BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo sapiens] (594 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|48762679 growth factor receptor-bound protein 10 isoform a [H... 1216 0.0 gi|48762693 growth factor receptor-bound protein 10 isoform b [H... 1098 0.0 gi|48762697 growth factor receptor-bound protein 10 isoform c [H... 1095 0.0 gi|48762695 growth factor receptor-bound protein 10 isoform c [H... 1095 0.0 gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens] 573 e-163 gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens] 550 e-156 gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens] 550 e-156 gi|56118221 amyloid beta (A4) precursor protein-binding, family ... 160 3e-39 gi|47132519 Ras association and pleckstrin homology domains 1 is... 152 8e-37 gi|42740893 Ras association and pleckstrin homology domains 1 is... 152 8e-37 gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 60 7e-09 gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 60 7e-09 gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 52 2e-06 gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 52 2e-06 gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 52 2e-06 gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 50 6e-06 gi|5729856 GRB2-related adaptor protein [Homo sapiens] 50 6e-06 gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 48 2e-05 gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 48 3e-05 gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 48 3e-05 gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 48 3e-05 gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 48 3e-05 gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 48 3e-05 gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 47 4e-05 gi|5453754 NCK adaptor protein 1 [Homo sapiens] 46 8e-05 gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 46 1e-04 gi|169790811 SHC (Src homology 2 domain containing) transforming... 46 1e-04 gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 45 1e-04 gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 45 2e-04 gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 45 2e-04 >gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo sapiens] Length = 594 Score = 1216 bits (3146), Expect = 0.0 Identities = 594/594 (100%), Positives = 594/594 (100%) Query: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN Sbjct: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60 Query: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV Sbjct: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120 Query: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK Sbjct: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180 Query: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE Sbjct: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240 Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300 Query: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH Sbjct: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360 Query: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF Sbjct: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420 Query: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP Sbjct: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480 Query: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK Sbjct: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540 Query: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL Sbjct: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 >gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo sapiens] Length = 548 Score = 1098 bits (2840), Expect = 0.0 Identities = 548/594 (92%), Positives = 548/594 (92%), Gaps = 46/594 (7%) Query: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN Sbjct: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60 Query: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV Sbjct: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120 Query: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK Sbjct: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180 Query: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE Sbjct: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240 Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQ Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQ------------------ 282 Query: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360 EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH Sbjct: 283 ----------------------------EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 314 Query: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF Sbjct: 315 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 374 Query: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP Sbjct: 375 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 434 Query: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK Sbjct: 435 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 494 Query: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL Sbjct: 495 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 548 >gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo sapiens] Length = 536 Score = 1095 bits (2831), Expect = 0.0 Identities = 536/536 (100%), Positives = 536/536 (100%) Query: 59 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 118 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL Sbjct: 1 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 60 Query: 119 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 178 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT Sbjct: 61 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 120 Query: 179 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 238 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA Sbjct: 121 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 180 Query: 239 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 298 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH Sbjct: 181 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 240 Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300 Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 360 Query: 419 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 478 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL Sbjct: 361 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 420 Query: 479 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 538 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK Sbjct: 421 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 480 Query: 539 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL Sbjct: 481 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536 >gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo sapiens] Length = 536 Score = 1095 bits (2831), Expect = 0.0 Identities = 536/536 (100%), Positives = 536/536 (100%) Query: 59 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 118 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL Sbjct: 1 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 60 Query: 119 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 178 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT Sbjct: 61 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 120 Query: 179 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 238 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA Sbjct: 121 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 180 Query: 239 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 298 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH Sbjct: 181 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 240 Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300 Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 360 Query: 419 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 478 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL Sbjct: 361 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 420 Query: 479 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 538 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK Sbjct: 421 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 480 Query: 539 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL Sbjct: 481 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536 >gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens] Length = 540 Score = 573 bits (1477), Expect = e-163 Identities = 297/539 (55%), Positives = 385/539 (71%), Gaps = 27/539 (5%) Query: 80 LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 122 LQ+GQ A S+ A P + Q P + R + A R Sbjct: 5 LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64 Query: 123 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 182 +++D +P+IPNPFPELC VL+ P + + KQ +KV+SED TS+ + Sbjct: 65 RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122 Query: 183 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 240 ++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S + E Sbjct: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182 Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLH 298 +K FRKNYAKYEFFKNPM FFPE MV++ ++NG S TQ+LQ FL+SS+ PEI GFLH Sbjct: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242 Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358 KE GKKSWKK+Y LRRSGLY STKGTSKEPRHLQ ++ +S+I+ +AG+K++ APT Sbjct: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302 Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 417 ++G C KPNK ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY P Q R Sbjct: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361 Query: 418 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 476 S +P+RS+SENSLVAMDFSGQ RVIENP EA S A+EEG AWRK+ R+ GS + Sbjct: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421 Query: 477 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 535 S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H Sbjct: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481 Query: 536 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL Sbjct: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540 >gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens] Length = 532 Score = 550 bits (1418), Expect = e-156 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%) Query: 90 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147 P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC Sbjct: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76 