Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4885349
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
(590 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 1215 0.0
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 848 0.0
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 847 0.0
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 847 0.0
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 795 0.0
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 762 0.0
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 734 0.0
gi|4506529 rhodopsin kinase [Homo sapiens] 521 e-148
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 476 e-134
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 310 3e-84
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 306 4e-83
gi|4506067 protein kinase C, alpha [Homo sapiens] 207 2e-53
gi|4502023 AKT2 kinase [Homo sapiens] 206 4e-53
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 206 4e-53
gi|62241015 AKT1 kinase [Homo sapiens] 204 1e-52
gi|62241013 AKT1 kinase [Homo sapiens] 204 1e-52
gi|62241011 AKT1 kinase [Homo sapiens] 204 1e-52
gi|5453974 protein kinase N2 [Homo sapiens] 204 2e-52
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 204 2e-52
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 204 2e-52
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 203 4e-52
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 199 5e-51
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 199 5e-51
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 197 2e-50
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 195 9e-50
gi|13384594 protein kinase C, gamma [Homo sapiens] 195 1e-49
gi|133908623 protein kinase C, iota [Homo sapiens] 193 4e-49
gi|28557781 protein kinase C, eta [Homo sapiens] 192 9e-49
gi|47157325 protein kinase C, delta [Homo sapiens] 191 1e-48
gi|31377782 protein kinase C, delta [Homo sapiens] 191 1e-48
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 1215 bits (3143), Expect = 0.0
Identities = 590/590 (100%), Positives = 590/590 (100%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
Sbjct: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
Sbjct: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480
Query: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN 540
EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
Sbjct: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN 540
Query: 541 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590
HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
Sbjct: 541 HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS 590
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 848 bits (2190), Expect = 0.0
Identities = 406/573 (70%), Positives = 477/573 (83%), Gaps = 1/573 (0%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I +
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
V + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQP
Sbjct: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
VNS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLE
Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300
Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
DLHRE VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+
Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
RY SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C
Sbjct: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480
LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDI
Sbjct: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480
Query: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-R 539
EQFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ +
Sbjct: 481 EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK 540
Query: 540 NHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTS 572
PP PPKKGLLQRLF RQ ++ + K+S
Sbjct: 541 GQPPAPPKKGLLQRLFSRQRIAVETAATARKSS 573
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 847 bits (2188), Expect = 0.0
Identities = 404/559 (72%), Positives = 471/559 (84%), Gaps = 1/559 (0%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I +
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
V + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQP
Sbjct: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
VNS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLE
Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300
Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
DLHRE VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+
Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
RY SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C
Sbjct: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480
LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDI
Sbjct: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480
Query: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-R 539
EQFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ +
Sbjct: 481 EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK 540
Query: 540 NHPPEPPKKGLLQRLFKRQ 558
