Guide to the Human Genome
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Search of human proteins with 48762679

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48762679 growth factor receptor-bound protein 10 isoform a
[Homo sapiens]
         (594 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48762679 growth factor receptor-bound protein 10 isoform a [H...  1216   0.0  
gi|48762693 growth factor receptor-bound protein 10 isoform b [H...  1098   0.0  
gi|48762697 growth factor receptor-bound protein 10 isoform c [H...  1095   0.0  
gi|48762695 growth factor receptor-bound protein 10 isoform c [H...  1095   0.0  
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]    573   e-163
gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]     550   e-156
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]     550   e-156
gi|56118221 amyloid beta (A4) precursor protein-binding, family ...   160   3e-39
gi|47132519 Ras association and pleckstrin homology domains 1 is...   152   8e-37
gi|42740893 Ras association and pleckstrin homology domains 1 is...   152   8e-37
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           60   7e-09
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            60   7e-09
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1...    52   2e-06
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ...    52   2e-06
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ...    52   2e-06
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]               50   6e-06
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 50   6e-06
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap...    48   2e-05
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]          48   3e-05
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]          48   3e-05
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...    48   3e-05
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...    48   3e-05
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...    48   3e-05
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [...    47   4e-05
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        46   8e-05
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...    46   1e-04
gi|169790811 SHC (Src homology 2 domain containing) transforming...    46   1e-04
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      45   1e-04
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]      45   2e-04
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]             45   2e-04

>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
           sapiens]
          Length = 594

 Score = 1216 bits (3146), Expect = 0.0
 Identities = 594/594 (100%), Positives = 594/594 (100%)

Query: 1   MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60
           MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN
Sbjct: 1   MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60

Query: 61  ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120
           ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV
Sbjct: 61  ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120

Query: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180
           RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
Sbjct: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180

Query: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240
           VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE
Sbjct: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240

Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300
           SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK
Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300

Query: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360
           ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
Sbjct: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360

Query: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420
           GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF
Sbjct: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420

Query: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480
           STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP
Sbjct: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480

Query: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540
           STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK
Sbjct: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540

Query: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
           NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594


>gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo
           sapiens]
          Length = 548

 Score = 1098 bits (2840), Expect = 0.0
 Identities = 548/594 (92%), Positives = 548/594 (92%), Gaps = 46/594 (7%)

Query: 1   MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60
           MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN
Sbjct: 1   MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60

Query: 61  ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120
           ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV
Sbjct: 61  ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120

Query: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180
           RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
Sbjct: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180

Query: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240
           VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE
Sbjct: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240

Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300
           SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQ                  
Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQ------------------ 282

Query: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360
                                       EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
Sbjct: 283 ----------------------------EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 314

Query: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420
           GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF
Sbjct: 315 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 374

Query: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480
           STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP
Sbjct: 375 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 434

Query: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540
           STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK
Sbjct: 435 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 494

Query: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
           NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 495 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 548


>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score = 1095 bits (2831), Expect = 0.0
 Identities = 536/536 (100%), Positives = 536/536 (100%)

Query: 59  MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 118
           MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL
Sbjct: 1   MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 60

Query: 119 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 178
           AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT
Sbjct: 61  AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 120

Query: 179 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 238
           SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA
Sbjct: 121 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 180

Query: 239 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 298
           SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH
Sbjct: 181 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 240

Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
           VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT
Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300

Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418
           DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS
Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 360

Query: 419 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 478
           PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL
Sbjct: 361 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 420

Query: 479 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 538
           HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK
Sbjct: 421 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 480

Query: 539 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
           IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 481 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536


>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score = 1095 bits (2831), Expect = 0.0
 Identities = 536/536 (100%), Positives = 536/536 (100%)

Query: 59  MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 118
           MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL
Sbjct: 1   MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 60

Query: 119 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 178
           AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT
Sbjct: 61  AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 120

Query: 179 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 238
           SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA
Sbjct: 121 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 180

Query: 239 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 298
           SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH
Sbjct: 181 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 240

Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
           VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT
Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300

Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418
           DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS
Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 360

Query: 419 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 478
           PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL
Sbjct: 361 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 420

Query: 479 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 538
           HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK
Sbjct: 421 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 480

Query: 539 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
           IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 481 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536


>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
          Length = 540

 Score =  573 bits (1477), Expect = e-163
 Identities = 297/539 (55%), Positives = 385/539 (71%), Gaps = 27/539 (5%)

Query: 80  LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 122
           LQ+GQ A S+  A   P + Q                 P +  R  +         A  R
Sbjct: 5   LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64