Query: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202 P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H Sbjct: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136 Query: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259 + D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P Sbjct: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196 Query: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317 + FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS Sbjct: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256 Query: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377 GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR Sbjct: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316 Query: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436 + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD Sbjct: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376 Query: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496 FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG Sbjct: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434 Query: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556 RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS Sbjct: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494 Query: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL Sbjct: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532 >gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens] Length = 532 Score = 550 bits (1418), Expect = e-156 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%) Query: 90 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147 P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC Sbjct: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76 Query: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202 P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H Sbjct: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136 Query: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259 + D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P Sbjct: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196 Query: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317 + FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS Sbjct: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256 Query: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377 GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR Sbjct: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316 Query: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436 + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD Sbjct: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376 Query: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496 FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG Sbjct: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434 Query: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556 RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS Sbjct: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494 Query: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594 +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL Sbjct: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532 >gi|56118221 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein [Homo sapiens] Length = 666 Score = 160 bits (405), Expect = 3e-39 Identities = 123/400 (30%), Positives = 185/400 (46%), Gaps = 50/400 (12%) Query: 48 DDVDLEALVNDMNASL-ESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPR 106 +D DL+AL+ D+ A + E+ Q ++ LQN H+ S +Q + Sbjct: 60 EDQDLDALMADLVADISEAEQRTIQAQKES---LQNQHHSAS----------LQASIFSG 106 Query: 107 QRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAA 166 ++ A Q ED + P + P P PP P S +A A Sbjct: 107 A-ASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLP-------PPPPEPLSQEEEEAQA 158 Query: 167 KQD------------------VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNS 208 K D VKV D ++K + + ARD+ L K+HC + Sbjct: 159 KADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVD 218 Query: 209 WTLVEHHPHLGLERCLEDHELVVQVES--TMASESKFLFRKNYAKYEFFKNPMNFF---- 262 W L E +P L +ER EDHE VV+V S T +E+K LF + KY FKNP NF+ Sbjct: 219 WCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNR 278 Query: 263 --PEQMVTWCQQSNGSQTQLLQNFLNSSSC--PEIQGFLHVKELGKKSWKKLYVCLRRSG 318 E T + + ++ LL+ +S PE++G L++KE GKKSWK+ Y LR SG Sbjct: 279 GKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASG 338 Query: 319 LYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELRL 378 +Y KG +K R L E+ NI+ + +Y APTD+ +K +++ E++ ++ Sbjct: 339 IYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKY 398 Query: 379 LCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418 LC +D +T W+ R+ KYG LY NY+ + L S Sbjct: 399 LCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLAS 438 >gi|47132519 Ras association and pleckstrin homology domains 1 isoform 1 [Homo sapiens] Length = 1250 Score = 152 bits (384), Expect = 8e-37 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%) Query: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229 ++V D +SK + + T R + L+ KSHC W+LVE L +ER EDHE Sbjct: 273 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 