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Search of human proteins with 48762679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48762679 growth factor receptor-bound protein 10 isoform a
[Homo sapiens]
(594 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48762679 growth factor receptor-bound protein 10 isoform a [H... 1216 0.0
gi|48762693 growth factor receptor-bound protein 10 isoform b [H... 1098 0.0
gi|48762697 growth factor receptor-bound protein 10 isoform c [H... 1095 0.0
gi|48762695 growth factor receptor-bound protein 10 isoform c [H... 1095 0.0
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens] 573 e-163
gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens] 550 e-156
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens] 550 e-156
gi|56118221 amyloid beta (A4) precursor protein-binding, family ... 160 3e-39
gi|47132519 Ras association and pleckstrin homology domains 1 is... 152 8e-37
gi|42740893 Ras association and pleckstrin homology domains 1 is... 152 8e-37
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 60 7e-09
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 60 7e-09
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 52 2e-06
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 52 2e-06
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 52 2e-06
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 50 6e-06
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 50 6e-06
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 48 2e-05
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 48 3e-05
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 48 3e-05
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 48 3e-05
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 48 3e-05
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 48 3e-05
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 47 4e-05
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 46 8e-05
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 46 1e-04
gi|169790811 SHC (Src homology 2 domain containing) transforming... 46 1e-04
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 45 1e-04
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 45 2e-04
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 45 2e-04
>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
sapiens]
Length = 594
Score = 1216 bits (3146), Expect = 0.0
Identities = 594/594 (100%), Positives = 594/594 (100%)
Query: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN
Sbjct: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60
Query: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120
ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV
Sbjct: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120
Query: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180
RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
Sbjct: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180
Query: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE
Sbjct: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240
Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300
SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK
Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300
Query: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360
ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
Sbjct: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360
Query: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420
GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF
Sbjct: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420
Query: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480
STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP
Sbjct: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480
Query: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540
STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK
Sbjct: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540
Query: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
>gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo
sapiens]
Length = 548
Score = 1098 bits (2840), Expect = 0.0
Identities = 548/594 (92%), Positives = 548/594 (92%), Gaps = 46/594 (7%)
Query: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN
Sbjct: 1 MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMN 60
Query: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120
ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV
Sbjct: 61 ASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAV 120
Query: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180
RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK
Sbjct: 121 RRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSK 180
Query: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240
VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE
Sbjct: 181 VVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMASE 240
Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLHVK 300
SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQ
Sbjct: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQ------------------ 282