PP PPKKGLLQRLF RQ
Sbjct: 541 GQPPAPPKKGLLQRLFSRQ 559
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 847 bits (2188), Expect = 0.0
Identities = 404/559 (72%), Positives = 471/559 (84%), Gaps = 1/559 (0%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I +
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
V + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQP
Sbjct: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEK
Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
VNS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLE
Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300
Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
DLHRE VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+
Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
RY SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C
Sbjct: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480
LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDI
Sbjct: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480
Query: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-R 539
EQFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ +
Sbjct: 481 EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK 540
Query: 540 NHPPEPPKKGLLQRLFKRQ 558
PP PPKKGLLQRLF RQ
Sbjct: 541 GQPPAPPKKGLLQRLFSRQ 559
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 795 bits (2053), Expect = 0.0
Identities = 381/560 (68%), Positives = 458/560 (81%), Gaps = 3/560 (0%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVAN++LLKAR+GG GK+ G+SKKWKEIL P +SQC +LR +I++DY SLCDKQ
Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + +
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179
+ D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299
KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359
EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419
++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479
C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
Query: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNR 539
IEQFS VKG+ LD D+DFY++F+TG VSIPWQNEMIE+ CFK++N LP DL++
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
Query: 540 N--HPPEPPKKGLLQRLFKR 557
N P P +G RLF+R
Sbjct: 541 NIHTPVSRPNRGFFYRLFRR 560
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 762 bits (1968), Expect = 0.0
Identities = 362/515 (70%), Positives = 432/515 (83%), Gaps = 1/515 (0%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVAN++LLKAR+GG GK+ G+SKKWKEIL P +SQC +LR +I++DY SLCDKQ
Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + +
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179
+ D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299
KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359
EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419
++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479
C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
Query: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNE 514
IEQFS VKG+ LD D+DFY++F+TG VSIPWQNE
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 734 bits (1896), Expect = 0.0
Identities = 361/560 (64%), Positives = 433/560 (77%), Gaps = 35/560 (6%)
Query: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
MELENIVAN++LLKAR+ ++DY SLCDKQ
Sbjct: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + +
Sbjct: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
Query: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179
+ D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ
Sbjct: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE
Sbjct: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
Query: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299
KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL
Sbjct: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
Query: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359
EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN
Sbjct: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
Query: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419
++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI
Sbjct: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
Query: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479
C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD
Sbjct: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
Query: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNR 539
IEQFS VKG+ LD D+DFY++F+TG VSIPWQNEMIE+ CFK++N LP DL++
Sbjct: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
Query: 540 N--HPPEPPKKGLLQRLFKR 557
N P P +G RLF+R
Sbjct: 509 NIHTPVSRPNRGFFYRLFRR 528
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 521 bits (1342), Expect = e-148
Identities = 257/540 (47%), Positives = 374/540 (69%), Gaps = 6/540 (1%)
Query: 3 LENIVANTVLLKAREG--GGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
LE +VAN+ + AR G + + KK+ LK P +S+CE LR ++ ++ S+C +Q
Sbjct: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
Query: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