332 Query: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287 +V+ + T S++K +F + KY FKNP N+ + T + L + F S Sbjct: 333 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 392 Query: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346 S + PEI+G L +K+ GKKSWKK Y LR SG+Y KG +K R L L+ N++ Sbjct: 393 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 452 Query: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406 R +Y APTD+ L +K +++ +++ ++ LC +D +T W+ R+ KYG LY N Sbjct: 453 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 512 Query: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454 Y+ +R S S+ ++S S +S + S + + ++ Q A Sbjct: 513 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 564 >gi|42740893 Ras association and pleckstrin homology domains 1 isoform 3 [Homo sapiens] Length = 644 Score = 152 bits (384), Expect = 8e-37 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%) Query: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229 ++V D +SK + + T R + L+ KSHC W+LVE L +ER EDHE Sbjct: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384 Query: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287 +V+ + T S++K +F + KY FKNP N+ + T + L + F S Sbjct: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 444 Query: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346 S + PEI+G L +K+ GKKSWKK Y LR SG+Y KG +K R L L+ N++ Sbjct: 445 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 504 Query: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406 R +Y APTD+ L +K +++ +++ ++ LC +D +T W+ R+ KYG LY N Sbjct: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564 Query: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454 Y+ +R S S+ ++S S +S + S + + ++ Q A Sbjct: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616 >gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] Length = 612 Score = 59.7 bits (143), Expect = 7e-09 Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 5/101 (4%) Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533 SQ P ++T H WFHG+ISREES +I+ +G FL+R ++ N ++ L L Sbjct: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCL 207 Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 574 H K+ +++I + D S+ +G KF L QLV+ Y Sbjct: 208 LHEGKVLHYRI---DKDKTGKLSIPEGK-KFDTLWQLVEHY 244 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 4/94 (4%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 +F G I+REE+ + Q G+ DGL+LLR S++ F L++ H +K ++ I E + Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLK 586 +++ G T S L ++ L C LK Sbjct: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104 >gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] Length = 635 Score = 59.7 bits (143), Expect = 7e-09 Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 5/101 (4%) Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533 SQ P ++T H WFHG+ISREES +I+ +G FL+R ++ N ++ L L Sbjct: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCL 207 Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 574 H K+ +++I + D S+ +G KF L QLV+ Y Sbjct: 208 LHEGKVLHYRI---DKDKTGKLSIPEGK-KFDTLWQLVEHY 244 Score = 43.9 bits (102), Expect = 4e-04 Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 4/94 (4%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 +F G I+REE+ + Q G+ DGL+LLR S++ F L++ H +K ++ I E + Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLK 586 +++ G T S L ++ L C LK Sbjct: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104 >gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1 [Homo sapiens] Length = 619 Score = 52.0 bits (123), Expect = 2e-06 Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 4/99 (4%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 +F+G ISR E+ +K G+ DGLFLLR + +VL+L H + +F P E Sbjct: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 591 +++ G +L +FY + LPC L+ C R Sbjct: 67 GTYAIAGGKAHCGP-AELCEFYSRDPDGLPCNLRKPCNR 104 Score = 50.8 bits (120), Expect = 3e-06 Identities = 34/116 (29%), Positives = 56/116 (48%), Gaps = 5/116 (4%) Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533 SQ+P ++T H W+H ++REE+ R + DG FLLR + + L+L Sbjct: 144 SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSL 202 Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHC 589 + + + ++ I D + + +G TKF L QLV++ +L L LK C Sbjct: 203 IYGKTVYHYLI---SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254 >gi|40254823 SH2 containing inositol phosphatase isoform b [Homo sapiens] Length = 1188 Score = 52.0 bits (123), Expect = 2e-06 Identities = 28/84 (33%), Positives = 51/84 (60%), Gaps = 2/84 (2%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 W HG I+R ++ ++ + G DG FL+R S+S +A+ L + + + ++ILP EDD Sbjct: 5 WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKF 63 Query: 553 TFFSLDDGNTK-FSDLIQLVDFYQ 575 T + + + + F+ L QL++FY+ Sbjct: 64 TVQASEGVSMRFFTKLDQLIEFYK 87 >gi|64085167 SH2 containing inositol phosphatase isoform a [Homo sapiens] Length = 1189 Score = 52.0 bits (123), Expect = 2e-06 Identities = 28/84 (33%), Positives = 51/84 (60%), Gaps = 2/84 (2%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 W HG I+R ++ ++ + G DG FL+R S+S +A+ L + + + ++ILP EDD Sbjct: 5 WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKF 63 Query: 