Query: 301 ELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 360
EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH
Sbjct: 283 ----------------------------EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDH 314
Query: 361 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 420
GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF
Sbjct: 315 GLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF 374
Query: 421 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 480
STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP
Sbjct: 375 STPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHP 434
Query: 481 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 540
STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK
Sbjct: 435 STLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIK 494
Query: 541 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 495 NFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 548
>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
sapiens]
Length = 536
Score = 1095 bits (2831), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 59 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 118
MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL
Sbjct: 1 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 60
Query: 119 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 178
AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT
Sbjct: 61 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 120
Query: 179 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 238
SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA
Sbjct: 121 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 180
Query: 239 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 298
SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH
Sbjct: 181 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 240
Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT
Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300
Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418
DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS
Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 360
Query: 419 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 478
PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL
Sbjct: 361 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 420
Query: 479 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 538
HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK
Sbjct: 421 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 480
Query: 539 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 481 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536
>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
sapiens]
Length = 536
Score = 1095 bits (2831), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 59 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 118
MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL
Sbjct: 1 MNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHIL 60
Query: 119 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 178
AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT
Sbjct: 61 AVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGT 120
Query: 179 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 238
SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA
Sbjct: 121 SKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVESTMA 180
Query: 239 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 298
SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH
Sbjct: 181 SESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNSSSCPEIQGFLH 240
Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT
Sbjct: 241 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 300
Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418
DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS
Sbjct: 301 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 360
Query: 419 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 478
PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL
Sbjct: 361 PFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPL 420
Query: 479 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 538
HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK
Sbjct: 421 HPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQK 480
Query: 539 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
Sbjct: 481 IKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536
>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
Length = 540
Score = 573 bits (1477), Expect = e-163
Identities = 297/539 (55%), Positives = 385/539 (71%), Gaps = 27/539 (5%)
Query: 80 LQNGQHARSQPRASGPPRSIQ-----------------PQVSPRQRVQRSQPVHILAVRR 122
LQ+GQ A S+ A P + Q P + R + A R
Sbjct: 5 LQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADR 64
Query: 123 LQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQDVKVFSEDGTSKVV 182
+++D +P+IPNPFPELC VL+ P + + KQ +KV+SED TS+ +
Sbjct: 65 RKKKDLD--VPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRAL 122
Query: 183 EILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASE 240
