ++L+++L+ + + Q + E + Q++EE + + +E+++ S + E++
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 876 NQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERV-------ELL 928
+ R + + + K E + + ++L+L ++ + L+E+V L
Sbjct: 430 LGEAHGRLKEQRQLSSE---KLMDKEQQVADLQLKLSRLEEQ---LKEKVTNSTELQHQL 483
Query: 929 EKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLN----------DLSSLR 978
+K Q+H +S + + +A + LE+ LR D+ + N ++S L
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE 543
Query: 979 E------LCIKLDSGKDIMTQQLNSKNLEFERVVVEL-ENVKSESDLLKKQLSNERHTVK 1031
+ I+ G+ + QL KN + V +L E +K++S+ K+ N V+
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 1032 NLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQT 1091
++ L +D+ + +E ++++ KEK +S+ + +++ +L A+ A+
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEK--VSQLDIQIKAKTELLLSAEAAKTAQ 661
Query: 1092 DYDALKRQISTERYERERAIQEMRR 1116
D L+ + T + + QE+ +
Sbjct: 662 RAD-LQNHLDTAQNALQDKQQELNK 685
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 171 bits (432), Expect = 5e-42
Identities = 245/1159 (21%), Positives = 505/1159 (43%), Gaps = 144/1159 (12%)
Query: 45 ESLRQSKLSAV--KAEKESANFDF--VLEPYKLENARLSRENNELYLELMKLREHSDQHV 100
E+ QSK AV +AEK N + ++E +K E L + + L+ E KL+ Q+
Sbjct: 582 ENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE--KLQVLKQQYQ 639
Query: 101 KELKTSLKKCARET------------ADLKFLNNQYAHKLKLLEKESKAKNERIQQLQ-- 146
E++ +KC +E A ++ +N + KL + + E ++ + + ++
Sbjct: 640 TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699
Query: 147 ----EKNLHAVVQTPGGKKRSIAFR------RQRMQIDEPVPPSEVSSYPVPQPDDPYIA 196
E+ L + K+ + + + Q+D + EVS I
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS-----------IQ 748
Query: 197 DLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDV 256
+ ++I +L+ + + + L ++ V + I+ E E+++ S LD +S
Sbjct: 749 RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQS 808
Query: 257 LSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEV----VNLSNKN 312
+ E + K E+ +A L ++ L+ L K++ E+ K+ V +E+ + + +
Sbjct: 809 ATHE-QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 313 EKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLEL 372
++L ++ +E++Q + L + E LE +KE + K+ + K + + + E K ++E+
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKK-EIEI 926
Query: 373 NLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT--------ERQLTLEV 424
L QK + ++ + ET E++ +++ +K + T E +L E+
Sbjct: 927 -LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 425 ERMRLEHGIKRRDRSPSRLDT-------FLKGIEEERDYYKKELERLQHIIQRRSCSTSY 477
E LE K + + L+ + K+++E L + RR +
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV-HRRELNDVI 1044
Query: 478 SAREKSSIFRTPEKGDYNSEIHQIT-----RERDELQRMLERFEKYMEDIQSNVKLLTAE 532
S EK + ++ + EIH+I +E EL++ + F E++ + L E
Sbjct: 1045 SIWEK----KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEE 1100
Query: 533 RDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKL 592
K NE QE+L +++S + + ++ E DL + + E L+E+L
Sbjct: 1101 GVKQDTTLNELQEQL---KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 593 EHIEEVSLFGK-------SELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL 645
++ ++ K S+L+ T E + E L+ K L K+ E L +L
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1217
Query: 646 KVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHR-------LSIKRGELESAQ 698
+ +K + +++ ++S + N L R + QHR L IK + +
Sbjct: 1218 DICCKKTEALLEAKTNELINISSSK-TNAILSR-ISHCQHRTTKVKEALLIKTCTVSELE 1275
Query: 699 AQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKT---EKIANLQE 755
AQ++ L E+ + LN+ S + H +++ I K ++ V EK ++ N Q+
Sbjct: 1276 AQLRQLTEEQNTLNI---SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332
Query: 756 NLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKEL-DEVGRSRE 814
+ KE + Q+K +SE ++V +KE L + EI+SL +QL + +L + + S +
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Query: 815 IAFKENRRLQ--DDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAK 872
A + R Q ++ + + Q++S +++ +EK +V + + S W+ ++
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
Query: 873 EKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEI 932
++Q+ + Q+ E+K+ +A + + L +D + + R + L+ E+
Sbjct: 1453 FTQHQNTVKELQI------QLELKSKEAYEKDEQINLLKEELDQQNK----RFDCLKGEM 1502
Query: 933 QEHINAHHAYESQISSMAKAMSRLEEELRHQ-------EDEKATVLNDLSSLRELCIKLD 985
E S M K S LE EL+ Q ED ++ SL E+ +
Sbjct: 1503 ----------EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN 1552
Query: 986 SGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEF 1045
KDI ++L K F+ + E +N E++ L N+ V ++++ L T + +
Sbjct: 1553 QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ---VYSMKAELETKKKELE 1609
Query: 1046 HSHLTSHEKDTEIQLLKEKL------TLSESKLTSQSRENTMLRAKVAQLQTDYDALKR- 1098
H +L+ K+ E++ L+++L L+E K ++ + + + ++Q++ + K+
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 1099 ------QISTERYERERAI 1111
+++T+ ERER +
Sbjct: 1670 TESHLSELNTKLQEREREV 1688
Score = 145 bits (366), Expect = 2e-34
Identities = 265/1177 (22%), Positives = 490/1177 (41%), Gaps = 175/1177 (14%)
Query: 39 DLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQ 98
DLV ++SL + +L E + L Y+ + + L L E KL+ Q
Sbjct: 126 DLVGNSDSLNKEQLIQRLRRMERS-----LSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
Query: 99 HVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLH-AVVQTP 157
S K R A+L+ K L++E A L+EK+ + +V+QT
Sbjct: 181 -------SQDKSLRRIAELREELQMDQQAKKHLQEEFDAS------LEEKDQYISVLQTQ 227
Query: 158 GGKKRSIAFRRQRMQID--EPVPPSEVSSYPVPQPDDPYIADLLQVADNR----IQELQQ 211
+ R M +D +P+P E + + ++P V D ++ LQQ
Sbjct: 228 VSLLKQ-RLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQ 286
Query: 212 EVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSP--DVLSLESRNKTNEKL 269
V + + L + ++ + +Q L E E L LD + L KT KL
Sbjct: 287 RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKT--KL 344
Query: 270 IAHLNIQVDFLQQANKD----LEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQL 325
I L + ++Q +D + + R++ ET E E+ L ++ + Q T+ ++L
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR---IKQMTTQGEEL 401
Query: 326 AQQLERHKEEVLETADKELGEAKK--EIKRKL-SEMQDLEETMAKLQLELNLC-QKEKER 381
+Q E+ + E +K L A+K E +RKL +EM + +T+ K E + Q+E R
Sbjct: 402 REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSR 461
Query: 382 LSDEL---LVKSDLETVVH-------QLEQEKQRLSKKVESFAVT-ERQLTLEVERMRLE 430
+ E+ + KS E + +L +++Q L+KK+++ + Q+ + +E+ + E
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSE 521
Query: 431 H-GIKRRDRSPSRL----------------DTFLKGIEEERDYYKKELERLQHIIQRRSC 473
+ I + L + L+ +++E + Y+ + L+ ++ +S
Sbjct: 522 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE-KSL 580
Query: 474 STSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAER 533
+ + + ++ EK +N EI M+E+ + +E ++ L E
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEI----------TVMVEKHKTELESLKHQQDALWTE- 629
Query: 534 DKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRI-MAEKEALREKL 592
KL VL + Q E+ LR++ E+EKE L D I A E + EK
Sbjct: 630 -KLQVLKQQYQTEMEKLREK-------------CEQEKETLLKDKEIIFQAHIEEMNEKT 675
Query: 593 EHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESL--ENKLKVQAQ 650
+V L + + H+LE E LK + MK+ +E+ E K Q Q
Sbjct: 676 LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQ 735
Query: 651 KFSHV-AGDSSHQKTE------VNSLRIVNEQLQRSVDDYQHRL-----SIKR--GELES 696
S + + S Q+TE +N L ++ ++ + + ++Q + IKR GEL+
Sbjct: 736 VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQ 795
Query: 697 AQA--------------QIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEK------ 736
A A Q K EE++ +L K+ + E ++ K + ++ +K
Sbjct: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 737 ---------DFLQETVDEKTE---KIANL----QENLANKEKAVAQMKIMISECESSVNQ 780
D +Q+ + +E K+ +L + L + K Q K ++ E E+ + Q
Sbjct: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 781 LKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLE 840
++E + +EI L ++L A + + E FK + + + A+E QE +L+
Sbjct: 916 MRE---GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE-TLK 971
Query: 841 LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKE-NQDLLDRFQMLHNRAEDWEVKAHQ 899
+ QE ++K + E+S+ KEK+ N +L+ Q D +
Sbjct: 972 KKLLDQE-AKLKKELENTALELSQ-------KEKQFNAKMLEMAQANSAGISDAVSRLET 1023
Query: 900 AEGESSSVRLELLSIDTERRHLRERVELLEKEI-QEHINAHHAYESQISSMAKAMSRLEE 958
+ E ++E L+ + RR L + + + EK++ Q+ +E Q+ + ++ L++
Sbjct: 1024 NQKE----QIESLT-EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQ 1078
Query: 959 ELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKS---- 1014
++ EK + +++ L+E +K D+ + + +QL K+ + + +K+
Sbjct: 1079 KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138
Query: 1015 -ESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEK--DTEIQLLKEKLTLSESK 1071
E DL K N + +E + DK S LTS K D E Q LK S
Sbjct: 1139 LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
Query: 1072 LTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERE 1108
L +S E L ++A +Q D K + E E
Sbjct: 1199 LEDKSLEFKKLSEELA-IQLDICCKKTEALLEAKTNE 1234
Score = 126 bits (317), Expect = 1e-28
Identities = 218/1083 (20%), Positives = 453/1083 (41%), Gaps = 151/1083 (13%)
Query: 45 ESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENN---ELYLELMKLREHSDQHVK 101
E L+Q ++ LE +++ + +EN E +EL L E + V
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172
Query: 102 ELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKK 161
EL + LK T D +F + + +H EK +K+ ++ + ++ + +Q K
Sbjct: 1173 ELTSKLK-----TTDEEFQSLKSSH-----EKSNKSLEDKSLEFKKLSEELAIQLDICCK 1222
Query: 162 RSIAFRRQR----MQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQ 217
++ A + + I + +S Q + + L + + EL+ ++ QL
Sbjct: 1223 KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282
Query: 218 EKLAMMESGVRDYSKQIELREREIERLSVALDG-GRSPDVLSLESRNK---TNEK----- 268
E+ + + + Q+E +E +I+ + ++ + L E N+ +EK
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCIT 1342
Query: 269 -LIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNK---------------- 311
L L+ ++ + ++L+++ E+ + +T V L N
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 312 -NEKLCQELTEIDQLA---QQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAK 367
+E+ C+ L ++ L+ L + K LE D + + K+ S + T+ +
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKE 1462
Query: 368 LQLELNLCQKEKERLSDEL-LVKSDLET-------VVHQLEQEKQRLSKKVESFAVTERQ 419
LQ++L L KE +++ L+K +L+ + ++E +K ++ KK + +
Sbjct: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Query: 420 LTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKEL-ERLQHIIQRRSCSTSYS 478
T + M LE I ++ L+ LK +++D KEL ++LQH +
Sbjct: 1523 QTARI--MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL-------- 1572
Query: 479 AREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSV 538
EK + + E+ E +Q+ + EL+ + E ++S + L A D+L
Sbjct: 1573 GEEKDNRVKEAEEKILTLE-NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE- 1630
Query: 539 LYNEAQEELSALRKESTQTTAP--HNIVSLMEKEKELA-------LSDLRRIMAEKEA-- 587
+E+ +L+ L++++ Q A ++S ME+++E LS+L + E+E
Sbjct: 1631 --SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV 1688
Query: 588 --LREKLEHIEE--------------VSLFGKSE-------LEKTIEHLTCVNHQLESEK 624
L EKL+ +E V+ + + E ++KT E V + +EK
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEK 1748
Query: 625 YELKSKVLIMKETIESLENKLKVQAQ----KFSHVAGDSSHQKTEVNSLRIVNEQLQRSV 680
+L +V KE S +++ Q Q K H ++ + L+ E+ +
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKY 1808
Query: 681 DDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVID----KEK 736
+ K G + QA+ + LE D++ + ++ ++++ I +D ++K
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQK 1867
Query: 737 DFLQETVDEKTEKIANLQ--ENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINS 794
+ + ++E T K LQ + + + K ++ E S + L N + + N
Sbjct: 1868 EVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHND 1927
Query: 795 LRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLEL----------EAA 844
L +L A +E ++G KE RLQ DL + +E+Q+ LE+ E
Sbjct: 1928 LEFKLAGAEREKQKLG-------KEIVRLQKDLRMLRKEHQQ-ELEILKKEYDQEREEKI 1979
Query: 845 VQEKEEMKSRVHKYITEVSR-WESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGE 903
QE+E+++ + + + ++ R + + +A KE Q+L + N+A++ E + ++ E
Sbjct: 1980 KQEQEDLELKHNSTLKQLMREFNTQLAQKE---QELEMTIKETINKAQEVEAELLESHQE 2036
Query: 904 SSSVRL-ELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRH 962
++ L ++ D + + +R E + +E + A ++ + + L+++ +
Sbjct: 2037 ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA------KVRDLQTQLEELQKKYQQ 2090
Query: 963 QEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQ 1022
+ +++ ND ++ EL +L + K + K EF + LE D LKK
Sbjct: 2091 KLEQEENPGNDNVTIMELQTQL-AQKTTLISDSKLKEQEFREQIHNLE------DRLKKY 2143
Query: 1023 LSN 1025
N
Sbjct: 2144 EKN 2146
Score = 120 bits (301), Expect = 7e-27
Identities = 189/1076 (17%), Positives = 468/1076 (43%), Gaps = 145/1076 (13%)
Query: 144 QLQEKNLHAVVQTP-------GGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIA 196
QL+ ++ ++ ++P K S+ R ++ S +S+ P D
Sbjct: 66 QLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAE 125
Query: 197 DLLQVADNRIQE-LQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPD 255
DL+ +D+ +E L Q + +++ L+ + ++ +RE ++L L
Sbjct: 126 DLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILS------ 179
Query: 256 VLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKE---TVTSEVVNLSNK- 311
+S++K+ + IA L ++ QQA K L++ +E K+ +V V+L +
Sbjct: 180 ----QSQDKSLRR-IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR 234
Query: 312 ------NEKLCQELTEIDQLAQQLERHK------EEVLE--TADKELGEAKKEIKRKLSE 357
N + + L +++ A+ + + E V+E T+ K L ++ +KR+ +
Sbjct: 235 LRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENL 294
Query: 358 MQDLEETMAKLQLELNLCQKEKERLSDELLVK-SDLETV--VHQLEQEK----QRLSKKV 410
++ +ET+ + + L EKE L ++L + +LE + +H E+ K R +K +
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNL 354
Query: 411 ESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQR 470
++ + + + ++ ++ ++ ++L + +K + + + +++ E+ +
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER-AAF 413
Query: 471 RSCSTSYSAREKSSIFRTPEKGDYNSEIHQITR----ERDELQRMLERFEKYMEDIQSNV 526
+ S +K+ R K + + +I I + ER LQ+ L R ++ + D+
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKK- 472
Query: 527 KLLTAERDKLSVLYNEAQEELSALRKESTQ--TTAPHNIVSLMEKEKELALSDLRRIMAE 584
+ ++++ L ++EL+ +E T+ T M+ E + S+ +I E
Sbjct: 473 ----SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 585 KEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENK 644
KE +++ +EE+ L K+ L ++ L + + E+ + + ++++++ +N+
Sbjct: 529 KE--QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Query: 645 LK-----VQAQKFSH---VAGDSSHQKTEVNSLR-----IVNEQLQRSVDDYQHRLSIKR 691
K ++A+K H + KTE+ SL+ + E+LQ YQ + R
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 692 GELESA------------QAQIKILEEK-IDELNLKMTSQD----------EEAHVMKKT 728
+ E QA I+ + EK +++L++K T + + H +++
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 729 IGVIDKEKDFLQETVDEKTEKIANLQE------------NLANKEKA----VAQMKIMIS 772
+ V+ + D +++ ++ K ++ N + ++ EKA + Q+++++
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
Query: 773 ECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMAR 832
E + + + + + N + +I +L A +LD + ++ + ++ LA + +
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 833 ENQEISLELEAAVQEKEEMKSRVHKYITEVS----RWESLMAAKEKENQDLLDRFQMLHN 888
+ ++ E ++ E++++ TE+ + + LM EK+N ++ + + L
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 889 RAEDWEVKAHQAEGESSSVRLELLSIDTERRH-LRERVELLEKEIQEHINAHH----AYE 943
E ++ + ++ + +E ++ + R ++ +E+L +++ ++ H YE
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 944 SQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFE 1003
++ + K M +++++ + ++ L D + KL + +L+ K +F
Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA------KLKKELENTALELSQKEKQFN 1000
Query: 1004 RVVVELENVKSE--SDLLKKQLSNERHTVKNLESLLATNRD-----------------KE 1044
++E+ S SD + + +N++ +++L + + +E
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 1045 FHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQI 1100
H + EK+ E+ LK+K+ L + ++E T L+ + + T + L+ Q+
Sbjct: 1061 IH-EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Score = 69.3 bits (168), Expect = 2e-11
Identities = 122/664 (18%), Positives = 255/664 (38%), Gaps = 77/664 (11%)
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+I+ E+ +LQ+ L + SN T R + S + E TQ+ A
Sbjct: 8 KISEEQQQLQQALAPAQA-----SSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 560 PH------NIVSLMEKE-KELALSDLRRIMAEKEALREKLEHIE----EVSLFGKSELEK 608
++ SL KE + + + RE L ++ S S+++
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS 122
Query: 609 TIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLK--------VQAQKFSHVAGDSS 660
E L + L E +L ++ M+ ++ S K +Q +K S
Sbjct: 123 EAEDLVGNSDSLNKE--QLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
Query: 661 HQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDE 720
Q + + + E+LQ +H LE I +L+ ++ L ++ +
Sbjct: 181 SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPM 240
Query: 721 EAHVMKKTIGVIDKEKDFLQE----TVDEKTEKIANLQENLANKEKAVAQMKIMISECES 776
V+K + + + F +E + E + + L ++ V + + ++ C+
Sbjct: 241 NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300
Query: 777 SVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRL------------- 823
++ KE E +L+ QLD +EL+++ +++ E +L
Sbjct: 301 TIQSHKEQCTLLTSEKEALQEQLDERLQELEKI---KDLHMAEKTKLITQLRDAKNLIEQ 357
Query: 824 --QDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLD 881
QD +A +++ LE +E +++SR+ + T+ E L KEK + +
Sbjct: 358 LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ---GEELREQKEKSERAAFE 414
Query: 882 RFQMLHNRAEDWEVKAHQAEGE-SSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHH 940
+ + A+ E + + E ++ + + ER L++ + +++E+ + +
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK--- 471
Query: 941 AYESQISSMAKAMSRLEEELRHQEDE--KATVLNDLSSLRELCIKLDSGKD----IMTQQ 994
+S +AK E+EL +E E K + ++ + L+ + I ++
Sbjct: 472 --KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 995 LNSKNLEFERVVVELENVKSESDLLKKQLSNERHT----VKNLESLLA------TNRDKE 1044
++L E + ++ + + +ES+ + L E T + LES L N+ K+
Sbjct: 530 EQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD 589
Query: 1045 FHSHL----TSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQI 1100
HL H K+ + + K K L K + L+ Q QT+ + L+ +
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 1101 STER 1104
E+
Sbjct: 650 EQEK 653
Score = 59.7 bits (143), Expect = 2e-08
Identities = 67/329 (20%), Positives = 149/329 (45%), Gaps = 35/329 (10%)
Query: 101 KELKTSLKKCARETADLKFLNNQYAHKLKLLEKESK-AKNERIQQLQEKNLHAVVQTPGG 159
KEL + + + D + + H++++ E SK K + +QQ+ +N +
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENT 1904
Query: 160 KKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEK 219
+++S + V P +S+ D + L A+ Q+L +E+ +LQ+
Sbjct: 1905 EEKSKSHL---------VQPKLLSNMEAQHNDLEF---KLAGAEREKQKLGKEIVRLQKD 1952
Query: 220 LAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDF 279
L M+ +++ +++E+ ++E ++ D L L+ N T ++L+ N Q
Sbjct: 1953 LRMLR---KEHQQELEILKKEYDQEREEKIKQEQED-LELK-HNSTLKQLMREFNTQ--- 2004
Query: 280 LQQANKDLEKRIRELMETKETVTSEVVNL-SNKNEKLCQELTEIDQLAQQLERHKEEVLE 338
L Q ++LE I+E + + V +E++ + +L +++ E D ++ + EE+L+
Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILD 2064
Query: 339 TADKELGEAKKEIKRKLSEMQDL------------EETMAKLQLELNLCQKEKERLSDEL 386
++E+ ++++ +L E+Q + + ++L+ L QK +SD
Sbjct: 2065 AREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTT-LISDSK 2123
Query: 387 LVKSDLETVVHQLEQEKQRLSKKVESFAV 415
L + + +H LE ++ K V + V
Sbjct: 2124 LKEQEFREQIHNLEDRLKKYEKNVYATTV 2152
Score = 52.0 bits (123), Expect = 3e-06
Identities = 75/356 (21%), Positives = 145/356 (40%), Gaps = 57/356 (16%)
Query: 770 MISECESSVNQL----KETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
M SE E V KE L+ R R + R L + + E+ + ++ +E ++LQ
Sbjct: 120 MDSEAEDLVGNSDSLNKEQLIQRLRR---MERSLSSYRGKYSELVTAYQMLQREKKKLQG 176
Query: 826 DLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQM 885
L+ ++Q+ SL A ++E+ +M + K++ E +++ + K++ L + +
Sbjct: 177 ILS----QSQDKSLRRIAELREELQMDQQAKKHLQE--EFDASLEEKDQYISVLQTQVSL 230
Query: 886 LHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQ 945
L R + + + + L + E+ KE + E
Sbjct: 231 LKQRLRNGPMN---------------VDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275
Query: 946 ISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERV 1005
S K + L++ ++ QE+ + S +E C L S K+ + +QL+ +
Sbjct: 276 TS--VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER------- 326
Query: 1006 VVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKL 1065
+ ELE +K K +L + KNL L E+D + + + K
Sbjct: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQL---------------EQDKGMVIAETKR 371
Query: 1066 TLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLAT 1121
+ E+ L + E LR+++ Q+ T + L+ Q + + ERA E L+T
Sbjct: 372 QMHET-LEMKEEEIAQLRSRIKQMTTQGEELREQ----KEKSERAAFEELEKALST 422
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 159 bits (401), Expect = 2e-38
Identities = 259/1182 (21%), Positives = 494/1182 (41%), Gaps = 189/1182 (15%)
Query: 12 IRKRLDQLGYRQTLTVE-CLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEP 70
+ +RLD L + T + CL L ++ +S+ +K+ E E ++ ++V E
Sbjct: 74 LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSV--TKMGDAHKELEQSHINYVKE- 130
Query: 71 YKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKL 130
+EN + NEL K E K+L+ ++ + LKF NN + KL
Sbjct: 131 --IENLK-----NELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKL 183
Query: 131 LEKESKAK---NERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPV 187
E+ K + E+I LQ K L A T KK +
Sbjct: 184 QEEIEKIRPGFEEQILYLQ-KQLDA---TTDEKKET------------------------ 215
Query: 188 PQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVA 247
+ L + + Q Q+ ++ LQE+L +++ + + E++ L
Sbjct: 216 -------VTQLQNIIEANSQHYQKNINSLQEELLQLKA----------IHQEEVKELMCQ 258
Query: 248 LDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVN 307
++ + N+ E L+ + + K+++K+ +E TS
Sbjct: 259 IEASAKEHEAEINKLNELKENLVKQ-------CEASEKNIQKKYECELENLRKATSN--- 308
Query: 308 LSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAK 367
+N++ ++C L + + +Q+ K + LE KEL +K +++ M +L K
Sbjct: 309 -ANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNL-----K 362
Query: 368 LQLELNLCQKEKE----------RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTE 417
L+LE++ + E ++++ LL K + V+ +L+ E L+K+ F T
Sbjct: 363 LKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ---FCYTV 419
Query: 418 RQLTLEVERMRLEHGIKRRDRSPSRL-DTFLKGIEEER-------DYYKKELERLQHIIQ 469
Q EV+ ++ +H + S L +TFL E+E+ K++ E LQ +
Sbjct: 420 EQHNREVQSLKEQH-----QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQ--E 472
Query: 470 RRSCSTSY-SAREKSSIFRT--------------PEKGDYNSEIHQITR-------ERDE 507
++ +Y S RE I +T K S++H++ + E+D
Sbjct: 473 KQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDA 532
Query: 508 LQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLM 567
L + R + E + S +L+ + + L + L +L + T ++ +
Sbjct: 533 LLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSL 592
Query: 568 EKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYEL 627
+EK+ ++ L+ E + +K E E + L EL K +E N +LE + EL
Sbjct: 593 TEEKDDFINKLKNSHEEMDNFHKKCEREERLIL----ELGKKVEQTIQYNSELEQKVNEL 648
Query: 628 K---SKVLIMKETIESLENKLKVQAQKFSH----VAGDSSHQKTEVNSLRIVNEQLQRSV 680
+ L K+ + KL VQ + S ++ + E N L +QL R +
Sbjct: 649 TGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDL 708
Query: 681 DDY--QHRLSIKRGELESAQAQIKILEEKIDELN-LKMTSQDEEAHVMKKTIGVIDKEKD 737
+ + Q I + + + +++++ E+ D LN L Q ++ V + G + +
Sbjct: 709 EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS 768
Query: 738 FLQETVDEK--TEKIANLQENLA--NKEKA--VAQMKIMISECESSVNQLKETLVNRDRE 791
+ E +EK + + E+LA N+EK Q + E E + L+E V + E
Sbjct: 769 EVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 828
Query: 792 INSLRRQLD----AAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQE 847
+ SL R + KEL+E+ +E LQ DL M N++ LE + + +
Sbjct: 829 LKSLLRDYEQEKVLLRKELEEIQSEKE-------ALQSDLLEMKNANEKTRLENQNLLIQ 881
Query: 848 KEEMKSRVHKYITEVSRWESLMAAKEKEN-QDLLDRFQMLHNRAEDWEVKAHQAEGESSS 906
EE+ K +E+ + KE EN + LL++ ++ RAE +K A +S S
Sbjct: 882 VEEVSQTCSK--SEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLA--KSPS 937
Query: 907 VRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDE 966
V+ + LS + L E++E LEKE +E E +I+ + + ++EL E
Sbjct: 938 VKNDPLS---SVKELEEKIENLEKECKEK-------EEKINKIKLVAVKAKKELDSSRKE 987
Query: 967 KATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNE 1026
TV +L SLR +L + + Q S ++ +++E E + D+ K++ +N
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAES----YKNLLLEYEKQSEQLDVEKERANNF 1043
Query: 1027 RHTVKNL-----------ESLLATNRDKEFH-SHLTSHEKDTEIQLL--KEKLTLSESKL 1072
H +++L E++ + N D L S+ K E+Q+L + + + +L
Sbjct: 1044 EHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKEL 1103
Query: 1073 TSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEM 1114
++ + + A + + L+ Q+ E+ + ++ +QE+
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQEL 1145
Score = 152 bits (383), Expect = 2e-36
Identities = 252/1194 (21%), Positives = 501/1194 (41%), Gaps = 153/1194 (12%)
Query: 33 VEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVL-EPYKLENARLSREN-NELYLELM 90
+E L ++L+ + K + K +E+ N L E K +N S +N +L E+
Sbjct: 131 IENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNN--SEDNVKKLQEEIE 188
Query: 91 KLREHSDQHVKELKTSL-------KKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQ 143
K+R ++ + L+ L K+ + ++ N+Q+ K +E + + I
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 144 QLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVAD 203
Q + K L ++ K+ + + V E S + + + + +L +
Sbjct: 249 QEEVKELMCQIEA-SAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATS 307
Query: 204 NRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRN 263
N Q+ Q LQE +E V + K +E +E+E +L E
Sbjct: 308 NANQDNQICSILLQEN-TFVEQVVNEKVKHLEDTLKELES---------QHSILKDEVTY 357
Query: 264 KTNEKLIAHLNIQ--VDFLQQANKDLEKRIRELMETKETVTSEVVNLSNK----NEKLCQ 317
N KL ++ Q D +DLE +I EL+ KE + L ++ N++ C
Sbjct: 358 MNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCY 417
Query: 318 ELTEIDQLAQQL-ERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQ 376
+ + ++ Q L E+H++E+ E + L +++KE + E+Q L+E LQ E
Sbjct: 418 TVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAI 477
Query: 377 KEKERLSD--ELL----------VKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLE- 423
E L + E+L + + E++ Q + L +K+ + A TE+ LE
Sbjct: 478 LNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRT-AFTEKDALLET 536
Query: 424 VERMRLEHG--IKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSARE 481
V R++ E+ + +++ P L+ +K ++E+ Y L + QR + +
Sbjct: 537 VNRLQGENEKLLSQQELVPE-LENTIKNLQEKNGVY------LLSLSQRDTMLKELEGKI 589
Query: 482 KSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYN 541
S T EK D+ +++ E D + ER E+ + ++ V+ +L N
Sbjct: 590 NSL---TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
Query: 542 EAQEELSALRKESTQTTAPHNIV----SLMEKEKELALSDLRRIMAEKEALR-EKLEHIE 596
E L KE Q + ++ ++KE+ ++++ + E L EK +
Sbjct: 647 ELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR 706
Query: 597 EVSLFGKSELEKTI--EHLTCVNHQLESEKYELKS-KVLIMKETIESLENKLKVQA--QK 651
++ +F S+ E I EH+T + +L+ E + L+ E ++ L K ++ ++
Sbjct: 707 DLEVF-LSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKE 765
Query: 652 FSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGE-LESAQAQIKILEEK--- 707
+ S +K VN L+ V E L + +++ + L+ +R E + + +IK L+E+
Sbjct: 766 MGSEVSEDSEEKDVVNVLQAVGESLAK-INEEKCNLAFQRDEKVLELEKEIKCLQEESVV 824
Query: 708 -IDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEK---TEKIANLQENLANKEKA 763
+EL + ++E +++K + I EK+ LQ + E EK +NL + +
Sbjct: 825 QCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884
Query: 764 VAQM-----------KIMISECESSVNQLKETLVNRDREIN------------SLRRQLD 800
V+Q K I E E+ + L E RDR S++
Sbjct: 885 VSQTCSKSEIHNEKEKCFIKEHEN-LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPL 943
Query: 801 AAHKELDEVGRSREIAFKENR-----------RLQDDLATMARENQEISLELEAAVQEKE 849
++ KEL+E + E KE + + +L + +E Q + ELE+ EK+
Sbjct: 944 SSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 850 EMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRL 909
++ + + I +++L+ EK+++ L + RA ++E + + + L
Sbjct: 1004 QLSASMRDLIQGAESYKNLLLEYEKQSEQL----DVEKERANNFEHRIEDLTRQLRNSTL 1059
Query: 910 ELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQE----- 964
+ +I+++ L R+E L+ + E QI + +A + +++EL ++
Sbjct: 1060 QCETINSDNEDLLARIETLQSNAK-------LLEVQILEVQRAKAMVDKELEAEKLQKEQ 1112
Query: 965 --DEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQ 1022
E AT +N+L L+ QL + + ++ + ELE VK ++
Sbjct: 1113 KIKEHATTVNELEELQ--------------VQLQKEKKQLQKTMQELELVKKDA------ 1152
Query: 1023 LSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTML 1082
++ T+ N+E KE + LT+ K+ +I+ L++++ + + K + E T L
Sbjct: 1153 ---QQTTLMNMEIADYERLMKELNQKLTN--KNNKIEDLEQEIKIQKQKQETLQEEITSL 1207
Query: 1083 RAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLATPPLSSTLRSPSHSPE 1136
++ V Q + +K+ + + E + Q H + L L + E
Sbjct: 1208 QSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVE 1261
Score = 151 bits (381), Expect = 4e-36
Identities = 246/1124 (21%), Positives = 479/1124 (42%), Gaps = 170/1124 (15%)
Query: 57 AEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETAD 116
+EKE F ++ K + L +E E L LRE + EL S K ++E
Sbjct: 448 SEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFES 507
Query: 117 LKFLNNQYAH----KLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQ 172
+K H KL+ E A E + +LQ +N + Q
Sbjct: 508 MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ----------------- 550
Query: 173 IDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE-------KLAMMES 225
E VP E + + + + Y+ L Q D ++EL+ +++ L E KL
Sbjct: 551 -QELVPELENTIKNLQEKNGVYLLSLSQ-RDTMLKELEGKINSLTEEKDDFINKLKNSHE 608
Query: 226 GVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANK 285
+ ++ K+ E ER I L ++ + E K NE L L + Q ++
Sbjct: 609 EMDNFHKKCEREERLILELGKKVE---QTIQYNSELEQKVNE-LTGGLEETLKEKDQNDQ 664
Query: 286 DLEK---RIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADK 342
LEK +++ L E KE +++EV +L +N KL E ++ + + KE+V+ +
Sbjct: 665 KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI--LKE 722
Query: 343 ELGEAKKEIKRKLSEMQDL-----EETMAKLQLELNLCQKEKERLSDELLVKSDLETVVH 397
+ + +K+++ + E +L E + KL ++ L KE + E+ S+ + VV+
Sbjct: 723 HITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKE-MGSEVSEDSEEKDVVN 781
Query: 398 QLEQEKQRLSKKVE-----SFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEE 452
L+ + L+K E +F E+ L LE E L+ + L + L+ E+
Sbjct: 782 VLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQ---EESVVQCEELKSLLRDYEQ 838
Query: 453 ERDYYKKELERLQ--------HIIQRRSCSTSYSAREKSSIFRTPEKGD--YNSEIHQ-- 500
E+ +KELE +Q +++ ++ + ++ + + E SEIH
Sbjct: 839 EKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898
Query: 501 ---ITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQT 557
+E + L+ +LE +K + D ++ + LL +D L+ + + LS++
Sbjct: 899 EKCFIKEHENLKPLLE--QKELRDRRAELILL---KDSLAKSPSVKNDPLSSV------- 946
Query: 558 TAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVN 617
KE E + +L + EKE EK+ I+ V++ K EL+ + + V
Sbjct: 947 -----------KELEEKIENLEKECKEKE---EKINKIKLVAVKAKKELDSSRKETQTVK 992
Query: 618 HQLE---SEKYELKSKVLIMKETIESLENKL-------------KVQAQKFSHVAGDSSH 661
+LE SEK +L + + + + ES +N L K +A F H D +
Sbjct: 993 EELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTR 1052
Query: 662 QKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEE 721
Q LR Q + D + L+ +E+ Q+ K+LE +I E+ D+E
Sbjct: 1053 Q------LRNSTLQCETINSDNEDLLA----RIETLQSNAKLLEVQILEVQRAKAMVDKE 1102
Query: 722 AHVMKKTIGVIDKEKDFLQE--TVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVN 779
K + KE+ + TV+E E LQ+ +K + +++++ + + +
Sbjct: 1103 LEAEK-----LQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 780 QLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISL 839
E + + +R + L ++L + +++++ + +I ++ LQ+++ +
Sbjct: 1158 MNME-IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITS---------- 1206
Query: 840 ELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQ 899
L+++VQ+ EE +++ + + + + L +K+ E L+ + + E++A Q
Sbjct: 1207 -LQSSVQQYEEKNTKIKQLLVKTKK--ELADSKQAETDHLILQASL------KGELEASQ 1257
Query: 900 AEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEE 959
+ E +++L I +E+ + E L+ ++H AY+ ++++ L+EE
Sbjct: 1258 QQVE--VYKIQLAEITSEKHKIHEH---LKTSAEQHQRTLSAYQQRVTA-------LQEE 1305
Query: 960 LRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS--KNLEFERVVVELENVKSESD 1017
R + E+ATV ++ S + +++ QQ N E E E E+++ D
Sbjct: 1306 CRAAKAEQATVTSEFESYKVRV------HNVLKQQKNKSMSQAETEGAKQEREHLEMLID 1359
Query: 1018 LLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSR 1077
LK +L + ++ ++ S L T E + L H K + + KE KL S
Sbjct: 1360 QLKIKLQDSQNNLQINVSELQT-LQSEHDTLLERHNKMLQETVSKE--AELREKLCSIQS 1416
Query: 1078 ENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLAT 1121
EN M++++ Q + + + ++ R +QE R + T
Sbjct: 1417 ENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET 1460
Score = 115 bits (288), Expect = 2e-25
Identities = 205/1030 (19%), Positives = 421/1030 (40%), Gaps = 157/1030 (15%)
Query: 198 LLQVADNRIQELQQEVHQLQEKLAMMESG--VRDYSKQIE---LREREIERLSVALDGGR 252
L+Q A +R EL++E+ +L+ K +G ++ +++++ L + E E+ ++L +
Sbjct: 40 LIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLK--K 97
Query: 253 SPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKN 312
+ E + + AH ++ + K++E ELM + + + NL +
Sbjct: 98 ENIKMKQEVEDSVTKMGDAHKELEQSHINYV-KEIENLKNELMAVRSKYSEDKANLQKQL 156
Query: 313 EKLCQ---ELTE-----------IDQLAQQLERHK---EEVLETADKELGEAKKEIKRKL 355
E+ EL+E + +L +++E+ + EE + K+L E K +
Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216
Query: 356 SEMQDLEETMAK-LQLELNLCQKEKERLS-------DELLVKSDL-----ETVVHQLEQE 402
+++Q++ E ++ Q +N Q+E +L EL+ + + E +++L +
Sbjct: 217 TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNEL 276
Query: 403 KQRLSKKVESFAVT-ERQLTLEVERMRLEHGIKRRDRSPSRL----DTFLKGIEEERDYY 457
K+ L K+ E+ +++ E+E +R +D + +TF++ + E+ +
Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
Query: 458 K----KELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLE 513
KELE QH I + + + + K + + Q + +
Sbjct: 337 LEDTLKELES-QHSILKDEVTYMNNLKLKLEM---------------------DAQHIKD 374
Query: 514 RFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKEL 573
F ED++ + L +++ + + + EL+ L K+ T HN
Sbjct: 375 EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN----------- 423
Query: 574 ALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT-----IEHLTCVNHQLESEKYELK 628
R + + KE ++++ + E L SE EK I+ L L+ EK E
Sbjct: 424 -----REVQSLKEQHQKEISELNETFL-SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAI 477
Query: 629 SKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQK-TEVNSLRIVNEQLQRSVDDYQHRL 687
++E +E L+ +L A K S Q+ ++V+ L+ D +
Sbjct: 478 LNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV 537
Query: 688 SIKRGELESAQAQ----------IKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKD 737
+ +GE E +Q IK L+EK L ++ +D ++ I + +EKD
Sbjct: 538 NRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD 597
Query: 738 FLQETVDEKTEKIANLQENLANKEKAVAQMKIMI-------SECESSVNQLKETLVNRDR 790
+ E++ N + +E+ + ++ + SE E VN+L L +
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK 657
Query: 791 EINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEE 850
E + ++L+ ++ + +E+ E + L ++ ++ E +++S +LE + +KE+
Sbjct: 658 EKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED 717
Query: 851 MKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLE 910
+ + H IT++ + LM E QD L++ +L N Q G + E
Sbjct: 718 VILKEH--ITQLEKKLQLMV----EEQDNLNK--LLENEQVQKLFVKTQLYGFLKEMGSE 769
Query: 911 LLSIDTERRH----LRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEE------- 959
+S D+E + L+ E L K +E N + ++ + K + L+EE
Sbjct: 770 -VSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 828
Query: 960 ----LRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSE 1015
LR E EK + +L ++ L S M LE + +++++E V
Sbjct: 829 LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT 888
Query: 1016 SDLLKKQLSNERHT--VKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLS----- 1068
K ++ NE+ +K E+L KE ++ E+ LLK+ L S
Sbjct: 889 CS--KSEIHNEKEKCFIKEHENLKPLLEQKEL------RDRRAELILLKDSLAKSPSVKN 940
Query: 1069 ---------ESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGL 1119
E K+ + +E K+ +++ K+++ + R E + +E+
Sbjct: 941 DPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRS 1000
Query: 1120 ATPPLSSTLR 1129
LS+++R
Sbjct: 1001 EKDQLSASMR 1010
Score = 103 bits (256), Expect = 1e-21
Identities = 193/952 (20%), Positives = 387/952 (40%), Gaps = 162/952 (17%)
Query: 6 ERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFD 65
+ K + + K + L ++ V+C L + L D LR+ +L +++EKE+ D
Sbjct: 805 DEKVLELEKEIKCL--QEESVVQCEEL-KSLLRDYEQEKVLLRK-ELEEIQSEKEALQSD 860
Query: 66 FVL-----EPYKLENARLSRENNELYLELMKLREHSDQH---VKE--------------- 102
+ E +LEN L + E+ K H+++ +KE
Sbjct: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920
Query: 103 -------LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQ 155
LK SL K D + K++ LEKE K K E+I +++ + A +
Sbjct: 921 RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE 980
Query: 156 TPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVA------------- 202
+K + + + + S + Q + Y LL+
Sbjct: 981 LDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
Query: 203 ---DNRIQELQQEVHQL-----------QEKLAMMESGVRDYSKQIELREREIERLSVAL 248
++RI++L +++ ++ LA +E+ ++ +K +E++ E++R +
Sbjct: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMV 1099
Query: 249 DGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL-METKETVTSEVVN 307
D + L E + K + + L LQ+ K L+K ++EL + K+ + ++N
Sbjct: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159
Query: 308 LS---------NKNEKLCQELTEIDQLAQQL--ERHKEEVLETADKELGEAKKEIKRKLS 356
+ N+KL + +I+ L Q++ ++ K+E L+ +EI S
Sbjct: 1160 MEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQ----------EEITSLQS 1209
Query: 357 EMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT 416
+Q EE K++ L K K+ L+D ++D + L+ E + ++VE + +
Sbjct: 1210 SVQQYEEKNTKIK---QLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQ 1266
Query: 417 ERQLTLEVERMR--LEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCS 474
++T E ++ L+ ++ R+ S + ++EE K E + +
Sbjct: 1267 LAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFE----- 1321
Query: 475 TSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERD 534
SY R + + + K +E +ER+ L+ ++++ + ++D Q+N+++ +E
Sbjct: 1322 -SYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSE-- 1378
Query: 535 KLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEH 594
L L+ E HN + L+ ++++ LREKL
Sbjct: 1379 ------------LQTLQSEHDTLLERHNKM-------------LQETVSKEAELREKLCS 1413
Query: 595 IEEVSLFGKSELEKTIEHLTCVNHQLESE-KYELKSKVLIMKETIESLENKL-KVQAQKF 652
I+ ++ KSE +T+ LT N L + + +++ ++T+E+L+ +L K++AQ F
Sbjct: 1414 IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
Query: 653 SHVAGDSSHQKTEVNSLRIVNEQLQRSVDDY----QHRLSIKRGE---------LESAQA 699
+ ++ V+S + + +R D H ++ + GE + SA
Sbjct: 1474 Q--LKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSAST 1531
Query: 700 QIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLAN 759
+ LE+ ++ K+ A K+ + + K L T L+E A
Sbjct: 1532 YTQSLEQLLNSPETKLEPPLWHAEFTKEEL--VQK----LSSTTKSADHLNGLLRETEAT 1585
Query: 760 KEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFK- 818
+ Q+K++ SE + R++E R+ AA+ E + + I K
Sbjct: 1586 NAILMEQIKLLKSEIRR---------LERNQE-----REKSAANLEYLKNVLLQFIFLKP 1631
Query: 819 --ENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESL 868
E RL + TM + + E +L A Q +EE SR + + + W L
Sbjct: 1632 GSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSWSGL 1683
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 159 bits (401), Expect = 2e-38
Identities = 199/918 (21%), Positives = 398/918 (43%), Gaps = 130/918 (14%)
Query: 238 EREIERLSVALDGGRSP--DVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELM 295
E E+ RL + +S + + + + +EK + L+ +D L Q K LE + EL
Sbjct: 1322 ENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELH 1381
Query: 296 ETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKL 355
T + + + E L EL ++ + L+ H++ V E+ +K + ++
Sbjct: 1382 RTVQKRQQQKDFIDGNVESLMTEL----EIEKSLKHHEDIV-----DEIECIEKTLLKRR 1432
Query: 356 SEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAV 415
SE+++ + +A+ + EL+ C KEK + + E +D + + Q E + + L ++ + AV
Sbjct: 1433 SELREADRLLAEAESELS-CTKEKTKNAVEKF--TDAKRSLLQTESDAEELERRAQETAV 1489
Query: 416 TERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCST 475
+ + D+ L K +E+ + ++ L+ + I+ +
Sbjct: 1490 N----------------LVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDF 1533
Query: 476 SYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDK 535
+++K + T E +I R D ++L+ E ++ + AE +K
Sbjct: 1534 QCLSKKKEKL--TEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKR-------AELEK 1584
Query: 536 LSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAE---KEALR--- 589
L Q+E++ L ++ L K++EL L + A+ +EALR
Sbjct: 1585 LKSQVTSQQQEMAVLDRQ------------LGHKKEELHLLQGSMVQAKADLQEALRLGE 1632
Query: 590 ----EKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL 645
EK HI EV + +E L+ +L + E K+++ ++K+ IE E L
Sbjct: 1633 TEVTEKCNHIREV--------KSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENL 1684
Query: 646 KVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILE 705
+V ++ S + K ++ L++ N +LQ + R+S ELE + Q+ +LE
Sbjct: 1685 QVVLRQMSK---HKTELKNILDMLQLENHELQGLKLQHDQRVS----ELE--KTQVAVLE 1735
Query: 706 EKIDELNLKMTSQDE-----------------------EAHVMKKTIGVIDKEKDFLQET 742
EK++ NL+ SQ + E+ ++ + + KEK+ LQE
Sbjct: 1736 EKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEK 1795
Query: 743 VDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAA 802
D +K+A + LA E+ + + + E +V +L++ L +R+ SL + A
Sbjct: 1796 CDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAM 1855
Query: 803 HKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEV 862
++L E RE LQ++LA + +L + ++ + S + ++
Sbjct: 1856 QQQLQE---KREAV----NSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI 1908
Query: 863 SRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLS----IDTER 918
S W + +KE + + Q+L N E+ ++K Q E ++ E S ++T +
Sbjct: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
Query: 919 RHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR 978
L+E+ LEKE+ + + S++ + + + L+EE R E + T+ L
Sbjct: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
Query: 979 ELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHT----VKNLE 1034
E QQL K+ E + E ++++++ LL+ Q ER V +L+
Sbjct: 2029 E-----------REQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLK 2077
Query: 1035 SLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYD 1094
L R + + L ++++ IQ KE T+ + R +++ ++ Q+Q +Y
Sbjct: 2078 EALKIQRSQLEKNLLEQKQENSCIQ--KEMATIELVAQDNHERARRLMK-ELNQMQYEYT 2134
Query: 1095 ALKRQISTERYERERAIQ 1112
LK+Q++ ++ R ++
Sbjct: 2135 ELKKQMANQKDLERRQME 2152
Score = 125 bits (313), Expect = 3e-28
Identities = 208/1023 (20%), Positives = 429/1023 (41%), Gaps = 183/1023 (17%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
EK +L H + L Q K S ++ E E + + + + E+ LE+ K
Sbjct: 1353 EKEMEELHHNIDDLLQEKKS-LECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSL 1411
Query: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
+H + V E++ K + ++L+ A +L L E ES+ + +EK +AV
Sbjct: 1412 KHHEDIVDEIECIEKTLLKRRSELR-----EADRL-LAEAESE-----LSCTKEKTKNAV 1460
Query: 154 VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213
+ K+ + +++ + V+ L AD +++ LQ +
Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVN---------------LVKADQQLRSLQADA 1505
Query: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273
L++ E +++ +K + ++ + + LS K EKL L
Sbjct: 1506 KDLEQHKIKQEEILKEINKIVAAKDSDFQCLS------------------KKKEKLTEEL 1547
Query: 274 NIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHK 333
++ A ++ + ++ L E++ + ++ L ++ + E+ L +QL K
Sbjct: 1548 QKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607
Query: 334 EEV------LETADKELGEAKK----EIKRKLSEMQDLEETMAKLQL---ELNLCQKEKE 380
EE+ + A +L EA + E+ K + +++++ + +L ELN+ E+
Sbjct: 1608 EELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISER- 1666
Query: 381 RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEH----GIK-R 435
K+ L + ++E+E++ L + + + +L ++ ++LE+ G+K +
Sbjct: 1667 --------KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQ 1718
Query: 436 RDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYN 495
D+ S L+ + EE K ELE LQ I Q+ +KG+
