Search of human proteins with 4827022

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4827022 contactin 2 precursor [Homo sapiens]
         (1040 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4827022 contactin 2 precursor [Homo sapiens]                      2117   0.0  
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]            985   0.0  
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]            985   0.0  
gi|28373129 contactin 5 isoform short [Homo sapiens]                  899   0.0  
gi|75709184 contactin 3 [Homo sapiens]                                899   0.0  
gi|7657359 contactin 5 isoform long [Homo sapiens]                    898   0.0  
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            897   0.0  
gi|7657361 contactin 6 [Homo sapiens]                                 857   0.0  
gi|28373126 contactin 4 isoform c precursor [Homo sapiens]            653   0.0  
gi|27894376 cell adhesion molecule with homology to L1CAM precur...   395   e-109
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   386   e-107
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   386   e-107
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   386   e-107
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   376   e-104
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   372   e-102
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]           365   e-100
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]            365   e-100
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]           357   4e-98
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]           348   2e-95
gi|119220552 sidekick 1 [Homo sapiens]                                294   3e-79
gi|222352127 sidekick 2 [Homo sapiens]                                282   1e-75
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   231   2e-60
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]           226   9e-59
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]           226   9e-59
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   215   2e-55
gi|28373124 contactin 4 isoform b precursor [Homo sapiens]            212   1e-54
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   203   8e-52
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   203   8e-52
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...   202   2e-51
gi|157311649 neogenin homolog 1 [Homo sapiens]                        198   2e-50

>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score = 2117 bits (5486), Expect = 0.0
 Identities = 1040/1040 (100%), Positives = 1040/1040 (100%)

Query: 1    MGTATRRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLA 60
            MGTATRRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLA
Sbjct: 1    MGTATRRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLA 60

Query: 61   CRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTV 120
            CRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTV
Sbjct: 61   CRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTV 120

Query: 121  VSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTD 180
            VSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTD
Sbjct: 121  VSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTD 180

Query: 181  GRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPS 240
            GRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPS
Sbjct: 181  GRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPS 240

Query: 241  IKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFED 300
            IKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFED
Sbjct: 241  IKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFED 300

Query: 301  EGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRW 360
            EGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRW
Sbjct: 301  EGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRW 360

Query: 361  LRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFR 420
            LRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFR
Sbjct: 361  LRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFR 420

Query: 421  LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISR 480
            LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISR
Sbjct: 421  LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISR 480

Query: 481  SDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDL 540
            SDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDL
Sbjct: 481  SDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDL 540

Query: 541  TFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEA 600
            TFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEA
Sbjct: 541  TFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEA 600

Query: 601  TVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNP 660
            TVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNP
Sbjct: 601  TVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNP 660

Query: 661  ANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGG 720
            ANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGG
Sbjct: 661  ANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGG 720

Query: 721  GGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRP 780
            GGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRP
Sbjct: 721  GGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRP 780

Query: 781  YTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDM 840
            YTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDM
Sbjct: 781  YTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDM 840

Query: 841  NGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900
            NGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPAS
Sbjct: 841  NGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900

Query: 901  PSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPT 960
            PSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPT
Sbjct: 901  PSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPT 960

Query: 961  LHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVENMAVRPAPH 1020
            LHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVENMAVRPAPH
Sbjct: 961  LHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVENMAVRPAPH 1020

Query: 1021 PGTVISHSVAMLILIGSLEL 1040
            PGTVISHSVAMLILIGSLEL
Sbjct: 1021 PGTVISHSVAMLILIGSLEL 1040


>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
          Length = 1018

 Score =  985 bits (2547), Expect = 0.0
 Identities = 507/1003 (50%), Positives = 672/1003 (66%), Gaps = 31/1003 (3%)

Query: 10   HLLLVAAVALVSSSAWSSALGSQTT-----FGPVFEDQPLSVLFPEESTEEQVLLACRAR 64
            HL++++    ++   W    G   +     FGP+FE+QP++ ++PEES E +V L CRAR
Sbjct: 9    HLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRAR 68

Query: 65   ASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSRE 124
            ASP   Y+W+MN  ++ L    R+ +VGGNLVI NP K +DAG+Y CLASN  G V S E
Sbjct: 69   ASPFPVYKWRMNNGDVDLT-SDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTE 127

Query: 125  AILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPG-LSYRWLLNEFPNFIPTDGRH 183
            A L FG+L  F  EER  V+  EG G++L C+PP H+P  LSYRWLLNEFP FI  D R 
Sbjct: 128  ATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRR 187

Query: 184  FVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQL-NLAAEDTRLFAPSIK 242
            FVSQT GNLYIA   ASD GNYSC  +S     TKSVFSKF  L  +    T+ +   I 
Sbjct: 188  FVSQTNGNLYIANVEASDKGNYSCFVSSPS--ITKSVFSKFIPLIPIPERTTKPYPADIV 245

Query: 243  ARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAE-----PTLQIPSVS 297
             +F  + YAL+GQ VTLECFA GNPVP I+WRKV   L P  +TAE       L+I ++ 
Sbjct: 246  VQFK-DVYALMGQNVTLECFALGNPVPDIRWRKV---LEPMPSTAEISTSGAVLKIFNIQ 301

Query: 298  FEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPT 357
             EDEG YECEAEN +G+D  Q RI VQA PEW++ I+DTE DIGS+L W C A GKP PT
Sbjct: 302  LEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPT 361

Query: 358  VRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAP 417
            +RWL+NG             G+LR   ++ E++GMYQC+AEN +G IYA+AEL + ALAP
Sbjct: 362  IRWLKNGYAYHK--------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAP 413

Query: 418  DFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRN 477
             F +NP+++ I AA+GG ++I C+P+AAPK    WSKGTE LVNSSR+ +  DG+L I N
Sbjct: 414  TFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINN 473

Query: 478  ISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPT 537
            I+R+D G YTCFAEN  GKANSTG L + D T+I LAP +ADI +G+N T+QC AS DP 
Sbjct: 474  ITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPA 533

Query: 538  MDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSAS 597
            +DLTF W+ + + IDF+K   HY+R  + ++ G+L I NAQL+H G+YTC AQT+VD++S
Sbjct: 534  LDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSS 593

Query: 598  KEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVR 657
              A ++VRGPPGPPGG+ + DI  T++ L+WSRG DNHSPI+KYT+Q +T  +  WK  +
Sbjct: 594  ASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAK 653

Query: 658  TNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGL 717
            T+P  IEGN E A+ + L PWM+YEFRV+A+N LG GEPS PS++I+T  AAP+VAPS +
Sbjct: 654  TDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDV 713

Query: 718  SGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNES 777
             GGGG   EL + W P+SREY  G+ FGY+++F+      W+   V   D   +V+ +E+
Sbjct: 714  GGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDET 773

Query: 778  VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ 837
            + P T F+VK++++N +GDGP SL A++ SA++ P  APT+V  K +SSSE++V WE V 
Sbjct: 774  MSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHV- 832

Query: 838  QDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTG 897
              +  I+  Y+IRYW A DKE AA+RV+    + SAR+  L P+T+Y + V A N AG G
Sbjct: 833  --LEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCG 890

Query: 898  PASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHL 957
            P S    A T K PP +PP  IS   S S   I WD VV   NES VTGYK+LY+ D   
Sbjct: 891  PPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQH 950

Query: 958  TPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHI 1000
               L+ T K+ IE+P+P D G  +V++R    GGDG+ ++V I
Sbjct: 951  DGKLYSTHKHSIEVPIPRD-GEYVVEVRAHSDGGDGVVSQVKI 992


>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
          Length = 1007

 Score =  985 bits (2546), Expect = 0.0
 Identities = 507/996 (50%), Positives = 671/996 (67%), Gaps = 26/996 (2%)

Query: 12   LLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATY 71
            LLV+ + ++S +   +       FGP+FE+QP++ ++PEES E +V L CRARASP   Y
Sbjct: 5    LLVSHLVIISITTCLAVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVY 64

Query: 72   RWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGF 131
            +W+MN  ++ L    R+ +VGGNLVI NP K +DAG+Y CLASN  G V S EA L FG+
Sbjct: 65   KWRMNNGDVDLT-SDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGY 123

Query: 132  LQEFSKEERDPVKAHEGWGVMLPCNPPAHYPG-LSYRWLLNEFPNFIPTDGRHFVSQTTG 190
            L  F  EER  V+  EG G++L C+PP H+P  LSYRWLLNEFP FI  D R FVSQT G
Sbjct: 124  LDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNG 183

Query: 191  NLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQL-NLAAEDTRLFAPSIKARFPAET 249
            NLYIA   ASD GNYSC  +S     TKSVFSKF  L  +    T+ +   I  +F  + 
Sbjct: 184  NLYIANVEASDKGNYSCFVSSPS--ITKSVFSKFIPLIPIPERTTKPYPADIVVQFK-DV 240

Query: 250  YALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAE-----PTLQIPSVSFEDEGTY 304
            YAL+GQ VTLECFA GNPVP I+WRKV   L P  +TAE       L+I ++  EDEG Y
Sbjct: 241  YALMGQNVTLECFALGNPVPDIRWRKV---LEPMPSTAEISTSGAVLKIFNIQLEDEGIY 297

Query: 305  ECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG 364
            ECEAEN +G+D  Q RI VQA PEW++ I+DTE DIGS+L W C A GKP PT+RWL+NG
Sbjct: 298  ECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNG 357

Query: 365  EPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPV 424
                         G+LR   ++ E++GMYQC+AEN +G IYA+AEL + ALAP F +NP+
Sbjct: 358  YAYHK--------GELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 409

Query: 425  RRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEG 484
            ++ I AA+GG ++I C+P+AAPK    WSKGTE LVNSSR+ +  DG+L I NI+R+D G
Sbjct: 410  KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG 469

Query: 485  KYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTW 544
             YTCFAEN  GKANSTG L + D T+I LAP +ADI +G+N T+QC AS DP +DLTF W
Sbjct: 470  IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW 529

Query: 545  TLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
            + + + IDF+K   HY+R  + ++ G+L I NAQL+H G+YTC AQT+VD++S  A ++V
Sbjct: 530  SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV 589

Query: 605  RGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIE 664
            RGPPGPPGG+ + DI  T++ L+WSRG DNHSPI+KYT+Q +T  +  WK  +T+P  IE
Sbjct: 590  RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE 649

Query: 665  GNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAP 724
            GN E A+ + L PWM+YEFRV+A+N LG GEPS PS++I+T  AAP+VAPS + GGGG  
Sbjct: 650  GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN 709

Query: 725  GELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPF 784
             EL + W P+SREY  G+ FGY+++F+      W+   V   D   +V+ +E++ P T F
Sbjct: 710  RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF 769

Query: 785  EVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGIL 844
            +VK++++N +GDGP SL A++ SA++ P  APT+V  K +SSSE++V WE V   +  I+
Sbjct: 770  QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHV---LEKIV 826

Query: 845  LGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSAN 904
              Y+IRYW A DKE AA+RV+    + SAR+  L P+T+Y + V A N AG GP S    
Sbjct: 827  ESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIE 886

Query: 905  ATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLT 964
            A T K PP +PP  IS   S S   I WD VV   NES VTGYK+LY+ D      L+ T
Sbjct: 887  AFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYST 946

Query: 965  GKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHI 1000
             K+ IE+P+P D G  +V++R    GGDG+ ++V I
Sbjct: 947  HKHSIEVPIPRD-GEYVVEVRAHSDGGDGVVSQVKI 981


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score =  899 bits (2324), Expect = 0.0
 Identities = 436/968 (45%), Positives = 614/968 (63%), Gaps = 7/968 (0%)

Query: 29  LGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRH 88
           L     +GPVF  +P  ++FP +S E++V L C  R +P  +YRW  NGTE+ LE   R+
Sbjct: 17  LSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRY 76

Query: 89  QLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEG 148
            L+ G  +I NP++A+D+G YQCLA+N VG+++SREA L+F +L  FS   R  V   EG
Sbjct: 77  SLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREG 136

Query: 149 WGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208
            GV+L C+PP H P + Y W+ NEFP+F+  D R F+SQ TGNLYI++   SD+G+Y CL
Sbjct: 137 QGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICL 196

Query: 209 ATSHMDFSTKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNP 267
             + +  +   V S    L L  +     + P I+  FP    A  G  V +ECFA GNP
Sbjct: 197 VKNTV--TNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNP 254

Query: 268 VPRIKWRKVDGSL--SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQA 325
           VP I W KV+G +    +   ++  L+IP+V  +D G YEC AENS+G+++ +G++ V  
Sbjct: 255 VPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYT 314

Query: 326 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385
            P W++ ++DT+ D GS LRW C A GKPRPT RWL+NG PL+ Q+RVE++ G L    +
Sbjct: 315 YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNV 374

Query: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAA 445
           +  D+GMYQC+AENK+G IYASAEL + A AP F LN +++ I   +  E++I C+P+ +
Sbjct: 375 NQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGS 434

Query: 446 PKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSV 505
           PK  + W KG   +  + R+ + PDG+L I N S+SDEGKY C  EN  G A     LSV
Sbjct: 435 PKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSV 494

Query: 506 RDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNV 565
           ++ T+I L P   ++ +G+++ L C A HD ++D+TF WTL   PIDF++ GGH+     
Sbjct: 495 KEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRA 554

Query: 566 KETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQ 625
           + +  DL I N  L H G+Y C  QT  DS S EA +LVRGPPGPPG V+V +I ++T  
Sbjct: 555 QASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTAT 614

Query: 626 LSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRV 685
           LSWS   DNHSPI+ Y LQAR+P +  W+ V+T P  I G+ E+A  + L PW++YEFRV
Sbjct: 615 LSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 674

Query: 686 IASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFG 745
           +A+N +GTG+PS PS  IRT EA P  AP+ +SG  G   EL++ W P+S E+QNG+GFG
Sbjct: 675 VATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG 734

Query: 746 YLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALV 805
           Y+++FR  G+  W+   V  ++A  F+Y +ESV P TPFEVK+  YN +GDGP S   ++
Sbjct: 735 YIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVI 794

Query: 806 YSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVR 865
            SAE EP  APT V A  VS SE+ V W+ +++ + G   G+E+ YWK  ++E  A+ V+
Sbjct: 795 CSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL-GRPQGFEVGYWKDMEQEDTAETVK 853

Query: 866 TAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSS 925
           T G ++   ++GL  NT YH TVRAYN AG GP S   +ATT K PP + P N+ W    
Sbjct: 854 TRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQG 913

Query: 926 SSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIR 985
           S +S+ W+PV+P  NES V GYK+ Y+ + H    +  T K    +P+P D G  ++++R
Sbjct: 914 SQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLP-DAGVYIIEVR 972

Query: 986 TTGPGGDG 993
               GGDG
Sbjct: 973 AYSEGGDG 980



 Score =  110 bits (276), Expect = 5e-24
 Identities = 211/908 (23%), Positives = 324/908 (35%), Gaps = 128/908 (14%)

Query: 57  VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVG--GNLVIMNPTKAQDAGVYQCLAS 114
           VL+      SP   Y W  N     +   SR  +    GNL I +  +  D G Y CL  
Sbjct: 140 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYI-SKVQTSDVGSYICLVK 198

Query: 115 NPV--GTVVSREAILRF---GFLQEFSK--EERDP--VKAHEGWGVMLPCNPPAHYPGLS 165
           N V    V+S    L     G + E+    E   P  V A +G  V + C    + P  +
Sbjct: 199 NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN-PVPT 257

Query: 166 YRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM---DFSTKSVFS 222
             W+  +   +IP+  R   SQ    L I      D G Y C A +      F  +    
Sbjct: 258 ITWM--KVNGYIPSKARLRKSQAV--LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 313

Query: 223 KFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP 282
            +        DT+L +               G  +  EC A G P P  +W K    LSP
Sbjct: 314 TYPHWVEKLNDTQLDS---------------GSPLRWECKATGKPRPTYRWLKNGVPLSP 358

Query: 283 QWTT--AEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP---------EWLK 331
           Q         L I +V+  D G Y+C AEN  G       + + A           + + 
Sbjct: 359 QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 418

Query: 332 VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLEDS 390
           V  D E  I       C   G P+PT+ W +    +    R+ +L  G LR    S  D 
Sbjct: 419 VTKDQEVVIE------CKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDE 472

Query: 391 GMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP--RAAPKA 448
           G Y C  EN  G+    A L+V+       L P R  +    G  I++ C+    A+   
Sbjct: 473 GKYVCRGENVFGSAEIIASLSVKE-PTRIELTPKRTELTV--GESIVLNCKAIHDASLDV 529

Query: 449 VVLWS-KGTEILVNS------SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501
              W+ KG  I          S         L+IRNI     G+Y C  +      +   
Sbjct: 530 TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 589

Query: 502 ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR 561
            L VR        P    I + + +T       + T  L+++   D+       P   Y 
Sbjct: 590 ELLVRGP------PGPPGIVIVEEIT-------ESTATLSWSPAADNH-----SPISSYN 631

Query: 562 -RTNVKETIGDLTILNA-QLRHGGKYTCMAQTVVDSASKEATVLVRGPPGP--------- 610
            +     ++G  T+    ++  G   + MA  +      E  V+   P G          
Sbjct: 632 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRM 691

Query: 611 -----------PGGVVVRDIGDTTIQLSW---SRGFDNHSPIAKYTLQARTPPAGKWKQV 656
                      P  V  R      + ++W   S  F N      Y +  R      WK+ 
Sbjct: 692 IRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG-YIVAFRPNGTRGWKEK 750

Query: 657 RTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSG 716
               +  E +    +   + P   +E +V   N  G G P      I + E  PS AP+ 
Sbjct: 751 MVTSS--EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PFSQIVVICSAEGEPSAAPTD 807

Query: 717 LSGGGGAPGELIVNWTPMSREYQNGDGF--GYLLSFRRQGSTHWQTARVPGADAQYFVYS 774
           +     +  E++V W  +        GF  GY     ++ +   +T +  G ++   +  
Sbjct: 808 VKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTA--ETVKTRGNESFVILTG 865

Query: 775 NESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV-WAKGVSSSEMNVTW 833
            E     T +   +R+YN  G GP S      + +  P  AP+ + W +    S++++ W
Sbjct: 866 LEG---NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ--QGSQVSLGW 920

Query: 834 EPVQQDMN-GILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYN 892
           EPV    N   ++GY++ Y + G   +    + T  L     V  L     Y + VRAY+
Sbjct: 921 EPVIPLANESEVVGYKVFYRQEGHSNSQV--IETQKLQA---VVPLPDAGVYIIEVRAYS 975

Query: 893 RAGTGPAS 900
             G G AS
Sbjct: 976 EGGDGTAS 983


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  899 bits (2323), Expect = 0.0
 Identities = 439/969 (45%), Positives = 616/969 (63%), Gaps = 13/969 (1%)

Query: 36  GPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNL 95
           GPVF  +P + +FP  S ++++ L C AR +P   YRW++NG+++ +    R++L GGNL
Sbjct: 25  GPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNL 84

Query: 96  VIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPC 155
           V++NP +  D G YQC A+N +GT+VSREA L+F +L+ F  + R  V   EG GV+L C
Sbjct: 85  VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC 144

Query: 156 NPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDF 215
            PP H   LSY W+ NE+P+F+  D R FVSQ TG+LYI++   SD+GNY+C+ TS +  
Sbjct: 145 GPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMV-- 202

Query: 216 STKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWR 274
           +   V      L L ++     + P I+ +FP    A  G  V LECFA GNP+P+I WR
Sbjct: 203 TNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWR 262

Query: 275 KVDG---SLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLK 331
           + DG   S   +       L+IP+   ED G+YEC AENS+G++  +GR+   A+P W++
Sbjct: 263 RSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQ 322

Query: 332 VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSG 391
           +I D E  +  +L W C A+GKP+P+ RWL+NG  L  + R ++  G L  S LS+ DSG
Sbjct: 323 LIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSG 382

Query: 392 MYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVL 451
           M+QC+AENKHG +Y+SAEL V A APDF  NP+++L+    G  + + C+PRA+P+A+  
Sbjct: 383 MFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSS 442

Query: 452 WSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKI 511
           W KG   +    R+++  DG L I N++++D G YTC AEN  GKAN T  L V + T+I
Sbjct: 443 WKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRI 502

Query: 512 TLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGD 571
           TLAPS+ D+++G+++ L C   HDP +D+ FTW  +    DF K G H+ +     + GD
Sbjct: 503 TLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSS-GD 561

Query: 572 LTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRG 631
           L I N QL+H GKY CM QT VDS S  A ++VRG PGPP  V V +I DTT QLSW  G
Sbjct: 562 LMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEG 621

Query: 632 FDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNIL 691
            DNHSP+  Y++QARTP +  W+ V T P  I+G   TA V+ L PW++YEFRV+ASN +
Sbjct: 622 KDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKI 681

Query: 692 GTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFR 751
           G GEPS PS K+RT EA P V PS ++GGGG+  EL++ W P+  E QNG+GFGY+++FR
Sbjct: 682 GGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFR 741

Query: 752 RQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE 811
             G T W    V   D   +V+ NES+ PY+P+EVK+  YN +G+GP S    V+SAEEE
Sbjct: 742 PLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEE 801

Query: 812 PRVAPTKVWAKGVSSSEMNVTWEPVQQDM-NGILLGYEIRYWKAGDKEAAADRVRTAGLD 870
           P VAP++V A  +SSSE+ V+W  +   + NG LLGYE+RYW  G KE ++ +++ AG +
Sbjct: 802 PTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNE 861

Query: 871 TSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSI 930
           TSAR+ GL  N  Y+  VRAYN AG GP S + N TT K PP +PPGN+ W  + + + +
Sbjct: 862 TSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLL 921

Query: 931 KWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIE--IPVPEDIGHALVQIRTTG 988
            W+ V    NES VTGYK+ Y+        +  T K   E  +P+ ED    +++++ T 
Sbjct: 922 NWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDY---IIEVKATT 978

Query: 989 PGGDGIPAE 997
            GGDG  +E
Sbjct: 979 DGGDGTSSE 987


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  898 bits (2321), Expect = 0.0
 Identities = 435/962 (45%), Positives = 613/962 (63%), Gaps = 7/962 (0%)

Query: 35   FGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGN 94
            +GPVF  +P  ++FP +S E++V L C  R +P  +YRW  NGTE+ LE   R+ L+ G 
Sbjct: 97   YGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGT 156

Query: 95   LVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLP 154
             +I NP++A+D+G YQCLA+N VG+++SREA L+F +L  FS   R  V   EG GV+L 
Sbjct: 157  FIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLM 216

Query: 155  CNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMD 214
            C+PP H P + Y W+ NEFP+F+  D R F+SQ TGNLYI++   SD+G+Y CL  + + 
Sbjct: 217  CSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTV- 275

Query: 215  FSTKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273
             +   V S    L L  +     + P I+  FP    A  G  V +ECFA GNPVP I W
Sbjct: 276  -TNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW 334

Query: 274  RKVDGSL--SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLK 331
             KV+G +    +   ++  L+IP+V  +D G YEC AENS+G+++ +G++ V   P W++
Sbjct: 335  MKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVE 394

Query: 332  VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSG 391
             ++DT+ D GS LRW C A GKPRPT RWL+NG PL+ Q+RVE++ G L    ++  D+G
Sbjct: 395  KLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAG 454

Query: 392  MYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVL 451
            MYQC+AENK+G IYASAEL + A AP F LN +++ I   +  E++I C+P+ +PK  + 
Sbjct: 455  MYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTIS 514

Query: 452  WSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKI 511
            W KG   +  + R+ + PDG+L I N S+SDEGKY C  EN  G A     LSV++ T+I
Sbjct: 515  WKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRI 574

Query: 512  TLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGD 571
             L P   ++ +G+++ L C A HD ++D+TF WTL   PIDF++ GGH+     + +  D
Sbjct: 575  ELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSAD 634

Query: 572  LTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRG 631
            L I N  L H G+Y C  QT  DS S EA +LVRGPPGPPG V+V +I ++T  LSWS  
Sbjct: 635  LMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPA 694

Query: 632  FDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNIL 691
             DNHSPI+ Y LQAR+P +  W+ V+T P  I G+ E+A  + L PW++YEFRV+A+N +
Sbjct: 695  ADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPI 754

Query: 692  GTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFR 751
            GTG+PS PS  IRT EA P  AP+ +SG  G   EL++ W P+S E+QNG+GFGY+++FR
Sbjct: 755  GTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFR 814

Query: 752  RQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE 811
              G+  W+   V  ++A  F+Y +ESV P TPFEVK+  YN +GDGP S   ++ SAE E
Sbjct: 815  PNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE 874

Query: 812  PRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDT 871
            P  APT V A  VS SE+ V W+ +++ + G   G+E+ YWK  ++E  A+ V+T G ++
Sbjct: 875  PSAAPTDVKATSVSVSEILVAWKHIKESL-GRPQGFEVGYWKDMEQEDTAETVKTRGNES 933

Query: 872  SARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIK 931
               ++GL  NT YH TVRAYN AG GP S   +ATT K PP + P N+ W    S +S+ 
Sbjct: 934  FVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLG 993

Query: 932  WDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGG 991
            W+PV+P  NES V GYK+ Y+ + H    +  T K    +P+P D G  ++++R    GG
Sbjct: 994  WEPVIPLANESEVVGYKVFYRQEGHSNSQVIETQKLQAVVPLP-DAGVYIIEVRAYSEGG 1052

Query: 992  DG 993
            DG
Sbjct: 1053 DG 1054



 Score =  110 bits (276), Expect = 5e-24
 Identities = 211/908 (23%), Positives = 324/908 (35%), Gaps = 128/908 (14%)

Query: 57   VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVG--GNLVIMNPTKAQDAGVYQCLAS 114
            VL+      SP   Y W  N     +   SR  +    GNL I +  +  D G Y CL  
Sbjct: 214  VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYI-SKVQTSDVGSYICLVK 272

Query: 115  NPV--GTVVSREAILRF---GFLQEFSK--EERDP--VKAHEGWGVMLPCNPPAHYPGLS 165
            N V    V+S    L     G + E+    E   P  V A +G  V + C    + P  +
Sbjct: 273  NTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN-PVPT 331

Query: 166  YRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM---DFSTKSVFS 222
              W+  +   +IP+  R   SQ    L I      D G Y C A +      F  +    
Sbjct: 332  ITWM--KVNGYIPSKARLRKSQAV--LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387

Query: 223  KFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP 282
             +        DT+L +               G  +  EC A G P P  +W K    LSP
Sbjct: 388  TYPHWVEKLNDTQLDS---------------GSPLRWECKATGKPRPTYRWLKNGVPLSP 432

Query: 283  QWTT--AEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP---------EWLK 331
            Q         L I +V+  D G Y+C AEN  G       + + A           + + 
Sbjct: 433  QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTII 492

Query: 332  VISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLEDS 390
            V  D E  I       C   G P+PT+ W +    +    R+ +L  G LR    S  D 
Sbjct: 493  VTKDQEVVIE------CKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDE 546