++ +D+TARD+CQLL+ K+H +DD+SWTL EH PH+G+ER +EDHELV++V S + E
Sbjct: 123 DVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEE 182
Query: 241 SKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLH 298
+K FRKNYAKYEFFKNPM FFPE MV++ ++NG S TQ+LQ FL+SS+ PEI GFLH
Sbjct: 183 NKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLH 242
Query: 299 VKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPT 358
KE GKKSWKK+Y LRRSGLY STKGTSKEPRHLQ ++ +S+I+ +AG+K++ APT
Sbjct: 243 AKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPT 302
Query: 359 DHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQ-RKALL 417
++G C KPNK ++L++LCAE+EQ+RTCW+TA RLLKYGM LYQNY P Q R
Sbjct: 303 NYGFCFKPNKAGGP-RDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCS 361
Query: 418 SPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSAALEEGHAWRKRST-RMNILGSQS 476
S +P+RS+SENSLVAMDFSGQ RVIENP EA S A+EEG AWRK+ R+ GS +
Sbjct: 362 SQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPT 421
Query: 477 PLHPSTLSTV-IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCH 535
S+ + + IHR+Q WFH +ISR+E+ R+I QQGLVDG+FL+RDSQSNPK FVL++ H
Sbjct: 422 ASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSH 481
Query: 536 HQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
QKIK+FQI+P EDDG+ F +LDDG+T+F+DLIQLV+FYQLNKGVLPCKLKH+C R+AL
Sbjct: 482 GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL 540
>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
Length = 532
Score = 550 bits (1418), Expect = e-156
Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)
Query: 90 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147
P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC
Sbjct: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
Query: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202
P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H
Sbjct: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
Query: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259
+ D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P
Sbjct: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
Query: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317
+ FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS
Sbjct: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
Query: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377
GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR
Sbjct: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
Query: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436
+ C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD
Sbjct: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
Query: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496
FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG
Sbjct: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
Query: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556
RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
Query: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
+DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
Length = 532
Score = 550 bits (1418), Expect = e-156
Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)
Query: 90 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147
P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC
Sbjct: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
Query: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202
P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H
Sbjct: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
Query: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259
+ D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P
Sbjct: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
Query: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317
+ FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS
Sbjct: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
Query: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377
GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR
Sbjct: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
Query: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436
+ C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD
Sbjct: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
Query: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496
FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG
Sbjct: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
Query: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556
RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
Query: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
+DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
member 1 interacting protein [Homo sapiens]
Length = 666
Score = 160 bits (405), Expect = 3e-39
Identities = 123/400 (30%), Positives = 185/400 (46%), Gaps = 50/400 (12%)
Query: 48 DDVDLEALVNDMNASL-ESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPR 106
+D DL+AL+ D+ A + E+ Q ++ LQN H+ S +Q +
Sbjct: 60 EDQDLDALMADLVADISEAEQRTIQAQKES---LQNQHHSAS----------LQASIFSG 106
Query: 107 QRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAA 166
++ A Q ED + P + P P PP P S +A A