Sbjct: 1719 HDQRVSELEKTQVAVLEE----KLELENLQQISQQ-------------------QKGEIE 1755
Query: 496 SEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555
+ + R++ E++RM +QS V+ L+ E++ L QE+ K+
Sbjct: 1756 WQKQLLERDKREIERMTAESRA----LQSCVECLSKEKEDL-------QEKCDIWEKKLA 1804
Query: 556 QTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTC 615
QT +++ E+ ++ S+L ++ L+++L+ + L +++ +
Sbjct: 1805 QTK---RVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDI-------SA 1854
Query: 616 VNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQ 675
+ QL+ ++ + S ++E + ++++ L + Q H + HQ ++ +
Sbjct: 1855 MQQQLQEKREAVNS----LQEELANVQDHLNLAKQDLLHT---TKHQDVLLSE----QTR 1903
Query: 676 LQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD------------EEAH 723
LQ+ + ++ +R + E E+ Q Q+++L+ +I+E LK+ Q+ EE+
Sbjct: 1904 LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK 1963
Query: 724 VMKKTIGVIDKEKDFLQETVDEKT-------------EKIANLQEN---LANKEKAVAQM 767
+ + + +++ +E D+K+ E++ LQE + EK ++Q
Sbjct: 1964 LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQT 2023
Query: 768 KIMISECESSVNQLKETLVNRDREINS-------LRRQLDAAHKELDEVGRSREIAFKEN 820
K +SE E + + L+ +E +S LR Q K+ ++ S + A K
Sbjct: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
Query: 821 R-RLQDDLATMARENQEISLE---LEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKEN 876
R +L+ +L +EN I E +E Q+ E R+ K + ++ ++E K+ N
Sbjct: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQM-QYEYTELKKQMAN 2142
Query: 877 QDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRL---------ELLSIDTERRHLRERVEL 927
Q L+R QM + A + E +S L +L +I +L +E
Sbjct: 2143 QKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES 2202
Query: 928 LEKEIQEHINAHHAYESQISSMAKAMSR------LEEELRHQEDE-KATVLNDLSSLREL 980
L++ + +N E S M L E+LRH+ED KA + + +S E+
Sbjct: 2203 LKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEV 2262
Query: 981 CIK 983
IK
Sbjct: 2263 LIK 2265
Score = 105 bits (263), Expect = 2e-22
Identities = 148/803 (18%), Positives = 363/803 (45%), Gaps = 86/803 (10%)
Query: 357 EMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT 416
E +LE +++L+ ++ Q K + +E +++ Q E+E + L ++
Sbjct: 1317 EHHNLENEVSRLE---DIMQHLKSKKREERWMRASKR----QSEKEMEELHHNIDDLLQE 1369
Query: 417 ERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTS 476
++ L EVE L +++R + +D ++ + E + +K L+ + I+ C
Sbjct: 1370 KKSLECEVEE--LHRTVQKRQQQKDFIDGNVESLMTELEI-EKSLKHHEDIVDEIECIEK 1426
Query: 477 YSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERF---EKYMEDIQSNVKLLTAER 533
+ +S + R ++ +E +++ +++ + +E+F ++ + +S+ + L
Sbjct: 1427 TLLKRRSEL-READRLLAEAE-SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRA 1484
Query: 534 DKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLE 593
+ +V +A ++L +L+ ++ + H I K++E+ L ++ +I+A K++ + L
Sbjct: 1485 QETAVNLVKADQQLRSLQADA-KDLEQHKI-----KQEEI-LKEINKIVAAKDSDFQCLS 1537
Query: 594 HIEEVSLFGKSELEKTIEHLTC-VNHQLESEKYELKSKVLIM--KETIESLENKLKVQAQ 650
+E +L+K IE +H L+ K +S+VL+ + +E L++++ Q Q
Sbjct: 1538 KKKEKLTEELQKLQKDIEMAERNEDHHLQVLK---ESEVLLQAKRAELEKLKSQVTSQQQ 1594
Query: 651 KFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDE 710
+ + + H+K E L ++ + ++ D Q L + E+ I+ ++ ++E
Sbjct: 1595 EMAVLDRQLGHKKEE---LHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEE 1651
Query: 711 LNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIM 770
L+ + + + K + +I +E EK E+ NLQ L K ++K +
Sbjct: 1652 LSFQKGELNVQISERKTQLTLIKQEI--------EKEEE--NLQVVLRQMSKHKTELKNI 1701
Query: 771 ISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATM 830
+ + ++L+ + D+ ++ L + A +E E+ ++I+ ++ ++ +
Sbjct: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
Query: 831 ARENQEI------SLELEAAVQ----EKEEMKSRVHKYITEVSRWESLMAAKEKENQDLL 880
R+ +EI S L++ V+ EKE+++ + + ++++ + ++AA E+ ++
Sbjct: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
Query: 881 DRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKE---IQEHIN 937
+ L + + Q + S+ ++ ++ + + RE V L++E +Q+H+N
Sbjct: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
Query: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997
A + + + L E+ R Q+D +++ ++ E C K + K Q L +
Sbjct: 1882 L--AKQDLLHTTKHQDVLLSEQTRLQKD-----ISEWANRFEDCQKEEETKQQQLQVLQN 1934
Query: 998 K-----------NLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFH 1046
+ + F+R+ E E+ +S+ + K L ++H ++ + + D+
Sbjct: 1935 EIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLS 1994
Query: 1047 SHLTSHEK--------------DTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTD 1092
L + E+ + + K +L+ E +L +S E L+ + ++ D
Sbjct: 1995 KVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD 2054
Query: 1093 YDALKRQISTERYERERAIQEMR 1115
+ L+ Q TER + E+ + ++
Sbjct: 2055 FSLLRNQFLTERKKAEKQVASLK 2077
Score = 82.4 bits (202), Expect = 2e-15
Identities = 172/824 (20%), Positives = 336/824 (40%), Gaps = 147/824 (17%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENN--ELYLELMK 91
E+L SDL E L+Q + +A ++ + L YK++ A+ N Y E+ K
Sbjct: 322 EELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKID-AKFEPLNYYPSEYAEIDK 380
Query: 92 LREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQ-------- 143
+ S ++ + + A E+ +++ A ++K +E + + +N+ +
Sbjct: 381 APDESP-YIGKSRYKRNMFATESY---IIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLD 436
Query: 144 -QLQEKN------------LHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQP 190
QL++K LH ++ +++ + + Q++E + ++S
Sbjct: 437 TQLEDKEKKISAAQTRLSELHDEIEK--AEQQILRATEEFKQLEEAIQLKKISEAG---- 490
Query: 191 DDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDG 250
DLL ++ Q V++L+++ +E + ++I +++EI+ L +A+D
Sbjct: 491 -----KDLLY---KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
Query: 251 GRSPD-------------VLSLESRNKTNEKLIAHLNI---------------------- 275
S D L+ NK ++L + L+
Sbjct: 543 LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
Query: 276 QVDFLQQANKDLEKRIRELMETKETVTSEVVNLSN-------KNEKLCQELTEIDQLAQQ 328
Q+ + KDLE I L E T+ + N + E L Q LTE++Q Q
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
Query: 329 LERHKEEVLETADKELGEAKK------EIKRKLSEMQ-DLEETMAKLQLELNLCQKEKER 381
LE + E KEL E + E+ L + Q DL A+L+ LNL E +
Sbjct: 663 LEIVAMDA-ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQ 721
Query: 382 LSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGI------KR 435
L +EL + T + QLEQ + Q LE ER L++ + +
Sbjct: 722 LKEEL----EKVTRLTQLEQ--------------SALQAELEKERQALKNALGKAQFSEE 763
Query: 436 RDRSPSRLDTFLKGIEEERDYYKKELE----RLQHIIQRRSCSTSYSAREKSSIFRTPEK 491
+++ S L LK ++++ + K++L+ L H++ +AR + R +
Sbjct: 764 KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAAR-VDELRRKLKL 822
Query: 492 GDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS--- 548
G IH D L + L +K +I + K ERD+ V + QEE++
Sbjct: 823 GTGEMNIHS---PSDVLGKSLADLQKQFSEILARSKW---ERDEAQVRERKLQEEMALQQ 876
Query: 549 ---ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605
A +E + + + M +K + ++++ E L+E L+ +EE+ +
Sbjct: 877 EKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQ 936
Query: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL----KVQAQKFSHVAGDSSH 661
L++ E + QL + + K + +E + L+ +L K A + +
Sbjct: 937 LQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTI 996
Query: 662 QKTEVNSL-----RIVNEQLQ--RSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLK 714
K ++ SL +I E+ + + + + + + +L A+A+I++L+ + + +
Sbjct: 997 AKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
Query: 715 MTSQDEEAHV-MKKTIGVIDKEKDFLQETVDEKTEKIANLQENL 757
+ E+ V V++ EK L ET++ + +IA LQ L
Sbjct: 1057 FRLEMEKTGVGTGANSQVLEIEK--LNETMERQRTEIARLQNVL 1098
Score = 81.6 bits (200), Expect = 4e-15
Identities = 171/877 (19%), Positives = 361/877 (41%), Gaps = 141/877 (16%)
Query: 265 TNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQ 324
T ++ A ++ +++ +DLEK++ E E K T + + N+ +KL + L E
Sbjct: 257 TQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ-DKLNKSLKEEAM 315
Query: 325 LAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLE-----LNLCQKEK 379
L +Q + L T ++ L + E+ R + +LE+ +A +++ LN E
Sbjct: 316 LQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEY 375
Query: 380 ERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRD-- 437
+ K+ E+ + K+ + ES+ + Q +++++M + ++
Sbjct: 376 AEID-----KAPDESPYIGKSRYKRNMF-ATESYIIDSAQ-AVQIKKMEPDEQLRNDHMN 428
Query: 438 -RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNS 496
R + LDT L+ E++ + L S
Sbjct: 429 LRGHTPLDTQLEDKEKKISAAQTRL----------------------------------S 454
Query: 497 EIH-QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555
E+H +I + ++ R E F++ E IQ K+ A +D L + + ++ LR+E+
Sbjct: 455 ELHDEIEKAEQQILRATEEFKQLEEAIQLK-KISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
Query: 556 QTTAPHNIVSLMEKEK-ELA-----LSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT 609
++ MEK+K E+A + DL+ + ++ K H++ KS E+
Sbjct: 514 ------DLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA----QKSGKEQQ 563
Query: 610 IEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSL 669
++ + QLES E+ S++ E I+ LE +L + ++ +
Sbjct: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL----------------TEGQIAAN 607
Query: 670 RIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEE---AHVMK 726
+ + L+ + Q L +G+ AQ + + L ++ + L ++T ++E ++
Sbjct: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVA 667
Query: 727 KTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLV 786
+ KE L+ + E+ E A+LQ+ + A+++ ++ ++ NQLKE
Sbjct: 668 MDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKE--- 724
Query: 787 NRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAA-- 844
EL++V R ++ E LQ A + +E Q + L A
Sbjct: 725 ------------------ELEKVTRLTQL---EQSALQ---AELEKERQALKNALGKAQF 760
Query: 845 VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904
+EKE+ S +H + + +L+ + K+ Q+ L N D V+ +
Sbjct: 761 SEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHL-------NHVVDGLVRPEEVAARV 813
Query: 905 SSVRLEL------LSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEE 958
+R +L ++I + L + + L+K+ E I A +E + + + +L+E
Sbjct: 814 DELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE-ILARSKWERDEAQVRE--RKLQE 870
Query: 959 ELRHQEDEKATVLNDLSSLRELCIKLDSGKD-----IMTQQLNSKNLEFERVVVELENVK 1013
E+ Q+++ AT + E ++ D QQ+ ++ + + +E ++
Sbjct: 871 EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQ 930
Query: 1014 SESDLLKKQLSNERHTV-KNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKL 1072
+DL ++ E+ + L L + ++ S D E++ LK+ + S+
Sbjct: 931 GLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLA 990
Query: 1073 TSQSRENTMLRAKVAQLQTDYDALKRQISTERYERER 1109
T+ E T+ + ++ L + ++ + E E ER
Sbjct: 991 TA---ELTIAKDQLKSLHGTVMKINQERAEELQEAER 1024
Score = 62.0 bits (149), Expect = 3e-09
Identities = 76/475 (16%), Positives = 194/475 (40%), Gaps = 89/475 (18%)
Query: 672 VNEQLQRSVDDYQHRLSIKRGEL------ESAQAQIKILEEKIDELNLKMTSQDEEAHVM 725
+ ++ R D QH S KR E ++ +++ L ID+L + S + E +
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 726 KKTIGVIDKEKDFLQETVD--------EKT--------EKIANLQENLANKEKAVAQMKI 769
+T+ ++KDF+ V+ EK+ ++I +++ L + + +
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
Query: 770 MISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLAT 829
+++E ES ++ KE N + +R L + +E+ RR Q+
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEEL----------ERRAQETAVN 1490
Query: 830 MARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNR 889
+ + +Q++ L+A ++ E+ K + + + E+++ ++AAK+ + FQ L +
Sbjct: 1491 LVKADQQLR-SLQADAKDLEQHKIKQEEILKEINK---IVAAKDSD-------FQCLSKK 1539
Query: 890 AEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSM 949
E + E + L++ +E+ E+ H+ E + +
Sbjct: 1540 KE---------------------KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
Query: 950 AKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL 1009
+ +L+ ++ Q+ E A ++ +QL K E + +
Sbjct: 1579 RAELEKLKSQVTSQQQEMA---------------------VLDRQLGHKKEELHLLQGSM 1617
Query: 1010 ENVKSESD----LLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKL 1065
K++ L + +++ + + ++ ++SLL ++ ++ E+ T++ L+K+++
Sbjct: 1618 VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEI 1677
Query: 1066 TLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGLA 1120
E L R+ + + ++ + ++ + + ++ + E+ + +A
Sbjct: 1678 EKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
Score = 47.4 bits (111), Expect = 8e-05
Identities = 50/220 (22%), Positives = 91/220 (41%), Gaps = 20/220 (9%)
Query: 205 RIQELQQEVHQLQEKLAMME--SGVRDYSKQ--------IELREREIERLSVALDGGRSP 254
RIQ+++ E+H LQE L ME G+ D Q I + RE+E+ D
Sbjct: 908 RIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQE 967
Query: 255 DVLSLESRNKTNEKLIAH----LNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSN 310
V L+ K +K +A ++ + K L + ++ + + E S
Sbjct: 968 QVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSR 1027
Query: 311 KNEKLCQELTEID---QLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAK 367
K + ++LT + +L Q L R K E ++ G + L E++ L ETM +
Sbjct: 1028 KAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVL-EIEKLNETMER 1086
Query: 368 LQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLS 407
+ E+ Q + + K E V+ ++ + ++ +S
Sbjct: 1087 QRTEIARLQNVLDLTGSD--NKGGFENVLEEIAELRREVS 1124
Score = 47.0 bits (110), Expect = 1e-04
Identities = 108/563 (19%), Positives = 229/563 (40%), Gaps = 65/563 (11%)
Query: 5 VERKYINIRKRLDQLGYRQTL-TVECLPLVEKLFSDLVHTTESLRQS------------- 50
+ ++Y + RLD++ R T E L E+L + E+L++
Sbjct: 567 MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLG 626
Query: 51 --KLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLK 108
K A +A+ E E + +E ++L + M E+ + + EL+++L+
Sbjct: 627 TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA-ENMRKELAELESALQ 685
Query: 109 KCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIA--F 166
+ A L+ + LE ++ QL+E+ L V + ++ ++
Sbjct: 686 EQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE-LEKVTRLTQLEQSALQAEL 744
Query: 167 RRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESG 226
++R + + ++ S Q + A L + D+ L+Q++ Q L + G
Sbjct: 745 EKERQALKNALGKAQFSEEK-EQENSELHAKLKHLQDDN-NLLKQQLKDFQNHLNHVVDG 802
Query: 227 V---RDYSKQIELREREIERLSVALDGGRSPDVL--SLESRNKTNEKLIAHLNIQVDFLQ 281
+ + + +++ R+++ + ++ DVL SL K +++A + D Q
Sbjct: 803 LVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQ 862
Query: 282 QANKDLEKRI-----------RELMETKETVTSEVVNLSNKNE--KLCQELTEIDQLAQQ 328
+ L++ + E + E +N + ++ Q EI L +
Sbjct: 863 VRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQEN 922
Query: 329 LERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETM----AKLQLELNLCQKEKERL-- 382
L + EE+ D +L EA +E +R L+++++LE+ AK Q ++ KE ++L
Sbjct: 923 L-KSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKK 981
Query: 383 ----SDEL------LVKSDLETV---VHQLEQEKQRLSKKVESF----AVTERQLTLEVE 425
SD+L + K L+++ V ++ QE+ ++ E F A R LT
Sbjct: 982 AVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEA 1041
Query: 426 RMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSI 485
+ L + R+ RL+ G+ + E+E+L ++R+ + + +
Sbjct: 1042 EIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIA-RLQNVLDL 1100
Query: 486 FRTPEKGDYNSEIHQITRERDEL 508
+ KG + + + +I R E+
Sbjct: 1101 TGSDNKGGFENVLEEIAELRREV 1123
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 155 bits (393), Expect = 2e-37
Identities = 196/933 (21%), Positives = 395/933 (42%), Gaps = 95/933 (10%)
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLES 261
A+ + ++++ + +E+LA E+ R +E+E V+L ++ L L+
Sbjct: 849 AEKEMATMKEDFERTKEELARSEA-----------RRKELEEKMVSLLQEKND--LQLQV 895
Query: 262 RNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL---METKETVTSEVVNLSNKNEKLCQE 318
+++T + A + + L ++ LE +++EL +E +E + SE+V E C
Sbjct: 896 QSETENLMDAEE--RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 319 LT-EIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQK 377
L +ID L E L +KE + ++K EM LEE ++KL E Q+
Sbjct: 954 LKRDIDDL--------ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
Query: 378 EKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMR--LEHGIKR 435
++ D+L V+ D + ++ + ++ + +E E++L ++ER + LE +K
Sbjct: 1006 AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKM 1065
Query: 436 RDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYN 495
S L+ + IEE+ + EL +LQ I +
Sbjct: 1066 SQESIMDLENDKQQIEEKLKKKEFELSQLQAKID-------------------------D 1100
Query: 496 SEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555
++H + ++ +++ + R E+ E+I++ L + S L E +E L + S
Sbjct: 1101 EQVHSLQFQK-KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASG 1159
Query: 556 QTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTC 615
T+A + E E + DL + EA L + S+ +EL + I++L
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV---AELGEQIDNLQR 1216
Query: 616 VNHQLESEKYELKSKVLIMKETIESL-------ENKLKVQAQKFSHVAGDSSHQKTEVNS 668
V +LE EK ELK ++ M IE+L E + +FS + Q ++
Sbjct: 1217 VKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHD 1276
Query: 669 LRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKT 728
L + +LQ + HR+ K + + L ++++EL +M + + + M
Sbjct: 1277 LNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHA 1336
Query: 729 IGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNR 788
+ + D L+E +E+ E A LQ L+ VAQ + ++ E+ Q E L
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR---TKYETDAIQRTEELEEA 1393
Query: 789 DREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEK 848
++ L ++L A + + K +RLQ ++ + R+ + +++
Sbjct: 1394 KKK---LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQ 1450
Query: 849 EEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVR 908
+ ++ ++ ++ + A +KE++ L + N E + + ++R
Sbjct: 1451 RNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE-------EVVDQLETLR 1503
Query: 909 LELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKA 968
E ++ E L E++ K +QE E + S + A+ +E L H+E +
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL 1563
Query: 969 TVLNDLSSLRELCIKLDSGKDIMTQQL---NSKNLEFERVVVELENVKSESDLLKKQLSN 1025
V +LS ++ + KD +QL + + E + V++ E ++S +D L+ +
Sbjct: 1564 RVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAE-IRSRNDALRLK--- 1619
Query: 1026 ERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAK 1085
K +E L + HS+ E ++ ++ +L S+ L R N L+ +
Sbjct: 1620 -----KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Query: 1086 VAQLQTDYDAL-----KRQISTERYERERAIQE 1113
+A ++ L + +++ E+ ER R + E
Sbjct: 1675 LAIVERRNGLLLEELEEMKVALEQTERTRRLSE 1707
Score = 129 bits (325), Expect = 1e-29
Identities = 219/1147 (19%), Positives = 461/1147 (40%), Gaps = 145/1147 (12%)
Query: 52 LSAVKAEKESANFDFVLEPYKLENAR--------------LSRENNELYLE-------LM 90
L + +AEKE A E K E AR L +E N+L L+ LM
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 91 KLREHSDQHVKE---LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQ- 146
E + +K L+ +K+ + + +N++ K + LE + + I L+
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 147 -----EKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQV 201
EK HA K ++++ ++ + E S Q D LQV
Sbjct: 964 TLTKVEKEKHATEN----KVKNLSEEMTALEENISKLTKEKKSL---QEAHQQTLDDLQV 1016
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSK---QIELREREIE---RLSVALDGGRSPD 255
++++ L + +L+++ +E + K +E +R++E ++S D
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076
Query: 256 VLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKL 315
+E + K E ++ L ++D Q + +K+I+EL E + E+ K+
Sbjct: 1077 KQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI 1136
Query: 316 CQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLC 375
++ +++ + +++ EE ++ KK +DLEE + +
Sbjct: 1137 EKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Query: 376 QKEKERLSDELLVKSD-LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIK 434
+K++ EL + D L+ V +LE+EK L +++ A L+ + + I+
Sbjct: 1197 RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS------KSKSNIE 1250
Query: 435 RRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDY 494
R R+ + +K +E++ +L + +Q ++ S+ EK S+ K
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK- 1309
Query: 495 NSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKES 554
+T++ +EL+R +E K + ++ + D L Y E QE + L++
Sbjct: 1310 ----QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRAL 1365
Query: 555 TQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE---LEKTIE 611
++ + + K + A+ + K+ L ++L+ EE + S+ LEKT +
Sbjct: 1366 SKANS--EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQ 1423
Query: 612 HLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRI 671
L L + + + + + + L QK + + E SL
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483
Query: 672 VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGV 731
+++ + ++ +L R E ++ Q +I L E+I E + +EA KK +
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNL----QEAEKTKK---L 1536
Query: 732 IDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDRE 791
+++EK LQ ++E ++ +L ++E + ++++ +S+ +S +L ++ +D E
Sbjct: 1537 VEQEKSDLQVALEE-------VEGSLEHEESKILRVQLELSQVKS---ELDRKVIEKDEE 1586
Query: 792 INSLRRQ----LDAAHKELDEVGRSREIAFKENRRLQDDLATM----ARENQEIS----- 838
I L+R +A LD RSR A + ++++ DL M N++++
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646
Query: 839 ------------LELEAAVQEKEEMKSRV--------------HKYITEVSRWESLMAAK 872
L L+ A++ E++K ++ + + + E
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLS 1706
Query: 873 EKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKE- 931
E+E D DR Q+LH++ + E + + + E+ + E R+ E+ + +
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDA 1766
Query: 932 --IQEHINAHHAYESQISSMAKAMSRLEEELRHQEDE---------KATVLNDLSSLREL 980
+ E + + + M K + + ++L+H+ DE K + + +REL
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826
Query: 981 CIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATN 1040
+LD + + L + ++ER V E + Q + + L+ L+
Sbjct: 1827 ENELDVEQKRGAEALKGAH-KYERKVKE----------MTYQAEEDHKNILRLQDLV--- 1872
Query: 1041 RDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTD-YDALKRQ 1099
+ + + S+++ E + LS + E RA +A+ Q + A R
Sbjct: 1873 --DKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRD 1930
Query: 1100 ISTERYE 1106
+ +++ E
Sbjct: 1931 VGSQKME 1937
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 154 bits (390), Expect = 4e-37
Identities = 223/1118 (19%), Positives = 454/1118 (40%), Gaps = 137/1118 (12%)
Query: 45 ESLRQSKLSAVKAEKESANFDFVLEPYKLENARLS--RENNELYLELMKLREHSDQHVKE 102
++LR+ + K E E + + L + AR+ +E+N++ LE + E + +
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 103 LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKR 162
L + +E LK KL +E E ++I++L E+N+ +
Sbjct: 373 RSDKLHELEKENLQLKA-------KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 163 SIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQ---EK 219
S+ + QI SE P ++ ++ +R+ +L+ E L E+
Sbjct: 426 SLHLGWELEQISRTSELSEA-------PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 220 LAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDF 279
L V + +I E+E +RLS ++ + V +S N+ D
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ-------NLSKDL 531
Query: 280 LQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLET 339
+++ LEK I L E E ++ L +NE L Q ++ + Q +Q + + +E
Sbjct: 532 MKE-KAQLEKTIETLRENSER---QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 340 ADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQL 399
+K L E+ KE KLS K++ E +KE E ++ +LE +H L
Sbjct: 588 ENKILHESIKETSSKLS----------KIEFEKRQIKKELEHYKEKGERAEELENELHHL 637
Query: 400 EQEKQRLSKKVESFAVT-ERQLTLEVERMRLEHGIKRRDRSPSRLDTF------LKGIEE 452
E+E + L KK+ + +T E+ LE E LE ++ ++ LD+F L+ +E+
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT---LDSFKNLTFQLESLEK 694
Query: 453 ERDYYKKELERLQHIIQRRSCSTSYSAR----------EKSSI----------FRTPEKG 492
E +E L+ ++ C++ A+ EK + F+ E+
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL 754
Query: 493 DYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRK 552
+ + + I +R LQ+ LE K ++ ++S ++ L E L E + L +
Sbjct: 755 EVSYQGLDIENQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 553 ESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT--- 609
+ + S +EK+K+ + +R+ + E LE V + + KT
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE-NNVKIGNLEKENKTLSK 871
Query: 610 ---IEHLTCVN-HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
I +CV +LE E EL + I +T+ +L L + K + D E
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 666 VNSLRIVNEQL---QRSVDDYQHRLSIKRGELESA-QAQIKILEEKIDELNLKMTSQDEE 721
+ + + E+L ++S DD +++L +LES + ++I EEKI L ++
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKL--LESKLESTLKKSLEIKEEKIAALEARLEESTNY 989
Query: 722 AHVMKKTIGVIDKEKDFLQETVDEK-----------------------TEKIANLQENLA 758
+++ + + K + L++ DE+ T ++ +++ L
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 759 NKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFK 818
E+ A ++ ++ + QL+ N +I +L+RQ + ++ +
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109
Query: 819 ENRRLQDDLATMARENQEISL-------ELEAAVQEKEEMKSRVHKYITEVSRWESLMAA 871
EN L ++ +N ++ + E E+ ++E+E++KS I + + E L
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1169
Query: 872 KEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKE 931
+ E + L+ + L + ++ EV+ E + +LL + L + +++ +++
Sbjct: 1170 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN----QLLKQKGQLEDLEKMLKVEQEK 1225
Query: 932 IQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIM 991
+ H ++ + RL E + D +L+ L + +
Sbjct: 1226 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 992 TQQLNSKNLEFERVVVELENVKSESDLLKKQLSN----ERHTVKNLESLLATNR---DKE 1044
+ + +++++ + + ++ +LL + N RH + +++L+ NR ++
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345
Query: 1045 FHSHLTSH-------EKDTEIQLLKEKLTLSESKLTSQ 1075
S H +K E++ KEKL E K+ Q
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKL---EEKIMDQ 1380
Score = 134 bits (336), Expect = 6e-31
Identities = 195/913 (21%), Positives = 388/913 (42%), Gaps = 151/913 (16%)
Query: 285 KDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQ-----------QLERHK 333
K++ ++ L++ ++ + ++ LS + + L L AQ + +H
Sbjct: 191 KNMALHLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHL 249
Query: 334 EEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL----------S 383
L A ++ ++E++ K ++ D ++ + ++++EL Q+E L
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 384 DELLVKSDLETVVHQLEQEKQRLSKKVESFAV---------TERQLTLEVERM---RLEH 431
DEL + V +LE E R +++ + Q+ LE + M +LE
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 432 GIKRRDRSPS------RLDTFLKGIEEERDYYKKELERLQH------IIQRRSCSTS-YS 478
R D+ +L L +E ERD +K++E L + Q++S S +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 479 AREKSSIFRTPEKGD-----YNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAE 532
E I RT E + E++++T R +L+ + K +E++++ V +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 533 RDKLSVLYNEAQ---EELSALRKESTQTTAPHNIVSLMEKEKELALSDLRR-IMAEKEAL 588
K+ + E Q +++ L E Q EK+ +L + +M EK L
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQ-----------EKQSLQNCQNLSKDLMKEKAQL 538
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLT-CVNHQLESEKYELKSKVLIMKETIESLENKLKV 647
+ +E + E S LE+ EHL V+ + + +++V +++ + L +K
Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
Query: 648 QAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEK 707
+ K S + + K E+ + E+ + +++ H L + L+ +KI EK
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEK 657
Query: 708 IDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKI--ANLQ-----ENLANK 760
I+ L + + + E +KKT+ K F E+++++ ++ NL+ E+L
Sbjct: 658 IEALEQENSELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 761 EKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKEN 820
+AQ+++ E ES QLK+ L L A+ K+ + + S + EN
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGL-----------ELLKASFKKTERLEVSYQGLDIEN 765
Query: 821 RRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLL 880
+RLQ L ++ Q++ EL+ E + ++ + + R E L EKEN+ L
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL----EKENKSL- 820
Query: 881 DRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHH 940
E E+S + + ++ E + LR++ E+ + ++E+
Sbjct: 821 --------------------EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 941 AYESQISSMAKAMSRLEEE---LRHQEDEKATVLN----DLSSLRELCIKLDSGKDIMTQ 993
E + +++K + +E L+ E E ++ D+ +L L L S K + TQ
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK-LKTQ 919
Query: 994 QLNSKNLEFERVVVELENVKSESD-LLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSH 1052
Q+N+ + E++ ELE + + LL + S + K LES L + K
Sbjct: 920 QMNN---DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS-------- 968
Query: 1053 EKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQ 1112
+++ +EK+ E++L + N LR ++ ++ +Y+ALK +R + ER +Q
Sbjct: 969 -----LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK-----QRQDEERMVQ 1018
Query: 1113 EMRRHGLATPPLS 1125
++PP+S
Sbjct: 1019 -------SSPPIS 1024
Score = 45.4 bits (106), Expect = 3e-04
Identities = 70/392 (17%), Positives = 150/392 (38%), Gaps = 67/392 (17%)
Query: 43 TTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKE 102
TT L + K ++ E+ +A + K + +L +NN L +++ L+
Sbjct: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ--------- 1087
Query: 103 LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKR 162
R+T L+ N + L+ E+ N + L +N ++Q +
Sbjct: 1088 ---------RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
Query: 163 SIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAM 222
+ + ++R + + D L +++ L + E L
Sbjct: 1139 NESVIKEREDLKS-------------------LYDSLIKDHEKLELLHERQASEYESLIS 1179
Query: 223 MESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQ 282
++ K +E+ R++E R +L + + + EK+ L ++ + +
Sbjct: 1180 KHGTLKSAHKNLEVEHRDLE--------DRYNQLLKQKGQLEDLEKM---LKVEQEKMLL 1228
Query: 283 ANKDLEKRIRELMETKETVTSEVVNLSNKNEKL---CQELTEIDQLAQQLERHKEEVLET 339
NK+ ETV +E L +N++L +L + ++ Q ++ + +L
Sbjct: 1229 ENKN-----------HETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN 1277
Query: 340 ADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQL 399
+ E + E + + Q L+ T KL + L + K L +E + L+ + +
Sbjct: 1278 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE--NRHLLDQIQTLM 1335
Query: 400 EQEKQRLSKKVES---FAVTERQLTLEVERMR 428
Q + L + +ES F V +RQ ++ +R
Sbjct: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1367
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 154 bits (390), Expect = 4e-37
Identities = 220/1115 (19%), Positives = 447/1115 (40%), Gaps = 132/1115 (11%)
Query: 45 ESLRQSKLSAVKAEKESANFDFVLEPYKLENARLS--RENNELYLELMKLREHSDQHVKE 102
++LR+ + K E E + + L + AR+ +E+N++ LE + E + +
Sbjct: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 103 LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKR 162
L + +E LK KL +E E ++I++L E+N+ +
Sbjct: 373 RSDKLHELEKENLQLKA-------KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 163 SIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQ---EK 219
S+ + QI SE P ++ ++ +R+ +L+ E L E+
Sbjct: 426 SLHLGWELEQISRTSELSEA-------PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 220 LAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDF 279
L V + +I E+E +RLS ++ + V +S N+ D
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ-------NLSKDL 531
Query: 280 LQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLET 339
+++ LEK I L E E ++ L +NE L Q ++ + Q +Q + + +E
Sbjct: 532 MKE-KAQLEKTIETLRENSER---QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 340 ADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQL 399
+K L E+ KE KLS K++ E +KE E ++ +LE +H L
Sbjct: 588 ENKILHESIKETSSKLS----------KIEFEKRQIKKELEHYKEKGERAEELENELHHL 637
Query: 400 EQEKQRLSKKVESFAVT-ERQLTLEVERMRLEHGIKRRDRSPSRLDTF------LKGIEE 452
E+E + L KK+ + +T E+ LE E LE ++ ++ LD+F L+ +E+
Sbjct: 638 EKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT---LDSFKNLTFQLESLEK 694
Query: 453 ERDYYKKELERLQHIIQRRSCSTSYSAR----------EKSSI----------FRTPEKG 492
E +E L+ ++ C++ A+ EK + F+ E+
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL 754
Query: 493 DYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRK 552
+ + + I +R LQ+ LE K ++ ++S ++ L E L E + L +
Sbjct: 755 EVSYQGLDIENQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
Query: 553 ESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT--- 609
+ + S +EK+K+ + +R+ + E LE V + + KT
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE-NNVKIGNLEKENKTLSK 871
Query: 610 ---IEHLTCVN-HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
I +CV +LE E EL + I +T+ +L L + K + D E
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 666 VNSLRIVNEQLQRSVDDYQHRLSIKRGELESA-QAQIKILEEKIDELNLKMTSQDEEAHV 724
+ + + E+L R + +LES + ++I EEKI L ++
Sbjct: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991
Query: 725 MKKTIGVIDKEKDFLQETVDEK-----------------------TEKIANLQENLANKE 761
+++ + + K + L++ DE+ T ++ +++ L E
Sbjct: 992 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1051
Query: 762 KAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENR 821
+ A ++ ++ + QL+ N +I +L+RQ + ++ + EN
Sbjct: 1052 RNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1111
Query: 822 RLQDDLATMARENQEISL-------ELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEK 874
L ++ +N ++ + E E+ ++E+E++KS I + + E L +
Sbjct: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS 1171
Query: 875 ENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQE 934
E + L+ + L + ++ EV+ E + +LL + L + +++ ++++
Sbjct: 1172 EYESLISKHGTLKSAHKNLEVEHRDLEDRYN----QLLKQKGQLEDLEKMLKVEQEKMLL 1227
Query: 935 HINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQ 994
H ++ + RL E + D +L+ L + + +
Sbjct: 1228 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE 1287
Query: 995 LNSKNLEFERVVVELENVKSESDLLKKQLSN----ERHTVKNLESLLATNR---DKEFHS 1047
+ +++++ + + ++ +LL + N RH + +++L+ NR ++ S
Sbjct: 1288 FSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1347
Query: 1048 HLTSH-------EKDTEIQLLKEKLTLSESKLTSQ 1075
H +K E++ KEKL E K+ Q
Sbjct: 1348 KDLFHVEQRQYIDKLNELRRQKEKL---EEKIMDQ 1379
Score = 132 bits (332), Expect = 2e-30
Identities = 193/912 (21%), Positives = 385/912 (42%), Gaps = 150/912 (16%)
Query: 285 KDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQ-----------QLERHK 333
K++ ++ L++ ++ + ++ LS + + L L AQ + +H
Sbjct: 191 KNMALHLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHL 249
Query: 334 EEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL----------S 383
L A ++ ++E++ K ++ D ++ + ++++EL Q+E L
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 384 DELLVKSDLETVVHQLEQEKQRLSKKVESFAV---------TERQLTLEVERM---RLEH 431
DEL + V +LE E R +++ + Q+ LE + M +LE
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 432 GIKRRDRSPS------RLDTFLKGIEEERDYYKKELERLQH------IIQRRSCSTS-YS 478
R D+ +L L +E ERD +K++E L + Q++S S +
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
Query: 479 AREKSSIFRTPEKGD-----YNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAE 532
E I RT E + E++++T R +L+ + K +E++++ V +
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 533 RDKLSVLYNEAQ---EELSALRKESTQTTAPHNIVSLMEKEKELALSDLRR-IMAEKEAL 588
K+ + E Q +++ L E Q EK+ +L + +M EK L
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQ-----------EKQSLQNCQNLSKDLMKEKAQL 538
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLT-CVNHQLESEKYELKSKVLIMKETIESLENKLKV 647
+ +E + E S LE+ EHL V+ + + +++V +++ + L +K
Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
Query: 648 QAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEK 707
+ K S + + K E+ + E+ + +++ H L + L+ +KI EK
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEE-LENELHHLEKENELLQKKITNLKITCEK 657
Query: 708 IDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKI--ANLQ-----ENLANK 760
I+ L + + + E +KKT+ K F E+++++ ++ NL+ E+L
Sbjct: 658 IEALEQENSELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 761 EKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKEN 820
+AQ+++ E ES QLK+ L L A+ K+ + + S + EN
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGL-----------ELLKASFKKTERLEVSYQGLDIEN 765
Query: 821 RRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLL 880
+RLQ L ++ Q++ EL+ E + ++ + + R E L EKEN+ L
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL----EKENKSL- 820
Query: 881 DRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHH 940
E E+S + + ++ E + LR++ E+ + ++E+
Sbjct: 821 --------------------EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 941 AYESQISSMAKAMSRLEEE---LRHQEDEKATVLN----DLSSLRELCIKLDSGKDIMTQ 993
E + +++K + +E L+ E E ++ D+ +L L L S K + TQ
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK-LKTQ 919
Query: 994 QLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE 1053
Q+N+ + E++ ELE + + L + K LES L + K
Sbjct: 920 QMNN---DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS--------- 967
Query: 1054 KDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQE 1113
+++ +EK+ E++L + N LR ++ ++ +Y+ALK +R + ER +Q
Sbjct: 968 ----LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK-----QRQDEERMVQ- 1017
Query: 1114 MRRHGLATPPLS 1125
++PP+S
Sbjct: 1018 ------SSPPIS 1023
Score = 45.4 bits (106), Expect = 3e-04
Identities = 70/392 (17%), Positives = 150/392 (38%), Gaps = 67/392 (17%)
Query: 43 TTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKE 102
TT L + K ++ E+ +A + K + +L +NN L +++ L+
Sbjct: 1036 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ--------- 1086
Query: 103 LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKR 162
R+T L+ N + L+ E+ N + L +N ++Q +
Sbjct: 1087 ---------RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137
Query: 163 SIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAM 222
+ + ++R + + D L +++ L + E L
Sbjct: 1138 NESVIKEREDLKS-------------------LYDSLIKDHEKLELLHERQASEYESLIS 1178
Query: 223 MESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQ 282
++ K +E+ R++E R +L + + + EK+ L ++ + +
Sbjct: 1179 KHGTLKSAHKNLEVEHRDLE--------DRYNQLLKQKGQLEDLEKM---LKVEQEKMLL 1227
Query: 283 ANKDLEKRIRELMETKETVTSEVVNLSNKNEKL---CQELTEIDQLAQQLERHKEEVLET 339
NK+ ETV +E L +N++L +L + ++ Q ++ + +L
Sbjct: 1228 ENKN-----------HETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN 1276
Query: 340 ADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQL 399
+ E + E + + Q L+ T KL + L + K L +E + L+ + +
Sbjct: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE--NRHLLDQIQTLM 1334
Query: 400 EQEKQRLSKKVES---FAVTERQLTLEVERMR 428
Q + L + +ES F V +RQ ++ +R
Sbjct: 1335 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1366
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 154 bits (390), Expect = 4e-37
Identities = 236/1157 (20%), Positives = 505/1157 (43%), Gaps = 113/1157 (9%)
Query: 36 LFSDLVHTTESLR------QSKLSAVKAEKESA-NFDFVLEPYKLENARLSRENNELYLE 88
L ++L + T+ L+ Q +L+ ++ KE N D L+ + E ++ + + E
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923
Query: 89 LMKLREHSDQHVKELKTSL-------KKCARETADLKF-LNNQYAHKLKLLEKESKAKN- 139
+ L + D +K+L+ SL K +T ++ Q + L+ L++ + N
Sbjct: 924 VKTLTQEKDD-LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT 982
Query: 140 --ERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQID--EPVPPSEVSSYPVPQPDDPYI 195
+I + +NLH T K F+++ + ID + + + D+ I
Sbjct: 983 LKSKISEEVSRNLHMEENTGETKDE---FQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 196 ADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPD 255
++ + IQE + L+ +A E D + IE+ E L + D +
Sbjct: 1040 EQQRKIF-SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
Query: 256 VLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKL 315
+ + +N +K L+ D L + + L+++ ++L E ++ +++N+ + ++
Sbjct: 1099 EIVAQEKNHAIKKE-GELSRTCDRLAEVEEKLKEKSQQLQEKQQ----QLLNVQEEMSEM 1153
Query: 316 CQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLC 375
+++ EI+ L +L ++KE LE + E + E+ +KL+E + +++ K + L
Sbjct: 1154 QKKINEIENLKNEL-KNKELTLEHMETE----RLELAQKLNENYEEVKSITKERKVLKEL 1208
Query: 376 QKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEH---- 431
QK E D L + + + Q K+ L K+ + E Q T++ R +
Sbjct: 1209 QKSFETERDHL--RGYIREIEATGLQTKEEL--KIAHIHLKEHQETIDELRRSVSEKTAQ 1264
Query: 432 --GIKRRDRSPSRLDTFLKGIEEERDYYK--KELERLQHIIQRRSCSTSYSAREKSSIF- 486
+ ++S ++L + + EE++ KE+ Q + T S + S+
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLA 1324
Query: 487 -------RTPEK-GDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSV 538
R EK + EI +T+ERD L+ + E E + ++ +++ A+ +
Sbjct: 1325 RIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK-----I 1379
Query: 539 LYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLE--HIE 596
+++++E S KE T IVS ME+ K S L RI E L ++L+ H E
Sbjct: 1380 QESQSKQEQSLNMKEKDNETT--KIVSEMEQFKPKD-SALLRIEIEMLGLSKRLQESHDE 1436
Query: 597 EVSLFG-KSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHV 655
S+ K +L++ E L + QL+ E+ +K L +E ++ LK Q + + +
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 656 AGDSSHQKTEVNS----LRIVNEQLQRSVDDY---QHRLSIKR--------GELESAQAQ 700
+ S ++TE+++ L +N++LQ + + + + +IK+ EL+ +
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556
Query: 701 IKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANK 760
K + + + KM ++ I ++ KEK+ ++ + + L+EN
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENT--- 1613
Query: 761 EKAVAQMKIMISECESSVNQLKETLVNRDRE----INSLRRQLDAAHKELDEVGRSREIA 816
++ VA+MK E LK T VN +E I L+ Q + L+ +
Sbjct: 1614 KEIVAKMK---ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRL 1670
Query: 817 FKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYIT-EVSRWESLMAAKE-- 873
+ +++ ++ +E ++ E E++++K + + IT ++ + E L
Sbjct: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
Query: 874 KENQDLLDRFQ-MLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERR----HLRERVELL 928
KE+Q+ +D+ + ++ + + E + +++ + L I E R HL+E+ E +
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
Query: 929 EKE---IQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLD 985
+K + E + + + + + +EL+ E + T+ D++ ++ +++
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 986 S-GKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKE 1044
K I Q L LE E + + + ++ ++ K + ER ++ +E L RD+
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEM--KSVMKERDNLRRVEETLKLERDQL 1908
Query: 1045 FHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTM--LRAKVAQLQTDYDALKRQIST 1102
S + +D EIQ L +++ S+ + T+ LR K+++ +++ +
Sbjct: 1909 KESLQETKARDLEIQ-----QELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963
Query: 1103 ERYERERAIQEMRRHGL 1119
+ E ++ IQE+++ L
Sbjct: 1964 SKDELQKKIQELQKKEL 1980
Score = 148 bits (374), Expect = 3e-35
Identities = 223/1192 (18%), Positives = 528/1192 (44%), Gaps = 178/1192 (14%)
Query: 33 VEKLFSDLVHTTESLRQ-----SKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYL 87
++K + V E+LR+ S+L ++ +E E + ++ E ++ E ++L+
Sbjct: 725 LQKELNKEVEENEALREEVILLSELKSLPSEVERLRKE--IQDKSEELHIITSEKDKLFS 782
Query: 88 ELMKLREHSDQHVKEL----------KTSLKKCARETADLKFLNNQYAHKLKLLEKESKA 137
E++ ++E+ +++ K +E + K L+ + K K++ +E++
Sbjct: 783 EVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842
Query: 138 KNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIAD 197
N+ I L K + G K ++++ Q +Q +
Sbjct: 843 MNQEIVNLS-KEAQKFDSSLGALKTELSYKTQELQ------------------------E 877
Query: 198 LLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVAL----DGGRS 253
+ R+ E++Q QL+ + + +++ R+ + E ++ +E + D +
Sbjct: 878 KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 254 PDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLE--KRIRELMETKETVTSEVV----- 306
+ L +E R++ + +N+ +D +Q LE K+ +E + T ++ SE V
Sbjct: 938 QESLQIE-RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 307 ---NLSNKNEKLCQELTEIDQLAQQLERHKEEVL--ETADKELGEAKKEIKRKLSEMQDL 361
N ++ Q++ ID+ Q LE + L + D E+ E +++I + E +L
Sbjct: 997 MEENTGETKDEFQQKMVGIDK-KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNEL 1055
Query: 362 EETMAKLQLELNLCQKE-KERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQL 420
++ + + E + + KE + + + +L + +L+++++ ++++ E +L
Sbjct: 1056 QQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115
Query: 421 TLEVERM-RLEHGIKRRDRSPSRLDTFLKGIEEERDYYKK---ELERLQHIIQRRSCSTS 476
+ +R+ +E +K + + L ++EE +K E+E L++ ++ + +
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175
Query: 477 YSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVK------LLT 530
+ E+ + + + + E+ IT+ER L+ + + FE + ++ ++ L T
Sbjct: 1176 HMETERLELAQ--KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT 1233
Query: 531 AERDKLSVLY-NEAQEELSALRKESTQTTAPHNIVSLMEKEKE-LALSDLRRIMAEKEAL 588
E K++ ++ E QE + LR+ ++ TA I++ + EK L + ++ E++ L
Sbjct: 1234 KEELKIAHIHLKEHQETIDELRRSVSEKTA--QIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLE--NKLK 646
L +++EVS E ++T+ L +L +E+ K + + +E L K +
Sbjct: 1292 ---LPNVKEVS-----ETQETMNEL-----ELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338
