Search of human proteins with 4826834

Search of human proteins with 4826834

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4826834 matrix metalloproteinase 14 preproprotein [Homo
sapiens]
         (582 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]  1222   0.0  
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   689   0.0  
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   674   0.0  
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   649   0.0  
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   466   e-131
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   370   e-102
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   361   1e-99
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   300   2e-81
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   294   1e-79
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    294   2e-79
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    291   9e-79
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   290   2e-78
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   289   4e-78
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   281   2e-75
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   272   5e-73
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      268   8e-72
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                260   3e-69
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   256   3e-68
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   233   3e-61
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      199   8e-51
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   199   8e-51
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    182   1e-45
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   147   2e-35
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   135   8e-32
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   131   2e-30
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       84   3e-16
gi|88853069 vitronectin precursor [Homo sapiens]                       80   7e-15
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    77   4e-14
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]           67   3e-11
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           67   5e-11

>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score = 1222 bits (3162), Expect = 0.0
 Identities = 582/582 (100%), Positives = 582/582 (100%)

Query: 1   MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS 60
           MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
Sbjct: 1   MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS 60

Query: 61  LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ 120
           LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
Sbjct: 61  LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ 120

Query: 121 HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF 180
           HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
Sbjct: 121 HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF 180

Query: 181 FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE 240
           FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
Sbjct: 181 FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE 240

Query: 241 LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT 300
           LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
Sbjct: 241 LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT 300

Query: 301 SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF 360
           SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
Sbjct: 301 SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF 360

Query: 361 WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF 420
           WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
Sbjct: 361 WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF 420

Query: 421 WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG 480
           WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
Sbjct: 421 WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG 480

Query: 481 NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA 540
           NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
Sbjct: 481 NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA 540

Query: 541 AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582
           AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
Sbjct: 541 AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  689 bits (1779), Expect = 0.0
 Identities = 343/642 (53%), Positives = 433/642 (67%), Gaps = 72/642 (11%)

Query: 12  LLPLLTLGTALASLG-SAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQK 70
           LLPLL +      LG +A+ +    E WL+ YGYLP       T RS Q L++A+A MQ+
Sbjct: 29  LLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQR 88

Query: 71  FYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANV--RRKRYAIQGLKWQHNEITFCI 128
           FYG+ VTG  D +T + M+RPRCGVPD+FG  +KAN+  RRKRYA+ G KW ++ +TF I
Sbjct: 89  FYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSI 148

Query: 129 QNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGD 188
           QNYT K+G Y + EA+R+AFRVWE ATPL F+EVPY  IR   +K+ADIM+ FA GFHGD
Sbjct: 149 QNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGD 208

Query: 189 STPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLE 248
           S+PFDG GGFLAHAYFPGP +GGDTHFD+ EPWT  + DL+GN++FLVAVHELGHALGLE
Sbjct: 209 SSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLE 268

Query: 249 HSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT-SRPSVPD 307
           HSS+P+AIMAPFYQW D +NF LP+DD RGIQQLYG   G P    P P  T  RP  PD
Sbjct: 269 HSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPD 328

Query: 308 --------------KPKNP----------------TYGPNICDGNFDTVAMLRGEMFVFK 337
                         KP+ P                 YGPNICDG+FDTVAMLRGEMFVFK
Sbjct: 329 HRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFK 388

Query: 338 ERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEP 397
            RWFWRVR+N+V+D YPMPIG FWRGLP  I+ AYER+DG+FVFFKGD++W+F EA+LEP
Sbjct: 389 GRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEP 448

Query: 398 GYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWE 457
           GYP+ +   G G+P D+ID A++W P G T+FF+ ++Y+RFNEE +  D  YPK I VW+
Sbjct: 449 GYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQ 508

Query: 458 GIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC--------- 508
           GIP SP+G+F+ +D  +TYFYKG KYWKF+N++L++EPGYPKS LRD+MGC         
Sbjct: 509 GIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPR 568