Sbjct: 107 A-ASLGYGTNVAATGISQYEDDLPPPPADPVLDLPLP-------PPPPEPLSQEEEEAQA 158
Query: 167 KQD------------------VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNS 208
K D VKV D ++K + + ARD+ L K+HC +
Sbjct: 159 KADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVD 218
Query: 209 WTLVEHHPHLGLERCLEDHELVVQVES--TMASESKFLFRKNYAKYEFFKNPMNFF---- 262
W L E +P L +ER EDHE VV+V S T +E+K LF + KY FKNP NF+
Sbjct: 219 WCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNR 278
Query: 263 --PEQMVTWCQQSNGSQTQLLQNFLNSSSC--PEIQGFLHVKELGKKSWKKLYVCLRRSG 318
E T + + ++ LL+ +S PE++G L++KE GKKSWK+ Y LR SG
Sbjct: 279 GKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASG 338
Query: 319 LYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELRL 378
+Y KG +K R L E+ NI+ + +Y APTD+ +K +++ E++ ++
Sbjct: 339 IYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKY 398
Query: 379 LCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLS 418
LC +D +T W+ R+ KYG LY NY+ + L S
Sbjct: 399 LCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLAS 438
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 152 bits (384), Expect = 8e-37
Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)
Query: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229
++V D +SK + + T R + L+ KSHC W+LVE L +ER EDHE
Sbjct: 273 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 332
Query: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287
+V+ + T S++K +F + KY FKNP N+ + T + L + F S
Sbjct: 333 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 392
Query: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346
S + PEI+G L +K+ GKKSWKK Y LR SG+Y KG +K R L L+ N++
Sbjct: 393 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 452
Query: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406
R +Y APTD+ L +K +++ +++ ++ LC +D +T W+ R+ KYG LY N
Sbjct: 453 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 512
Query: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454
Y+ +R S S+ ++S S +S + S + + ++ Q A
Sbjct: 513 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 564
>gi|42740893 Ras association and pleckstrin homology domains 1
isoform 3 [Homo sapiens]
Length = 644
Score = 152 bits (384), Expect = 8e-37
Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)
Query: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229
++V D +SK + + T R + L+ KSHC W+LVE L +ER EDHE
Sbjct: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384
Query: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287
+V+ + T S++K +F + KY FKNP N+ + T + L + F S
Sbjct: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 444
Query: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346
S + PEI+G L +K+ GKKSWKK Y LR SG+Y KG +K R L L+ N++
Sbjct: 445 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 504
Query: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406
R +Y APTD+ L +K +++ +++ ++ LC +D +T W+ R+ KYG LY N
Sbjct: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564
Query: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454
Y+ +R S S+ ++S S +S + S + + ++ Q A
Sbjct: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 59.7 bits (143), Expect = 7e-09
Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 5/101 (4%)
Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
SQ P ++T H WFHG+ISREES +I+ +G FL+R ++ N ++ L L
Sbjct: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCL 207
Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 574
H K+ +++I + D S+ +G KF L QLV+ Y
Sbjct: 208 LHEGKVLHYRI---DKDKTGKLSIPEGK-KFDTLWQLVEHY 244
Score = 43.9 bits (102), Expect = 4e-04
Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 4/94 (4%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
+F G I+REE+ + Q G+ DGL+LLR S++ F L++ H +K ++ I E +
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLK 586
+++ G T S L ++ L C LK
Sbjct: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 59.7 bits (143), Expect = 7e-09
Identities = 36/101 (35%), Positives = 55/101 (54%), Gaps = 5/101 (4%)
Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
SQ P ++T H WFHG+ISREES +I+ +G FL+R ++ N ++ L L
Sbjct: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCL 207
Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 574
H K+ +++I + D S+ +G KF L QLV+ Y
Sbjct: 208 LHEGKVLHYRI---DKDKTGKLSIPEGK-KFDTLWQLVEHY 244
Score = 43.9 bits (102), Expect = 4e-04
Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 4/94 (4%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
+F G I+REE+ + Q G+ DGL+LLR S++ F L++ H +K ++ I E +
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLK 586
+++ G T S L ++ L C LK
Sbjct: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 4/99 (4%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
+F+G ISR E+ +K G+ DGLFLLR + +VL+L H + +F P E
Sbjct: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 591
+++ G +L +FY + LPC L+ C R
Sbjct: 67 GTYAIAGGKAHCGP-AELCEFYSRDPDGLPCNLRKPCNR 104
Score = 50.8 bits (120), Expect = 3e-06
Identities = 34/116 (29%), Positives = 56/116 (48%), Gaps = 5/116 (4%)
Query: 474 SQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
SQ+P ++T H W+H ++REE+ R + DG FLLR + + L+L