Query: 391  GMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP--RAAPKA 448
            G Y C  EN  G+    A L+V+       L P R  +    G  I++ C+    A+   
Sbjct: 547  GKYVCRGENVFGSAEIIASLSVKE-PTRIELTPKRTELTV--GESIVLNCKAIHDASLDV 603

Query: 449  VVLWS-KGTEILVNS------SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501
               W+ KG  I          S         L+IRNI     G+Y C  +      +   
Sbjct: 604  TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 663

Query: 502  ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR 561
             L VR        P    I + + +T       + T  L+++   D+       P   Y 
Sbjct: 664  ELLVRGP------PGPPGIVIVEEIT-------ESTATLSWSPAADNH-----SPISSYN 705

Query: 562  -RTNVKETIGDLTILNA-QLRHGGKYTCMAQTVVDSASKEATVLVRGPPGP--------- 610
             +     ++G  T+    ++  G   + MA  +      E  V+   P G          
Sbjct: 706  LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRM 765

Query: 611  -----------PGGVVVRDIGDTTIQLSW---SRGFDNHSPIAKYTLQARTPPAGKWKQV 656
                       P  V  R      + ++W   S  F N      Y +  R      WK+ 
Sbjct: 766  IRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFG-YIVAFRPNGTRGWKEK 824

Query: 657  RTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSG 716
                +  E +    +   + P   +E +V   N  G G P      I + E  PS AP+ 
Sbjct: 825  MVTSS--EASKFIYRDESVPPLTPFEVKVGVYNNKGDG-PFSQIVVICSAEGEPSAAPTD 881

Query: 717  LSGGGGAPGELIVNWTPMSREYQNGDGF--GYLLSFRRQGSTHWQTARVPGADAQYFVYS 774
            +     +  E++V W  +        GF  GY     ++ +   +T +  G ++   +  
Sbjct: 882  VKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTA--ETVKTRGNESFVILTG 939

Query: 775  NESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV-WAKGVSSSEMNVTW 833
             E     T +   +R+YN  G GP S      + +  P  AP+ + W +    S++++ W
Sbjct: 940  LEG---NTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQ--QGSQVSLGW 994

Query: 834  EPVQQDMN-GILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYN 892
            EPV    N   ++GY++ Y + G   +    + T  L     V  L     Y + VRAY+
Sbjct: 995  EPVIPLANESEVVGYKVFYRQEGHSNSQV--IETQKLQA---VVPLPDAGVYIIEVRAYS 1049

Query: 893  RAGTGPAS 900
              G G AS
Sbjct: 1050 EGGDGTAS 1057


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  897 bits (2319), Expect = 0.0
 Identities = 431/969 (44%), Positives = 617/969 (63%), Gaps = 9/969 (0%)

Query: 33  TTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVG 92
           T  GP+F  +P  V+FP +S E++V L C  + +P    RWK+NGT++      R+ +V 
Sbjct: 22  TLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE 81

Query: 93  GNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVM 152
           G+L+I NP K QDAG YQC A+N  GT+VSREA L+F +L  F    R  V    G G++
Sbjct: 82  GSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMV 141

Query: 153 LPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSH 212
           L C PP H   LSY W+ NE+P++   D R FVSQ TGNLYIA+   SD+GNY+C+ T+ 
Sbjct: 142 LLCGPPPHSGELSYAWIFNEYPSY--QDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNT 199

Query: 213 MDFSTKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRI 271
           +  +   V      L L  +     + P I+ +FP       G  V LECFA GNPVP I
Sbjct: 200 V--TNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257

Query: 272 KWRKVDG---SLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPE 328
            WR+ DG   +   +   +   L+IP+   ED G YEC AENS+G++  +G++   AQP 
Sbjct: 258 IWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPN 317

Query: 329 WLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLE 388
           W++ I+D    +  N+ W C A G+P+PT +WL+NGEPL +++R+++  G L  + ++L 
Sbjct: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLS 377

Query: 389 DSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKA 448
           D+GMYQC+AENKHG I+++AEL+V A+ PDF    ++R+     GGE++I C+P+A+PK 
Sbjct: 378 DAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKP 437

Query: 449 VVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDA 508
           V  W KG +IL  + R+T++ DG L I N+++SD G YTC A N  G A+STG L V+D 
Sbjct: 438 VYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDP 497

Query: 509 TKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKET 568
           T++ + PSS D+ +G+++ L C  +HD ++D+ FTW+ +   IDFD+ G H+ R   +++
Sbjct: 498 TRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDS 557

Query: 569 IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSW 628
            GDL I N QL+H GKY CM QT VD  S  A ++VRGPPGPP  V + +I DTT QLSW
Sbjct: 558 AGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSW 617

Query: 629 SRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIAS 688
             G DNHSPI  Y +QARTP +  W+ V T P  I+G   TA V+GL PW++YEFR +A+
Sbjct: 618 RPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAA 677

Query: 689 NILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLL 748
           N++G GEPS PS K RT EA P V P+ +SGGGG+  EL++ W  +  E QNG GFGY++
Sbjct: 678 NVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVV 737

Query: 749 SFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSA 808
           +FR  G   W    +  ADA  +V+ NESV P++PFEVK+  +N +G+GP S T +VYSA
Sbjct: 738 AFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSA 797

Query: 809 EEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAG 868
           EEEP   P  ++A+ +S++++ V W    +   G + GYE++YW+  DKE  A ++RT G
Sbjct: 798 EEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVG 857

Query: 869 LDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSL 928
             TS +++ L  +  YH+ V+AYN AGTGP+S + N TT KPPP +PPGNI W  S S +
Sbjct: 858 NQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKI 917

Query: 929 SIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTG 988
            + WD V    NES V GYK+LY+ +   + ++  T K  +E+ +P D  + +++I+   
Sbjct: 918 ILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDY-IIEIKPFS 976

Query: 989 PGGDGIPAE 997
            GGDG  +E
Sbjct: 977 DGGDGSSSE 985


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score =  857 bits (2213), Expect = 0.0
 Identities = 437/1003 (43%), Positives = 608/1003 (60%), Gaps = 40/1003 (3%)

Query: 13  LVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYR 72
           LV  + L++SSA    L       P+F  +P  V+FP + ++ +V+L C A   P   YR
Sbjct: 7   LVILLPLINSSAGDGLLSR-----PIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYR 61

Query: 73  WKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFL 132
           WK NGT++       ++L GG+L I +P   QD G+YQCLA+N +GT++SR+A L+F ++
Sbjct: 62  WKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYI 121

Query: 133 QEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNL 192
           ++F  + R  V   EG GV+L C PP H+  LSY W  N+ P ++  D R FVSQ TGNL
Sbjct: 122 EDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNL 181

Query: 193 YIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRL----------FAPSIK 242
           YIA+   SD+GNY+C  T+           K AQ ++    T L          + P I+
Sbjct: 182 YIAKVEPSDVGNYTCFITN-----------KEAQRSVQGPPTPLVQRTDGVMGEYEPKIE 230

Query: 243 ARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP---QWTTAEPTLQIPSVSFE 299
            RFP    A     V LECFA GNPVP I WR++DGS  P   +++ ++  L+IP+   E
Sbjct: 231 VRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQE 290

Query: 300 DEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVR 359
           DEG YEC A N +GR+  +G++I  A PEW + I +T   I  NL W C A+GKP P   
Sbjct: 291 DEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYT 350

Query: 360 WLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDF 419
           WL+NGE L  + R+++  G L  + L++ DSG+YQC AENK+  IYA+AEL V A APDF
Sbjct: 351 WLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDF 410

Query: 420 RLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNIS 479
             +PV++      GG+I+I C+P A P+A + W +GTE L  S R+ +  DG+L I NI+
Sbjct: 411 SKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNIT 470

Query: 480 RSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMD 539
           RSD G YTC A N  G A +TG L V++ T IT+ PS  D+ +G+++ L C  SHDP+++
Sbjct: 471 RSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIE 530

Query: 540 LTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKE 599
           + F W  +   ID  K   H+ R    E++GDL I N QL H GKY C  QT ++S S  
Sbjct: 531 VVFVWFFNGDVIDLKKGVAHFERIG-GESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAV 589

Query: 600 ATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTN 659
           A ++VRGPPGPP  V V DI  TT QLSW  G DN+SPI  +T+Q RTP +  W+ V T 
Sbjct: 590 ADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATV 649

Query: 660 PANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSG 719
           P  + G    A V+GL+PW++YEFRV+A N +G GEPS PS  +RT+ + P VAP  + G
Sbjct: 650 PEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHG 709

Query: 720 GGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVR 779
           GGG+  EL++ W  +  E QNG+GFGY++ FR  GST W   +V   ++  FVY NES+ 
Sbjct: 710 GGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESII 769

Query: 780 PYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQD 839
           P +PFEVK+  YN  G+G  S   +VYS E+EP++AP     +  S+SEM V+W  +  +
Sbjct: 770 PLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWN 829

Query: 840 MN-GILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGP 898
            N G +LGYE+ YW    KE+   ++R +G  T+  ++GL  NT Y  +VRAYN AGTGP
Sbjct: 830 RNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGP 889

Query: 899 ASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY----QND 954
           +SP  N TT K PP +PP NI+W  ++S L + W+ V    NES V GYK+LY    Q+ 
Sbjct: 890 SSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSK 949

Query: 955 LHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAE 997
            H+  T + + +  + +P  ED    L++IRT   GGDG  +E
Sbjct: 950 THILETNNTSAE--LLVPFEEDY---LIEIRTVSDGGDGSSSE 987


>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
          Length = 698

 Score =  653 bits (1685), Expect = 0.0
 Identities = 302/655 (46%), Positives = 436/655 (66%), Gaps = 1/655 (0%)

Query: 343 NLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHG 402
           N+ W C A G+P+PT +WL+NGEPL +++R+++  G L  + ++L D+GMYQC+AENKHG
Sbjct: 4   NVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHG 63

Query: 403 TIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNS 462
            I+++AEL+V A+ PDF    ++R+     GGE++I C+P+A+PK V  W KG +IL  +
Sbjct: 64  VIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN 123

Query: 463 SRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINL 522
            R+T++ DG L I N+++SD G YTC A N  G A+STG L V+D T++ + PSS D+ +
Sbjct: 124 ERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTV 183

Query: 523 GDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHG 582
           G+++ L C  +HD ++D+ FTW+ +   IDFD+ G H+ R   +++ GDL I N QL+H 
Sbjct: 184 GESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHA 243

Query: 583 GKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYT 642
           GKY CM QT VD  S  A ++VRGPPGPP  V + +I DTT QLSW  G DNHSPI  Y 
Sbjct: 244 GKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV 303

Query: 643 LQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSK 702
           +QARTP +  W+ V T P  I+G   TA V+GL PW++YEFR +A+N++G GEPS PS K
Sbjct: 304 IQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEK 363

Query: 703 IRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTAR 762
            RT EA P V P+ +SGGGG+  EL++ W  +  E QNG GFGY+++FR  G   W    
Sbjct: 364 RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTV 423

Query: 763 VPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAK 822
           +  ADA  +V+ NESV P++PFEVK+  +N +G+GP S T +VYSAEEEP   P  ++A+
Sbjct: 424 LASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFAR 483

Query: 823 GVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNT 882
            +S++++ V W    +   G + GYE++YW+  DKE  A ++RT G  TS +++ L  + 
Sbjct: 484 SLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSV 543

Query: 883 KYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNES 942
            YH+ V+AYN AGTGP+S + N TT KPPP +PPGNI W  S S + + WD V    NES
Sbjct: 544 LYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNES 603

Query: 943 AVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAE 997
            V GYK+LY+ +   + ++  T K  +E+ +P D  + +++I+    GGDG  +E
Sbjct: 604 EVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDY-IIEIKPFSDGGDGSSSE 657



 Score =  101 bits (252), Expect = 3e-21
 Identities = 146/681 (21%), Positives = 266/681 (39%), Gaps = 62/681 (9%)

Query: 255 QQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAEPTLQIPSVSFEDEGTYECEAENSK 312
           + V  EC A G P P  KW K    L    +    + TL I  V+  D G Y+C AEN  
Sbjct: 3   ENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKH 62

Query: 313 GRDTVQGRI-IVQAQPEWLKVISD--TEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLAS 369
           G       + ++   P++ + +    T   +G  +   C     P+P   W +  + L  
Sbjct: 63  GVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKE 122

Query: 370 QNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLI 428
             R+ +   G+LR   ++  D+G Y C+A N  GT  ++  L V+        +P R ++
Sbjct: 123 NERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVK--------DPTRVMV 174

Query: 429 PAAR-----GGEILIPCQPR--AAPKAVVLWSKGTEIL------VNSSRVTVTPD-GTLI 474
           P +      G  I++PCQ     +   V  WS    ++       +  RV      G L+
Sbjct: 175 PPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLM 234

Query: 475 IRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASH 534
           IRNI     GKY C  +  + + ++   L VR        P +  I+   + T Q     
Sbjct: 235 IRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG---PPEAVTIDEITDTTAQLSWRP 291

Query: 535 DPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTI------LNAQLRHGGKYTCM 588
            P      T  +      F    G    + V E I   T       LN  + +  ++  +
Sbjct: 292 GPDNHSPITMYVIQARTPFSV--GWQAVSTVPELIDGKTFTATVVGLNPWVEY--EFRTV 347

Query: 589 AQTVV-----DSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTL 643
           A  V+        S++       P   P  V       + + ++W    +       +  
Sbjct: 348 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGY 407

Query: 644 QARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKI 703
                P GK   + T  A+ + +    +   + P+  +E +V   N  G G P  P++ +
Sbjct: 408 VVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEG-PFSPTTVV 466

Query: 704 RTREAAPSVAPSGLSGGGGAPGELIVNW-TPMSREYQNGDGFGYLLSFRRQGSTHWQTAR 762
            + E  P+  P+ +     +  ++ V W +P+  E   G   GY + + R         +
Sbjct: 467 YSAEEEPTKPPASIFARSLSATDIEVFWASPL--EKNRGRIQGYEVKYWRHEDKEENARK 524

Query: 763 VPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTK-VWA 821
           +     Q       +++    + + +++YN  G GP S T  V + +  P   P   +W 
Sbjct: 525 IRTVGNQTST-KITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIW- 582

Query: 822 KGVSSSEMNVTWEPVQQ-DMNGILLGYEIRY-WKAGDKEAAADRVRTAGLDTSARVSGLH 879
              S S++ + W+ V+  D    + GY++ Y W   +++++   + T    TS  +S L 
Sbjct: 583 -NSSDSKIILNWDQVKALDNESEVKGYKVLYRW---NRQSSTSVIETN--KTSVELS-LP 635

Query: 880 PNTKYHVTVRAYNRAGTGPAS 900
            +  Y + ++ ++  G G +S
Sbjct: 636 FDEDYIIEIKPFSDGGDGSSS 656



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 84/311 (27%), Positives = 128/311 (41%), Gaps = 41/311 (13%)

Query: 54  EEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGG--NLVIMNPTKAQDAGVYQC 111
           EE V   C+A   P  TY+W  NG  +      R Q+  G  N+ I+N     DAG+YQC
Sbjct: 2   EENVFWECKANGRPKPTYKWLKNGEPLLTR--DRIQIEQGTLNITIVN---LSDAGMYQC 56

Query: 112 LASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHE-GWGVMLPCNPPAHYPGLSYRWLL 170
           LA N  G + S   +       +FS+     V   + G  V++ C P A  P   Y W  
Sbjct: 57  LAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKAS-PKPVYTWKK 115

Query: 171 NEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLA 230
               + +  + R  +S+  GNL I     SD G+Y+C+AT+H  F T S     +  NL 
Sbjct: 116 GR--DILKENERITISED-GNLRIINVTKSDAGSYTCIATNH--FGTAS-----STGNLV 165

Query: 231 AED-TRLFAPSIKARFPAETYALVGQQVTLEC-------------FAFGNPVPRIKWRKV 276
            +D TR+  P      P+     VG+ + L C             ++F   +     R  
Sbjct: 166 VKDPTRVMVP------PSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFD-RDG 218

Query: 277 DGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVIS-D 335
           D         +   L I ++  +  G Y C  + S  R +    +IV+  P   + ++ D
Sbjct: 219 DHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTID 278

Query: 336 TEADIGSNLRW 346
              D  + L W
Sbjct: 279 EITDTTAQLSW 289



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 69/265 (26%), Positives = 111/265 (41%), Gaps = 26/265 (9%)

Query: 162 PGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVF 221
           P  +Y+WL N  P  + T  R  + Q T N+ I   N SD G Y CLA +        +F
Sbjct: 15  PKPTYKWLKNGEP--LLTRDRIQIEQGTLNITIV--NLSDAGMYQCLAENKHGV----IF 66

Query: 222 SKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLS 281
           S  A+L++ A         +K      T   VG +V +EC    +P P   W+K    L 
Sbjct: 67  SN-AELSVIAVGPDFSRTLLKR----VTLVKVGGEVVIECKPKASPKPVYTWKKGRDILK 121

Query: 282 PQ---WTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEA 338
                  + +  L+I +V+  D G+Y C A N  G  +  G ++V+     +   S  + 
Sbjct: 122 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 181

Query: 339 DIGSNLRWGCAAAGKPRPTV--RWLRNGEPLASQ------NRV--EVLAGDLRFSKLSLE 388
            +G ++   C         +   W  NG  +          RV  +  AGDL    + L+
Sbjct: 182 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 241

Query: 389 DSGMYQCVAENKHGTIYASAELAVQ 413
            +G Y C+ +     + A+A+L V+
Sbjct: 242 HAGKYVCMVQTSVDRLSAAADLIVR 266


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
            [Homo sapiens]
          Length = 1224

 Score =  395 bits (1014), Expect = e-109
 Identities = 291/992 (29%), Positives = 458/992 (46%), Gaps = 90/992 (9%)

Query: 38   VFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNG-----TEMKLEPGSRHQLVG 92
            + +   + V FP    +E   + C A+ +P  T+ W  +G     T+ ++ P +      
Sbjct: 37   IIKQSKVQVAFP---FDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNN----S 89

Query: 93   GNLVIMNPTKAQD-AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGV 151
            G   I N        G Y+C ASN +G  +S E       + +F KE+ DP++  EG  +
Sbjct: 90   GTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPI 149

Query: 152  MLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGN-YSCLA- 209
            +LPCNPP   P L   W+  E  + I  D R ++SQ  G+LY A     D  N Y C A 
Sbjct: 150  VLPCNPPKGLPPLHIYWMNIELEH-IEQDERVYMSQK-GDLYFANVEEKDSRNDYCCFAA 207

Query: 210  -----TSHMDFSTKSVFSKFAQLNLAAEDTRLF--APSIKARFP------------AETY 250
                 T       K   +     N ++  T +   A SIK R P            +   
Sbjct: 208  FPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSIT 267

Query: 251  ALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAE---PTLQIPSVSFEDEGTYECE 307
             L G+ + LECFA G P P++ W K+ G L     T E    TL+I +VS++D+G Y C 
Sbjct: 268  ILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCT 327

Query: 308  AENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL 367
            A N  G  T    +IV+  P W K         GSN    C A G+P+PT++W  NG P+
Sbjct: 328  ASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPV 387

Query: 368  ASQNRVE--VLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVR 425
             +       V   ++ F+ L    + +YQC A N HGTI A+A + V  + P  +     
Sbjct: 388  DNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGE 447

Query: 426  RLIPAARGGEILIPCQPRAAPKAVVLWSKGTEIL-VNSSRVTVTPDGTLIIRNISRSDEG 484
                   G    + C+  A+P+AVV W K  E+  +   R  +  +GTL I   +  D G
Sbjct: 448  NYATVV-GYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAG 506

Query: 485  KYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTM--DLTF 542
             Y+C+ EN +GK   T  L +R+ATK+ ++P +  I     L L C +  D  +   L  
Sbjct: 507  SYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKL 566

Query: 543  TWTLDD--FPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEA 600
            +W+ D   F I+  + G       +     +LTI N  L   G Y C A T +DSA+   
Sbjct: 567  SWSKDGEAFEINGTEDG------RIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADIT 620

Query: 601  TVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQ--ARTPPAGKWKQVRT 658
             V V   P PP  + + +  + +++L+W  G D++S I++Y ++        G+W+++  
Sbjct: 621  QVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEEL-- 678

Query: 659  NPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLS 718
                ++G  +T  +L L P++ Y+FRVIA N +G  +PS PS    T  AAP   P  + 
Sbjct: 679  --TRVQGK-KTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIR 735

Query: 719  GGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGS-THWQTARVPGADAQYFVYSNES 777
                 P E+I+ W P+    QNG G  Y ++++ QG+   W+   V     +       +
Sbjct: 736  VQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVM-----T 790

Query: 778  VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ 837
               Y P++VK+++ N+ G GP+  +  +YS E+ P  AP       ++S+ + VTW  V 
Sbjct: 791  PAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVP 850

Query: 838  QD-MNGILLGYEIRYWKAGD------KEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRA 890
            +D ++G L GY+I +WK              + +R +G   S  V  L   +++H+TV A
Sbjct: 851  KDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLA 910

Query: 891  YNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKML 950
            YN  G GP S      T +  P +P           + ++ W   +P +    +TGY + 
Sbjct: 911  YNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWG--LPKKLNGNLTGYLLQ 968

Query: 951  YQ-----------NDLHLT----PTLHLTGKN 967
            YQ           ND+++T    P+ HL+  N
Sbjct: 969  YQIINDTYEIGELNDINITTPSKPSWHLSNLN 1000



 Score =  108 bits (269), Expect = 3e-23
 Identities = 176/772 (22%), Positives = 292/772 (37%), Gaps = 90/772 (11%)

Query: 181  GRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPS 240
            GR         L I   +  D GNY C A++ +  +T          ++  E+     P 
Sbjct: 300  GRETKENYGKTLKIENVSYQDKGNYRCTASNFLGTATHD-------FHVIVEE-----PP 347

Query: 241  IKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFED 300
               + P       G    L C A G P P IKWR V+GS       A   +    +SF +
Sbjct: 348  RWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWR-VNGSPVDNHPFAGDVVFPREISFTN 406

Query: 301  -----EGTYECEAENSKGRDTVQGRI-IVQAQPEWLKVISDTEADI-GSNLRWGCAAAGK 353
                    Y+CEA N  G       I +V  +P       +  A + G +    C     
Sbjct: 407  LQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFAS 466

Query: 354  PRPTVRWLRNGE--PLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELA 411
            P   V W +  E  PL  +       G L+ ++ + ED+G Y C  EN  G    +A L 
Sbjct: 467  PEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLD 526

Query: 412  VQALAPDFRLNPVRRLIPAARGGEILIP--CQPRAAPKAVVLWSKGTEILVNSSRVTVTP 469
            ++  A   R++P    IP     E+     C         + WSK  E       +  T 
Sbjct: 527  IRN-ATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAF----EINGTE 581

Query: 470  DGTLII-------RNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLA-----PSS 517
            DG +II        N++  D+G Y C A         T + S  D T++T+      P +
Sbjct: 582  DGRIIIDGANLTISNVTLEDQGIYCCSAH--------TALDSAADITQVTVLDVPDPPEN 633

Query: 518  ADINLGDN----LTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNV---KETIG 570
              ++   N    LT +  A H+  +         +F  + ++PG     T V   K T+ 
Sbjct: 634  LHLSERQNRSVRLTWEAGADHNSNISEYIV----EFEGNKEEPGRWEELTRVQGKKTTV- 688

Query: 571  DLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGP---PGGVVVRDIGDTTIQLS 627
             +  L   +R+  +   + +      S+ +      P  P   P  + V+      + + 
Sbjct: 689  -ILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIK 747

Query: 628  WS--RGFDNHSPIAKY--TLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEF 683
            W   +  + + P  +Y  T + +  P    ++  TN         T +V+    +  Y+ 
Sbjct: 748  WEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN--------HTLRVMTPAVYAPYDV 799

Query: 684  RVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELI-VNWTPMSREYQNGD 742
            +V A N LG+G P   S  + + E  P  AP  + G       L+ V W+ + ++  +G 
Sbjct: 800  KVQAINQLGSG-PDPQSVTLYSGEDYPDTAPV-IHGVDVINSTLVKVTWSTVPKDRVHGR 857

Query: 743  GFGYLLSFRR-----QGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDG 797
              GY +++ +      G TH +   +     Q       S+  ++ F + + +YN +G G
Sbjct: 858  LKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAG 917

Query: 798  PESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDK 857
            PES   +  + E  P   PT +    V      ++W  + + +NG L GY ++Y    D 
Sbjct: 918  PESEPYIFQTPEGVPE-QPTFLKVIKVDKDTATLSWG-LPKKLNGNLTGYLLQYQIINDT 975

Query: 858  EAAA---DRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANAT 906
                   D   T     S  +S L+  TKY   +RA    G G      ++T
Sbjct: 976  YEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESST 1027


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  386 bits (992), Expect = e-107
 Identities = 296/945 (31%), Positives = 430/945 (45%), Gaps = 74/945 (7%)

Query: 46  VLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLE----------PGSRHQLVGGNL 95
           V+FP +     + L C A   P   +RW  +G   K +          P S    + GN 
Sbjct: 41  VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGN- 95

Query: 96  VIMNPTKAQD-AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLP 154
              N   AQ   G+Y+C ASN +GT +S E  L      ++ KE   PV+  EG  V+LP
Sbjct: 96  ---NSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLP 152

Query: 155 CNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDL-GNYSCLATSHM 213
           CNPP     L   W+ ++  + I  D R  + Q  GNLY A    SD   +Y C    H 
Sbjct: 153 CNPPPSAEPLRIYWMNSKILH-IKQDERVTMGQN-GNLYFANVLTSDNHSDYIC----HA 206

Query: 214 DF-STKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAET----YALVGQQVTLECFAFGNP 267
            F  T+++  K   ++L  + T  +     +  FP  +     AL GQ + LEC A G P
Sbjct: 207 HFPGTRTIIQK-EPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 265

Query: 268 VPRIKWRKVDGSLSPQWTTAE---PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ 324
            P IKW +  G +     T +    TLQ+  V  ED+G Y C AENS G       + V+
Sbjct: 266 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 325

Query: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEP---LASQNRVEVLAGDLR 381
           A P WL          G   R  C   G+P+P V W  NG P   LA   +  +  G L 
Sbjct: 326 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALI 385

Query: 382 FSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ 441
            S +   D+ + QC A N+HG + A+A + V  L P   L    +   A +G    + C+
Sbjct: 386 LSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL-PAKILTADNQTYMAVQGSTAYLLCK 444

Query: 442 PRAAPKAVVLW--SKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANS 499
              AP   V W    GT +L    R     +GTL IR++  +D G+Y C A N       
Sbjct: 445 AFGAPVPSVQWLDEDGTTVL-QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTI 503