Query: 509 ----------PSGGRPDEGTEEETEV------------------IIIEVDEEGGGAVSAA 540
                     P GG        E +V                  +++++ EE    V+  
Sbjct: 569 WPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQM-EEVARTVNVV 627

Query: 541 AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582
            V++P+LLLL VL +  A+   +R G PR LLYC+RSL + V
Sbjct: 628 MVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV 669


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  674 bits (1740), Expect = 0.0
 Identities = 323/586 (55%), Positives = 418/586 (71%), Gaps = 19/586 (3%)

Query: 15  LLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGL 74
           L TL   L +        F+ E WLQ+YGYLPP D R    RS +++ +A+AAMQ+FYG+
Sbjct: 23  LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82

Query: 75  QVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPK 134
            +TGK D +T+  M++PRCGVPD+     K ++RRKRYA+ G KWQH  IT+ I+N TPK
Sbjct: 83  NMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPK 142

Query: 135 VGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDG 194
           VG+  T +AIR+AF VW++ TPL F EVPY+ +  G ++  DI I FA GFHGDS+PFDG
Sbjct: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENG-KRDVDITIIFASGFHGDSSPFDG 201

Query: 195 EGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPS 254
           EGGFLAHAYFPGP IGGDTHFDS EPWT+ N + +GND+FLVAVHELGHALGLEHS+DP+
Sbjct: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPT 261

Query: 255 AIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVP-------D 307
           AIMAPFYQ+M+T+NF LP+DD +GIQ++YG     P    P P      S+P       D
Sbjct: 262 AIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKND 321

Query: 308 KPK-------NPTYG---PNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPI 357
           +PK        P+Y    PNICDGNF+T+A+LR EMFVFK++WFWRVRNN+VMDGYPM I
Sbjct: 322 RPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQI 381

Query: 358 GQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDA 417
             FWRGLP SI+  YE  DG FVFFKG+K+WVF + +L+PGYP  +  LG G+P   ID+
Sbjct: 382 TYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDS 441

Query: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYF 477
           A++W   GKTYFF+G++Y+R++EE++ +D  YPK I VW+GIPESP+G+F+  +  FTYF
Sbjct: 442 AIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYF 501

Query: 478 YKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS-GGRPDEGTEEETEVIIIEVDEEGGGA 536
           YKG +YWKFNNQ LKVEPGYP+S L+D+MGC     R  EG     +V I+   +     
Sbjct: 502 YKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTAST 561

Query: 537 VSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582
           V A A+V+P +L L +L +   VF F+R GTPR +LYC+RS+ + V
Sbjct: 562 VKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 607


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  649 bits (1674), Expect = 0.0
 Identities = 321/586 (54%), Positives = 408/586 (69%), Gaps = 26/586 (4%)

Query: 18  LGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVT 77
           +  A+A    A++  F+ + WL+ YGYL P D R     S ++L +A++ MQ+FYG+ VT
Sbjct: 65  VAVAVARADEAEAP-FAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVT 123

Query: 78  GKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGE 137
           G  D  T++ M++PRCGVPD     +    R KRYA+ G KW+   IT+ I NYTPKVGE
Sbjct: 124 GVLDQTTIEWMKKPRCGVPDH--PHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGE 181

Query: 138 YATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGG 197
             T +AIR+AF VW+  TPL F EVPY  I+    K+ADIMIFFA GFHGDS+PFDGEGG
Sbjct: 182 LDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDR-KEADIMIFFASGFHGDSSPFDGEGG 240

Query: 198 FLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIM 257
           FLAHAYFPGP IGGDTHFDS EPWT+ N + +GND+FLVAVHELGHALGLEHSSDPSAIM
Sbjct: 241 FLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIM 300

Query: 258 APFYQWMDTENFVLPDDDRRGIQQLYG--GESGFPTKMPP-----------------QPR 298
           APFYQ+M+T NF LP DD +GIQ++YG   E   PT+  P                 QPR
Sbjct: 301 APFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPR 360

Query: 299 TTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIG 358
              RP + D+P  P   PNICDGNF+TVA+ RGEMFVFK+RWFWR+RNN+V +GYPM I 
Sbjct: 361 PP-RPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIE 419