Query: 123 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 182
            +++D       +P+IPNPFPELC      VL+    P + +  KQ +KV+SED TS+ +
Sbjct: 65  RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122

Query: 183 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 240
           ++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S   +  E
Sbjct: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182

Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLH 298
           +K  FRKNYAKYEFFKNPM FFPE MV++  ++NG  S TQ+LQ FL+SS+ PEI GFLH
Sbjct: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242

Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
            KE GKKSWKK+Y  LRRSGLY STKGTSKEPRHLQ  ++  +S+I+  +AG+K++ APT
Sbjct: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302

Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 417
           ++G C KPNK     ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY  P Q R    
Sbjct: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361

Query: 418 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 476
           S   +P+RS+SENSLVAMDFSGQ  RVIENP EA S A+EEG AWRK+   R+   GS +
Sbjct: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421

Query: 477 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 535
               S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H
Sbjct: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481

Query: 536 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
            QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL
Sbjct: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540


>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score =  550 bits (1418), Expect = e-156
 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)

Query: 90  PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147
           P    PP + +P  +P  + V+RSQP+ I    R+L+EE++  R +SLP+IPNPFPELC 
Sbjct: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76

Query: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202
           P S   +  G      L P  A+    VKV+SEDG  + VE+ A  TAR +C++LV ++H
Sbjct: 77  PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136

Query: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259
            + D +W LVE HPHL LER LEDHE VV+V++   +  +S+F+FRKN+AKYE FK+ P 
Sbjct: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196

Query: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317
           + FPE+MV+ C  ++   S   L+QNFLN+ S PEIQGFL ++  G+K WK+ +  LRRS
Sbjct: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256

Query: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377
           GLY STKGTSK+PRHLQ +AD+ +SN++ +  GRK Y  PTD G C+KPNK+RN  K LR
Sbjct: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316

Query: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436
           + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+  Q R    S   S P+RS S+N+LVAMD
Sbjct: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376

Query: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496
           FSG  GRVIENP EA S ALEE  AWRK++     L    P   ++LS  IHRTQ WFHG
Sbjct: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434

Query: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556
           RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494

Query: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
           +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532


>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score =  550 bits (1418), Expect = e-156
 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)

Query: 90  PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147
           P    PP + +P  +P  + V+RSQP+ I    R+L+EE++  R +SLP+IPNPFPELC 
Sbjct: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76

Query: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202
           P S   +  G      L P  A+    VKV+SEDG  + VE+ A  TAR +C++LV ++H
Sbjct: 77  PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136

Query: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259
            + D +W LVE HPHL LER LEDHE VV+V++   +  +S+F+FRKN+AKYE FK+ P 
Sbjct: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196

Query: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317
           + FPE+MV+ C  ++   S   L+QNFLN+ S PEIQGFL ++  G+K WK+ +  LRRS
Sbjct: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256

Query: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377
           GLY STKGTSK+PRHLQ +AD+ +SN++ +  GRK Y  PTD G C+KPNK+RN  K LR
Sbjct: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316

Query: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436
           + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+  Q R    S   S P+RS S+N+LVAMD
Sbjct: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376

Query: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496
           FSG  GRVIENP EA S ALEE  AWRK++     L    P   ++LS  IHRTQ WFHG
Sbjct: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434

Query: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556
           RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494

Query: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
           +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532


>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
           member 1 interacting protein [Homo sapiens]
          Length = 666

 Score =  160 bits (405), Expect = 3e-39
 Identities = 123/400 (30%), Positives = 185/400 (46%), Gaps = 50/400 (12%)

Query: 48  DDVDLEALVNDMNASL-ESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPR 106
           +D DL+AL+ D+ A + E+       Q ++   LQN  H+ S          +Q  +   
Sbjct: 60  EDQDLDALMADLVADISEAEQRTIQAQKES---LQNQHHSAS----------LQASIFSG 106

Query: 107 QRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAA 166
                    ++ A    Q ED      + P +  P P       PP   P S    +A A
Sbjct: 107 A-ASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLP-------PPPPEPLSQEEEEAQA 158

Query: 167 KQD------------------VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNS 208
           K D                  VKV   D ++K + +     ARD+   L  K+HC  +  
Sbjct: 159 KADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVD 218

Query: 209 WTLVEHHPHLGLERCLEDHELVVQVES--TMASESKFLFRKNYAKYEFFKNPMNFF---- 262
           W L E +P L +ER  EDHE VV+V S  T  +E+K LF +   KY  FKNP NF+    
Sbjct: 219 WCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNR 278