553 TFFSLDDGNTK-FSDLIQLVDFYQ 575 T + + + + F+ L QL++FY+ Sbjct: 64 TVQASEGVSMRFFTKLDQLIEFYK 87 >gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] Length = 330 Score = 50.1 bits (118), Expect = 6e-06 Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 9/106 (8%) Query: 472 LGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVL 531 LGSQ P + + WFH +SR ++ ++ G G F++R SQS+P F + Sbjct: 39 LGSQEGYVPKNFIDI--QFPKWFHEGLSRHQAENLL--MGKEVGFFIIRASQSSPGDFSI 94 Query: 532 TLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577 ++ H +++F+++ D+ +F + KF L +LVD+Y+ N Sbjct: 95 SVRHEDDVQHFKVM--RDNKGNYFLWTE---KFPSLNKLVDYYRTN 135 >gi|5729856 GRB2-related adaptor protein [Homo sapiens] Length = 217 Score = 50.1 bits (118), Expect = 6e-06 Identities = 28/83 (33%), Positives = 53/83 (63%), Gaps = 6/83 (7%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 W+ GRISR+ + I+ ++ + G FL+R+S+S+P F +++ + ++++F++L E G+ Sbjct: 60 WYSGRISRQLAEEILMKRNHL-GAFLIRESESSPGEFSVSVNYGDQVQHFKVLR-EASGK 117 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQ 575 F KF+ L +LVDFY+ Sbjct: 118 YFL----WEEKFNSLNELVDFYR 136 >gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens] Length = 1258 Score = 48.1 bits (113), Expect = 2e-05 Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 23/115 (20%) Query: 472 LGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVL 531 LGSQ+P W+H +SR + ++ + G DG FL+RDS+S AF L Sbjct: 14 LGSQAP--------------SWYHRDLSRAAAEELLARAGR-DGSFLVRDSESVAGAFAL 58 Query: 532 TLCHHQKIKNFQILPCEDDGQTFFSLDDGN----TKFSDLIQLVDFY-QLNKGVL 581 + + + + ++ILP DG+ F ++ +F L +L+ Y Q N+G++ Sbjct: 59 CVLYQKHVHTYRILP---DGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLV 110 >gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] Length = 1291 Score = 47.8 bits (112), Expect = 3e-05 Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%) Query: 484 STVIHRTQHWFHGRISREESHRIIKQQ---------GLVDGLFLLRDSQSNPKAFVLTLC 534 ST +H + WFHG++ R I ++ G DG FL+R+S++ + L+ Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600 Query: 535 HHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575 + K+++ +I +D G F L D N F L L+ YQ Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTD-NLVFDSLYDLITHYQ 640 Score = 45.1 bits (105), Expect = 2e-04 Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 8/103 (7%) Query: 485 TVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544 T H ++ W+H ++R ++ ++ + DG FL+R ++ P ++ ++ KIK+ ++ Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVR-KRNEPNSYAISFRAEGKIKHCRV 717 Query: 545 LPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587 + +GQT GN++F L+ L+ +Y+ + KL++ Sbjct: 718 ---QQEGQTVML---GNSEFDSLVDLISYYEKHPLYRKMKLRY 754 >gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] Length = 1290 Score = 47.8 bits (112), Expect = 3e-05 Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%) Query: 484 STVIHRTQHWFHGRISREESHRIIKQQ---------GLVDGLFLLRDSQSNPKAFVLTLC 534 ST +H + WFHG++ R I ++ G DG FL+R+S++ + L+ Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600 Query: 535 HHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575 + K+++ +I +D G F L D N F L L+ YQ Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTD-NLVFDSLYDLITHYQ 640 Score = 45.1 bits (105), Expect = 2e-04 Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 8/103 (7%) Query: 485 TVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544 T H ++ W+H ++R ++ ++ + DG FL+R ++ P ++ ++ KIK+ ++ Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVR-KRNEPNSYAISFRAEGKIKHCRV 717 Query: 545 LPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587 + +GQT GN++F L+ L+ +Y+ + KL++ Sbjct: 718 ---QQEGQTVML---GNSEFDSLVDLISYYEKHPLYRKMKLRY 754 >gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [Homo sapiens] Length = 466 Score = 47.8 bits (112), Expect = 3e-05 Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 WFHG+IS +E+ + + Q DGLFL+R+S +P +VL + + + ++++L DG Sbjct: 81 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 136 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585 ++D+ F +L+ +V+ Y +KG + KL Sbjct: 137 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 166 >gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [Homo sapiens] Length = 508 Score = 47.8 bits (112), Expect = 3e-05 Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 WFHG+IS +E+ + + Q DGLFL+R+S +P +VL + + + ++++L DG Sbjct: 123 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 178 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585 ++D+ F +L+ +V+ Y +KG + KL Sbjct: 179 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 208 >gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [Homo sapiens] Length = 507 Score = 47.8 bits (112), Expect = 3e-05 Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 WFHG+IS +E+ + + Q DGLFL+R+S +P +VL + + + ++++L DG Sbjct: 122 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 177 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585 ++D+ F +L+ +V+ Y +KG + KL Sbjct: 178 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 207 >gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens] Length = 593 Score = 47.4 bits (111), Expect = 4e-05 Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 6/92 (6%) Query: 