PIG+ LF+QF ++ ++ + +Y+ ++ +K + I+ +YL P++ +F +
Sbjct: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
+ + +V++ +E ++ LF Q+ +L PF EYL S++F RFLQWKWLE QP
Sbjct: 126 LDEGIVAKFKEGPVEIQ-DGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQP 184
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACK+L KKR+KKRKG A+ EK+IL K
Sbjct: 185 MGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMK 244
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCG 298
V+S+F+V+LAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RALFY A+I+CG
Sbjct: 245 VHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICG 304
Query: 299 LEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL-IRGRVGTVGYMAPEVL 357
LE LH+ VYRDLKPEN+LLD+ G++RISDLGLAV++ +G +G GT G+MAPE+L
Sbjct: 305 LEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELL 364
Query: 358 NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAK 417
+ Y S DY+ LG +YEMI + PFR R EKV+ +E+ R++ Y KFS+ +K
Sbjct: 365 QGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASK 424
Query: 418 SICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV 477
C+ LL KD ++RLG ++E +++ HP F+++N+++LEAGML PPF+PD + VY KD+
Sbjct: 425 DFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDI 484
Query: 478 LDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDL 537
D+ FSTVKGV D TD +F+ +F+TG+ IPWQ EMIET F ELNV+ +G +P D+
Sbjct: 485 QDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDDM 544
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 476 bits (1226), Expect = e-134
Identities = 240/527 (45%), Positives = 347/527 (65%), Gaps = 6/527 (1%)
Query: 3 LENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPI 62
L+N++ANT L+AR+ K ++ + L P + C +LR+ + ++ SLC++QPI
Sbjct: 7 LDNLIANTAYLQARKPSDCDSKELQRR-RRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
Query: 63 GRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKE--IMTKYLTPKSPVFIAQ 120
GR LFR F T P FL+ V +E+ + + + + T P
Sbjct: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
Query: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180
+ Q + ++ + ++ + +L+ +PF +++ S F+D+FLQWK E QP
Sbjct: 126 LSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQP 185
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
V+ F ++RVLGKGGFGEVCA QV+ TGKMYACK+L+KKR+KK+ GE MAL EK+ILEK
Sbjct: 186 VSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEK 245
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
V+S F+V+LAYA+E+K LCLV+++MNGGDLKFHIYN+G G + R +FY+A+I CG+
Sbjct: 246 VSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGML 305
Query: 301 DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
LH VYRD+KPEN+LLDD G+ R+SDLGLAV++ G I R GT GYMAPE+L +
Sbjct: 306 HLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEK 365
Query: 361 -RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH-KFSEEAKS 418
Y D++ +GC IYEM+ G++PF+ KEKV +E++ +R L+ E + H F+EEAK
Sbjct: 366 VSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKD 425
Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVL 478
IC++ L K +QRLG +E+ + + ++H FF+ +NF RLEAG+++PPFVPDP VY KD+
Sbjct: 426 ICRLFLAKKPEQRLGSREK-SDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIA 484
Query: 479 DIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELN 525
+I+ FS V+GV D D F+ F+TG+V I WQ E+IET F+ELN
Sbjct: 485 EIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 310 bits (793), Expect = 3e-84
Identities = 186/473 (39%), Positives = 268/473 (56%), Gaps = 23/473 (4%)
Query: 60 QPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYE-VTPDEKLGEKGKEIMTKYLTPK 113
Q +G LLFR FC E RP ++F + + +YE + +E+ + +EI Y+ +
Sbjct: 61 QKLGYLLFRDFCLNHLEEARP----LVEFYEEIKKYEKLETEEERVARSREIFDSYIMKE 116
Query: 114 SPVFIAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQ 172
+ + L +K +LF + + + LRG+ F ++++S F RF Q
Sbjct: 117 LLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQ 176
Query: 173 WKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA 231
WK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE++A
Sbjct: 177 WKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 236
Query: 232 LNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERA 288
LNE+ +L V++ F+V ++YA+ T D L +L +MNGGDL +H+ G F E
Sbjct: 237 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGV--FSEADM 294
Query: 289 LFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGT 348
FYAAEI+ GLE +H VYRDLKP NILLD++GH+RISDLGLA + VGT
Sbjct: 295 RFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGT 353
Query: 349 VGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEV 407
GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L
Sbjct: 354 HGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE 412
Query: 408 YSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
FS E +S+ + LL +D +RLGC GA EVK PFFR+++++ + PP +P
Sbjct: 413 LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472
Query: 468 DPRAVYCKDVLDIEQF--STVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIET 518
V D DI F KG+ L +D + Y F ++S WQ E+ ET
Sbjct: 473 PRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET 524