Query: 500 TGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGH 559
              L V+DAT+IT  P S     G  +T  C AS DP++  + TW  D   +        
Sbjct: 504 MANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDK 563

Query: 560 YRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRD- 618
           Y   +     G L I +      G Y+C+A T +D     A +LV G PGP   +V+ D 
Sbjct: 564 YFIED-----GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 618

Query: 619 --IGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAG--KWKQVRTNPANIEGNAETAQVLG 674
             +  + +++SWS   D+++PI KY ++         KW  +   P N     +T+  L 
Sbjct: 619 HLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN-----QTSTTLK 673

Query: 675 LTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPM 734
           L+P++ Y FRV A N  G GEPS  S  + T EAAP   P  + G G     +++ W P+
Sbjct: 674 LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPL 733

Query: 735 SREYQNGDGFGYLLSFRRQGST-HWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNR 793
                N     Y + +R QG+   WQ   V      + V SN S   + P+E+K+++ N 
Sbjct: 734 RWMDWNAPQVQYRVQWRPQGTRGPWQEQIV---SDPFLVVSNTST--FVPYEIKVQAVNS 788

Query: 794 RGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ-QDMNGILLGYEIRYW 852
           +G GPE    + YS E+ P+  P     + ++SS + V W PV    + G L GY + YW
Sbjct: 789 QGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYW 848

Query: 853 KAGDKEAAA------DRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANAT 906
           + G +   +      D V      TS  +SGL P + YH+ V+A+N  G+GPAS     +
Sbjct: 849 REGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFS 907

Query: 907 TMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           T +  P  P        S++SL ++W P  P  +   +TGY + Y
Sbjct: 908 TPEGVPGHPEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 950



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 80/379 (21%), Positives = 142/379 (37%), Gaps = 37/379 (9%)

Query: 239 PSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIP-SVS 297
           P I  + P          ++L+C A G P  + +W +      P+        Q P S S
Sbjct: 30  PVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGS 89

Query: 298 F-----------EDEGTYECEAENSKGRD-TVQGRIIVQAQPEWLK-VISDTEADIGSNL 344
           F             +G Y C A N  G   + + R++ +  P+W K  +   E + G ++
Sbjct: 90  FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESV 149

Query: 345 RWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA---GDLRFSK-LSLEDSGMYQCVAE-N 399
              C       P   +  N + L  +    V     G+L F+  L+ ++   Y C A   
Sbjct: 150 VLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFP 209

Query: 400 KHGTIYASAELAVQALAPDFRLNPVRRL---------IPAARGGEILIPCQPRAAPKAVV 450
              TI     + ++  A +  ++   RL         + A +G  +++ C     P   +
Sbjct: 210 GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI 269

Query: 451 LWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATK 510
            W + +  +          + TL +  +   D+G+Y C AEN +G A     ++V  A  
Sbjct: 270 KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 329

Query: 511 ITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR-------RT 563
               P S     G+   L C     P  ++  TW ++  P++       YR        +
Sbjct: 330 WLHKPQSHLYGPGETARLDCQVQGRPQPEV--TWRINGIPVEELAKDQKYRIQRGALILS 387

Query: 564 NVKETIGDLTILNAQLRHG 582
           NV+ +   +T   A+ RHG
Sbjct: 388 NVQPSDTMVTQCEARNRHG 406


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  386 bits (992), Expect = e-107
 Identities = 296/945 (31%), Positives = 430/945 (45%), Gaps = 74/945 (7%)

Query: 46  VLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLE----------PGSRHQLVGGNL 95
           V+FP +     + L C A   P   +RW  +G   K +          P S    + GN 
Sbjct: 46  VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGN- 100

Query: 96  VIMNPTKAQD-AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLP 154
              N   AQ   G+Y+C ASN +GT +S E  L      ++ KE   PV+  EG  V+LP
Sbjct: 101 ---NSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLP 157

Query: 155 CNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDL-GNYSCLATSHM 213
           CNPP     L   W+ ++  + I  D R  + Q  GNLY A    SD   +Y C    H 
Sbjct: 158 CNPPPSAEPLRIYWMNSKILH-IKQDERVTMGQN-GNLYFANVLTSDNHSDYIC----HA 211

Query: 214 DF-STKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAET----YALVGQQVTLECFAFGNP 267
            F  T+++  K   ++L  + T  +     +  FP  +     AL GQ + LEC A G P
Sbjct: 212 HFPGTRTIIQK-EPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270

Query: 268 VPRIKWRKVDGSLSPQWTTAE---PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ 324
            P IKW +  G +     T +    TLQ+  V  ED+G Y C AENS G       + V+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330

Query: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEP---LASQNRVEVLAGDLR 381
           A P WL          G   R  C   G+P+P V W  NG P   LA   +  +  G L 
Sbjct: 331 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALI 390

Query: 382 FSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ 441
            S +   D+ + QC A N+HG + A+A + V  L P   L    +   A +G    + C+
Sbjct: 391 LSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL-PAKILTADNQTYMAVQGSTAYLLCK 449

Query: 442 PRAAPKAVVLW--SKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANS 499
              AP   V W    GT +L    R     +GTL IR++  +D G+Y C A N       
Sbjct: 450 AFGAPVPSVQWLDEDGTTVL-QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTI 508

Query: 500 TGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGH 559
              L V+DAT+IT  P S     G  +T  C AS DP++  + TW  D   +        
Sbjct: 509 MANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDK 568

Query: 560 YRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRD- 618
           Y   +     G L I +      G Y+C+A T +D     A +LV G PGP   +V+ D 
Sbjct: 569 YFIED-----GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 623

Query: 619 --IGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAG--KWKQVRTNPANIEGNAETAQVLG 674
             +  + +++SWS   D+++PI KY ++         KW  +   P N     +T+  L 
Sbjct: 624 HLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN-----QTSTTLK 678

Query: 675 LTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPM 734
           L+P++ Y FRV A N  G GEPS  S  + T EAAP   P  + G G     +++ W P+
Sbjct: 679 LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPL 738

Query: 735 SREYQNGDGFGYLLSFRRQGST-HWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNR 793
                N     Y + +R QG+   WQ   V      + V SN S   + P+E+K+++ N 
Sbjct: 739 RWMDWNAPQVQYRVQWRPQGTRGPWQEQIV---SDPFLVVSNTST--FVPYEIKVQAVNS 793

Query: 794 RGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ-QDMNGILLGYEIRYW 852
           +G GPE    + YS E+ P+  P     + ++SS + V W PV    + G L GY + YW
Sbjct: 794 QGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYW 853

Query: 853 KAGDKEAAA------DRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANAT 906
           + G +   +      D V      TS  +SGL P + YH+ V+A+N  G+GPAS     +
Sbjct: 854 REGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFS 912

Query: 907 TMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           T +  P  P        S++SL ++W P  P  +   +TGY + Y
Sbjct: 913 TPEGVPGHPEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 955



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 80/379 (21%), Positives = 142/379 (37%), Gaps = 37/379 (9%)

Query: 239 PSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIP-SVS 297
           P I  + P          ++L+C A G P  + +W +      P+        Q P S S
Sbjct: 35  PVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGS 94

Query: 298 F-----------EDEGTYECEAENSKGRD-TVQGRIIVQAQPEWLK-VISDTEADIGSNL 344
           F             +G Y C A N  G   + + R++ +  P+W K  +   E + G ++
Sbjct: 95  FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESV 154

Query: 345 RWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA---GDLRFSK-LSLEDSGMYQCVAE-N 399
              C       P   +  N + L  +    V     G+L F+  L+ ++   Y C A   
Sbjct: 155 VLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFP 214

Query: 400 KHGTIYASAELAVQALAPDFRLNPVRRL---------IPAARGGEILIPCQPRAAPKAVV 450
              TI     + ++  A +  ++   RL         + A +G  +++ C     P   +
Sbjct: 215 GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI 274

Query: 451 LWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATK 510
            W + +  +          + TL +  +   D+G+Y C AEN +G A     ++V  A  
Sbjct: 275 KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 334

Query: 511 ITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR-------RT 563
               P S     G+   L C     P  ++  TW ++  P++       YR        +
Sbjct: 335 WLHKPQSHLYGPGETARLDCQVQGRPQPEV--TWRINGIPVEELAKDQKYRIQRGALILS 392

Query: 564 NVKETIGDLTILNAQLRHG 582
           NV+ +   +T   A+ RHG
Sbjct: 393 NVQPSDTMVTQCEARNRHG 411


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  386 bits (992), Expect = e-107
 Identities = 296/945 (31%), Positives = 430/945 (45%), Gaps = 74/945 (7%)

Query: 46  VLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLE----------PGSRHQLVGGNL 95
           V+FP +     + L C A   P   +RW  +G   K +          P S    + GN 
Sbjct: 46  VVFPTDD----ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGN- 100

Query: 96  VIMNPTKAQD-AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLP 154
              N   AQ   G+Y+C ASN +GT +S E  L      ++ KE   PV+  EG  V+LP
Sbjct: 101 ---NSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLP 157

Query: 155 CNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDL-GNYSCLATSHM 213
           CNPP     L   W+ ++  + I  D R  + Q  GNLY A    SD   +Y C    H 
Sbjct: 158 CNPPPSAEPLRIYWMNSKILH-IKQDERVTMGQN-GNLYFANVLTSDNHSDYIC----HA 211

Query: 214 DF-STKSVFSKFAQLNLAAEDTR-LFAPSIKARFPAET----YALVGQQVTLECFAFGNP 267
            F  T+++  K   ++L  + T  +     +  FP  +     AL GQ + LEC A G P
Sbjct: 212 HFPGTRTIIQK-EPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270

Query: 268 VPRIKWRKVDGSLSPQWTTAE---PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ 324
            P IKW +  G +     T +    TLQ+  V  ED+G Y C AENS G       + V+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330

Query: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEP---LASQNRVEVLAGDLR 381
           A P WL          G   R  C   G+P+P V W  NG P   LA   +  +  G L 
Sbjct: 331 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALI 390

Query: 382 FSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ 441
            S +   D+ + QC A N+HG + A+A + V  L P   L    +   A +G    + C+
Sbjct: 391 LSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL-PAKILTADNQTYMAVQGSTAYLLCK 449

Query: 442 PRAAPKAVVLW--SKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANS 499
              AP   V W    GT +L    R     +GTL IR++  +D G+Y C A N       
Sbjct: 450 AFGAPVPSVQWLDEDGTTVL-QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTI 508

Query: 500 TGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGH 559
              L V+DAT+IT  P S     G  +T  C AS DP++  + TW  D   +        
Sbjct: 509 MANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDK 568

Query: 560 YRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRD- 618
           Y   +     G L I +      G Y+C+A T +D     A +LV G PGP   +V+ D 
Sbjct: 569 YFIED-----GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDL 623

Query: 619 --IGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAG--KWKQVRTNPANIEGNAETAQVLG 674
             +  + +++SWS   D+++PI KY ++         KW  +   P N     +T+  L 
Sbjct: 624 HLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN-----QTSTTLK 678

Query: 675 LTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPM 734
           L+P++ Y FRV A N  G GEPS  S  + T EAAP   P  + G G     +++ W P+
Sbjct: 679 LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPL 738

Query: 735 SREYQNGDGFGYLLSFRRQGST-HWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNR 793
                N     Y + +R QG+   WQ   V      + V SN S   + P+E+K+++ N 
Sbjct: 739 RWMDWNAPQVQYRVQWRPQGTRGPWQEQIV---SDPFLVVSNTST--FVPYEIKVQAVNS 793

Query: 794 RGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ-QDMNGILLGYEIRYW 852
           +G GPE    + YS E+ P+  P     + ++SS + V W PV    + G L GY + YW
Sbjct: 794 QGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYW 853

Query: 853 KAGDKEAAA------DRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANAT 906
           + G +   +      D V      TS  +SGL P + YH+ V+A+N  G+GPAS     +
Sbjct: 854 REGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFTFS 912

Query: 907 TMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           T +  P  P        S++SL ++W P  P  +   +TGY + Y
Sbjct: 913 TPEGVPGHPEALHLECQSNTSLLLRWQP--PLSHNGVLTGYVLSY 955



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 80/379 (21%), Positives = 142/379 (37%), Gaps = 37/379 (9%)

Query: 239 PSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIP-SVS 297
           P I  + P          ++L+C A G P  + +W +      P+        Q P S S
Sbjct: 35  PVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGS 94

Query: 298 F-----------EDEGTYECEAENSKGRD-TVQGRIIVQAQPEWLK-VISDTEADIGSNL 344
           F             +G Y C A N  G   + + R++ +  P+W K  +   E + G ++
Sbjct: 95  FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESV 154

Query: 345 RWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA---GDLRFSK-LSLEDSGMYQCVAE-N 399
              C       P   +  N + L  +    V     G+L F+  L+ ++   Y C A   
Sbjct: 155 VLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFP 214

Query: 400 KHGTIYASAELAVQALAPDFRLNPVRRL---------IPAARGGEILIPCQPRAAPKAVV 450
              TI     + ++  A +  ++   RL         + A +G  +++ C     P   +
Sbjct: 215 GTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTI 274

Query: 451 LWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATK 510
            W + +  +          + TL +  +   D+G+Y C AEN +G A     ++V  A  
Sbjct: 275 KWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPY 334

Query: 511 ITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR-------RT 563
               P S     G+   L C     P  ++  TW ++  P++       YR        +
Sbjct: 335 WLHKPQSHLYGPGETARLDCQVQGRPQPEV--TWRINGIPVEELAKDQKYRIQRGALILS 392

Query: 564 NVKETIGDLTILNAQLRHG 582
           NV+ +   +T   A+ RHG
Sbjct: 393 NVQPSDTMVTQCEARNRHG 411


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score =  376 bits (965), Expect = e-104
 Identities = 284/941 (30%), Positives = 425/941 (45%), Gaps = 65/941 (6%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGN----LVIMNPTKAQD-AGVY 109
           E +++ C A+  PP ++ W  NGT   ++      +  G     + IM+  KA+   GVY
Sbjct: 56  ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVY 115

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  G  VS   ++R      ++KE+ +P+    G  ++LPC PP   P     W+
Sbjct: 116 QCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWM 175

Query: 170 LNEFPNFIPTDGRHFVSQ-TTGNLYIARTNASDLG-NYSCLATSH--------MDFSTKS 219
            N F   +P   R  VSQ   G+LY +     D   +Y C A  +           S K 
Sbjct: 176 DNSFQR-LPQSER--VSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 232

Query: 220 VFSKFAQLNLAAE--DTRLF-APSIKARFP---------AETYALVGQQVTLECFAFGNP 267
           +        +AA   DT  + A S + R P         +    L G  ++LEC A G P
Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292

Query: 268 VPRIKWRKVDGSLSPQWTTA---EPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ 324
            P I W K DG L    T     E TLQI  VS  D G Y+C A+N+ G       + V+
Sbjct: 293 TPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVK 352

Query: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL--ASQNRVEVLAGD-LR 381
           A P W+    +     G +    C A G P+P + WL NG P+  A  +    + GD + 
Sbjct: 353 AAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTII 412

Query: 382 FSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ 441
           FS +    S +YQC A N++G + A+A + V A  P   L P   L         L+ C 
Sbjct: 413 FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANTLYQVIANRPALLDCA 471

Query: 442 PRAAPKAVVLWSKGTE-ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANST 500
              +P   + W KG +   ++     +  +GTL I    +   G YTC A N +G A + 
Sbjct: 472 FFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNE 531

Query: 501 GILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHY 560
             L ++D T I   P  A +  G  ++ +C   HD T+ LT  W  D+  +  D+     
Sbjct: 532 VHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDE----- 586

Query: 561 RRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIG 620
           R T  K+    L + +      G YTC+A T +DS S  A + V   P PP  + + D  
Sbjct: 587 RFTVDKD---HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQL 643

Query: 621 DTTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIEGNAETAQVLGLTPW 678
           D ++QLSW+ G DN+SPI K+ ++        G W     +   + G   TAQ L L+P+
Sbjct: 644 DKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWH----HQTEVSGTQTTAQ-LKLSPY 698

Query: 679 MDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREY 738
           ++Y FRV+A N +G   PS  S +  T+ + P   P+ + G G  P  L++ W P++   
Sbjct: 699 VNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFE 758

Query: 739 QNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP 798
            NG G  Y +S+R++      T+ V    ++Y V    +   + P+ +K+++ N  G  P
Sbjct: 759 SNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPT---FVPYLIKVQALNDMGFAP 815

Query: 799 ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ-QDMNGILLGYEIRYWKAGDK 857
           E    + +S E+ P VAP  V    V+S+   V W+PV  + + G L GY I YWK    
Sbjct: 816 EPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSS 875

Query: 858 EAAADR------VRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPP 911
                R      +   G  T   + GL P + Y + VR  N  G GPASP     T +  
Sbjct: 876 SKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGV 935

Query: 912 PRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952
           P  P        +  SL+++WDP  P      +T Y + YQ
Sbjct: 936 PSAPSSLKIVNPTLDSLTLEWDP--PSHPNGILTEYTLKYQ 974



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 104/419 (24%), Positives = 163/419 (38%), Gaps = 60/419 (14%)

Query: 239 PSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRK------VDG----SLSPQWTTAE 288
           P+I  + P +      + + ++C A G P P   W +      +D     ++ P   T  
Sbjct: 40  PTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLI 99

Query: 289 PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ--AQPEWLK-VISDTEADIGSNLR 345
             +     +   EG Y+C A N +G   V   I+V+    P W K  +       G +L 
Sbjct: 100 INIMSEGKAETYEGVYQCTARNERGA-AVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 158

Query: 346 WGC-AAAGKPRPTVRWLRNG-EPLASQNRV-EVLAGDLRFSKLSLEDSGM-YQCVAENKH 401
             C    G P P + W+ N  + L    RV + L GDL FS +  ED+   Y C A   H
Sbjct: 159 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNH 218

Query: 402 -GTIYASAELAVQALAPD--------------------FRLNPVRRLIPAA--------R 432
             TI     ++V+ ++ D                     R  P   L P          R
Sbjct: 219 TQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELR 278

Query: 433 GGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAEN 492
           G  + + C     P  ++ W+K   +L  +  V    + TL I ++S +D G Y C A+N
Sbjct: 279 GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKN 338

Query: 493 FMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPID 552
            +G  + T  + V+ A     AP +  ++ G++ TL C A+ +P   +  +W  +  PI+
Sbjct: 339 ALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRI--SWLTNGVPIE 396

Query: 553 F--DKPGGHYRRTNVKETIGDLTIL-NAQLRHGGKYTCMAQTVVDSASKEATVLVRGPP 608
              D P         ++  GD  I  N Q R    Y C A          A V V   P
Sbjct: 397 IAPDDPS--------RKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEP 447



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 84/373 (22%), Positives = 137/373 (36%), Gaps = 78/373 (20%)

Query: 315 DTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPL 367
           D VQ   I Q  P+      D   D   N+   C A GKP P+  W RNG       +PL
Sbjct: 35  DLVQPPTITQQSPK------DYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPL 88

Query: 368 ASQN-RVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDF---RLNP 423
            +       L  ++     +    G+YQC A N+ G   ++  +   + +P +   +L P
Sbjct: 89  VTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEP 148

Query: 424 VRRLIPAARGGEILIPCQPR-AAPKAVVLWSKGT-EILVNSSRVTVTPDGTLIIRNISRS 481
               I    G  +++PC+P    P  ++ W   + + L  S RV+   +G L   N+   
Sbjct: 149 ----ITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPE 204

Query: 482 DEGK-YTCFAE-NFMGKANSTGILSVR----DATKITLAPSSADINL------------- 522
           D  + Y C+A  N          +SV+    D    T+A + +D                
Sbjct: 205 DTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF 264

Query: 523 --------------GDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKET 568
                         G+ L+L+C A   PT      W  +D  +          RT  K  
Sbjct: 265 LTPEGNASNKEELRGNVLSLECIAEGLPTP--IIYWAKEDGMLP-------KNRTVYKNF 315

Query: 569 IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRG-------------PPGPPGGVV 615
              L I++      G Y C+A+  + +     +V V+               PG  G ++
Sbjct: 316 EKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI 375

Query: 616 VRDIGDTTIQLSW 628
            R  G+   ++SW
Sbjct: 376 CRANGNPKPRISW 388



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 61/271 (22%), Positives = 105/271 (38%), Gaps = 33/271 (12%)

Query: 52  STEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQC 111
           S  E   L CRA  +P     W  NG  +++ P    + + G+ +I +  + + + VYQC
Sbjct: 367 SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQC 426

Query: 112 LASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPA-------HYPGL 164
            ASN  G +++        F+   ++  R    A+  + V+   N PA         P  
Sbjct: 427 NASNEYGYLLAN------AFVNVLAEPPRILTPANTLYQVI--ANRPALLDCAFFGSPLP 478

Query: 165 SYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKF 224
           +  W      + +  D   +V    G L I        G Y+C+A + +  +   V    
Sbjct: 479 TIEWFKGAKGSALHED--IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEV---- 532

Query: 225 AQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPV--PRIKWRKVDGSL-- 280
              +L  +D     P+   + P       G  V+ EC    +      + W K +  L  
Sbjct: 533 ---HLEIKD-----PTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPS 584

Query: 281 SPQWTTAEPTLQIPSVSFEDEGTYECEAENS 311
             ++T  +  L +  VS +D GTY C A  +
Sbjct: 585 DERFTVDKDHLVVADVSDDDSGTYTCVANTT 615


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score =  372 bits (954), Expect = e-102
 Identities = 285/951 (29%), Positives = 426/951 (44%), Gaps = 75/951 (7%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGN----LVIMNPTKAQD-AGVY 109
           E +++ C A+  PP ++ W  NGT   ++      +  G     + IM+  KA+   GVY
Sbjct: 62  ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVY 121

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  G  VS   ++R      ++KE+ +P+    G  ++LPC PP   P     W+
Sbjct: 122 QCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWM 181

Query: 170 LNEFPNFIPTDGRHFVSQ-TTGNLYIARTNASDLG-NYSCLATSH--------MDFSTKS 219
            N F   +P   R  VSQ   G+LY +     D   +Y C A  +           S K 
Sbjct: 182 DNSFQR-LPQSER--VSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 238

Query: 220 VFSKFAQLNLAAE--DTRLF-APSIKARFP---------AETYALVGQQVTLECFAFGNP 267
           +        +AA   DT  + A S + R P         +    L G  ++LEC A G P
Sbjct: 239 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 298

Query: 268 VPRIKWRKVDGSLSPQWTTA---EPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ 324
            P I W K DG L    T     E TLQI  VS  D G Y+C A+N+ G       + V+
Sbjct: 299 TPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVK 358

Query: 325 AQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL--ASQNRVEVLAGD-LR 381
           A P W+    +     G +    C A G P+P + WL NG P+  A  +    + GD + 
Sbjct: 359 AAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTII 418

Query: 382 FSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ 441
           FS +    S +YQC A N++G + A+A + V A  P   L P   L         L+ C 
Sbjct: 419 FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRI-LTPANTLYQVIANRPALLDCA 477

Query: 442 PRAAPKAVVLWSKGTE-ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANST 500
              +P   + W KG +   ++     +  +GTL I    +   G YTC A N +G A + 
Sbjct: 478 FFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNE 537

Query: 501 GILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHY 560
             L ++D T I   P  A +  G  ++ +C   HD T+ LT  W  D+  +  D+     
Sbjct: 538 VHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDE----- 592

Query: 561 RRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGP----------PGP 610
           R T  K+    L + +      G YTC+A T +DS S  A + V  P          P P
Sbjct: 593 RFTVDKD---HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNP 649

Query: 611 PGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIEGNAE 668
           P  + + D  D ++QLSW+ G DN+SPI K+ ++        G W     +   + G   
Sbjct: 650 PFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWH----HQTEVSGTQT 705

Query: 669 TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELI 728
           TAQ L L+P+++Y FRV+A N +G   PS  S +  T+ + P   P+ + G G  P  L+
Sbjct: 706 TAQ-LKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLV 764

Query: 729 VNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKI 788
           + W P++    NG G  Y +S+R++      T+ V    ++Y V    +   + P+ +K+
Sbjct: 765 ITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPT---FVPYLIKV 821

Query: 789 RSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ-QDMNGILLGY 847
           ++ N  G  PE    + +S E+ P VAP  V    V+S+   V W+PV  + + G L GY
Sbjct: 822 QALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGY 881

Query: 848 EIRYWKAGDKEAAADR------VRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASP 901
            I YWK         R      +   G  T   + GL P + Y + VR  N  G GPASP
Sbjct: 882 RIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASP 941

Query: 902 SANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952
                T +  P  P        +  SL+++WDP  P      +T Y + YQ
Sbjct: 942 DRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDP--PSHPNGILTEYTLKYQ 990



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 104/419 (24%), Positives = 163/419 (38%), Gaps = 60/419 (14%)

Query: 239 PSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRK------VDG----SLSPQWTTAE 288
           P+I  + P +      + + ++C A G P P   W +      +D     ++ P   T  
Sbjct: 46  PTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLI 105

Query: 289 PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQ--AQPEWLK-VISDTEADIGSNLR 345
             +     +   EG Y+C A N +G   V   I+V+    P W K  +       G +L 
Sbjct: 106 INIMSEGKAETYEGVYQCTARNERGA-AVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 164

Query: 346 WGC-AAAGKPRPTVRWLRNG-EPLASQNRV-EVLAGDLRFSKLSLEDSGM-YQCVAENKH 401
             C    G P P + W+ N  + L    RV + L GDL FS +  ED+   Y C A   H
Sbjct: 165 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNH 224

Query: 402 -GTIYASAELAVQALAPD--------------------FRLNPVRRLIPAA--------R 432
             TI     ++V+ ++ D                     R  P   L P          R
Sbjct: 225 TQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELR 284

Query: 433 GGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAEN 492
           G  + + C     P  ++ W+K   +L  +  V    + TL I ++S +D G Y C A+N
Sbjct: 285 GNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKN 344

Query: 493 FMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPID 552
            +G  + T  + V+ A     AP +  ++ G++ TL C A+ +P   +  +W  +  PI+
Sbjct: 345 ALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRI--SWLTNGVPIE 402

Query: 553 F--DKPGGHYRRTNVKETIGDLTIL-NAQLRHGGKYTCMAQTVVDSASKEATVLVRGPP 608
              D P         ++  GD  I  N Q R    Y C A          A V V   P
Sbjct: 403 IAPDDPS--------RKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEP 453



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 84/373 (22%), Positives = 137/373 (36%), Gaps = 78/373 (20%)

Query: 315 DTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPL 367
           D VQ   I Q  P+      D   D   N+   C A GKP P+  W RNG       +PL
Sbjct: 41  DLVQPPTITQQSPK------DYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPL 94

Query: 368 ASQN-RVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDF---RLNP 423
            +       L  ++     +    G+YQC A N+ G   ++  +   + +P +   +L P
Sbjct: 95  VTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEP 154