Query: 647 VQAQKFSHVAGDSSHQKTEVNSLRIVNEQL-----------QRSVDDYQHRLSIKRGELE 695
++ + + + KT +L + ++QL Q S + L++K + E
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 696 -----SAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQ---ETVDEKT 747
S Q K + + + ++M + + + KEKD LQ E + ++
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
Query: 748 EKIA-NLQENLANKEKAVAQMKIM---ISECESSVNQLKETLVNRDREINSLRRQLDAAH 803
+++ N++E +A + ++K+ + E E ++N+L+ L ++ EI+++++QL+A +
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518
Query: 804 KEL----------DEVGRSREIA-----------FKENRRLQDD--------LATMAREN 834
+L +E ++I+ FKE+R+ +D + +
Sbjct: 1519 DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
Query: 835 QEISLELEAAVQEKEEMKSRVHKYI----TEVSRWESLMAAKEKENQDLLDRFQMLH--N 888
QE E++ ++EKEEMK RV + + ++ + AK KE+Q+ +F + N
Sbjct: 1579 QESQEEIQIMIKEKEEMK-RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN 1637
Query: 889 RAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISS 948
++ + + + + +L L +I+TE L ++L + ++E + + + S
Sbjct: 1638 ETQEKMCEIEHLKEQFETQKLNLENIETENIRL---TQILHENLEE-MRSVTKERDDLRS 1693
Query: 949 MAKAMSRLEEELRHQEDEKATVLNDLSSLRELCI----------KLDSGKDIMTQQLN-- 996
+ + + ++L+ E+ + T+ DL EL I +D + I++++ N
Sbjct: 1694 VEETLKVERDQLK--ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEI 1751
Query: 997 ---SKNLEFERVVVELENVKSESDL--LKKQLSNERHTVKNLESLLATNRDKEFHSHLTS 1051
K+LE ++ +++K + +L L ++ T+ L +++ DK +
Sbjct: 1752 SNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL 1811
Query: 1052 HEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTE 1103
+ ++Q ++L +E +L + ++ + KV+++ + LK+QI +
Sbjct: 1812 ENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM----EQLKKQIKDQ 1859
Score = 139 bits (351), Expect = 1e-32
Identities = 255/1318 (19%), Positives = 538/1318 (40%), Gaps = 256/1318 (19%)
Query: 1 MTTAVERKYINIRKRLDQLGYRQT----LTVECLPLVEKLFSDLVHTTESLRQSKLSAVK 56
+TT + IN+ + +D+ ++ T++ L +E + + E++ +S+L++++
Sbjct: 446 ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENI-ESELNSLR 504
Query: 57 AEKESANFDFV-LEPYKLENARLSRENNEL-YLELMKLREHSDQH------VKELKTSLK 108
A+ ++ D+ L K E +E N+L E ++ + DQ + LK +K
Sbjct: 505 ADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVK 564
Query: 109 KCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRR 168
DL+ N+ + K++LL + K ++I++LQE + Q K +++
Sbjct: 565 HAEVYNQDLE---NELSSKVELLRE----KEDQIKKLQE---YIDSQKLENIKMDLSYSL 614
Query: 169 QRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVR 228
+ I++P + D ++N EL++++ +L ME+ ++
Sbjct: 615 E--SIEDPKQMKQTLFDAETVALDAKRESAFLRSENL--ELKEKMKELATTYKQMENDIQ 670
Query: 229 DYSKQIELRER--------------EIERLSVALDGGRSPDVL--------------SLE 260
Y Q+E +++ EI +L+ +DG D+L L
Sbjct: 671 LYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELN 730
Query: 261 SRNKTNEKL---------IAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNK 311
+ NE L + L +V+ L++ +D + + + K+ + SEVV+ ++
Sbjct: 731 KEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR 790
Query: 312 NEKLCQELTEI-DQLA-------------------------------QQLERHKEEV--- 336
+ L +E+ + D LA ++ ER +E+
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL 850
Query: 337 -----------------LETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEK 379
L +EL E +E++ +L+EM+ L+E + L ++EK
Sbjct: 851 SKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREK 910
Query: 380 ERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE---------RMRLE 430
++++L + LE V L QEK L + ES + QL ++ + +L
Sbjct: 911 TLITEKL--QQTLEE-VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967
Query: 431 HGIKRRDRSPSRLDTFLKGIEEE--RDYY--------KKELERLQHIIQRRSCSTSYSAR 480
+ ++ + ++T I EE R+ + K E ++ I ++ + + +
Sbjct: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027
Query: 481 EKSSIFRTPEKGDYNSEIHQITRERDELQRMLERF----EKYMEDIQSNVKLLTAERDKL 536
++ + E + +I + +E++ELQ+MLE E+ D++ N+++ +++L
Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087
Query: 537 SVLYNE--------AQEELSALRKESTQTTAPHNIVSLMEKEKELA------LSDLRRIM 582
+L +E AQE+ A++KE + + + EK KE + L +
Sbjct: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147
Query: 583 AEKEALREKLEHIEEVSLFGKSEL---EKTIEHLTCVNHQLESEKYELKSKVLIMKETIE 639
E +++K+ IE + K+EL E T+EH +E+E+ EL K+ E ++
Sbjct: 1148 EEMSEMQKKINEIENL----KNELKNKELTLEH-------METERLELAQKLNENYEEVK 1196
Query: 640 SLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQA 699
S+ + KV + + H + + + Q + EL+ A
Sbjct: 1197 SITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE--------------ELKIAHI 1242
Query: 700 QIKILEEKIDELNLKMT--------SQD-EEAHV-MKKTIGVIDKEKDFLQETVDEKTEK 749
+K +E IDEL ++ +QD E++H +++ I V+ +E++ L V E +E
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL-PNVKEVSET 1301
Query: 750 IANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ----------L 799
+ E E++ + ++ E +L E EI SL ++ L
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361
Query: 800 DAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEIS--------------------- 838
+ H +L E R +E++ Q+ M ++ E +
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421
Query: 839 --LELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVK 896
L L +QE + V K ++ R + ++ ++ + ++ + H E+
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481
Query: 897 AH----QAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKA 952
AH + E + +R+ L +TE +++++E + ++Q I YE + K
Sbjct: 1482 AHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI--QEIYEKEEQFNIKQ 1539
Query: 953 MSRLEE---ELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL 1009
+S ++E EL+ ++ + + L S+ ++L T +L E + ++ E
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL-------TNRLQESQEEIQIMIKEK 1592
Query: 1010 ENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFH-----SHLTSHEKDTEIQLLKEK 1064
E +K + L+ + + K + + + +++KE+ + + EK EI+ LKE+
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 1065 LTLSESKLTSQSRENTMLR-------AKVAQLQTDYDALKRQISTERYERERAIQEMR 1115
+ L + EN L ++ + + D L+ T + ER++ + +R
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLR 1710
Score = 107 bits (268), Expect = 5e-23
Identities = 173/882 (19%), Positives = 381/882 (43%), Gaps = 88/882 (9%)
Query: 287 LEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGE 346
L++ +E+M+ K+ + E V+L + + + E DQLAQ LE ++++L+ E E
Sbjct: 345 LKRYRKEIMDLKKQL--EEVSLETRAQAM-----EKDQLAQLLE--EKDLLQKVQNEKIE 395
Query: 347 AKKEIKRKLSEMQDLEETMAKLQLELNLC-----QKEKERLSDELLVKSDLETVVHQLEQ 401
+ S + +E AK + + C + + +D+ + +++ T H+L
Sbjct: 396 NLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI 455
Query: 402 EKQRLSKKVESFAVTERQL---TLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYK 458
L ++++ +E + TL+ +E + + +++ L + + D
Sbjct: 456 N---LLREIDESVCSESDVFSNTLDT-LSEIEWNPATKLLNQENIESELNSLRADYDNLV 511
Query: 459 KELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKY 518
+ E+L+ ++ + F E+ + Q+ E L+ +++ E Y
Sbjct: 512 LDYEQLR--TEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 519 MEDIQ----SNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLME-KEKEL 573
+D++ S V+LL + D++ L QE + + + E+ + +++ S+ + K+ +
Sbjct: 570 NQDLENELSSKVELLREKEDQIKKL----QEYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625
Query: 574 ALSDLRRIMAEKEALREKLEHIEEVSLFGKSE---LEKTIEHLTCVNHQLESEKYELKSK 630
L D AE AL K E S F +SE L++ ++ L Q+E++ +S+
Sbjct: 626 TLFD-----AETVALDAKRE-----SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQ 675
Query: 631 VLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIK 690
+ K+ LE +L+ F+ + +S +V + N +L+ + D Q L+ +
Sbjct: 676 LEAKKKMQVDLEKELQ---SAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE 732
Query: 691 RGELESAQAQIKILEE------KIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVD 744
E E+ + ++ +L E +++ L ++ + EE H+ I EKD L V
Sbjct: 733 VEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHI-------ITSEKDKLFSEVV 785
Query: 745 EKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHK 804
K ++ L E + + +A + + K ++ +++ + + + ++
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 805 ELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSR 864
E+ + + + L+ +L+ +E QE + E++ + E E++K ++ + +
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 865 WESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLEL-----LSIDTERR 919
E ++ Q L+ + L +D + + E ++ ++ ++IDT+ +
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 920 HLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVL------ND 973
LR +E L K+ QE IN +S+IS +EE +DE + D
Sbjct: 966 -LRNALESL-KQHQETIN---TLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 974 LSSLRELCIKLD-SGKDIMTQQLNSKNLEFERVVVE--LENVKSESDLLKKQL-SNERHT 1029
L + + D +I+ QQ +L E+ ++ LE+V +E + LK L N T
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 1030 VKNLESLLATNRDKEFHSHLTSHE------KDTEIQLLKEKLTLSESKLTSQSRENTMLR 1083
++N E L + + + + E K+ E+ ++L E KL +S++ +
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140
Query: 1084 AKVAQLQTDYDALKRQIS-TERYERERAIQEMRRHGLATPPL 1124
++ +Q + ++++I+ E + E +E+ + T L
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Score = 101 bits (251), Expect = 5e-21
Identities = 221/1140 (19%), Positives = 463/1140 (40%), Gaps = 193/1140 (16%)
Query: 33 VEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKL 92
++ + S ++ T L++S+ KE V E ++E +L E+ ++ +
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623
Query: 93 REHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHA 152
+E Q +K T++ + + +++ L Q+ + KL + + +N R+ Q+ +NL
Sbjct: 1624 QEKEYQFLK--MTAVNETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLTQILHENLEE 1680
Query: 153 V--VQTPGGKKRSI--AFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQE 208
+ V RS+ + +R Q+ E + E + + + ++ L++ ++E
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENL--RETITRDLEKQEE------LKIVHMHLKE 1732
Query: 209 LQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEK 268
Q+ + +L+ ++ + + + K +E ++ + + + L+ + +T +K
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
Query: 269 LIAHLNIQVDFLQQANKDLE-------------------------------KRIRELMET 297
L ++ + D L KDLE K++ E+ +
Sbjct: 1793 LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852
Query: 298 KETVTSEVVNLS-------NKNEKLCQELTEIDQLAQQLE--RHKEEVLETADKELGEAK 348
K+ + + + LS N +KL + L E+ + ++ + R EE L+ +L E+
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912
Query: 349 KEIKRKLSEMQDLEETMAKLQLE-LNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLS 407
+E K + E+Q +T L E K +E++S++ + SD++ L++ K L
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ---KDLDKSKDELQ 1969
Query: 408 KKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHI 467
KK++ E QL E + + H K I E + KK+ E
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSH----------------KKI-NEMEQLKKQFE----- 2007
Query: 468 IQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVK 527
+ + S + + T + + EI + +ERDEL+R+ E
Sbjct: 2008 ----AQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES------------- 2050
Query: 528 LLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEA 587
L ERD+ ++ LR+ + H + K ++ LSD ++ + E+
Sbjct: 2051 -LKMERDQF----------IATLREMIARDRQNHQV-----KPEKRLLSDGQQHLT--ES 2092
Query: 588 LREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKV 647
LREK I+E+ L SE++ +H C+N +L+ ++ KE ++ L +
Sbjct: 2093 LREKCSRIKEL-LKRYSEMD---DHYECLNRL----SLDLEKEIEFQKELSMRVKANLSL 2144
Query: 648 QAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEK 707
+ H + L N++ HR+ K + S +IK EE+
Sbjct: 2145 PYLQTKH-----------IEKLFTANQRCSMEF----HRIMKKLKYVLSYVTKIK--EEQ 2187
Query: 708 IDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQM 767
+ +N +E K+ + I LQ+ D + ++ +L+ N N + + ++
Sbjct: 2188 HESINKFEMDFIDEVEKQKELLIKI----QHLQQDCDVPSRELRDLKLN-QNMDLHIEEI 2242
Query: 768 KIMISECE--SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
SE E S + ++ L NR L L+ ++ + + KEN R+
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF----DIEKLKNGIQKENDRI-- 2296
Query: 826 DLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQM 885
+ N + + A + E E + R T WE + + +++N+ L +Q
Sbjct: 2297 -----CQVNNFFNNRIIAIMNESTEFEER---SATISKEWEQDLKSLKEKNEKLFKNYQT 2348
Query: 886 LH-NRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYES 944
L + A +V + ++ V + TE+ +RE LE + E + ES
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK--IRE----LENSLHEAKESAMHKES 2402
Query: 945 QISSM-----------AKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQ 993
+I M AK +++ E + E K T+ + L K+ G +
Sbjct: 2403 KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETI-------QVLQDKVALGAKPYKE 2455
Query: 994 QLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE 1053
++ ++L+ + V ++LE +K+ + +K++S + TV+ + ++ R+ + +
Sbjct: 2456 EI--EDLKMKLVKIDLEKMKNAKE-FEKEISATKATVEYQKEVIRLLRE---NLRRSQQA 2509
Query: 1054 KDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQE 1113
+DT + S LT + K L++++ L+++IS + + E+ I++
Sbjct: 2510 QDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQ 2569
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 151 bits (382), Expect = 3e-36
Identities = 219/1036 (21%), Positives = 435/1036 (41%), Gaps = 87/1036 (8%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
+K+ ++ E L + + + K + E + ++ + E + +NN+L E R
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE----R 1001
Query: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
+ ++ + +L T+L + + +L L N++ + LE K + + Q+L++
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 154 VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213
++ + Q ++ + E D IA A +I+EL+ +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-ALKKIRELEGHI 1120
Query: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273
LQE L + KQ E+E L L+ +L+S T ++L A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-------TLDS-TATQQELRAKR 1172
Query: 274 NIQVDFLQQA-NKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERH 332
+V L++A +++ ++ E ++ V L+ + E+ + +D+ Q LE+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 333 KEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDEL-LVKSD 391
++ + LG+AK+E++ K + LE + +LQ + + ++ + L+D++ ++++
Sbjct: 1233 NADLAGEL-RVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIE 451
+E+V L + + + K + A QL E ++ E R + T L+ +E
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE------TRQKLNVSTKLRQLE 1342
Query: 452 EER----DYYKKELERLQHI---IQRRSCSTSYSAREKSSIFRTPE-----KGDYNSEIH 499
EER D +E+E Q++ I + S S ++ T E K + EI
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+T++ +E ++ EK +Q + L + D L + +++ RK
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ---RKFDQLLAE 1459
Query: 560 PHNIVSLMEKEKELALSDLR----RIMAEKEALREKLEHIEEVSLFGK---SELEKTIEH 612
NI S E++ A ++ R + ++ AL E LE EE+ K +E+E +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 613 LTCVN---HQLESEKYELKSKVLIMKETIESLEN----------KLKVQAQKFSHVAGDS 659
V H+LE K L++++ MK +E LE+ +L+V Q
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 660 SHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD 719
+ E N + QLQR + +Y+ L +R + A A K LE + +L L+ S
Sbjct: 1580 LQARDEQNEEK--RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 720 EEAHVMKKTIGVIDKE-KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSV 778
+ K + + + KDF +E D + + N++KA E+ +
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--------KSLEADL 1689
Query: 779 NQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEIS 838
QL+E L +R R+Q D +EL E S + LQD+ + ++
Sbjct: 1690 MQLQEDLAAAERA----RKQADLEKEELAEELAS---SLSGRNALQDEKRRLEARIAQLE 1742
Query: 839 LELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAH 898
ELE E M RV K + + + +A + Q Q L + ++ K H
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 899 QAEGE-SSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLE 957
+ EG S + + +++ + L E+V E+E +E A + + + + + + ++E
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 958 EELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL----ENVK 1013
+E + E K + +++L +L+ ++ +Q++N+ + +R + E E +
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEE-ESQRINANRRKLQRELDEATESNEAMG 1918
Query: 1014 SESDLLKKQLSNERHT 1029
E + LK +L T
Sbjct: 1919 REVNALKSKLRRGNET 1934
Score = 146 bits (368), Expect = 1e-34
Identities = 203/1081 (18%), Positives = 464/1081 (42%), Gaps = 115/1081 (10%)
Query: 77 RLSRENNELYL---ELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
+++R+ E+ EL K +E + ELK +K ++ T + L Q + +L +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 134 ESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDP 193
+ + + QE L ++ + R Q++Q + ++ ++
Sbjct: 906 AEEMRVRLAAKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 194 YIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRS 253
LQ+ + ++ +L++++ +M+ SK+ +L E I L+ L
Sbjct: 964 AARQKLQLEK---VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 254 PDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNE 313
+ +NK +E +I+ L +++ +++ ++LEK R+L + S+ +E
Sbjct: 1021 KAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG----------DASDFHE 1069
Query: 314 KLCQELTEIDQLAQQLERHKEEV---LETADKELGE---AKKEIKRKLSEMQDLEETMAK 367
++ +I +L QL + +EE+ L D E+ + A K+I+ + DL+E +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 368 LQLELNLCQKEKERLSDEL-LVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
+ N +K+K L +EL +K++LE + +++ +K+ + V ++ L E
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ ++E R + + +E L +++ + + + K ++
Sbjct: 1190 HEAQ-------------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 487 RTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSN--------------VKLLTAE 532
+ E D E+ + + + E++ ++ E ++++QS V L E
Sbjct: 1231 K--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 533 RDKLSVLYNEAQEELSALRKE----STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEAL 588
+ ++ + NEA+ + L K+ S+Q ++ ++K + LR++ E+ +L
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQ 648
+++L+ E K LE+ H++ +N QL K +L+ T+E+LE K
Sbjct: 1349 QDQLDEEMEA----KQNLER---HISTLNIQLSDSKKKLQD----FASTVEALEEGKKRF 1397
Query: 649 AQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI 708
++ ++ + + L +LQ+ +DD L +R + + + + + K
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKF 1453
Query: 709 DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMK 768
D+L EE ++ K D+ + +E + L+E L KE+ K
Sbjct: 1454 DQLLA------EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 769 IMISECE---SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
++ +E E SS + + + + ++ +L Q++ +L+E+ E+ E+ +L+
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL--EDELQATEDAKLRL 1565
Query: 826 DLATMARENQEISLELEAAVQEKEE----MKSRVHKYITEVS---RWESLMAAKEKENQD 878
++ A + Q +L+A ++ EE ++ ++H+Y TE+ + +L AA +K+
Sbjct: 1566 EVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK--- 1621
Query: 879 LLDRFQMLHNRAEDWEVKAHQA-EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHIN 937
L +D E++A A +G +++ +L + + + + +E E
Sbjct: 1622 -------LEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997
E + S+ + +L+E+L E + + L E SG++ + +
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 998 KNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTE 1057
++ ELE + + + ++ + L + LAT R + + + +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 1058 IQLLKEKLTLSESKLTSQSREN-TMLRAKVAQL--QTDYDALKRQISTERY-ERERAIQE 1113
+ L+ KL E + S+ + L AK+AQL Q + +A ++Q +T+ ++++ ++E
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 1114 M 1114
+
Sbjct: 1854 I 1854
Score = 129 bits (325), Expect = 1e-29
Identities = 212/1043 (20%), Positives = 431/1043 (41%), Gaps = 153/1043 (14%)
Query: 98 QHVKELKTSLKKCARETADLKFLNNQYAH---KLKLL------EKESKAKNERIQQLQEK 148
Q + +K + CA A LK N Q+ K+K L E+E +AK + +Q+ +E+
Sbjct: 811 QQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 149 NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIA-------DLLQV 201
A + +++ ++ + E + +E Y + +A ++L
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYAEAEEMRVRLAAKKQELEEILHE 926
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLES 261
+ R++E + QLQ + M + D +Q+E E ++L + + ++ E+
Sbjct: 927 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--------EKVTAEA 978
Query: 262 RNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL---METKETVTSEVVNLSNKNEKLCQE 318
+ K E I ++ Q + L + K LE+RI +L + +E + L NK+E + E
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 319 LTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLS-EMQDLEETMAKLQ-----LEL 372
L E L+ +K E +K +KRKL + D E +A LQ L++
Sbjct: 1039 L--------------EVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 373 NLCQKEKE------RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
L +KE+E RL DE+ K++ + +LE L + ++S ER + E+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----ERAARNKAEK 1139
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ + G EE + K ELE S +T R K
Sbjct: 1140 QKRDLG-------------------EELEALKTELEDTLD-----STATQQELRAK---- 1171
Query: 487 RTPEKGDYNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQE 545
R E + + TR + ++Q M ++ + +E++ ++ + L ++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231
Query: 546 ELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605
E + L E V +K+ E + +L+ ++ E R +L ++V +
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN--DKVH-----K 1284
Query: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
L+ +E +T + ++ E + +L V + ++ + L+ + ++ +V+ + E
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 666 VNSLRI-------VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEE-------KIDEL 711
NSL+ + L+R + +LS + +L+ + ++ LEE +I+ L
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 712 NLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMI 771
+ + ++KT + +E D L +D + + ++NL++ ++ +A+ K +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 772 SECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMA 831
S+ ++ + ++ + SL R L+ A + +E+ R+ ++ E L +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 832 RENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAE 891
+ E+ A + EEMK+++ + E+ E E Q L +F+
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE------R 1578
Query: 892 DWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK 951
D + + Q E +RR L+ ++ E E+++ Q + A
Sbjct: 1579 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDE-------RKQRALAAA 1617
Query: 952 AMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
A +LE +L+ E + + + RE IK ++L ++ +F+R ELE+
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKG----REEAIK-------QLRKLQAQMKDFQR---ELED 1663
Query: 1012 VKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESK 1071
++ D + K+LE+ L ++ + + D E + L E+L S S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 1072 LTSQSRENTMLRAKVAQLQTDYD 1094
+ E L A++AQL+ + +
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELE 1746
Score = 126 bits (317), Expect = 1e-28
Identities = 179/886 (20%), Positives = 373/886 (42%), Gaps = 144/886 (16%)
Query: 30 LPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLEL 89
L + +L + E L + + KAEK+ + LE K E + +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----LEDTLDSTATQ 1165
Query: 90 MKLREHSDQHVKELKTSLKKCARE-TADLKFLNNQYAHKLKLLE------KESKAKNERI 142
+LR +Q V LK +L + R A ++ + ++A ++ L K +KA ++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 143 QQLQEK---NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLL 199
+Q EK +L ++ G K+ + ++++++ S+ S + + + D +
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKV 1282
Query: 200 QVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIE-----LREREIERLSVA-----LD 249
N ++ + +++ + K + V S Q++ L+E ++L+V+ L+
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 250 GGRSP--DVLSLESRNKTN-EKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVV 306
R+ D L E K N E+ I+ LNIQ+ ++ +D + L E K+ E+
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 307 NLSNKNE--------------KLCQELTEI---------------------DQLAQQLER 331
NL+ + E +L QEL ++ DQL + +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 332 HKEEVLETADKELGEAKKEIKRKLSEMQDLEETM-AKLQLELNLCQKEKERLSDELLVKS 390
+ + D+ EA+++ + LS + LEE + AK +LE + K + D + K
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKD 1521
Query: 391 DLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE-----RMRLEHGIKRRDRSPSRLDT 445
D+ VH+LE+ K+ L ++E +L E++ ++RLE ++ + +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFER 1578
Query: 446 FLKGIEEERDYYKKELERLQHIIQ------RRSCSTSYSAREKSSIFRTPEKGDYNSEIH 499
L+ +E+ + +++L+R H + R+ + + +A++K + D +
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE----GDLKDLELQAD 1634
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+ R+E + L + + M+D Q ++ A RD++ E +++ +L +
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------ 1688
Query: 560 PHNIVSLMEKEKELALSDLRRIMA--EKEALREKLEHIEEVSLFGKSELEKTIEHLTCVN 617
LM+ +++LA ++ R A EKE L E+L SL G++ L+ L
Sbjct: 1689 ------LMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARI 1738
Query: 618 HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQ 677
QLE E E + + E++ ++++ Q+ ++ + + +++ +QL+
Sbjct: 1739 AQLEEELEEEQGNM-------EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 678 RSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKD 737
R Q K L K+ E+ + S+ K TI ++ +
Sbjct: 1792 R---------------------QNKELRSKLHEMEGAVKSK------FKSTIAALEAKIA 1824
Query: 738 FLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRR 797
L+E V+++ + ++L K+K + ++ + + + Q KE + + L+R
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 798 QLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEA 843
QL+ A +E + +R R+LQ +L N+ + E+ A
Sbjct: 1885 QLEEAEEESQRINANR-------RKLQRELDEATESNEAMGREVNA 1923
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 151 bits (382), Expect = 3e-36
Identities = 219/1036 (21%), Positives = 435/1036 (41%), Gaps = 87/1036 (8%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
+K+ ++ E L + + + K + E + ++ + E + +NN+L E R
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE----R 1008
Query: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
+ ++ + +L T+L + + +L L N++ + LE K + + Q+L++
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 154 VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213
++ + Q ++ + E D IA A +I+EL+ +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-ALKKIRELEGHI 1127
Query: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273
LQE L + KQ E+E L L+ +L+S T ++L A
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-------TLDS-TATQQELRAKR 1179
Query: 274 NIQVDFLQQA-NKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERH 332
+V L++A +++ ++ E ++ V L+ + E+ + +D+ Q LE+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 333 KEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDEL-LVKSD 391
++ + LG+AK+E++ K + LE + +LQ + + ++ + L+D++ ++++
Sbjct: 1240 NADLAGEL-RVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIE 451
+E+V L + + + K + A QL E ++ E R + T L+ +E
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE------TRQKLNVSTKLRQLE 1349
Query: 452 EER----DYYKKELERLQHI---IQRRSCSTSYSAREKSSIFRTPE-----KGDYNSEIH 499
EER D +E+E Q++ I + S S ++ T E K + EI
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+T++ +E ++ EK +Q + L + D L + +++ RK
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ---RKFDQLLAE 1466
Query: 560 PHNIVSLMEKEKELALSDLR----RIMAEKEALREKLEHIEEVSLFGK---SELEKTIEH 612
NI S E++ A ++ R + ++ AL E LE EE+ K +E+E +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 613 LTCVN---HQLESEKYELKSKVLIMKETIESLEN----------KLKVQAQKFSHVAGDS 659
V H+LE K L++++ MK +E LE+ +L+V Q
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 660 SHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD 719
+ E N + QLQR + +Y+ L +R + A A K LE + +L L+ S
Sbjct: 1587 LQARDEQNEEK--RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 720 EEAHVMKKTIGVIDKE-KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSV 778
+ K + + + KDF +E D + + N++KA E+ +
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--------KSLEADL 1696
Query: 779 NQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEIS 838
QL+E L +R R+Q D +EL E S + LQD+ + ++
Sbjct: 1697 MQLQEDLAAAERA----RKQADLEKEELAEELAS---SLSGRNALQDEKRRLEARIAQLE 1749
Query: 839 LELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAH 898
ELE E M RV K + + + +A + Q Q L + ++ K H
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 899 QAEGE-SSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLE 957
+ EG S + + +++ + L E+V E+E +E A + + + + + + ++E
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 958 EELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVEL----ENVK 1013
+E + E K + +++L +L+ ++ +Q++N+ + +R + E E +
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEE-ESQRINANRRKLQRELDEATESNEAMG 1925
Query: 1014 SESDLLKKQLSNERHT 1029
E + LK +L T
Sbjct: 1926 REVNALKSKLRRGNET 1941
Score = 146 bits (368), Expect = 1e-34
Identities = 203/1081 (18%), Positives = 464/1081 (42%), Gaps = 115/1081 (10%)
Query: 77 RLSRENNELYL---ELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
+++R+ E+ EL K +E + ELK +K ++ T + L Q + +L +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 134 ESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDP 193
+ + + QE L ++ + R Q++Q + ++ ++
Sbjct: 913 AEEMRVRLAAKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 194 YIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRS 253
LQ+ + ++ +L++++ +M+ SK+ +L E I L+ L
Sbjct: 971 AARQKLQLEK---VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 254 PDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNE 313
+ +NK +E +I+ L +++ +++ ++LEK R+L + S+ +E
Sbjct: 1028 KAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG----------DASDFHE 1076
Query: 314 KLCQELTEIDQLAQQLERHKEEV---LETADKELGE---AKKEIKRKLSEMQDLEETMAK 367
++ +I +L QL + +EE+ L D E+ + A K+I+ + DL+E +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 368 LQLELNLCQKEKERLSDEL-LVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
+ N +K+K L +EL +K++LE + +++ +K+ + V ++ L E
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ ++E R + + +E L +++ + + + K ++
Sbjct: 1197 HEAQ-------------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 487 RTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSN--------------VKLLTAE 532
+ E D E+ + + + E++ ++ E ++++QS V L E
Sbjct: 1238 K--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 533 RDKLSVLYNEAQEELSALRKE----STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEAL 588
+ ++ + NEA+ + L K+ S+Q ++ ++K + LR++ E+ +L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQ 648
+++L+ E K LE+ H++ +N QL K +L+ T+E+LE K
Sbjct: 1356 QDQLDEEMEA----KQNLER---HISTLNIQLSDSKKKLQD----FASTVEALEEGKKRF 1404
Query: 649 AQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI 708
++ ++ + + L +LQ+ +DD L +R + + + + + K
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKF 1460
Query: 709 DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMK 768
D+L EE ++ K D+ + +E + L+E L KE+ K
Sbjct: 1461 DQLLA------EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 769 IMISECE---SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
++ +E E SS + + + + ++ +L Q++ +L+E+ E+ E+ +L+
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL--EDELQATEDAKLRL 1572
Query: 826 DLATMARENQEISLELEAAVQEKEE----MKSRVHKYITEVS---RWESLMAAKEKENQD 878
++ A + Q +L+A ++ EE ++ ++H+Y TE+ + +L AA +K+
Sbjct: 1573 EVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK--- 1628
Query: 879 LLDRFQMLHNRAEDWEVKAHQA-EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHIN 937
L +D E++A A +G +++ +L + + + + +E E
Sbjct: 1629 -------LEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997
E + S+ + +L+E+L E + + L E SG++ + +
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 998 KNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTE 1057
++ ELE + + + ++ + L + LAT R + + + +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 1058 IQLLKEKLTLSESKLTSQSREN-TMLRAKVAQL--QTDYDALKRQISTERY-ERERAIQE 1113
+ L+ KL E + S+ + L AK+AQL Q + +A ++Q +T+ ++++ ++E
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 1114 M 1114
+
Sbjct: 1861 I 1861
Score = 129 bits (325), Expect = 1e-29
Identities = 212/1043 (20%), Positives = 431/1043 (41%), Gaps = 153/1043 (14%)
Query: 98 QHVKELKTSLKKCARETADLKFLNNQYAH---KLKLL------EKESKAKNERIQQLQEK 148
Q + +K + CA A LK N Q+ K+K L E+E +AK + +Q+ +E+
Sbjct: 818 QQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 149 NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIA-------DLLQV 201
A + +++ ++ + E + +E Y + +A ++L
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYAEAEEMRVRLAAKKQELEEILHE 933
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLES 261
+ R++E + QLQ + M + D +Q+E E ++L + + ++ E+
Sbjct: 934 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--------EKVTAEA 985
Query: 262 RNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL---METKETVTSEVVNLSNKNEKLCQE 318
+ K E I ++ Q + L + K LE+RI +L + +E + L NK+E + E
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 319 LTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLS-EMQDLEETMAKLQ-----LEL 372
L E L+ +K E +K +KRKL + D E +A LQ L++
Sbjct: 1046 L--------------EVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 373 NLCQKEKE------RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
L +KE+E RL DE+ K++ + +LE L + ++S ER + E+
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----ERAARNKAEK 1146
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ + G EE + K ELE S +T R K
Sbjct: 1147 QKRDLG-------------------EELEALKTELEDTLD-----STATQQELRAK---- 1178
Query: 487 RTPEKGDYNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQE 545
R E + + TR + ++Q M ++ + +E++ ++ + L ++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238
Query: 546 ELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605
E + L E V +K+ E + +L+ ++ E R +L ++V +
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN--DKVH-----K 1291
Query: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
L+ +E +T + ++ E + +L V + ++ + L+ + ++ +V+ + E
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 666 VNSLRI-------VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEE-------KIDEL 711
NSL+ + L+R + +LS + +L+ + ++ LEE +I+ L
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 712 NLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMI 771
+ + ++KT + +E D L +D + + ++NL++ ++ +A+ K +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 772 SECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMA 831
S+ ++ + ++ + SL R L+ A + +E+ R+ ++ E L +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 832 RENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAE 891
+ E+ A + EEMK+++ + E+ E E Q L +F+
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE------R 1585
Query: 892 DWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK 951
D + + Q E +RR L+ ++ E E+++ Q + A
Sbjct: 1586 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDE-------RKQRALAAA 1624
Query: 952 AMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
A +LE +L+ E + + + RE IK ++L ++ +F+R ELE+
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKG----REEAIK-------QLRKLQAQMKDFQR---ELED 1670
Query: 1012 VKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESK 1071
++ D + K+LE+ L ++ + + D E + L E+L S S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 1072 LTSQSRENTMLRAKVAQLQTDYD 1094
+ E L A++AQL+ + +
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELE 1753
Score = 126 bits (317), Expect = 1e-28
Identities = 179/886 (20%), Positives = 373/886 (42%), Gaps = 144/886 (16%)
Query: 30 LPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLEL 89
L + +L + E L + + KAEK+ + LE K E + +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----LEDTLDSTATQ 1172
Query: 90 MKLREHSDQHVKELKTSLKKCARE-TADLKFLNNQYAHKLKLLE------KESKAKNERI 142
+LR +Q V LK +L + R A ++ + ++A ++ L K +KA ++
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 143 QQLQEK---NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLL 199
+Q EK +L ++ G K+ + ++++++ S+ S + + + D +
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKV 1289
Query: 200 QVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIE-----LREREIERLSVA-----LD 249
N ++ + +++ + K + V S Q++ L+E ++L+V+ L+
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 250 GGRSP--DVLSLESRNKTN-EKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVV 306
R+ D L E K N E+ I+ LNIQ+ ++ +D + L E K+ E+
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 307 NLSNKNE--------------KLCQELTEI---------------------DQLAQQLER 331
NL+ + E +L QEL ++ DQL + +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 332 HKEEVLETADKELGEAKKEIKRKLSEMQDLEETM-AKLQLELNLCQKEKERLSDELLVKS 390
+ + D+ EA+++ + LS + LEE + AK +LE + K + D + K
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKD 1528
Query: 391 DLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE-----RMRLEHGIKRRDRSPSRLDT 445
D+ VH+LE+ K+ L ++E +L E++ ++RLE ++ + +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFER 1585
Query: 446 FLKGIEEERDYYKKELERLQHIIQ------RRSCSTSYSAREKSSIFRTPEKGDYNSEIH 499
L+ +E+ + +++L+R H + R+ + + +A++K + D +
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE----GDLKDLELQAD 1641
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+ R+E + L + + M+D Q ++ A RD++ E +++ +L +
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------ 1695
Query: 560 PHNIVSLMEKEKELALSDLRRIMA--EKEALREKLEHIEEVSLFGKSELEKTIEHLTCVN 617
LM+ +++LA ++ R A EKE L E+L SL G++ L+ L
Sbjct: 1696 ------LMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARI 1745
Query: 618 HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQ 677
QLE E E + + E++ ++++ Q+ ++ + + +++ +QL+
Sbjct: 1746 AQLEEELEEEQGNM-------EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 678 RSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKD 737
R Q K L K+ E+ + S+ K TI ++ +
Sbjct: 1799 R---------------------QNKELRSKLHEMEGAVKSK------FKSTIAALEAKIA 1831
Query: 738 FLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRR 797
L+E V+++ + ++L K+K + ++ + + + Q KE + + L+R
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 798 QLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEA 843
QL+ A +E + +R R+LQ +L N+ + E+ A
Sbjct: 1892 QLEEAEEESQRINANR-------RKLQRELDEATESNEAMGREVNA 1930
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 151 bits (381), Expect = 4e-36
Identities = 214/1027 (20%), Positives = 434/1027 (42%), Gaps = 86/1027 (8%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
+K+ ++ E L + + + K + E + ++ + E + +NN+L E R
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE----R 1008
Query: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
+ ++ + +L T+L + + +L L N++ + LE K + + Q+L++
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 154 VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213
++ + Q ++ + E D IA A +I+EL+ +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-ALKKIRELEGHI 1127
Query: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273
LQE L + KQ E+E L L+ +L+S T ++L A
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-------TLDS-TATQQELRAKR 1179
Query: 274 NIQVDFLQQA-NKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERH 332
+V L++A +++ ++ E ++ V L+ + E+ + +D+ Q LE+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 333 KEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDEL-LVKSD 391
++ + LG+AK+E++ K + LE + +LQ + + ++ + L+D++ ++++
Sbjct: 1240 NADLAGEL-RVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIE 451
+E+V L + + + K + A QL E ++ E R + T L+ +E
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE------TRQKLNVSTKLRQLE 1349
Query: 452 EER----DYYKKELERLQHI---IQRRSCSTSYSAREKSSIFRTPE-----KGDYNSEIH 499
EER D +E+E Q++ I + S S ++ T E K + EI
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+T++ +E ++ EK +Q + L + D L + +++ RK
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ---RKFDQLLAE 1466
Query: 560 PHNIVSLMEKEKELALSDLR----RIMAEKEALREKLEHIEEVSLFGK---SELEKTIEH 612
NI S E++ A ++ R + ++ AL E LE EE+ K +E+E +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 613 LTCVN---HQLESEKYELKSKVLIMKETIESLEN----------KLKVQAQKFSHVAGDS 659
V H+LE K L++++ MK +E LE+ +L+V Q
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 660 SHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD 719
+ E N + QLQR + +Y+ L +R + A A K LE + +L L+ S
Sbjct: 1587 LQARDEQNEEK--RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 720 EEAHVMKKTIGVIDKE-KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSV 778
+ K + + + KDF +E D + + N++KA E+ +
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--------KSLEADL 1696
Query: 779 NQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEIS 838
QL+E L +R R+Q D +EL E S + LQD+ + ++
Sbjct: 1697 MQLQEDLAAAERA----RKQADLEKEELAEELAS---SLSGRNALQDEKRRLEARIAQLE 1749
Query: 839 LELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAH 898
ELE E M RV K + + + +A + Q Q L + ++ K H
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 899 QAEGE-SSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLE 957
+ EG S + + +++ + L E+V E+E +E A + + + + + + ++E
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 958 EELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESD 1017
+E + E K + +++L +L+ ++ +Q++N+ + +R EL+ ++
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEE-ESQRINANRRKLQR---ELDEATESNE 1922
Query: 1018 LLKKQLS 1024
+ ++++
Sbjct: 1923 AMGREVN 1929
Score = 146 bits (368), Expect = 1e-34
Identities = 203/1081 (18%), Positives = 464/1081 (42%), Gaps = 115/1081 (10%)
Query: 77 RLSRENNELYL---ELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
+++R+ E+ EL K +E + ELK +K ++ T + L Q + +L +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 134 ESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDP 193
+ + + QE L ++ + R Q++Q + ++ ++
Sbjct: 913 AEEMRVRLAAKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 194 YIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRS 253
LQ+ + ++ +L++++ +M+ SK+ +L E I L+ L
Sbjct: 971 AARQKLQLEK---VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 254 PDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNE 313
+ +NK +E +I+ L +++ +++ ++LEK R+L + S+ +E
Sbjct: 1028 KAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG----------DASDFHE 1076
Query: 314 KLCQELTEIDQLAQQLERHKEEV---LETADKELGE---AKKEIKRKLSEMQDLEETMAK 367
++ +I +L QL + +EE+ L D E+ + A K+I+ + DL+E +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 368 LQLELNLCQKEKERLSDEL-LVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
+ N +K+K L +EL +K++LE + +++ +K+ + V ++ L E
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ ++E R + + +E L +++ + + + K ++
Sbjct: 1197 HEAQ-------------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 487 RTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSN--------------VKLLTAE 532
+ E D E+ + + + E++ ++ E ++++QS V L E
Sbjct: 1238 K--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 533 RDKLSVLYNEAQEELSALRKE----STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEAL 588
+ ++ + NEA+ + L K+ S+Q ++ ++K + LR++ E+ +L
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQ 648
+++L+ E K LE+ H++ +N QL K +L+ T+E+LE K
Sbjct: 1356 QDQLDEEMEA----KQNLER---HISTLNIQLSDSKKKLQD----FASTVEALEEGKKRF 1404
Query: 649 AQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI 708
++ ++ + + L +LQ+ +DD L +R + + + + + K
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKF 1460
Query: 709 DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMK 768
D+L EE ++ K D+ + +E + L+E L KE+ K
Sbjct: 1461 DQLLA------EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 769 IMISECE---SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
++ +E E SS + + + + ++ +L Q++ +L+E+ E+ E+ +L+
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL--EDELQATEDAKLRL 1572
Query: 826 DLATMARENQEISLELEAAVQEKEE----MKSRVHKYITEVS---RWESLMAAKEKENQD 878
++ A + Q +L+A ++ EE ++ ++H+Y TE+ + +L AA +K+
Sbjct: 1573 EVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK--- 1628
Query: 879 LLDRFQMLHNRAEDWEVKAHQA-EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHIN 937
L +D E++A A +G +++ +L + + + + +E E
Sbjct: 1629 -------LEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997
E + S+ + +L+E+L E + + L E SG++ + +
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 998 KNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTE 1057
++ ELE + + + ++ + L + LAT R + + + +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 1058 IQLLKEKLTLSESKLTSQSREN-TMLRAKVAQL--QTDYDALKRQISTERY-ERERAIQE 1113
+ L+ KL E + S+ + L AK+AQL Q + +A ++Q +T+ ++++ ++E
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 1114 M 1114
+
Sbjct: 1861 I 1861