Query: 359 QFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAA 418
           QFW+GLPA I+ AYER DG+FVFFKGDK+WVF E ++EPGYP  + ELG  LP + ID A
Sbjct: 420 QFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTA 479

Query: 419 LFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFY 478
           L W P GKTYFF+G +Y+R++EE RA D  YPK I VW+GIP++P+G+F+  +  +TYFY
Sbjct: 480 LRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFY 539

Query: 479 KGNKYWKFNNQKLKVEPGYPKSALRDWMGC--PSGGRPDEGTEEETEVIIIEVDEEGGGA 536
           KG  YWKF+NQKL VEPGYP++ LRDWMGC      R  E    + +V I+    +  G+
Sbjct: 540 KGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGS 599

Query: 537 VSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582
           V+A AVV+P +L L +L +   +F F+    P+ + Y +R + + V
Sbjct: 600 VNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 645


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  466 bits (1198), Expect = e-131
 Identities = 230/416 (55%), Positives = 287/416 (68%), Gaps = 20/416 (4%)

Query: 15  LLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGL 74
           L TL   L +        F+ E WLQ+YGYLPP D R    RS +++ +A+AAMQ+FYG+
Sbjct: 23  LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82

Query: 75  QVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPK 134
            +TGK D +T+  M++PRCGVPD+     K ++RRKRYA+ G KWQH  IT+ I+N TPK
Sbjct: 83  NMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPK 142

Query: 135 VGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDG 194
           VG+  T +AIR+AF VW++ TPL F EVPY+ +  G ++  DI I FA GFHGDS+PFDG
Sbjct: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENG-KRDVDITIIFASGFHGDSSPFDG 201

Query: 195 EGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPS 254
           EGGFLAHAYFPGP IGGDTHFDS EPWT+ N + +GND+FLVAVHELGHALGLEHS+DP+
Sbjct: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPT 261

Query: 255 AIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKM-------------PPQPRTTS 301
           AIMAPFYQ+M+T+NF LP+DD +GIQ++YG     P                P  PR   
Sbjct: 262 AIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKND 321

Query: 302 RPSVP----DKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPI 357
           RP  P     +P  P   PNICDGNF+T+A+LR EMFVFK++WFWRVRNN+VMDGYPM I
Sbjct: 322 RPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQI 381

Query: 358 GQFWRGLPASINTAYERKDGKFVFF--KGDKHWVFDEASLEPGYPKHIKELGRGLP 411
             FWRGLP SI+  YE  DG FVFF  KGD   +  +  L   + K I E  + +P
Sbjct: 382 TYFWRGLPPSIDAVYENSDGNFVFFKVKGDTLSIIQDGWLYKYHWKWILEQRQSVP 437


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  370 bits (951), Expect = e-102
 Identities = 226/569 (39%), Positives = 310/569 (54%), Gaps = 45/569 (7%)

Query: 12  LLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKF 71
           LL LL    A A   SAQ  S   + WL +YGYLPP        +SP+ L  AI  MQ+F
Sbjct: 10  LLLLLLAPPARAPKPSAQDVSLGVD-WLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRF 68

Query: 72  YGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNY 131
            GL  TG+ D  T+  MR+PRC +PD  G       RR+RYA+ G  W+   +T+ ++++
Sbjct: 69  AGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVR-RRRRYALSGSVWKKRTLTWRVRSF 127

Query: 132 --TPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDS 189
             + ++ +      +  A   W   + L F EV      +G E   DI+I FA  FH DS
Sbjct: 128 PQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSP---QGQEP--DILIDFARAFHQDS 182

Query: 190 TPFDGEGGFLAHAYFPGPN-IGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLE 248
            PFDG GG LAHA+FPG + I GDTHFD  E WT  ++D  G D+F VAVHE GHALGL 
Sbjct: 183 YPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLG 242