Query: 424 VRRLIPAARGGEILIPCQPR-AAPKAVVLWSKGT-EILVNSSRVTVTPDGTLIIRNISRS 481
               I    G  +++PC+P    P  ++ W   + + L  S RV+   +G L   N+   
Sbjct: 155 ----ITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPE 210

Query: 482 DEGK-YTCFAE-NFMGKANSTGILSVR----DATKITLAPSSADINL------------- 522
           D  + Y C+A  N          +SV+    D    T+A + +D                
Sbjct: 211 DTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTF 270

Query: 523 --------------GDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKET 568
                         G+ L+L+C A   PT      W  +D  +          RT  K  
Sbjct: 271 LTPEGNASNKEELRGNVLSLECIAEGLPTP--IIYWAKEDGMLP-------KNRTVYKNF 321

Query: 569 IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRG-------------PPGPPGGVV 615
              L I++      G Y C+A+  + +     +V V+               PG  G ++
Sbjct: 322 EKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI 381

Query: 616 VRDIGDTTIQLSW 628
            R  G+   ++SW
Sbjct: 382 CRANGNPKPRISW 394



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 61/271 (22%), Positives = 105/271 (38%), Gaps = 33/271 (12%)

Query: 52  STEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQC 111
           S  E   L CRA  +P     W  NG  +++ P    + + G+ +I +  + + + VYQC
Sbjct: 373 SPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQC 432

Query: 112 LASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPA-------HYPGL 164
            ASN  G +++        F+   ++  R    A+  + V+   N PA         P  
Sbjct: 433 NASNEYGYLLAN------AFVNVLAEPPRILTPANTLYQVI--ANRPALLDCAFFGSPLP 484

Query: 165 SYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKF 224
           +  W      + +  D   +V    G L I        G Y+C+A + +  +   V    
Sbjct: 485 TIEWFKGAKGSALHED--IYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEV---- 538

Query: 225 AQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPV--PRIKWRKVDGSL-- 280
              +L  +D     P+   + P       G  V+ EC    +      + W K +  L  
Sbjct: 539 ---HLEIKD-----PTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPS 590

Query: 281 SPQWTTAEPTLQIPSVSFEDEGTYECEAENS 311
             ++T  +  L +  VS +D GTY C A  +
Sbjct: 591 DERFTVDKDHLVVADVSDDDSGTYTCVANTT 621


>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
          Length = 1174

 Score =  365 bits (937), Expect = e-100
 Identities = 277/945 (29%), Positives = 423/945 (44%), Gaps = 78/945 (8%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 51  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170

Query: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFST--KSVFSKFAQ 226
            +       T  +       G+LY +     D+  +YSC A  H   +   K+ F+    
Sbjct: 171 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVL 228

Query: 227 LNLAAEDTRL-------FAPSIKARFPAETY---------ALVGQQVTLECFAFGNPVPR 270
            N    D+ L        A  +  R P+  Y          L G  + LEC A G P P 
Sbjct: 229 TNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD 288

Query: 271 IKWRKVDGSL---SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQA 325
           I W K  G L     ++      L+I +VS ED G Y C A N  G  R T+  R  V+A
Sbjct: 289 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKA 346

Query: 326 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRF 382
            P WL    +     G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F
Sbjct: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 406

Query: 383 SKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP 442
               +    +YQC   N+HG + A+A ++V  + P   L+P  +LI         + C  
Sbjct: 407 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPF 465

Query: 443 RAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501
             +P   + W K G    ++     V  +G+L I+ I + D+G YTC A N +GKA +  
Sbjct: 466 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 525

Query: 502 ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR 561
            L V+D T+I   P       G  + L+C   HDP++ LT +W  DD P+        Y 
Sbjct: 526 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YI 577

Query: 562 RTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGD 621
              +K+    LTI     R  G YTC+A T +D    +A + V G P  P  + + D+ +
Sbjct: 578 GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAE 637

Query: 622 TTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIEGNAETAQVLGLTPWM 679
            +++L+W  G  N+SPI  Y +Q        G W      P ++      + VL L+P++
Sbjct: 638 RSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV-----NSAVLRLSPYV 692

Query: 680 DYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQ 739
           +Y+FRVIA N +G+  PS PS + RT  A P   P  + G G     + + WTPM+    
Sbjct: 693 NYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSA 752

Query: 740 NGDGFGYLLSFRRQGSTH-WQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP 798
            G    Y++ +RR+ +   W    V G+    +V     V  Y P+E+++++ N  G GP
Sbjct: 753 FGPNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPV--YVPYEIRVQAENDFGKGP 807

Query: 799 ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQD-MNGILLGYEIRYWKAGD- 856
           E  + + YS E+ PR APT+V  + ++S+ +++ W  V  D + G L  Y   YW+    
Sbjct: 808 EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSL 867

Query: 857 ----------KEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANAT 906
                     ++A+    R  G+     VS L P + Y + +   N  G GP S +   T
Sbjct: 868 LKNLWVSQKRQQASFPGDRLRGV-----VSRLFPYSNYKLEMVVVNGRGDGPRSETKEFT 922

Query: 907 TMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           T +  P  P        +  +++++WD   P      + GY + Y
Sbjct: 923 TPEGVPSAPRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 965



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 88/354 (24%), Positives = 124/354 (35%), Gaps = 76/354 (21%)

Query: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 44  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103

Query: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 159

Query: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTCFAE--------- 491
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C A          
Sbjct: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219

Query: 492 --------------NFMGKANSTGILSVRDATKITLA-------PSSADINLGDNLTLQC 530
                         N     N   + S R   + T +        SS  +  G +L L+C
Sbjct: 220 KNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 279

Query: 531 HASHDPTMDLTFTWTLDDFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
            AS  PT D+ +     D P D   F+      R TNV E               G+Y C
Sbjct: 280 IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSE------------EDSGEYFC 327

Query: 588 MAQTVVDSASKEATVLVRG-------------PPGPPGGVVVRDIGDTTIQLSW 628
           +A   + S     +V V+               PG  G +V R  G+    + W
Sbjct: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 381


>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
          Length = 1169

 Score =  365 bits (937), Expect = e-100
 Identities = 277/945 (29%), Positives = 423/945 (44%), Gaps = 78/945 (8%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 51  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170

Query: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFST--KSVFSKFAQ 226
            +       T  +       G+LY +     D+  +YSC A  H   +   K+ F+    
Sbjct: 171 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVL 228

Query: 227 LNLAAEDTRL-------FAPSIKARFPAETY---------ALVGQQVTLECFAFGNPVPR 270
            N    D+ L        A  +  R P+  Y          L G  + LEC A G P P 
Sbjct: 229 TNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD 288

Query: 271 IKWRKVDGSL---SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQA 325
           I W K  G L     ++      L+I +VS ED G Y C A N  G  R T+  R  V+A
Sbjct: 289 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKA 346

Query: 326 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRF 382
            P WL    +     G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F
Sbjct: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 406

Query: 383 SKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP 442
               +    +YQC   N+HG + A+A ++V  + P   L+P  +LI         + C  
Sbjct: 407 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPF 465

Query: 443 RAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501
             +P   + W K G    ++     V  +G+L I+ I + D+G YTC A N +GKA +  
Sbjct: 466 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 525

Query: 502 ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR 561
            L V+D T+I   P       G  + L+C   HDP++ LT +W  DD P+        Y 
Sbjct: 526 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YI 577

Query: 562 RTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGD 621
              +K+    LTI     R  G YTC+A T +D    +A + V G P  P  + + D+ +
Sbjct: 578 GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGRPDRPRDLELTDLAE 637

Query: 622 TTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIEGNAETAQVLGLTPWM 679
            +++L+W  G  N+SPI  Y +Q        G W      P ++      + VL L+P++
Sbjct: 638 RSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV-----NSAVLRLSPYV 692

Query: 680 DYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQ 739
           +Y+FRVIA N +G+  PS PS + RT  A P   P  + G G     + + WTPM+    
Sbjct: 693 NYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSA 752

Query: 740 NGDGFGYLLSFRRQGSTH-WQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP 798
            G    Y++ +RR+ +   W    V G+    +V     V  Y P+E+++++ N  G GP
Sbjct: 753 FGPNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPV--YVPYEIRVQAENDFGKGP 807

Query: 799 ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQD-MNGILLGYEIRYWKAGD- 856
           E  + + YS E+ PR APT+V  + ++S+ +++ W  V  D + G L  Y   YW+    
Sbjct: 808 EPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSL 867

Query: 857 ----------KEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANAT 906
                     ++A+    R  G+     VS L P + Y + +   N  G GP S +   T
Sbjct: 868 LKNLWVSQKRQQASFPGDRLRGV-----VSRLFPYSNYKLEMVVVNGRGDGPRSETKEFT 922

Query: 907 TMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           T +  P  P        +  +++++WD   P      + GY + Y
Sbjct: 923 TPEGVPSAPRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 965



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 88/354 (24%), Positives = 124/354 (35%), Gaps = 76/354 (21%)

Query: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 44  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103

Query: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 159

Query: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTCFAE--------- 491
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C A          
Sbjct: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219

Query: 492 --------------NFMGKANSTGILSVRDATKITLA-------PSSADINLGDNLTLQC 530
                         N     N   + S R   + T +        SS  +  G +L L+C
Sbjct: 220 KNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 279

Query: 531 HASHDPTMDLTFTWTLDDFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
            AS  PT D+ +     D P D   F+      R TNV E               G+Y C
Sbjct: 280 IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSE------------EDSGEYFC 327

Query: 588 MAQTVVDSASKEATVLVRG-------------PPGPPGGVVVRDIGDTTIQLSW 628
           +A   + S     +V V+               PG  G +V R  G+    + W
Sbjct: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 381


>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
          Length = 1189

 Score =  357 bits (915), Expect = 4e-98
 Identities = 276/960 (28%), Positives = 423/960 (44%), Gaps = 93/960 (9%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 51  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170

Query: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFST--KSVFSKFAQ 226
            +       T  +       G+LY +     D+  +YSC A  H   +   K+ F+    
Sbjct: 171 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVL 228

Query: 227 LNLAAEDTRL-------FAPSIKARFPAETY---------ALVGQQVTLECFAFGNPVPR 270
            N    D+ L        A  +  R P+  Y          L G  + LEC A G P P 
Sbjct: 229 TNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPD 288

Query: 271 IKWRKVDGSL---SPQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQA 325
           I W K  G L     ++      L+I +VS ED G Y C A N  G  R T+  R  V+A
Sbjct: 289 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKA 346

Query: 326 QPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRF 382
            P WL    +     G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F
Sbjct: 347 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 406

Query: 383 SKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQP 442
               +    +YQC   N+HG + A+A ++V  + P   L+P  +LI         + C  
Sbjct: 407 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPF 465

Query: 443 RAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTG 501
             +P   + W K G    ++     V  +G+L I+ I + D+G YTC A N +GKA +  
Sbjct: 466 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 525

Query: 502 ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYR 561
            L V+D T+I   P       G  + L+C   HDP++ LT +W  DD P+        Y 
Sbjct: 526 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YI 577

Query: 562 RTNVKETIGDLTILNAQLRHGGKYTCMAQTVVD---------------SASKEATVLVRG 606
              +K+    LTI     R  G YTC+A T +D               + +     L +G
Sbjct: 578 GNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKG 637

Query: 607 PPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIE 664
            P  P  + + D+ + +++L+W  G  N+SPI  Y +Q        G W      P ++ 
Sbjct: 638 RPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV- 696

Query: 665 GNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAP 724
                + VL L+P+++Y+FRVIA N +G+  PS PS + RT  A P   P  + G G   
Sbjct: 697 ----NSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRK 752

Query: 725 GELIVNWTPMSREYQNGDGFGYLLSFRRQGSTH-WQTARVPGADAQYFVYSNESVRPYTP 783
             + + WTPM+     G    Y++ +RR+ +   W    V G+    +V     V  Y P
Sbjct: 753 NNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPV--YVP 807

Query: 784 FEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQD-MNG 842
           +E+++++ N  G GPE  + + YS E+ PR APT+V  + ++S+ +++ W  V  D + G
Sbjct: 808 YEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQG 867

Query: 843 ILLGYEIRYWKAGD-----------KEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAY 891
            L  Y   YW+              ++A+    R  G+     VS L P + Y + +   
Sbjct: 868 QLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGV-----VSRLFPYSNYKLEMVVV 922

Query: 892 NRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           N  G GP S +   TT +  P  P        +  +++++WD   P      + GY + Y
Sbjct: 923 NGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDH--PEHPNGIMIGYTLKY 980



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 88/354 (24%), Positives = 124/354 (35%), Gaps = 76/354 (21%)

Query: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 44  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103

Query: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 159

Query: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTCFAE--------- 491
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C A          
Sbjct: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219

Query: 492 --------------NFMGKANSTGILSVRDATKITLA-------PSSADINLGDNLTLQC 530
                         N     N   + S R   + T +        SS  +  G +L L+C
Sbjct: 220 KNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 279

Query: 531 HASHDPTMDLTFTWTLDDFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
            AS  PT D+ +     D P D   F+      R TNV E               G+Y C
Sbjct: 280 IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSE------------EDSGEYFC 327

Query: 588 MAQTVVDSASKEATVLVRG-------------PPGPPGGVVVRDIGDTTIQLSW 628
           +A   + S     +V V+               PG  G +V R  G+    + W
Sbjct: 328 LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 381


>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
          Length = 1240

 Score =  348 bits (893), Expect = 2e-95
 Identities = 266/917 (29%), Positives = 406/917 (44%), Gaps = 72/917 (7%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 57  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176

Query: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFSTKSVFSKFAQLN 228
            +       T  +       G+LY +     D+  +YSC A  H   + +   + F    
Sbjct: 177 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK-NPFTLKV 233

Query: 229 LAAEDTRLFAPSIKARFPAETYA----LVGQQVTLECFAFGNPVPRIKWRKVDGSL---S 281
           L         PS    +P  T +    L G  + LEC A G P P I W K  G L    
Sbjct: 234 LTTRGVAERTPSFM--YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 291

Query: 282 PQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQAQPEWLKVISDTEAD 339
            ++      L+I +VS ED G Y C A N  G  R T+  R  V+A P WL    +    
Sbjct: 292 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKAAPYWLDEPKNLILA 349

Query: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRFSKLSLEDSGMYQCV 396
            G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F    +    +YQC 
Sbjct: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409

Query: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-G 455
             N+HG + A+A ++V  + P   L+P  +LI         + C    +P   + W K G
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468

Query: 456 TEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAP 515
               ++     V  +G+L I+ I + D+G YTC A N +GKA +   L V+D T+I   P
Sbjct: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528

Query: 516 SSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL 575
                  G  + L+C   HDP++ LT +W  DD P+        Y    +K+    LTI 
Sbjct: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIF 580

Query: 576 NAQLRHGGKYTCMAQTVVD---------------SASKEATVLVRGPPGPPGGVVVRDIG 620
               R  G YTC+A T +D               + +     L +G P  P  + + D+ 
Sbjct: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLA 640

Query: 621 DTTIQLSWSRGFDNHSPIAKYTLQARTP--PAGKWKQVRTNPANIEGNAETAQVLGLTPW 678
           + +++L+W  G  N+SPI  Y +Q        G W      P ++      + VL L+P+
Sbjct: 641 ERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV-----NSAVLRLSPY 695

Query: 679 MDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREY 738
           ++Y+FRVIA N +G+  PS PS + RT  A P   P  + G G     + + WTPM+   
Sbjct: 696 VNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATS 755

Query: 739 QNGDGFGYLLSFRRQGSTH-WQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDG 797
             G    Y++ +RR+ +   W    V G+    +V     V  Y P+E+++++ N  G G
Sbjct: 756 AFGPNLRYIVKWRRRETREAWNNVTVWGS---RYVVGQTPV--YVPYEIRVQAENDFGKG 810

Query: 798 PESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDK 857
           PE  + + YS E+ P  AP +   +  +   +N+ W+  +   NGI++GY ++Y      
Sbjct: 811 PEPESVIGYSGEDLPS-APRRFRVRQPNLETINLEWDHPEHP-NGIMIGYTLKYVAFNGT 868

Query: 858 EAAADRVRT-AGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPA------SPSANATTMKP 910
           +     V   +   T   V    P ++Y  T+ A  + G+G A      +P   AT    
Sbjct: 869 KVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAA 928

Query: 911 PPRRPPGNISWTFSSSS 927
           PP  PP  +  T + SS
Sbjct: 929 PPTLPPTTVGATGAVSS 945



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 88/337 (26%), Positives = 125/337 (37%), Gaps = 59/337 (17%)

Query: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 50  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109

Query: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 165

Query: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTC-----FAENFMG 495
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C     F      
Sbjct: 166 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 225

Query: 496 KANST-GILSVRDATKITLA-------PSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547
           K   T  +L+ R   + T +        SS  +  G +L L+C AS  PT D+ +     
Sbjct: 226 KNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGG 285

Query: 548 DFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
           D P D   F+      R TNV E               G+Y C+A   + S     +V V
Sbjct: 286 DLPSDKAKFENFNKALRITNVSE------------EDSGEYFCLASNKMGSIRHTISVRV 333

Query: 605 RG-------------PPGPPGGVVVRDIGDTTIQLSW 628
           +               PG  G +V R  G+    + W
Sbjct: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  294 bits (752), Expect = 3e-79
 Identities = 280/1058 (26%), Positives = 447/1058 (42%), Gaps = 96/1058 (9%)

Query: 31   SQTTFGPVFEDQPLSVLFPEESTE-EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQ 89
            +Q    P F+ +P     P+   E  +++L C A  S P  ++W  + +E+         
Sbjct: 98   AQDDVAPYFKTEPG---LPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYKY 154

Query: 90   LVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEF-SKEERDPVKAHEG 148
            ++          +  DAG Y+C+  N +G ++ R++ ++  ++  F   ++R  V   +G
Sbjct: 155  IIPS-------LQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVS--QG 205

Query: 149  WGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208
               +L   P   YP     W   E    IP++           L I  T  SD G Y   
Sbjct: 206  RAAILNLLPITSYPRPQVTWF-REGHKIIPSN--RIAITLENQLVILATTTSDAGAYYVQ 262

Query: 209  ATSHMDFSTKSVFSKFAQLNLAAE--DTRLFAPSIKARFPAETYALVGQQVTLECFAFGN 266
            A +  +   K+  S F  L++A +       AP+I       +      + TLEC A   
Sbjct: 263  AVNEKNGENKT--SPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASAR 320

Query: 267  PVP--RIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAEN-----SKGRDTVQG 319
            PV    + W++    ++    +    L I + +  D G Y CEA          R T   
Sbjct: 321  PVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFL 380

Query: 320  RII----VQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLAS-QN-RV 373
             II      A+PE     S   A++   +  GC A G P PT++W ++   ++  QN R 
Sbjct: 381  FIIEPPYFTAEPE-----SRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY 435

Query: 374  EVLA-GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAAR 432
            +VLA G LR  KL  EDSG++QC A N+ G I     L V  +AP F   PV   +    
Sbjct: 436  KVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTV--TD 493

Query: 433  GGEILIPCQPRAAPKAVVLWSKGTEILVNSS----RVTVTPDGTLIIRNISRSDEGKYTC 488
            G   ++ C+   APK  + W +   IL + S    R  +   G L I  +   D G YTC
Sbjct: 494  GMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTC 553

Query: 489  FAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDD 548
            +A N  G  N++  L+V + T I   P    +  G   TL C A+HDP + L + W  D+
Sbjct: 554  YAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDN 613

Query: 549  FPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPP 608
              +    P    R   V E  G L I        G Y+C   +   + S+ A + V   P
Sbjct: 614  VAL---TPSSTSR--IVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELP 668

Query: 609  GPPGGVVV--RDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGN 666
              P  ++V         + LSW R FD +SPI  Y ++  +     WK    + +N+   
Sbjct: 669  HSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVEL-SENNSPWK---VHLSNVGPE 724

Query: 667  AETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGE 726
                 V GLTP   Y+FRV A N +G G+ S  +S++   E  PS  P  +   G     
Sbjct: 725  MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQS 784

Query: 727  LIVNWTPMSREYQNGDGFGYLLSFRRQG-STHWQTARVPGADAQYFVYSNESVRPYTPFE 785
            ++V W P      NG   GY+L +R  G    +Q   +   +  Y + ++  +  +T +E
Sbjct: 785  IMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLII--WTQYE 842

Query: 786  VKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNGIL 844
            +++ +YN  G G  S     Y+ +  P   P  V  + V+S+ +   W  P QQ +NGI 
Sbjct: 843  IQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGIN 902

Query: 845  LGYEIRYWKAGDKEAAADRVRTAGLD----TSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900
             GY++  W A   EA    V T   D        ++ L   T Y  +V  +   G GP S
Sbjct: 903  QGYKLLAWPADAPEAVT--VVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS 960

Query: 901  PSANATTMKPPPRRPPGNISWT-FSSSSLSIKWDPVVPFRNESAVTGYKMLYQ----NDL 955
                  T +  P    G++S+T    +SL + W    P      +TGY++ ++    ND 
Sbjct: 961  TPQLVWTQEDKP-GAVGHLSFTEILDTSLKVSWQE--PLEKNGIITGYQISWEVYGRNDS 1017

Query: 956  HLTPTLHLTGKNW------------IEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRN 1003
             LT TL+ T   +            I++     +G  LV   T+     G+P +   +  
Sbjct: 1018 RLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLV---TSSTISSGVPPD---LPG 1071

Query: 1004 GGTSMMVENMAVRPAP---HPGTVISHSVAMLILIGSL 1038
              +++++ N++ R A     PG     S++  I+ G +
Sbjct: 1072 APSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQV 1109



 Score =  142 bits (359), Expect = 1e-33
 Identities = 103/382 (26%), Positives = 178/382 (46%), Gaps = 34/382 (8%)

Query: 599  EATVLV---RGPPGPPGGVVV--RDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKW 653
            EATV+    R  P PP  ++V   ++   +++L W  G D  SPI  +T+Q R  P G+W
Sbjct: 1465 EATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEW 1524

Query: 654  KQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVA 713
            +   T  ++I   A    V  L P+  Y+ R+ A+N +G  + S  +  + T +  P   
Sbjct: 1525 Q---TYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581

Query: 714  PSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQ-----GSTHWQTARVP---- 764
            P  +S        +++ W P   E  NG   GY + +R         T  +T + P    
Sbjct: 1582 PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALH 1641

Query: 765  ---GADAQYFVYSNES---------VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEP 812
                A + +   ++ S         ++ Y  +EV + +YN  G+ P S    V+  E  P
Sbjct: 1642 AELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAP 1701

Query: 813  RVAPTKVWAKGVSSSEMNVTWE-PVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGL-D 870
             +AP  V    +++S++ VTW+ P  +  NG + GY+I YW+A D +   ++++   L +
Sbjct: 1702 AMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEA-DSQNETEKMKVLFLPE 1760

Query: 871  TSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSI 930
               R+  L  +TKY V++ A+N AG GP S      T +  P  P        +S++L++
Sbjct: 1761 PVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNV 1820

Query: 931  KWDPVVPFRNESAVTGYKMLYQ 952
             W    P      + GY+++Y+
Sbjct: 1821 SWGE--PAAANGILQGYRVVYE 1840



 Score =  129 bits (323), Expect = 2e-29
 Identities = 97/351 (27%), Positives = 168/351 (47%), Gaps = 10/351 (2%)

Query: 608  PGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQ-VRTNPANIEGN 666
            PG P  +V+ +I   +  L +  G+D  + I+++ ++ +    G  ++ V       E +
Sbjct: 1070 PGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129

Query: 667  AETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGE 726
            A+  ++  LTP+  Y FR+   NI+G    S  S  I+T +A P VAP+ ++    +   
Sbjct: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189

Query: 727  LIVNWTPMSREYQNG--DGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPF 784
            L + W P+     NG  +  GY + + R        A+V  +D     ++ E +  +  +
Sbjct: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVV-SDRLEREFTIEELEEWMEY 1248

Query: 785  EVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPV-QQDMNGI 843
            E++++++N  G GP S      + E  P  AP  V A+ VSS+++ +TW  V +QD NG+
Sbjct: 1249 ELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGL 1308

Query: 844  LLGYEIRY-WKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTG-PASP 901
            +LGY+I +  K  D E  +  VR      SA ++GL     Y + V A+ R G G P++P
Sbjct: 1309 ILGYKILFRAKDLDPEPRSHIVR-GNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTP 1367

Query: 902  SANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952
                 T    P  P   +      +S+ I W P  P      + GY++ Y+
Sbjct: 1368 LILERTKDDAPGPPVRLVFPEVRLTSVRIVWQP--PEEPNGIILGYQIAYR 1416



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 86/366 (23%), Positives = 153/366 (41%), Gaps = 50/366 (13%)

Query: 595  SASKEATVLVRGPPG-PPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKW 653
            S S      ++ PP   P  V VR   +T+++L W    D+         Q    P    
Sbjct: 1160 SPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS---------QYNGNPESVG 1210

Query: 654  KQVRTNPANIEGNAETAQVLG-----------LTPWMDYEFRVIASNILGTGEPSGPSSK 702
             +++   ++++ +A  AQV+            L  WM+YE ++ A N +G G P     +
Sbjct: 1211 YRIKYWRSDLQSSA-VAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAG-PWSEVVR 1268

Query: 703  IRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQG-------- 754
             RTRE+ PS AP  +S    +  ++++ WT +  + QNG   GY + FR +         
Sbjct: 1269 GRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSH 1328

Query: 755  ---STHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE 811
                 H Q+A + G            +R +  +E+++ ++ R G+G  S   ++   +++
Sbjct: 1329 IVRGNHTQSALLAG------------LRKFVLYELQVLAFTRIGNGVPSTPLILERTKDD 1376

Query: 812  PRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDT 871
                P ++    V  + + + W+P ++  NGI+LGY+I Y  A         V       
Sbjct: 1377 APGPPVRLVFPEVRLTSVRIVWQPPEEP-NGIILGYQIAYRLASSSPHTFTTVEVGATVR 1435

Query: 872  SARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNI---SWTFSSSSL 928
                + L P + Y   + A  R G G    +   TT K     PP  +       ++ SL
Sbjct: 1436 QFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495

Query: 929  SIKWDP 934
             ++W P
Sbjct: 1496 RLQWVP 1501



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 38/130 (29%), Positives = 59/130 (45%), Gaps = 7/130 (5%)

Query: 585  YTCMAQTVVDSASKEATVLV---RGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKY 641
            +   A+T+      +A +      G PG P  V+V     + + L W+ G    +P   Y
Sbjct: 1877 FRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSA-SELTLQWTEGHSGDTPTTGY 1935

Query: 642  TLQARTPPAGKWKQ-VRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPS 700
             ++AR    G W   V+  P +    + T  +  L   + YEFRV+A N  G GEPS PS
Sbjct: 1936 VIEARPSDEGLWDMFVKDIPRS--ATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPS 1993