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 306 bits (783), Expect = 4e-83
Identities = 199/537 (37%), Positives = 285/537 (53%), Gaps = 35/537 (6%)
Query: 2 ELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQ------CEDLRRTIDRDYCS 55
+LE ++A+ L A E ++ K + +L P I E T D+ +
Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASK-RIVLPEPSIRSVMQKYLAERNEITFDKIF-- 59
Query: 56 LCDKQPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYEVTPDEKLGE-KGKEIMTKY 109
Q IG LLF+ FC E P ++F + + EYE +E+ + ++I Y
Sbjct: 60 ---NQKIGFLLFKDFCLNEINEAVP----QVKFYEEIKEYEKLDNEEDRLCRSRQIYDAY 112
Query: 110 LTPKSPVFIAQVGQDLVSQTEEKLLQKPCKE-LFSACAQSVHEYLRGEPFHEYLDSMFFD 168
+ + + V + L +K LF + + E LRG+ F ++++S F
Sbjct: 113 IMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFT 172
Query: 169 RFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG 227
RF QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++G
Sbjct: 173 RFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232
Query: 228 ESMALNEKQILEKVNS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFE 284
E++ALNE+ +L V++ F+V + YA+ T D LC +L +MNGGDL +H+ G F
Sbjct: 233 ETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFS 290
Query: 285 EERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRG 344
E+ FYA EI+ GLE +H VYRDLKP NILLD++GH RISDLGLA +
Sbjct: 291 EKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHA 349
Query: 345 RVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE 403
VGT GYMAPEVL Y S D++ LGC++++++ G SPFR K K K E+DR L
Sbjct: 350 SVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLT 408
Query: 404 TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDP 463
FS E KS+ + LL +D +RLGC G+ EVK H FF+ ++++ + P
Sbjct: 409 VNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPP 468
Query: 464 PFVPDPRAVYCKDVLDIEQF--STVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIET 518
P +P V D DI F KG+ L D + Y F +S WQ E+ ET
Sbjct: 469 PLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 207 bits (528), Expect = 2e-53
Identities = 114/284 (40%), Positives = 169/284 (59%), Gaps = 8/284 (2%)
Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244
F VLGKG FG+V + T ++YA K L+K + + + EK++L ++
Sbjct: 339 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 398
Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304
F+ L ++T D L V+ +NGGDL +HI +G F+E +A+FYAAEI GL LH+
Sbjct: 399 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISIGLFFLHK 456
Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363
+YRDLK +N++LD GHI+I+D G+ + + +G R GT Y+APE++ Q YG
Sbjct: 457 RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYG 516
Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423
S D+W G L+YEM+ GQ PF G E +E+ + ++E Y S+EA SICK L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLSKEAVSICKGL 572
Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
+TK +RLGC EG +V+ H FFR +++++LE + PPF P
Sbjct: 573 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 206 bits (525), Expect = 4e-53
Identities = 120/291 (41%), Positives = 168/291 (57%), Gaps = 7/291 (2%)
Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQI 237
R VT N F ++LGKG FG+V + +ATG+ YA K L K+ I + + + E ++
Sbjct: 144 RAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 203
Query: 238 LEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297
L+ F+ L YA++T D LC V+ NGG+L FH+ F EERA FY AEI+
Sbjct: 204 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVS 261
Query: 298 GLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEV 356
LE LH + VYRD+K EN++LD GHI+I+D GL + I +G ++ GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 357 LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEA 416
L + YG + D+WGLG ++YEM+ G+ PF + E + +L E + S EA
Sbjct: 322 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHERLFELILMEEIRFPRTLSPEA 377
Query: 417 KSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
KS+ LL KD KQRLG A EV H FF ++N++ + L PPF P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 206 bits (525), Expect = 4e-53
Identities = 119/315 (37%), Positives = 180/315 (57%), Gaps = 10/315 (3%)
Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244
F VLGKG FG+V + + T ++YA K L+K + + + EK++L
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304
F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI GL L
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363
+ +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+APE++ Q YG
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519
Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423
S D+W G L+YEM+ GQ+PF G E +E+ + ++E Y S+EA +ICK L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQF 483
+TK +RLGC EG ++K H FFR +++++LE + PP+ P R +D + ++
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDK--RDTSNFDKE 633
Query: 484 STVKGVNLDHTDDDF 498
T + V L TD F
Sbjct: 634 FTRQPVELTPTDKLF 648
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 204 bits (520), Expect = 1e-52
Identities = 118/289 (40%), Positives = 169/289 (58%), Gaps = 8/289 (2%)