Query: 249 HSSDPSAIMAPFYQWM--DTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSV- 305
           HSS P++IM PFYQ    D + + L  DDR G+QQLYG          P  + T +P   
Sbjct: 243 HSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYG-----KAPQTPYDKPTRKPLAP 297

Query: 306 -PDKPKNPTYGPNI-----CDGNFDTVAMLRGEMFVFKERWFWRVR-NNQVMDGYPMPIG 358
            P  P +PT+ P+      C+GNFD +A +RGE F FK  WFWR++ + Q++   P  + 
Sbjct: 298 PPQPPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLH 357

Query: 359 QFWRGLPAS---INTAYER-KDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDK 414
           +FW GLPA    +  AY R +DG+ + F G + WVF +  LE G  + + ELG   P ++
Sbjct: 358 RFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLP-PGEE 415

Query: 415 IDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVF 474
           +DA   W  NGKTY  RG +Y+R++E     D  YP+++ +WEG P SP      S+   
Sbjct: 416 VDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSP-DDVTVSNAGD 474

Query: 475 TYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS------GGRPDEGTE-EETEVIII 527
           TYF+KG  YW+F    +K EP  P+    +W+ CP+        RP + T   ET     
Sbjct: 475 TYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQC 534

Query: 528 EVDEEGGGAVSAAAVVLPVLLLLLVLAVG 556
           E+++  G   +      P+ LLLL L VG
Sbjct: 535 ELNQAAGRWPA------PIPLLLLPLLVG 557


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  361 bits (926), Expect = 1e-99
 Identities = 208/535 (38%), Positives = 295/535 (55%), Gaps = 49/535 (9%)

Query: 3   PAPRPP----RCLLLPLLTLGTALASLGSAQSSSFSPEA--------WLQQYGYLPPGDL 50
           P P PP      L LPLL L  AL + G   + + +P A        WL ++GYLPP D 
Sbjct: 9   PGPPPPGPGLSRLPLPLLLL-LALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADP 67

Query: 51  RTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRK 110
            T   ++ + LS AI AMQ+F GL+ TG  D  T+  M+ PRC +PD     +    RR+
Sbjct: 68  TTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD---LPVLTQARRR 124

Query: 111 RYAIQGLKWQHNEITFCIQNYT--PKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIR 168
           R A    KW    +++ ++ +     +G       +  A +VW    PL F EV  +   
Sbjct: 125 RQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGS--- 181

Query: 169 EGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPN-IGGDTHFDSAEPWTVRNED 227
                 ADI I F++  H D  PFDG GG +AHA+FPG +   GDTHFD  E WT R+ D
Sbjct: 182 -----AADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSD 236

Query: 228 LNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWM--DTENFVLPDDDRRGIQQLYG- 284
            +G D+F VAVHE GHA+GL H +   +IM P+YQ    D   + LP +D+  + QLYG 
Sbjct: 237 AHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGV 296

Query: 285 GESGFPTKMPPQPRTTSRPSVPDKPKNPTYG------PNICDGNFDTVAMLRGEMFVFKE 338
            ES  PT  P +P     P +P+ P N +        P+ C  +FD VA +RGE F FK 
Sbjct: 297 RESVSPTAQPEEP-----PLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKG 351

Query: 339 RWFWRV-RNNQVMDGYPMPIGQFWRGLPA---SINTAYER-KDGKFVFFKGDKHWVFDEA 393
           ++FWR+ R+  ++   P  + +FWRGLP    S++  YER  D K VFFKGD++WVF + 
Sbjct: 352 KYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDN 411

Query: 394 SLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI 453
           ++E GYP+ + +    LP   IDAA  W  N +TYFF+   Y+R+++  R +D  YP   
Sbjct: 412 NVEEGYPRPVSDF--SLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQS 469

Query: 454 KVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
            +W G+P +   +   SD   +YF++G +YWK  + +L+V PGYP+S  RDW+ C
Sbjct: 470 PLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVC 523


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  300 bits (769), Expect = 2e-81
 Identities = 173/469 (36%), Positives = 249/469 (53%), Gaps = 27/469 (5%)