Query: 701  SKIRTREAAP 710
            + +  +  AP
Sbjct: 1994 TAVSAQVEAP 2003


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  282 bits (722), Expect = 1e-75
 Identities = 245/954 (25%), Positives = 408/954 (42%), Gaps = 66/954 (6%)

Query: 28  ALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEM-KLEPGS 86
           A  +Q    P F+ +P+      E    +++L C A  S P  ++W  N  E+ K     
Sbjct: 17  AARAQDDVSPYFKTEPVRTQVHLEGN--RLVLTCMAEGSWPLEFKWLHNNRELTKFSLEY 74

Query: 87  RHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAH 146
           R+ +               AG Y+C+  N +G ++ R+  ++  ++  F + E+    +H
Sbjct: 75  RYMITS--------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSH 126

Query: 147 EGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYS 206
            G   ++     A +P     W  +     IP   R  ++     L I  T A D G Y 
Sbjct: 127 -GEAAVIRAPRIASFPQPQVTWFRDG--RKIPPSSRIAIT-LENTLVILSTVAPDAGRYY 182

Query: 207 CLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVG-QQVTLECFAFG 265
             A +  +   K+       +          AP+I    P  T  + G  +VTLEC A  
Sbjct: 183 VQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIP-PKNTSVVAGTSEVTLECVANA 241

Query: 266 NPVPRIK--WRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEA--ENSKGRDTVQGRI 321
            P+ ++   W+K    LS   +     L IP+ +  D G YECEA   +S     V+G  
Sbjct: 242 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301

Query: 322 IVQAQPEWLKVISDTEADIGSNLRW----GCAAAGKPRPTVRWLRNGEPLASQNRVEVLA 377
           +   +P   + + + E  I + +       C A G P P++ W ++    A+   VE L 
Sbjct: 302 LSVLEPP--QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKD----AAVVEVEKLT 355

Query: 378 -------GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPA 430
                  G L+ S L  +D+GM+QC A N  G +  S  LAV ++AP+    P+   +  
Sbjct: 356 RFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTV-- 413

Query: 431 ARGGEILIPCQPRAAPKAVVLWSKGTEILVNSS----RVTVTPDGTLIIRNISRSDEGKY 486
             G  +++ C+   AP+  + W KG  IL + S    R T    G+L+I     SD G Y
Sbjct: 414 IDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTY 473

Query: 487 TCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTL 546
           TC A N  G   ++  L V   T+IT  P    +  G   ++ C  +HDP + + + W  
Sbjct: 474 TCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK 533

Query: 547 DDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606
           D   +  +     + R  +    G L I        G YTC   +   + S+ A + VR 
Sbjct: 534 DGATLGTES----HPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ 588

Query: 607 PPGPPGGVV--VRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIE 664
            P  P   V  +  +    I L+W++ FD +SP+ +Y L+     A  W  +    A+++
Sbjct: 589 LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNA-PWTVLL---ASVD 644

Query: 665 GNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAP 724
             A +  V GL P   Y+FR+ A N +G G+ S  + ++   E  P+  P  +   G   
Sbjct: 645 PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN 704

Query: 725 GELIVNWTPMSREYQNGDGFGYLLSFRRQG-STHWQTARVPGADAQYFVYSNESVRPYTP 783
             +++ W P    +QNG   GY++ +   G    +Q   +  AD    +   E +  +T 
Sbjct: 705 QSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL--EDLIIWTN 762

Query: 784 FEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNG 842
           +E+++ +YN  G G  S     ++ +  P V P  V A+  +S+ +  TW  P  Q +NG
Sbjct: 763 YEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFING 822

Query: 843 ILLGYEIRYWKAGDKEAAADRVRTAGLDTSAR---VSGLHPNTKYHVTVRAYNRAGTGPA 899
           I  GY++  W+   +E             S     VSGL   T+Y  +V  +   G GP 
Sbjct: 823 INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPR 882

Query: 900 SPSANATTMKPPPRRPPGNISWT-FSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952
           S      T +  P  P G++S++    +SL + W    P      +TGY++ ++
Sbjct: 883 STPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWE 933



 Score =  160 bits (405), Expect = 6e-39
 Identities = 120/417 (28%), Positives = 196/417 (47%), Gaps = 38/417 (9%)

Query: 560  YRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVR-- 617
            Y  T +K     L  + AQ R G      A  V        T   R  P PP   +V+  
Sbjct: 1360 YTATGLKPESVYLFRITAQTRKGWGEAAEALVV--------TTEKRDRPQPPSRPMVQQE 1411

Query: 618  DIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTP 677
            D+   ++ LSW  G D  SP+  YT+Q R  P+G+W     + A++  NA +  V  L P
Sbjct: 1412 DVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWA---LHSASVSHNASSFIVDRLKP 1468

Query: 678  WMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSRE 737
            +  Y+FRV A+N +G  E S  S  + T +AAP  AP+ LS        +++ W P + +
Sbjct: 1469 FTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAED 1528

Query: 738  YQNGDGFGYLLSFRR---QGSTHWQTARV--PGA-----DAQYFV----------YSNES 777
              NG   G+ + +R    +G   +    +  PGA      + Y +          Y  ++
Sbjct: 1529 KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDN 1588

Query: 778  VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ 837
            +  +  +E+++  YN  G+GP S    V+  E  P  AP  V   G ++++++VTWEP  
Sbjct: 1589 LNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPP 1648

Query: 838  QD-MNGILLGYEIRYWKAGDKEAAADRVRTAGL-DTSARVSGLHPNTKYHVTVRAYNRAG 895
             D  NG + GY+I +W+A  +    +RV+T  L + S ++  L   T Y V+V A+N AG
Sbjct: 1649 LDSQNGDIQGYKIYFWEA-QRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAG 1707

Query: 896  TGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952
             GP S      T +  P  P        +++S+++ W+   P      + GY+++Y+
Sbjct: 1708 DGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE--APQFPNGILEGYRLVYE 1762



 Score =  149 bits (376), Expect = 1e-35
 Identities = 130/485 (26%), Positives = 215/485 (44%), Gaps = 46/485 (9%)

Query: 523  GDNLTLQCHASHD----PTMDLTFTWTLD-DFPIDFDKPGG-------------HYRRTN 564
            G   T Q   +H+    P   L+F+  LD    + + +PG               Y RTN
Sbjct: 880  GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTN 939

Query: 565  VKET-----------IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGG 613
             + T           +  LT L          T   Q  V SAS  ++ +    PGPP  
Sbjct: 940  TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQV-SASTISSGVPPELPGPPTN 998

Query: 614  VVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQ-VRTNPANIEGNAETAQV 672
            + + +IG  ++ L +  G+D  + I+++ ++A+    G+ ++ +  +  + E +A + +V
Sbjct: 999  LGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEV 1058

Query: 673  LGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWT 732
              L P+  Y FR+   NI+GT  PS PS KI+T +A P +AP+ +S    +   L + W 
Sbjct: 1059 PDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWM 1118

Query: 733  PMSREYQNG--DGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRS 790
            P+     NG  +  GY + + R    H +T      D     Y+ E +  +T + V++++
Sbjct: 1119 PLPEMEYNGNPESVGYKIKYSRSDG-HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQA 1177

Query: 791  YNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPV-QQDMNGILLGYEI 849
            +N  G GP S T +  + E  P   PT V A   +SS M V W  V + D NG++LGY++
Sbjct: 1178 FNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237

Query: 850  RYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTG-PASPSANATTM 908
             Y +          +       SA+++GL     Y V V A+ R G G P+ P     T+
Sbjct: 1238 MYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTL 1297

Query: 909  KPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNW 968
               P  P G +     ++S+ + W P       +A  G  + YQ    +T  L+ T  N 
Sbjct: 1298 DDVPGPPMGILFPEVRTTSVRLIWQP------PAAPNGIILAYQ----ITHRLNTTTANT 1347

Query: 969  IEIPV 973
              + V
Sbjct: 1348 ATVEV 1352



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 79/305 (25%), Positives = 139/305 (45%), Gaps = 22/305 (7%)

Query: 663  IEGNAE-TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGG 721
            +EGN+  +AQ+ GL  ++ YE +V+A   +G G PS P    RT +  P   P G+    
Sbjct: 1253 VEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPG-PPMGILFPE 1311

Query: 722  GAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPY 781
                 + + W P +    NG    Y ++ R   +T   TA V         Y+   ++P 
Sbjct: 1312 VRTTSVRLIWQPPAAP--NGIILAYQITHRLNTTTA-NTATVEVLAPSARQYTATGLKPE 1368

Query: 782  TPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTK---VWAKGVSSSEMNVTWEPVQQ 838
            + +  +I +  R+G G E+  ALV + E+  R  P     V  + V +  + ++WEP   
Sbjct: 1369 SVYLFRITAQTRKGWG-EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSD 1427

Query: 839  DMNGILLGYEIRYWKAGDKEAAADR--VRTAGLDTSAR---VSGLHPNTKYHVTVRAYNR 893
             ++       +RY+    +E  + R  + +A +  +A    V  L P T Y   V+A N 
Sbjct: 1428 GLS------PVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND 1481

Query: 894  AGTGPASP-SANATTMKPPPRRPPGNISWT-FSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
             G    S  S + TT++  P   P  +S T  +++S+ I+W P    +    + G+++ Y
Sbjct: 1482 IGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541

Query: 952  QNDLH 956
            +  L+
Sbjct: 1542 RELLY 1546



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 9/132 (6%)

Query: 584  KYTCMAQTVVDSASKEATVLV---RGPPGPPG-GVVVRDIGDTTIQLSWSRGFDNHSPIA 639
            ++   A+T       EA V      G PGPPG  ++VR    + I + WS G     PI 
Sbjct: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRY--SSAIAIHWSSGDPGKGPIT 1855

Query: 640  KYTLQARTPPAGKWK-QVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSG 698
            +Y ++AR    G W   ++  P  +     +  +L   P + Y+FRVIA N  G G PS 
Sbjct: 1856 RYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDIL--KPGVSYDFRVIAVNDYGFGTPSS 1913

Query: 699  PSSKIRTREAAP 710
            PS  +  ++A P
Sbjct: 1914 PSQSVPAQKANP 1925


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  231 bits (590), Expect = 2e-60
 Identities = 235/956 (24%), Positives = 380/956 (39%), Gaps = 87/956 (9%)

Query: 26   SSALGSQTTFGPVFEDQPLSVLFP----EESTEEQVLLACRARASPPATYRWKMNGTEMK 81
            S+  G+    G ++  QPL         + S   QV L+C    +      W  NG    
Sbjct: 296  SNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEI-- 353

Query: 82   LEPGSRHQLVGGNL--VIMNPTKAQDAGVYQCLA-SNPVGTVVSREAILRFG---FLQEF 135
            L PG   ++ G N   +IM+     D G YQC    + +      + +L  G    +  F
Sbjct: 354  LNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF 413

Query: 136  SKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQ---TTGN- 191
            S++   P +      V L CN     P  +  W L++ P  I   G H +SQ   + GN 
Sbjct: 414  SEKVVSPAEP-----VSLMCNVKGT-PLPTITWTLDDDP--ILKGGSHRISQMITSEGNV 465

Query: 192  ---LYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAE 248
               L I+ +   D G Y C A +                   +    L+   I  R PA 
Sbjct: 466  VSYLNISSSQVRDGGVYRCTANN-------------------SAGVVLYQARINVRGPAS 506

Query: 249  TY------ALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTA----EPTLQIPSVSF 298
                    A+ G+   + C   G P   IKW K    L             TL++  V  
Sbjct: 507  IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566

Query: 299  E-DEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRP- 356
            E DEG Y C         T Q   +    P +++        IG  +   C       P 
Sbjct: 567  EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPI 626

Query: 357  TVRWLRNGEPLASQNRVEV----LAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAV 412
            T+ W ++G P+     V +        LR S LSL  +G Y C+A N+   +   ++L V
Sbjct: 627  TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686

Query: 413  QALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLW--SKGTEI-----LVNSSRV 465
            + + P F + P  R      G  +++ C     P   ++W  SKG  +     +  + R+
Sbjct: 687  R-VPPKFVVQP--RDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRI 743

Query: 466  TVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGI-LSVRDATKITLAPSSADINLGD 524
             V  +G+L+I+++   D G Y C   N +G   S  + L+V+    IT  P++     G 
Sbjct: 744  QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQ 803

Query: 525  NLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNV-KETIGDLTILNAQLRHGG 583
               + C A  +    +   W  +D  I+ +          V +E I  L IL       G
Sbjct: 804  KKEMSCTAHGEKP--IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861

Query: 584  KYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTL 643
             ++C A            + V+ PP PP  + ++D+   TI L W+ GFD +SPI  Y +
Sbjct: 862  FFSCHAINSYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDI 920

Query: 644  QARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKI 703
            + +          RT   + + N+ T  ++ + P   Y  R+ A N +G  EPS   + I
Sbjct: 921  ECKNKSDSWDSAQRTKDVSPQLNSAT--IIDIHPSSTYSIRMYAKNRIGKSEPSNELT-I 977

Query: 704  RTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQ---GSTHWQT 760
               EAAP   P  +     +   + V W    +  QNG   GY + +R     G+  +  
Sbjct: 978  TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNI 1037

Query: 761  ARVP-GADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV 819
              V    D++  VY+ +++  +T + + +++ NR G GP S   +  + E+ P   P  V
Sbjct: 1038 ISVDTSGDSE--VYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095

Query: 820  WAKGVSSSEMNVTWEPVQQD-MNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGL 878
             A   S   ++++W  + ++ +NGIL G+ + YW         +         S  + GL
Sbjct: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGL 1155

Query: 879  HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDP 934
               T Y + V A+ RAG G  S      T +  P  P G  +   S+S + + W P
Sbjct: 1156 EKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLP 1211



 Score =  165 bits (417), Expect = 2e-40
 Identities = 224/942 (23%), Positives = 363/942 (38%), Gaps = 102/942 (10%)

Query: 29   LGSQTTFGPVFEDQPLSVL--FPEE--STEEQVLLACRARASPPATYRWKMNGTEMKLEP 84
            L +Q     V ED    ++  F E+  S  E V L C  + +P  T  W ++   + L+ 
Sbjct: 392  LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI-LKG 450

Query: 85   GSRH--QLVG--GNLVI---MNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSK 137
            GS    Q++   GN+V    ++ ++ +D GVY+C A+N  G V+ +  I   G     S 
Sbjct: 451  GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG---PASI 507

Query: 138  EERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIART 197
                 + A  G    + C     YP  S +W  N   N +P + R    +  G L ++  
Sbjct: 508  RPMKNITAIAGRDTYIHCRVIG-YPYYSIKWYKNS--NLLPFNHRQVAFENNGTLKLSDV 564

Query: 198  NAS-DLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQ 256
                D G Y+C        ST         +++  +      P    RF       +GQ+
Sbjct: 565  QKEVDEGEYTCNVLVQPQLSTSQ------SVHVTVKVPPFIQPFEFPRFS------IGQR 612

Query: 257  VTLECFAFGNPVP-RIKWRK----VDGSLSPQWTTAEPT--LQIPSVSFEDEGTYECEAE 309
            V + C      +P  I W+K    + GSL       + T  L+I ++S    G Y C A 
Sbjct: 613  VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672

Query: 310  NSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRW-------LR 362
            N       Q ++IV+  P+++    D +   G  +   C+A G P PT+ W       + 
Sbjct: 673  NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP 732

Query: 363  NGEPLASQNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHGT-IYASAELAVQALAPDFR 420
              +P+A   R++VL+ G L    +  EDSG Y C   N  G  +  S  L V+  A    
Sbjct: 733  QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA---M 789

Query: 421  LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEI--------LVNSSRVTVTPDGT 472
            +        A +G +  + C        +V W K   I        LV++  V      T
Sbjct: 790  ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIST 849

Query: 473  LIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGD----NLTL 528
            L I    R D G ++C A N  G+      L+V++       P   +I + D     +TL
Sbjct: 850  LQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE------PPDPPEIEIKDVKARTITL 903

Query: 529  QCHASHDPTMDLTFTWTLDDFPID----FDKPGGHYRRTNVKETIGDLTILNAQLRHGGK 584
            +     D    +T       + I+     D      R  +V   +   TI++        
Sbjct: 904  RWTMGFDGNSPIT------GYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYS 957

Query: 585  YTCMAQTVVDSA--SKEATVLV--RGPPGPPGGVVVRDIGDTTIQLSWS--RGFDNHSPI 638
                A+  +  +  S E T+      P GPP  V +  I   +I+++W   +    +  I
Sbjct: 958  IRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017

Query: 639  AKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSG 698
              Y +  R    G   Q      +  G++E   +  L  +  Y   V A N  GTG PS 
Sbjct: 1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSS 1076

Query: 699  PSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNG--DGFGYL----LSFRR 752
                  T E  PS  P  +     +P  + ++W+ +S+E  NG   GF  +    L    
Sbjct: 1077 QEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGE 1136

Query: 753  QGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEP 812
             G     T   P  +        + +  YT + +++ ++ R GDG  S      + E+ P
Sbjct: 1137 LGEIKNITTTQPSLEL-------DGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP 1189

Query: 813  RVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTS 872
               P  V A   S+S + V+W P  + +NGI+  Y +  + +            +    S
Sbjct: 1190 G-PPAGVKAAAASASMVFVSWLPPLK-LNGIIRKYTV--FCSHPYPTVISEFEASPDSFS 1245

Query: 873  ARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRR 914
             R+  L  N +Y V V A   AG G +S       +   P R
Sbjct: 1246 YRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR 1287



 Score =  154 bits (388), Expect = 5e-37
 Identities = 233/988 (23%), Positives = 373/988 (37%), Gaps = 94/988 (9%)

Query: 55   EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLAS 114
            ++V L C+A   P   YRW  +   M LE   R Q     L+I N  +  D+G Y C  S
Sbjct: 240  QRVELPCKALGHPEPDYRWLKDN--MPLELSGRFQKTVTGLLIEN-IRPSDSGSYVCEVS 296

Query: 115  NPVGTVVSREAILRFGFLQEFSKEERDP--VKAHEGWGVMLPCNPPAHYPGLSYRWLLN- 171
            N  GT      ++   ++++  K    P  VK+  G  V L C+           W  N 
Sbjct: 297  NRYGTA----KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT-EDQELSWYRNG 351

Query: 172  EFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAA 231
            E  N  P            NL +     SD G Y C       F  K   S    + +  
Sbjct: 352  EILN--PGKNVRITGINHENLIMDHMVKSDGGAYQC-------FVRKDKLSAQDYVQVVL 402

Query: 232  EDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP-------QW 284
            ED     P I + F +E      + V+L C   G P+P I W   D  +         Q 
Sbjct: 403  EDG---TPKIISAF-SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQM 458

Query: 285  TTAEPT----LQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADI 340
             T+E      L I S    D G Y C A NS G    Q RI V+  P  ++ + +  A  
Sbjct: 459  ITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIA 517

Query: 341  GSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA--GDLRFSKLSLE-DSGMYQCVA 397
            G +    C   G P  +++W +N   L   +R       G L+ S +  E D G Y C  
Sbjct: 518  GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC-- 575

Query: 398  ENKHGTIYASAELAV-QALAPDFRLNPVRRLIPAAR---GGEILIPCQPRAAPKAVVL-W 452
                  +    +L+  Q++    ++ P  +     R   G  + IPC   +    + + W
Sbjct: 576  -----NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630

Query: 453  SKGTEILVNSSRVTVTP---DGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDAT 509
             K    +  S  VT+       +L I N+S    G YTC A N          L VR   
Sbjct: 631  QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690

Query: 510  KITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETI 569
            K  + P   D   G  + L C A   P   + + ++       F +P     R  V    
Sbjct: 691  KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF-QPIALNGRIQVLSN- 748

Query: 570  GDLTILNAQLRHGGKYTCMAQTVVDS-ASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSW 628
            G L I +      G Y C     V +  SK   + V+ P       ++    +TT+    
Sbjct: 749  GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP------AMITSYPNTTLATQG 802

Query: 629  SRGFDNHSPIAKYTLQARTPPAGKWKQ---------VRTNPANIEGNAETAQVLGLTPWM 679
             +           T     P   +W++          R   +  E   E    L + P +
Sbjct: 803  QK------KEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856

Query: 680  DYEFRVIASNILGT-GEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREY 738
              +    + + + + GE  G      T +  P   P  +         + + WT M  + 
Sbjct: 857  REDSGFFSCHAINSYGEDRGIIQL--TVQEPPD--PPEIEIKDVKARTITLRWT-MGFD- 910

Query: 739  QNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP 798
             N    GY +  + +  +     R      Q    +   + P + + +++ + NR G   
Sbjct: 911  GNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE 970

Query: 799  ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNGILLGYEIRYWK---A 854
             S    + + E  P   P +V  + +SS  + VTW+ P +   NGI+ GY+I Y +    
Sbjct: 971  PSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG 1030

Query: 855  GDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRR 914
            G+ +     V T+G      +  L+  T+Y + V+A NRAGTGP+S     TT++  P  
Sbjct: 1031 GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSY 1090

Query: 915  PPGNI-SWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDL---HLTPTLHL-TGKNWI 969
            PP N+ +   S  S+SI W  +        + G++++Y  +L    L    ++ T +  +
Sbjct: 1091 PPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSL 1150

Query: 970  EIPVPEDIGHALVQIRTTGPGGDGIPAE 997
            E+   E   +  +Q+      GDG+ +E
Sbjct: 1151 ELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178



 Score =  124 bits (310), Expect = 6e-28
 Identities = 155/625 (24%), Positives = 239/625 (38%), Gaps = 70/625 (11%)

Query: 25  WSSALGSQTTFGPVF-EDQPLSVLFPEESTEEQV-------LLACRARASPPATYRWKM- 75
           W  AL    +F  VF ED   S+ F   S +E V       L+ C A   PP T RW + 
Sbjct: 2   WILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLA 61

Query: 76  NGTEMKLEPGSRHQLVGGNLVIMN------PTKAQDAGVYQCLASNPVGTVVSREAILRF 129
            G E+   PG RH    G L I         T   D   Y C A NP G + S++  ++ 
Sbjct: 62  TGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHD-NTYYCTAENPSGKIRSQDVHIKA 120

Query: 130 GFLQEFSKEERDPVKAHEGWGV---MLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVS 186
              + ++    D         V   ++P +  A+   +S+     E        G  F+ 
Sbjct: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSW-----EKDTVSLVSGSRFLI 175

Query: 187 QTTGNLYIARTNASD-LGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARF 245
            +TG LYI      D L NY C+        T+   S      L   D    APSI   F
Sbjct: 176 TSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA----RLFVSDPANSAPSILDGF 231

Query: 246 PAETYALVGQQVTLECFAFGNPVPRIKWRK--VDGSLSPQWTTAEPTLQIPSVSFEDEGT 303
                A+ GQ+V L C A G+P P  +W K  +   LS ++      L I ++   D G+
Sbjct: 232 DHRK-AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGS 290

Query: 304 YECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRN 363
           Y CE  N  G   V GR+ V+   +        ++ +GS +   C+  G     + W RN
Sbjct: 291 YVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRN 350

Query: 364 GEPLASQNRVEVLA---GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFR 420
           GE L     V +      +L    +   D G YQC       +     ++ ++   P   
Sbjct: 351 GEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKII 410

Query: 421 LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILV--NSSRVT--VTPDGTLI-I 475
                +++  A    + + C  +  P   + W+   + ++   S R++  +T +G ++  
Sbjct: 411 SAFSEKVVSPAE--PVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSY 468

Query: 476 RNISRS---DEGKYTCFAEN------FMGKANSTGILSVRDATKITLAPSSADINLGDNL 526
            NIS S   D G Y C A N      +  + N  G  S+R    IT          G + 
Sbjct: 469 LNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI-------AGRDT 521

Query: 527 TLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLR-HGGKY 585
            + C     P   + +    +  P +         R    E  G L + + Q     G+Y
Sbjct: 522 YIHCRVIGYPYYSIKWYKNSNLLPFN--------HRQVAFENNGTLKLSDVQKEVDEGEY 573

Query: 586 TC--MAQTVVDSASKEATVLVRGPP 608
           TC  + Q  + S S+   V V+ PP
Sbjct: 574 TCNVLVQPQL-STSQSVHVTVKVPP 597



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 9/100 (9%)

Query: 255  QQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPS--------VSFEDEGTYEC 306
            + + L C A G+P P +KW K D + +P   T +    I S        V  ED G Y C
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMK-DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359

Query: 307  EAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRW 346
             A N+ G D +   + VQ  P+  ++           L W
Sbjct: 1360 IANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW 1399



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 33/103 (32%), Positives = 50/103 (48%), Gaps = 12/103 (11%)

Query: 435  EILIPCQPRAAPKAVVLWSK---GTEILVN-SSRVTVTPDGTLIIRNISRSDEGKYTCFA 490
            +I++PC+    P   V W K   GT  LV    R ++  +G+ IIR +   D G Y+C A
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361

Query: 491  ENFMGKANSTGILSVR---DATKITLA-PSSADINL----GDN 525
             N  G       L V+   D  ++T++  +S+ I L    GDN
Sbjct: 1362 NNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDN 1404



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 6/76 (7%)

Query: 348  CAAAGKPRPTVRWLR--NGEP--LASQNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHG 402
            C A G P P V+W++  NG P  +    R  + + G      +  EDSG Y C+A N  G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366

Query: 403  TIYASAELAVQALAPD 418
            +      L VQ + PD
Sbjct: 1367 SDEIILNLQVQ-VPPD 1381



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 2/67 (2%)

Query: 55   EQVLLACRARASPPATYRWKM--NGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCL 112
            + ++L C+A   P    +W    NGT   +    R  +      I+   KA+D+G Y C+
Sbjct: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360

Query: 113  ASNPVGT 119
            A+N  G+
Sbjct: 1361 ANNNWGS 1367



 Score = 33.9 bits (76), Expect = 0.82
 Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 4/64 (6%)

Query: 151  VMLPCNPPAHYPGLSYRWLL--NEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208
            ++LPC      P  + +W+   N  P+ +  DGR  +  + G+  I    A D G YSC+
Sbjct: 1303 IVLPCKAVGD-PSPAVKWMKDSNGTPSLVTIDGRRSIF-SNGSFIIRTVKAEDSGYYSCI 1360

Query: 209  ATSH 212
            A ++
Sbjct: 1361 ANNN 1364


>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
          Length = 613

 Score =  226 bits (576), Expect = 9e-59
 Identities = 174/571 (30%), Positives = 251/571 (43%), Gaps = 35/571 (6%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 51  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170

Query: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFSTKSVFSKFAQLN 228
            +       T  +       G+LY +     D+  +YSC A  H   + +   + F    
Sbjct: 171 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK-NPFTLKV 227

Query: 229 LAAEDTRLFAPSIKARFPAETYA----LVGQQVTLECFAFGNPVPRIKWRKVDGSL---S 281
           L         PS    +P  T +    L G  + LEC A G P P I W K  G L    
Sbjct: 228 LTTRGVAERTPSFM--YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 285