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 301 DLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358
LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418
+ YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKS 378
Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
+ LL KD KQRLG E A E+ +H FF + ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 204 bits (520), Expect = 1e-52
Identities = 118/289 (40%), Positives = 169/289 (58%), Gaps = 8/289 (2%)
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 301 DLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358
LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418
+ YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKS 378
Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
+ LL KD KQRLG E A E+ +H FF + ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 204 bits (520), Expect = 1e-52
Identities = 118/289 (40%), Positives = 169/289 (58%), Gaps = 8/289 (2%)
Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240
VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + + L E ++L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300
F+ L Y+++T D LC V+ NGG+L FH+ F E+RA FY AEI+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 301 DLHRE-NTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLN 358
LH E N VYRDLK EN++LD GHI+I+D GL + I +G ++ GT Y+APEVL
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 359 NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKS 418
+ YG + D+WGLG ++YEM+ G+ PF + E++ +L E + EAKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLGPEAKS 378
Query: 419 ICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
+ LL KD KQRLG E A E+ +H FF + ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 204 bits (518), Expect = 2e-52
Identities = 121/289 (41%), Positives = 169/289 (58%), Gaps = 11/289 (3%)
Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS-- 243
FR VLG+G FG+V + + T +M+A K L+K I R + EK+I E VNS
Sbjct: 657 FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 716
Query: 244 -QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302
F+VNL ++TK+ +C V+ GGDL HI+ F E RA+FYAA ++ GL+ L
Sbjct: 717 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLGLQYL 773
Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361
H VYRDLK +N+LLD G ++I+D GL + + GD GT ++APEVL
Sbjct: 774 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 833
Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421
Y + D+WGLG LIYEM+ G+SPF G E EEV ++ E Y S EA SI +
Sbjct: 834 YTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISIMR 889
Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470
LL ++ ++RLG E+ A +VK+HPFFR +++ L + PPF+P R
Sbjct: 890 RLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIR 938
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 204 bits (518), Expect = 2e-52
Identities = 119/296 (40%), Positives = 173/296 (58%), Gaps = 11/296 (3%)
Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235
L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK
Sbjct: 611 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 670
Query: 236 QILEKVNSQ---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292
+IL V S F+VNL ++T + +C V+ GGDL HI++ F E RA+FY+
Sbjct: 671 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 727
Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGY 351
A ++ GL+ LH VYRDLK +N+LLD G+++I+D GL + + GD GT +
Sbjct: 728 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 787
Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411
+APEVL + Y + D+WGLG L+YEM+ G+SPF G E EEV ++ E Y
Sbjct: 788 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 843
Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
S EA I + LL ++ ++RLG E A +VK+ PFFR + ++ L A L PPFVP
Sbjct: 844 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 899
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 204 bits (518), Expect = 2e-52
Identities = 119/296 (40%), Positives = 173/296 (58%), Gaps = 11/296 (3%)
Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEK 235
L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK
Sbjct: 605 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 664
Query: 236 QILEKVNSQ---FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292
+IL V S F+VNL ++T + +C V+ GGDL HI++ F E RA+FY+
Sbjct: 665 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 721
Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGY 351
A ++ GL+ LH VYRDLK +N+LLD G+++I+D GL + + GD GT +
Sbjct: 722 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 781
Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411
+APEVL + Y + D+WGLG L+YEM+ G+SPF G E EEV ++ E Y
Sbjct: 782 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 837
Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
S EA I + LL ++ ++RLG E A +VK+ PFFR + ++ L A L PPFVP
Sbjct: 838 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 893
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 203 bits (516), Expect = 4e-52
Identities = 111/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)
Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ- 244
F VLGKG FG+V + + T ++YA K L+K + + + EK++L
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304
F+ L ++T D L V+ +NGGDL +HI +G F+E A+FYAAEI GL L
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363
+ +YRDLK +N++LD GHI+I+D G+ + I +G + GT Y+APE++ Q YG
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519
Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423
S D+W G L+YEM+ GQ+PF G E +E+ + ++E Y S+EA +ICK L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
+TK +RLGC EG ++K H FFR +++++LE + PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 199 bits (507), Expect = 5e-51
Identities = 112/287 (39%), Positives = 168/287 (58%), Gaps = 7/287 (2%)
Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241
T N F ++LGKG FG+V + +A+GK YA K L+K+ I + + L E ++L+
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301
F+ +L Y+++TKD LC V+ +NGG+L FH+ F E+R FY AEI+ L+
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261
Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQ 360
LH VYRDLK EN++LD GHI+I+D GL + I + ++ GT Y+APEVL +
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
YG + D+WGLG ++YEM+ G+ PF + E++ +L + + S +AKS+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
LL KD +RLG + A E+ RH FF +N++ + L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 199 bits (507), Expect = 5e-51
Identities = 112/287 (39%), Positives = 168/287 (58%), Gaps = 7/287 (2%)
Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV 241
T N F ++LGKG FG+V + +A+GK YA K L+K+ I + + L E ++L+
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301
F+ +L Y+++TKD LC V+ +NGG+L FH+ F E+R FY AEI+ L+
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261
Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQ 360
LH VYRDLK EN++LD GHI+I+D GL + I + ++ GT Y+APEVL +
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
YG + D+WGLG ++YEM+ G+ PF + E++ +L + + S +AKS+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVP 467
LL KD +RLG + A E+ RH FF +N++ + L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 197 bits (502), Expect = 2e-50
Identities = 124/323 (38%), Positives = 178/323 (55%), Gaps = 18/323 (5%)
Query: 186 FRQYRVLGKGGFGEVCACQ-VRAT--GKMYACKRLEKKRI-KKRKGESMALNEKQILEKV 241
F RVLGKGG+G+V + V+ T GK+YA K L K +I + K + E+ ILE V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 242 NSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLED 301
F+V LAYA++T L L+L ++GG+L H+ G F E+ A FY AEI L
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI--FLEDTACFYLAEITLALGH 184
Query: 302 LHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQ 360
LH + +YRDLKPENI+L GHI+++D GL + I EG + GT+ YMAPE+L
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRS 244
Query: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420
+ + D+W LG L+Y+M+ G PF K +++ R L + +A+ +
Sbjct: 245 GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPY----LTPDARDLV 300
Query: 421 KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480
K L ++ QR+G AA+V+RHPFFR+MN+ L A +DPPF P + D+
Sbjct: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP-----CLQSEEDV 355
Query: 481 EQFST--VKGVNLDHTDDDFYSK 501
QF T + +D DD S+
Sbjct: 356 SQFDTRFTRQTPVDSPDDTALSE 378
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 195 bits (496), Expect = 9e-50
Identities = 121/332 (36%), Positives = 187/332 (56%), Gaps = 22/332 (6%)
Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRA-----TGKMYACKRLEKKRI-KKRKGESMAL 232
+ + F RVLGKGG+G+V QVR TGK++A K L+K I + K +
Sbjct: 84 EKIRPECFELLRVLGKGGYGKVF--QVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTK 141
Query: 233 NEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYA 292
E+ ILE+V F+V+L YA++T L L+L ++GG+L + G F E+ A FY
Sbjct: 142 AERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI--FMEDTACFYL 199
Query: 293 AEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGY 351
AEI L LH++ +YRDLKPENI+L+ GH++++D GL + I +G + GT+ Y
Sbjct: 200 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 259
Query: 352 MAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHK 411
MAPE+L + + D+W LG L+Y+M+ G PF G K + +D ++L+ +
Sbjct: 260 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRK---KTID-KILKCKLNLPPY 315
Query: 412 FSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRA 471
++EA+ + K LL ++A RLG A EV+ HPFFR++N++ L A ++PPF P
Sbjct: 316 LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP---- 371
Query: 472 VYCKDVLDIEQFST--VKGVNLDHTDDDFYSK 501
+ D+ QF + + +D DD S+
Sbjct: 372 -LLQSEEDVSQFDSKFTRQTPVDSPDDSTLSE 402
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 195 bits (495), Expect = 1e-49
Identities = 113/286 (39%), Positives = 160/286 (55%), Gaps = 13/286 (4%)
Query: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNS------Q 244
VLGKG FG+V + R + ++YA K L+K I + L EK++L
Sbjct: 356 VLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPH 415
Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304
F+ L ++T D L V+ + GGDL +HI +G F+E A FYAAEI GL LH