Query: 45  LPPGDLRTHTQR-SPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEI 103
           LPP     H +R  PQ   AA+ +         T +A      ++R PRCGVPD     +
Sbjct: 34  LPPDAHHLHAERRGPQPWHAALPSSPA--PAPATQEAPRPA-SSLRPPRCGVPDPSDG-L 89

Query: 104 KANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVP 163
            A  R+KR+ + G +W+  ++T+ I  +  ++ +    + + +A +VW   TPL F EV 
Sbjct: 90  SARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEV- 148

Query: 164 YAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV 223
                  HE +ADIMI FA  +HGD  PFDG GG LAHA+FP  +  GD HFD  E WT+
Sbjct: 149 -------HEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTI 201

Query: 224 RNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLY 283
            ++   G D+  VA HE GH LGL+H++   A+M+ FY +    +  L  DD RG+Q LY
Sbjct: 202 GDDQ--GTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS--LSPDDCRGVQHLY 257

Query: 284 GGESGFPTKMPPQPRTTSRPSVPDK---PKNPTYGPNICDGNFDTVAMLRGEMFVFKERW 340
           G    +PT     P    +  +      P  P   P+ C+ +FD V+ +RGE+F FK  +
Sbjct: 258 G--QPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGF 315

Query: 341 FWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYP 400
            WR+R  Q+  GYP    + W+GLP+ ++ A+E   G   FF+G ++WV+D      G P
Sbjct: 316 VWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLG-P 374

Query: 401 KHIKELGRGLPTDKIDAALFWMP-NGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGI 459
             + EL  GL    + AAL W P   K YFFRG  Y+RF+   R VDS  P+    W G+
Sbjct: 375 APLTEL--GLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGV 432

Query: 460 PESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
           P     +F  +D  + YF +G  YWKF+  K+K   G+P+    D+ GC
Sbjct: 433 PSEIDAAFQDADG-YAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480



 Score = 33.5 bits (75), Expect = 0.55
 Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 2/35 (5%)

Query: 476 YFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPS 510
           +F+K    W+    +L  +PGYP  A R W G PS
Sbjct: 309 FFFKAGFVWRLRGGQL--QPGYPALASRHWQGLPS 341


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  294 bits (753), Expect = 1e-79
 Identities = 176/462 (38%), Positives = 237/462 (51%), Gaps = 53/462 (11%)

Query: 36  EAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGV 95
           E +L+ Y Y P        + +  S++  +  MQ F+GL+VTGK D +T+  M++PRCGV
Sbjct: 40  ERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98

Query: 96  PDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESAT 155
           PD         V       + LKW    +T+ I NYTP +      +A +KAF+VW   T
Sbjct: 99  PD---------VGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVT 149

Query: 156 PLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHF 215
           PL F  +        H+  ADIMI F    HGD  PFDG  G LAHA+ PGPN GGD HF
Sbjct: 150 PLNFTRL--------HDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHF 201

Query: 216 DSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDD 275
           D  E WT  ++   G ++FLVA HE GH+LGL+HS DP A+M P Y +    +F+LPDDD
Sbjct: 202 DDDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDD 258

Query: 276 RRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDG--NFDTVAMLRGEM 333
            +GIQ LYG     P    P P+    P  PDK          CD   + D +  LRGE 
Sbjct: 259 VQGIQSLYG-----PGDEDPNPK---HPKTPDK----------CDPSLSLDAITSLRGET 300

Query: 334 FVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVF-FKGDKHWVFDE 392
            +FK+R+FWR+   QV D        FW  LP  I+ AYE      +F F+G K W  + 
Sbjct: 301 MIFKDRFFWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNG 359

Query: 393 ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKN 452
             +  GYPK I ELG      KI AA+ +   GKT  F GN+ +R+++    +D +YP+ 
Sbjct: 360 YDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRL 419

Query: 453 IKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE 494
           I+            F G  +     Y+ N Y  F N  ++ E
Sbjct: 420 IE----------EDFPGIGDKVDAVYEKNGYIYFFNGPIQFE 451