Score = 129 bits (325), Expect = 1e-29
Identities = 212/1043 (20%), Positives = 431/1043 (41%), Gaps = 153/1043 (14%)
Query: 98 QHVKELKTSLKKCARETADLKFLNNQYAH---KLKLL------EKESKAKNERIQQLQEK 148
Q + +K + CA A LK N Q+ K+K L E+E +AK + +Q+ +E+
Sbjct: 818 QQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 149 NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIA-------DLLQV 201
A + +++ ++ + E + +E Y + +A ++L
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYAEAEEMRVRLAAKKQELEEILHE 933
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLES 261
+ R++E + QLQ + M + D +Q+E E ++L + + ++ E+
Sbjct: 934 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--------EKVTAEA 985
Query: 262 RNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL---METKETVTSEVVNLSNKNEKLCQE 318
+ K E I ++ Q + L + K LE+RI +L + +E + L NK+E + E
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 319 LTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLS-EMQDLEETMAKLQ-----LEL 372
L E L+ +K E +K +KRKL + D E +A LQ L++
Sbjct: 1046 L--------------EVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 373 NLCQKEKE------RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
L +KE+E RL DE+ K++ + +LE L + ++S ER + E+
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----ERAARNKAEK 1146
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ + G EE + K ELE S +T R K
Sbjct: 1147 QKRDLG-------------------EELEALKTELEDTLD-----STATQQELRAK---- 1178
Query: 487 RTPEKGDYNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQE 545
R E + + TR + ++Q M ++ + +E++ ++ + L ++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238
Query: 546 ELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605
E + L E V +K+ E + +L+ ++ E R +L ++V +
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN--DKVH-----K 1291
Query: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
L+ +E +T + ++ E + +L V + ++ + L+ + ++ +V+ + E
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 666 VNSLRI-------VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEE-------KIDEL 711
NSL+ + L+R + +LS + +L+ + ++ LEE +I+ L
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 712 NLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMI 771
+ + ++KT + +E D L +D + + ++NL++ ++ +A+ K +
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 772 SECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMA 831
S+ ++ + ++ + SL R L+ A + +E+ R+ ++ E L +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 832 RENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAE 891
+ E+ A + EEMK+++ + E+ E E Q L +F+
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE------R 1585
Query: 892 DWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK 951
D + + Q E +RR L+ ++ E E+++ Q + A
Sbjct: 1586 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDE-------RKQRALAAA 1624
Query: 952 AMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
A +LE +L+ E + + + RE IK ++L ++ +F+R ELE+
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKG----REEAIK-------QLRKLQAQMKDFQR---ELED 1670
Query: 1012 VKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESK 1071
++ D + K+LE+ L ++ + + D E + L E+L S S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 1072 LTSQSRENTMLRAKVAQLQTDYD 1094
+ E L A++AQL+ + +
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELE 1753
Score = 129 bits (324), Expect = 2e-29
Identities = 188/873 (21%), Positives = 376/873 (43%), Gaps = 129/873 (14%)
Query: 30 LPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLEL 89
L + +L + E L + + KAEK+ + LE K E + +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----LEDTLDSTATQ 1172
Query: 90 MKLREHSDQHVKELKTSLKKCARE-TADLKFLNNQYAHKLKLLE------KESKAKNERI 142
+LR +Q V LK +L + R A ++ + ++A ++ L K +KA ++
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 143 QQLQEK---NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLL 199
+Q EK +L ++ G K+ + ++++++ S+ S + + + D +
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKV 1289
Query: 200 QVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIE-----LREREIERLSVA-----LD 249
N ++ + +++ + K + V S Q++ L+E ++L+V+ L+
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1349
Query: 250 GGRSP--DVLSLESRNKTN-EKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVV 306
R+ D L E K N E+ I+ LNIQ+ ++ +D + L E K+ E+
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 307 NLSNKNE--------------KLCQELTEI---------------------DQLAQQLER 331
NL+ + E +L QEL ++ DQL + +
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 332 HKEEVLETADKELGEAKKEIKRKLSEMQDLEETM-AKLQLELNLCQKEKERLSDELLVKS 390
+ + D+ EA+++ + LS + LEE + AK +LE + K + D + K
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKD 1528
Query: 391 DLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE-----RMRLEHGIKRRDRSPSRLDT 445
D+ VH+LE+ K+ L ++E +L E++ ++RLE ++ + +
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFER 1585
Query: 446 FLKGIEEERDYYKKELERLQHIIQ------RRSCSTSYSAREKSSIFRTPEKGDYNSEIH 499
L+ +E+ + +++L+R H + R+ + + +A++K + D +
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE----GDLKDLELQAD 1641
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+ R+E + L + + M+D Q ++ A RD++ E +++ +L +
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------ 1695
Query: 560 PHNIVSLMEKEKELALSDLRRIMA--EKEALREKLEHIEEVSLFGKSELEKTIEHLTCVN 617
LM+ +++LA ++ R A EKE L E+L SL G++ L+ L
Sbjct: 1696 ------LMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARI 1745
Query: 618 HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQ 677
QLE E E + + E++ ++++ Q+ ++ + + +++ +QL+
Sbjct: 1746 AQLEEELEEEQGNM-------EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 678 RSVDDYQHRLSIKRGELESA-QAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKE- 735
R + + +L G ++S ++ I LE KI +L ++ + E K++ DK+
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 736 KDFLQETVDEKTEKIANLQENLANKEKA-VAQMKIMISECESSVNQLKETLVNRDREINS 794
K+ L + DE+ K+A + A K A V Q+K + E E + IN+
Sbjct: 1859 KEILLQVEDER--KMAEQYKEQAEKGNARVKQLKRQLEEAEEE-----------SQRINA 1905
Query: 795 LRRQLDAAHKELDEVGRSREIAFKENRRLQDDL 827
RR+L +ELDE S E +E L+ L
Sbjct: 1906 NRRKLQ---RELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 151 bits (381), Expect = 4e-36
Identities = 214/1027 (20%), Positives = 434/1027 (42%), Gaps = 86/1027 (8%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
+K+ ++ E L + + + K + E + ++ + E + +NN+L E R
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE----R 1001
Query: 94 EHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAV 153
+ ++ + +L T+L + + +L L N++ + LE K + + Q+L++
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 154 VQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV 213
++ + Q ++ + E D IA A +I+EL+ +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN-ALKKIRELEGHI 1120
Query: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHL 273
LQE L + KQ E+E L L+ +L+S T ++L A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-------TLDS-TATQQELRAKR 1172
Query: 274 NIQVDFLQQA-NKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERH 332
+V L++A +++ ++ E ++ V L+ + E+ + +D+ Q LE+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 333 KEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDEL-LVKSD 391
++ + LG+AK+E++ K + LE + +LQ + + ++ + L+D++ ++++
Sbjct: 1233 NADLAGEL-RVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIE 451
+E+V L + + + K + A QL E ++ E R + T L+ +E
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE------TRQKLNVSTKLRQLE 1342
Query: 452 EER----DYYKKELERLQHI---IQRRSCSTSYSAREKSSIFRTPE-----KGDYNSEIH 499
EER D +E+E Q++ I + S S ++ T E K + EI
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+T++ +E ++ EK +Q + L + D L + +++ RK
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ---RKFDQLLAE 1459
Query: 560 PHNIVSLMEKEKELALSDLR----RIMAEKEALREKLEHIEEVSLFGK---SELEKTIEH 612
NI S E++ A ++ R + ++ AL E LE EE+ K +E+E +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 613 LTCVN---HQLESEKYELKSKVLIMKETIESLEN----------KLKVQAQKFSHVAGDS 659
V H+LE K L++++ MK +E LE+ +L+V Q
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 660 SHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQD 719
+ E N + QLQR + +Y+ L +R + A A K LE + +L L+ S
Sbjct: 1580 LQARDEQNEEK--RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 720 EEAHVMKKTIGVIDKE-KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSV 778
+ K + + + KDF +E D + + N++KA E+ +
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--------KSLEADL 1689
Query: 779 NQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEIS 838
QL+E L +R R+Q D +EL E S + LQD+ + ++
Sbjct: 1690 MQLQEDLAAAERA----RKQADLEKEELAEELAS---SLSGRNALQDEKRRLEARIAQLE 1742
Query: 839 LELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAH 898
ELE E M RV K + + + +A + Q Q L + ++ K H
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 899 QAEGE-SSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLE 957
+ EG S + + +++ + L E+V E+E +E A + + + + + + ++E
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 958 EELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESD 1017
+E + E K + +++L +L+ ++ +Q++N+ + +R EL+ ++
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEE-ESQRINANRRKLQR---ELDEATESNE 1915
Query: 1018 LLKKQLS 1024
+ ++++
Sbjct: 1916 AMGREVN 1922
Score = 146 bits (368), Expect = 1e-34
Identities = 203/1081 (18%), Positives = 464/1081 (42%), Gaps = 115/1081 (10%)
Query: 77 RLSRENNELYL---ELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
+++R+ E+ EL K +E + ELK +K ++ T + L Q + +L +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 134 ESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDP 193
+ + + QE L ++ + R Q++Q + ++ ++
Sbjct: 906 AEEMRVRLAAKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 194 YIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRS 253
LQ+ + ++ +L++++ +M+ SK+ +L E I L+ L
Sbjct: 964 AARQKLQLEK---VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 254 PDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNE 313
+ +NK +E +I+ L +++ +++ ++LEK R+L + S+ +E
Sbjct: 1021 KAKNLTKLKNK-HESMISELEVRLKKEEKSRQELEKLKRKLEG----------DASDFHE 1069
Query: 314 KLCQELTEIDQLAQQLERHKEEV---LETADKELGE---AKKEIKRKLSEMQDLEETMAK 367
++ +I +L QL + +EE+ L D E+ + A K+I+ + DL+E +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 368 LQLELNLCQKEKERLSDEL-LVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
+ N +K+K L +EL +K++LE + +++ +K+ + V ++ L E
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ ++E R + + +E L +++ + + + K ++
Sbjct: 1190 HEAQ-------------------VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 487 RTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSN--------------VKLLTAE 532
+ E D E+ + + + E++ ++ E ++++QS V L E
Sbjct: 1231 K--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 533 RDKLSVLYNEAQEELSALRKE----STQTTAPHNIVSLMEKEKELALSDLRRIMAEKEAL 588
+ ++ + NEA+ + L K+ S+Q ++ ++K + LR++ E+ +L
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQ 648
+++L+ E K LE+ H++ +N QL K +L+ T+E+LE K
Sbjct: 1349 QDQLDEEMEA----KQNLER---HISTLNIQLSDSKKKLQD----FASTVEALEEGKKRF 1397
Query: 649 AQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI 708
++ ++ + + L +LQ+ +DD L +R + + + + + K
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKF 1453
Query: 709 DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMK 768
D+L EE ++ K D+ + +E + L+E L KE+ K
Sbjct: 1454 DQLLA------EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 769 IMISECE---SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
++ +E E SS + + + + ++ +L Q++ +L+E+ E+ E+ +L+
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL--EDELQATEDAKLRL 1565
Query: 826 DLATMARENQEISLELEAAVQEKEE----MKSRVHKYITEVS---RWESLMAAKEKENQD 878
++ A + Q +L+A ++ EE ++ ++H+Y TE+ + +L AA +K+
Sbjct: 1566 EVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK--- 1621
Query: 879 LLDRFQMLHNRAEDWEVKAHQA-EGESSSVRLELLSIDTERRHLRERVELLEKEIQEHIN 937
L +D E++A A +G +++ +L + + + + +E E
Sbjct: 1622 -------LEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNS 997
E + S+ + +L+E+L E + + L E SG++ + +
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 998 KNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTE 1057
++ ELE + + + ++ + L + LAT R + + + +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 1058 IQLLKEKLTLSESKLTSQSREN-TMLRAKVAQL--QTDYDALKRQISTERY-ERERAIQE 1113
+ L+ KL E + S+ + L AK+AQL Q + +A ++Q +T+ ++++ ++E
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 1114 M 1114
+
Sbjct: 1854 I 1854
Score = 129 bits (325), Expect = 1e-29
Identities = 212/1043 (20%), Positives = 431/1043 (41%), Gaps = 153/1043 (14%)
Query: 98 QHVKELKTSLKKCARETADLKFLNNQYAH---KLKLL------EKESKAKNERIQQLQEK 148
Q + +K + CA A LK N Q+ K+K L E+E +AK + +Q+ +E+
Sbjct: 811 QQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 149 NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIA-------DLLQV 201
A + +++ ++ + E + +E Y + +A ++L
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQ-AETELYAEAEEMRVRLAAKKQELEEILHE 926
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLES 261
+ R++E + QLQ + M + D +Q+E E ++L + + ++ E+
Sbjct: 927 MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL--------EKVTAEA 978
Query: 262 RNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL---METKETVTSEVVNLSNKNEKLCQE 318
+ K E I ++ Q + L + K LE+RI +L + +E + L NK+E + E
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 319 LTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLS-EMQDLEETMAKLQ-----LEL 372
L E L+ +K E +K +KRKL + D E +A LQ L++
Sbjct: 1039 L--------------EVRLKKEEKSRQELEK-LKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 373 NLCQKEKE------RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER 426
L +KE+E RL DE+ K++ + +LE L + ++S ER + E+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS----ERAARNKAEK 1139
Query: 427 MRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIF 486
+ + G EE + K ELE S +T R K
Sbjct: 1140 QKRDLG-------------------EELEALKTELEDTLD-----STATQQELRAK---- 1171
Query: 487 RTPEKGDYNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQE 545
R E + + TR + ++Q M ++ + +E++ ++ + L ++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231
Query: 546 ELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSE 605
E + L E V +K+ E + +L+ ++ E R +L ++V +
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN--DKVH-----K 1284
Query: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
L+ +E +T + ++ E + +L V + ++ + L+ + ++ +V+ + E
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 666 VNSLRI-------VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEE-------KIDEL 711
NSL+ + L+R + +LS + +L+ + ++ LEE +I+ L
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 712 NLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMI 771
+ + ++KT + +E D L +D + + ++NL++ ++ +A+ K +
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 772 SECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMA 831
S+ ++ + ++ + SL R L+ A + +E+ R+ ++ E L +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 832 RENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAE 891
+ E+ A + EEMK+++ + E+ E E Q L +F+
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE------R 1578
Query: 892 DWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK 951
D + + Q E +RR L+ ++ E E+++ Q + A
Sbjct: 1579 DLQARDEQNE--------------EKRRQLQRQLHEYETELEDE-------RKQRALAAA 1617
Query: 952 AMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
A +LE +L+ E + + + RE IK ++L ++ +F+R ELE+
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKG----REEAIK-------QLRKLQAQMKDFQR---ELED 1663
Query: 1012 VKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESK 1071
++ D + K+LE+ L ++ + + D E + L E+L S S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 1072 LTSQSRENTMLRAKVAQLQTDYD 1094
+ E L A++AQL+ + +
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELE 1746
Score = 129 bits (324), Expect = 2e-29
Identities = 188/873 (21%), Positives = 376/873 (43%), Gaps = 129/873 (14%)
Query: 30 LPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLEL 89
L + +L + E L + + KAEK+ + LE K E + +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----LEDTLDSTATQ 1165
Query: 90 MKLREHSDQHVKELKTSLKKCARE-TADLKFLNNQYAHKLKLLE------KESKAKNERI 142
+LR +Q V LK +L + R A ++ + ++A ++ L K +KA ++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 143 QQLQEK---NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLL 199
+Q EK +L ++ G K+ + ++++++ S+ S + + + D +
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKV 1282
Query: 200 QVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIE-----LREREIERLSVA-----LD 249
N ++ + +++ + K + V S Q++ L+E ++L+V+ L+
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE 1342
Query: 250 GGRSP--DVLSLESRNKTN-EKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVV 306
R+ D L E K N E+ I+ LNIQ+ ++ +D + L E K+ E+
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 307 NLSNKNE--------------KLCQELTEI---------------------DQLAQQLER 331
NL+ + E +L QEL ++ DQL + +
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 332 HKEEVLETADKELGEAKKEIKRKLSEMQDLEETM-AKLQLELNLCQKEKERLSDELLVKS 390
+ + D+ EA+++ + LS + LEE + AK +LE + K + D + K
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKD 1521
Query: 391 DLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE-----RMRLEHGIKRRDRSPSRLDT 445
D+ VH+LE+ K+ L ++E +L E++ ++RLE ++ + +
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFER 1578
Query: 446 FLKGIEEERDYYKKELERLQHIIQ------RRSCSTSYSAREKSSIFRTPEKGDYNSEIH 499
L+ +E+ + +++L+R H + R+ + + +A++K + D +
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE----GDLKDLELQAD 1634
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+ R+E + L + + M+D Q ++ A RD++ E +++ +L +
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------ 1688
Query: 560 PHNIVSLMEKEKELALSDLRRIMA--EKEALREKLEHIEEVSLFGKSELEKTIEHLTCVN 617
LM+ +++LA ++ R A EKE L E+L SL G++ L+ L
Sbjct: 1689 ------LMQLQEDLAAAERARKQADLEKEELAEELAS----SLSGRNALQDEKRRLEARI 1738
Query: 618 HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQ 677
QLE E E + + E++ ++++ Q+ ++ + + +++ +QL+
Sbjct: 1739 AQLEEELEEEQGNM-------EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 678 RSVDDYQHRLSIKRGELESA-QAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKE- 735
R + + +L G ++S ++ I LE KI +L ++ + E K++ DK+
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 736 KDFLQETVDEKTEKIANLQENLANKEKA-VAQMKIMISECESSVNQLKETLVNRDREINS 794
K+ L + DE+ K+A + A K A V Q+K + E E + IN+
Sbjct: 1852 KEILLQVEDER--KMAEQYKEQAEKGNARVKQLKRQLEEAEEE-----------SQRINA 1898
Query: 795 LRRQLDAAHKELDEVGRSREIAFKENRRLQDDL 827
RR+L +ELDE S E +E L+ L
Sbjct: 1899 NRRKLQ---RELDEATESNEAMGREVNALKSKL 1928
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 150 bits (379), Expect = 7e-36
Identities = 212/1053 (20%), Positives = 442/1053 (41%), Gaps = 124/1053 (11%)
Query: 117 LKFLNNQY-AHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDE 175
+ FL NQ H L+L KE+ +N R+ LH V++ K S+ + ++D
Sbjct: 1760 MDFLGNQEDIHNLQLRVKETSNENLRL-------LH-VIEDRDRKVESLL--NEMKELDS 1809
Query: 176 PVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIE 235
+ EV I +++ + + EL++E L EKL ++ +++E
Sbjct: 1810 KLHLQEVQLMTK-------IEACIEL-EKIVGELKKENSDLSEKLEYFSCDHQELLQRVE 1861
Query: 236 LREREIERLSVALDGGRSPDV---------------LSLE---SRNKTNEKLIAH--LNI 275
E L + D D+ L +E SR ++ + I H L +
Sbjct: 1862 TSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL 1921
Query: 276 QVDF---------LQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLA 326
+ D L++ N++ +K I L E VTSE L + + + ++ T +DQL+
Sbjct: 1922 EADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLS 1981
Query: 327 -------QQLERHKEEVL---ETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQ 376
Q+LE H+ E L + A+ E+ E + ++ S++ +L + LQ +L +
Sbjct: 1982 EKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLE 2041
Query: 377 KEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRR 436
K+ + LS L K +LE + QL +EK+ L K+ ES R + E++ + ++
Sbjct: 2042 KDSQALS---LTKCELENQIAQLNKEKELLVKESESLQA--RLSESDYEKLNVSKALEAA 2096
Query: 437 DRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNS 496
L +EE ++ +E+L+ I+ A EK + + +
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIE---------ADEKKQLHIAEKLKERER 2147
Query: 497 EIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQ 556
E + + + L+R L+ E+ E + + + AE + L E L +
Sbjct: 2148 ENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT 2207
Query: 557 TTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCV 616
+ ++ +EK+ LS+L ++++ ++L LE E+ + K E + +E L
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSL---LEEKEQAEIQIKEESKTAVEMLQNQ 2264
Query: 617 NHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQL 676
+L L IMK T +SL+ ++ + Q + + + + + V +QL
Sbjct: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
Query: 677 QRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTI-GVIDKE 735
+ S +H + +G +E+ + +++I + L+ + E +K I G+
Sbjct: 2325 KES----EHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
Query: 736 KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSL 795
+ + V ++EK NL L +++ +++++I+ S E+ + + ++ V + ++
Sbjct: 2381 RGLELDVVTIRSEK-ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 796 RRQLDAAHKELDE----VGRSREIAFKENRRLQDDLATMARENQEISLELEAA------- 844
L KEL+E + +E + + L + + E ++ L+ A
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 845 -----------------VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLH 887
+++K+E SR+ I + + S ++ E E+Q ++ L
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 888 NRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQIS 947
N + E K + +++S++ L + + ++L +EL + + ++ +++
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD-------KMSFVEKVN 2612
Query: 948 SMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVV 1007
M + L+ E+ + A + +LS + +L ++ +++ S + + + +
Sbjct: 2613 KMTAKETELQREMHEMAQKTAELQEELSGEKN---RLAGELQLLLEEIKSSKDQLKELTL 2669
Query: 1008 ELENVKSESDLLKKQLSNERHTVKN--LESLLATNRDKEFHSHL---TSHEKDTEIQLLK 1062
E +K D + K + V+ E L + ++ H L T+ + + EIQ +
Sbjct: 2670 ENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729
Query: 1063 EKLTLSESKLTSQSRENTMLRAKVAQLQTDYDA 1095
EKLT E L+SQ E +L++ +L A
Sbjct: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Score = 140 bits (352), Expect = 9e-33
Identities = 199/1123 (17%), Positives = 479/1123 (42%), Gaps = 109/1123 (9%)
Query: 49 QSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLK 108
+S L K + S+ FD P+ L+ +L +N EL ++ +L H KE+K +
Sbjct: 256 RSTLQIGKRDANSSFFDNSSSPHLLD--QLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
Query: 109 KCARETADLKFLNNQYAHKLKLLEK-------------ESKAKNERIQQLQEK---NLHA 152
K L+ + K K+L K ++ K ++Q +K +L
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 153 VVQTPGGKKRSI--AFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADL---LQVADNRIQ 207
Q + S+ + + + E + + S + Q A L LQ A N
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 208 ELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNE 267
LQ E+ +L +E+ + ++ +++ E+ + + + R S+E K N
Sbjct: 434 VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRR----SMEEMKKENN 489
Query: 268 KLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTE-IDQLA 326
L +H + + +L K I++ + + E+ + E + ++L E I+Q
Sbjct: 490 LLKSHSEQKAREVCHLEAEL-KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
Query: 327 QQLERHKEEV-LETADKELGEAKKEIKRKLSEMQDLEETMAKLQLE-------LNLCQKE 378
L K ++ + +K+ ++ +K++ ++ L + ++K + E L L +KE
Sbjct: 549 NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
Query: 379 KERLSDELLV----KSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIK 434
E L +E + KS+ E ++ Q+E EK+ L K+ LE +K
Sbjct: 609 YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN----------------HLETCLK 652
Query: 435 RRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDY 494
+ + ++ +E +R+ E+ L +++ +S +K + +K ++
Sbjct: 653 TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE---TQKLAYMELQQKAEF 709
Query: 495 NSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALR--- 551
+ + HQ +E + + + +ED++ ++LL+ E Y + E +LR
Sbjct: 710 SDQKHQ--KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLL 767
Query: 552 --KESTQTTAPHNIVSLMEKEKELAL-SDLRRIMAEKEALREKLEHIEEVSLFGKSELEK 608
K+++ T + SL+ +++ A+ I+ E+ ++ + + E ++
Sbjct: 768 KSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC-------RLEADQ 820
Query: 609 TIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQ-KFSHVAGDSSHQKTEVN 667
+ ++ + ++++S ++ L+S+ + + + E ++++ + + + + + HQ
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE 880
Query: 668 SLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKK 727
+ + ++ +LQ +Q+ ++ LE+ + ++++L +K++ ++ + H+++
Sbjct: 881 TSQRIS-KLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLED 939
Query: 728 TIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVN 787
++ KE L ET+ + ++++++ + + + Q + E +S+NQ K L+
Sbjct: 940 SL----KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQ 995
Query: 788 RDREINSLRRQLDAAHKELDEVGRSREIAF----KENRRLQDDLATMARENQEISLELEA 843
+ + + + + EL + + ++ +E +DL+ + QE + +LE
Sbjct: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLEC 1055
Query: 844 AVQE--------KEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEV 895
+ E K E++ + E + + +A E+ NQ+L ML +
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL-----MLELETVQQAL 1110
Query: 896 KAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSR 955
++ + +++S + E + E L+E ++KE+ + + + + + + +
Sbjct: 1111 RSEMTDNQNNS-KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL 1169
Query: 956 LEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSE 1015
E +R+ E+ + N + ++ +++ K+I N++ ++ E ++ E E
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEV---KEISLDSYNAQLVQLEAMLRNKELKLQE 1226
Query: 1016 SDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQ 1075
S+ K+ L +E T++ L T+ ++ S S KD EI +EK +L++
Sbjct: 1227 SEKEKECLQHELQTIR---GDLETSNLQDMQSQEISGLKDCEID-AEEKYISGPHELSTS 1282
Query: 1076 SRENTMLRAKVAQLQTDYDALKR---QISTERYERERAIQEMR 1115
+N L+ + + L++ + E+YE + + R
Sbjct: 1283 QNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSR 1325
Score = 124 bits (310), Expect = 7e-28
Identities = 236/1142 (20%), Positives = 462/1142 (40%), Gaps = 169/1142 (14%)
Query: 23 QTLTVECLPLVEKLFSDL-----VHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENA- 76
QTL EC+ + +L +L +H KL++VK + E+ +F + + E A
Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF 467
Query: 77 --------RLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKL 128
L R E+ E L+ HS+Q +E+ C E A+LK + Q ++
Sbjct: 468 QASQIKENELRRSMEEMKKENNLLKSHSEQKAREV------CHLE-AELKNIK-QCLNQS 519
Query: 129 KLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVP 188
+ +E KAKN QE L + + ++ S+ + ++ + + + S
Sbjct: 520 QNFAEEMKAKNTS----QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQ---- 571
Query: 189 QPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLS--- 245
DLL+ ++ I+ QL +KL+ E + +EL+++E E L
Sbjct: 572 --------DLLKKREHHIE-------QLNDKLSKTEKESKALLSALELKKKEYEELKEEK 616
Query: 246 VALDGGRSPD---VLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVT 302
+S + + +ES + + I HL + Q + + +R+R L +E ++
Sbjct: 617 TLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLS 676
Query: 303 SEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLE 362
E+ NL N + E+ +L++ E + KE+ + + +++DLE
Sbjct: 677 VEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
Query: 363 ETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTL 422
KLQL LS+E++ K +H + + L K ++ VT
Sbjct: 737 H---KLQL-----------LSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNED--- 779
Query: 423 EVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREK 482
+ + D+ P+ +F I E+ +R C K
Sbjct: 780 ------HQRSLLAFDQQPAMHHSFANIIGEQGSMPS----------ERSECRLEADQSPK 823
Query: 483 SSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNE 542
+S + + +LQ+ E + +I+ N L+ AE+ S + E
Sbjct: 824 NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN--LMKAEQMHQSFV-AE 880
Query: 543 AQEELSALRKEST--QTTAPHNIVSLMEKEKELALSDLRRIMAEKEALRE--KLEHIEEV 598
+ +S L+++++ Q + +L KEKEL L + ++ E+ ++E K H+
Sbjct: 881 TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN-DKVETEQAEIQELKKSNHL--- 936
Query: 599 SLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESL--ENKLKVQAQKFSHVA 656
LE +++ L ++ L EK E+ S + + K IE L EN + +
Sbjct: 937 -------LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE 989
Query: 657 GDSSHQKTE--VNSLRIVNEQLQRSVDDYQHR--LSIKRGE-----LESAQAQIKILEEK 707
+ QK+E N + + + D Y+ + ++R E E + K +EK
Sbjct: 990 KMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK 1049
Query: 708 IDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQE---NLANKEKAV 764
+L + +E + + +++ K+ + E K+A +E NL + + V
Sbjct: 1050 NSKLECLL---NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETV 1106
Query: 765 AQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQ 824
Q + SE + N K +EI +L+ + + KE++++ +EN +L
Sbjct: 1107 QQ--ALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL-------LQENEQLM 1157
Query: 825 DDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQ 884
+ T S + +V+E+E +++ + E + + N L+
Sbjct: 1158 KVMKTKHECQNLESEPIRNSVKERESERNQCN--FKPQMDLEVKEISLDSYNAQLVQLEA 1215
Query: 885 MLHNRAEDWEVKAHQAEGESSSVRLELLSI--DTERRHLRERVELLEKEIQEHINAHHAY 942
ML N+ E+K ++E E ++ EL +I D E +L+ ++ +EI +
Sbjct: 1216 MLRNK----ELKLQESEKEKECLQHELQTIRGDLETSNLQ---DMQSQEISGLKDCEIDA 1268
Query: 943 ESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNL-- 1000
E + S +S + + H + T +N L+ L ++C L + K + +LN
Sbjct: 1269 EEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSEC 1328
Query: 1001 ---------EFERVVVELENVKSESDLLKKQL------------SNERHTVKNLESLLAT 1039
E +++ E++ + +S LL +L NE+H V LA
Sbjct: 1329 ITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS-----LAP 1383
Query: 1040 NRDKEFHSHLTSHEKDTEIQL--LKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALK 1097
+ + HLT +K+ ++ L+EK +S+ ++ + +K+++LQT D+LK
Sbjct: 1384 LDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLK 1443
Query: 1098 RQ 1099
+
Sbjct: 1444 AE 1445
Score = 123 bits (308), Expect = 1e-27
Identities = 200/967 (20%), Positives = 403/967 (41%), Gaps = 161/967 (16%)
Query: 2 TTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKES 61
TTA+++ ++++ +L Q+ ECL ++ +++ TE L+ + K+
Sbjct: 1974 TTALDQLSEKMKEKTQELESHQS---ECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
Query: 62 ANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLN 121
+ L+ + ++ LS EL ++ +L + + VKE ++ + + +D + LN
Sbjct: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE--SDYEKLN 2088
Query: 122 NQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSE 181
A + L+EK A R+ QE+ +H + +R I R R++ DE
Sbjct: 2089 VSKALEAALVEKGEFAL--RLSSTQEE-VHQL-------RRGIEKLRVRIEADEK----- 2133
Query: 182 VSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREI 241
+IA+ L+ + L+ +V L+ +L M E E + E+
Sbjct: 2134 ---------KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 242 ERLSVALDG-GRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRI---RELMET 297
E L ++ RS V L+ +EK +L Q+ Q +L+K + + L+E
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEK--ENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 298 KETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETA-DKELGEAKKE-IKRKL 355
KE ++ S T ++ L QL+ E V D+E+ +A ++ + +
Sbjct: 2243 KEQAEIQIKEESK---------TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI 2293
Query: 356 SEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAV 415
E L ++ KL+ L +K+ +L V L+ H + K R+
Sbjct: 2294 EEEHQLRNSIEKLRARLEADEKK------QLCVLQQLKESEHHADLLKGRVEN------- 2340
Query: 416 TERQLTLEVERMRLEHGIKRRDRSPSRLDTF----------LKGIEEERDYYKKELERLQ 465
ER+L E+ R EH + S ++T L+G+E + + E E L
Sbjct: 2341 LEREL--EIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT 2398
Query: 466 HIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERD-ELQRMLERFEKYMEDIQS 524
+ +Q+ R E NS I +E++ E +M E+ ME +Q+
Sbjct: 2399 NELQKEQ-------------ERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQT 2445
Query: 525 NVKLLTAERDKLSVLYNEAQ----------EELSALRKESTQTT-----APHNIVSLME- 568
+K L ++++ L+N+ + ++ L E Q A +N + L
Sbjct: 2446 QLKELN---ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSS 2502
Query: 569 ---------------KEKELALSDLRRIMAEKEALREKLEHIE-EVSLFGKSELEKTIEH 612
++K+ +S L+ + ++E L KL +E E L+ + LE + +
Sbjct: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE--LRN 2560
Query: 613 LTCVNHQ----LESEKYELKSKVLIMKETIESLENKLKVQ-------AQKFSHVAGDSSH 661
LT Q L+S+ L+ + +++ + ++LEN+L++ +K + + +
Sbjct: 2561 LTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETE 2620
Query: 662 QKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTS---- 717
+ E++ + +LQ + ++RL+ GEL+ +IK ++++ EL L+ +
Sbjct: 2621 LQREMHEMAQKTAELQEELSGEKNRLA---GELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 718 ---------------QDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEK 762
++E A + K + L +T + +I +E L +KE+
Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737
Query: 763 AVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRR 822
++ K+ I +SS +L +L + + L++ K ++++ + E A + +
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797
Query: 823 LQDDLATMARENQEISLELEA--AVQEKEE----MKSRVHKYITEVSRWESLMAAKEKEN 876
L + E + + EL A QEK++ M ++V + TE+ + + K KE
Sbjct: 2798 LIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEA 2857
Query: 877 QDLLDRF 883
+ LD++
Sbjct: 2858 DEYLDKY 2864
Score = 121 bits (304), Expect = 3e-27
Identities = 178/980 (18%), Positives = 400/980 (40%), Gaps = 175/980 (17%)
Query: 287 LEKRIRELMETKETVTSEVVNLSNKNEKL---CQELTEIDQ-LAQQLERHKEEV------ 336
LE +++ + E +E NL +N++L C+ L + Q ++ +L+ + +V
Sbjct: 44 LEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQ 103
Query: 337 LETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVK------- 389
L + K++ + ++E+KR SE++ ++ + LN C ++ + L
Sbjct: 104 LNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSK 163
Query: 390 -SDLETVVHQLEQEKQRLSKKVESFAVTERQLTL--------EVERMRLEHGI--KRRDR 438
DL+ ++ +E++RL +V++ + TL ++ R + + ++++
Sbjct: 164 YEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEK 223
Query: 439 SPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEI 498
+PS L + + RD+ Q + RS SS F D +S
Sbjct: 224 TPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFF------DNSSSP 277
Query: 499 HQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTT 558
H + + + + Q + + + +Q + K + + +K + E Q +L +
Sbjct: 278 HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK----FQELQLQLEKAK------- 326
Query: 559 APHNIVSLMEKEKEL--ALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCV 616
V L+EKEK L +L R A+ + K +E+ +L+K E L+C
Sbjct: 327 -----VELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ-------KLKKLTEDLSCQ 374
Query: 617 NHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQK------------- 663
ES + L+ K+ KE + + +L Q + F + + K
Sbjct: 375 RQNAESARCSLEQKI---KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNM 431
Query: 664 -----TEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELN-----L 713
E++ L V +QL+ ++++++ +L +++Q + L ++E+ L
Sbjct: 432 HNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLL 491
Query: 714 KMTSQDEEAHV------MKKTIGVIDKEKDFLQETVDEKTEK---IANLQENLANKEKAV 764
K S+ + V +K +++ ++F +E + T + + +LQE + +E ++
Sbjct: 492 KSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL 551
Query: 765 A--QMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRR 822
++K+ +++ E + ++ L R+ I L +L KE + + E+ KE
Sbjct: 552 TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 823 LQDD---LATMARENQEISLELEAAVQEKEEMKSRVHKYIT-------EVSRWESLMAAK 872
L+++ + EN+++ ++E+ EKE ++S+++ T + + +
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMES---EKENLQSKINHLETCLKTQQIKSHEYNERVRTL 668
Query: 873 EKENQDLLDRFQMLHNRAEDWEVKA--------------------HQAEGESSSVRLELL 912
E + ++L + LHN + V+ HQ E E+ ++ L
Sbjct: 669 EMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQL 728
Query: 913 SIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVL- 971
+ E L +++LL EI + + ++ S+ + + L ED + ++L
Sbjct: 729 TGQVE--DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLA 786
Query: 972 ------------------NDLSSLRELC-----------IKLDSGKDIMTQQLNSK---N 999
+ S R C L + D + L S+ N
Sbjct: 787 FDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMN 846
Query: 1000 LEFERVVVELENVKS--ESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTS------ 1051
+ ++ EL +K E +L+K + ++ + + + D H ++ +
Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 1052 HEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDAL---KRQISTERYERE 1108
K+ E+QLL +K+ ++++ + N +L + +LQ + L K+++S+ +
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
Query: 1109 RAIQEMRRHGLATPPLSSTL 1128
R I+E+ + ++++L
Sbjct: 967 REIEELTQENGTLKEINASL 986
Score = 101 bits (252), Expect = 4e-21
Identities = 198/966 (20%), Positives = 385/966 (39%), Gaps = 149/966 (15%)
Query: 203 DNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+ IQEL+Q + +++L + + Y + E ++++ +++ ++ L +
Sbjct: 1578 NKEIQELEQLLSSERQELDCLR---KQYLSENEQWQQKLTSVTLEMES-------KLAAE 1627
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVT--SEVVNLSNKNEKLCQELT 320
K E+L L ++V LQ DL R ++T++ + +E ++S ++ E T
Sbjct: 1628 KKQTEQL--SLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERT 1685
Query: 321 ---EIDQLA-----QQLERHKEEVLET-ADKELGEAKKEIKRKLS-EMQDLEETMAKLQL 370
++ Q+ Q L E++ ET A K GE E + E ++T +
Sbjct: 1686 PKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSE- 1744
Query: 371 ELNLCQKEKERLSDELLVKSDL---ETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERM 427
C E LV D + +H L+ + S E +
Sbjct: 1745 ----CISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN----------------ENL 1784
Query: 428 RLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFR 487
RL H I+ RDR L +K ++ K L+ +Q + + +C EK
Sbjct: 1785 RLLHVIEDRDRKVESLLNEMKELDS-----KLHLQEVQLMTKIEACIEL----EKIVGEL 1835
Query: 488 TPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAE---------RDKLSV 538
E D + ++ + + EL + +E E D++ + + E D
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE 1895
Query: 539 LYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEV 598
+ + + ELS +R E +E E +DL + EK L + E+ ++V
Sbjct: 1896 RFLDVENELSRIRSEKAS----------IEHEALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Query: 599 SLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGD 658
+ LE+ + +T +QL E + K ++ L K+K + Q+
Sbjct: 1946 IVC----LEEELSVVTSERNQLRGELDTMSKKTT----ALDQLSEKMKEKTQELE----- 1992
Query: 659 SSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQ 718
SHQ ++ +++ +++ + Q LS EL + L+EK+ L +
Sbjct: 1993 -SHQSECLHCIQVAEAEVKEKTELLQ-TLSSDVSELLKDKTH---LQEKLQSLEKDSQAL 2047
Query: 719 DEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSV 778
++ I ++KEK+ L + + +++ N KA+ + E +
Sbjct: 2048 SLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107
Query: 779 NQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLAT------MAR 832
+ +E + R I LR +++A K+ + + +EN L+D + M+
Sbjct: 2108 SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSE 2167
Query: 833 ENQE-ISLELEAAVQEKEEMKSRVHKYITEVSRWE----SLMAAKE------KENQDLLD 881
ENQE + L+ E + E E +K+++ + + +E +L + KE +E Q L
Sbjct: 2168 ENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLS 2227
Query: 882 RFQMLHNRAEDWEVKAHQAE---GESSSVRLELLSIDTERRHLRERVELL------EKEI 932
L + + + QAE E S +E+L + + L E V L K
Sbjct: 2228 ELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML--QNQLKELNEAVAALCGDQEIMKAT 2285
Query: 933 QEHINAHHAYESQI-SSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIM 991
++ ++ E Q+ +S+ K +RLE + E ++ VL L L + +
Sbjct: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEAD----EKKQLCVLQQLKESEHHADLLKGRVENL 2341
Query: 992 TQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTS 1051
++L E +E EN K E + LK ++ +++ LE + T R ++ +LT+
Sbjct: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEK--ENLTN 2399
Query: 1052 -----HEKDTEIQLL------------KEKLTLSESKLTSQSRENTMLR---AKVAQLQT 1091
E+ +E++++ +EK+ + E T+ T L+ +VA L
Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
Query: 1092 DYDALK 1097
D +A K
Sbjct: 2460 DQEACK 2465
Score = 94.0 bits (232), Expect = 7e-19
Identities = 257/1299 (19%), Positives = 499/1299 (38%), Gaps = 252/1299 (19%)
Query: 33 VEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKL 92
++K +DL+ E L + +K + E N LE + N+ RE+
Sbjct: 1142 MQKEVNDLLQENEQL----MKVMKTKHECQN----LESEPIRNSVKERESER---NQCNF 1190
Query: 93 REHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQ----QLQEK 148
+ D VKE+ SL + L+ + KL+ EKE + +Q L+
Sbjct: 1191 KPQMDLEVKEI--SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETS 1248
Query: 149 NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQE 208
NL + + + I P E+S+ Q D+ ++ LQ N++ E
Sbjct: 1249 NLQDMQSQEISGLKDCEIDAEEKYISGP---HELST---SQNDNAHLQCSLQTTMNKLNE 1302
Query: 209 LQQEVHQLQ-EKLAMME----------SGVRDYSKQIELREREIERL---SVALDGGRSP 254
L++ LQ EK ++ + R ++++ E++ L S L G
Sbjct: 1303 LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVE 1362
Query: 255 DVLSLESRNKTNEKLIAHL-----NIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLS 309
D+ E + NE+ L + + L ++K+++ EL E ++ SE L
Sbjct: 1363 DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILH 1422
Query: 310 NKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIK----------------- 352
+++ ++ +++E+ L+ + G+ KE++
Sbjct: 1423 DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVP 1482
Query: 353 --RKLSEMQD-------LEET-----MAKLQ--LELNLCQKEK---ERLSDELLVKSD-- 391
LS + D LE+T ++ L+ + N C ++ L +E L + +
Sbjct: 1483 DSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETP 1542
Query: 392 ---------LETVVHQLEQEKQRLSKKVESFA------VTERQLTLEVERMRLE----HG 432
LE++ Q ++L +K+ES + E + L ER L+
Sbjct: 1543 SAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQY 1602
Query: 433 IKRRDRSPSRLDTFLKGIEEERDYYKKELERL--------------------------QH 466
+ ++ +L + +E + KK+ E+L +
Sbjct: 1603 LSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTED 1662
Query: 467 IIQRRSCSTSYSAREKS-SIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSN 525
IQ R+ S S S + RTP+ ++HQI ++D Q + EK E
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPK-----HDVHQIC-DKDAQQDLNLDIEKITETGAVK 1716
Query: 526 VKLLTAERDKLSVLYNEAQEE--------LSALRKESTQTTAP-------HNIVSLMEKE 570
+ Y E+ +S L P +I +L +
Sbjct: 1717 PTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRV 1776
Query: 571 KELALSDLR-------------RIMAEKEALREKLEHIEEVSLFGK----SELEKTIEHL 613
KE + +LR ++ E + L KL H++EV L K ELEK + L
Sbjct: 1777 KETSNENLRLLHVIEDRDRKVESLLNEMKELDSKL-HLQEVQLMTKIEACIELEKIVGEL 1835
Query: 614 TCVNHQLESEKYELKS----KVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSL 669
N L SEK E S ++L ET E L + L++ A D S ++ +++
Sbjct: 1836 KKENSDL-SEKLEYFSCDHQELLQRVETSEGLNSDLEMHA--------DKSSREDIGDNV 1886
Query: 670 RIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKI-----DELNLKMTSQDEEAHV 724
VN+ + D ++ LS R E S + + LE + ++L L+ +++++ +
Sbjct: 1887 AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVI 1946
Query: 725 --MKKTIGVIDKEKDFLQ---ETVDEKTEKIANLQENLANK------------------E 761
+++ + V+ E++ L+ +T+ +KT + L E + K E
Sbjct: 1947 VCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAE 2006
Query: 762 KAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDA-------AHKELDEVGRSRE 814
V + ++ S V++L + + ++ SL + A ++ ++ + +E
Sbjct: 2007 AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 815 IAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSR-------VHKYITEVSRWES 867
+ KE+ LQ L+ E +S LEAA+ EK E R VH+ + +
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRV 2126
Query: 868 LMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGE--SSSVRLELLSIDTERRHLRERV 925
+ A EK+ + ++ + + + K E E S EL+ +D E + + V
Sbjct: 2127 RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE--NSKAEV 2184
Query: 926 ELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLR------- 978
E L+ +I+E + +E + ++ L ++++ ++ + + + LSS +
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 979 --ELCIKLDS--GKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNE---RHTVK 1031
E+ IK +S +++ QL N + + E +K+ L + E R++++
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 1032 NLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKL----TSQSR---------- 1077
L + L + K+ E + LLK ++ E +L T+Q
Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG 2364
Query: 1078 ENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRR 1116