490 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCED 549 ++ WFH I+ E+ ++ +G VDG FL R S+SNP F L++ + + + +I D Sbjct: 3 SRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGD 61 Query: 550 DGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVL 581 ++ L G KF+ L +LV +Y + G L Sbjct: 62 ----YYDL-YGGEKFATLAELVQYYMEHHGQL 88 Score = 42.7 bits (99), Expect = 0.001 Identities = 18/44 (40%), Positives = 33/44 (75%), Gaps = 1/44 (2%) Query: 490 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533 ++ WFHG +S +E+ +++ ++G G FL+R+SQS+P FVL++ Sbjct: 109 SERWFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSV 151 >gi|5453754 NCK adaptor protein 1 [Homo sapiens] Length = 377 Score = 46.2 bits (108), Expect = 8e-05 Identities = 26/83 (31%), Positives = 51/83 (61%), Gaps = 7/83 (8%) Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552 W++G+++R ++ + ++G +G FL+RDS+S+P F ++L K K+F++ E Sbjct: 282 WYYGKVTRHQAEMALNERGH-EGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKE---- 336 Query: 553 TFFSLDDGNTKFSDLIQLVDFYQ 575 T + + G KFS + +LV+ Y+ Sbjct: 337 TVYCI--GQRKFSTMEELVEHYK 357 >gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo sapiens] Length = 475 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 10/89 (11%) Query: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548 R + W+HGR+SR + R+++ DG FL+RDS +NP +VLT H + K+ ++ E Sbjct: 376 RQEPWYHGRMSRRAAERMLR----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 431 Query: 549 DDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577 +T + F + L+D + N Sbjct: 432 GVVRT------KDVLFESISHLIDHHLQN 454 >gi|169790811 SHC (Src homology 2 domain containing) transforming protein 2 [Homo sapiens] Length = 582 Score = 45.8 bits (107), Expect = 1e-04 Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 10/89 (11%) Query: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548 R + W+HGR+SR + R+++ DG FL+RDS +NP +VLT H + K+ ++ E Sbjct: 483 RQEPWYHGRMSRRAAERMLR----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 538 Query: 549 DDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577 +T + F + L+D + N Sbjct: 539 GVVRT------KDVLFESISHLIDHHLQN 561 >gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] Length = 822 Score = 45.4 bits (106), Expect = 1e-04 Identities = 51/200 (25%), Positives = 92/200 (46%), Gaps = 26/200 (13%) Query: 401 MLLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGR----VIENPAEAQSA-A 455 +LL Q + + ++++ T + ++ L+ G+ V+ +A+S + Sbjct: 352 LLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTS 411 Query: 456 LEEGHAWRK-RSTRMNILG----SQSPLHPSTLSTVIHRT------QHWFHGRISREESH 504 +E K S R +I G +S L S LS +I + Q W+HG I R E+ Sbjct: 412 MERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQ 471 Query: 505 RIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKF 564 ++K+Q G FL+R+S P +VL++ + ++F I+ D+ F T F Sbjct: 472 ELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHF-IIQYVDNMYRF-----EGTGF 521 Query: 565 SDLIQLVDFYQLNKGVLPCK 584 S++ QL+D + K V+ K Sbjct: 522 SNIPQLIDHHYTTKQVITKK 541 >gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] Length = 526 Score = 44.7 bits (104), Expect = 2e-04 Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 12/145 (8%) Query: 452 QSAALEE-GHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQ 510 Q LEE G W+ RS G + + + ++ T+ WF ISR+++ R + Sbjct: 104 QMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSL--ETEEWFFKGISRKDAERQLLAP 161 Query: 511 GLVDGLFLLRDSQSNPKAFVLTLCHH-----QKIKNFQILPCEDDGQTFFSLDDGNTKFS 565 G + G F++RDS++ ++ L++ + +K+++I ++ G F + +T FS Sbjct: 162 GNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG---FYISPRST-FS 217 Query: 566 DLIQLVDFYQLNKGVLPCKLKHHCI 590 L +LVD Y+ L KL C+ Sbjct: 218 TLQELVDHYKKGNDGLCQKLSVPCM 242 >gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] Length = 380 Score = 44.7 bits (104), Expect = 2e-04 Identities = 41/166 (24%), Positives = 77/166 (46%), Gaps = 23/166 (13%) Query: 423 PVRSVSENSLVAMDFS-GQTGRVIENPA---EAQSAALEEGHAWRKRSTRMNILGSQSPL 478 P SV+E L +F G+T VIE P E G + +L L Sbjct: 205 PFSSVTEEEL---NFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPAL 261 Query: 479 HPSTLSTVIHRT---------QHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAF 529 HP+ + + + W++G ++R ++ + ++G V+G FL+RDS+S+P F Sbjct: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320 Query: 530 VLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575 ++L K K+F++ ++ + + G +F + +LV+ Y+ Sbjct: 321 SVSLKASGKNKHFKVQLVDN----VYCI--GQRRFHTMDELVEHYK 360 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.133 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,941,421 Number of Sequences: 37866 Number of extensions: 1185178 Number of successful extensions: 5112 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 57 Number of HSP's successfully gapped in prelim test: 149 Number of HSP's that attempted gapping in prelim test: 4851 Number of HSP's gapped (non-prelim): 337 length of query: 594 length of database: 18,247,518 effective HSP length: 108 effective length of query: 486 effective length of database: 14,157,990 effective search space: 6880783140 effective search space used: 6880783140 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.