Query: 282 PQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQAQPEWLKVISDTEAD 339
            ++      L+I +VS ED G Y C A N  G  R T+  R  V+A P WL    +    
Sbjct: 286 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKAAPYWLDEPKNLILA 343

Query: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRFSKLSLEDSGMYQCV 396
            G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F    +    +YQC 
Sbjct: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403

Query: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-G 455
             N+HG + A+A ++V  + P   L+P  +LI         + C    +P   + W K G
Sbjct: 404 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 462

Query: 456 TEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAP 515
               ++     V  +G+L I+ I + D+G YTC A N +GKA +   L V+D T+I   P
Sbjct: 463 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 522

Query: 516 SSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL 575
                  G  + L+C   HDP++ LT +W  DD P+        Y    +K+    LTI 
Sbjct: 523 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIF 574

Query: 576 NAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606
               R  G YTC+A T +D    +A + V G
Sbjct: 575 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 605



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 92/392 (23%), Positives = 160/392 (40%), Gaps = 41/392 (10%)

Query: 45  SVLFPEESTEEQV-------LLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI 97
           S ++P+ +   Q+       LL C A   P     W   G ++   P  + +    N  +
Sbjct: 239 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKAL 295

Query: 98  -MNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKEERDPVKAHEGWGVMLPC 155
            +     +D+G Y CLASN +G++  R  I +R      +  E ++ + A  G    L C
Sbjct: 296 RITNVSEEDSGEYFCLASNKMGSI--RHTISVRVKAAPYWLDEPKNLILA-PGEDGRLVC 352

Query: 156 NPPAHYPGLSYRWLLNEFP--NFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM 213
               + P  + +W++N  P  +  P   R     T   +    T  S    Y C  ++  
Sbjct: 353 RANGN-PKPTVQWMVNGEPLQSAPPNPNREVAGDT---IIFRDTQISSRAVYQCNTSNEH 408

Query: 214 DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273
            +   + F     +++     R+ +P  +         ++  +  L+C  FG+P+P ++W
Sbjct: 409 GYLLANAF-----VSVLDVPPRMLSPRNQL-----IRVILYNRTRLDCPFFGSPIPTLRW 458

Query: 274 RK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP 327
            K      +DG     +     +L+I  +  ED+G Y C A N  G+   Q R+ V+   
Sbjct: 459 FKNGQGSNLDGGNYHVYENG--SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPT 516

Query: 328 EWLKVISDTEADIGSNLRWGCAAAGKP--RPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385
              ++  D  A  G+ ++  C     P  + TV WL++ EPL   NR++     L    +
Sbjct: 517 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGV 576

Query: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAP 417
           +  D G Y CVA  +     A A L V    P
Sbjct: 577 AERDQGSYTCVASTELDQDLAKAYLTVLGNCP 608



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 88/337 (26%), Positives = 125/337 (37%), Gaps = 59/337 (17%)

Query: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 44  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103

Query: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 159

Query: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTC-----FAENFMG 495
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C     F      
Sbjct: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219

Query: 496 KANST-GILSVRDATKITLA-------PSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547
           K   T  +L+ R   + T +        SS  +  G +L L+C AS  PT D+ +     
Sbjct: 220 KNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGG 279

Query: 548 DFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
           D P D   F+      R TNV E               G+Y C+A   + S     +V V
Sbjct: 280 DLPSDKAKFENFNKALRITNVSE------------EDSGEYFCLASNKMGSIRHTISVRV 327

Query: 605 RG-------------PPGPPGGVVVRDIGDTTIQLSW 628
           +               PG  G +V R  G+    + W
Sbjct: 328 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 364


>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
          Length = 619

 Score =  226 bits (576), Expect = 9e-59
 Identities = 174/571 (30%), Positives = 251/571 (43%), Gaps = 35/571 (6%)

Query: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 57  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116

Query: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176

Query: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFSTKSVFSKFAQLN 228
            +       T  +       G+LY +     D+  +YSC A  H   + +   + F    
Sbjct: 177 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK-NPFTLKV 233

Query: 229 LAAEDTRLFAPSIKARFPAETYA----LVGQQVTLECFAFGNPVPRIKWRKVDGSL---S 281
           L         PS    +P  T +    L G  + LEC A G P P I W K  G L    
Sbjct: 234 LTTRGVAERTPSFM--YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 291

Query: 282 PQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQAQPEWLKVISDTEAD 339
            ++      L+I +VS ED G Y C A N  G  R T+  R  V+A P WL    +    
Sbjct: 292 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKAAPYWLDEPKNLILA 349

Query: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRFSKLSLEDSGMYQCV 396
            G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F    +    +YQC 
Sbjct: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409

Query: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-G 455
             N+HG + A+A ++V  + P   L+P  +LI         + C    +P   + W K G
Sbjct: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468

Query: 456 TEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAP 515
               ++     V  +G+L I+ I + D+G YTC A N +GKA +   L V+D T+I   P
Sbjct: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528

Query: 516 SSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL 575
                  G  + L+C   HDP++ LT +W  DD P+        Y    +K+    LTI 
Sbjct: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIF 580

Query: 576 NAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606
               R  G YTC+A T +D    +A + V G
Sbjct: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 92/392 (23%), Positives = 160/392 (40%), Gaps = 41/392 (10%)

Query: 45  SVLFPEESTEEQV-------LLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI 97
           S ++P+ +   Q+       LL C A   P     W   G ++   P  + +    N  +
Sbjct: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKAL 301

Query: 98  -MNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKEERDPVKAHEGWGVMLPC 155
            +     +D+G Y CLASN +G++  R  I +R      +  E ++ + A  G    L C
Sbjct: 302 RITNVSEEDSGEYFCLASNKMGSI--RHTISVRVKAAPYWLDEPKNLILA-PGEDGRLVC 358

Query: 156 NPPAHYPGLSYRWLLNEFP--NFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM 213
               + P  + +W++N  P  +  P   R     T   +    T  S    Y C  ++  
Sbjct: 359 RANGN-PKPTVQWMVNGEPLQSAPPNPNREVAGDT---IIFRDTQISSRAVYQCNTSNEH 414

Query: 214 DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273
            +   + F     +++     R+ +P  +         ++  +  L+C  FG+P+P ++W
Sbjct: 415 GYLLANAF-----VSVLDVPPRMLSPRNQL-----IRVILYNRTRLDCPFFGSPIPTLRW 464

Query: 274 RK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP 327
            K      +DG     +     +L+I  +  ED+G Y C A N  G+   Q R+ V+   
Sbjct: 465 FKNGQGSNLDGGNYHVYENG--SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPT 522

Query: 328 EWLKVISDTEADIGSNLRWGCAAAGKP--RPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385
              ++  D  A  G+ ++  C     P  + TV WL++ EPL   NR++     L    +
Sbjct: 523 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGV 582

Query: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAP 417
           +  D G Y CVA  +     A A L V    P
Sbjct: 583 AERDQGSYTCVASTELDQDLAKAYLTVLGNCP 614



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 88/337 (26%), Positives = 125/337 (37%), Gaps = 59/337 (17%)

Query: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 50  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109

Query: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 165

Query: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTC-----FAENFMG 495
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C     F      
Sbjct: 166 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 225

Query: 496 KANST-GILSVRDATKITLA-------PSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547
           K   T  +L+ R   + T +        SS  +  G +L L+C AS  PT D+ +     
Sbjct: 226 KNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGG 285

Query: 548 DFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
           D P D   F+      R TNV E               G+Y C+A   + S     +V V
Sbjct: 286 DLPSDKAKFENFNKALRITNVSE------------EDSGEYFCLASNKMGSIRHTISVRV 333

Query: 605 RG-------------PPGPPGGVVVRDIGDTTIQLSW 628
           +               PG  G +V R  G+    + W
Sbjct: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  215 bits (547), Expect = 2e-55
 Identities = 236/956 (24%), Positives = 385/956 (40%), Gaps = 86/956 (8%)

Query: 26   SSALGSQTTFGPVFEDQPLSVLFPEESTE----EQVLLACRARASPPATYRWKMNGTEMK 81
            ++  GS    G +    PL V    +  +      V+L+C    SP  T RW  N TE+ 
Sbjct: 357  TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRN-TELV 415

Query: 82   L--EPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKE 138
            L  E  S   L    L+I +  K+  +G YQC A+    T      I L  G  +  S  
Sbjct: 416  LPDEAISIRGLSNETLLITSAQKSH-SGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF 474

Query: 139  ERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQ-------TTGN 191
                V   E + +M         P  +  W L++ P  I  DG H  +Q       T  +
Sbjct: 475  SEKVVNPGEQFSLMCAAKGA---PPPTVTWALDDEP--IVRDGSHRTNQYTMSDGTTISH 529

Query: 192  LYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYA 251
            + +      D G Y C A + +  +        A++N+         PSI+A       A
Sbjct: 530  MNVTGPQIRDGGVYRCTARNLVGSAEYQ-----ARINVRGP------PSIRAM--RNITA 576

Query: 252  LVGQQVTLECFAFGNPVPRIKWRKVDGSLSP----QWTTAEPTLQIPSVSFE-DEGTYEC 306
            + G+   + C   G P   IKW K D  L P    Q      TL++  V    DEG Y C
Sbjct: 577  VAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC 635

Query: 307  EAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPT-VRWLRNGE 365
                       Q   +    P  ++      A IG  L   C  +    P  + W ++G+
Sbjct: 636  SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQ 695

Query: 366  PLASQNRVEV----LAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRL 421
             + S + V +        L+ S +SL+ +G Y C+A N   T+    +L V+ + P F +
Sbjct: 696  VIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR-VPPRFVV 754

Query: 422  NPVRRLIPAARGGEILIPCQPRAAPKAVVLW--SKGT------EILVNSSRVTVTPDGTL 473
             P  +     + G  ++ C     P   V+W  +KG+        +  + R+ + P+ +L
Sbjct: 755  QPNNQDGIYGKAG--VLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSL 812

Query: 474  IIRNISRSDEGKYTCFAENFMGKANSTGI-LSVRDATKITLAPSSADINLGDNLTLQCHA 532
            +IR++   D G Y C A N +G   S  + L+V+    IT  P++     G    L C A
Sbjct: 813  LIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTA 872

Query: 533  SHDPTMDLTFTWTLDDFPIDFDKPGGHYRRT--NVKETIGDLTILNAQLRHGGKYTCMAQ 590
              +    +   W   D  ID D+   +   T  N  E +  L +  A       ++C A 
Sbjct: 873  RGE--RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAI 930

Query: 591  TVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPA 650
                       + V+ PP PP  + +R++   ++ L W++ FD +S I  + ++ +   +
Sbjct: 931  NSYGEDRGLIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNK-S 988

Query: 651  GKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAP 710
              W   + +  NI      A ++ L P   Y  R+ + N +G  EPS   + I T EAAP
Sbjct: 989  DSW-DFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELT-ISTEEAAP 1046

Query: 711  SVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQY 770
               P  ++        + V W    +E QNG   GY + +R            PG++ QY
Sbjct: 1047 DGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENS---------PGSNGQY 1097

Query: 771  F-----------VYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV 819
                        VY+ ++++ +  + V ++++NR G GP S      + E+ P   P  V
Sbjct: 1098 SIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENV 1157

Query: 820  WAKGVSSSEMNVTW-EPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGL 878
             A  ++S    ++W EP +  +NG+L GY + +W         +            + G+
Sbjct: 1158 RALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGM 1217

Query: 879  HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDP 934
               T Y V V AY +AG G  S      T +  P  P G  +   S+SS+ + W P
Sbjct: 1218 EKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLP 1273



 Score =  156 bits (395), Expect = 8e-38
 Identities = 226/1004 (22%), Positives = 383/1004 (38%), Gaps = 127/1004 (12%)

Query: 57   VLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNP 116
            V L C A   P    RW  +G  +  +     ++ G   + ++  + +D+G Y C  +N 
Sbjct: 303  VELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITG---LTISDLRTEDSGTYICEVTNT 359

Query: 117  VGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNF 176
             G+  +   ++    L      ++  +K   G  V+L C      P  + RW  N     
Sbjct: 360  FGSAEATGILMVIDPLHVTLTPKK--LKTGIGSTVILSCALTGS-PEFTIRWYRNT-ELV 415

Query: 177  IPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRL 236
            +P +       +   L I     S  G Y C AT     +            +A ED   
Sbjct: 416  LPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAI-------IALEDG-- 466

Query: 237  FAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSL-------SPQWTTAEP 289
              P I + F +E     G+Q +L C A G P P + W   D  +       + Q+T ++ 
Sbjct: 467  -TPRIVSSF-SEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDG 524

Query: 290  T----LQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLR 345
            T    + +      D G Y C A N  G    Q RI V+  P  ++ + +  A  G +  
Sbjct: 525  TTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPS-IRAMRNITAVAGRDTL 583

Query: 346  WGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA-GDLRFSKLSLE-DSGMYQC-VAENKHG 402
              C   G P  +++W ++   L   +R  V   G L+ + +    D G Y C V      
Sbjct: 584  INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643

Query: 403  TIYASAELAVQA--LAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAV-VLWSKGTEIL 459
            +I  S  +AV+   L   F   P      A+ G  + IPC   +    + + W K  +++
Sbjct: 644  SISQSVHVAVKVPPLIQPFEFPP------ASIGQLLYIPCVVSSGDMPIRITWRKDGQVI 697

Query: 460  VNSSRVTVTPD---GTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPS 516
            ++ S VT+       +L I ++S    G YTC A N     +    L VR   +  + P+
Sbjct: 698  ISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPN 757

Query: 517  SADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL- 575
            + D   G    L C     P   + +            K  G+ ++ +     G + IL 
Sbjct: 758  NQDGIYGKAGVLNCSVDGYPPPKVMWKHA---------KGSGNPQQYHPVPLTGRIQILP 808

Query: 576  --NAQLRHG-----GKYTCMAQTVVDS-ASKEATVLVRGPPGPPGGVVVRDIGDTTIQLS 627
              +  +RH      G Y C A   V +  SK   + V+ P       ++    +TTI + 
Sbjct: 809  NSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIP------AMITSHPNTTIAIK 862

Query: 628  WSRGFDNHSPIAKYTLQARTPPAGKWKQ----------VRTNPANIEGNAETAQVLGLTP 677
                   H+     T +   P   +W++          +R   A  +   E    L L P
Sbjct: 863  ------GHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKP 916

Query: 678  WMDYE---FRVIASNILGTGE----------PSGPSSKIRTREAAPSVAPSGLSGGGGAP 724
                +   F   A N  G             P  P  +IR  +A        L       
Sbjct: 917  ADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSM----NLRWTQRFD 972

Query: 725  GELIVNWTPMSREYQN-GDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTP 783
            G  I+  T    EY+N  D + +  S R    T  Q   V              + P + 
Sbjct: 973  GNSII--TGFDIEYKNKSDSWDFKQSTRNISPTINQANIV-------------DLHPASV 1017

Query: 784  FEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNG 842
            + +++ S+N+ G    S    + + E  P   P  V  + V+S  + VTW+ P ++  NG
Sbjct: 1018 YSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG 1077

Query: 843  ILLGYEIRYWK---AGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPA 899
            ++ GY+I Y +     + + +   ++  G      +  L    +Y V V+A+NRAGTGP+
Sbjct: 1078 VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPS 1137

Query: 900  SPSANATTMKPPPRRPPGNI-SWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQN---DL 955
            S   NATT++  P +PP N+ + + +S    I W           + GY++++ +   D 
Sbjct: 1138 SSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDG 1197

Query: 956  HLTPTLHL-TGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEV 998
                  ++ T +  +E+   E   +  VQ+      GDG+ + V
Sbjct: 1198 EWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSV 1241



 Score =  143 bits (361), Expect = 7e-34
 Identities = 136/489 (27%), Positives = 208/489 (42%), Gaps = 54/489 (11%)

Query: 150 GVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDG-RHFVSQTTGNLYIARTNASDL----GN 204
           GV++PC P A  P  + RW L    +       RH  +  T  LY    +A +      +
Sbjct: 102 GVVVPC-PAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND 160

Query: 205 YSCLATSHM------DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVT 258
           Y C A +        +   K+VF +     +  ED R    ++ A F     + V + V+
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFRE--PYTVRVEDQRSMRGNV-AVFKCLIPSSVQEYVS 217

Query: 259 LECFAFGNPVPRIKWRKVDGSLSPQ---WTTAEPTLQIPSVSFEDE-GTYECEAENSKGR 314
           +           + W K   S+ P+   + T    L I  V  ED   TY C  ++    
Sbjct: 218 V-----------VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSG 266

Query: 315 DTVQG---RIIVQAQPEWLKVISD----TEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL 367
           +T Q    R+ V    E +  I D     E   G  +   C A+G P P +RWL++G PL
Sbjct: 267 ETRQSNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPL 326

Query: 368 ASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRL 427
            + +R       L  S L  EDSG Y C   N  G+  A+  L V        +    + 
Sbjct: 327 PADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKK 383

Query: 428 IPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTV--TPDGTLIIRNISRSDEGK 485
           +    G  +++ C    +P+  + W + TE+++    +++    + TL+I +  +S  G 
Sbjct: 384 LKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGA 443

Query: 486 YTCFAENFMGKANSTGILSVRDAT-KITLAPSSADINLGDNLTLQCHASHDPTMDLTFTW 544
           Y CFA      A    I+++ D T +I  + S   +N G+  +L C A   P    T TW
Sbjct: 444 YQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPP--TVTW 501

Query: 545 TLDDFPIDFDKPGGHYRRTNV-----KETIGDLTILNAQLRHGGKYTCMAQTVVDSASKE 599
            LDD PI  D  G H  RTN        TI  + +   Q+R GG Y C A+ +V SA  +
Sbjct: 502 ALDDEPIVRD--GSH--RTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ 557

Query: 600 ATVLVRGPP 608
           A + VRGPP
Sbjct: 558 ARINVRGPP 566



 Score =  140 bits (352), Expect = 8e-33
 Identities = 207/916 (22%), Positives = 339/916 (37%), Gaps = 120/916 (13%)

Query: 93   GNLVIMNPTKAQDAGVYQCLASNPVG--TVVSREAILRFGFLQEFSKEERDPVKAHEGWG 150
            G L I +  K      Y+C+  +     T  S  A L      E      D   + E W 
Sbjct: 240  GGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWA 299

Query: 151  ---VMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSC 207
               V LPC     YP  + RWL +  P  +P D R +  + TG L I+     D G Y C
Sbjct: 300  GHTVELPCTASG-YPIPAIRWLKDGRP--LPADSR-WTKRITG-LTISDLRTEDSGTYIC 354

Query: 208  LATSHMDFSTKSVFSKFAQLNLAAEDTRLFA---PSIKARFPAETYALVGQQVTLECFAF 264
              T+                  +AE T +     P      P +    +G  V L C   
Sbjct: 355  EVTNTFG---------------SAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALT 399

Query: 265  GNPVPRIKWRK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQ 318
            G+P   I+W +       D ++S +  + E TL I S      G Y+C A  ++   T Q
Sbjct: 400  GSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA--TRKAQTAQ 456

Query: 319  GRIIVQAQ---PEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ----- 370
               I+  +   P  +   S+   + G      CAA G P PTV W  + EP+        
Sbjct: 457  DFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT 516

Query: 371  NRVEVLAGD----LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRR 426
            N+  +  G     +  +   + D G+Y+C A N  G+    A + V+   P  R     R
Sbjct: 517  NQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRG-PPSIR---AMR 572

Query: 427  LIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRS-DEGK 485
             I A  G + LI C+    P   + W K   +L ++ R  V  +GTL + ++ +  DEG+
Sbjct: 573  NITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632

Query: 486  YTCFAENFMGKANSTGILSVRDATKITLAPSSADI---NLGDNLTLQCHASHDPTMDLTF 542
            Y C   + + +   +   SV  A K+       +    ++G  L + C  S    M +  
Sbjct: 633  YLC---SVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD-MPIRI 688

Query: 543  TWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATV 602
            TW  D   I      G       KE +  L I +  L+H G YTC+A     + S+E  +
Sbjct: 689  TWRKDGQVII----SGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQL 744

Query: 603  LVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVR--TNP 660
            +VR PP               +Q +   G    + +   ++    PP   WK  +   NP
Sbjct: 745  IVRVPP------------RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNP 792

Query: 661  ANIEGNAETAQVLGLTPWMDYEFRVI-----------ASNILGTGEPSGPSSKIR----- 704
                    T ++  + P      R +           ASN +GT         ++     
Sbjct: 793  QQYHPVPLTGRI-QILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMI 851

Query: 705  TREAAPSVAPSG----LSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQT 760
            T     ++A  G    L+        +I+ W              Y ++ +  G     T
Sbjct: 852  TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVST 911

Query: 761  ARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVW 820
             ++  AD    V+ +            I SY       E    +  + +E P   P ++ 
Sbjct: 912  LKLKPADRGDSVFFSCHA---------INSYG------EDRGLIQLTVQEPP--DPPELE 954

Query: 821  AKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRT-AGLDTSARVSGLH 879
             + V +  MN+ W   + D N I+ G++I Y    D        R  +     A +  LH
Sbjct: 955  IREVKARSMNLRWTQ-RFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLH 1013

Query: 880  PNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNIS-WTFSSSSLSIKWDPVVPF 938
            P + Y + + ++N+ G    S     +T +  P  PP +++    +S S+ + W      
Sbjct: 1014 PASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKE 1073

Query: 939  RNESAVTGYKMLYQND 954
                 + GY++ Y+ +
Sbjct: 1074 LQNGVIRGYQIGYREN 1089



 Score =  119 bits (297), Expect = 2e-26
 Identities = 160/634 (25%), Positives = 250/634 (39%), Gaps = 63/634 (9%)

Query: 40  EDQPLSVLFPEESTEEQ-------VLLACRARASPPATYRWKM-NGTEMKLEPGSRHQLV 91
           ED   S+ F  +S ++        V++ C A  SP A  RW +  G ++   P  RH   
Sbjct: 79  EDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWYLATGDDIYDVPHIRHVHA 138

Query: 92  GGNLVI--MNPTKAQD---AGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAH 146
            G L +   +P+          Y C A N  G + S    ++  F + ++    D     
Sbjct: 139 NGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMR 198

Query: 147 EGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASD-LGNY 205
               V     P +    +S      +  + IP + R F++   G LYI+     D L  Y
Sbjct: 199 GNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIP-EHRFFITY-HGGLYISDVQKEDALSTY 256

Query: 206 SCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFG 265
            C+ T H  +S ++  S  A+L++   D     P+I   F ++     G  V L C A G
Sbjct: 257 RCI-TKH-KYSGETRQSNGARLSVT--DPAESIPTILDGFHSQE-VWAGHTVELPCTASG 311

Query: 266 NPVPRIKWRKVDGSLSP---QWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRII 322
            P+P I+W K DG   P   +WT     L I  +  ED GTY CE  N+ G     G ++
Sbjct: 312 YPIPAIRWLK-DGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILM 370

Query: 323 VQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEV--LAGD- 379
           V             +  IGS +   CA  G P  T+RW RN E +     + +  L+ + 
Sbjct: 371 VIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNET 430

Query: 380 LRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIP 439
           L  +      SG YQC A  K  T    A +A++   P    +   +++    G +  + 
Sbjct: 431 LLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNP--GEQFSLM 488

Query: 440 CQPRAAPKAVVLWSKGTEILV-----NSSRVTVTPDGTLIIRNISR---SDEGKYTCFAE 491
           C  + AP   V W+   E +V      +++ T++   T+   N++     D G Y C A 
Sbjct: 489 CAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548

Query: 492 NFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPI 551
           N +G A     ++VR    I  A  +     G +  + C     P   +   W  D   +
Sbjct: 549 NLVGSAEYQARINVRGPPSIR-AMRNITAVAGRDTLINCRVIGYPYYSI--KWYKDALLL 605

Query: 552 DFDKPGGHYRRTNVKETIGDLTILNAQL-RHGGKYTCMAQTVVD-SASKEATVLVRGPP- 608
               P  H  R  V E  G L + + Q     G+Y C        S S+   V V+ PP 
Sbjct: 606 ----PDNH--RQVVFEN-GTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPL 658

Query: 609 -----GPPGGV-------VVRDIGDTTIQLSWSR 630
                 PP  +        V   GD  I+++W +
Sbjct: 659 IQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK 692



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 82/349 (23%), Positives = 136/349 (38%), Gaps = 60/349 (17%)

Query: 475  IRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLT------- 527
            I +++R  +      A    G+ NS+  +++  A K   AP+   I+ G  +T       
Sbjct: 1312 IAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGK---APAKI-ISFGGTVTTPWMKDV 1367

Query: 528  -LQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYT 586
             L C++  DP   + +T   +D  I     G     TN     G L +   +    G YT
Sbjct: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTN-----GTLLLRAVKAEDSGYYT 1422

Query: 587  CMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQAR 646
            C A       +    +LV+ PP  P  + V     ++I L+W  G +  S I  + LQ  
Sbjct: 1423 CTATNTGGFDTIIVNLLVQVPPDQPR-LTVSKTSASSITLTWIPGDNGGSSIRGFVLQYS 1481

Query: 647  TPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG------------ 694
               + +WK V      I  +  + ++  L     Y+ ++ A N +G+G            
Sbjct: 1482 VDNSEEWKDV-----FISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHG 1536

Query: 695  -EPSGPSSKIRTREAAPSVAPSGLSG--GGGAPGELIVNWTPMSREYQNGDGFGYLLSFR 751
             EPS    +        + A   L G   GG P   IV                  L +R
Sbjct: 1537 REPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIV------------------LEYR 1578

Query: 752  RQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPES 800
             +G+  WQ  R   A++   V+  E +R  T +E+++R+ N  G G E+
Sbjct: 1579 PKGTWAWQGLR---ANSSGEVFLTE-LREATWYELRMRACNSAGCGNET 1623



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 7/99 (7%)

Query: 255  QQVTLECFAFGNPVPRIKWRK-VDGSLSP------QWTTAEPTLQIPSVSFEDEGTYECE 307
            + V L C + G+P P +KW K  + S  P      +      TL + +V  ED G Y C 
Sbjct: 1365 KDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424

Query: 308  AENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRW 346
            A N+ G DT+   ++VQ  P+  ++     +     L W
Sbjct: 1425 ATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTW 1463



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 69/282 (24%), Positives = 108/282 (38%), Gaps = 49/282 (17%)

Query: 435  EILIPCQPRAAPKAVVLWSKGTE-----ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCF 489
            ++ +PC     P   V W+K +E     + ++  R+  T +GTL++R +   D G YTC 
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCT 1424

Query: 490  AENFMGKANSTGILSVR---DATKITLAPSSA-DINL----GDN-------LTLQCHASH 534
            A N  G       L V+   D  ++T++ +SA  I L    GDN         LQ    +
Sbjct: 1425 ATNTGGFDTIIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDN 1484