E L+AK+ + L+ + T R E+E E+++
Sbjct: 2365 EVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK 2403
Score = 84.0 bits (206), Expect = 8e-16
Identities = 139/671 (20%), Positives = 276/671 (41%), Gaps = 92/671 (13%)
Query: 506 DELQRMLERFEKYMEDIQSNVKLLTAERDKLSVL---YNEAQEELS-ALRKESTQTTAPH 561
D L+ L++ ++ +E+ ++ L E +L + + ++++S L+ + +Q
Sbjct: 42 DSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQE 101
Query: 562 NIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLE 621
++ +K+ E +L+R +E E ++ + + VSL + +K +
Sbjct: 102 GQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD-VSLNPCNTPQKIFTTPLTPSQYYS 160
Query: 622 SEKYE-LKSKVLIMKETIESLENKLK-VQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRS 679
KYE LK K E + LE ++K +QA+K S ++ +N I Q S
Sbjct: 161 GSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQAT-----MNHRDIARHQASSS 215
Query: 680 VDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKT--IGVIDKEKD 737
V +Q + S + I+ + + S ++E + T IG D
Sbjct: 216 VFSWQQEKTPSHLSSNSQRTPIR------RDFSASYFSGEQEVTPSRSTLQIGKRDANSS 269
Query: 738 F------------LQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETL 785
F L+ E KI L+ L EK + E + + + K L
Sbjct: 270 FFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL 329
Query: 786 VNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAV 845
+ +++ +N R +L + D+ ++ ++L +DL+ + + LE +
Sbjct: 330 IEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKI 389
Query: 846 QEKE----------------------EMKSRVHKYITEVSRWESLMAAKEKENQDLLDRF 883
+EKE +MK+R+ + + + +++ A E L
Sbjct: 390 KEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA---ELDKLTSVK 446
Query: 884 QMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYE 943
Q L N E+++ K +AE + +++ + +++ LL+ ++ E
Sbjct: 447 QQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506
Query: 944 SQISSMAKAMSRLE---EELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNL 1000
+++ ++ + +++ + EE++ + + T+L DL ++ + QQ NS L
Sbjct: 507 AELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL-------------QEKINQQENSLTL 553
Query: 1001 E-FERVVVELENVKS-ESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE-KDTE 1057
E + V +LE + DLLKK+ H ++ L L + +KE + L++ E K E
Sbjct: 554 EKLKLAVADLEKQRDCSQDLLKKR----EHHIEQLNDKL-SKTEKESKALLSALELKKKE 608
Query: 1058 IQLLKEKLTL-------SESKLTSQSRENTMLRAKVAQLQTDYDALK-RQISTERYERER 1109
+ LKE+ TL +E LT E L++K+ L+T LK +QI + Y
Sbjct: 609 YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET---CLKTQQIKSHEYNERV 665
Query: 1110 AIQEMRRHGLA 1120
EM R L+
Sbjct: 666 RTLEMDRENLS 676
Score = 66.2 bits (160), Expect = 2e-10
Identities = 123/622 (19%), Positives = 258/622 (41%), Gaps = 81/622 (13%)
Query: 565 SLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEK 624
+L E ++ L L++I E E +KL+ ++ F LE ++ ++E+EK
Sbjct: 4 ALEEWKEGLPTRALQKIQ-ELEGQLDKLKKEKQQRQFQLDSLEAALQKQ---KQKVENEK 59
Query: 625 YE---LKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVD 681
E LK + + E ESLE + + + + Q+ ++NS + E+L++ +
Sbjct: 60 TEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK 119
Query: 682 DYQHRLSIKRGELESAQAQI-------KILE-----------EKIDELNLKMTSQDEEAH 723
+ L + +SA + KI K ++L K + EE
Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 724 VMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKE 783
++ + + +K +T+ + T ++ + A+ Q + S S+ +
Sbjct: 180 RLEAEVKALQAKK--ASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN---SQR 234
Query: 784 TLVNRDREIN--SLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEIS--- 838
T + RD + S +++ + L R +F +N L + +NQE+
Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKI 294
Query: 839 LELEAAVQ-EKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKA 897
ELE +Q ++EMK +V+K+ + L EK +L+++ ++L N+ D E+
Sbjct: 295 NELELRLQGHEKEMKGQVNKF-------QELQLQLEKAKVELIEKEKVL-NKCRD-ELVR 345
Query: 898 HQAEGESSSVRLELL----------------SIDTERRHLRERVELLEKEIQEHIN-AHH 940
A+ + +S + L + ++ R L ++++ EKE QE ++
Sbjct: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 941 AYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNL 1000
++++ + +RL +EL+ ++ + +L L + +L++ + Q+L
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
Query: 1001 EFERVVVE-------LENVKSESDLLKKQLSNERHTVKNLESLL-----ATNRDKEFHSH 1048
F+ ++ +E +K E++LLK + V +LE+ L N+ + F
Sbjct: 466 AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525
Query: 1049 LTSHEKDTEIQL--LKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYE 1106
+ + E L L+EK+ E+ LT + L+ VA L+ D + + +
Sbjct: 526 MKAKNTSQETMLRDLQEKINQQENSLTLEK-----LKLAVADLEKQRDCSQDLLKKREHH 580
Query: 1107 RERAIQEMRRHGLATPPLSSTL 1128
E+ ++ + + L S L
Sbjct: 581 IEQLNDKLSKTEKESKALLSAL 602
Score = 39.7 bits (91), Expect = 0.016
Identities = 64/362 (17%), Positives = 144/362 (39%), Gaps = 60/362 (16%)
Query: 10 INIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLE 69
+ + +++ L + + L +++ + +L + E + K+S V+ + + L+
Sbjct: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQ 2622
Query: 70 PYKLENAR--------LSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLN 121
E A+ LS E N L EL L E +K K LK+ E ++LK +
Sbjct: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEE----IKSSKDQLKELTLENSELK-KS 2677
Query: 122 NQYAHKLKLLEKESKAKNE------RIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDE 175
HK ++ EKE K + E R+ + ++K+ ++ T + I R+++ E
Sbjct: 2678 LDCMHKDQV-EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKE 2736
Query: 176 PVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQE-------VHQL-------QEKLA 221
S+ + + + + L+ ++EL++ V+QL Q K+
Sbjct: 2737 ECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMK 2796
Query: 222 MMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQ 281
++ + ++ E+ ++E+ +L A + ++ V+ +
Sbjct: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTK--------------------- 2835
Query: 282 QANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETAD 341
+++ E+ E KET+ + +K C L ++L + E + +V
Sbjct: 2836 -----VDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCS 2890
Query: 342 KE 343
++
Sbjct: 2891 QQ 2892
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 146 bits (368), Expect = 1e-34
Identities = 249/1165 (21%), Positives = 497/1165 (42%), Gaps = 171/1165 (14%)
Query: 68 LEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHK 127
LE LE L +E E+ L + ++Q + EL +S E ADL+ + +
Sbjct: 549 LESSHLEGELLRQEQTEVTAALAR----AEQSIAELSSSENTLKTEVADLRAAAVKLSAL 604
Query: 128 LKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPV 187
+ L + N+++ QL+E+N Q+ + + R +Q+D +
Sbjct: 605 NEALALDKVGLNQQLLQLEEEN-----QSVCSRMEAAEQARNALQVDLAEAEKRREAL-- 657
Query: 188 PQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVA 247
+ ++ LQ A+ ELQ ++ +QE+ ++ + + Q E ++E+L
Sbjct: 658 -WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ- 715
Query: 248 LDGGRSPDVLSLESRNKTNEKLI---AHLNIQVDFLQQANKDLEKRIRELMETKETVTSE 304
+ R +VL+ + K E L+ A L +++ +++ +DL ++++ L KE + S
Sbjct: 716 -EAKRQEEVLARAVQEK--EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
Query: 305 VVNLSNKN----------EKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRK 354
+ +N E Q +T+ ++ Q R + L+T + + + R+
Sbjct: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQ 832
Query: 355 LSEMQD-----LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKK 409
L++ + LE+ A + E+N +++ E+ + + +L + LE+EK L +
Sbjct: 833 LAQAEQEGKTALEQQKAAHEKEVNQLREKWEK--ERSWHQQELAKALESLEREKMELEMR 890
Query: 410 V-------ESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELE 462
+ E+ + + E + ++ S L+T L+ +E D ++LE
Sbjct: 891 LKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADA-SQQLE 949
Query: 463 RLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRE-RDELQRMLER------- 514
RL+ ++ + +E + I +T + + E+ + R+ RD+L + E
Sbjct: 950 RLRQDMKVQKLKE----QETTGILQT-QLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 515 ---FEKYMEDIQSNVKLLTAERDKLSVLYNEAQEEL------SALRKESTQTTAPHNIVS 565
+K +ED++S L A+ D ++ E QE+L + ++KE + A + S
Sbjct: 1005 KMDLQKQVEDLKSQ---LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL-S 1060
Query: 566 LMEKEKELA------------LSDLRRIM-----------AEKEALREKLEHIEEVSLFG 602
LMEKE+ L LS LR+ M A+ E LR++++ E L
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQ 1120
Query: 603 KSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQ 662
+++L + +E QL + + ++K ++ + S E++L+ A + G+ +
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQAQA 1178
Query: 663 KTEVNSLRIVNEQLQRSVDDYQHRLS----------------------IKRGELESAQAQ 700
+ ++ SL +Q SV + + LS KRG L +A +
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSA 1238
Query: 701 IKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTE---KIANLQENL 757
+ + + +L+ + + V++ + K ++ L +T EK++ ++ +LQ L
Sbjct: 1239 -EAVASALHKLHQDLWKTQQTRDVLRDQV---QKLEERLTDTEAEKSQVHTELQDLQRQL 1294
Query: 758 ANKEKAVAQMKIMISECESSVNQLKETLVN-----RDREINSLRRQ-----LDAAHKELD 807
+ ++ ++ + + ES + +L ET+ + R E+ + Q L AA + L
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT 1354
Query: 808 EVGRSREIAFKENRR-------LQDDLAT----MARENQEISLELEAA--VQEKEEMKSR 854
+ A E R L++DL T + +N+E+ E E A +QE+ E+K
Sbjct: 1355 AQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVA 1414
Query: 855 VHKYITE-VSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLS 913
K + E ++ +A +E+E + L + Q L + + E LELLS
Sbjct: 1415 QGKALQENLALLTQTLAEREEEVETLRGQIQEL------------EKQREMQKAALELLS 1462
Query: 914 IDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRL---EEELRHQEDEKATV 970
+D ++R+ + V+L +++IQE E ++ + +L E++R E ++ T
Sbjct: 1463 LDLKKRN--QEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520
Query: 971 LNDLS-SLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHT 1029
N L L EL KD M + + + ++ +V LE + E + ++ ++
Sbjct: 1521 RNVLEHQLLEL-----EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKL 1575
Query: 1030 VKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQL 1089
+K LE T R H L E+ E+Q ++ ES T +RE +V
Sbjct: 1576 IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ 1635
Query: 1090 QTDYDALKRQISTERYERERAIQEM 1114
+ + L+RQ + ER QE+
Sbjct: 1636 REQIEELQRQKEHLTQDLERRDQEL 1660
Score = 129 bits (325), Expect = 1e-29
Identities = 224/1145 (19%), Positives = 466/1145 (40%), Gaps = 91/1145 (7%)
Query: 7 RKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDF 66
++Y I+K L++ + +LT+ + ++L ++ +S+RQ +LSA++ + + A +
Sbjct: 1041 QEYNRIQKELER--EKASLTLSLMEKEQRLL--VLQEADSIRQQELSALRQDMQEAQGEQ 1096
Query: 67 VLEPYKLENARLSRENNE---LYLELMKLREHSDQHVKE--LKTSLKKCARETADLKFLN 121
++E R + E L E L E H+ E L+ SL + A L+
Sbjct: 1097 KELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRL 1156
Query: 122 NQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSE 181
+L+ L E + N+ Q Q +L++ +Q G S+ R + PS
Sbjct: 1157 RSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG---SVCESRPELSGGGDSAPSV 1213
Query: 182 VSSYPVPQ------PDDPYIADL-LQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQI 234
P P + L + + + +L Q++ + Q+ ++ V+ +++
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273
Query: 235 ELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIREL 294
E E ++ L + + E ++K K + L ++ L + L+ R+R
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNS-LESELMELHETMASLQSRLRRA 1332
Query: 295 METKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRK 354
+ E L E L ++ + Q A R + +++L A+ +K K
Sbjct: 1333 ELQRMEAQGERELLQAAKENLTAQVEHL-QAAVVEARAQASAAGILEEDLRTARSALKLK 1391
Query: 355 LSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKS----DLETVVHQLEQEKQRLSKKV 410
E++ E LQ + L + + L + L + + + E V L + Q L K+
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451
Query: 411 ESFAVTERQLTLEVERMRLE-----HGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQ 465
E L+L++++ E I+ ++ S L+ ++E + E+++
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511
Query: 466 HI-----IQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYME 520
+ QR EK ++G Q+ + L LE ME
Sbjct: 1512 ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT-LECLALELEENHHKME 1570
Query: 521 DIQSNVKLLTAERDK----LSVLYNEAQEELSALRKESTQT--TAPHNIV---SLMEKEK 571
Q +K L +R+ L+ L + +E L+ +S+Q H+ V L E+++
Sbjct: 1571 CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQ 1630
Query: 572 ELALS--DLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKS 629
E+ + + +KE L + LE ++ + K ++ + T LE + ++K
Sbjct: 1631 EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIK- 1689
Query: 630 KVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSI 689
L ++E L + ++ ++ G S Q+ + ++++ ++ V+ Q +
Sbjct: 1690 --LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE 1747
Query: 690 KRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEK 749
+ + + Q++ L K+ E +L ++ +++E V+++ LQE ++ K
Sbjct: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ----------LQEAREQGELK 1797
Query: 750 IANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEV 809
+LQ L ++A+AQ + + Q + + ++L+ L+ AH L E
Sbjct: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER 1857
Query: 810 GRSREIAFKENRRLQDDLATMARENQ---EISLELEAAVQEKEEMKSRVHKYITEVSRWE 866
+ ++ RRL+++LA R Q E+ +L A +E+E+ + + E ++
Sbjct: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ-- 1915
Query: 867 SLMAAKEKENQDLLDRFQMLHN--RAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRER 924
E E + L D + + D E++A +AE +SS RH E
Sbjct: 1916 ----EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS-------------RHQEEA 1958
Query: 925 VELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKL 984
+ +QE + HA + + + E R E AT+ L + + +L
Sbjct: 1959 ARARAEALQEALGKAHA---ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015
Query: 985 DSGKDIMTQQLNSKNLEFERVVVELENVKSESD-LLKKQLSNERHTVKNLESLLATNRDK 1043
+ I ++ ++L ++ V +L+ ++ D L+ Q E+ K+L + N +
Sbjct: 2016 EEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075
Query: 1044 EFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTE 1103
E +L ++ EI+ L + ++ E +LT +E +L + Q + + +AL T
Sbjct: 2076 E-KQNLGQEREEEEIRGLHQ--SVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS 2132
Query: 1104 RYERE 1108
E +
Sbjct: 2133 PMEEQ 2137
Score = 124 bits (311), Expect = 5e-28
Identities = 225/1112 (20%), Positives = 471/1112 (42%), Gaps = 129/1112 (11%)
Query: 49 QSKLSAVKAEKESANFDFV-----LEPYKLENARLSRENNELYLELMKLREHSDQHVKEL 103
+ +L+ +AEK + + L + E ++ + N L ELM+L E + L
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET----MASL 1325
Query: 104 KTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRS 163
++ L++ A+L+ + Q +L KE+ Q A G +
Sbjct: 1326 QSRLRR-----AELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 164 IAFRRQRMQI-DEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAM 222
+ R +++ +E V + + + + +A + +N + L Q + + +E++
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN-LALLTQTLAEREEEVET 1439
Query: 223 MESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEK---LIAHLNIQVDF 279
+ +++ KQ E+++ +E LS+ L R+ +V + + + EK ++ HL + V
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKK-RNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498
Query: 280 LQQANKDLEKRIRELMETKET----VTSEVVNLSNKNEKLCQELTEIDQLAQQL------ 329
+Q ++IREL + +ET + +++ L K++ + + ++ L +QL
Sbjct: 1499 REQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558
Query: 330 ------ERHKEEVLETADKELGEAKKEIKR-KLSEMQ-DLEETMAKLQ--------LELN 373
HK E + KEL E ++E +R L+ + DLEE +LQ LE +
Sbjct: 1559 ALELEENHHKMECQQKLIKEL-EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
Query: 374 LCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGI 433
+E + VKS E + +L+++K+ L++ +E +++L L+ ER+++
Sbjct: 1618 STVLARELQERDQEVKSQREQI-EELQRQKEHLTQDLER---RDQELMLQKERIQVLED- 1672
Query: 434 KRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRR-------SCSTSYSAREKSSIF 486
+R R L+ L+ I+ +EL + ++Q R S + S I
Sbjct: 1673 -QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL 1731
Query: 487 RTPEKGD--YNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQ 544
R EK IH++ +D+L++ L+ + + + LL ++R++ V+ Q
Sbjct: 1732 RDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGE----TSLLLSQREQEIVVL---Q 1784
Query: 545 EELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKS 604
++L R++ L E+ + L + +R +A+++ ++LE +++ +
Sbjct: 1785 QQLQEAREQG----------ELKEQSLQSQLDEAQRALAQRD---QELEALQQEQQQAQG 1831
Query: 605 ELEKTIEHLTCVNHQLESEKYELKSK---VLIMKETIESLENKLKVQA---QKFSHVAGD 658
+ E+ E + LE LK + + KE LE +L V+ Q V GD
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGD 1891
Query: 659 -SSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTS 717
+ + + +L + +Q +++ + AQA +K +++++ L + S
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 718 QDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESS 777
+ + + + + K + + E + E + A ++ + C++
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
Query: 778 VNQLKETLVNRDREINS--LRRQLDAAHKELDEVGRSREIAFKENRR--LQDDLATMARE 833
QL+E L ++ EI LR Q D + R E+ ++ R L+ LA +E
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQE 2071
Query: 834 NQEISLELEAAVQEKEEMKSR-VHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAED 892
N + E + QE+EE + R +H+ + E+ + +A KE+E +L + Q + A
Sbjct: 2072 N--MIQEKQNLGQEREEEEIRGLHQSVREL---QLTLAQKEQEILELRETQQRNNLEALP 2126
Query: 893 WEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKA 952
K E +S L +D+ L+ +E L+ +++ + + +A +
Sbjct: 2127 HSHKTSPMEEQS-------LKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
Query: 953 MSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSG---KDIMTQQLNSKNLEFERVVVEL 1009
+++ KA+V SSL+E+ + L + +D Q+L + LE R +E
Sbjct: 2180 LAQT----------KASV----SSLQEVAMFLQASVLERDSEQQRLQDE-LELTRRALEK 2224
Query: 1010 ENVKSESDLLKKQLSNERHTVKNLESLLATNRDK--EFHSHLTSHEKDTEIQLLKEKLTL 1067
E + S +L + L + + + + ++ +Q +L +
Sbjct: 2225 ERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEI 2284
Query: 1068 SESKLTSQSRENTMLRAKVAQLQTDYDALKRQ 1099
S+L R N LR+ + Q++ + LKR+
Sbjct: 2285 DRSRL---QRHNVQLRSTLEQVERERRKLKRE 2313
Score = 124 bits (310), Expect = 7e-28
Identities = 196/1003 (19%), Positives = 407/1003 (40%), Gaps = 164/1003 (16%)
Query: 205 RIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNK 264
+ QEL++E H+ ++L ++S + ++ EL++R E LS L + +N+
Sbjct: 252 KTQELEKEAHERSQELIQLKS--QGDLEKAELQDRVTE-LSALLTQS--------QKQNE 300
Query: 265 TNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI-- 322
EK+I L V+ L E ELME + +++ +++ +++T++
Sbjct: 301 DYEKMIKALRETVEIL-------ETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353
Query: 323 ---DQLAQQLERHKEEVLET----------ADKELGEAKKEIKRKLSEMQDLEETMAKLQ 369
D +AQ L++ ADK L + + R+ +QDL + +A Q
Sbjct: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413
Query: 370 LELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRL 429
+NL Q++ ++ +E L Q Q+L+ + ++ A L EV+ +
Sbjct: 414 EAVNLLQQQHDQWEEE----------GKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK 463
Query: 430 EHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTP 489
E + ++ R R L+ +E+E L R+ +Q + S
Sbjct: 464 ERELLQKAREELRQQ--LEVLEQEA----WRLRRVNVELQLQGDSAQ------------G 505
Query: 490 EKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSA 549
+K + E+H RER+ LQ ML E + S + L R+ L + E +
Sbjct: 506 QKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITL---REALESSHLEGE----L 558
Query: 550 LRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT 609
LR+E T+ TA E + + L+ +A+ A KL + E K L +
Sbjct: 559 LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQ 618
Query: 610 IEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSL 669
+ L N + S + ++ + E + + +K +H+ + L
Sbjct: 619 LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 670 RIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKIL--EEKIDELNLKMTSQDEEAHVMKK 727
+ +Q ++ Q +LS R + E+A Q++ L E K E L Q++EA V +K
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 728 T-----IGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECE---SSVN 779
+ +++++ L E + + L+ +L ++ + +++ + E +V
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 780 QLKETL--------VNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMA 831
Q KE + + D E + ++ DAA ++L + + + A ++ + +
Sbjct: 799 QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 832 REN---------QEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKEN------ 876
RE QE++ LE+ +EK E++ R+ + TE+ E++ A +E+E
Sbjct: 859 REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM---EAIQAQREEERTQAESA 915
Query: 877 -----------------------QDLLDRFQMLHNRAEDWEVK----------------- 896
++L D Q L +D +V+
Sbjct: 916 LCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975
Query: 897 --------AHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISS 948
A Q + ++++ E S+ ++ L+++VE L+ ++ ++ E ++
Sbjct: 976 AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE 1035
Query: 949 MAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVE 1008
+ + E EKA++ L + + L I Q+L++ + + E
Sbjct: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095
Query: 1009 LENVKSESDLLKKQ--------LSNERHTVKNLESLLATNRDKEFHSHLTSHE-KDTEIQ 1059
+ + ++ +LL+++ L+ E ++ LE+ T +++ + L + E K ++Q
Sbjct: 1096 QKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT--EQQLRASLWAQEAKAAQLQ 1153
Query: 1060 LLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQIST 1102
L L ++ + +A+ AQL + Y AL++ + +
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQ-AQLASLYSALQQALGS 1195
Score = 94.4 bits (233), Expect = 6e-19
Identities = 202/939 (21%), Positives = 385/939 (41%), Gaps = 197/939 (20%)
Query: 285 KDLEKRI--------RELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKE-- 334
++LEKR+ + +E E++ + ++ C+ L E++ QL H E
Sbjct: 71 QELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNT---QLRLHMEKA 127
Query: 335 --------EVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLE------LNLCQKEKE 380
E +E + A+ E+ RK S+ Q +E+ K L+ L+L ++
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQ-MEQEFFKGYLKGEHGRLLSLWREVVT 186
Query: 381 RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRD-RS 439
L +KS + + +L+ E RLS + + + +LT+ + R +G R D R
Sbjct: 187 FRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCL---RLTVGAQS-REPNGSGRMDGRE 242
Query: 440 PSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIH 499
P++L L +E K+ ER Q +IQ +S EK + +
Sbjct: 243 PAQLLLLLAKTQELE---KEAHERSQELIQLKSQGDL-------------EKAELQDRVT 286
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTA 559
+++ + Q+ E +EK ++ ++ V++L E + ++ +EA +A ++ +
Sbjct: 287 ELSALLTQSQKQNEDYEKMIKALRETVEIL--ETNHTELMEHEASLSRNAQEEKLSLQQV 344
Query: 560 PHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQ 619
+I +M +E + +A+ LE + S+F + + + + LT V
Sbjct: 345 IKDITQVMVEEGDN--------IAQGSGHENSLEL--DSSIFSQFDYQDADKALTLVRSV 394
Query: 620 LESEKY---ELKSKVLIMKETIESLENK----------LKVQAQKFSH----VAGDSSHQ 662
L + +L+ ++ +E + L+ + L+ + QK + +AG +
Sbjct: 395 LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL 454
Query: 663 KTEVNSLRIVNEQLQRSVDDYQHRLSIKRGEL--------------ESAQAQIKILEEKI 708
+ EV+SL E LQ++ ++ + +L + E +SAQ Q EE+
Sbjct: 455 QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ---KEEQQ 511
Query: 709 DELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQE--TVDEKTEKIANLQENLANKEK---- 762
+EL+L + E + + +G+ K+ + L E T+ E E ++L+ L +E+
Sbjct: 512 EELHLAVR---ERERLQEMLMGLEAKQSESLSELITLREALES-SHLEGELLRQEQTEVT 567
Query: 763 -AVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKEL--DEVGRSREIAFKE 819
A+A+ + I+E SS N LK + ++ + +L A ++ L D+VG
Sbjct: 568 AALARAEQSIAELSSSENTLKTEVA----DLRAAAVKLSALNEALALDKVG--------- 614
Query: 820 NRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDL 879
L L + ENQ + +EAA Q + ++ +A EK + L
Sbjct: 615 ---LNQQLLQLEEENQSVCSRMEAAEQARNALQVD--------------LAEAEKRREAL 657
Query: 880 LDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAH 939
++ L + + KA +A E + + R ++E E ++K++ E +
Sbjct: 658 WEKNTHLEAQLQ----KAEEAGAE----------LQADLRDIQEEKEEIQKKLSESRHQQ 703
Query: 940 HAYESQISSMAKAMSRLEEELRHQEDEKATVL--------------NDLSSLRELCIKLD 985
A +Q+ + + R EE L EK ++ D L E L
Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
Query: 986 SGKDIM------TQQLNS--------KNLEFERVVVELENVKSESDLLKKQLSNERHTVK 1031
S K+++ QQ NS ++ + V E ++ E LK +L ER +
Sbjct: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 1032 NLESLLA---TNRDKEFHSHL----TSHEKDTEIQLLKEKLTLSES--------KLTSQS 1076
A ++E + L +HEK E+ L+EK S L S
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEK--EVNQLREKWEKERSWHQQELAKALESLE 881
Query: 1077 RENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMR 1115
RE L ++ + QT+ +A++ Q ER + E A+ +M+
Sbjct: 882 REKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ 920
Score = 88.6 bits (218), Expect = 3e-17
Identities = 204/1001 (20%), Positives = 399/1001 (39%), Gaps = 123/1001 (12%)
Query: 28 ECLPLVEKLFSDLVHTTESLR-QSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELY 86
E L L+ + ++ E+LR Q + + E + A + + K N + + ++
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 87 LELMKLR---EHSDQHVKELKTSL---KKCARETA-DLKFLNNQYAHKLKLLEKESKAKN 139
EL K R EH V+E + L ++ RE D + N H+L LEK+ +
Sbjct: 1481 -ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
Query: 140 ERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPY----- 194
+ Q+Q+ KK+ + ++++E E + + +
Sbjct: 1540 SQRGQVQDL-----------KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV 1588
Query: 195 -IADLLQVADNRIQELQ---QEVHQLQE-------KLAMMESGVRDYSKQIELREREIER 243
+ L + R QELQ ++H L+ +L + V+ +QIE +R+ E
Sbjct: 1589 ALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH 1648
Query: 244 LSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTS 303
L+ L+ +L E ++ I + L+Q L +R REL ++
Sbjct: 1649 LTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQ---- 1704
Query: 304 EVVNLSNKNEKLCQELTEIDQLAQQLER----HKEEVLETADKELGEAKKEIKRKLSEMQ 359
L QE E + + +R H + +L +KE+ E ++E +L E++
Sbjct: 1705 -----------LMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEV-ECQQEHIHELQELK 1752
Query: 360 D-LEETMAKL-----QLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESF 413
D LE+ + L + L L Q+E+E ++++ L+ Q E ++Q L +++
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQE----IVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 414 --AVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQ-HIIQR 470
A+ +R LE + + + +R + D +E+ K+ LQ H Q
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
Query: 471 RSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDE-LQRMLERFEKYMEDIQSNVKLL 529
R + + GD +E +RE+++ L + ++ + ++ + + L
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAE----SREQEKALLALQQQCAEQAQEHEVETRAL 1924
Query: 530 TAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEA-L 588
+ + E +EL ALR ES + + + AL + KE L
Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHL 1984
Query: 589 REKLE---HIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL 645
E+ E +E + ++ L+ H + L ++ E++ + L +E ++ L+ L
Sbjct: 1985 LEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
Query: 646 KVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILE 705
+ ++ H Q+ E + + +++Q ++ + L +R E E I+ L
Sbjct: 2045 AQRDEELRH------QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE-----IRGLH 2093
Query: 706 EKIDELNLKMTSQDEEAHVMKKTIGVIDKE---KDFLQETVDEKTEKI----ANLQENLA 758
+ + EL L + +++E +++T + E ++E++ K+ LQ L
Sbjct: 2094 QSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELE 2153
Query: 759 NKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ---LDAAHKELDEVGRSREI 815
+ A+ Q + E L +L ++SL+ L A+ E D
Sbjct: 2154 RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD-------- 2205
Query: 816 AFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHK--YITEVSRWESLMAAKE 873
E +RLQD+L R ++ L A E+ SR + + EVS E+ +
Sbjct: 2206 --SEQQRLQDELELTRRALEKERLHSPGAT-STAELGSRGEQGVQLGEVSGVEAEPSPDG 2262
Query: 874 KENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQ 933
E Q R + L E+ + + + +R L ++ ERR L+ +
Sbjct: 2263 MEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK----------R 2312
Query: 934 EHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDL 974
E + A A +IS A A S +++ R Q++ A + +L
Sbjct: 2313 EAMRAAQAGSLEISK-ATASSPTQQDGRGQKNSDAKCVAEL 2352
Score = 86.7 bits (213), Expect = 1e-16
Identities = 201/974 (20%), Positives = 386/974 (39%), Gaps = 137/974 (14%)
Query: 22 RQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRE 81
+Q +T+ECL L + H +Q + ++ ++E+ L L+ S+E
Sbjct: 1550 KQLVTLECLALE----LEENHHKMECQQKLIKELEGQRETQRV--ALTHLTLDLEERSQE 1603
Query: 82 NNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK---ESKAK 138
++ L HS +EL+ ++ + ++ L Q H + LE+ E +
Sbjct: 1604 LQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663
Query: 139 NERIQQLQ----------EKNLHAVVQTPGGKKRSIAFRRQRMQ--IDEPVPPSEVSSYP 186
ERIQ L+ E++L + + + R + +RQ MQ +E PS+
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 187 VPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSV 246
+ ++ +L+ + ++ Q+ +H+LQE +E +Q++ R++ S+
Sbjct: 1724 LE-----HMKLILRDKEKEVECQQEHIHELQELKDQLE-------QQLQGLHRKVGETSL 1771
Query: 247 ALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKE-TVTSEV 305
L R +++ L+ + LQ+A RE E KE ++ S++
Sbjct: 1772 LL-SQREQEIVVLQQQ-----------------LQEA--------REQGELKEQSLQSQL 1805
Query: 306 VNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADK---ELGEAKKEIKRKLSEMQDLE 362
+ QEL + Q QQ + +E V E AD L +A +K + E+QD +
Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHK 1865
Query: 363 ETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTL 422
E +L+ EL + + + L + V DL EQEK L+ L
Sbjct: 1866 EQARRLEEELAVEGRRVQALEE---VLGDLR--AESREQEKALLA------------LQQ 1908
Query: 423 EVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREK 482
+ EH ++ R S L + + +ERD +ELE L R+ S S +E+
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQA--QAVLKERD---QELEAL------RAESQSSRHQEE 1957
Query: 483 SSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNE 542
++ R + + H + ++ Q +LE+ E ++++ L A D +
Sbjct: 1958 AARARAEALQEALGKAHAALQGKE--QHLLEQAE-LSRSLEASTATLQASLDACQAHSRQ 2014
Query: 543 AQEELSALRKE------STQTTAPHNIVSLMEKEKELALSDLRRIMAEKE-ALREKLEHI 595
+E L E Q +L ++++EL R + EK A R + I
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMI 2074
Query: 596 EEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHV 655
+E G+ E+ I L +L+ + + ++L ++ET + + ++A SH
Sbjct: 2075 QEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET----QQRNNLEALPHSHK 2130
Query: 656 AGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKM 715
Q +++SL +LQR ++ Q L +A+ EK +L L +
Sbjct: 2131 TSPMEEQSLKLDSL---EPRLQRELERLQ-------AALRQTEAREIEWREKAQDLALSL 2180
Query: 716 TSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECE 775
K ++ + + FLQ +V E+ + LQ+ L +A+ + ++
Sbjct: 2181 AQ-------TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGAT 2233
Query: 776 SS--VNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARE 833
S+ + E V E++ + + E + E + RL+ D + + R
Sbjct: 2234 STAELGSRGEQGVQLG-EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRH 2292
Query: 834 NQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDW 893
N ++ LE +E+ ++K + S S A QD R +
Sbjct: 2293 NVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD---------GRGQKN 2343
Query: 894 EVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKA- 952
AE + V L+ + ER+ ++ + + +E HH+ + ++A+A
Sbjct: 2344 SDAKCVAELQKEVVLLQ-AQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP 2402
Query: 953 -MSRLEEELRHQED 965
+ LE E R ++
Sbjct: 2403 EATVLEAETRRLDE 2416
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 145 bits (366), Expect = 2e-34
Identities = 230/990 (23%), Positives = 435/990 (43%), Gaps = 133/990 (13%)
Query: 195 IADLLQVADNRIQ---------ELQQEVHQLQEKLAMMES------GVRDYSKQI-ELRE 238
+ DLL+ IQ EL +HQLQEK ++ + +D KQ+ +
Sbjct: 304 VVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMM 363
Query: 239 REIERLSVALDGGRSPDVL-SLES-----RNKTNEKLIAHLNIQVDFLQQANKDLEKRIR 292
E ER +V + R D + +LE +NK + +Q+ F QQ + +E I
Sbjct: 364 TEKERSNVVIT--RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKF-QQVREQMEAEIA 420
Query: 293 ELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIK 352
L + + V N +N+ E ++ E+++L Q R E+ E K E E++
Sbjct: 421 HLKQENGILRDAVSNTTNQLES--KQSAELNKLRQDYARLVNELTEKTGKLQQE---EVQ 475
Query: 353 RKLSEMQDLEETMAKLQLELNLCQKE--------KERLSDELLVKSDLETVVHQLEQEKQ 404
+K + E+ +L+++L ++ ++R ++ + DL++ E E Q
Sbjct: 476 KK-----NAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQ 530
Query: 405 RLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERL 464
L K+ V+++QL E M+L ++R L ++ I E+ + K ++++
Sbjct: 531 SLHSKLTDTLVSKQQL--EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF 588
Query: 465 QHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQS 524
I ++ S S A E + +K +E + ERD L E+ ++DIQ+
Sbjct: 589 HSQIAAQT-SASVLAEELHKVIAEKDKQIKQTE-DSLASERDRLTSK----EEELKDIQN 642
Query: 525 NVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAE 584
LL AE KL L NE L K + + L+E++ + +S+ M E
Sbjct: 643 MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNK---MEE 699
Query: 585 KEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENK 644
+ L ++ + + KSE++K T V+ Q + E M++ I+ + K
Sbjct: 700 FKILNDQNKAL-------KSEVQKL---QTLVSEQPNKDVVEQ------MEKCIQEKDEK 743
Query: 645 LKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKIL 704
LK + + ++ E+N++R N L + V D L K+ + S + ++ L
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD----LKAKQNDQVSFASLVEEL 799
Query: 705 EEKIDELNLKMTSQDE--EAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEK 762
++ I E + K+ S +E EA ++K V +KEK TV + ++I L+E + N +
Sbjct: 800 KKVIHEKDGKIKSVEELLEAELLK----VANKEK-----TVQDLKQEIKALKEEIGNVQL 850
Query: 763 AVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRR 822
AQ + S+ V +L+ L ++ ++N+++ L+ K+L G+ + +EN
Sbjct: 851 EKAQQLSITSK----VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
Query: 823 LQDDLATMAREN-QEISL-----ELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKEN 876
L+ + +A+ N +E S ELE ++EKE R+ + E ES +++K +
Sbjct: 907 LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKER---ESDLSSKTQLL 963
Query: 877 QDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRH-----------LRERV 925
QD+ D ++ ++ E + + +Q + S ELL + +ER L++ V
Sbjct: 964 QDVQDENKLFKSQIEQLKQQNYQ-QASSFPPHEELLKVISEREKEISGLWNELDSLKDAV 1022
Query: 926 ELLEKEIQEHINAHHAYESQISSMAKAM-------SRLE--EELRHQEDEKATVLNDLSS 976
E K+ E A E + + K + S L E L E + + S
Sbjct: 1023 EHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1082
Query: 977 LRELCI---KLDSGKDIMT------QQLNSKNLEFERVVVELE-NVKSESDLLKKQLSNE 1026
E+ + KL ++ T ++ S E E ++ +L+ +V+ E + K ++
Sbjct: 1083 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1142
Query: 1027 RHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKV 1086
T+K ++S T+ ++E L S KD E L +E+ L E +L E + +V
Sbjct: 1143 HKTIKQMQSSF-TSSEQELE-RLRSENKDIE-NLRREREHL-EMELEKAEMERSTYVTEV 1198
Query: 1087 AQLQTDYDALKRQISTERYERERAIQEMRR 1116
+L+ + ++ TE+ ER++ ++ +
Sbjct: 1199 RELKAQLNETLTKLRTEQNERQKVAGDLHK 1228
Score = 106 bits (264), Expect = 1e-22
Identities = 203/954 (21%), Positives = 401/954 (42%), Gaps = 128/954 (13%)
Query: 1 MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKE 60
M T ER + I + D++G TL E +F + +H S ++++ +K ++
Sbjct: 362 MMTEKERSNVVITRMKDRIG---TLEKE-----HNVFQNKIHV--SYQETQQMQMKFQQV 411
Query: 61 SANFDFVLEPYKLENARL----SRENNELY----LELMKLREHSDQHVKELKTSLKKCAR 112
+ + K EN L S N+L EL KLR+ + V EL K +
Sbjct: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ 471
Query: 113 ETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNL--HAVVQTPGGKKRSIAFRRQR 170
E K Q A +LK+ +E++ + E +Q K H Q Q
Sbjct: 472 EEVQKKNAE-QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQ-------------QD 517
Query: 171 MQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDY 230
+Q +EV S D L+ ++ E +Q+ +E L M V+D
Sbjct: 518 LQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQ---VQDI 574
Query: 231 SKQIELREREIERLSVALDGGRSPDVLSLESRN---------KTNEKLIAHLNIQVDFLQ 281
+Q E + +I++ + S VL+ E K E +A ++ +
Sbjct: 575 LEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
Query: 282 QANKDLEKR---IRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLE 338
+ KD++ ++ ++ + + +E +++ EK+ Q + D + LE + +
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEIS 694
Query: 339 TADKE---LGEAKKEIKRKLSEMQDL--EETMAKLQLELNLCQKEKERLSDELL--VKSD 391
+E L + K +K ++ ++Q L E+ + ++ C +EK DE L V+
Sbjct: 695 NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEK----DEKLKTVEEL 750
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDR-SPSRLDTFLKGI 450
LET + Q+ +++ L+ + LT EV+ ++ K+ D+ S + L LK +
Sbjct: 751 LETGLIQVATKEEELN----AIRTENSSLTKEVQDLKA----KQNDQVSFASLVEELKKV 802
Query: 451 EEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQ-----ITRER 505
E+D K +E L + + + ++ + ++ N ++ + IT +
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKV 862
Query: 506 DELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNI-- 563
ELQ +L+ E+ M +++ ++ + + QEE +L K Q A HN+
Sbjct: 863 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL-KAHVQEVAQHNLKE 921
Query: 564 ---------VSLMEKEKELALSDLRRIMAEKEA-LREKLEHIEEVSLFGKSELEKTIEHL 613
+ ++ KEKE L L ++ E+E+ L K + +++V K + IE L
Sbjct: 922 ASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL-FKSQIEQL 980
Query: 614 TCVNHQLESE--KYELKSKVLIMKET-IESLENKLKVQAQKFSHVAGDSSHQKTEVNSLR 670
N+Q S +E KV+ +E I L N+L H ++ ++ +V ++
Sbjct: 981 KQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVE 1040
Query: 671 IVNEQLQR------------SVDDYQHRLSIKRGEL---ESAQAQIKILEEKI---DELN 712
+ +++ + S ++ H K E S ++K+LE K+ DE++
Sbjct: 1041 LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMH 1100
Query: 713 LKMTSQDEE-AHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMI 771
+ + E+ V+ +T G++ K LQ +V+++ K + + K + QM+
Sbjct: 1101 TLLQLECEKYKSVLAETEGILQK----LQRSVEQEENK---WKVKVDESHKTIKQMQSSF 1153
Query: 772 SECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQ------- 824
+ E + +L+ + +++I +LRR+ + EL++ R E R L+
Sbjct: 1154 TSSEQELERLR----SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETL 1209
Query: 825 DDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQD 878
L T E Q+++ +L A Q E ++S++ K + + E+ + E E+ +
Sbjct: 1210 TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1263
Score = 85.5 bits (210), Expect = 3e-16
Identities = 160/827 (19%), Positives = 342/827 (41%), Gaps = 115/827 (13%)
Query: 12 IRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLR---QSKLSAVKAEKESANFDFVL 68
+ +RL QL + V ++ D++ E+L+ Q S + A+ ++ L
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
Query: 69 EPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYA--- 125
E + ++ + ++ +K+++ E L+ L N+ A
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
Query: 126 HKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSY 185
H+L+ +++ K+++I+ L+E+ H + + F+ Q SEV
Sbjct: 666 HELEKMQQSVYVKDDKIRLLEEQLQHEI------SNKMEEFKILNDQ--NKALKSEVQKL 717
Query: 186 PVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESG-VRDYSKQIELREREIERL 244
+ P D+++ + IQE +++ ++E ++E+G ++ +K+ EL E
Sbjct: 718 QTLVSEQPN-KDVVEQMEKCIQEKDEKLKTVEE---LLETGLIQVATKEEELNAIRTENS 773
Query: 245 SVALD----GGRSPDVLSLESRNKTNEKLIAHLN---------IQVDFLQQANKDLEKRI 291
S+ + + D +S S + +K+I + ++ + L+ ANK EK +
Sbjct: 774 SLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK--EKTV 831
Query: 292 RELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEI 351
++L + + + E+ N+ + + +++ +L Q L + KEE + T L E +K++
Sbjct: 832 QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQEL-QNLLKGKEEQMNTMKAVLEEKEKDL 890
Query: 352 KRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVE 411
+QDL+E L+ + + + + +LE V+ + E E +
Sbjct: 891 ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK------- 943
Query: 412 SFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRR 471
RLE +K R+ S L+ +++E +K ++E+L+ Q
Sbjct: 944 ----------------RLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ--QNY 985
Query: 472 SCSTSYSAREK-SSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLT 530
++S+ E+ + EK EI + E D L+ +E K + Q V+ +
Sbjct: 986 QQASSFPPHEELLKVISEREK-----EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVE 1040
Query: 531 AERDKLSVLYNEAQEELSALRKESTQTTAPHNI-----VSLMEKEKELALSDLRRIMAEK 585
E ++ L+K + + P N+ + EK+ + ++ E
Sbjct: 1041 LEAKEV-------------LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-SEEV 1086
Query: 586 EALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKL 645
+ L KL+ +E+ + E EK +S E + + ++ ++E ENK
Sbjct: 1087 KVLEHKLKEADEMHTLLQLECEK-----------YKSVLAETEGILQKLQRSVEQEENKW 1135
Query: 646 KVQAQK----FSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQH-RLSIKRGELESAQAQ 700
KV+ + + + + E+ LR N+ ++ + +H + +++ E+E +
Sbjct: 1136 KVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYV 1195
Query: 701 IKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANK 760
++ E K +LN +T E + +K G + K + L E + K K A
Sbjct: 1196 TEVRELKA-QLNETLTKLRTEQNERQKVAGDLHKAQQSL-ELIQSKIVKAAG-------- 1245
Query: 761 EKAVAQMKIMISECESSVNQLKETL-VNRDREINSLRRQLDAAHKEL 806
+ V + + E ESS KET+ V+ ++ + L++ L A +++L
Sbjct: 1246 DTTVIENSDVSPETESSE---KETMSVSLNQTVTQLQQLLQAVNQQL 1289
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 145 bits (366), Expect = 2e-34
Identities = 218/1074 (20%), Positives = 441/1074 (41%), Gaps = 118/1074 (10%)
Query: 5 VERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANF 64
+E K + +RL+ + + E KL + + +L+ K EKE
Sbjct: 915 LEAKVKEMNERLED---EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 65 DFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQY 124
+ ++ E A L +L E L+E Q + +L+ K T L Q
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 125 AHKLKLLEKESKAKN--ERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPS-- 180
LE+E K + ER ++ E +L ++ + + Q+DE +
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES------IMDLENDKQQLDERLKKKDF 1085
Query: 181 EVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELRERE 240
E+++ D+ + LQ +++ELQ + +L+E+L + K RE
Sbjct: 1086 ELNALNARIEDEQALGSQLQ---KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Query: 241 IERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKET 300
+E +S L+ + +E K + Q+ +DLE+ ++ + T
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEF-----------QKMRRDLEEAT---LQHEAT 1188
Query: 301 VTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD 360
+ ++ +L +++ + ++ Q+LE+ K E D ++ IK K +
Sbjct: 1189 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN---- 1244
Query: 361 LEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQL 420
LE+ L+ ++N + + E + +DL + +L+ E LS++++ QL
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSV---NDLTSQRAKLQTENGELSRQLDEKEALISQL 1301
Query: 421 T---------LEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELE---RLQHII 468
T LE + +LE +K ++ L + + R+ Y++E E LQ ++
Sbjct: 1302 TRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Query: 469 QRRSCSTSY--SAREKSSIFRTPEKGDYNSEIHQITRERDE-----------LQRMLERF 515
+ + + + E +I RT E + ++ Q +E +E L++ R
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 516 EKYMEDIQSNVKLLTA--------ERDKLSVL------YNEAQEELSALRKESTQTTAPH 561
+ +ED+ +V+ A +R+ +L Y E+Q EL + +KE+ +
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE- 1480
Query: 562 NIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLE 621
+ ++ E +L L E + L+E++ + E G S KTI L V QLE
Sbjct: 1481 --LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ--LGSSG--KTIHELEKVRKQLE 1534
Query: 622 SEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNS-LRIVNEQLQRSV 680
+EK EL+S + + ++E E K+ +F+ + + + E + + R V
Sbjct: 1535 AEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVV 1594
Query: 681 DDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQ 740
D Q L + A K +E ++E+ ++++ + A +K + + Q
Sbjct: 1595 DSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1654
Query: 741 ETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLD 800
+D+ +L+EN+A E+ ++ + E + V Q + R R++
Sbjct: 1655 IQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE-----RSRKL-------- 1701
Query: 801 AAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYIT 860
A +EL E ++ +N L + M + ++ E+E AVQE + + K IT
Sbjct: 1702 -AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1760
Query: 861 EVSRWESLMAAKEKENQDLLDRFQMLHNRAE----DWEVKAHQAEGESSSVRLELLSIDT 916
+ ++MA + K+ QD + + E D + + +AE ++ L
Sbjct: 1761 DA----AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE------QIALKGGKK 1810
Query: 917 ERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSS 976
+ + L RV LE E++ + + M K+ R++E E+++ +L
Sbjct: 1811 QLQKLEARVRELENELEAEQKRN---AESVKGMRKSERRIKELTYQTEEDRKNLLRLQDL 1867
Query: 977 LRELCIKLDSGK---DIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNER 1027
+ +L +K+ + K + +Q N+ +F +V EL+ + +D+ + Q++ R
Sbjct: 1868 VDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921