Sbjct: 144 SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSL 202
Query: 534 CHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHC 589
+ + + ++ I D + + +G TKF L QLV++ +L L LK C
Sbjct: 203 IYGKTVYHYLI---SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254
>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
sapiens]
Length = 1188
Score = 52.0 bits (123), Expect = 2e-06
Identities = 28/84 (33%), Positives = 51/84 (60%), Gaps = 2/84 (2%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
W HG I+R ++ ++ + G DG FL+R S+S +A+ L + + + ++ILP EDD
Sbjct: 5 WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKF 63
Query: 553 TFFSLDDGNTK-FSDLIQLVDFYQ 575
T + + + + F+ L QL++FY+
Sbjct: 64 TVQASEGVSMRFFTKLDQLIEFYK 87
>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
sapiens]
Length = 1189
Score = 52.0 bits (123), Expect = 2e-06
Identities = 28/84 (33%), Positives = 51/84 (60%), Gaps = 2/84 (2%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
W HG I+R ++ ++ + G DG FL+R S+S +A+ L + + + ++ILP EDD
Sbjct: 5 WNHGNITRSKAEELLSRTGK-DGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKF 63
Query: 553 TFFSLDDGNTK-FSDLIQLVDFYQ 575
T + + + + F+ L QL++FY+
Sbjct: 64 TVQASEGVSMRFFTKLDQLIEFYK 87
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 50.1 bits (118), Expect = 6e-06
Identities = 31/106 (29%), Positives = 56/106 (52%), Gaps = 9/106 (8%)
Query: 472 LGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVL 531
LGSQ P + + WFH +SR ++ ++ G G F++R SQS+P F +
Sbjct: 39 LGSQEGYVPKNFIDI--QFPKWFHEGLSRHQAENLL--MGKEVGFFIIRASQSSPGDFSI 94
Query: 532 TLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577
++ H +++F+++ D+ +F + KF L +LVD+Y+ N
Sbjct: 95 SVRHEDDVQHFKVM--RDNKGNYFLWTE---KFPSLNKLVDYYRTN 135
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 50.1 bits (118), Expect = 6e-06
Identities = 28/83 (33%), Positives = 53/83 (63%), Gaps = 6/83 (7%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
W+ GRISR+ + I+ ++ + G FL+R+S+S+P F +++ + ++++F++L E G+
Sbjct: 60 WYSGRISRQLAEEILMKRNHL-GAFLIRESESSPGEFSVSVNYGDQVQHFKVLR-EASGK 117
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQ 575
F KF+ L +LVDFY+
Sbjct: 118 YFL----WEEKFNSLNELVDFYR 136
>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo
sapiens]
Length = 1258
Score = 48.1 bits (113), Expect = 2e-05
Identities = 34/115 (29%), Positives = 58/115 (50%), Gaps = 23/115 (20%)
Query: 472 LGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVL 531
LGSQ+P W+H +SR + ++ + G DG FL+RDS+S AF L
Sbjct: 14 LGSQAP--------------SWYHRDLSRAAAEELLARAGR-DGSFLVRDSESVAGAFAL 58
Query: 532 TLCHHQKIKNFQILPCEDDGQTFFSLDDGN----TKFSDLIQLVDFY-QLNKGVL 581
+ + + + ++ILP DG+ F ++ +F L +L+ Y Q N+G++
Sbjct: 59 CVLYQKHVHTYRILP---DGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLV 110
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%)
Query: 484 STVIHRTQHWFHGRISREESHRIIKQQ---------GLVDGLFLLRDSQSNPKAFVLTLC 534
ST +H + WFHG++ R I ++ G DG FL+R+S++ + L+
Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600
Query: 535 HHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575
+ K+++ +I +D G F L D N F L L+ YQ
Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTD-NLVFDSLYDLITHYQ 640
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 8/103 (7%)
Query: 485 TVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544
T H ++ W+H ++R ++ ++ + DG FL+R ++ P ++ ++ KIK+ ++
Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVR-KRNEPNSYAISFRAEGKIKHCRV 717
Query: 545 LPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587
+ +GQT GN++F L+ L+ +Y+ + KL++
Sbjct: 718 ---QQEGQTVML---GNSEFDSLVDLISYYEKHPLYRKMKLRY 754
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%)
Query: 484 STVIHRTQHWFHGRISREESHRIIKQQ---------GLVDGLFLLRDSQSNPKAFVLTLC 534
ST +H + WFHG++ R I ++ G DG FL+R+S++ + L+
Sbjct: 541 STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW 600
Query: 535 HHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575
+ K+++ +I +D G F L D N F L L+ YQ
Sbjct: 601 RNGKVQHCRIHSRQDAGTPKFFLTD-NLVFDSLYDLITHYQ 640
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 8/103 (7%)
Query: 485 TVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 544
T H ++ W+H ++R ++ ++ + DG FL+R ++ P ++ ++ KIK+ ++
Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPR-DGAFLVR-KRNEPNSYAISFRAEGKIKHCRV 717
Query: 545 LPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKH 587
+ +GQT GN++F L+ L+ +Y+ + KL++
Sbjct: 718 ---QQEGQTVML---GNSEFDSLVDLISYYEKHPLYRKMKLRY 754
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
WFHG+IS +E+ + + Q DGLFL+R+S +P +VL + + + ++++L DG
Sbjct: 81 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 136
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585
++D+ F +L+ +V+ Y +KG + KL
Sbjct: 137 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 166
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
WFHG+IS +E+ + + Q DGLFL+R+S +P +VL + + + ++++L DG
Sbjct: 123 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 178
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585
++D+ F +L+ +V+ Y +KG + KL
Sbjct: 179 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 208