Query: 535  -DPTMDLTFTWTLDDFPIDFDKPGGHYR-RTNVKETIGDLTILNAQLRHGGKYTCMAQTV 592
             +   D+  + +   F +D  K G  Y+ +   K ++G   I                  
Sbjct: 1485 SEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRI------------------ 1526

Query: 593  VDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGK 652
              S   EA    R P       +   I  T  +L+     +   PI    L+ R      
Sbjct: 1527 --SEIIEAKTHGREPSFSKDQHLFTHINSTHARLNLQGWNNGGCPITAIVLEYRPKGTWA 1584

Query: 653  WKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG 694
            W+ +R   AN  G     ++   T W  YE R+ A N  G G
Sbjct: 1585 WQGLR---ANSSGEVFLTELREAT-W--YELRMRACNSAGCG 1620



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 6/81 (7%)

Query: 343  NLRWGCAAAGKPRPTVRWLRNGEPLA-----SQNRVEVLAGDLRFSKLSLEDSGMYQCVA 397
            ++R  C + G P P V+W ++ E  A       +R+    G L    +  EDSG Y C A
Sbjct: 1366 DVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTA 1425

Query: 398  ENKHGTIYASAELAVQALAPD 418
             N  G       L VQ + PD
Sbjct: 1426 TNTGGFDTIIVNLLVQ-VPPD 1445



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 4/69 (5%)

Query: 151  VMLPCNPPAHYPGLSYRWLLNEFPNFIPT--DGRHFVSQTTGNLYIARTNASDLGNYSCL 208
            V LPCN     P  + +W  +   + IP   DG H +  T G L +    A D G Y+C 
Sbjct: 1367 VRLPCNSVGD-PAPAVKWTKDSEDSAIPVSMDG-HRLIHTNGTLLLRAVKAEDSGYYTCT 1424

Query: 209  ATSHMDFST 217
            AT+   F T
Sbjct: 1425 ATNTGGFDT 1433



 Score = 34.3 bits (77), Expect = 0.63
 Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 9/118 (7%)

Query: 6    RRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTE---EQVLLACR 62
            R + +LL VAAV    +SA       + T  P  +     + F    T    + V L C 
Sbjct: 1317 RGQQYLLWVAAV----TSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCN 1372

Query: 63   ARASPPATYRWKMNGTEMKLEPG-SRHQLVGGN-LVIMNPTKAQDAGVYQCLASNPVG 118
            +   P    +W  +  +  +      H+L+  N  +++   KA+D+G Y C A+N  G
Sbjct: 1373 SVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430


>gi|28373124 contactin 4 isoform b precursor [Homo sapiens]
          Length = 282

 Score =  212 bits (540), Expect = 1e-54
 Identities = 100/240 (41%), Positives = 151/240 (62%), Gaps = 1/240 (0%)

Query: 758 WQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPT 817
           W    +  ADA  +V+ NESV P++PFEVK+  +N +G+GP S T +VYSAEEEP   P 
Sbjct: 3   WMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPA 62

Query: 818 KVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSG 877
            ++A+ +S++++ V W    +   G + GYE++YW+  DKE  A ++RT G  TS +++ 
Sbjct: 63  SIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITN 122

Query: 878 LHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVP 937
           L  +  YH+ V+AYN AGTGP+S + N TT KPPP +PPGNI W  S S + + WD V  
Sbjct: 123 LKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKA 182

Query: 938 FRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAE 997
             NES V GYK+LY+ +   + ++  T K  +E+ +P D  + +++I+    GGDG  +E
Sbjct: 183 LDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDY-IIEIKPFSDGGDGSSSE 241



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 60/251 (23%), Positives = 100/251 (39%), Gaps = 47/251 (18%)

Query: 591 TVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPA 650
           TVV SA +E       P  PP  +  R +  T I++ W+      SP+ K   + +    
Sbjct: 48  TVVYSAEEE-------PTKPPASIFARSLSATDIEVFWA------SPLEKNRGRIQGYEV 94

Query: 651 GKW----KQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTR 706
             W    K+         GN  + ++  L   + Y   V A N  GTG PS  +  + TR
Sbjct: 95  KYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG-PSSATVNVTTR 153

Query: 707 EAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFR--RQGSTHWQTARVP 764
           +  PS  P  +     +  ++I+NW  +       +  GY + +R  RQ ST        
Sbjct: 154 KPPPSQPPGNII-WNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSST-------- 204

Query: 765 GADAQYFVYSNESVRPYTPFE----VKIRSYNRRGDGPESLTALVYSAEEEPRVAP-TKV 819
                    +  SV    PF+    ++I+ ++  GDG         S+ E+ R+   +  
Sbjct: 205 ----SVIETNKTSVELSLPFDEDYIIEIKPFSDGGDG---------SSSEQIRIPKISNA 251

Query: 820 WAKGVSSSEMN 830
           +A+G  +S  N
Sbjct: 252 YARGSGASTSN 262



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 8/105 (7%)

Query: 568 TIGDLTILNAQLRHGGKYTCMAQTVVDSAS---KEATVLV---RGPPGPPGGVVVRDIGD 621
           T+G+ T        G     +A    +SA      ATV V   + PP  P G ++ +  D
Sbjct: 111 TVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSD 170

Query: 622 TTIQLSWS--RGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIE 664
           + I L+W   +  DN S +  Y +  R         + TN  ++E
Sbjct: 171 SKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVE 215


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  203 bits (516), Expect = 8e-52
 Identities = 211/769 (27%), Positives = 328/769 (42%), Gaps = 105/769 (13%)

Query: 196 RTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAA--EDTRLFAPSIKARFPAETYALV 253
           R +  D G+Y C+A +++        S+ A L +A   +D R        + P +     
Sbjct: 115 RRSKPDEGSYVCVARNYLG----EAVSRNASLEVALLRDDFR--------QNPTDVVVAA 162

Query: 254 GQQVTLECFA-FGNPVPRIKWRK----VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEA 308
           G+   LEC    G+P P I W+K    +D     + +     L I +    D G Y C  
Sbjct: 163 GEPAILECQPPRGHPEPTIYWKKDKVRIDDK-EERISIRGGKLMISNTRKSDAGMYTCVG 221

Query: 309 ENSKG-RDTVQGRIIVQAQPEWLK-----VISDTEADIGSNLRWGCAAAGKPRPTVRWLR 362
            N  G RD+    + V  +P +L+     V+ + EA     + + C   G P+PTVRW +
Sbjct: 222 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEA-----VEFRCQVQGDPQPTVRWKK 276

Query: 363 NGEPLASQNRVEVLAG-DLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRL 421
           +   L  + R ++     LR  K    D G Y C+AEN+ G + ASA L V+A  P F +
Sbjct: 277 DDADLP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA-PPQFVV 334

Query: 422 NPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-GTEILV-------NSSRVTVTPDGTL 473
            P  +++  A+G  +  PC+ +  P+  V W K G++ L+        +SR +V+P G L
Sbjct: 335 RPRDQIV--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 392

Query: 474 IIRNISRSDEGKYTCFAENFMG------KANSTGILSVRDATKITLAPSSADINLGDNLT 527
            I NI RSD G Y C A    G      +   T +L+ R    I   P++  + +     
Sbjct: 393 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL 452

Query: 528 LQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
           L+C A+ DP      +W  + F      PG   R T  ++  G L I N ++   G YTC
Sbjct: 453 LKCKATGDPLP--VISWLKEGFTF----PGRDPRATIQEQ--GTLQIKNLRISDTGTYTC 504

Query: 588 MAQT---------VVDSASKEATVL----VRGPPGPPGGVVVRDIGDTTIQLSWSRGFDN 634
           +A +         V+D     AT+     +   PGPP    V D+   ++ LSW  G   
Sbjct: 505 VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPG 564

Query: 635 HSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG 694
             P + Y ++A +       Q   N  +++    T  V GL P   Y F V A N  G  
Sbjct: 565 TLPASAYIIEAFSQSVSNSWQTVAN--HVKTTLYT--VRGLRPNTIYLFMVRAINPQGLS 620

Query: 695 EPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVN---------------WTPMSREYQ 739
           +PS  S  +RT++ +P              G+++V                WT + R+ Q
Sbjct: 621 DPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT-VDRQPQ 679

Query: 740 NGDGFG--YLLSFRRQGSTHWQT--ARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRG 795
              G+   Y  +   Q ++ WQ   A+VP   +   V   + V     +E+K+R Y    
Sbjct: 680 FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVT----YEIKVRPYFNEF 735

Query: 796 DGPESLTALVYSAEEEPRVAPTKVWAKGV---SSSEMNVTWEPVQQD-MNGILLGYEIRY 851
            G +S +  V + EE P   P  V    V   +S+ ++V+W+P   D  NGI+  Y+I  
Sbjct: 736 QGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-- 793

Query: 852 WKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900
           W  G++              S  + GL P  +Y V V A   AG G  S
Sbjct: 794 WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 842



 Score =  169 bits (429), Expect = 1e-41
 Identities = 200/776 (25%), Positives = 306/776 (39%), Gaps = 97/776 (12%)

Query: 32  QTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEM---KLEPGSRH 88
           Q  F P   + P  V+    S  E   L C+A   P  T  W  +G  +   K +P S  
Sbjct: 42  QEDFPPRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR 98

Query: 89  QLV-GGNL----VIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPV 143
            L+  G+L    ++       D G Y C+A N +G  VSR A L    L++  ++    V
Sbjct: 99  MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV 158

Query: 144 KAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG 203
               G   +L C PP  +P  +  W  ++       D    +S   G L I+ T  SD G
Sbjct: 159 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRI---DDKEERISIRGGKLMISNTRKSDAG 215

Query: 204 NYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFA 263
            Y+C+ T+ +        S  A+L +    T L       R P     L  + V   C  
Sbjct: 216 MYTCVGTNMVGERD----SDPAELTVFERPTFL-------RRPINQVVLEEEAVEFRCQV 264

Query: 264 FGNPVPRIKWRKVDGSLSPQWTTAEP--TLQIPSVSFEDEGTYECEAENSKGRDTVQGRI 321
            G+P P ++W+K D  L       +   TL+I      DEGTY C AEN  G+      +
Sbjct: 265 QGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 324

Query: 322 IVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG--------EPLASQNRV 373
            V+A P+++    D     G  + + C   G P+P V W + G        +P    +R 
Sbjct: 325 TVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRC 384

Query: 374 EVL-AGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPA-- 430
            V   GDL  + +   D+G Y C A    G+I A A+L V  +  D R  P+    PA  
Sbjct: 385 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTD-RPPPIILQGPANQ 443

Query: 431 --ARGGEILIPCQPRAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYT 487
             A  G  L+ C+    P  V+ W K G        R T+   GTL I+N+  SD G YT
Sbjct: 444 TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 503

Query: 488 CFAENFMGKANSTGILSVR----------DATKITLAPSSADIN--LGDNLTLQCHASHD 535
           C A +  G+ + + +L V           D + +   PS   +     +++TL       
Sbjct: 504 CVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTP 563

Query: 536 PTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMA-----Q 590
            T+  +  + ++ F              +VK T+  +      LR    Y  M      Q
Sbjct: 564 GTLPAS-AYIIEAFSQSVSN-SWQTVANHVKTTLYTV----RGLRPNTIYLFMVRAINPQ 617

Query: 591 TVVDSASKEATVLVRGPPGPPGGV----VVRDIGD-------------TTIQLSWSRGFD 633
            + D +     V  +    P  GV    V +++GD             TT+Q++W+    
Sbjct: 618 GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT---V 674

Query: 634 NHSP--IAKYTLQARTPPAGKWKQVRTNPANIEGNAET---AQVLGLTPWMDYEFRVIAS 688
           +  P  I  Y +  R        Q  ++  N++    T   A ++ L   + YE +V   
Sbjct: 675 DRQPQFIQGYRVMYRQTSG---LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPY 731

Query: 689 NILGTGEPSGPSSKIRTREAAPSVAPSG---LSGGGGAPGELIVNWTPMSREYQNG 741
                G  S  S  +RT E APS  P     L+ G      + V+W P   ++QNG
Sbjct: 732 FNEFQGMDS-ESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNG 786



 Score =  147 bits (372), Expect = 4e-35
 Identities = 199/795 (25%), Positives = 304/795 (38%), Gaps = 128/795 (16%)

Query: 237 FAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAEPTLQIP 294
           F P I    P++     G+  TL C A G P P I+W K DG    + +       + +P
Sbjct: 45  FPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLP 102

Query: 295 SVSF------------EDEGTYECEAENSKGRDTVQGRIIVQA--QPEWLKVISDTEADI 340
           S S              DEG+Y C A N  G    +   +  A  + ++ +  +D     
Sbjct: 103 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 162

Query: 341 GSNLRWGCAAA-GKPRPTVRWLRNGEPLAS-QNRVEVLAGDLRFSKLSLEDSGMYQCVAE 398
           G      C    G P PT+ W ++   +   + R+ +  G L  S     D+GMY CV  
Sbjct: 163 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT 222

Query: 399 NKHGTIYAS-AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTE 457
           N  G   +  AEL V    P F   P+ +++      E    CQ +  P+  V W K   
Sbjct: 223 NMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVEFR--CQVQGDPQPTVRWKKDDA 279

Query: 458 ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSS 517
            L    R  +  D TL I+    +DEG Y C AEN +GK  ++  L+VR   +  + P  
Sbjct: 280 DLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRD 338

Query: 518 ADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNA 577
             +  G  +T  C    +P   + +        +  ++P     R +V  T GDLTI N 
Sbjct: 339 QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT-GDLTITNI 397

Query: 578 QLRHGGKYTCMAQTVVDS----ASKEAT-VLVRGPP-----GPPGGVVVRD--------- 618
           Q    G Y C A TV  S    A  E T VL   PP     GP    +  D         
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 457

Query: 619 IGDTTIQLSWSR------GFDNHSPIAKY-TLQ---ARTPPAGKWKQVRTNPANIEGNAE 668
            GD    +SW +      G D  + I +  TLQ    R    G +  V T+ +   G   
Sbjct: 458 TGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS---GETS 514

Query: 669 TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELI 728
            + VL +T     E     S      +  GP SK +  +   +     LS   G PG L 
Sbjct: 515 WSAVLDVT-----ESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT--LSWQPGTPGTL- 566

Query: 729 VNWTPMSREYQNGDGFGYLL-SFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVK 787
               P S          Y++ +F +  S  WQT        +  +Y+   +RP T +   
Sbjct: 567 ----PAS---------AYIIEAFSQSVSNSWQTV---ANHVKTTLYTVRGLRPNTIYLFM 610

Query: 788 IRSYNRRG-DGPESLTALVYSAEEEPRVAPTKVWAKGV---------------------- 824
           +R+ N +G   P  ++  V + +  P        A+GV                      
Sbjct: 611 VRAINPQGLSDPSPMSDPVRTQDISPP-------AQGVDHRQVQKELGDVLVRLHNPVVL 663

Query: 825 SSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAAD------RVRTAGLDTSARVSGL 878
           + + + VTW   +Q     + GY + Y +    +A +       +V T   + SA +  L
Sbjct: 664 TPTTVQVTWTVDRQPQ--FIQGYRVMYRQTSGLQATSSWQNLDAKVPT---ERSAVLVNL 718

Query: 879 HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNIS----WTFSSSSLSIKWDP 934
                Y + VR Y     G  S S    T +  P  PP +++     +++S+S+S+ WDP
Sbjct: 719 KKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDP 778

Query: 935 VVPFRNESAVTGYKM 949
             P      +  YK+
Sbjct: 779 PPPDHQNGIIQEYKI 793


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  203 bits (516), Expect = 8e-52
 Identities = 211/769 (27%), Positives = 328/769 (42%), Gaps = 105/769 (13%)

Query: 196 RTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAA--EDTRLFAPSIKARFPAETYALV 253
           R +  D G+Y C+A +++        S+ A L +A   +D R        + P +     
Sbjct: 99  RRSKPDEGSYVCVARNYLG----EAVSRNASLEVALLRDDFR--------QNPTDVVVAA 146

Query: 254 GQQVTLECFA-FGNPVPRIKWRK----VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEA 308
           G+   LEC    G+P P I W+K    +D     + +     L I +    D G Y C  
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDK-EERISIRGGKLMISNTRKSDAGMYTCVG 205

Query: 309 ENSKG-RDTVQGRIIVQAQPEWLK-----VISDTEADIGSNLRWGCAAAGKPRPTVRWLR 362
            N  G RD+    + V  +P +L+     V+ + EA     + + C   G P+PTVRW +
Sbjct: 206 TNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEA-----VEFRCQVQGDPQPTVRWKK 260

Query: 363 NGEPLASQNRVEVLAG-DLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRL 421
           +   L  + R ++     LR  K    D G Y C+AEN+ G + ASA L V+A  P F +
Sbjct: 261 DDADLP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA-PPQFVV 318

Query: 422 NPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-GTEILV-------NSSRVTVTPDGTL 473
            P  +++  A+G  +  PC+ +  P+  V W K G++ L+        +SR +V+P G L
Sbjct: 319 RPRDQIV--AQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 376

Query: 474 IIRNISRSDEGKYTCFAENFMG------KANSTGILSVRDATKITLAPSSADINLGDNLT 527
            I NI RSD G Y C A    G      +   T +L+ R    I   P++  + +     
Sbjct: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTAL 436

Query: 528 LQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTC 587
           L+C A+ DP      +W  + F      PG   R T  ++  G L I N ++   G YTC
Sbjct: 437 LKCKATGDPLP--VISWLKEGFTF----PGRDPRATIQEQ--GTLQIKNLRISDTGTYTC 488

Query: 588 MAQT---------VVDSASKEATVL----VRGPPGPPGGVVVRDIGDTTIQLSWSRGFDN 634
           +A +         V+D     AT+     +   PGPP    V D+   ++ LSW  G   
Sbjct: 489 VATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPG 548

Query: 635 HSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTG 694
             P + Y ++A +       Q   N  +++    T  V GL P   Y F V A N  G  
Sbjct: 549 TLPASAYIIEAFSQSVSNSWQTVAN--HVKTTLYT--VRGLRPNTIYLFMVRAINPQGLS 604

Query: 695 EPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVN---------------WTPMSREYQ 739
           +PS  S  +RT++ +P              G+++V                WT + R+ Q
Sbjct: 605 DPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT-VDRQPQ 663

Query: 740 NGDGFG--YLLSFRRQGSTHWQT--ARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRG 795
              G+   Y  +   Q ++ WQ   A+VP   +   V   + V     +E+K+R Y    
Sbjct: 664 FIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVT----YEIKVRPYFNEF 719

Query: 796 DGPESLTALVYSAEEEPRVAPTKVWAKGV---SSSEMNVTWEPVQQD-MNGILLGYEIRY 851
            G +S +  V + EE P   P  V    V   +S+ ++V+W+P   D  NGI+  Y+I  
Sbjct: 720 QGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-- 777

Query: 852 WKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPAS 900
           W  G++              S  + GL P  +Y V V A   AG G  S
Sbjct: 778 WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKS 826



 Score =  169 bits (429), Expect = 1e-41
 Identities = 200/776 (25%), Positives = 306/776 (39%), Gaps = 97/776 (12%)

Query: 32  QTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEM---KLEPGSRH 88
           Q  F P   + P  V+    S  E   L C+A   P  T  W  +G  +   K +P S  
Sbjct: 26  QEDFPPRIVEHPSDVIV---SKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHR 82

Query: 89  QLV-GGNL----VIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPV 143
            L+  G+L    ++       D G Y C+A N +G  VSR A L    L++  ++    V
Sbjct: 83  MLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDV 142

Query: 144 KAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG 203
               G   +L C PP  +P  +  W  ++       D    +S   G L I+ T  SD G
Sbjct: 143 VVAAGEPAILECQPPRGHPEPTIYWKKDKVRI---DDKEERISIRGGKLMISNTRKSDAG 199

Query: 204 NYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFA 263
            Y+C+ T+ +        S  A+L +    T L       R P     L  + V   C  
Sbjct: 200 MYTCVGTNMVGERD----SDPAELTVFERPTFL-------RRPINQVVLEEEAVEFRCQV 248

Query: 264 FGNPVPRIKWRKVDGSLSPQWTTAEP--TLQIPSVSFEDEGTYECEAENSKGRDTVQGRI 321
            G+P P ++W+K D  L       +   TL+I      DEGTY C AEN  G+      +
Sbjct: 249 QGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATL 308

Query: 322 IVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNG--------EPLASQNRV 373
            V+A P+++    D     G  + + C   G P+P V W + G        +P    +R 
Sbjct: 309 TVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRC 368

Query: 374 EVL-AGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPA-- 430
            V   GDL  + +   D+G Y C A    G+I A A+L V  +  D R  P+    PA  
Sbjct: 369 SVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTD-RPPPIILQGPANQ 427

Query: 431 --ARGGEILIPCQPRAAPKAVVLWSK-GTEILVNSSRVTVTPDGTLIIRNISRSDEGKYT 487
             A  G  L+ C+    P  V+ W K G        R T+   GTL I+N+  SD G YT
Sbjct: 428 TLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYT 487

Query: 488 CFAENFMGKANSTGILSVR----------DATKITLAPSSADIN--LGDNLTLQCHASHD 535
           C A +  G+ + + +L V           D + +   PS   +     +++TL       
Sbjct: 488 CVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTP 547

Query: 536 PTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMA-----Q 590
            T+  +  + ++ F              +VK T+  +      LR    Y  M      Q
Sbjct: 548 GTLPAS-AYIIEAFSQSVSN-SWQTVANHVKTTLYTV----RGLRPNTIYLFMVRAINPQ 601

Query: 591 TVVDSASKEATVLVRGPPGPPGGV----VVRDIGD-------------TTIQLSWSRGFD 633
            + D +     V  +    P  GV    V +++GD             TT+Q++W+    
Sbjct: 602 GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWT---V 658

Query: 634 NHSP--IAKYTLQARTPPAGKWKQVRTNPANIEGNAET---AQVLGLTPWMDYEFRVIAS 688
           +  P  I  Y +  R        Q  ++  N++    T   A ++ L   + YE +V   
Sbjct: 659 DRQPQFIQGYRVMYRQTSG---LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPY 715

Query: 689 NILGTGEPSGPSSKIRTREAAPSVAPSG---LSGGGGAPGELIVNWTPMSREYQNG 741
                G  S  S  +RT E APS  P     L+ G      + V+W P   ++QNG
Sbjct: 716 FNEFQGMDS-ESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNG 770



 Score =  147 bits (372), Expect = 4e-35
 Identities = 199/795 (25%), Positives = 304/795 (38%), Gaps = 128/795 (16%)

Query: 237 FAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSL--SPQWTTAEPTLQIP 294
           F P I    P++     G+  TL C A G P P I+W K DG    + +       + +P
Sbjct: 29  FPPRI-VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVETDKDDPRSHRMLLP 86

Query: 295 SVSF------------EDEGTYECEAENSKGRDTVQGRIIVQA--QPEWLKVISDTEADI 340
           S S              DEG+Y C A N  G    +   +  A  + ++ +  +D     
Sbjct: 87  SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 146

Query: 341 GSNLRWGCAAA-GKPRPTVRWLRNGEPLAS-QNRVEVLAGDLRFSKLSLEDSGMYQCVAE 398
           G      C    G P PT+ W ++   +   + R+ +  G L  S     D+GMY CV  
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT 206

Query: 399 NKHGTIYAS-AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTE 457
           N  G   +  AEL V    P F   P+ +++      E    CQ +  P+  V W K   
Sbjct: 207 NMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVEFR--CQVQGDPQPTVRWKKDDA 263

Query: 458 ILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSS 517
            L    R  +  D TL I+    +DEG Y C AEN +GK  ++  L+VR   +  + P  
Sbjct: 264 DLPRG-RYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRD 322

Query: 518 ADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNA 577
             +  G  +T  C    +P   + +        +  ++P     R +V  T GDLTI N 
Sbjct: 323 QIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT-GDLTITNI 381

Query: 578 QLRHGGKYTCMAQTVVDS----ASKEAT-VLVRGPP-----GPPGGVVVRD--------- 618
           Q    G Y C A TV  S    A  E T VL   PP     GP    +  D         
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 441

Query: 619 IGDTTIQLSWSR------GFDNHSPIAKY-TLQ---ARTPPAGKWKQVRTNPANIEGNAE 668
            GD    +SW +      G D  + I +  TLQ    R    G +  V T+ +   G   
Sbjct: 442 TGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSS---GETS 498

Query: 669 TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELI 728
            + VL +T     E     S      +  GP SK +  +   +     LS   G PG L 
Sbjct: 499 WSAVLDVT-----ESGATISKNYDLSDLPGPPSKPQVTDVTKNSVT--LSWQPGTPGTL- 550

Query: 729 VNWTPMSREYQNGDGFGYLL-SFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVK 787
               P S          Y++ +F +  S  WQT        +  +Y+   +RP T +   
Sbjct: 551 ----PAS---------AYIIEAFSQSVSNSWQTV---ANHVKTTLYTVRGLRPNTIYLFM 594

Query: 788 IRSYNRRG-DGPESLTALVYSAEEEPRVAPTKVWAKGV---------------------- 824
           +R+ N +G   P  ++  V + +  P        A+GV                      
Sbjct: 595 VRAINPQGLSDPSPMSDPVRTQDISPP-------AQGVDHRQVQKELGDVLVRLHNPVVL 647

Query: 825 SSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAAD------RVRTAGLDTSARVSGL 878
           + + + VTW   +Q     + GY + Y +    +A +       +V T   + SA +  L
Sbjct: 648 TPTTVQVTWTVDRQPQ--FIQGYRVMYRQTSGLQATSSWQNLDAKVPT---ERSAVLVNL 702

Query: 879 HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNIS----WTFSSSSLSIKWDP 934
                Y + VR Y     G  S S    T +  P  PP +++     +++S+S+S+ WDP
Sbjct: 703 KKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDP 762

Query: 935 VVPFRNESAVTGYKM 949
             P      +  YK+
Sbjct: 763 PPPDHQNGIIQEYKI 777


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
           2 precursor [Homo sapiens]
          Length = 1899

 Score =  202 bits (513), Expect = 2e-51
 Identities = 185/657 (28%), Positives = 281/657 (42%), Gaps = 62/657 (9%)

Query: 320 RIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGD 379
           R   +  P + +   D     G    + C A G PRP + W + G+ +++Q R EV+  D
Sbjct: 17  RTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQ-RFEVIEFD 75

Query: 380 ------LRFSKLSL-EDSGMYQCVAENKHGTIYASAELAVQALA------PDFRLNPVRR 426
                 LR   L    D  +Y+CVA N  G I  S  L V          P   + P  +
Sbjct: 76  DGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLK 135

Query: 427 LIPAARGGEILIPCQPRAAPKAVVLWSKG---TEILVNSSRVTVTPDGTLIIRNISRSDE 483
           ++   R   +L  C     P   + W K     +   N+ R+     G L I     SD+
Sbjct: 136 VVERTRTATML--CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQ 193