Score = 138 bits (347), Expect = 3e-32
Identities = 205/960 (21%), Positives = 400/960 (41%), Gaps = 142/960 (14%)
Query: 205 RIQELQQEVHQLQEKLAMMESGVR--DYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+I+ L + + +E +M E R + ++ E R +E+E V+L ++ L+ +
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKN----DLQLQ 890
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
+ + +A + D L + LE +++E+ E E L+ K KL E +E+
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K EM L+E +AKL E Q+ ++
Sbjct: 951 KRDIDDLEL----TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA 1006
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE-RMRLEHGIKRRDRSPS 441
D+L + D V+ L + K +L ++V+ E L E + RM LE R+
Sbjct: 1007 LDDLQAEED---KVNTLTKAKVKLEQQVDDL---EGSLEQEKKVRMDLE-------RAKR 1053
Query: 442 RLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQI 501
+L+ LK +E + + ++L ++++ E N+ I
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDF----------------ELNALNARIEDE 1097
Query: 502 TRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPH 561
+LQ+ L+ + +E+++ ++ R K+ L ++ EL + + +
Sbjct: 1098 QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT 1157
Query: 562 NIVSLMEKEKELALSDLRRIMAE--------KEALREKLEHIEEVSLFGKSELEKTIEHL 613
++ M K++E +RR + E ALR+K H + V +EL + I++L
Sbjct: 1158 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK--HADSV-----AELGEQIDNL 1210
Query: 614 TCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVN 673
V +LE EK E K ++ + +E + K K +K D ++N R
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQI-IKAKANLEKMCRTLED------QMNEHRSKA 1263
Query: 674 EQLQRSVDD---YQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIG 730
E+ QRSV+D + +L + GEL + + L ++ L T Q E+ +K+ +
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED---LKRQLE 1320
Query: 731 VIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDR 790
K K+ L + L+E + +A A+++ ++S+ S V Q +
Sbjct: 1321 EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR-------- 1372
Query: 791 EINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEE 850
E D + R+ E+ + ++L L + ++ + + + K
Sbjct: 1373 -----------TKYETDAIQRTEELE-EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420
Query: 851 MKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLE 910
+++ + + +V R + AA +K+ ++ D+ +W+ K +++ E S + E
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRN-FDKI------LAEWKQKYEESQSELESSQKE 1473
Query: 911 LLSIDTERRHLR----ERVELLE------KEIQEHINAHHAYESQISSMAKAMSRLEEEL 960
S+ TE L+ E +E LE K +QE I+ Q+ S K + LE+
Sbjct: 1474 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS---DLTEQLGSSGKTIHELEKVR 1530
Query: 961 RHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLK 1020
+ E EK + + L E ++ + GK + Q LEF ++ E+E +E D
Sbjct: 1531 KQLEAEKMELQSALEE-AEASLEHEEGKILRAQ------LEFNQIKAEIERKLAEKDEEM 1583
Query: 1021 KQLS-NERHTVKNLE-SLLATNRDKE--------------------FHSHLTSHEKDTEI 1058
+Q N V +L+ SL A R + H++ + E ++
Sbjct: 1584 EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1643
Query: 1059 QLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQIS-----TERYERERAIQE 1113
+ L+ L ++ +L R N L+ +A ++ + L+ ++ E+ ER R + E
Sbjct: 1644 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703
Score = 114 bits (286), Expect = 4e-25
Identities = 157/898 (17%), Positives = 378/898 (42%), Gaps = 94/898 (10%)
Query: 235 ELREREIERLSVALDGGRSPDVLSLESRNKTNEK----LIAHLNIQVDFLQQANKDLEK- 289
E+R+ + R+ + +S VL+ K E+ L+ NI+ F+ N K
Sbjct: 775 EMRDERLSRIITRIQA-QSRGVLARMEYKKLLERRDSLLVIQWNIRA-FMGVKNWPWMKL 832
Query: 290 --RIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEA 347
+I+ L+++ E E+ ++ + +L + L + + ++LE +L+ E +
Sbjct: 833 YFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ----EKNDL 887
Query: 348 KKEIKRKLSEMQDLEETMA-----KLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQE 402
+ +++ + + D EE K+QLE + ++ ERL DE + ++L +LE E
Sbjct: 888 QLQVQAEQDNLADAEERCDQLIKNKIQLEAKV-KEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 403 KQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELE 462
L + ++ +T ++ E E+ E+ +K + LD + + +E+ ++ +
Sbjct: 947 CSELKRDIDDLELTLAKV--EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 463 RLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDI 522
+ +Q + + K + + + D + Q + R +L+R + E ++
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVD--DLEGSLEQEKKVRMDLERAKRKLEGDLKLT 1062
Query: 523 QSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIM 582
Q ++ L ++ +L + EL+AL A + + KE + + +L +
Sbjct: 1063 QESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL 1122
Query: 583 AEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKV-LIMKETIESL 641
+ R K+E + +S+L + +E ++ +LE ++ + K E
Sbjct: 1123 EAERTARAKVEKL-------RSDLSRELEE---ISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 642 ENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQI 701
+ + ++ H A ++ +K +S+ + EQ+ L + +LE +++
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN--------LQRVKQKLEKEKSEF 1224
Query: 702 KILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKE 761
K+ ++D++ M + ++K ++ + + + +E + +L A +
Sbjct: 1225 KL---ELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQ 1281
Query: 762 KAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENR 821
++ + E E+ ++QL + +++ L+RQL+ K + + + + A +
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD 1341
Query: 822 RLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLD 881
L++ + E + K E++ + K +EV++W + K D +
Sbjct: 1342 LLRE--------------QYEEETEAKAELQRVLSKANSEVAQWRT------KYETDAIQ 1381
Query: 882 RFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHA 941
R + L + + +AE +V + S++ + L+ +E L +++ A A
Sbjct: 1382 RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1441
Query: 942 YESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLE 1001
+ + + K ++ +++ + E + + SL KL + + + L +
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET---- 1497
Query: 1002 FERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLL 1061
F+R E +N++ E L +QL + T+ LE + K E + +
Sbjct: 1498 FKR---ENKNLQEEISDLTEQLGSSGKTIHELEKV----------------RKQLEAEKM 1538
Query: 1062 KEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRHGL 1119
+ + L E++ + + E +LRA Q +++ +K +I + E++ +++ +R+ L
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRA-----QLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1591
Score = 102 bits (255), Expect = 2e-21
Identities = 174/900 (19%), Positives = 353/900 (39%), Gaps = 139/900 (15%)
Query: 35 KLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLRE 94
KL DL T ES+ + + ++ DF L NAR+ E L +L K +
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL---NARIEDEQ-ALGSQLQKKLK 1109
Query: 95 HSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVV 154
++EL+ L+ A TA K KL S+ E ++L+E V
Sbjct: 1110 ELQARIEELEEELE--AERTARAKVE--------KLRSDLSRELEEISERLEEAGGATSV 1159
Query: 155 QTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADN---------- 204
Q KKR F++ R ++E E ++ + + +A+L + DN
Sbjct: 1160 QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1219
Query: 205 ------------------------------------------RIQELQQEVHQLQEKLAM 222
+ +E Q+ V+ L + A
Sbjct: 1220 EKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAK 1279
Query: 223 MESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQ 282
+++ + S+Q++ +E I +L+ G+ LE + E+ + N LQ
Sbjct: 1280 LQTENGELSRQLDEKEALISQLT----RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQS 1335
Query: 283 ANKDLEKRIRELMETKETVTSEVVN-LSNKNEKLCQELTEIDQLAQQLERHKEEVLETAD 341
A D + +RE E + +E+ LS N ++ Q T+ + A Q EE +
Sbjct: 1336 ARHDCDL-LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1394
Query: 342 KELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLV----KSDLETVVH 397
+ L EA++ ++ ++ LE+T +LQ E+ + ER + + + + ++
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454
Query: 398 QLEQEKQRLSKKVESFAVTERQLTLEVERMR------LEHGIKRRDRSPSRLDTFLKGIE 451
+ +Q+ + ++ES R L+ E+ +++ LEH ++ R L + +
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH-LETFKRENKNLQEEISDLT 1513
Query: 452 E----------ERDYYKKELE----RLQHIIQRRSCSTSYSAREKSSIFRTP-EKGDYNS 496
E E + +K+LE LQ ++ S + E+ I R E +
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH---EEGKILRAQLEFNQIKA 1570
Query: 497 EIHQITRERDELQRMLERFE-KYMEDIQSNVKLLTAERD-------KLSVLYNEAQEELS 548
EI + E+DE +R + ++ +Q+++ T R+ K+ NE + +LS
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS 1630
Query: 549 ALRKESTQTTAPHNIVSLMEKEKELALSDLRR------------------IMAEKEALRE 590
+ + + + + K+ ++ L D R + AE E LR
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 591 KLEHIEEVSLFGKSELEKTIEHLTCVNHQ----------LESEKYELKSKVLIMKETIES 640
+E E + EL +T E + ++ Q ++++ +L+++V + +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRN 1750
Query: 641 LENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRL-SIKRGELESAQA 699
E K K + +A + ++ L + + +++++ D QHRL ++ L+ +
Sbjct: 1751 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKK 1810
Query: 700 QIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLAN 759
Q++ LE ++ EL ++ ++ + K + ++ L +E + + LQ+ +
Sbjct: 1811 QLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Query: 760 KEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEV-GRSREIAFK 818
+ V K E E N E++ + D A +++++ +SR+I K
Sbjct: 1871 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 144 bits (364), Expect = 4e-34
Identities = 256/1220 (20%), Positives = 502/1220 (41%), Gaps = 253/1220 (20%)
Query: 23 QTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKA-EKESANFDFVLEPYKLENARLSRE 81
Q+ +VE + +++ SD + E +R S L+ + +++ +E + E + LS+E
Sbjct: 380 QSASVEEVFRLQQALSDAEN--EIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQE 437
Query: 82 NNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNER 141
EL + L+KL + +K T E DL+ +L E +
Sbjct: 438 KEELQMSLLKLNNEYEV-IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAE 496
Query: 142 IQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQV 201
I++L +N A K I + Q ++
Sbjct: 497 IEELDRQNQEAT-------KHMILIKDQ-------------------------LSKQQNE 524
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLES 261
D+ I +L+Q+++ ++++ +E D +K++++++ ++ + VAL+ L
Sbjct: 525 GDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN--------DLHL 576
Query: 262 RNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTE 321
+ E + +L Q++ Q++N ++K E +E KE + LS +L Q L +
Sbjct: 577 TKQKLEDKVENLVDQLNKSQESNVSIQK---ENLELKEHIRQNEEELSRIRNELMQSLNQ 633
Query: 322 IDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKER 381
K+ +L+ + E+ + +K+ LSE++ L E + K+ ++ +
Sbjct: 634 DSN-----SNFKDTLLKEREAEV----RNLKQNLSELEQLNENLKKVAFDV--------K 676
Query: 382 LSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLE----VERMRLEHGIKRRD 437
+ +E LV + E V HQLE+ QL+LE VE +++E G
Sbjct: 677 MENEKLVLA-CEDVRHQLEE-----------CLAGNNQLSLEKNTIVETLKMEKG----- 719
Query: 438 RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSE 497
+ L K + EE + Y+K +E L + R+ +TS E + + +K D E
Sbjct: 720 EIEAELCWAKKRLLEEANKYEKTIEELSNA---RNLNTSALQLEHEHLIKLNQKKDM--E 774
Query: 498 IHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKES--- 554
I ++ + +++ + + + K LT +K + + +E S L++E
Sbjct: 775 IAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKY 834
Query: 555 TQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHI-EEVSLFGKSELEKTIEHL 613
+Q + I+ +EK+ +L ++ E L+E+LE + EE S KT++ +
Sbjct: 835 SQALRKNEILRQTIEEKDRSLGSMKE---ENNHLQEELERLREEQSRTAPVADPKTLDSV 891
Query: 614 TCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVN 673
T +L SE +L + ++E I+ + ++ Q Q + QK E++ R +
Sbjct: 892 T----ELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947
Query: 674 EQ------------------LQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKM 715
EQ LQ++++ + +L +R ++++ + I E K+ LN++
Sbjct: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDI-FQETKVQSLNIEN 1006
Query: 716 TSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECE 775
S E H + K E + L + + E+ +I L E + K + Q+ +
Sbjct: 1007 GS---EKHDLSKA------ETERLVKGIKERELEIKLLNEKNISLTKQIDQLS------K 1051
Query: 776 SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQ 835
V +L + + +D EI +L H + ++++ + LQ L A E +
Sbjct: 1052 DEVGKLTQIIQQKDLEIQAL-------HARISSTSHTQDVVY-----LQQQLQAYAMERE 1099
Query: 836 EISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQM---------L 886
++ L +E +K+ HK + V+ E+ + + EN+ L RF+ +
Sbjct: 1100 KVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETI 1159
Query: 887 HN-----RAEDWEVKA------------------HQAEGESSSVRLELLSIDTERRHLRE 923
N R +D E+ A ++A G +S+ ELL ER L++
Sbjct: 1160 QNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ---ERDKLKQ 1216
Query: 924 RVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLS-------- 975
+V+ +E+ Q+ + + + + + + + +L+ ++ D + + D +
Sbjct: 1217 QVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQ 1276
Query: 976 -----------------SLRELCIKLDS--GK-DIMTQQLNSKNLEFERVVVELENVKSE 1015
S+ +LC D GK DI++ QL+S +L + L KSE
Sbjct: 1277 NETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE 1336
Query: 1016 -----SDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTS-------------HEK-DT 1056
S+LL+++L R K+L+ AT R + ++H S HE+ D+
Sbjct: 1337 VLSESSELLQQELEELR---KSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393
Query: 1057 EIQLLKEK---------------------LTLSESKLTSQSRENTMLRAKVAQLQTDYDA 1095
EI+ LKEK L S T++ EN +LR V L+
Sbjct: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI 1453
Query: 1096 LKRQISTERYERERAIQEMR 1115
L+ I + E E+ ++ R
Sbjct: 1454 LEMDIGKLKGENEKIVETYR 1473
Score = 134 bits (336), Expect = 6e-31
Identities = 218/982 (22%), Positives = 427/982 (43%), Gaps = 142/982 (14%)
Query: 206 IQELQQEVHQLQEKLAMMESGV--RDYSKQIELRER----EIERLSVALDGGRSPDVLSL 259
+ + ++ + +L+ L SGV D SK E+++ +IE++ + + L
Sbjct: 258 LSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVE------STKKMEQL 311
Query: 260 ESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQEL 319
E + K K ++ D L++ + L R++ME E + E L K +
Sbjct: 312 EDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTM 371
Query: 320 TEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQD--LEETMAKLQLELNLCQK 377
TE +++ Q EEV + L +A+ EI R S QD L E KL++ + + +K
Sbjct: 372 TEKERILAQ-SASVEEVFR-LQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEK 429
Query: 378 EKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRD 437
EK LS E K +L+ + +L E + ++S A + L E+ +RL K ++
Sbjct: 430 EKSLLSQE---KEELQMSLLKLNNEYE----VIKSTATRDISLDSELHDLRLNLEAKEQE 482
Query: 438 --RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYN 495
+S S +T + IEE ++ E +H+I + S E SI + K D N
Sbjct: 483 LNQSISEKETLIAEIEE---LDRQNQEATKHMILIKD-QLSKQQNEGDSII-SKLKQDLN 537
Query: 496 SE---IHQ-------ITRERDELQRMLERFEKYMEDI----------------------Q 523
E +HQ IT+E D + L + E + D+ +
Sbjct: 538 DEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQE 597
Query: 524 SNVKLLTAERDKLSVLYNEAQEELSALRKESTQT---TAPHNIVSLMEKEKELALSDLRR 580
SNV + E +L + +EELS +R E Q+ + N + KE+E + +L++
Sbjct: 598 SNVS-IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQ 656
Query: 581 IMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLE-----SEKYELKSKVLIMK 635
++E E L E L ++V+ K E EK + V HQLE + + L+ ++
Sbjct: 657 NLSELEQLNENL---KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVET 713
Query: 636 ETIESLENKLKVQAQKFSHVAGDSSHQKT--EVNSLRIVNEQLQRSVDDYQHRLSIKRGE 693
+E E + ++ K + + ++KT E+++ R +N + ++ +L+ K+ +
Sbjct: 714 LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK-D 772
Query: 694 LESAQAQIKILEEKIDELNLK--MTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIA 751
+E A+ + I + D K ++S EE K+ +I+K++ F +++ E+ +
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEE---QKQLTQLINKKEIF----IEKLKERSS 825
Query: 752 NLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEV-- 809
LQE L +A+ + +I L++T+ +DR + S++ + + +EL+ +
Sbjct: 826 KLQEELDKYSQALRKNEI-----------LRQTIEEKDRSLGSMKEENNHLQEELERLRE 874
Query: 810 GRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITE---VSRWE 866
+SR + + L D + +A E +++ ++E E + + H+ I E S+ +
Sbjct: 875 EQSRTAPVADPKTL-DSVTELASEVSQLN-----TIKEHLEEEIKHHQKIIEDQNQSKMQ 928
Query: 867 SLMAAKEKENQDLLDRFQMLHNR----------AEDWEVKAHQAEGESSSVRL--ELLSI 914
L + +E++ + +D F+ H + +D E+K+ Q E +L E I
Sbjct: 929 LLQSLQEQKKE--MDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDI 986
Query: 915 DTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDL 974
T+ + + ++ I+ H +++ + K + E E++ ++ ++ +
Sbjct: 987 QTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQI 1046
Query: 975 SSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKNLE 1034
L K + GK +TQ + K+LE + + + + D++ Q + + ++ +
Sbjct: 1047 DQLS----KDEVGK--LTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREK 1100
Query: 1035 SLLATNRDKEFHSHL-TSHEKDTEIQLLKE----KLTLSESKLTS--QSRENTMLRAKVA 1087
N +SHL T + K +I KE KL KL++ +S M R +
Sbjct: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQ 1160
Query: 1088 QL-------QTDYDALKRQIST 1102
L + DAL ++ T
Sbjct: 1161 NLSRIIREKDIEIDALSQKCQT 1182
Score = 84.7 bits (208), Expect = 4e-16
Identities = 128/631 (20%), Positives = 265/631 (41%), Gaps = 87/631 (13%)
Query: 201 VADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLE 260
V N+ +EL QE +L++++ ME + ++ + E +L L ++ ++ +
Sbjct: 1199 VNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSD 1258
Query: 261 SRNKTNEKLIAHLNIQVDF--LQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQE 318
+ +K +QVD+ L Q+ + E +++ + V + L N + L
Sbjct: 1259 NNSK----------LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLL--- 1305
Query: 319 LTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEM--QDLEETMAKLQLE---LN 373
L ++D ++ QL ++A+ L +K E+ + SE+ Q+LEE LQ + +
Sbjct: 1306 LGKLDIISPQLSSASLLTPQSAEC-LRASKSEVLSESSELLQQELEELRKSLQEKDATIR 1364
Query: 374 LCQKEKERLSDELLVKSDLETVVH-QLEQEKQRLSKKVESFA--VTERQLTLEVERMRL- 429
Q+ RLSD + S+LE H Q + E ++L +K + + E+ L ++ + +L
Sbjct: 1365 TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424
Query: 430 --EHGIKRRDRSPSRLDTFLKGIEE-----ERDYYKKELERLQHIIQRRSCSTSYSAREK 482
+ L + ++E E D K + E + + R T Y A ++
Sbjct: 1425 SSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQE 1484
Query: 483 SSIFRTPEKGDYNSEIHQITRERD-ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYN 541
+ N + + RE++ E M E+ + + ++ + T E ++L
Sbjct: 1485 T-----------NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVK 1533
Query: 542 EAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLF 601
QE+ ++E Q V L K+K++ E AL+ +++ + +
Sbjct: 1534 SMQEKTVVFQQERDQ-------VMLALKQKQM----------ENTALQNEVQRLRDKEFR 1576
Query: 602 GKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSH 661
ELE+ NH LESE + L ++ L K+ V +K
Sbjct: 1577 SNQELER------LRNHLLESED-SYTREALAAEDREAKLRKKVTVLEEKL--------- 1620
Query: 662 QKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEE 721
+ N++ + Q V+ Q +L++ + + Q+ + +E++ + L +
Sbjct: 1621 -VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSL------ 1673
Query: 722 AHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECES---SV 778
A++ +EK ++++ + IA ++N N E V ++ + E + S
Sbjct: 1674 ANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSA 1733
Query: 779 NQLKETLVNRDREINSLRRQLDAAHKELDEV 809
++L E L ++ +I L+RQ + + LD+V
Sbjct: 1734 SRLTEQLDVKEEQIEELKRQNELRQEMLDDV 1764
Score = 75.5 bits (184), Expect = 3e-13
Identities = 122/628 (19%), Positives = 263/628 (41%), Gaps = 102/628 (16%)
Query: 520 EDIQSNVKLLTAERDKLSVLYNEAQEELSALRKE-STQTTAPHNIVSLMEKEKELALSDL 578
++I++ +L +E ++L L + +E+ A + Q+T+ N L +KE E++
Sbjct: 55 KEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRN--QLQQKEVEISHLKA 112
Query: 579 RRIMAEKEALREKLEHIEEVSLFG------KSELEKTIEHLTCVNHQLESEKYELKSKVL 632
R+I + + L+ + S G S I H H + + ++ S
Sbjct: 113 RQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISS-- 170
Query: 633 IMKETIESLEN---KLKVQAQKFSHVAGDSSHQKTE----------VNSLRIVNEQLQRS 679
++ I L N +L+ + + H+A S Q T+ N ++ + + +
Sbjct: 171 --QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQE 228
Query: 680 VDDYQHRLSI---------------KRGELESAQAQIKILEEKIDELNLKMTSQD-EEAH 723
+DD+QH +S+ R EL + +I+ LE + + + D + +
Sbjct: 229 IDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIY 288
Query: 724 VMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKE 783
M+KTI V+ EK + +++ +KI ++ + L++ E ++ + Q+ E
Sbjct: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348
Query: 784 TLVNRDREINSLRRQLDAAHKELDEVGR--SREIAFKENRRLQDDLATMARENQEISL-- 839
N E + L+ + E R ++ + +E RLQ L+ E +S
Sbjct: 349 ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLN 408
Query: 840 ELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQ 899
+ + ++ ++K R+ EV E + ++EKE +L L+N ++EV
Sbjct: 409 QDNSLAEDNLKLKMRI-----EVLEKEKSLLSQEKE--ELQMSLLKLNN---EYEVIKST 458
Query: 900 AEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSM-------AKA 952
A + +S+D+E LR +E E+E+ + I+ ++I + K
Sbjct: 459 ATRD--------ISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510
Query: 953 MSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENV 1012
M ++++L Q++E ++++ L Q LN + ++ + ++
Sbjct: 511 MILIKDQLSKQQNEGDSIISKLK-----------------QDLNDEKKRVHQLEDDKMDI 553
Query: 1013 KSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKL 1072
E D+ K++L ++S +A N HLT + + +++ L ++L S+
Sbjct: 554 TKELDVQKEKL---------IQSEVALN-----DLHLTKQKLEDKVENLVDQLNKSQESN 599
Query: 1073 TSQSRENTMLRAKVAQLQTDYDALKRQI 1100
S +EN L+ + Q + + ++ ++
Sbjct: 600 VSIQKENLELKEHIRQNEEELSRIRNEL 627
Score = 56.2 bits (134), Expect = 2e-07
Identities = 103/546 (18%), Positives = 222/546 (40%), Gaps = 69/546 (12%)
Query: 18 QLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENAR 77
QL LT + + S+++ + L Q +L ++ K D + + N R
Sbjct: 1315 QLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELR--KSLQEKDATIRTLQENNHR 1372
Query: 78 LS-----------RENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAH 126
LS +E+ + E+ +L+E D K LK ++ L N + +
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTN 1432
Query: 127 KLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYP 186
K+ E++ + + L+E+ L +++ GK + + +I E E + Y
Sbjct: 1433 KVN----ENELLRQAVTNLKERIL--ILEMDIGKLKG-----ENEKIVETYRGKE-TEYQ 1480
Query: 187 VPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSV 246
Q + + +L+ + ++++ ++ L E G Q+ + ++ +V
Sbjct: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
Query: 247 ALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVV 306
R +L+L+ + N L + D ++N++LE+ L+E++++ T E +
Sbjct: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Query: 307 NLSNKNEKLCQELTEID---------------QLAQQLERHKEEVLETADKELGEAKKEI 351
++ KL +++T ++ Q + Q+E +E+ L K+ E ++
Sbjct: 1601 AAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQ-LNVVSKQRDETALQL 1659
Query: 352 KRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVE 411
+++ ++A LQ+ L Q+E++ + L K + ++ + ++ + L KV
Sbjct: 1660 SVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQ--KQLIAEWKKNAENLEGKVI 1717
Query: 412 SFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHI---I 468
S Q L+ L+ S SRL L EE+ + K++ E Q + +
Sbjct: 1718 SL-----QECLDEANAALD--------SASRLTEQLDVKEEQIEELKRQNELRQEMLDDV 1764
Query: 469 QRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRML--------ERFEKYME 520
Q++ S + S+ K + + + + H +R E+ R++ E E+
Sbjct: 1765 QKKLMSLANSSEGK--VDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFH 1822
Query: 521 DIQSNV 526
D Q V
Sbjct: 1823 DDQGGV 1828
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 144 bits (362), Expect = 6e-34
Identities = 198/1002 (19%), Positives = 406/1002 (40%), Gaps = 143/1002 (14%)
Query: 35 KLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLRE 94
KL DL T ES+ + ++ E++ +F + +N+++ E L L+L K +
Sbjct: 1056 KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ---QNSKIEDEQ-VLALQLQKKLK 1111
Query: 95 HSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVV 154
+ ++EL+ L+ A TA K KL S+ E ++L+E V
Sbjct: 1112 ENQARIEELEEELE--AERTARAKVE--------KLRSDLSRELEEISERLEEAGGATSV 1161
Query: 155 QTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVH 214
Q KKR F++ R ++E E ++ + + +A+L + DN +Q ++Q++
Sbjct: 1162 QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN-LQRVKQKLE 1220
Query: 215 QLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLN 274
+ + + + V +QI + +E++S L+
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE------------------------- 1255
Query: 275 IQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKE 334
QAN + ++ E + T++ L +N +L ++L E + L QL R K
Sbjct: 1256 ------DQAN-EYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKL 1308
Query: 335 EVLETADKELGEAKKEIKRKLSEMQDLEETMAK-LQLELNLCQKEKERLSDELLVKSDLE 393
+ + ++KR+L E + +A LQ + C +E+ +E K++L+
Sbjct: 1309 SYTQQME--------DLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360
Query: 394 TVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEE 453
V+ + E + K E+ A+ +R LE + +L ++ + + ++ +E+
Sbjct: 1361 RVLSKANSEVAQWRTKYETDAI-QRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKT 1419
Query: 454 RDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLE 513
+ + E+E L ++R + + + +++ + + E ++ E
Sbjct: 1420 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA----------------EWKQKYE 1463
Query: 514 RFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKEL 573
+ +E Q + L+ E KL Y E+ E L ++E+ K +
Sbjct: 1464 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN--------------KNLQE 1509
Query: 574 ALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLI 633
+SDL + E K + L V QLE EK EL+S +
Sbjct: 1510 EISDLTEQLGEGG---------------------KNVHELEKVRKQLEVEKLELQSALEE 1548
Query: 634 MKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNS-LRIVNEQLQRSVDDYQHRLSIKRG 692
+ ++E E K+ +F+ + + + E + + QR VD Q L +
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608
Query: 693 ELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIAN 752
K +E ++E+ ++++ + A +K + + Q +D+ +
Sbjct: 1609 SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668
Query: 753 LQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRS 812
L+EN+A E+ ++ + E + V Q + R R++ A +EL E
Sbjct: 1669 LKENIAIVERRNNLLQAELEELRAVVEQTE-----RSRKL---------AEQELIETSER 1714
Query: 813 REIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAK 872
++ +N L + M + ++ E+E AVQE + + K IT+ ++MA +
Sbjct: 1715 VQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDA----AMMAEE 1770
Query: 873 EKENQDLLDRFQMLHNRAE----DWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELL 928
K+ QD + + E D + + +AE ++ L + + L RV L
Sbjct: 1771 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE------QIALKGGKKQLQKLEARVREL 1824
Query: 929 EKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGK 988
E E++ + + M K+ R++E E++K +L + +L +K+ + K
Sbjct: 1825 EGELEAEQKRN---AESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYK 1881
Query: 989 ---DIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNER 1027
+ +Q N+ +F +V EL+ + +D+ + Q++ R
Sbjct: 1882 RQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1923
Score = 140 bits (353), Expect = 7e-33
Identities = 210/960 (21%), Positives = 409/960 (42%), Gaps = 154/960 (16%)
Query: 208 ELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNE 267
E ++E+ ++E+ +++ ++ E R +E+E V+L ++ L+ + + +
Sbjct: 846 ETEKEMATMKEEFGR----IKETLEKSEARRKELEEKMVSLLQEKN----DLQLQVQAEQ 897
Query: 268 KLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQ 327
+ + D L + LE +++E+ E E L+ K KL E +E+ +
Sbjct: 898 DNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDID 957
Query: 328 QLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELL 387
LE L +KE + ++K EM L+E +AKL E Q+ ++ D+L
Sbjct: 958 DLEL----TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1013
Query: 388 VKSDLETVVHQLEQEKQRLSKKV---ESFAVTERQLTLEVER--MRLEHGIKRRDRSPSR 442
V+ D V+ L + K +L ++V E E+++ +++ER +LE +K S
Sbjct: 1014 VEED---KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1070
Query: 443 LDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQIT 502
L+ +EE+ KKE + Q NS+I
Sbjct: 1071 LENDKLQLEEK--LKKKEFDINQQ----------------------------NSKIEDEQ 1100
Query: 503 RERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHN 562
+LQ+ L+ + +E+++ ++ R K+ L ++ EL + + + +
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160
Query: 563 IVSLMEKEKELALSDLRRIMAE--------KEALREKLEHIEEVSLFGKSELEKTIEHLT 614
+ M K++E +RR + E ALR+K H + V +EL + I++L
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK--HADSV-----AELGEQIDNLQ 1213
Query: 615 CVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNE 674
V +LE EK E K ++ + +E + K K +K S D + N R+ E
Sbjct: 1214 RVKQKLEKEKSEFKLELDDVTSNMEQI-IKAKANLEKVSRTLED------QANEYRVKLE 1266
Query: 675 QLQRSVDDY---QHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGV 731
+ QRS++D+ + +L + GEL Q++ E I +L S ++ +K+ +
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGEL---ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 732 IDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDRE 791
K K+ L + L+E + +A A+++ ++S+ S V Q + E
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY-----E 1378
Query: 792 INSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQE-ISLELEAAVQEKEE 850
++++R +EL+E + K +RLQD A E E ++ + + + K
Sbjct: 1379 TDAIQRT-----EELEEAKK------KLAQRLQD-----AEEAVEAVNAKCSSLEKTKHR 1422
Query: 851 MKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLE 910
+++ + + +V R + AA +K+ ++ D+ +W+ K +++ E S + E
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRN-FDKI------LAEWKQKYEESQSELESSQKE 1475
Query: 911 LLSIDTERRHLR----ERVELLE------KEIQEHINAHHAYESQISSMAKAMSRLEEEL 960
S+ TE L+ E +E LE K +QE I+ Q+ K + LE+
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS---DLTEQLGEGGKNVHELEKVR 1532
Query: 961 RHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLK 1020
+ E EK + + L E ++ + GK + Q LEF ++ E+E +E D
Sbjct: 1533 KQLEVEKLELQSALEE-AEASLEHEEGKILRAQ------LEFNQIKAEIERKLAEKDEEM 1585
Query: 1021 KQLS-NERHTVKNLE-SLLATNRDKE--------------------FHSHLTSHEKDTEI 1058
+Q N + V +L+ SL A R + H++ + E ++
Sbjct: 1586 EQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV 1645
Query: 1059 QLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQIS-----TERYERERAIQE 1113
+ L+ L ++ +L R N L+ +A ++ + L+ ++ E+ ER R + E
Sbjct: 1646 KSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1705
Score = 107 bits (268), Expect = 5e-23
Identities = 168/808 (20%), Positives = 337/808 (41%), Gaps = 101/808 (12%)
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIE 451
++ ++ E EK+ + K E + E E R LE K + D L+ ++
Sbjct: 838 IKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEE--KMVSLLQEKNDLQLQ-VQ 894
Query: 452 EERDYYKKELERLQHIIQRR--------SCSTSYSAREKSSIFRTPEKGDYNSEIHQITR 503
E+D ER +I+ + + E+ + T +K E ++ +
Sbjct: 895 AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKK 954
Query: 504 ERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNI 563
+ D+L+ L + EK ++ VK LT E L + + +E AL++ Q +
Sbjct: 955 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQV 1014
Query: 564 VSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESE 623
E++K +LS K L ++++ +E G E EK V LE
Sbjct: 1015 ----EEDKVNSLSK------SKVKLEQQVDDLE-----GSLEQEKK------VRMDLERA 1053
Query: 624 KYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDY 683
K +L+ + + +E+I LEN +K D + Q +++ +++ QLQ+ + +
Sbjct: 1054 KRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKEN 1113
Query: 684 QHRLSIKRGELES---AQAQIKILEEKIDELNLKMTSQDEEA--------HVMKKTIGVI 732
Q R+ ELE+ A+A+++ L + +++ + EEA + KK
Sbjct: 1114 QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEF 1173
Query: 733 DKEKDFLQE------------------TVDEKTEKIANLQENLANKEKAVAQMKIMISEC 774
K + L+E +V E E+I NLQ EK ++ K+ + +
Sbjct: 1174 QKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Query: 775 ESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMAREN 834
S++ Q+ + N ++ +L Q + +L+E RS + +LQ + +AR+
Sbjct: 1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQL 1293
Query: 835 QE----ISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQD---LLDRFQMLH 887
+E IS + ++M+ + E +L A + D L ++++
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET 1353
Query: 888 NRAEDWEVKAHQAEGESSSVRLELLSIDTER-RHLRERVELLEKEIQEHINAHHAYESQI 946
+ + +A E + R + + +R L E + L + +Q+ A A ++
Sbjct: 1354 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413
Query: 947 SSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVV 1006
SS+ K RL+ E+ ED ++ D+ LD + + L ++E
Sbjct: 1414 SSLEKTKHRLQNEI---ED----LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1466
Query: 1007 VELENVKSESDLLKKQLSNERH----TVKNLESLLATNRD-KEFHSHLTS---------H 1052
ELE+ + E+ L +L ++ ++++LE+ N++ +E S LT H
Sbjct: 1467 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH 1526
Query: 1053 E-----KDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYER 1107
E K E++ L+ + L E++ + + E +LRA Q +++ +K +I + E+
Sbjct: 1527 ELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRA-----QLEFNQIKAEIERKLAEK 1581
Query: 1108 ERAIQEMRR-HGLATPPLSSTLRSPSHS 1134
+ +++ +R H L ++L + + S
Sbjct: 1582 DEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Score = 94.0 bits (232), Expect = 7e-19
Identities = 147/800 (18%), Positives = 317/800 (39%), Gaps = 114/800 (14%)
Query: 39 DLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQ 98
+L T ++ Q + EK S + Y+++ R N+ + KL+ + +
Sbjct: 1229 ELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Query: 99 HVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPG 158
++L+ ++ T Q + LE+E KAKN LQ +
Sbjct: 1289 LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ 1348
Query: 159 GKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE 218
++ + A + +Q SEV+ + Y D +Q R +EL++ +L +
Sbjct: 1349 YEEETEA--KAELQRVLSKANSEVAQWRT-----KYETDAIQ----RTEELEEAKKKLAQ 1397
Query: 219 KLAMMESGVRDYSKQIELRER-------EIERLSVALDGGRSPDVLSLESRNKTNEKLIA 271
+L E V + + E+ EIE L V ++ + +L+ + + +K++A
Sbjct: 1398 RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA-AAALDKKQRNFDKILA 1456
Query: 272 HLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLER 331
+ + Q + +K R L ++E+ L N E + L ++ ++ +
Sbjct: 1457 EWKQKYEESQSELESSQKEARSL-------STELFKLKNAYE---ESLEHLETFKRENKN 1506
Query: 332 HKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSD 391
+EE+ + + +LGE K + +LE+ +L++E +L ++S
Sbjct: 1507 LQEEISDLTE-QLGEGGKNV-------HELEKVRKQLEVE-------------KLELQSA 1545
Query: 392 LETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIE 451
LE LE E+ ++ + F Q+ E+ER E +
Sbjct: 1546 LEEAEASLEHEEGKILRAQLEF----NQIKAEIERKLAEK-------------------D 1582
Query: 452 EERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRM 511
EE + K+ +R ++ S R ++ + R +K +++++ + RM
Sbjct: 1583 EEMEQAKRNHQR---VVDSLQTSLDAETRSRNEVLRVKKK--MEGDLNEMEIQLSHANRM 1637
Query: 512 LERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEK 571
+K ++ +QS +K + D ++ +E ++++E+
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN-----------------IAIVERRN 1680
Query: 572 ELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQ----------LE 621
L + AE E LR +E E + EL +T E + ++ Q +E
Sbjct: 1681 NL-------LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKME 1733
Query: 622 SEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVD 681
S+ +L+S+V + + E K K + +A + ++ L + + +++++
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1793
Query: 682 DYQHRL-SIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQ 740
D QHRL ++ L+ + Q++ LE ++ EL ++ ++ + K + ++ L
Sbjct: 1794 DLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELT 1853
Query: 741 ETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLD 800
+E + + LQ+ + + V K E E N E++ + D
Sbjct: 1854 YQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1913
Query: 801 AAHKELDEV-GRSREIAFKE 819
A +++++ +SR+I K+
Sbjct: 1914 IAESQVNKLRAKSRDIGAKQ 1933
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 142 bits (358), Expect = 2e-33
Identities = 201/930 (21%), Positives = 405/930 (43%), Gaps = 112/930 (12%)
Query: 205 RIQELQQEVHQLQEKLAMMES--GVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+I+ L + +E M E +D + E + +E+E V L ++ L +++
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
++ + + D L +A LE +I+E+ E E L+ K KL E +E+
Sbjct: 896 SEN----LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 951
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K E+ L+ET+AKL E Q+ ++
Sbjct: 952 KKDIDDLEL----TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA 1007
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER--MRLEHGIKRRDRSP 440
D+L + D +++ + + ++ + +ES E++L +++ER +LE +K S
Sbjct: 1008 LDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI 1067
Query: 441 SRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQ 500
L+ + ++E KK+ E C ++ ++ Q
Sbjct: 1068 LDLENDKQQLDER--LKKKDFE---------YCQLQSKVEDEQTLGL------------Q 1104
Query: 501 ITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAP 560
++ ELQ +E E E+I++ + A+ +K Y EELS +E+ T+
Sbjct: 1105 FQKKIKELQARIEELE---EEIEAE-RATRAKTEKQRSDYARELEELSERLEEAGGVTST 1160
Query: 561 HNIVSLMEKEKELALSDLRRIMAEKEALREKL------EHIEEVSLFGKSELEKTIEHLT 614
+ K++E LRR + E E + +H + V +EL + I++L
Sbjct: 1161 Q---IELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSV-----AELGEQIDNLQ 1212
Query: 615 CVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNE 674
V +LE EK E K ++ + ++ES+ +K K +K D +++ R NE
Sbjct: 1213 RVKQKLEKEKSEFKLEIDDLSSSMESV-SKSKANLEKICRTLED------QLSEARGKNE 1265
Query: 675 QLQRSVDD---YQHRLSIKRGEL-------ESAQAQI----KILEEKIDELNLKMTSQDE 720
++QRS+ + + RL + GEL ES +Q+ + ++ +EL ++ +++
Sbjct: 1266 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 1325
Query: 721 EAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQ 780
+ + + + D L+E +E+ E A LQ L+ VAQ + ++ E+ Q
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR---TKYETDAIQ 1382
Query: 781 LKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLE 840
E L ++ L ++L + ++++ V K +RLQ ++ + + + +
Sbjct: 1383 RTEELEEAKKK---LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN-S 1438
Query: 841 LEAAVQEKEEMKSRV-HKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQ 899
L AA+ +K+ +V ++ T+ ++ + A KE++ L L N E +
Sbjct: 1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE-------E 1491
Query: 900 AEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEE 959
A + +V+ E +++ E L E++ K I E + E + + + A+ E
Sbjct: 1492 ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551
Query: 960 LRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENV------- 1012
L H+E + + +L+ ++ + + KD +QL ++R V +++
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR---NYQRTVETMQSALDAEVRS 1608
Query: 1013 KSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE---KDTEIQL--------- 1060
++E+ LKK++ + + ++ ++ A + E HL S + KDT++ L
Sbjct: 1609 RNEAIRLKKKMEGDLNEIE-IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED 1667
Query: 1061 LKEKLTLSESKLTSQSRENTMLRAKVAQLQ 1090
LKE+L + E + E LRA + Q +
Sbjct: 1668 LKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Score = 133 bits (335), Expect = 8e-31
Identities = 225/1158 (19%), Positives = 471/1158 (40%), Gaps = 182/1158 (15%)
Query: 43 TTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLE-------LMKLREH 95
T + + K K + E A + + + + L +E N+L L+ L+ E
Sbjct: 846 TEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEER 905
Query: 96 SDQHVK---ELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQ------ 146
DQ +K +L+ +K+ D + +N + K + LE E + I L+
Sbjct: 906 CDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 965
Query: 147 EKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRI 206
EK HA K +++ + +DE + + + + DL Q ++++
Sbjct: 966 EKEKHATEN----KVKNLT--EELSGLDETIAKLTREKKALQEAHQQALDDL-QAEEDKV 1018
Query: 207 QELQQEVHQLQEKLAMMESGVRDYSK---QIELREREIER-LSVALDG--GRSPDVLSLE 260
L + +L++++ +ES + K +E +R++E L +A + D L+
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 261 SRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELM----ETKETVTSEVVNLSNKNEKLC 316
R K + L +V+ Q +K+I+EL E +E + +E + ++
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS 1138
Query: 317 QELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQ 376
E+++L+++LE E ++ KK L +DLEE A LQ E +
Sbjct: 1139 DYARELEELSERLE----EAGGVTSTQIELNKKREAEFLKLRRDLEE--ATLQHEAMVAA 1192
Query: 377 KEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRR 436
K+ ++L + L++ KQ+L K+ F + L+ +E +
Sbjct: 1193 LRKKHADSV----AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV--------- 1239
Query: 437 DRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRT-PEKGDYN 495
+S + L+ + +E++ + + E +Q + + S E + R EK
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Query: 496 SEIHQ----ITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALR 551
S++ + T++ +EL+R LE K + ++ + D L Y E QE + L+
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 552 KESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIE 611
+ ++ + + K + A+ + K+ L ++L+ EE +E
Sbjct: 1360 RALSKANS--EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEE-----------QVE 1406
Query: 612 HLTCVNHQLESEKYELKSKV---LIMKETIESLENKLKVQAQKFSHVAGD--------SS 660
+ LE K L+ +V ++ E SL L + + F V + +
Sbjct: 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466
Query: 661 HQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDE 720
+ + R ++ +L + + Y+ L +LE+ + + K LE++I +L ++ +
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALD----QLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 721 EAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQ 780
H ++K+ I+ EK +Q ++E + L ++E + ++++ +++ +S +++
Sbjct: 1523 TIHELEKSRKQIELEKADIQLALEEA-------EAALEHEEAKILRIQLELTQVKSEIDR 1575
Query: 781 LKETLVNRDREINSLRRQ----LDAAHKELDEVGRSREIAFKENRRLQDDL--------- 827
+ +D EI L+R ++ LD RSR A + ++++ DL
Sbjct: 1576 ---KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632
Query: 828 ------------ATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKE 875
++ + ++ L L+ A++ +E++K + + V R +L+ A+ +E
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ----LAIVERRANLLQAEVEE 1688
Query: 876 ---------------NQDLLD---RFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTE 917
Q+LLD R Q+LH + + E + ++ E+ +
Sbjct: 1689 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD 1748
Query: 918 RRHLRERVELLEKE---IQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDL 974
R+ E+ + + + E + + + M K + + ++L+H+ DE
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE-------- 1800
Query: 975 SSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDL---------LKKQLSN 1025
+L +K K I + + LEFE + +N +S L L Q
Sbjct: 1801 --AEQLALK-GGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEE 1857
Query: 1026 ERHTVKNLESLL-------------ATNRDKEFHSHLTSHEK-DTEIQLLKEKLTLSES- 1070
+R V L+ L+ A D++ ++HLT K E++ +E+ ++ES
Sbjct: 1858 DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQ 1917
Query: 1071 --KLTSQSRENTMLRAKV 1086
KL +++R+ T R V
Sbjct: 1918 VNKLRAKTRDFTSSRMVV 1935
Score = 132 bits (332), Expect = 2e-30
Identities = 215/1126 (19%), Positives = 455/1126 (40%), Gaps = 133/1126 (11%)
Query: 22 RQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRE 81
R+ L + + LV++ +DL ++ ++ L A + + F LE E + +
Sbjct: 871 RKELEEKLVTLVQEK-NDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAED 929
Query: 82 NNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNER 141
E+ EL + + ELK ++ DL+ L +EKE A +
Sbjct: 930 EEEINAELTAKKRKLEDECSELK-------KDIDDLEL-------TLAKVEKEKHATENK 975
Query: 142 IQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQV 201
++ L E + G + R++ + E D LQ
Sbjct: 976 VKNLTE-------ELSGLDETIAKLTREKKALQEA---------------HQQALDDLQA 1013
Query: 202 ADNRIQELQQEVHQLQEKLAMMESGVRDYSK---QIELREREIE-RLSVALDG--GRSPD 255
++++ L + +L++++ +ES + K +E +R++E L +A + D
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Query: 256 VLSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELM----ETKETVTSEVVNLSNK 311
L+ R K + L +V+ Q +K+I+EL E +E + +E +
Sbjct: 1074 KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKT 1133
Query: 312 NEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLE 371
++ E+++L+++L EE ++ KK L +DLEE A LQ E
Sbjct: 1134 EKQRSDYARELEELSERL----EEAGGVTSTQIELNKKREAEFLKLRRDLEE--ATLQHE 1187
Query: 372 LNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEH 431
+ K+ ++L + L++ KQ+L K+ F + L+ +E +
Sbjct: 1188 AMVAALRKKHADS----VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV---- 1239
Query: 432 GIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFR-TPE 490
+S + L+ + +E++ + + E +Q + + S E + R E
Sbjct: 1240 -----SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Query: 491 KGDYNSEIHQ----ITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEE 546
K S++ + T++ +EL+R LE K + ++ + D L Y E QE