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/93 (32%), Positives = 55/93 (59%), Gaps = 7/93 (7%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
WFHG+IS +E+ + + Q DGLFL+R+S +P +VL + + + ++++L DG
Sbjct: 122 WFHGKISGQEA--VQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 177
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKL 585
++D+ F +L+ +V+ Y +KG + KL
Sbjct: 178 --LTIDEA-VFFCNLMDMVEHYSKDKGAICTKL 207
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 47.4 bits (111), Expect = 4e-05
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 6/92 (6%)
Query: 490 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCED 549
++ WFH I+ E+ ++ +G VDG FL R S+SNP F L++ + + + +I D
Sbjct: 3 SRRWFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGD 61
Query: 550 DGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVL 581
++ L G KF+ L +LV +Y + G L
Sbjct: 62 ----YYDL-YGGEKFATLAELVQYYMEHHGQL 88
Score = 42.7 bits (99), Expect = 0.001
Identities = 18/44 (40%), Positives = 33/44 (75%), Gaps = 1/44 (2%)
Query: 490 TQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTL 533
++ WFHG +S +E+ +++ ++G G FL+R+SQS+P FVL++
Sbjct: 109 SERWFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSV 151
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 46.2 bits (108), Expect = 8e-05
Identities = 26/83 (31%), Positives = 51/83 (61%), Gaps = 7/83 (8%)
Query: 493 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 552
W++G+++R ++ + ++G +G FL+RDS+S+P F ++L K K+F++ E
Sbjct: 282 WYYGKVTRHQAEMALNERGH-EGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKE---- 336
Query: 553 TFFSLDDGNTKFSDLIQLVDFYQ 575
T + + G KFS + +LV+ Y+
Sbjct: 337 TVYCI--GQRKFSTMEELVEHYK 357
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 45.8 bits (107), Expect = 1e-04
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 10/89 (11%)
Query: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548
R + W+HGR+SR + R+++ DG FL+RDS +NP +VLT H + K+ ++ E
Sbjct: 376 RQEPWYHGRMSRRAAERMLR----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 431
Query: 549 DDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577
+T + F + L+D + N
Sbjct: 432 GVVRT------KDVLFESISHLIDHHLQN 454
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 45.8 bits (107), Expect = 1e-04
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 10/89 (11%)
Query: 489 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCE 548
R + W+HGR+SR + R+++ DG FL+RDS +NP +VLT H + K+ ++ E
Sbjct: 483 RQEPWYHGRMSRRAAERMLR----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPE 538
Query: 549 DDGQTFFSLDDGNTKFSDLIQLVDFYQLN 577
+T + F + L+D + N
Sbjct: 539 GVVRT------KDVLFESISHLIDHHLQN 561
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 45.4 bits (106), Expect = 1e-04
Identities = 51/200 (25%), Positives = 92/200 (46%), Gaps = 26/200 (13%)
Query: 401 MLLYQNYRIPQQRKALLSPFSTPVRSVSENSLVAMDFSGQTGR----VIENPAEAQSA-A 455
+LL Q + + ++++ T + ++ L+ G+ V+ +A+S +
Sbjct: 352 LLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTS 411
Query: 456 LEEGHAWRK-RSTRMNILG----SQSPLHPSTLSTVIHRT------QHWFHGRISREESH 504
+E K S R +I G +S L S LS +I + Q W+HG I R E+
Sbjct: 412 MERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQ 471
Query: 505 RIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKF 564
++K+Q G FL+R+S P +VL++ + ++F I+ D+ F T F
Sbjct: 472 ELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHF-IIQYVDNMYRF-----EGTGF 521
Query: 565 SDLIQLVDFYQLNKGVLPCK 584
S++ QL+D + K V+ K
Sbjct: 522 SNIPQLIDHHYTTKQVITKK 541
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 12/145 (8%)
Query: 452 QSAALEE-GHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHGRISREESHRIIKQQ 510
Q LEE G W+ RS G + + + ++ T+ WF ISR+++ R +
Sbjct: 104 QMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSL--ETEEWFFKGISRKDAERQLLAP 161
Query: 511 GLVDGLFLLRDSQSNPKAFVLTLCHH-----QKIKNFQILPCEDDGQTFFSLDDGNTKFS 565
G + G F++RDS++ ++ L++ + +K+++I ++ G F + +T FS
Sbjct: 162 GNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG---FYISPRST-FS 217
Query: 566 DLIQLVDFYQLNKGVLPCKLKHHCI 590
L +LVD Y+ L KL C+
Sbjct: 218 TLQELVDHYKKGNDGLCQKLSVPCM 242
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 44.7 bits (104), Expect = 2e-04
Identities = 41/166 (24%), Positives = 77/166 (46%), Gaps = 23/166 (13%)
Query: 423 PVRSVSENSLVAMDFS-GQTGRVIENPA---EAQSAALEEGHAWRKRSTRMNILGSQSPL 478
P SV+E L +F G+T VIE P E G + +L L
Sbjct: 205 PFSSVTEEEL---NFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPAL 261
Query: 479 HPSTLSTVIHRT---------QHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAF 529
HP+ + + + W++G ++R ++ + ++G V+G FL+RDS+S+P F
Sbjct: 262 HPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERG-VEGDFLIRDSESSPSDF 320
Query: 530 VLTLCHHQKIKNFQILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQ 575
++L K K+F++ ++ + + G +F + +LV+ Y+
Sbjct: 321 SVSLKASGKNKHFKVQLVDN----VYCI--GQRRFHTMDELVEHYK 360
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,941,421
Number of Sequences: 37866
Number of extensions: 1185178
Number of successful extensions: 5112
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 4851
Number of HSP's gapped (non-prelim): 337
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.