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  294 bits (752), Expect = 2e-79
 Identities = 181/450 (40%), Positives = 243/450 (54%), Gaps = 42/450 (9%)

Query: 65  IAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEI 124
           I  MQKF GL+VTGK D+DT++ MR+PRCGVPD         V   R      KW+   +
Sbjct: 64  IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPD---------VGHFRTFPGIPKWRKTHL 114

Query: 125 TFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEG 184
           T+ I NYTP + + A   A+ KA +VWE  TPL F  +        +E +ADIMI FA  
Sbjct: 115 TYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRL--------YEGEADIMISFAVR 166

Query: 185 FHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHA 244
            HGD  PFDG G  LAHAY PGP I GD HFD  E WT   +D  G ++FLVA HE+GH+
Sbjct: 167 EHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHS 223

Query: 245 LGLEHSSDPSAIMAPFYQWM-DTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRP 303
           LGL HS++  A+M P Y  + D   F L  DD  GIQ LYG          P P +   P
Sbjct: 224 LGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYG----------PPPDSPETP 273

Query: 304 SVPDKPKNPTYG-PNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF 360
            VP +P  P  G P  CD   +FD V+ LRGE+ +FK+R FWR ++ + ++     I  F
Sbjct: 274 LVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWR-KSLRKLEPELHLISSF 332

Query: 361 WRGLPASINTAYERKDGKFVF-FKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAAL 419
           W  LP+ ++ AYE      VF FKG++ W      +  GYP+ I  LG      KIDAA+
Sbjct: 333 WPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAI 392

Query: 420 FWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTYFY 478
                 KTYFF  +KY+RF+E+  +++  +PK I + + GI       F   +  F YF+
Sbjct: 393 SDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVF--EEFGFFYFF 450

Query: 479 KGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
            G+   +F+    KV      ++   W+ C
Sbjct: 451 TGSSQLEFDPNAKKVTHTLKSNS---WLNC 477


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  291 bits (746), Expect = 9e-79
 Identities = 169/465 (36%), Positives = 250/465 (53%), Gaps = 43/465 (9%)

Query: 25  LGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADT 84
           + S + ++ + + +L+++  LP    ++  +     +   +  MQ+F+GL VTGK + +T
Sbjct: 23  VSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEET 82

Query: 85  MKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAI 144
           +  M++PRCGVPD  G  +              KW+   +T+ I+NYTP++ E     AI
Sbjct: 83  LDMMKKPRCGVPDSGGFMLTPG---------NPKWERTNLTYRIRNYTPQLSEAEVERAI 133

Query: 145 RKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYF 204
           + AF +W  A+PL F  +         + +ADI I F +  HGD++PFDG  G LAHA+ 
Sbjct: 134 KDAFELWSVASPLIFTRIS--------QGEADINIAFYQRDHGDNSPFDGPNGILAHAFQ 185

Query: 205 PGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWM 264
           PG  IGGD HFD+ E WT  + + N   +FLVA HE GH+LGL HSSDP A+M P Y + 
Sbjct: 186 PGQGIGGDAHFDAEETWTNTSANYN---LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFR 242

Query: 265 DTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFD 324
           +T N+ LP DD  GIQ +YG  S      P QP   S P    KP +P+         FD
Sbjct: 243 ETSNYSLPQDDIDGIQAIYGLSSN-----PIQPTGPSTP----KPCDPSL-------TFD 286

Query: 325 TVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVF-FK 383
            +  LRGE+  FK+R+FWR R+ Q+       I  FW  LP  I  AYE  D   +F FK
Sbjct: 287 AITTLRGEILFFKDRYFWR-RHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFK 345

Query: 384 GDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELR 443
           G+++W      +  GYPK I   G       IDAA+F+    KTYFF  ++++R++ + +
Sbjct: 346 GNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQ 403

Query: 444 AVDSEYPKNIK-VWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFN 487
            ++  YPK+I   + GI       F    E F + + G +Y+ F+
Sbjct: 404 FMEPGYPKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  290 bits (743), Expect = 2e-78
 Identities = 188/508 (37%), Positives = 262/508 (51%), Gaps = 52/508 (10%)