Query: 484 GKYTCFAENFMGKANSTG----ILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMD 539
           GKY C A N  G   S      +   R   + ++ P++ +I  G ++ + C A   P   
Sbjct: 194 GKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPY 253

Query: 540 LTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKE 599
           + +    +D   + D P G     NV E       LN  +R    YTC+A + +      
Sbjct: 254 VKWMLGAEDLTPEDDMPIGR----NVLE-------LN-DVRQSANYTCVAMSTLGVIEAI 301

Query: 600 ATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTN 659
           A + V+  P PPG  VV +   T+I L+W  G  N  P++ Y +Q +       K     
Sbjct: 302 AQITVKALPKPPGTPVVTESTATSITLTWDSG--NPEPVSYYIIQHKP------KNSEEL 353

Query: 660 PANIEGNAETA-QVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLS 718
              I+G A T   V GL+P+ DYEFRV+A N +G G PS P    +T E APS AP  + 
Sbjct: 354 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEP-VLTQTSEQAPSSAPRDVQ 412

Query: 719 GGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTH---WQTARVPGADAQYFVYSN 775
               +   ++V W     E  NG   GY + +    + H   W    V  AD+Q     N
Sbjct: 413 ARMLSSTTILVQW--KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNV--ADSQITTIGN 468

Query: 776 ESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEP 835
             + P   + VK+ ++   GDGP S    V +    P   P    A+  S + + ++W P
Sbjct: 469 --LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPG-QPLNFKAEPESETSILLSWTP 525

Query: 836 VQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAG 895
            + D    +  YE+ Y    D E   ++  T    TS R+ GL PN+ Y+  + A +  G
Sbjct: 526 PRSD---TIANYELVY---KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQG 579

Query: 896 TGPASPSANATTMKPPPRRPPGNISWTF-SSSSLSIKWDPVVPFRNESAVTGYKMLY 951
            G ++   +A TM+  P  PP +IS T  SS+S+ + W P    +    +T Y + Y
Sbjct: 580 LGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKY 636



 Score =  156 bits (395), Expect = 8e-38
 Identities = 179/753 (23%), Positives = 299/753 (39%), Gaps = 77/753 (10%)

Query: 258 TLECFAFGNPVPRIKWRK----VDGSLSPQWTTA--EPTLQIPSVSFEDEGTYECEAENS 311
           T+ C A GNP P I W K    VD S +           LQI      D+G YEC A NS
Sbjct: 144 TMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNS 203

Query: 312 KG-RDTVQGRIIVQAQ---PEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPL 367
            G R +    + V+ +   P +    ++ E   G ++   C A G P P V+W+   E L
Sbjct: 204 AGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL 263

Query: 368 ASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRL 427
             ++ + +    L  +   +  S  Y CVA +  G I A A++ V+AL            
Sbjct: 264 TPEDDMPIGRNVLELN--DVRQSANYTCVAMSTLGVIEAIAQITVKAL------------ 309

Query: 428 IPAARGGEILIPCQPRAAPKAVVLWSKGTEILV----------NSSRVTVTPDGTLIIR- 476
            P   G  ++       A    + W  G    V          NS  +    DG    R 
Sbjct: 310 -PKPPGTPVVTES---TATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 365

Query: 477 ---NISRSDEGKYTCFAENFMGKAN-STGILSVRDATKITLAPSSADINLGDNLTLQCHA 532
               +S   + ++   A N +G+   S  +L+       + AP      +  + T+    
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425

Query: 533 SHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKE----TIGDLTILNAQLRHGGKYTCM 588
                 +         + +D  +   ++ + NV +    TIG+L     Q  +  K    
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLV---PQKTYSVKVLAF 482

Query: 589 AQTVVDSASKEATVLVR-GPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQART 647
                   S +  V+ + G PG P         +T+I LSW+        IA Y L  + 
Sbjct: 483 TSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP--PRSDTIANYELVYKD 540

Query: 648 PPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTRE 707
              G+ +++   P        + ++ GL P   Y FR+ A +  G G  +   S  RT +
Sbjct: 541 GEHGEEQRITIEPGT------SYRLQGLKPNSLYYFRLAARSPQGLGASTAEISA-RTMQ 593

Query: 708 AAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGAD 767
           + PS  P  +S    +   ++V+W P   E QNG    Y + +        +   + G  
Sbjct: 594 SKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIP 653

Query: 768 AQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSS 827
           +    Y  E +  +T + + + ++   G GPESL+ L+ + E+ P   P KV  + V+S+
Sbjct: 654 SDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNST 713

Query: 828 EMNVTW-EPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSAR------------ 874
            + V+W  PV    +G + GY++ Y +  + E     +    +   A+            
Sbjct: 714 SVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI 773

Query: 875 VSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDP 934
           +SGL P T Y +TV AY   G G  S     +T    P +P   I+ T  +++L I+W P
Sbjct: 774 ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTAL-IQWHP 832

Query: 935 VVPFRNESAVTGYKMLY-QNDLHLTPTLHLTGK 966
             P      + GY++ + + D+    TL  + K
Sbjct: 833 --PVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK 863



 Score =  143 bits (361), Expect = 7e-34
 Identities = 164/757 (21%), Positives = 291/757 (38%), Gaps = 95/757 (12%)

Query: 244 RFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQW-------TTAEPTLQI-PS 295
           R P +   + G   +  C A G+P P+I W K    +S Q          +   L+I P 
Sbjct: 28  RTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPL 87

Query: 296 VSFEDEGTYECEAENSKGRDTVQGRIIVQAQPE------------WLKVISDTEADIGSN 343
            +  DE  YEC A N+ G  +V  R+ V  + +             LKV+  T       
Sbjct: 88  RTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR-----T 142

Query: 344 LRWGCAAAGKPRPTVRWLRNGEPLASQN---RVEVL-AGDLRFSKLSLEDSGMYQCVAEN 399
               CAA+G P P + W ++  P+ + N   R++ L +G L+  +    D G Y+CVA N
Sbjct: 143 ATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATN 202

Query: 400 KHGTIY---ASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGT 456
             GT Y   A+  + V+ + P F + P    I    GG + I C    +P   V W  G 
Sbjct: 203 SAGTRYSAPANLYVRVRRVPPRFSIPPTNHEI--MPGGSVNITCVAVGSPMPYVKWMLGA 260

Query: 457 EILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPS 516
           E L     +   P G  ++          YTC A + +G   +   ++V+   K    P 
Sbjct: 261 EDLTPEDDM---PIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPV 317

Query: 517 SADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHY----RRTNVKETIGDL 572
                           +      +T TW   +      +P  +Y    +  N +E   ++
Sbjct: 318 ---------------VTESTATSITLTWDSGN-----PEPVSYYIIQHKPKNSEELYKEI 357

Query: 573 --------TILNAQLRHGGKYTCMAQTVVDSASKEATVLV----RGPPGPPGGVVVRDIG 620
                   ++         ++  +A   +        VL     + P   P  V  R + 
Sbjct: 358 DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLS 417

Query: 621 DTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMD 680
            TTI + W    + +  I  Y +     P    + V     +   +++   +  L P   
Sbjct: 418 STTILVQWKEPEEPNGQIQGYRVYYTMDPT---QHVNNWMKHNVADSQITTIGNLVPQKT 474

Query: 681 YEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQN 740
           Y  +V+A   +G G P     ++ T+   P   P        +   ++++WTP     ++
Sbjct: 475 YSVKVLAFTSIGDG-PLSSDIQVITQTGVPG-QPLNFKAEPESETSILLSWTPP----RS 528

Query: 741 GDGFGYLLSFRRQGSTHWQTARV---PGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDG 797
                Y L ++     H +  R+   PG       Y  + ++P + +  ++ + + +G G
Sbjct: 529 DTIANYELVYK--DGEHGEEQRITIEPGTS-----YRLQGLKPNSLYYFRLAARSPQGLG 581

Query: 798 PESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ-QDMNGILLGYEIRYWKAGD 856
             +      + + +P   P  +     SS+ + V+W+P   +  NGI+  Y I+Y     
Sbjct: 582 ASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDG 641

Query: 857 KEAAADRVRTAGLDTSA-RVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRP 915
           ++     +     DT+   +  L   T+Y +TV A+   G GP S S    T +  P  P
Sbjct: 642 EDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP 701

Query: 916 PGNIS-WTFSSSSLSIKWDPVVPFRNESAVTGYKMLY 951
           P  +     +S+S+ + W   VP +    + GY++ Y
Sbjct: 702 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHY 738



 Score =  105 bits (261), Expect = 3e-22
 Identities = 210/956 (21%), Positives = 360/956 (37%), Gaps = 116/956 (12%)

Query: 61  CRARASPPATYRWKMNGTEMKLEPGSRHQLV-----GGNLVIMNPTKA-QDAGVYQCLAS 114
           C+A   P     W   G ++      R +++      G+++ + P +  +D  +Y+C+AS
Sbjct: 45  CQATGDPRPKIVWNKKGKKVS---NQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVAS 101

Query: 115 NPVG--TVVSREAILRFGFLQE-FSKEERDP-VKAHEGWGVMLPCNPPAHYPGLSYRWLL 170
           N VG  +V +R  +LR   +   F   +  P +K  E           +  P     W  
Sbjct: 102 NNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITW-- 159

Query: 171 NEFPNFIPTDGRH----FVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQ 226
             F +F+P D  +         +G L I ++  SD G Y C+AT+    S  + +S  A 
Sbjct: 160 --FKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATN----SAGTRYSAPAN 213

Query: 227 LNLAAEDTRLFAPSIKARF---PAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQ 283
           L +           +  RF   P     + G  V + C A G+P+P +KW      L+P+
Sbjct: 214 LYVRVR-------RVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 266

Query: 284 --WTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQA--QPEWLKVISDTEAD 339
                    L++  V       Y C A ++ G      +I V+A  +P    V++++ A 
Sbjct: 267 DDMPIGRNVLELNDV--RQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTA- 323

Query: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAG--DLRFSKLSLEDSGMYQ--C 395
               L W    +G P P   ++   +P  S+   + + G    R+S   L     Y+   
Sbjct: 324 TSITLTWD---SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV 380

Query: 396 VAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKG 455
           VA N  G    S  +  Q               P++   +  +  +  ++   +V W + 
Sbjct: 381 VAVNNIGRGPPSEPVLTQ----------TSEQAPSSAPRD--VQARMLSSTTILVQWKEP 428

Query: 456 TEI--LVNSSRVTVTPDGTLIIRNISRSD--EGKYTCFAENFMGKANSTGILSVRDATKI 511
            E    +   RV  T D T  + N  + +  + + T        K  S  +L+    T I
Sbjct: 429 EEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAF---TSI 485

Query: 512 TLAPSSADINL-------GDNLTLQCHASHDPTMDLTFTWTLDDFPIDFD---KPGGHYR 561
              P S+DI +       G  L  +     + ++ L++T    D   +++   K G H  
Sbjct: 486 GDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGE 545

Query: 562 RTNVKETIGDLTILNAQLRHGGKYTCMAQTV-----VDSASKEATVLVRGPPGPPGGVVV 616
              +    G    L     +   Y  +A          +A   A  +   P  PP  +  
Sbjct: 546 EQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISC 605

Query: 617 RDIGDTTIQLSWSRG--FDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEG-NAETAQVL 673
                T+I +SW        +  I +Y+++         K     P  I G  ++T + L
Sbjct: 606 TSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDK-----PHEILGIPSDTTKYL 660

Query: 674 --GLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNW 731
              L  W +Y   V A   +G G P   S  IRT E  PS  P  +         + V+W
Sbjct: 661 LEQLEKWTEYRITVTAHTDVGPG-PESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSW 719

Query: 732 TPMSREYQNGDGFGYLLSFRR--QGSTHWQ--TARVPGADAQY-FVYSNE------SVRP 780
                  Q+G   GY + + R   G    Q     V  ADAQ+ F  + E       ++P
Sbjct: 720 RSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQP 779

Query: 781 YTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMN---VTWEPVQ 837
            T + + + +Y  +GDG  S   LV +    P   P  V    ++ ++MN   + W P  
Sbjct: 780 ETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG-KPRLV----INHTQMNTALIQWHP-P 833

Query: 838 QDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTG 897
            D  G L GY +++ +  D E     +  +  +     + +H    Y   + A N+ G G
Sbjct: 834 VDTFGPLQGYRLKFGRK-DMEPLT-TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 891

Query: 898 PASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQN 953
                  +   + P   P    S   +S+S+ + W P V       +T Y +LY++
Sbjct: 892 EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRD 947



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 121/522 (23%), Positives = 202/522 (38%), Gaps = 58/522 (11%)

Query: 464  RVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLG 523
            R+T+ P  +  ++ +  +    +   A +  G   ST  +S R       AP   DI+  
Sbjct: 548  RITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQ-DISCT 606

Query: 524  DNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIG---DLT-ILNAQL 579
               +     S  P         + ++ I +    G   + +  E +G   D T  L  QL
Sbjct: 607  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH--EILGIPSDTTKYLLEQL 664

Query: 580  RHGGKY--TCMAQTVVDSASKEATVLVRG----PPGPPGGVVVRDIGDTTIQLSWSRGFD 633
                +Y  T  A T V    +  +VL+R     P GPP  V V  +  T++++SW     
Sbjct: 665  EKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 724

Query: 634  N--HSPIAKYTLQ----ARTPPAGK--WKQVRTNPANIEGNAETAQ---VLGLTPWMDYE 682
            N  H  I  Y +         P G+   K V    A  E +  T     + GL P   Y 
Sbjct: 725  NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 784

Query: 683  FRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGE--LIVNWTPMSRE--- 737
              V A    G G  S P                 +S  G  PG+  L++N T M+     
Sbjct: 785  LTVTAYTTKGDGARSKPKL---------------VSTTGAVPGKPRLVINHTQMNTALIQ 829

Query: 738  -YQNGDGFG----YLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYN 792
             +   D FG    Y L F R+      T      +  +   +   +     +  ++ + N
Sbjct: 830  WHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHF---TATDIHKGASYVFRLSARN 886

Query: 793  RRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEP-VQQDMNGILLGYEIRY 851
            + G G E +   +   EE P   P  + ++G +S+ + ++W+P V  + NGI+  Y + Y
Sbjct: 887  KVGFG-EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY 945

Query: 852  WKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPP 911
                      +++     DT+  ++GL P+T Y V VRA+   G GP SPS    T+   
Sbjct: 946  RDINIPLLPMEQLIVPA-DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD 1004

Query: 912  PRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQN 953
                          +S+ + W+  +P  N ++   +K+LY +
Sbjct: 1005 QVFAKNFHVKAVMKTSVLLSWE--IP-ENYNSAMPFKILYDD 1043


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  198 bits (504), Expect = 2e-50
 Identities = 256/1012 (25%), Positives = 414/1012 (40%), Gaps = 114/1012 (11%)

Query: 16  AVALVSSSAWSSALGSQTTFGPV-FEDQPLSVLFPEESTEEQVLLACRARASPPATYRWK 74
           A A  S SA  S   S  TF P  F  +P+  L    S+   V+L C A + P     WK
Sbjct: 31  AAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSS---VILNCSAYSEPSPKIEWK 87

Query: 75  MNGTEMKLEPGSRHQLV-GGNLVIMNPTKAQ----DAGVYQCLAS-NPVGTVVSREAILR 128
            +GT + L    R QL+  G+L I N   ++    D G YQC+A+   +GT++SR A L 
Sbjct: 88  KDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLI 147

Query: 129 FGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQT 188
              L  F+ +  +P   + G   +L C   A       RW  N  P  +  D R  +   
Sbjct: 148 VAGLPRFTSQP-EPSSVYAGNNAILNCEVNADLVPF-VRWEQNRQPLLL--DDR-VIKLP 202

Query: 189 TGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAE 248
           +G L I+     D G Y C+  S         +S   +L +   D  + +  +  + P+ 
Sbjct: 203 SGMLVISNATEGDGGLYRCVVES----GGPPKYSDEVELKVLP-DPEVISDLVFLKQPSP 257

Query: 249 TYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTT-----AEPTLQIPSVSFEDEGT 303
              ++GQ V L C A G P P IKW K + +L  + +      A  +L+I  V+ +D GT
Sbjct: 258 LVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGT 317

Query: 304 YECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRN 363
           Y C A+N       Q  + VQAQPE+LK  ++  A    ++ + C   GKP PTV+W++N
Sbjct: 318 YFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377

Query: 364 GEPLASQNRVEVL-AGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFR-- 420
           G+ +   +  +++   +L+   L   D G YQC+AEN  G   A A+L +   AP     
Sbjct: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437

Query: 421 LNPVRRLIPAARGGEILIPC---QPRAAPKA-----VVLWSKGTEILVNSSRVTVTPDGT 472
           L    R + A+      I      P + P        V ++K           +   +  
Sbjct: 438 LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497

Query: 473 LIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHA 532
           + I+N+  +    +   A+N  G   S+  L V    ++ L         G    L+ +A
Sbjct: 498 VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLP--------GPAPNLRAYA 549

Query: 533 SHDPTMDLTFTWTLDDFPIDFDKPGGHYR-----RTNVKETIGDLTILNAQLRHGGKYTC 587
           +  PT  +T TW   + P+  +    +Y+     +   KE   D++  +  +    KYT 
Sbjct: 550 A-SPT-SITVTW---ETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTE 604

Query: 588 MAQTV---------VDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWS--RGFDNHS 636
            +  V         V +       L   P   P  + +      +I + W        + 
Sbjct: 605 YSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNG 664

Query: 637 PIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEP 696
            I  Y ++ R       ++       + G   +  + GL    +Y FRV A  I GTG  
Sbjct: 665 QITGYKIRYRKAS----RKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPA 720

Query: 697 ----SGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRR 752
               S  + +    E      PS L         ++V+WTP   E QN    GY + +  
Sbjct: 721 TDWLSAETFESDLDETRVPEVPSSLH-VRPLVTSIVVSWTP--PENQNIVVRGYAIGY-G 776

Query: 753 QGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDG----------PESLT 802
            GS H QT +V   D +   Y+ E++ P + + + ++++N  G+G          P + T
Sbjct: 777 IGSPHAQTIKV---DYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDT 833

Query: 803 ALV--------YS--AEEEPRVAPTKVWAKGVSSSEMNVTWE----PVQQDMNGILLGYE 848
           + V        Y+   +  P + P  V A  +S   + +TW     P  Q +      Y 
Sbjct: 834 SEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRY-YT 892

Query: 849 IRYWKAGDKEAAADRVRTAGLDT-SARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATT 907
           +R WK      A  + + A   T S  V+GL PNT Y  +V       +   S +A+ TT
Sbjct: 893 VR-WKT--NIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTT 949

Query: 908 MKPPPRRPPGN---ISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLH 956
            +  P  PP +   +S      ++ + W P  P      +TGY + Y  D++
Sbjct: 950 FELVPTSPPKDVTVVSKEGKPKTIIVNWQP--PSEANGKITGYIIYYSTDVN 999



 Score =  196 bits (497), Expect = 1e-49
 Identities = 211/838 (25%), Positives = 352/838 (42%), Gaps = 85/838 (10%)

Query: 235  RLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSL------SPQWTTAE 288
            R F P      P +T ++ G  V L C A+  P P+I+W+K DG+         +    +
Sbjct: 48   RTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKK-DGTFLNLVSDDRRQLLPD 106

Query: 289  PTLQIPSVSFE-----DEGTYECEAENSKGRDTVQ--GRIIVQAQPEWLKVISDTEADIG 341
             +L I +V        DEG Y+C A        +    ++IV   P +      +    G
Sbjct: 107  GSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAG 166

Query: 342  SNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVL-AGDLRFSKLSLEDSGMYQCVAENK 400
            +N    C       P VRW +N +PL   +RV  L +G L  S  +  D G+Y+CV E+ 
Sbjct: 167  NNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG 226

Query: 401  HGTIYASAELAVQALAPDFRL----------NPVRRLIPAARGGEILIPCQPRAAPKAVV 450
                Y S E+ ++ L PD  +          +P+ R+I    G ++++PC     P   +
Sbjct: 227  GPPKY-SDEVELKVL-PDPEVISDLVFLKQPSPLVRVI----GQDVVLPCVASGLPTPTI 280

Query: 451  LWSKGTEIL--VNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDA 508
             W K  E L   +S R+ +   G+L I +++  D G Y C A+N      +   L+V+  
Sbjct: 281  KWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQ 340

Query: 509  TKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKET 568
             +    P++   +   ++  +C  +  PT   T  W  +    D   P  +++   VKE 
Sbjct: 341  PEFLKQPTNIYAHESMDIVFECEVTGKPTP--TVKWVKNG---DMVIPSDYFKI--VKEH 393

Query: 569  IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV-------RGP-PGPPGGVVVRDIG 620
              +L +L       G Y C+A+  V +A   A +++        GP P  P  VV   + 
Sbjct: 394  --NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVS 451

Query: 621  DTTIQLSW-SRGFDNHSPIAKYTL-QARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPW 678
               I+L+W +   D H     Y++   +   A +  +  ++P  ++       +  L P 
Sbjct: 452  TRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ-----VTIQNLMPA 506

Query: 679  MDYEFRVIASNILGTGEPSGPSSKIRTREAA--PSVAPSGLSGGGGAPGELIVNW-TPMS 735
              Y FRV+A N  G+GE S P  ++ T+     P  AP+ L     +P  + V W TP+S
Sbjct: 507  TVYIFRVMAQNKHGSGESSAPL-RVETQPEVQLPGPAPN-LRAYAASPTSITVTWETPVS 564

Query: 736  REYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRG 795
                NG+   Y L +  +G     T +    D     Y+   ++ YT +  ++ +YN+ G
Sbjct: 565  G---NGEIQNYKLYYMEKG-----TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHG 616

Query: 796  DGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEP-VQQDMNGILLGYEIRYWKA 854
             G  +    V +  + P  AP  +  +  +S  + + W+P      NG + GY+IRY KA
Sbjct: 617  PGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKA 676

Query: 855  GDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMK---PP 911
              K    + +  +G   S  + GL   T+Y+  V A    GTGPA+   +A T +     
Sbjct: 677  SRKSDVTETL-VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDE 735

Query: 912  PRRP--PGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGK-NW 968
             R P  P ++      +S+ + W P  P      V GY + Y        T+ +  K  +
Sbjct: 736  TRVPEVPSSLHVRPLVTSIVVSWTP--PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRY 793

Query: 969  IEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGT-----SMMVENMAVRPAPHP 1021
              I   +   H ++ ++     G+GIP     V    T      + V N    P P P
Sbjct: 794  YTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDP 851



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 200/928 (21%), Positives = 352/928 (37%), Gaps = 120/928 (12%)

Query: 58   LLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPV 117
            +L C   A      RW+ N   + L+     +L  G LVI N T+  D G+Y+C+  +  
Sbjct: 170  ILNCEVNADLVPFVRWEQNRQPLLLDDRVI-KLPSGMLVISNATEG-DGGLYRCVVESGG 227

Query: 118  GTVVSREAILRFGFLQEFSKE-----ERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNE 172
                S E  L+     E   +     +  P+    G  V+LPC   +  P  + +W+ NE
Sbjct: 228  PPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPC-VASGLPTPTIKWMKNE 286

Query: 173  FPNFIPTDG-RHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAA 231
                + T+     V    G+L I+     D G Y C+A    D   +++ ++ A+L + A
Sbjct: 287  --EALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIA----DNGNETIEAQ-AELTVQA 339

Query: 232  EDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQ---WTTAE 288
            +   L       + P   YA     +  EC   G P P +KW K    + P        E
Sbjct: 340  QPEFL-------KQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKE 392

Query: 289  PTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIV-QAQPEWLKVISDTEADIGSNL--- 344
              LQ+  +   DEG Y+C AEN  G      ++I+ +  P     +     D+ ++L   
Sbjct: 393  HNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVST 452

Query: 345  -----RWGCAAAGKPRPTVRW--LRNGEPLASQNRVEVLA--GDLRFSKLSLEDSGMY-- 393
                  W   A+      + +      E +A + RVE  +  G+++ +  +L  + +Y  
Sbjct: 453  RFIKLTWRTPASDPHGDNLTYSVFYTKEGIARE-RVENTSHPGEMQVTIQNLMPATVYIF 511

Query: 394  QCVAENKHGTIYASAELAVQALAPDFRL-NPVRRLIP-AARGGEILIPCQPRAAPKAVV- 450
            + +A+NKHG+  +SA L V+   P+ +L  P   L   AA    I +  +   +    + 
Sbjct: 512  RVMAQNKHGSGESSAPLRVET-QPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQ 570

Query: 451  -----LWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSV 505
                    KGT+       V V+   +  I  + +  E  +   A N  G   ST  ++V
Sbjct: 571  NYKLYYMEKGTD---KEQDVDVSSH-SYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAV 626

Query: 506  RDATKI-TLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTN 564
            R  + + + AP +  + + ++ ++  H    P    T    +  + I + K     R+++
Sbjct: 627  RTLSDVPSAAPQNLSLEVRNSKSIMIH--WQPPAPATQNGQITGYKIRYRKAS---RKSD 681

Query: 565  VKETI---GDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGP-----------PGP 610
            V ET+     L+ L   L  G +Y      +  + +  AT  +              P  
Sbjct: 682  VTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEV 741

Query: 611  PGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQ--ARTPPAGKWKQVRTNPANIEGNAE 668
            P  + VR +  T+I +SW+   + +  +  Y +     +P A   K        ++    
Sbjct: 742  PSSLHVRPLV-TSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIK--------VDYKQR 792

Query: 669  TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTR-------------------EAA 709
               +  L P   Y   + A N +G G P   S+  R                     +  
Sbjct: 793  YYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPT 852

Query: 710  PSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQT-----ARVP 764
            P + P G+     +   + + W   S            ++  R  +  W+T      +  
Sbjct: 853  PMMPPVGVQASILSHDTIRITWADNSLPKHQK------ITDSRYYTVRWKTNIPANTKYK 906

Query: 765  GADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVW--AK 822
             A+A    Y    ++P T +E  +     R     S+TA   + E  P   P  V   +K
Sbjct: 907  NANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSK 966

Query: 823  GVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVR-TAGLDTSARVSGLHPN 881
                  + V W+P   + NG + GY I Y    + E     +    G   + ++  L  +
Sbjct: 967  EGKPKTIIVNWQP-PSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLD 1025

Query: 882  TKYHVTVRAYNRAGTGPASPSANATTMK 909
            T Y+  ++A N  G GP S +    T K
Sbjct: 1026 TPYYFKIQARNSKGMGPMSEAVQFRTPK 1053


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,106,135
Number of Sequences: 37866
Number of extensions: 2287019
Number of successful extensions: 19518
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 222
Number of HSP's that attempted gapping in prelim test: 8301
Number of HSP's gapped (non-prelim): 4447
length of query: 1040
length of database: 18,247,518
effective HSP length: 112
effective length of query: 928
effective length of database: 14,006,526
effective search space: 12998056128
effective search space used: 12998056128
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.