Query: 263 --PEQMVTWCQQSNGSQTQLLQNFLNSSSC--PEIQGFLHVKELGKKSWKKLYVCLRRSG 318
              E   T  + +  ++  LL+     +S   PE++G L++KE GKKSWK+ Y  LR SG
Sbjct: 279 GKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASG 338

Query: 319 LYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELRL 378
           +Y   KG +K  R L      E+ NI+     + +Y APTD+   +K  +++ E++ ++ 
Sbjct: 339 IYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKY 398

Query: 379 LCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418
           LC +D +T   W+   R+ KYG  LY NY+    +  L S
Sbjct: 399 LCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLAS 438


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score =  152 bits (384), Expect = 8e-37
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 273 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 332

Query: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 333 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 392

Query: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 393 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 452

Query: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 453 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 512

Query: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 513 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 564


>gi|42740893 Ras association and pleckstrin homology domains 1
           isoform 3 [Homo sapiens]
          Length = 644

 Score =  152 bits (384), Expect = 8e-37
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384

Query: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 444

Query: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 445 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 504

Query: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564

Query: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 5/101 (4%)

Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
           SQ P     ++T  H    WFHG+ISREES +I+      +G FL+R ++ N  ++ L L
Sbjct: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCL 207

Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 574
            H  K+ +++I   + D     S+ +G  KF  L QLV+ Y
Sbjct: 208 LHEGKVLHYRI---DKDKTGKLSIPEGK-KFDTLWQLVEHY 244



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 4/94 (4%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           +F G I+REE+   + Q G+ DGL+LLR S++    F L++ H +K  ++ I   E +  
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLK 586
             +++  G T  S    L  ++      L C LK
Sbjct: 72  GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 5/101 (4%)

Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
           SQ P     ++T  H    WFHG+ISREES +I+      +G FL+R ++ N  ++ L L
Sbjct: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCL 207

Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 574
            H  K+ +++I   + D     S+ +G  KF  L QLV+ Y
Sbjct: 208 LHEGKVLHYRI---DKDKTGKLSIPEGK-KFDTLWQLVEHY 244



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 4/94 (4%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           +F G I+REE+   + Q G+ DGL+LLR S++    F L++ H +K  ++ I   E +  
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLK 586
             +++  G T  S    L  ++      L C LK
Sbjct: 72  GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104


>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
           [Homo sapiens]
          Length = 619

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 4/99 (4%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           +F+G ISR E+   +K  G+ DGLFLLR    +   +VL+L H  +  +F   P E    
Sbjct: 10  FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 591
             +++  G        +L +FY  +   LPC L+  C R
Sbjct: 67  GTYAIAGGKAHCGP-AELCEFYSRDPDGLPCNLRKPCNR 104



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/116 (29%), Positives = 56/116 (48%), Gaps = 5/116 (4%)

Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
           SQ+P     ++T  H    W+H  ++REE+ R +      DG FLLR  +     + L+L
Sbjct: 144 SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSL 202

Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHC 589
            + + + ++ I     D    + + +G TKF  L QLV++ +L    L   LK  C
Sbjct: 203 IYGKTVYHYLI---SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254


>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
           sapiens]
          Length = 1188

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 28/84 (33%), Positives = 51/84 (60%), Gaps = 2/84 (2%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           W HG I+R ++  ++ + G  DG FL+R S+S  +A+ L + +   +  ++ILP EDD  
Sbjct: 5   WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKF 63

Query: 553 TFFSLDDGNTK-FSDLIQLVDFYQ 575
           T  + +  + + F+ L QL++FY+
Sbjct: 64  TVQASEGVSMRFFTKLDQLIEFYK 87


>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
           sapiens]
          Length = 1189

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 28/84 (33%), Positives = 51/84 (60%), Gaps = 2/84 (2%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           W HG I+R ++  ++ + G  DG FL+R S+S  +A+ L + +   +  ++ILP EDD  
Sbjct: 5   WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKF 63

Query: 553 TFFSLDDGNTK-FSDLIQLVDFYQ 575
           T  + +  + + F+ L QL++FY+
Sbjct: 64  TVQASEGVSMRFFTKLDQLIEFYK 87


>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
          Length = 330

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 9/106 (8%)

Query: 472 LGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVL 531
           LGSQ    P     +  +   WFH  +SR ++  ++   G   G F++R SQS+P  F +
Sbjct: 39  LGSQEGYVPKNFIDI--QFPKWFHEGLSRHQAENLL--MGKEVGFFIIRASQSSPGDFSI 94