Query: 12  LLPLLTLGTALASLGSAQSSSFSP------EAWLQQYGYLPPGDLR-THTQRSPQSLSAA 64
           LL LL   TA  +L    S+S         E +L+++  L    L  T  + S   +   
Sbjct: 4   LLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEK 63

Query: 65  IAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEI 124
           I  MQ F GL+VTG+ D  T++ M  PRCGVPD         V   R    G  W+ + I
Sbjct: 64  IQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPD---------VHHFREMPGGPVWRKHYI 114

Query: 125 TFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEG 184
           T+ I NYTP +       AIRKAF+VW + TPL+F ++        +   ADI++ FA G
Sbjct: 115 TYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKI--------NTGMADILVVFARG 166

Query: 185 FHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHA 244
            HGD   FDG+GG LAHA+ PG  IGGD HFD  E WT  +    G ++FL AVHE+GH+
Sbjct: 167 AHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHS---GGTNLFLTAVHEIGHS 223

Query: 245 LGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPS 304
           LGL HSSDP A+M P Y+++D   F L  DD RGIQ LYG            P+   R  
Sbjct: 224 LGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG-----------DPKENQRLP 272

Query: 305 VPDKPKNPTYGPNICDGN--FDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWR 362
            PD  +     P +CD N  FD V  +  ++F FK+R+FW   + +      + I   W 
Sbjct: 273 NPDNSE-----PALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL-ISSLWP 326

Query: 363 GLPASINTAYERKDGKFVF-FKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFW 421
            LP+ I  AYE +    VF FK DK+W+      EP YPK I   G      KIDAA+F 
Sbjct: 327 TLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFN 386

Query: 422 MPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTYFYKG 480
               +TYFF  N+Y+R++E  + +D  YPK I K ++GI       F   ++ + YF++G
Sbjct: 387 PRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYY-YFFQG 445

Query: 481 NKYWKFNNQKLKVEPGYPKSALRDWMGC 508
           +  ++++    ++      ++   W GC
Sbjct: 446 SNQFEYDFLLQRITKTLKSNS---WFGC 470


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  289 bits (740), Expect = 4e-78
 Identities = 183/509 (35%), Positives = 267/509 (52%), Gaps = 50/509 (9%)

Query: 12  LLPLLTLGTALASLGSAQSSSFS-----PEAWLQQYGYLPPG-DLRTHTQRSPQSLSAAI 65
           L+  L   TA  SL +A   ++       +A+L +Y     G  +     R   S+   I
Sbjct: 13  LIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKI 72

Query: 66  AAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEIT 125
             +Q F+GLQVTGK D  TM  +++PRCGVPD         V   R      KW+ N +T
Sbjct: 73  KELQAFFGLQVTGKLDQTTMNVIKKPRCGVPD---------VANYRLFPGEPKWKKNTLT 123

Query: 126 FCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGF 185
           + I  YTP +      +A+  A + W SA PL F  +        +  +ADIMI F  G 
Sbjct: 124 YRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRI--------NSGEADIMISFENGD 175

Query: 186 HGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHAL 245
           HGDS PFDG  G LAHA+ PG  +GGDTHFD+AE WT+     NG ++F VA HE GHAL
Sbjct: 176 HGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT---NGFNLFTVAAHEFGHAL 232

Query: 246 GLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSV 305
           GL HS+DPSA+M P Y++ +   F LP DD +GIQ LYG          P+     +P++
Sbjct: 233 GLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYG----------PRKVFLGKPTL 282

Query: 306 PDKPKNPTYGPNICD--GNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRG 363
           P  P +    P++CD   +FD V ML  E+ +FK+R FWR + +      P  I   +  
Sbjct: 283 PHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQ 342

Query: 364 LPASINTAYE-RKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWM 422
           L ++++ AYE  + G   FFKG  +W+     ++ G P+ I + G      +IDAA++  
Sbjct: 343 LMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLR 401