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 547 LSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSEL 606
+ L++ ++ A + K + A+ + K+ L ++L+ EE
Sbjct: 1355 KAELQRALSK--ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEE--------- 1403
Query: 607 EKTIEHLTCVNHQLESEKYELKSKV---LIMKETIESLENKLKVQAQKFSHVAGD----- 658
+E + LE K L+ +V ++ E SL L + + F V +
Sbjct: 1404 --QVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Query: 659 ---SSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKM 715
+ + + R ++ +L + + Y+ L +LE+ + + K LE++I +L ++
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALD----QLETVKRENKNLEQEIADLTEQI 1517
Query: 716 TSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECE 775
+ H ++K+ I+ EK +Q ++E + L ++E + ++++ +++ +
Sbjct: 1518 AENGKTIHELEKSRKQIELEKADIQLALEE-------AEAALEHEEAKILRIQLELTQVK 1570
Query: 776 SSVNQLKETLVNRDREINSLRRQ----LDAAHKELDEVGRSREIAFKENRRLQDDLATMA 831
S +++ + +D EI L+R ++ LD RSR A + ++++ DL
Sbjct: 1571 SEIDR---KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL---- 1623
Query: 832 RENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAE 891
EI ++L A ++ E + ++ + + + +DL ++ ++ RA
Sbjct: 1624 ---NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAN 1680
Query: 892 DWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAK 951
+ + + + E ERV+LL + I+ E+ + +
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Query: 952 AMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN 1011
+ + R+ E++ + D + + E +L +D + L E+ V +L++
Sbjct: 1741 EVEDASRDARNAEEKAKKAITDAAMMAE---ELKKEQD-TSAHLERMKKNLEQTVKDLQH 1796
Query: 1012 VKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESK 1071
E++ L L + ++ LE+ + R+ EF +K+TE K +
Sbjct: 1797 RLDEAEQL--ALKGGKKQIQKLETRI---RELEFELE-GEQKKNTESVKGLRKYERRVKE 1850
Query: 1072 LTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRRH 1117
LT QS E+ R V +LQ D L+ ++ + + + E A ++ H
Sbjct: 1851 LTYQSEED---RKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893
Score = 80.5 bits (197), Expect = 8e-15
Identities = 110/521 (21%), Positives = 221/521 (42%), Gaps = 77/521 (14%)
Query: 603 KSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQ 662
K E +KT + L + E+++ EL+ K++ T+ +N L++Q Q S D+ +
Sbjct: 854 KEEFQKTKDELA----KSEAKRKELEEKLV----TLVQEKNDLQLQVQAESENLLDAEER 905
Query: 663 KTEVNSLRI-----VNEQLQRSVDDYQ--HRLSIKRGELESAQAQIKILEEKIDELNLKM 715
++ + + E +R+ D+ + L+ K+ +LE +++K + ID+L L +
Sbjct: 906 CDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK---KDIDDLELTL 962
Query: 716 TSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECE 775
++E H + + + +E L ET+ + T + LQE A Q + E
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE-------AHQQALDDLQAEE 1015
Query: 776 SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQ 835
VN L +T ++++ L L+ K ++ R++ R+L+ DL Q
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK-------RKLEGDLKLA----Q 1064
Query: 836 EISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEV 895
E L+LE +K+++ R+ K E + +S + ++ + + L R E+ E
Sbjct: 1065 ESILDLE---NDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEE 1121
Query: 896 KAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSR 955
+ + + E L ER+E I + E++ + + +
Sbjct: 1122 EIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLE- 1180
Query: 956 LEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSE 1015
E L+H+ A S+ EL ++D+ + + Q+L + EF+ +E++++ S
Sbjct: 1181 -EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK-QKLEKEKSEFK---LEIDDLSSS 1235
Query: 1016 SDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQ 1075
+ + K +N + LE L+ R K E++ S S+LT+Q
Sbjct: 1236 MESVSKSKANLEKICRTLEDQLSEARGKN------------------EEIQRSLSELTTQ 1277
Query: 1076 SRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRR 1116
++LQT+ L RQ+ E+E + ++ R
Sbjct: 1278 K----------SRLQTEAGELSRQLE----EKESIVSQLSR 1304
Score = 64.7 bits (156), Expect = 5e-10
Identities = 68/323 (21%), Positives = 141/323 (43%), Gaps = 38/323 (11%)
Query: 818 KENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQ 877
+E ++ +D+LA + +E+ +L VQEK +++ +V + E+L+ A+E+ +Q
Sbjct: 855 EEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ------AESENLLDAEERCDQ 908
Query: 878 DLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHIN 937
+ +FQ L + ++ +A E ++ + + ++ E L++ ++ LE + +
Sbjct: 909 LIKAKFQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 967
Query: 938 AHHAYESQISSMAKAMSRLEEELRHQEDEKATV-------LNDLSSLRELCIKLDSGKDI 990
HA E+++ ++ + +S L+E + EK + L+DL + + L+ K
Sbjct: 968 EKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK 1027
Query: 991 MTQQLNSKNLEFE-----RVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEF 1045
+ QQ+ E RV +E K E DL Q ES+L DK+
Sbjct: 1028 LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-----------ESILDLENDKQ- 1075
Query: 1046 HSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERY 1105
+ D ++ + +SK+ + + K+ +LQ + L+ +I ER
Sbjct: 1076 -------QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 1106 ERERAIQEMRRHGLATPPLSSTL 1128
R + ++ + LS L
Sbjct: 1129 TRAKTEKQRSDYARELEELSERL 1151
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 142 bits (357), Expect = 2e-33
Identities = 232/1119 (20%), Positives = 482/1119 (43%), Gaps = 166/1119 (14%)
Query: 5 VERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKA---EKES 61
+E K + + K + L + + L E+ L+ L ++K+ V E+E
Sbjct: 876 LEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQL-EAKIKEVTERAEEEEE 934
Query: 62 ANFDFVLEPYKLEN--ARLSRENNELYLELMKLREH---SDQHVKELKTSL----KKCAR 112
N + + KLE+ + L ++ ++L L L K+ + ++ VK L + + A+
Sbjct: 935 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 994
Query: 113 ETADLKFLNNQYAHKLKLLEKE-------SKAKNERIQQL--------QEKNLHAVVQTP 157
+ + K L + L L+ E +KAK + QQ+ QEK L ++
Sbjct: 995 LSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERA 1054
Query: 158 GGK---------KRSIAFRRQRMQIDEPVPPSE--VSSYPVPQPDDPYIADLLQVADNRI 206
K + ++ + Q+DE + E +S+ D+ + LQ +I
Sbjct: 1055 KRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ---KKI 1111
Query: 207 QELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTN 266
+ELQ + +L E++ + KQ RE+E +S L+ E+ T+
Sbjct: 1112 KELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLE----------EAGGATS 1161
Query: 267 EKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLA 326
++ + + +F Q+ +DLE+ ++ + V + ++ +L +++ + ++
Sbjct: 1162 AQVELNKKREAEF-QKLRRDLEEAT---LQHEAMVAALRKKHADSMAELGEQIDNLQRVK 1217
Query: 327 QQLERHKEEV-LETAD-KELGEAKKEIKRKLSEM-QDLEETMAKLQLELNLCQKEKERLS 383
Q+LE+ K E+ +ET D EA + K L +M + LE+ +++L+ + ++E++RL
Sbjct: 1218 QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK----EEEQQRLI 1273
Query: 384 DELLV-KSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMR--LEHGIKRRDRSP 440
++L ++ L+T + ++ V + +++ T ++E ++ LE K ++
Sbjct: 1274 NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALA 1333
Query: 441 SRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAR-----EKSSIFRTPEKGDYN 495
L + + R+ Y++E E + + S + S A+ E +I RT E +
Sbjct: 1334 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1393
Query: 496 SEIHQITRERDE-----------LQRMLERFEKYMEDIQSNVKLLTA--------ERDKL 536
++ Q +E +E L++ +R + +ED+ +V+ A +R+
Sbjct: 1394 KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFD 1453
Query: 537 SVL------YNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALRE 590
VL Y E Q EL A +KES + V + +E L LRR E + L++
Sbjct: 1454 KVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRR---ENKNLQQ 1510
Query: 591 KLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQ 650
++ + E G K I L + Q+E EK E+++ ++E SLE
Sbjct: 1511 EISDLTEQIAEGG----KQIHELEKIKKQVEQEKCEIQAA---LEEAEASLE-------- 1555
Query: 651 KFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQ-IKILEEKID 709
H++ ++ +++ Q++ VD +++ K E++ + +++E
Sbjct: 1556 ----------HEEGKILRIQLELNQVKSEVD---RKIAEKDEEIDQLKRNHTRVVETMQS 1602
Query: 710 ELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKI 769
L+ ++ S+++ V KK G +++ ++ ++ A N N + + + ++
Sbjct: 1603 TLDAEIRSRNDALRVKKKMEGDLNE----MEIQLNHANRLAAESLRNYRNTQGILKETQL 1658
Query: 770 MISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKE---------- 819
+ + LKE L +R N L+ +++ L++ RSR+IA +E
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Query: 820 ----NRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKE 875
N L + + + ++ E+E +QE + + K IT+ ++MA + K+
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA----AMMAEELKK 1774
Query: 876 NQDL---LDRFQM-LHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKE 931
QD L+R + L +D + + +AE +L L + + L RV LE E
Sbjct: 1775 EQDTSAHLERMKKNLEQTVKDLQHRLDEAE------QLALKGGKKQIQKLEARVRELEGE 1828
Query: 932 IQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGK--- 988
++ N + + K R++E E+++ VL + +L K+ S K
Sbjct: 1829 VE---NEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQA 1885
Query: 989 DIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNER 1027
+ +Q N+ +F ++ ELE + +D+ + Q++ R
Sbjct: 1886 EEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLR 1924
Score = 137 bits (346), Expect = 4e-32
Identities = 190/930 (20%), Positives = 374/930 (40%), Gaps = 106/930 (11%)
Query: 205 RIQELQQEVHQLQEKLAMMES--GVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+I+ L + +E M E +D + E + +E+E V L ++ L ++S
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
+ +A + + L + LE +I+E+ E E L+ K KL E +E+
Sbjct: 898 ADS----LADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K EM L+ET+AKL E Q+ ++
Sbjct: 954 KKDIDDLEL----TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQT 1009
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVER--MRLEHGIKRRDRSP 440
D+L + D ++ + + + ++ +E E++L +++ER +LE +K S
Sbjct: 1010 LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST 1069
Query: 441 SRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQ 500
++ + ++E+ + KKE E + ++I S+I
Sbjct: 1070 MDMENDKQQLDEKLE--KKEFE-ISNLI---------------------------SKIED 1099
Query: 501 ITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAP 560
+LQ+ ++ + +E++ ++ A R K ++ EL + + +
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1159
Query: 561 HNIVSLMEKEKELALSDLRRIMAEKEALREKL-EHIEEVSLFGKSELEKTIEHLTCVNHQ 619
+ + K++E LRR + E E + + + +EL + I++L V +
Sbjct: 1160 TSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQK 1219
Query: 620 LESEKYELKSKVLIMKETIE-------SLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIV 672
LE EK ELK + + E +LE + + S + Q+ +N L
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279
Query: 673 NEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVI 732
+LQ +Y +L K + + ++I+EL ++ + + + + +
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS 1339
Query: 733 DKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREI 792
+ D L+E +E+ E A LQ L+ VAQ + + + + R E+
Sbjct: 1340 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR----------TKYETDAIQRTEEL 1389
Query: 793 NSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQE-ISLELEAAVQEKEEM 851
+++L +RLQ+ A E+ E ++ + + + K+ +
Sbjct: 1390 EEAKKKL--------------------AQRLQE-----AEEHVEAVNAKCASLEKTKQRL 1424
Query: 852 KSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLEL 911
++ V + +V R + AA +K+ ++ + E+ + + ++ ES S+ EL
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 912 LSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVL 971
+ +++E L +E + QI+ K + LE+ + E EK +
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQ 1544
Query: 972 NDLSSLRELCIKLDSGKDIMTQ-QLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTV 1030
L E ++ + GK + Q +LN E +R + E + E D LK+ N V
Sbjct: 1545 AALEE-AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKR---NHTRVV 1597
Query: 1031 KNLESLL-----ATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAK 1085
+ ++S L + N + + EIQL +ES ++ NT K
Sbjct: 1598 ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES---LRNYRNTQGILK 1654
Query: 1086 VAQLQTDYDALKRQISTERYERERAIQEMR 1115
QL D DAL+ Q E + + AI E R
Sbjct: 1655 ETQLHLD-DALRGQ---EDLKEQLAIVERR 1680
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 141 bits (355), Expect = 4e-33
Identities = 207/1070 (19%), Positives = 454/1070 (42%), Gaps = 120/1070 (11%)
Query: 105 TSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSI 164
T +K + T + L + LK+ EK++K + E +++++ K+ + ++++I
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGE-LEEMERKHQQLL------EEKNI 891
Query: 165 AFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAMME 224
+ + + + E+ + + + + ++L ++R++E ++ LQ + M+
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQE--LEEILHDLESRVEEEEERNQILQNEKKKMQ 949
Query: 225 SGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQAN 284
+ ++D +Q++ E ++L + + ++ E++ K E+ I L Q +
Sbjct: 950 AHIQDLEEQLDEEEGARQKLQL--------EKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 285 KDLEKRIREL---METKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETAD 341
K +E RI E + +E + + NK E + +L E R K+E E
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEE---------RLKKE--EKTR 1050
Query: 342 KELGEAKKEIKRKLSEMQD-LEETMAKL-QLELNLCQKEKE------RLSDELLVKSDLE 393
+EL +AK+++ + +++QD + E A++ +L+L L +KE+E R DE L K++
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 394 TVVHQLEQEKQRLSKKVESFAVT-------ERQLTLEVERMRLE---------HGIKRRD 437
VV +L+ + L + ES + +R L+ E+E ++ E + R
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 438 RSPSRLDTFLKGIEEERDYYKKELE--RLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYN 495
+ + K +EEE ++ +++ R +H S ++ K
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 496 SEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKEST 555
++ ++ E LQ++ E + + + V+ L A+ + L E E+ S L+ E
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 556 QTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTC 615
N+ +L+E+ ++ + + + + L++ E ++E + K L I
Sbjct: 1291 ------NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR-QKLNLSSRIR---- 1339
Query: 616 VNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQ 675
QLE EK L+ + +E ++LE ++ + + + SL ++
Sbjct: 1340 ---QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 676 LQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKE 735
L + + RL K + + L++++D+L + + Q + A ++K K+
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEK------KQ 1450
Query: 736 KDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRD---REI 792
K F Q +EK+ +E +++A A+ + ++ S L+E L ++ R+
Sbjct: 1451 KKFDQLLAEEKSISARYAEE----RDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 793 NSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMK 852
LR ++ D+VG++ K R L+ + M + +E+ EL+A E+ K
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT----EDAK 1562
Query: 853 SRVHKYITEV-SRWESLMAAKEKENQD----LLDRFQMLHNRAEDWEVKAHQAEGESSSV 907
R+ + + +++E + ++++N++ L+ + + L ED + A +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKM 1622
Query: 908 RLELLSIDTE--------------RRHLRERVELLEKEIQEHINAHHAY-------ESQI 946
++L ++ + R L+ +++ ++E++E + E ++
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 947 SSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVV 1006
S+ + +L+EEL E + + L + SGK + + ++
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 1007 VELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEKLT 1066
ELE +S +LL + V L + LA R S + + + + LK KL
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 1067 LSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMRR 1116
E + S+ +A ++ L+ L+ Q+ E ER A + +RR
Sbjct: 1803 ELEGAVKSK------FKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Score = 135 bits (340), Expect = 2e-31
Identities = 233/1117 (20%), Positives = 466/1117 (41%), Gaps = 144/1117 (12%)
Query: 3 TAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKESA 62
T VE + + ++ QL + + E L +LF++ E +R ++L+A K E E
Sbjct: 869 TKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE----AEEMR-ARLAAKKQELEEI 923
Query: 63 NFDFV--LEPYKLENARLSRENNELYLELMKLREHSDQHVKE----------LKTSLKKC 110
D +E + N L E ++ + L E D+ + +KK
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983
Query: 111 ARETADLKFLNNQYAHKLKLLE------------KESKAKN-ERIQQLQE---KNLHAVV 154
E L+ N+++ + KL+E +E KAKN +I+ QE +L +
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 155 QTPGGKKRSIAFRRQRM---------QIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNR 205
+ ++ + ++++ QI E + + + ++ L + D
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103
Query: 206 ---------IQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDV 256
++ELQ ++ +LQE ++ KQ E+E L L+
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163
Query: 257 LSLESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLC 316
E R K E+ +A L L++ K+ E +I+++ + T E+L
Sbjct: 1164 AQQELRTK-REQEVAELK---KALEEETKNHEAQIQDMRQRHATAL----------EELS 1209
Query: 317 QELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQ 376
++L + + LE++K+ LET +KEL K +++ +E + + + EL+
Sbjct: 1210 EQLEQAKRFKANLEKNKQG-LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 377 KEKERLSDELLVKS-----DLETVVHQLEQEKQRLSKKVESFAVTERQLT----LEVERM 427
E +RL EL K+ +L+ V LE+ +++ K + A E QL L E
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 428 RLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFR 487
R + + R R L+ +EE + +K LE+ +Q + T +
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE 1388
Query: 488 TPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEEL 547
+ E+ ++ ++ + L + LE + ++ L E D L+V + ++
Sbjct: 1389 SLEEAK-----KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA 1443
Query: 548 SALRKESTQ----TTAPHNIVSLMEKEKELALSDLR----RIMAEKEALREKLEHIEEVS 599
S L K+ + +I + +E++ A ++ R + ++ AL E LE EE
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503
Query: 600 LFGKSELEKTIEHLTCVN-------HQLESEKYELKSKVLIMKETIESLENKLKVQAQKF 652
K +L +E L H+LE K L+ +V M+ +E LE++L+
Sbjct: 1504 RQNK-QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ------ 1556
Query: 653 SHVAGDSSHQKTEVNSLRIVNEQLQRSV------DDYQHRLSIKR-----GELESAQAQ- 700
A + + + EVN ++ + Q +R + ++ + RL IK+ ELE + Q
Sbjct: 1557 ---ATEDAKLRLEVN-MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 701 -IKILEEKIDELNLK-MTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLA 758
+ + +K E++LK + +Q E A+ K VI + + + D + E L+E A
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAAN--KARDEVIKQLRKLQAQMKDYQRE----LEEARA 1666
Query: 759 NKEKAVAQMKIM---ISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREI 815
++++ AQ K + E+ + QL+E L + +R ++ D E+ +
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 816 AFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKE 875
E RRL+ +A ++ ELE E + R K +V + +AA+
Sbjct: 1727 LLDEKRRLEARIA-------QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 876 NQDLLDRFQMLHNRAEDWEVKAHQAEGE-SSSVRLELLSIDTERRHLRERVELLEKEIQE 934
Q + Q L + ++ + K + EG S + + +++ + L E+ LE+E +E
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQ---LEQEAKE 1836
Query: 935 HINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQ 994
A+ + + ++E+E RH + K + + +++L +L+ ++ T +
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT-R 1895
Query: 995 LNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVK 1031
N+ + +R EL++ ++ L +++S ++ ++
Sbjct: 1896 ANASRRKLQR---ELDDATEANEGLSREVSTLKNRLR 1929
Score = 120 bits (301), Expect = 7e-27
Identities = 176/949 (18%), Positives = 388/949 (40%), Gaps = 78/949 (8%)
Query: 34 EKLFSDLVHTTESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR 93
E + SDL E L++ + + + EK D + + A L + +EL L+L K
Sbjct: 1033 EVMISDL---EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089
Query: 94 EH-------SDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQ 146
E D +LK A + L + + K K K + ++L+
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE 1149
Query: 147 --EKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADN 204
+ L + T ++ R Q + + E ++ + I D+ Q
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH------EAQIQDMRQRHAT 1203
Query: 205 RIQELQQEVHQLQEKLAMMES---GVRDYSKQIELREREIERLSVALDGGRSP---DVLS 258
++EL +++ Q + A +E G+ +K++ + ++++ + R V
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 259 LESRNKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQE 318
L ++ ++L +V+ ++A+K L+ + + E + + + L +
Sbjct: 1264 LHAKVSEGDRL------RVELAEKASK-LQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 319 LTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKE 378
L + +L Q+ R K L + ++L +E K L E Q+ EE A+ LE + +
Sbjct: 1317 LQDTQELLQEETRQKLN-LSSRIRQL----EEEKNSLQEQQE-EEEEARKNLEKQVLALQ 1370
Query: 379 KERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDR 438
+ + V DL T+ LE+ K++L K E+ + + L +++ K ++R
Sbjct: 1371 SQLADTKKKVDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYDKLE-----KTKNR 1424
Query: 439 SPSRLDTFLKGIEEER----DYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDY 494
LD ++ +R + KK+ + Q + + +S S Y+ + EK
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK--- 1481
Query: 495 NSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKES 554
++ + R +E E FE+ + ++++++ L + +D + +E ++ AL ++
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Query: 555 TQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKT---IE 611
+ L E E EL ++ ++ E K + ++ + EK I+
Sbjct: 1542 EEMRT-----QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596
Query: 612 HLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRI 671
+ + +LE E+ + ++ + K+ +E L+ Q + A + + + + LR
Sbjct: 1597 QVRELEAELEDERKQ-RALAVASKKKMEIDLKDLEAQIE-----AANKARDEV-IKQLR- 1648
Query: 672 VNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGV 731
+LQ + DYQ L R + AQ K E+K+ L ++ EE ++
Sbjct: 1649 ---KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 732 IDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDRE 791
++E+D L + + + L + E +AQ++ + E +S++ L + +
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 792 INSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDL-----ATMARENQEISLELEAAVQ 846
+++L +L A + +R+ ++N+ L+ L A ++ IS LEA +
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS-ALEAKIG 1824
Query: 847 EKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSS 906
+ EE + K E + L+ EK+ +++ + + A+ ++ + +A
Sbjct: 1825 QLEEQLEQEAK---ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQ 1881
Query: 907 VRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSR 955
++ +L + E L++E+ + A+ ++S++ + R
Sbjct: 1882 LKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 140 bits (354), Expect = 5e-33
Identities = 189/942 (20%), Positives = 394/942 (41%), Gaps = 106/942 (11%)
Query: 205 RIQELQQEVHQLQEKLAMMES--GVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+I+ L + +E M E ++D + E + +E+E V L ++ L+ +
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKN----DLQLQ 896
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
+ + +A + D L + LE +I+E+ E E L+ K KL E +E+
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K EM L+ET+AKL E Q+ ++
Sbjct: 957 KKDIDDLEL----TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKV---ESFAVTERQLTLEVER--MRLEHGIKRRD 437
D+L + D V+ L + K +L ++V E E++L +++ER +LE +K
Sbjct: 1013 LDDLQAEED---KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 438 RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSE 497
S + IE E+ ++L++ + E + S+
Sbjct: 1070 ES-------IMDIENEKQQLDEKLKKKEF-----------------------EISNLQSK 1099
Query: 498 IHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQT 557
I +LQ+ ++ + +E+++ ++ A R K ++ EL + + +
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1159
Query: 558 TAPHNIVSLMEKEKELALSDLRRIMAEKEALRE------KLEHIEEVSLFGKSELEKTIE 611
+ M K++E +RR + E E + +H + V +EL + I+
Sbjct: 1160 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV-----AELGEQID 1214
Query: 612 HLTCVNHQLESEKYELKSKVLIMKETIE-------SLENKLKVQAQKFSHVAGDSSHQKT 664
+L V +LE EK E+K ++ + +E +LE + + S + Q+
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQR 1274
Query: 665 EVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHV 724
+N L +LQ ++ +L K + + ++I+EL ++ + + +
Sbjct: 1275 LINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA 1334
Query: 725 MKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKET 784
+ + + D L+E +E+ E A LQ L+ VAQ + ++ E+ Q E
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR---TKYETDAIQRTEE 1391
Query: 785 LVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAA 844
L ++ L ++L AA + ++ V K +RLQ+++ + + + + A
Sbjct: 1392 LEEAKKK---LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 845 VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904
+++ + ++ + + + A +KE + L + N E+ + + E+
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 905 SSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQE 964
+++ E+ + + +R+ LEK I++ + E + + A+ E L H+E
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEK-IKKQV------EQEKCELQAALEEAEASLEHEE 1561
Query: 965 DEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN-----VKSESDL- 1018
+ + +L+ ++ + + KD QL ++ R+V +++ ++S +D
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI---RIVESMQSTLDAEIRSRNDAI 1618
Query: 1019 -LKKQLS---NERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQL---LKEKLTLSESK 1071
LKK++ NE N + +A + + + KDT+I L L+ + L E +
Sbjct: 1619 RLKKKMEGDLNEMEIQLNHANRMAAEALRNYR-NTQGILKDTQIHLDDALRSQEDLKE-Q 1676
Query: 1072 LTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQE 1113
L R +L+A++ +L+ + E+ ER R I E
Sbjct: 1677 LAMVERRANLLQAEIEELRA---------TLEQTERSRKIAE 1709
Score = 135 bits (339), Expect = 3e-31
Identities = 230/1127 (20%), Positives = 463/1127 (41%), Gaps = 182/1127 (16%)
Query: 5 VERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKA---EKES 61
+E K + + K + L + E L E+ L+ T L ++K+ V ++E
Sbjct: 879 LEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQL-EAKIKEVTERAEDEEE 937
Query: 62 ANFDFVLEPYKLEN--ARLSRENNELYLELMKLREH---SDQHVKELKTSL----KKCAR 112
N + + KLE+ + L ++ ++L L L K+ + ++ VK L + + A+
Sbjct: 938 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 997
Query: 113 ETADLKFLNNQYAHKLKLLEKE-------SKAKNERIQQL--------QEKNLHAVVQTP 157
T + K L + L L+ E +KAK + QQ+ QEK L ++
Sbjct: 998 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA 1057
Query: 158 GGKKRS---------IAFRRQRMQIDEPVPPSE--VSSYPVPQPDDPYIADLLQVADNRI 206
K + ++ Q+DE + E +S+ D+ + LQ +I
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ---KKI 1114
Query: 207 QELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALD---GGRSPDVLSLESRN 263
+ELQ + +L+E++ + KQ RE+E +S L+ G S + + R
Sbjct: 1115 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174
Query: 264 KTNEKL-------------------------IAHLNIQVDFLQQANKDLEKRIRELMETK 298
+K+ +A L Q+D LQ+ + LEK E+
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI 1234
Query: 299 ETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEM 358
+ + S V +S L E++ T + +L E K + + + +
Sbjct: 1235 DDLASNVETVSKAKGNL------------------EKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 359 QDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTER 418
DL +LQ E E R DE E +V QL + KQ ++++E +R
Sbjct: 1277 NDLTAQRGRLQTE----SGEFSRQLDE------KEALVSQLSRGKQAFTQQIEEL---KR 1323
Query: 419 QLTLEVE-RMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSY 477
QL E++ + L H ++ S D + EEE++ K EL+R
Sbjct: 1324 QLEEEIKAKNALAHALQ---SSRHDCDLLREQYEEEQE-SKAELQR-----------ALS 1368
Query: 478 SAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLS 537
A + + +RT + D ++ + +L + L+ E+++E + N K + E+ K
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV--NAKCASLEKTK-- 1424
Query: 538 VLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRR----IMAEKEALREKLE 593
Q E+ L + +T A + ++ + L++ ++ AE EA +++
Sbjct: 1425 ---QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEAR 1481
Query: 594 HIEEVSLFGKSELEKTIEHLTCV---NHQLESEKYELKSKVLIMKETIESLENKLKVQAQ 650
+ K+ E++++ L + N L+ E +L ++ + I LE K+K Q +
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVE 1540
Query: 651 K--------FSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQA-QI 701
+ H++ ++ +++ Q++ VD +++ K E++ + I
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEIDQLKRNHI 1597
Query: 702 KILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKE 761
+I+E L+ ++ S+++ + KK G +++ ++ ++ A N N +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE----MEIQLNHANRMAAEALRNYRNTQ 1653
Query: 762 KAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKE-- 819
+ +I + + S LKE L +R N L+ +++ L++ RSR+IA +E
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL 1713
Query: 820 ------------NRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWES 867
N L + + + ++ E+E +QE + + K IT+ +
Sbjct: 1714 DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA----A 1769
Query: 868 LMAAKEKENQDL---LDRFQM-LHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRE 923
+MA + K+ QD L+R + + +D +++ +AE +L L + + L
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE------QLALKGGKKQIQKLEA 1823
Query: 924 RVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIK 983
RV LE E++ + + + K R++E E+++ +L + +L K
Sbjct: 1824 RVRELEGEVESEQKRN---AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAK 1880
Query: 984 LDSGK---DIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNER 1027
+ S K + +Q N+ +F ++ ELE + +D+ + Q++ R
Sbjct: 1881 VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 140 bits (354), Expect = 5e-33
Identities = 189/942 (20%), Positives = 394/942 (41%), Gaps = 106/942 (11%)
Query: 205 RIQELQQEVHQLQEKLAMMES--GVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+I+ L + +E M E ++D + E + +E+E V L ++ L+ +
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKN----DLQLQ 896
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
+ + +A + D L + LE +I+E+ E E L+ K KL E +E+
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K EM L+ET+AKL E Q+ ++
Sbjct: 957 KKDIDDLEL----TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKV---ESFAVTERQLTLEVER--MRLEHGIKRRD 437
D+L + D V+ L + K +L ++V E E++L +++ER +LE +K
Sbjct: 1013 LDDLQAEED---KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 438 RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSE 497
S + IE E+ ++L++ + E + S+
Sbjct: 1070 ES-------IMDIENEKQQLDEKLKKKEF-----------------------EISNLQSK 1099
Query: 498 IHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQT 557
I +LQ+ ++ + +E+++ ++ A R K ++ EL + + +
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1159
Query: 558 TAPHNIVSLMEKEKELALSDLRRIMAEKEALRE------KLEHIEEVSLFGKSELEKTIE 611
+ M K++E +RR + E E + +H + V +EL + I+
Sbjct: 1160 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV-----AELGEQID 1214
Query: 612 HLTCVNHQLESEKYELKSKVLIMKETIE-------SLENKLKVQAQKFSHVAGDSSHQKT 664
+L V +LE EK E+K ++ + +E +LE + + S + Q+
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQR 1274
Query: 665 EVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHV 724
+N L +LQ ++ +L K + + ++I+EL ++ + + +
Sbjct: 1275 LINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNA 1334
Query: 725 MKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKET 784
+ + + D L+E +E+ E A LQ L+ VAQ + ++ E+ Q E
Sbjct: 1335 LAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR---TKYETDAIQRTEE 1391
Query: 785 LVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAA 844
L ++ L ++L AA + ++ V K +RLQ+++ + + + + A
Sbjct: 1392 LEEAKKK---LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 845 VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904
+++ + ++ + + + A +KE + L + N E+ + + E+
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 905 SSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQE 964
+++ E+ + + +R+ LEK I++ + E + + A+ E L H+E
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEK-IKKQV------EQEKCELQAALEEAEASLEHEE 1561
Query: 965 DEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELEN-----VKSESDL- 1018
+ + +L+ ++ + + KD QL ++ R+V +++ ++S +D
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI---RIVESMQSTLDAEIRSRNDAI 1618
Query: 1019 -LKKQLS---NERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQL---LKEKLTLSESK 1071
LKK++ NE N + +A + + + KDT+I L L+ + L E +
Sbjct: 1619 RLKKKMEGDLNEMEIQLNHANRMAAEALRNYR-NTQGILKDTQIHLDDALRSQEDLKE-Q 1676
Query: 1072 LTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQE 1113
L R +L+A++ +L+ + E+ ER R I E
Sbjct: 1677 LAMVERRANLLQAEIEELRA---------TLEQTERSRKIAE 1709
Score = 135 bits (339), Expect = 3e-31
Identities = 230/1127 (20%), Positives = 463/1127 (41%), Gaps = 182/1127 (16%)
Query: 5 VERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKA---EKES 61
+E K + + K + L + E L E+ L+ T L ++K+ V ++E
Sbjct: 879 LEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQL-EAKIKEVTERAEDEEE 937
Query: 62 ANFDFVLEPYKLEN--ARLSRENNELYLELMKLREH---SDQHVKELKTSL----KKCAR 112
N + + KLE+ + L ++ ++L L L K+ + ++ VK L + + A+
Sbjct: 938 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 997
Query: 113 ETADLKFLNNQYAHKLKLLEKE-------SKAKNERIQQL--------QEKNLHAVVQTP 157
T + K L + L L+ E +KAK + QQ+ QEK L ++
Sbjct: 998 LTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA 1057
Query: 158 GGKKRS---------IAFRRQRMQIDEPVPPSE--VSSYPVPQPDDPYIADLLQVADNRI 206
K + ++ Q+DE + E +S+ D+ + LQ +I
Sbjct: 1058 KRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ---KKI 1114
Query: 207 QELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALD---GGRSPDVLSLESRN 263
+ELQ + +L+E++ + KQ RE+E +S L+ G S + + R
Sbjct: 1115 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1174
Query: 264 KTNEKL-------------------------IAHLNIQVDFLQQANKDLEKRIRELMETK 298
+K+ +A L Q+D LQ+ + LEK E+
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI 1234
Query: 299 ETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEM 358
+ + S V +S L E++ T + +L E K + + + +
Sbjct: 1235 DDLASNVETVSKAKGNL------------------EKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 359 QDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTER 418
DL +LQ E E R DE E +V QL + KQ ++++E +R
Sbjct: 1277 NDLTAQRGRLQTE----SGEFSRQLDE------KEALVSQLSRGKQAFTQQIEEL---KR 1323
Query: 419 QLTLEVE-RMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSY 477
QL E++ + L H ++ S D + EEE++ K EL+R
Sbjct: 1324 QLEEEIKAKNALAHALQ---SSRHDCDLLREQYEEEQE-SKAELQR-----------ALS 1368
Query: 478 SAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLS 537
A + + +RT + D ++ + +L + L+ E+++E + N K + E+ K
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV--NAKCASLEKTK-- 1424
Query: 538 VLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRR----IMAEKEALREKLE 593
Q E+ L + +T A + ++ + L++ ++ AE EA +++
Sbjct: 1425 ---QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEAR 1481
Query: 594 HIEEVSLFGKSELEKTIEHLTCV---NHQLESEKYELKSKVLIMKETIESLENKLKVQAQ 650
+ K+ E++++ L + N L+ E +L ++ + I LE K+K Q +
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVE 1540
Query: 651 K--------FSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQA-QI 701
+ H++ ++ +++ Q++ VD +++ K E++ + I
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEIDQLKRNHI 1597
Query: 702 KILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKE 761
+I+E L+ ++ S+++ + KK G +++ ++ ++ A N N +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE----MEIQLNHANRMAAEALRNYRNTQ 1653
Query: 762 KAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKE-- 819
+ +I + + S LKE L +R N L+ +++ L++ RSR+IA +E
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL 1713
Query: 820 ------------NRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWES 867
N L + + + ++ E+E +QE + + K IT+ +
Sbjct: 1714 DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA----A 1769
Query: 868 LMAAKEKENQDL---LDRFQM-LHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRE 923
+MA + K+ QD L+R + + +D +++ +AE +L L + + L
Sbjct: 1770 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE------QLALKGGKKQIQKLEA 1823
Query: 924 RVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIK 983
RV LE E++ + + + K R++E E+++ +L + +L K
Sbjct: 1824 RVRELEGEVESEQKRN---AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAK 1880
Query: 984 LDSGK---DIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNER 1027
+ S K + +Q N+ +F ++ ELE + +D+ + Q++ R
Sbjct: 1881 VKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 139 bits (349), Expect = 2e-32
Identities = 203/965 (21%), Positives = 398/965 (41%), Gaps = 121/965 (12%)
Query: 212 EVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIA 271
+VH+L+++ ++S + D + ++ IE L VL + + NE A
Sbjct: 379 KVHELEKENLQLKSKLHDLELDRDTDKKRIEELL------EENMVLEIAQKQSMNES--A 430
Query: 272 HLNIQVDFLQQANKDLEKRIRE--LMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQL 329
HL +++ L + N DL R+ + E E +S ++ L +N+ L Q Q
Sbjct: 431 HLGWELEQLSK-NADLSDASRKSFVFELNECASSRILKLEKENQSL--------QSTIQG 481
Query: 330 ERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVK 389
R VLE + + GE +KE L + + KLQ +L E+E+ S++
Sbjct: 482 LRDASLVLEESGLKCGELEKE-------NHQLSKKIEKLQTQL-----EREKQSNQ---- 525
Query: 390 SDLETVVHQLEQEKQRLSKKVESFAVTE-RQLT-LEVERMRLEHGI-KRRDRSPSRLDTF 446
DLET+ +L +EK++L +E+ + RQ+ LE E+ L + R+RS +
Sbjct: 526 -DLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEAR 584
Query: 447 LKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERD 506
+K +E KE + L + + S EK + R E+ E +
Sbjct: 585 MKDVE-------KENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGE------RAE 631
Query: 507 ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQE---ELSALRKE-STQTTAPHN 562
+L+R L+R ++ + V L +K+ L +E+Q E LRK T
Sbjct: 632 KLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQ 691
Query: 563 IVSLMEKEKELALS--DLRRIMAEKEALREKLEHIEEVSLF---GKSELEKTIEHLTCV- 616
+ L K+L +LRR++ KL +E + K EL K ++ L +
Sbjct: 692 LEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALG 751
Query: 617 --NHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNE 674
+ +LE + ++ L +++++ES +K + + + + + ++ +LR+ N
Sbjct: 752 KKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANA 811
Query: 675 QLQRSVDDYQHRLSIKRGELESAQAQI----KILEEKIDELNLKMTSQDEEAHVMKKTIG 730
QL+ + D R LE AQ+ K+LE++ L ++ +D +
Sbjct: 812 QLEGAEKD--------RKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLS 863
Query: 731 VIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDR 790
++KE +D++ + + L EK + ++ ++ L+E LV
Sbjct: 864 AVEKES----RALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKL 919
Query: 791 EINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDL-------------ATMARENQEI 837
+ L +LD +EL++VG +RE+ +E+ D T+A + ++I
Sbjct: 920 KSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKI 979
Query: 838 SLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQ-------MLHNRA 890
L LEA ++EK + ++ + + + + + E Q L + F+ H
Sbjct: 980 VL-LEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGK 1038
Query: 891 EDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMA 950
E W +A E V+ + ++ L+ +LL++++Q + + SQI ++
Sbjct: 1039 EAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQ 1098
Query: 951 KAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELE 1010
K + L+E + + A + + S+L L + ++ +K E E + + E
Sbjct: 1099 KQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQE 1158
Query: 1011 NVKSESDLL-----------KKQLSNERHTVKNLESLLATNRDKEF-HSHLTSHEKD--- 1055
+ + + L ++Q + ++ L +R+ E H L D
Sbjct: 1159 QLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLK 1218
Query: 1056 --TEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDA---LKRQISTERYERERA 1110
E++ ++ LT L + R N + + +L+ + D L Q+ E E
Sbjct: 1219 RKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAH 1278
Query: 1111 IQEMR 1115
+E++
Sbjct: 1279 TKELK 1283
Score = 136 bits (343), Expect = 1e-31
Identities = 235/1100 (21%), Positives = 445/1100 (40%), Gaps = 121/1100 (11%)
Query: 45 ESLRQSKLSAVKAEKESANFDFVLEPYKLENARLS--RENNELYLELMKLREHSDQHVKE 102
+SLR+ + E E L AR+ RE+N + +E + E E
Sbjct: 316 DSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLE-------E 368
Query: 103 LKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKR 162
T+ + + +L+ N Q KL LE + +RI++L E+N+ +
Sbjct: 369 QLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNE 428
Query: 163 SIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQEKLAM 222
S + Q+ + S+ S ++ +L + A +RI +L++E LQ +
Sbjct: 429 SAHLGWELEQLSKNADLSDASR-------KSFVFELNECASSRILKLEKENQSLQSTI-- 479
Query: 223 MESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFLQQ 282
G+RD S +E L G LE N K I L Q++ +Q
Sbjct: 480 --QGLRDASLVLE---------ESGLKCG------ELEKENHQLSKKIEKLQTQLEREKQ 522
Query: 283 ANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQEL-TEIDQLAQQLERHKEEVLETAD 341
+N+DLE EL+ KE + S++ L + ++L E D L + + +E +++
Sbjct: 523 SNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSE 582
Query: 342 KELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQ 401
+ + +KE K + + +++L+ E ++ E+ ++ LE + +L++
Sbjct: 583 ARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQE 642
Query: 402 EKQRLSKKVESF-AVTERQLTLEVER--MRLEHGIKRRDRSP-SRLDTFLKGIEEER--- 454
E RL++KV S TE+ LE E ++LE+ R+ + L+G+E +
Sbjct: 643 ENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQL 702
Query: 455 DYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEI---------------H 499
D EL RL ++ S + RE + R E+ N ++
Sbjct: 703 DAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQ 762
Query: 500 QITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQ--- 556
++ E LQ+ LE + ++S + L AER L + +L ALR + Q
Sbjct: 763 SVSAENLRLQQSLESSSHKTQTLESELGELEAERQAL-------RRDLEALRLANAQLEG 815
Query: 557 ----TTAPHNIVSLMEKEKELALSDLRRIMAE---KEALRE----KLEHIEEVSLFGKSE 605
A V+ +EK+K+L + +R+ + K+A+ + KL +E+ S E
Sbjct: 816 AEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKE 875
Query: 606 LEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTE 665
L + + + +LE + +L +V + T+ +L L ++ K ++ + E
Sbjct: 876 LARCRDAAGKLK-ELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934
Query: 666 VNSLRIVNEQLQRSVDD-YQHRLSIKRGELESA-QAQIKILEEKIDELNLKMTSQDEEAH 723
+ + + E L + D + I G ESA + + + EEKI L +M +
Sbjct: 935 LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994
Query: 724 VMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIM----ISECESSVN 779
++ + ++ KE + L++ E + + N ++ A K A Q K E +
Sbjct: 995 QLESELQMLKKECETLRQNQGE-GQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELL 1053
Query: 780 QLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISL 839
++K+ + +R +L+ + ++L + + LQ A + N +
Sbjct: 1054 RVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQT 1113
Query: 840 ELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQ 899
+ E + S+ + + ++ AKE EN+ L R Q A + ++ H+
Sbjct: 1114 QTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENES-LQRQQEQLTAAYEALLQDHE 1172
Query: 900 AEG---ESSSVRLE-LLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSR 955
G E S E L+ + + L +EL KE+ E ++++ K ++
Sbjct: 1173 HLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTT 1232
Query: 956 LEEELRHQEDEKATVLNDLSSLRELCIKLD---------------SGKDIMTQQLNSKNL 1000
E L+ ++ A + + LR +++ K++ T LN+ L
Sbjct: 1233 EREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKT-SLNNAQL 1291
Query: 1001 EFERVVVELENVKSESDLLKKQLSN-ERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQ 1059
E R + +K + + L+ + H L S L N ++E H HL S +IQ
Sbjct: 1292 ELNRWQARFDELKEQHQTMDISLTKLDNHC--ELLSRLKGNLEEENH-HLLS-----QIQ 1343
Query: 1060 LLKEKLTLSESKLTSQSREN 1079
LL ++ L Q+ EN
Sbjct: 1344 LLSQQ----NQMLLEQNMEN 1359
Score = 129 bits (323), Expect = 2e-29
Identities = 215/999 (21%), Positives = 419/999 (41%), Gaps = 162/999 (16%)
Query: 47 LRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLREHSDQHVKELKTS 106
L +S L + EKE+ +E + + R + N +L +L +Q +++T
Sbjct: 489 LEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETL 548
Query: 107 LKKCARETADLKFLNNQYAHKLKLLEKESKAKNE-RIQQLQEKN--LHAVVQTPGGKKRS 163
AR+ DL+ + + L + S+ +E R++ ++++N LH V GK
Sbjct: 549 KADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQ 608
Query: 164 IAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE---KL 220
+ F ++++ D + + R ++L++E+ +LQE +L
Sbjct: 609 LEFEKRQLHRD---------------------LEQAKEKGERAEKLERELQRLQEENGRL 647
Query: 221 AMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESRN-KTNEKLIAHLNIQVDF 279
A + + ++++E E E + L LE+R + + + ++++Q++
Sbjct: 648 ARKVTSLETATEKVEALEHESQG-------------LQLENRTLRKSLDTLQNVSLQLEG 694
Query: 280 LQQANKDLEK---RIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEV 336
L++ NK L+ +R L+ET ++++ + +N QQLER KEE+
Sbjct: 695 LERDNKQLDAENLELRRLVETMRFTSTKLAQMEREN--------------QQLEREKEEL 740
Query: 337 LETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVV 396
+ D KK + +LS Q + +LQ L + + L EL
Sbjct: 741 RKNVDLLKALGKKSERLELS-YQSVSAENLRLQQSLESSSHKTQTLESEL---------- 789
Query: 397 HQLEQEKQRLSKKVESFAVTERQLT-LEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERD 455