Sbjct: 416 FLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGK--FKEPHAAFYAAEIAIGLFFLHN 473
Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363
+ +YRDLK +N++LD GHI+I+D G+ + + G R GT Y+APE++ Q YG
Sbjct: 474 QGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYG 533
Query: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKML 423
S D+W G L+YEM+ GQ PF G E EE+ + ++E Y S EA +ICK
Sbjct: 534 KSVDWWSFGVLLYEMLAGQPPFDGEDE----EELFQAIMEQTVTYPKSLSREAVAICKGF 589
Query: 424 LTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDP 469
LTK +RLG +G ++ H FFR ++++RLE + PPF P P
Sbjct: 590 LTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRP 635
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 193 bits (490), Expect = 4e-49
Identities = 116/324 (35%), Positives = 177/324 (54%), Gaps = 12/324 (3%)
Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-NSQ 244
F RV+G+G + +V +++ T ++YA K ++K+ + + EK + E+ N
Sbjct: 254 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 313
Query: 245 FVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHR 304
F+V L ++T+ L V+ +NGGDL FH+ EE A FY+AEI L LH
Sbjct: 314 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLALNYLHE 371
Query: 305 ENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQRYG 363
+YRDLK +N+LLD GHI+++D G+ + + GD GT Y+APE+L + YG
Sbjct: 372 RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYG 431
Query: 364 LSPDYWGLGCLIYEMIEGQSPFR--GRKEKVKREEVD---RRVLETEEVYSHKFSEEAKS 418
S D+W LG L++EM+ G+SPF G + + D + +LE + S +A S
Sbjct: 432 FSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS 491
Query: 419 ICKMLLTKDAKQRLGCQ-EEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDV 477
+ K L KD K+RLGC + G A+++ HPFFRN+++ +E + PPF P+ + D
Sbjct: 492 VLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDN 551
Query: 478 LDIEQFSTVKGVNLDHTDDDFYSK 501
D QF T + V L DDD K
Sbjct: 552 FD-SQF-TNEPVQLTPDDDDIVRK 573
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 192 bits (487), Expect = 9e-49
Identities = 110/287 (38%), Positives = 159/287 (55%), Gaps = 9/287 (3%)
Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N 242
+ F RVLGKG FG+V +V+ TG +YA K L+K I + + EK+IL N
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302
F+ L ++T D L V+ +NGGDL FHI F+E RA FYAAEI+ L L
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR--FDEARARFYAAEIISALMFL 470
Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVK-IPEGDLIRGRVGTVGYMAPEVLNNQR 361
H + +YRDLK +N+LLD GH +++D G+ + I G GT Y+APE+L
Sbjct: 471 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 530
Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421
YG + D+W +G L+YEM+ G +PF E +++ +L E VY E+A I K
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILK 586
Query: 422 MLLTKDAKQRLGCQEEGAAE-VKRHPFFRNMNFKRLEAGMLDPPFVP 467
+TK+ RLG +G + RHPFF+ +++ +L ++PPF P
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 191 bits (486), Expect = 1e-48
Identities = 113/314 (35%), Positives = 175/314 (55%), Gaps = 14/314 (4%)
Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE-KVN 242
N F ++VLGKG FG+V +++ G+ +A K L+K + + EK++L
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302
+ F+ +L ++TKD L V+ +NGGDL +HI + G FE RA FYAAEI+CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464
Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-VGTVGYMAPEVLNNQR 361
H + +YRDLK +N+LLD GHI+I+D G+ + G+ GT Y+APE+L +
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421
Y S D+W G L+YEM+ GQSPF G E +E+ + Y ++E+K I +
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481
L ++ +RLG +K HPFF+ +N+ LE L+PPF P ++ +D + +
Sbjct: 581 KLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSP--RDYSNFD 634
Query: 482 QFSTVKGVNLDHTD 495
Q + L ++D
Sbjct: 635 QEFLNEKARLSYSD 648
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 191 bits (486), Expect = 1e-48
Identities = 113/314 (35%), Positives = 175/314 (55%), Gaps = 14/314 (4%)
Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE-KVN 242
N F ++VLGKG FG+V +++ G+ +A K L+K + + EK++L
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
Query: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302
+ F+ +L ++TKD L V+ +NGGDL +HI + G FE RA FYAAEI+CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464
Query: 303 HRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGR-VGTVGYMAPEVLNNQR 361
H + +YRDLK +N+LLD GHI+I+D G+ + G+ GT Y+APE+L +
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICK 421
Y S D+W G L+YEM+ GQSPF G E +E+ + Y ++E+K I +
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 422 MLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIE 481
L ++ +RLG +K HPFF+ +N+ LE L+PPF P ++ +D + +
Sbjct: 581 KLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSP--RDYSNFD 634
Query: 482 QFSTVKGVNLDHTD 495
Q + L ++D
Sbjct: 635 QEFLNEKARLSYSD 648
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,729,330
Number of Sequences: 37866
Number of extensions: 1194507
Number of successful extensions: 5394
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 3203
Number of HSP's gapped (non-prelim): 960
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.