Query: 532 TLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577
           ++ H   +++F+++   D+   +F   +   KF  L +LVD+Y+ N
Sbjct: 95  SVRHEDDVQHFKVM--RDNKGNYFLWTE---KFPSLNKLVDYYRTN 135


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 28/83 (33%), Positives = 53/83 (63%), Gaps = 6/83 (7%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           W+ GRISR+ +  I+ ++  + G FL+R+S+S+P  F +++ +  ++++F++L  E  G+
Sbjct: 60  WYSGRISRQLAEEILMKRNHL-GAFLIRESESSPGEFSVSVNYGDQVQHFKVLR-EASGK 117

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQ 575
            F        KF+ L +LVDFY+
Sbjct: 118 YFL----WEEKFNSLNELVDFYR 136


>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo
           sapiens]
          Length = 1258

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 23/115 (20%)

Query: 472 LGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVL 531
           LGSQ+P               W+H  +SR  +  ++ + G  DG FL+RDS+S   AF L
Sbjct: 14  LGSQAP--------------SWYHRDLSRAAAEELLARAGR-DGSFLVRDSESVAGAFAL 58

Query: 532 TLCHHQKIKNFQILPCEDDGQTFFSLDDGN----TKFSDLIQLVDFY-QLNKGVL 581
            + + + +  ++ILP   DG+ F ++         +F  L +L+  Y Q N+G++
Sbjct: 59  CVLYQKHVHTYRILP---DGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLV 110


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%)

Query: 484 STVIHRTQHWFHGRISREESHRIIKQQ---------GLVDGLFLLRDSQSNPKAFVLTLC 534
           ST +H  + WFHG++      R I ++         G  DG FL+R+S++    + L+  
Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600

Query: 535 HHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575
            + K+++ +I   +D G   F L D N  F  L  L+  YQ
Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTD-NLVFDSLYDLITHYQ 640



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 8/103 (7%)

Query: 485 TVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544
           T  H ++ W+H  ++R ++  ++ +    DG FL+R  ++ P ++ ++     KIK+ ++
Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVR-KRNEPNSYAISFRAEGKIKHCRV 717

Query: 545 LPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587
              + +GQT      GN++F  L+ L+ +Y+ +      KL++
Sbjct: 718 ---QQEGQTVML---GNSEFDSLVDLISYYEKHPLYRKMKLRY 754


>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
          Length = 1290

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%)

Query: 484 STVIHRTQHWFHGRISREESHRIIKQQ---------GLVDGLFLLRDSQSNPKAFVLTLC 534
           ST +H  + WFHG++      R I ++         G  DG FL+R+S++    + L+  
Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600

Query: 535 HHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575
            + K+++ +I   +D G   F L D N  F  L  L+  YQ
Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTD-NLVFDSLYDLITHYQ 640



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 8/103 (7%)

Query: 485 TVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544
           T  H ++ W+H  ++R ++  ++ +    DG FL+R  ++ P ++ ++     KIK+ ++
Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVR-KRNEPNSYAISFRAEGKIKHCRV 717

Query: 545 LPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587
              + +GQT      GN++F  L+ L+ +Y+ +      KL++
Sbjct: 718 ---QQEGQTVML---GNSEFDSLVDLISYYEKHPLYRKMKLRY 754


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           WFHG+IS +E+  + + Q   DGLFL+R+S  +P  +VL +   + + ++++L    DG 
Sbjct: 81  WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 136

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585
              ++D+    F +L+ +V+ Y  +KG +  KL
Sbjct: 137 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 166


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           WFHG+IS +E+  + + Q   DGLFL+R+S  +P  +VL +   + + ++++L    DG 
Sbjct: 123 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 178

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585
              ++D+    F +L+ +V+ Y  +KG +  KL
Sbjct: 179 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 208


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           WFHG+IS +E+  + + Q   DGLFL+R+S  +P  +VL +   + + ++++L    DG 
Sbjct: 122 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 177

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585
              ++D+    F +L+ +V+ Y  +KG +  KL
Sbjct: 178 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 207


>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
           [Homo sapiens]
          Length = 593

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 6/92 (6%)

Query: 490 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCED 549
           ++ WFH  I+  E+  ++  +G VDG FL R S+SNP  F L++  +  + + +I    D
Sbjct: 3   SRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGD 61