+LE E+Q L + +E+ + QL E +R LE + + +E+++
Sbjct: 790 GELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQ--------------LEKDKK 835
Query: 456 YYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERF 515
+KE +RL ++ + S + S++ + D ++ R RD + L+
Sbjct: 836 LLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALD-----KELARCRDAAGK-LKEL 889
Query: 516 EKYMEDIQSNV----KLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEK 571
EK D+ V + LT R+ L + ++Q+ S L K S + L+ +E
Sbjct: 890 EKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQED 949
Query: 572 ELALSDLRRIM--AEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKS 629
+ +I+ + AL+ L EE + LE +E +N QLESE LK
Sbjct: 950 DSGSDTKYKILEGRNESALKTTLAMKEEKIVL----LEAQMEEKASLNRQLESELQMLKK 1005
Query: 630 KVLIMKETIESLENKLKVQAQKFSHVAGD--SSHQKTEV--NSLRIVNEQLQRSVDDYQH 685
+ ET+ + + + F H AG +SHQ E + +L R D
Sbjct: 1006 EC----ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKD---R 1058
Query: 686 RLSIKRGELESAQAQIKILEEKIDEL---NLKMTSQDEEAHVMKKTIGVIDKEKDFLQE- 741
+ ++R + QA+ ++L+E++ L N+ +SQ I + K+ FLQE
Sbjct: 1059 AIELERNN-AALQAEKQLLKEQLQHLETQNVTFSSQ----------ILTLQKQSAFLQEH 1107
Query: 742 --TVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQL 799
T+ +T K+ L+++ A+ ++ ++ E+L + ++ + L
Sbjct: 1108 NTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEAL 1167
Query: 800 DAAHKELDEVGRSREIAFKENRRLQDDLATMAR----ENQEIS------LELEAAVQEKE 849
H+ L + + ++ R L T+ R E++E+ L+ +A ++E+E
Sbjct: 1168 LQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEERE 1227
Query: 850 EMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHN--RAEDWEVKAHQAEGESS-- 905
++ + + + + R +L + + + LDR LH+ + E E+ AH E ++S
Sbjct: 1228 KVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLN 1287
Query: 906 SVRLEL--------------LSIDTERRHLRERVELLE--KEIQEHINAHHAYESQISSM 949
+ +LEL ++D L ELL K E N H + Q+ S
Sbjct: 1288 NAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQ 1347
Query: 950 AKAMSRLEEELRHQE---DEKATVLNDLSSLRELCIKLD 985
M LE+ + ++E +E+ ++ L++LR KL+
Sbjct: 1348 QNQM-LLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLE 1385
Score = 128 bits (321), Expect = 4e-29
Identities = 208/1019 (20%), Positives = 414/1019 (40%), Gaps = 200/1019 (19%)
Query: 45 ESLRQSKLSAVKAEKESANFDFVLEPYKLENARLSRENNELYLELMKLR---EHSDQHVK 101
E QS S ++ ++++ VLE L+ L +EN++L ++ KL+ E Q +
Sbjct: 469 EKENQSLQSTIQGLRDAS---LVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQ 525
Query: 102 ELKTSLKKCARET----ADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEKN-------- 149
+L+T ++ RE +D++ L A ++K LE+E N + L+E++
Sbjct: 526 DLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARM 585
Query: 150 ---------LHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQ 200
LH V GK + F ++++ D + +
Sbjct: 586 KDVEKENKALHQTVTEANGKLSQLEFEKRQLHRD---------------------LEQAK 624
Query: 201 VADNRIQELQQEVHQLQE---KLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVL 257
R ++L++E+ +LQE +LA + + ++++E E E + L
Sbjct: 625 EKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQ------------ 672
Query: 258 SLESRN-KTNEKLIAHLNIQVDFLQQANKDLEKR---IRELMETKETVTSEVVNLSNKNE 313
LE+R + + + ++++Q++ L++ NK L+ +R L+ET ++++ + +N
Sbjct: 673 -LENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMEREN- 730
Query: 314 KLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELN 373
QQLER KEE+ + D KK + +LS Q + +LQ L
Sbjct: 731 -------------QQLEREKEELRKNVDLLKALGKKSERLELS-YQSVSAENLRLQQSLE 776
Query: 374 LCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLT-LEVERMRLEHG 432
+ + L EL +LE E+Q L + +E+ + QL E +R LE
Sbjct: 777 SSSHKTQTLESEL----------GELEAERQALRRDLEALRLANAQLEGAEKDRKALEQE 826
Query: 433 IKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKG 492
+ + +E+++ +KE +RL ++ + S + S++ +
Sbjct: 827 VAQ--------------LEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL 872
Query: 493 DYNSEIHQITRERDELQRMLERFEKYMEDIQSNV----KLLTAERDKLSVLYNEAQEELS 548
D ++ R RD ++ E EK D+ V + LT R+ L + ++Q+ S
Sbjct: 873 D-----KELARCRDAAGKLKE-LEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSS 926
Query: 549 ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMA--EKEALREKLEHIEEVSLFGKSEL 606
L K S + L+ +E + +I+ + AL+ L EE + L
Sbjct: 927 ELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVL----L 982
Query: 607 EKTIEHLTCVNHQLESEKYELKSKVLIMKETI---ESLENKLKVQAQKF--SHVAGDS-- 659
E +E +N QLESE LK + +++ + L+N K A K SH ++
Sbjct: 983 EAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWG 1042
Query: 660 -SHQKTEVNSLRIVNE--QLQRSVDDYQHRLSIKRGELESAQ-------AQIKILEEK-- 707
H++ + LR+ + +L+R+ Q + + +L+ + +QI L+++
Sbjct: 1043 PGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSA 1102
Query: 708 -IDELNLKMTSQDEEAHVMKKTIG----VIDKEKDFLQE---TVDEKTEKIANLQENLAN 759
+ E N + +Q + V T+ + + LQ + + E + QE L
Sbjct: 1103 FLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTA 1162
Query: 760 KEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDE----------- 808
+A+ Q + + E L+ + + +L R L+ HKEL E
Sbjct: 1163 AYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAE 1222
Query: 809 -----------------VGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEM 851
R+ +A EN+RL+ +L + + ++ E E +E+
Sbjct: 1223 LEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKEL 1282
Query: 852 KSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLEL 911
K+ ++ E++RW++ RF L + + ++ + + +
Sbjct: 1283 KTSLNNAQLELNRWQA--------------RFDELKEQHQTMDISLTKLDNHCELLSRLK 1328
Query: 912 LSIDTERRHLRERVELLEKEIQ-------EHINAHHAYESQISSMAKAMSRLEEELRHQ 963
+++ E HL +++LL ++ Q E+ +H + Q A+ R +E+L +
Sbjct: 1329 GNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEK 1387
Score = 118 bits (296), Expect = 3e-26
Identities = 203/953 (21%), Positives = 387/953 (40%), Gaps = 177/953 (18%)
Query: 283 ANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETADK 342
+++D + EL +TK + L +K E+L E+DQL +L++ K+E ++ A
Sbjct: 245 SSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAAD 304
Query: 343 ELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETV------- 395
+ + + +L +++ + +L+LEL C KE+L D K+ +E +
Sbjct: 305 --ARSARAYRDELDSLREKANRVERLELELTRC---KEKLHDVDFYKARMEELREDNIIL 359
Query: 396 --------------------VHQLEQEKQRLSKKVESF------------AVTERQLTLE 423
VH+LE+E +L K+ + E + LE
Sbjct: 360 IETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLE 419
Query: 424 VERMR-----------LEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRS 472
+ + + LE K D S + +F+ + E +LE+ +Q
Sbjct: 420 IAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQ--- 476
Query: 473 CSTSYSAREKSSIFRTP--EKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLT 530
ST R+ S + + G+ E HQ++++ ++LQ LER ++ +D+++ + L
Sbjct: 477 -STIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELI 535
Query: 531 AERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALRE 590
E+++L Q ++ L+ + + + +E+EK+ L R M +LRE
Sbjct: 536 REKEQL-------QSDMETLKADKARQ------IKDLEQEKD----HLNRAM---WSLRE 575
Query: 591 KLEHIEEVSLFG----KSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLK 646
+ + E + L +T+ QLE EK +L + KE E E KL+
Sbjct: 576 RSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAE-KLE 634
Query: 647 VQAQKFSHVAGDSSHQKT--------------EVNSLRIVNEQLQRSVDDYQHRLSIKRG 692
+ Q+ G + + T E L++ N L++S+D Q+ +S++
Sbjct: 635 RELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQN-VSLQLE 693
Query: 693 ELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIAN 752
LE Q+ ++ L M + M++ +++EK+ L++ VD + +
Sbjct: 694 GLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVD-LLKALGK 752
Query: 753 LQENLANKEKAVAQMKIMISECESSVNQLKETLVNR----DREINSLRRQLDA---AHKE 805
E L ++V+ + + + S + +TL + + E +LRR L+A A+ +
Sbjct: 753 KSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ 812
Query: 806 LDEVGRSREIAFKENRRLQDDLATMARENQEI--SLELEAAVQEKE-------EMKSR-V 855
L+ + R+ +E +L+ D + +E + + +EL+ AV + E +SR +
Sbjct: 813 LEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL 872
Query: 856 HKYITEVSRWESLMAAKEKENQDLLDRF----QMLHNRAEDW---EVKAHQAEGESSSVR 908
K + + EK+N+DL + + L ED ++K+ Q E +
Sbjct: 873 DKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLS 932
Query: 909 LELLSIDTERRHL------------------------------RERVELLEKEIQEHINA 938
EL + R L E++ LLE +++E +
Sbjct: 933 QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASL 992
Query: 939 HHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSK 998
+ ES++ + K E LR + E + N GK+
Sbjct: 993 NRQLESELQMLKKEC----ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEA 1048
Query: 999 NLEFERV---VVELEN----VKSESDLLKKQLSN-ERHTVKNLESLLATNRDKEFHSHLT 1050
+E RV +ELE +++E LLK+QL + E V +L + F
Sbjct: 1049 TMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAF----- 1103
Query: 1051 SHEKDTEIQLLKEKLTLSESKLTSQS----RENTMLRAKVAQLQTDYDALKRQ 1099
E +T +Q KL + S L+SQS + T+L+ +T+ ++L+RQ
Sbjct: 1104 LQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQ 1156
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 137 bits (344), Expect = 8e-32
Identities = 239/1144 (20%), Positives = 472/1144 (41%), Gaps = 216/1144 (18%)
Query: 5 VERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKA---EKES 61
+E K + + + + L + + L E+ L+ T L ++K+ V ++E
Sbjct: 877 LEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQL-EAKIKEVTERAEDEEE 935
Query: 62 ANFDFVLEPYKLEN--ARLSRENNELYLELMKLREH---SDQHVKELKTSL----KKCAR 112
N + + KLE+ + L ++ ++L L L K+ + ++ VK L + + A+
Sbjct: 936 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 995
Query: 113 ETADLKFLNNQYAHKLKLLEKE-------SKAKNERIQQL--------QEKNLHAVVQTP 157
T + K L + L L+ E +KAK + QQ+ QEK L ++
Sbjct: 996 LTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055
Query: 158 GGK---------KRSIAFRRQRMQIDEPVPPSE--VSSYPVPQPDDPYIADLLQVADNRI 206
K + ++ + Q++E + E +S+ D+ +A LQ +I
Sbjct: 1056 KRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQ---KKI 1112
Query: 207 QELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALD---GGRSPDVLSLESRN 263
+ELQ + +L+E++ + KQ RE+E +S L+ G S + + R
Sbjct: 1113 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1172
Query: 264 KTNEKL-------------------------IAHLNIQVDFLQQANKDLEKRIREL-MET 297
+K+ +A L Q+D LQ+ + LEK EL ME
Sbjct: 1173 AEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEI 1232
Query: 298 KETVTS-EVVNLSNKN-EKLCQELTEIDQLAQQLERHKEEVLETADKELGEAKKEIKRKL 355
+ ++ E V+ + N EK+C+ L DQL+ EIK K
Sbjct: 1233 NDLASNMETVSKAKANFEKMCRTLE--DQLS-----------------------EIKTKE 1267
Query: 356 SEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAV 415
E Q L ++ + L+ E R DE + +V QL + KQ ++++E
Sbjct: 1268 EEQQRLINELSAQKARLHTESGEFSRQLDE------KDAMVSQLSRGKQAFTQQIEEL-- 1319
Query: 416 TERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCST 475
+ +LE K + L + + R+ Y++E E + + S +
Sbjct: 1320 ----------KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKAN 1369
Query: 476 SYSAR-----EKSSIFRTPEKGDYNSEIHQITRERDE-----------LQRMLERFEKYM 519
S A+ E +I RT E + ++ Q ++ +E L++ +R + +
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEV 1429
Query: 520 EDIQSNVKLLTA--------ERDKLSVL------YNEAQEELSALRKESTQTTAPHNIVS 565
ED+ +V+ A +R+ VL Y E Q EL A +KES + +
Sbjct: 1430 EDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTE---LF 1486
Query: 566 LMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKY 625
++ E +L L + E + L++++ + E +E K I L V QL+ EK
Sbjct: 1487 KVKNAYEESLDHLETLKRENKNLQQEISDLTEQI----AEGGKHIHELEKVKKQLDHEKS 1542
Query: 626 ELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQH 685
EL++ ++E SLE H++ ++ +++ Q++ +D
Sbjct: 1543 ELQTS---LEEAEASLE------------------HEEGKILRIQLELNQVKSEID---R 1578
Query: 686 RLSIKRGELESAQA-QIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVD 744
+++ K EL+ + ++++E L+ ++ S+++ + KK G +++ ++ ++
Sbjct: 1579 KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNE----MEIQLN 1634
Query: 745 EKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHK 804
+ A NL N + + ++ + + + LKE L +R N ++ +++
Sbjct: 1635 HANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRA 1694
Query: 805 ELDEVGRSREIAFKE--------------NRRLQDDLATMARENQEISLELEAAVQEKEE 850
L+ R R++A +E N L + + + +I E+E VQE
Sbjct: 1695 SLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARN 1754
Query: 851 MKSRVHKYITEVSRWESLMAAKEKENQDL---LDRFQM-LHNRAEDWEVKAHQAEGESSS 906
+ + K IT+ ++MA + K+ QD L+R + + +D +++ +AE
Sbjct: 1755 AEEKAKKAITDA----AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE----- 1805
Query: 907 VRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDE 966
+L L + + L RV LE E++ H E+ + + K R++E E++
Sbjct: 1806 -QLALKGGKKQIQKLEARVRELESEVES--EQKHNVEA-VKGLRKHERRVKELTYQTEED 1861
Query: 967 KATVLNDLSSLRELCIKLDSGK---DIMTQQLNSKNLEFERVVVELENVKSESDLLKKQL 1023
+ +L + +L K+ + K + +Q N +F ++ ELE K +D+ + Q+
Sbjct: 1862 RKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQV 1921
Query: 1024 SNER 1027
+ R
Sbjct: 1922 NKLR 1925
Score = 132 bits (332), Expect = 2e-30
Identities = 193/979 (19%), Positives = 389/979 (39%), Gaps = 131/979 (13%)
Query: 203 DNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+ + +++E + +E+LA E+ K+ EL E+ + + D L+ +
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEA------KRKELEEKMVTLMQEKND---------LQLQ 894
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
+ +A + D L + LE +I+E+ E E L+ K KL E +E+
Sbjct: 895 VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K EM L+ET+AKL E Q+ ++
Sbjct: 955 KKDIDDLEL----TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT---ERQLTLEVERMR--LEHGIKRRD 437
D+L ++ D V+ L + K +L ++V+ + E++L +++ER + LE +K
Sbjct: 1011 LDDLQMEEDK---VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ 1067
Query: 438 RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSE 497
S + + + E+ + E+ LQ I+ D +
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE-----------------------DEQAL 1104
Query: 498 IHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQT 557
Q+ ++ ELQ +E E+ +E +++ +R LS E +E L + T
Sbjct: 1105 AIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS---RELEEISERLEEAGGAT 1161
Query: 558 TAPHNIVSLMEKEKELALSDLRRIMAEKEALREKL--EHIEEVSLFGKSELEKTIEHLTC 615
+A + E E + DL + EA L +H + V+ EL + I+ L
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVA-----ELGEQIDSLQR 1216
Query: 616 VNHQLESEKYELKSKVLIMKETIESL-------ENKLKVQAQKFSHVAGDSSHQKTEVNS 668
V +LE EK ELK ++ + +E++ E + + S + Q+ +N
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE 1276
Query: 669 LRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKT 728
L +L ++ +L K + + ++I+EL ++ + + +
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHA 1336
Query: 729 IGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMIS--------ECESSVNQ 780
+ + D L+E +E+ E A LQ ++ VAQ + E E + +
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 781 LKETLVNRDREINSLRRQLDAAHKE-----------LDEVGRSREIAF---KENRRLQDD 826
L + L + + + ++ + + K + +V RS K+ R
Sbjct: 1397 LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKV 1456
Query: 827 LATMARENQEISLELEAAVQEKEEMKSRVHK----YITEVSRWESLMAAKEKENQDLLD- 881
LA ++ +E ELEA+ +E + + + K Y + E+L + Q++ D
Sbjct: 1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516
Query: 882 -----------------RFQMLHNRAE------DWEVKAHQAEGESSSVRLELLSIDTE- 917
+ Q+ H ++E + E EG+ ++LEL + +E
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 918 RRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSL 977
R + E+ E L++ + H+ + SM S L+ E+R + D L
Sbjct: 1577 DRKIAEKDEELDQLKRNHLRV-------VESM---QSTLDAEIRSRNDALRIKKKMEGDL 1626
Query: 978 RELCIKLDSGKDIMTQQL-NSKNLE--FERVVVELENVKSESDLLKKQLSNERHTVKNLE 1034
E+ I+L+ + L N +N + + + L++ D LK+QL+ ++
Sbjct: 1627 NEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQ 1686
Query: 1035 SLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYD 1094
+ + R + + E+ E++ L ++ TS L ++Q+Q + +
Sbjct: 1687 AEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 1095 ALKRQISTERYERERAIQE 1113
+ ++ + ++AI +
Sbjct: 1747 DIVQEARNAEEKAKKAITD 1765
Score = 121 bits (304), Expect = 3e-27
Identities = 173/882 (19%), Positives = 356/882 (40%), Gaps = 125/882 (14%)
Query: 282 QANKDLEKRIRELMETKETVTSE-----------VVNLSNKNEKLCQELTEIDQLAQ--- 327
+ K++ E +TKE + V + KN+ Q E D LA
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 328 ----------QLERHKEEVLETAD------KELGEAKKEIKRKLSEMQ----DLEETMAK 367
QLE +EV E A+ EL K++++ + SE++ DLE T+AK
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 368 LQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERM 427
++ E + + + + L++E+ + L+ + +L +EK+ L + A + L++E
Sbjct: 968 VEKEKHATENKVKNLTEEM---AGLDETIAKLTKEKKALQE-----AHQQTLDDLQMEED 1019
Query: 428 RLEHGIKRRDRSPSRLDTFLKGIEEER------DYYKKELERLQHIIQRRSCSTSYSARE 481
++ K + + ++D +E+E+ + K++LE + Q + T ++
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ 1079
Query: 482 KSSIFRTP--EKGDYNSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVL 539
+ + E + +I +LQ+ ++ + +E+++ ++ A R K
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 540 YNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEK--------EALREK 591
++ EL + + + + M K++E +RR + E ALR+K
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKK 1199
Query: 592 LEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESL-------ENK 644
H + V +EL + I+ L V +LE EK ELK ++ + +E++ E
Sbjct: 1200 --HADSV-----AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252
Query: 645 LKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKIL 704
+ + S + Q+ +N L +L ++ +L K + +
Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312
Query: 705 EEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAV 764
++I+EL ++ + + + + + D L+E +E+ E A LQ ++ V
Sbjct: 1313 TQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372
Query: 765 AQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQ 824
AQ + + + + R E+ +++L +RLQ
Sbjct: 1373 AQWR----------TKYETDAIQRTEELEEAKKKL--------------------AQRLQ 1402
Query: 825 DDLATMARENQE-ISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRF 883
D A E+ E ++ + + + K+ +++ V + +V R + A +K+ ++
Sbjct: 1403 D-----AEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVL 1457
Query: 884 QMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYE 943
+ E+ + + ++ ES S+ EL + + +E L++E +
Sbjct: 1458 AEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLT 1517
Query: 944 SQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQ-QLNSKNLEF 1002
QI+ K + LE+ + + EK+ + L E ++ + GK + Q +LN E
Sbjct: 1518 EQIAEGGKHIHELEKVKKQLDHEKSELQTSLEE-AEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 1003 ERVVVELENVKSESDLLKKQLSNERHTVKNLESLL-----ATNRDKEFHSHLTSHEKDTE 1057
+R + E + E D LK+ N V++++S L + N + + E
Sbjct: 1577 DRKIAEKD---EELDQLKR---NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEME 1630
Query: 1058 IQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQ 1099
IQL +E+ ++ NT K QL D DA++ Q
Sbjct: 1631 IQLNHANRQAAEA---LRNLRNTQGILKDTQLHLD-DAIRGQ 1668
Score = 121 bits (303), Expect = 4e-27
Identities = 188/873 (21%), Positives = 377/873 (43%), Gaps = 109/873 (12%)
Query: 292 RELMETKETVTSEVVNL----SNKNEKLCQELTEIDQLAQQLERHKEEVLETADKELGEA 347
R++ME +E++ N+ + K+ + +I L + E KE + +E +
Sbjct: 806 RKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKE--MANMKEEFEKT 863
Query: 348 KKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLS 407
K+E+ + ++ ++LEE M L E N Q + + +D L +D E QL + K +L
Sbjct: 864 KEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADAL---ADAEERCDQLIKTKIQLE 920
Query: 408 KKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHI 467
K++ VTER + E + E K+R +E+E KK+++ L+
Sbjct: 921 AKIKE--VTER--AEDEEEINAELTAKKRK------------LEDECSELKKDIDDLELT 964
Query: 468 IQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERDELQRMLERFEKYMEDIQ---S 524
+ + A E T E + I ++T+E+ LQ E ++ ++D+Q
Sbjct: 965 LAK--VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ---EAHQQTLDDLQMEED 1019
Query: 525 NVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAE 584
V LT + KL ++ + +L +E +E + +LA +
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLE---GSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEND 1076
Query: 585 KEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENK 644
K+ L EKL+ E F S L+ IE + QL+ + EL++++ ++E IE+ E
Sbjct: 1077 KQQLNEKLKKKE----FEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA-ERA 1131
Query: 645 LKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKIL 704
+ +A+K Q+++ L R +++ RL G + AQI++
Sbjct: 1132 SRAKAEK----------QRSD----------LSRELEEISERLEEAGG---ATSAQIEMN 1168
Query: 705 EEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAV 764
+++ E KM EE+ + + ++K ++V E E+I +LQ EK
Sbjct: 1169 KKREAEFQ-KMRRDLEESTLQHEATAAALRKKH--ADSVAELGEQIDSLQRVKQKLEKEK 1225
Query: 765 AQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQ 824
+++K+ I++ S++ + + N ++ +L QL + +E R + RL
Sbjct: 1226 SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLH 1285
Query: 825 DDLATMARENQE-------ISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQ 877
+ +R+ E +S +A Q+ EE+K ++ + S + + +
Sbjct: 1286 TESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCD 1345
Query: 878 DLLDRFQMLHNRAEDWEVKAHQAEGES---SSVRLELLSIDTERRHLRERVELLEKEIQE 934
L ++++ E+ E KA G S S V +T+ E +E +K++ +
Sbjct: 1346 LLREQYE------EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 935 HINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQ 994
+ + ++S ++ + ++ L+++ ++ ++ D+ CI LD + +
Sbjct: 1400 RLQDAEEHVEAVNSKCASLEKTKQRLQNEVED---LMIDVERSNAACIALDKKQRNFDKV 1456
Query: 995 LNSKNLEFERVVVELENVKSESDLLKKQLSNERHTVKN--------LESLLATNRDKEFH 1046
L ++E ELE + ES + LS E VKN LE+L N++ +
Sbjct: 1457 LAEWKQKYEETQAELEASQKES----RSLSTELFKVKNAYEESLDHLETLKRENKNLQQE 1512
Query: 1047 -SHLTSHEKDT-----EIQLLKEKLTLSESKL-TSQSRENTMLR---AKVAQLQTDYDAL 1096
S LT + E++ +K++L +S+L TS L K+ ++Q + + +
Sbjct: 1513 ISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQV 1572
Query: 1097 KRQISTERYERERAIQEMRRHGL-ATPPLSSTL 1128
K +I + E++ + +++R+ L + STL
Sbjct: 1573 KSEIDRKIAEKDEELDQLKRNHLRVVESMQSTL 1605
Score = 78.2 bits (191), Expect = 4e-14
Identities = 122/563 (21%), Positives = 237/563 (42%), Gaps = 105/563 (18%)
Query: 603 KSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQ 662
K E EKT E L + E+++ EL+ K++ T+ +N L++Q Q + D+ +
Sbjct: 857 KEEFEKTKEELA----KTEAKRKELEEKMV----TLMQEKNDLQLQVQAEADALADAEER 908
Query: 663 -----KTEVNSLRIVNEQLQRSVDDYQ--HRLSIKRGELESAQAQIKILEEKIDELNLKM 715
KT++ + E +R+ D+ + L+ K+ +LE +++K + ID+L L +
Sbjct: 909 CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK---KDIDDLELTL 965
Query: 716 TSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECE 775
++E H + + + +E L ET+ + T++ LQE A Q + E
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE-------AHQQTLDDLQMEE 1018
Query: 776 SSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQ 835
VN L + +++++ L L+ K ++ R++ R+L+ DL Q
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAK-------RKLEGDLKLA----Q 1067
Query: 836 EISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEV 895
E +++ E +K+++ ++ K E+S L + ED +
Sbjct: 1068 ESTMDTE---NDKQQLNEKLKKKEFEMSN---------------------LQGKIEDEQA 1103
Query: 896 KAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSR 955
A Q + + + L+ R+E LE+EI+ + E Q S +++ +
Sbjct: 1104 LAIQ--------------LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 956 LEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSE 1015
+ E L +E AT S+ E+ K ++ M + L L+ E L ++
Sbjct: 1150 ISERL--EEAGGAT-----SAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 1016 S-----------DLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHEKDTEIQLLKEK 1064
S +K++L E+ +K + LA+N + + + EK + L+++
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAK-ANFEK--MCRTLEDQ 1259
Query: 1065 LTLSESKLTSQSRENTMLRAKVAQLQT----------DYDALKRQISTERYERERAIQEM 1114
L+ ++K Q R L A+ A+L T + DA+ Q+S + + I+E+
Sbjct: 1260 LSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL 1319
Query: 1115 RRHGLATPPLSSTLRSPSHSPEH 1137
+R STL S H
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARH 1342
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 136 bits (343), Expect = 1e-31
Identities = 204/981 (20%), Positives = 425/981 (43%), Gaps = 121/981 (12%)
Query: 89 LMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEKESKAKNERIQQLQEK 148
L K + +Q V +L+ SL++ + DL+ + LKL ++ + QQL EK
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEK 1083
Query: 149 NLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQE 208
+ G + + + MQ+ + + + + + + A + A+ + +
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK-AEKQRSD 1142
Query: 209 LQQEVHQLQEKLAMMESGVRDYSKQIEL---REREIERLSVALDGGRSPDVLSLESRNKT 265
L +E+ ++ E+L E S QIE+ RE E +++ L+ + + K
Sbjct: 1143 LSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 266 NEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQL 325
+ +A L Q+D LQ+ + LEK K + E+ +L++ E + + ++++
Sbjct: 1200 HADSVAELGEQIDNLQRVKQKLEKE-------KSEMKMEIDDLASNMETVSKAKGNLEKM 1252
Query: 326 AQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDE 385
+ LE E+ + K+E +++L + DL A+LQ E E R DE
Sbjct: 1253 CRALEDQLSEI---------KTKEEEQQRL--INDLTAQRARLQTE----SGEYSRQLDE 1297
Query: 386 LLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVE-RMRLEHGIKRRDRSPSRLD 444
+T+V QL + KQ ++++E +RQL E++ + L H ++ SR D
Sbjct: 1298 ------KDTLVSQLSRGKQAFTQQIEEL---KRQLEEEIKAKSALAHALQ-----SSRHD 1343
Query: 445 TFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAR-----EKSSIFRTPEKGDYNSEIH 499
L R+ Y++E E + + S + S A+ E +I RT E + ++
Sbjct: 1344 CDLL-----REQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 500 QITRERDE-----------LQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELS 548
Q ++ +E L++ +R + +ED+ +V+ A L + L+
Sbjct: 1399 QRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILA 1458
Query: 549 ALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEK 608
+++ +T H + +KE ++L +I K A E L+ +E + K+ L++
Sbjct: 1459 EWKQKCEET---HAELEASQKESRSLSTELFKI---KNAYEESLDQLETLKRENKN-LQQ 1511
Query: 609 TIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNS 668
I LT + +EL+ +K+ +E +++L+ ++ H++ ++
Sbjct: 1512 EISDLTEQIAEGGKRIHELEK----IKKQVEQEKSELQAALEE---AEASLEHEEGKILR 1564
Query: 669 LRIVNEQLQRSVDDYQHRLSIKRGELESAQA-QIKILEEKIDELNLKMTSQDEEAHVMKK 727
+++ Q++ VD +++ K E++ + I+I+E L+ ++ S+++ + KK
Sbjct: 1565 IQLELNQVKSEVD---RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1621
Query: 728 TIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVN 787
G +++ ++ ++ A N N + + ++ + + S LKE L
Sbjct: 1622 MEGDLNE----MEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAM 1677
Query: 788 RDREINSLRRQLDAAHKELDEVGRSREIAFKE--------------NRRLQDDLATMARE 833
+R N L+ +++ L++ RSR+IA +E N L + + +
Sbjct: 1678 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 834 NQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDL---LDRFQM-LHNR 889
+I E+E +QE + + K IT+ ++MA + K+ QD L+R + L
Sbjct: 1738 ISQIQGEMEDIIQEARNAEEKAKKAITDA----AMMAEELKKEQDTSAHLERMKKNLEQT 1793
Query: 890 AEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSM 949
+D + + +AE +L L + + L RV LE E++ + + +
Sbjct: 1794 VKDLQHRLDEAE------QLALKGGKKQIQKLEARVRELEGEVESEQKRN---VEAVKGL 1844
Query: 950 AKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGK---DIMTQQLNSKNLEFERVV 1006
K +++E E+++ +L + +L K+ S K + +Q N +F R+
Sbjct: 1845 RKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQ 1904
Query: 1007 VELENVKSESDLLKKQLSNER 1027
ELE + +D+ + Q++ R
Sbjct: 1905 HELEEAEERADIAESQVNKLR 1925
Score = 131 bits (330), Expect = 3e-30
Identities = 190/979 (19%), Positives = 390/979 (39%), Gaps = 131/979 (13%)
Query: 203 DNRIQELQQEVHQLQEKLAMMESGVRDYSKQIELREREIERLSVALDGGRSPDVLSLESR 262
+ + +++E + +E+LA E+ K+ EL E+ + + D L+ +
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEA------KRKELEEKMVTLMQEKND---------LQLQ 894
Query: 263 NKTNEKLIAHLNIQVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI 322
+ +A + D L + LE +I+E+ E E L+ K KL E +E+
Sbjct: 895 VQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 323 DQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERL 382
+ LE L +KE + ++K EM L+ET+AKL E Q+ ++
Sbjct: 955 KKDIDDLEL----TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 383 SDELLVKSDLETVVHQLEQEKQRLSKKVESFAVT---ERQLTLEVERMR--LEHGIKRRD 437
D+L + D V+ L + K +L ++V+ + E+++ +++ER + LE +K
Sbjct: 1011 LDDLQAEEDK---VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQ 1067
Query: 438 RSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSE 497
S ++ + ++E+ + E+ LQ I+ D +
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFEMSGLQSKIE-----------------------DEQAL 1104
Query: 498 IHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQT 557
Q+ ++ ELQ +E E+ +E +++ +R LS E +E L + T
Sbjct: 1105 GMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS---RELEEISERLEEAGGAT 1161
Query: 558 TAPHNIVSLMEKEKELALSDLRRIMAEKEALREKL--EHIEEVSLFGKSELEKTIEHLTC 615
+A + E E + DL + EA L +H + V+ EL + I++L
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA-----ELGEQIDNLQR 1216
Query: 616 VNHQLESEKYELKSKVLIMKETIES-------LENKLKVQAQKFSHVAGDSSHQKTEVNS 668
V +LE EK E+K ++ + +E+ LE + + S + Q+ +N
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIND 1276
Query: 669 LRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKT 728
L +LQ +Y +L K + + ++I+EL ++ + + +
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 729 IGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMIS--------ECESSVNQ 780
+ + D L+E +E+ E A LQ ++ VAQ + E E + +
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 781 LKETLVNRDREINSLRRQLDAAHK--------------ELDEVGRSREIAFKENRRLQDD 826
L + L + + + ++ + + K +++ + K+ R
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456
Query: 827 LATMARENQEISLELEAAVQEKEEMKSRVHK----YITEVSRWESLMAAKEKENQDLLDR 882
LA ++ +E ELEA+ +E + + + K Y + + E+L + Q++ D
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516
Query: 883 FQM------------------------LHNRAEDWEVKAHQAEGESSSVRLELLSIDTE- 917
+ L E+ E EG+ ++LEL + +E
Sbjct: 1517 TEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1576
Query: 918 RRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSL 977
R + E+ E +++ + HI + SM S L+ E+R + D L
Sbjct: 1577 DRKIAEKDEEIDQMKRNHIRI-------VESM---QSTLDAEIRSRNDAIRLKKKMEGDL 1626
Query: 978 RELCIKLDSGKDIMTQQL-NSKNLE--FERVVVELENVKSESDLLKKQLSNERHTVKNLE 1034
E+ I+L+ + + L N +N + + + L++ + LK+QL+ L+
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 1035 SLLATNRDKEFHSHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYD 1094
+ + R + + + E+ E++ L ++ TS L ++Q+Q + +
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 1095 ALKRQISTERYERERAIQE 1113
+ ++ + ++AI +
Sbjct: 1747 DIIQEARNAEEKAKKAITD 1765
Score = 125 bits (313), Expect = 3e-28
Identities = 177/901 (19%), Positives = 381/901 (42%), Gaps = 110/901 (12%)
Query: 282 QANKDLEKRIRELMETKETVTSE-----------VVNLSNKNEKLCQELTEIDQLAQ--- 327
+ K++ E +TKE + V + KN+ Q E D LA
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 328 ----------QLERHKEEVLETAD------KELGEAKKEIKRKLSEMQ----DLEETMAK 367
QLE +EV E A+ EL K++++ + SE++ DLE T+AK
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 368 LQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERM 427
++ E + + + + L++E+ + L+ + +L +EK+ L + A + L+ E
Sbjct: 968 VEKEKHATENKVKNLTEEM---AGLDETIAKLTKEKKALQE-----AHQQTLDDLQAEED 1019
Query: 428 RLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELER----LQHIIQRRSCSTSYSAREKS 483
++ K + + ++D L+G E+ + +LER L+ ++ ST +K
Sbjct: 1020 KVNTLTKAKIKLEQQVDD-LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQ 1078
Query: 484 SIFRTPEKGDY-----NSEIHQITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLSV 538
+ +K ++ S+I +LQ+ ++ + +E+++ ++ A R K
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEK 1138
Query: 539 LYNEAQEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALRE------KL 592
++ EL + + + + M K++E +RR + E E +
Sbjct: 1139 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 593 EHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIE-------SLENKL 645
+H + V +EL + I++L V +LE EK E+K ++ + +E +LE
Sbjct: 1199 KHADSV-----AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMC 1253
Query: 646 KVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILE 705
+ + S + Q+ +N L +LQ +Y +L K + +
Sbjct: 1254 RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT 1313
Query: 706 EKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVA 765
++I+EL ++ + + + + + D L+E +E+ E A LQ ++ VA
Sbjct: 1314 QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA 1373
Query: 766 QMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
Q + ++ E+ Q E L ++ L ++L A + ++ V K +RLQ+
Sbjct: 1374 QWR---TKYETDAIQRTEELEEAKKK---LAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 826 DLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQM 885
++ + + + + A +++ + ++ + + + A +KE++ L
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 886 LHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQ 945
+ N E+ + + E+ +++ E+ + + +R+ LEK I++ + E +
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK-IKKQV------EQE 1540
Query: 946 ISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERV 1005
S + A+ E L H+E + + +L+ ++ + + KD Q+ ++ R+
Sbjct: 1541 KSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHI---RI 1597
Query: 1006 VVELEN-----VKSESDL--LKKQLS---NERHTVKNLESLLATNRDKEFHSHLTSHEKD 1055
V +++ ++S +D LKK++ NE N + +A + + + + KD
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR-NTQAILKD 1656
Query: 1056 TEIQL---LKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQ 1112
T++ L L+ + L E +L R +L+A++ +L+ + E+ ER R I
Sbjct: 1657 TQLHLDDALRSQEDLKE-QLAMVERRANLLQAEIEELRA---------TLEQTERSRKIA 1706
Query: 1113 E 1113
E
Sbjct: 1707 E 1707
Score = 120 bits (302), Expect = 6e-27
Identities = 186/838 (22%), Positives = 359/838 (42%), Gaps = 101/838 (12%)
Query: 321 EIDQLAQQLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKE 380
+I L + E KE + +E + K+E+ + ++ ++LEE M L E N Q + +
Sbjct: 839 KIKPLLKSAETEKE--MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896
Query: 381 RLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSP 440
+D L +D E QL + K +L K++ VTER + E + E K+R
Sbjct: 897 AEADSL---ADAEERCDQLIKTKIQLEAKIKE--VTER--AEDEEEINAELTAKKRK--- 946
Query: 441 SRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQ 500
+E+E KK+++ L+ + + A E T E + I +
Sbjct: 947 ---------LEDECSELKKDIDDLELTLAK--VEKEKHATENKVKNLTEEMAGLDETIAK 995
Query: 501 ITRERDELQRMLERFEKYMEDIQSN---VKLLTAERDKLSVLYNEAQEELSALRKESTQT 557
+T+E+ LQ E ++ ++D+Q+ V LT + KL ++ + +L +E
Sbjct: 996 LTKEKKALQ---EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE---GSLEQEKKIR 1049
Query: 558 TAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVN 617
+E + +LA I +K+ L EKL+ E F S L+ IE +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE----FEMSGLQSKIEDEQALG 1105
Query: 618 HQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQ 677
QL+ + EL++++ ++E IE+ E + +A+K Q+++ L
Sbjct: 1106 MQLQKKIKELQARIEELEEEIEA-ERASRAKAEK----------QRSD----------LS 1144
Query: 678 RSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKD 737
R +++ RL G + AQI++ +++ E KM EEA + + ++K
Sbjct: 1145 RELEEISERLEEAGG---ATSAQIEMNKKREAEFQ-KMRRDLEEATLQHEATAATLRKKH 1200
Query: 738 FLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRR 797
++V E E+I NLQ EK ++MK+ I + S++ + + N ++ +L
Sbjct: 1201 --ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED 1258
Query: 798 QLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQE-------ISLELEAAVQEKEE 850
QL + +E R + RLQ + +R+ E +S +A Q+ EE
Sbjct: 1259 QLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 851 MKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLE 910
+K ++ + I S + + + L ++++ + + +A E + R +
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378
Query: 911 LLSIDTER-RHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKAT 969
+ +R L E + L + +Q+ A ++ +S+ K RL+ E+ ED
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV---ED---- 1431
Query: 970 VLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHT 1029
++ D+ C LD + + L + E ELE + ES + LS E
Sbjct: 1432 LMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES----RSLSTELFK 1487
Query: 1030 VKN--------LESLLATNRDKEFH-SHLTSH-----EKDTEIQLLKEKLTLSESKLTSQ 1075
+KN LE+L N++ + S LT ++ E++ +K+++ +S+L +
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 1076 SRENTML----RAKVAQLQTDYDALKRQISTERYERERAIQEMRR-HGLATPPLSSTL 1128
E K+ ++Q + + +K ++ + E++ I +M+R H + STL
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 135 bits (339), Expect = 3e-31
Identities = 239/1225 (19%), Positives = 488/1225 (39%), Gaps = 143/1225 (11%)
Query: 1 MTTAVERKYINIRKRLDQLGYRQTLTVECLPLVEKLFSDLVHTTESLRQSKLSAVKAEKE 60
+ TA E + ++R+R L + L E +E L L E+ ++ S +A++E
Sbjct: 585 LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE 644
Query: 61 SANFDFVLEPYK--LENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLK 118
A +E + +E AR + + + ++L+ S+Q + T ++ A+E L+
Sbjct: 645 KAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ---QKATEKERVAQEKDQLQ 701
Query: 119 FLNNQYAHKLKLLEKESKAKNERIQQLQEKNLHAVVQTPGGKKRSIA-FRRQRMQIDEPV 177
LK+ + + + R E+ + + + + +R+R +++E
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 178 PPSEVSSYPVPQPDDPYIADL-------------LQVADNRIQELQQEVHQLQEKLAMME 224
+ + Q + + A+ A++ ++L +EV +E+ +
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 225 SGVRDYS----KQIELREREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFL 280
Y +Q+ + E E+ L + V +ES ++ ++ Q + L
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK-VAGIESHSELQ------ISRQQNEL 874
Query: 281 QQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETA 340
+ + +L + ++++ E + +LS EK+ E+ +L + L R E ETA
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL-ETLVRKAGEQQETA 933
Query: 341 DKELGEAKKEIKRKLSEMQDLEETMAK----LQLELNLCQKEKERLSDEL------LVKS 390
+EL K+ + + + LEE + Q L ++E E++ +EL L++S
Sbjct: 934 SREL--VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991
Query: 391 D---------LETVVHQLEQEKQR--------------LSKKVESFAVTERQLTLEVERM 427
E V +L QE+ R L ++++ A+ E+++ +
Sbjct: 992 QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQN-ALNEQRVEFATLQE 1050
Query: 428 RLEHGIKRRDRSPSRLDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFR 487
L H + ++ L L+G+E + KELE L+ +++ + +E +S
Sbjct: 1051 ALAHALTEKEGKDQELAK-LRGLEAAQI---KELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 488 TPEKGDYNSEIH--QITRERDELQRMLERFEKYMEDIQSNVKLLTAER-------DKLSV 538
+ +E ++ R E+ ++ ++ +K E S + L AER L
Sbjct: 1107 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET 1166
Query: 539 LYNEAQEELSAL-RKESTQTTAPHNIV---------SLMEKEKELALSDLRRIMAEKEAL 588
L + +E+ L +S +A + S E E + ++ R+ K +L
Sbjct: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
Query: 589 REKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKV- 647
LE EEVS+ + LEK E E ELK V+ E + LE +L++
Sbjct: 1227 ISSLE--EEVSILNRQVLEK------------EGESKELKRLVMAESEKSQKLEERLRLL 1272
Query: 648 ---QAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKIL 704
A + A SS + EV SLR E+ + + ++ + L+ + E ++K
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAW 1332
Query: 705 EEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAV 764
+EK + +++ E + + + K Q+ E+ +E L ++A
Sbjct: 1333 QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA 1392
Query: 765 AQMKIMISECESSVNQL---KETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENR 821
++ + + + +L ++ + ++R LR + + ++L + ++ + +ENR
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 822 RLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLD 881
L + A + R+ E+ L+ Q +E KY+ E L A + L +
Sbjct: 1453 GL-GERANLGRQFLEVELD-----QARE-------KYVQE------LAAVRADAETRLAE 1493
Query: 882 RFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHA 941
+ + A + EV + EG V E ER+ L +VE LE +E
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK---- 1549
Query: 942 YESQISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLE 1001
Q+ ++K ++ ++ + Q+ + V ++ +L + + + QL+ K
Sbjct: 1550 ---QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 1002 FERVVVELENVKSESDLLKKQLSNERHTVKNLESLLATNRDKEFHSHLTSHE------KD 1055
E +++E K+ D K+Q + +++LE L N++ + HE K
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKT 1666
Query: 1056 TEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQLQTDYDALKRQISTERYERERAIQEMR 1115
E + LT L +Q + + Q DALK + + + + +I +
Sbjct: 1667 KEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLD 1726
Query: 1116 RHGLATPPLSSTLRSPSHSPEHRNV 1140
PLS T + P P+ +V
Sbjct: 1727 LSCEEGTPLSITSKLPRTQPDGTSV 1751
Score = 120 bits (302), Expect = 6e-27
Identities = 198/987 (20%), Positives = 418/987 (42%), Gaps = 124/987 (12%)
Query: 161 KRSIAFRRQRMQIDEPVPPSEVSSYPVPQPDDPYIADLLQVADNRIQELQQEV------- 213
KR I F +++ + S +++ P P + D+LQ +++ L++++
Sbjct: 176 KREIRF----LELQKVASSSSGNNFLSGSPASP-MGDILQTPQFQMRRLKKQLADERSNR 230
Query: 214 HQLQEKLAMMESGVRDYSKQIELREREIERLSVALDG-GRSP-DVLSLESRNKTNEKLIA 271
+L+ +LA + + QI + ++ I+RL++ + SP + LE NE L
Sbjct: 231 DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290
Query: 272 HLNI---QVDFLQQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEI-DQLAQ 327
L+ Q L+ ++++I +L E E +LS K + L ++ D L +
Sbjct: 291 RLHETLKQCQDLKTEKSQMDRKINQLSE-------ENGDLSFKLREFASHLQQLQDALNE 343
Query: 328 QLERHKEEVLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDE-L 386
E H + E +K+ + +KE+ L + + LEE LQ +L+ ++ +L D
Sbjct: 344 LTEEHSKATQEWLEKQ-AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402
Query: 387 LVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTLEVERMRLEHGIKRRDRSPSRLDTF 446
K ++ V QLE KQ + + A QL VE + E G +
Sbjct: 403 QEKGEVLGDVLQLETLKQ----EAATLAANNTQLQARVEMLETERGQQEAK--------- 449
Query: 447 LKGIEEERDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEKGDYNSEIHQITRERD 506
+ ER ++++E ++L +I D S I +++ ++
Sbjct: 450 ---LLAERGHFEEEKQQLSSLIT-----------------------DLQSSISNLSQAKE 483
Query: 507 ELQRMLERFEKYMEDIQSNVKLLTAERDKLSVLYNEAQEELSALRKESTQTTAPHNIVSL 566
EL+ + + + + + V LT+E L+ + +EL+ L++++ + A +
Sbjct: 484 ELE---QASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA--QLAQT 538
Query: 567 MEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSELEKTIEHLTCVNHQLESEKYE 626
++++++ + ++ +L++K + ++EV+ K E + +H + E +
Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA--EKQEATRQ-DHAQQLATAAEEREAS 595
Query: 627 LKSKVLIMKETIESLEN----KLKVQAQKFSHVAGDSSHQKTEVNSLRIVNEQLQRSVDD 682
L+ + +K+ +E+LE KL++ Q+ +T V + +L R V++
Sbjct: 596 LRERDAALKQ-LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE 654
Query: 683 YQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQET 742
Q + R E AQAQ+ EL L++ S+ ++A ++ + +EKD LQE
Sbjct: 655 LQACVETARQEQHEAQAQVA-------ELELQLRSEQQKATEKER----VAQEKDQLQEQ 703
Query: 743 VDEKTEKI----ANLQENLANKEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQ 798
+ E + +L+E A+ + + ISE ++ L E +E+ R
Sbjct: 704 LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAG 763
Query: 799 LDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKY 858
L ++G + + E L+ +LA E E V+E + R
Sbjct: 764 RKGLEARLQQLGEAHQ---AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 859 ITEVSRW-----ESLMAAK---EKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLE 910
E +++ E LM K EK Q+L + + + +++H +E + S + E
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG------IESH-SELQISRQQNE 873
Query: 911 LLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKATV 970
L + ++V+ E Q+ + + ++++ +K ++RLE +R +++ T
Sbjct: 874 LAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
Query: 971 LNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLSNERHTV 1030
+L ++E D + + +Q + +F L+ ++ E++ + +L R +
Sbjct: 934 SREL--VKEPARAGDRQPEWLEEQ---QGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
Query: 1031 KNLESLLATNRDKEFH--SHLTSHEKDTEIQLLKEKLTLSESKLTSQSRENTMLRAKVAQ 1088
+ R ++ + LT + L EK +E ++ Q+ N R + A
Sbjct: 989 MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ-RVEFAT 1047
Query: 1089 LQTDYDALKRQISTERYERERAIQEMR 1115
LQ +AL + TE+ +++ + ++R
Sbjct: 1048 LQ---EALAHAL-TEKEGKDQELAKLR 1070
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.326
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,219,154
Number of Sequences: 37866
Number of extensions: 1695835
Number of successful extensions: 27618
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 466
Number of HSP's successfully gapped in prelim test: 1244
Number of HSP's that attempted gapping in prelim test: 8977
Number of HSP's gapped (non-prelim): 7841
length of query: 1140
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1027
effective length of database: 13,968,660
effective search space: 14345813820
effective search space used: 14345813820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.