Query: 550 DGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVL 581
               ++ L  G  KF+ L +LV +Y  + G L
Sbjct: 62  ----YYDL-YGGEKFATLAELVQYYMEHHGQL 88



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 18/44 (40%), Positives = 33/44 (75%), Gaps = 1/44 (2%)

Query: 490 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
           ++ WFHG +S +E+ +++ ++G   G FL+R+SQS+P  FVL++
Sbjct: 109 SERWFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSV 151


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 26/83 (31%), Positives = 51/83 (61%), Gaps = 7/83 (8%)

Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
           W++G+++R ++   + ++G  +G FL+RDS+S+P  F ++L    K K+F++   E    
Sbjct: 282 WYYGKVTRHQAEMALNERGH-EGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKE---- 336

Query: 553 TFFSLDDGNTKFSDLIQLVDFYQ 575
           T + +  G  KFS + +LV+ Y+
Sbjct: 337 TVYCI--GQRKFSTMEELVEHYK 357


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 10/89 (11%)

Query: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548
           R + W+HGR+SR  + R+++     DG FL+RDS +NP  +VLT  H  + K+  ++  E
Sbjct: 376 RQEPWYHGRMSRRAAERMLR----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 431

Query: 549 DDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577
              +T       +  F  +  L+D +  N
Sbjct: 432 GVVRT------KDVLFESISHLIDHHLQN 454


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 10/89 (11%)

Query: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548
           R + W+HGR+SR  + R+++     DG FL+RDS +NP  +VLT  H  + K+  ++  E
Sbjct: 483 RQEPWYHGRMSRRAAERMLR----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 538

Query: 549 DDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577
              +T       +  F  +  L+D +  N
Sbjct: 539 GVVRT------KDVLFESISHLIDHHLQN 561


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 51/200 (25%), Positives = 92/200 (46%), Gaps = 26/200 (13%)

Query: 401 MLLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGR----VIENPAEAQSA-A 455
           +LL Q   + + ++++     T  +  ++  L+        G+    V+    +A+S  +
Sbjct: 352 LLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTS 411

Query: 456 LEEGHAWRK-RSTRMNILG----SQSPLHPSTLSTVIHRT------QHWFHGRISREESH 504
           +E      K  S R +I G     +S L  S LS +I  +      Q W+HG I R E+ 
Sbjct: 412 MERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQ 471

Query: 505 RIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKF 564
            ++K+Q    G FL+R+S   P  +VL++    + ++F I+   D+   F       T F
Sbjct: 472 ELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHF-IIQYVDNMYRF-----EGTGF 521

Query: 565 SDLIQLVDFYQLNKGVLPCK 584
           S++ QL+D +   K V+  K
Sbjct: 522 SNIPQLIDHHYTTKQVITKK 541


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 12/145 (8%)

Query: 452 QSAALEE-GHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQ 510
           Q   LEE G  W+ RS      G     + + + ++   T+ WF   ISR+++ R +   
Sbjct: 104 QMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSL--ETEEWFFKGISRKDAERQLLAP 161

Query: 511 GLVDGLFLLRDSQSNPKAFVLTLCHH-----QKIKNFQILPCEDDGQTFFSLDDGNTKFS 565
           G + G F++RDS++   ++ L++  +       +K+++I   ++ G   F +   +T FS
Sbjct: 162 GNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG---FYISPRST-FS 217

Query: 566 DLIQLVDFYQLNKGVLPCKLKHHCI 590
            L +LVD Y+     L  KL   C+
Sbjct: 218 TLQELVDHYKKGNDGLCQKLSVPCM 242


>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/166 (24%), Positives = 77/166 (46%), Gaps = 23/166 (13%)

Query: 423 PVRSVSENSLVAMDFS-GQTGRVIENPA---EAQSAALEEGHAWRKRSTRMNILGSQSPL 478
           P  SV+E  L   +F  G+T  VIE P    E        G         + +L     L
Sbjct: 205 PFSSVTEEEL---NFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPAL 261

Query: 479 HPSTLSTVIHRT---------QHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAF 529
           HP+    + +           + W++G ++R ++   + ++G V+G FL+RDS+S+P  F
Sbjct: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320

Query: 530 VLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575
            ++L    K K+F++   ++     + +  G  +F  + +LV+ Y+
Sbjct: 321 SVSLKASGKNKHFKVQLVDN----VYCI--GQRRFHTMDELVEHYK 360


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,941,421
Number of Sequences: 37866
Number of extensions: 1185178
Number of successful extensions: 5112
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 4851
Number of HSP's gapped (non-prelim): 337
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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