Query: 423 PNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEV--FTYFYK 479
              KT FF G++YY ++E  R ++ +YPKN  + + G+     G    + E+  + YF+ 
Sbjct: 402 EPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGV----NGQIDAAVELNGYIYFFS 457

Query: 480 GNKYWKFNNQKLKVEPGYPKSALRDWMGC 508
           G K +K++ +K  V      S+   W+GC
Sbjct: 458 GPKTYKYDTEKEDVVSVVKSSS---WIGC 483


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  281 bits (718), Expect = 2e-75
 Identities = 181/484 (37%), Positives = 255/484 (52%), Gaps = 42/484 (8%)

Query: 11  LLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQK 70
           L LP+ +      +     S+    + +L++Y Y    D++   ++    +   I  MQK
Sbjct: 10  LCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKY-YNLEKDVKQFRRKDSNLIVKKIQGMQK 68

Query: 71  FYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGL-KWQHNEITFCIQ 129
           F GL+VTGK D DT++ MR+PRCGVPD               +  G+ KW+   +T+ I 
Sbjct: 69  FLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFS----------SFPGMPKWRKTHLTYRIV 118

Query: 130 NYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDS 189
           NYTP +   A   AI KA +VWE  TPL F  +        +E +ADIMI FA   HGD 
Sbjct: 119 NYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRL--------YEGEADIMISFAVKEHGDF 170

Query: 190 TPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEH 249
             FDG G  LAHAY PGP + GD HFD  E WT   ED +G ++FLVA HELGH+LGL H
Sbjct: 171 YSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSLGLFH 227

Query: 250 SSDPSAIMAPFY-QWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDK 308
           S++  A+M P Y  + +   F L  DD  GIQ LYG          P P +T  P VP K
Sbjct: 228 SANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYG----------PPPASTEEPLVPTK 277

Query: 309 P-KNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLP 365
              + +  P  CD   +FD ++ LRGE   FK+R+FWR R++   +     I  FW  LP
Sbjct: 278 SVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWR-RSHWNPEPEFHLISAFWPSLP 336

Query: 366 ASINTAYERKDGKFVF-FKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPN 424
           + ++ AYE      VF FKG++ W      ++ GYP+ I  LG      KIDAA+     
Sbjct: 337 SYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEK 396

Query: 425 GKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIP-ESPRGSFMGSDEVFTYFYKGNKY 483
            KTYFF  +KY+RF+E  ++++  +P+ I   +  P   P+   +     F YF+ G+  
Sbjct: 397 KKTYFFAADKYWRFDENSQSMEQGFPRLIA--DDFPGVEPKVDAVLQAFGFFYFFSGSSQ 454

Query: 484 WKFN 487
           ++F+
Sbjct: 455 FEFD 458


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  272 bits (696), Expect = 5e-73
 Identities = 183/497 (36%), Positives = 253/497 (50%), Gaps = 57/497 (11%)

Query: 7   PPRCLLLPLLTLGTAL-ASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAI 65
           PP  LLL    +  +  A+L + +      + +L++Y  L     +   +R+   +   +
Sbjct: 5   PPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKL 64

Query: 66  AAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEIT 125
             MQ+F+GL+VTGK DA+T+K M++PRCGVPD         V +        +W+   +T
Sbjct: 65  KQMQEFFGLKVTGKPDAETLKVMKQPRCGVPD---------VAQFVLTEGNPRWEQTHLT 115

Query: 126 FCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGF 185
           + I+NYTP +       AI KAF++W + TPL F +V         E QADIMI F  G 
Sbjct: 116 YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVRGD 167

Query: 186 HGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHAL 245
           H D++PFDG GG LAHA+ PGP IGGD HFD  E WT    + N   +  VA HELGH+L
Sbjct: 168 HRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN---LHRVAAHELGHSL 224

Query: 246 GLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSV 305
           GL HS+D  A+M P Y +  + +  L  DD  GIQ +YG                 R   
Sbjct: 225 GLSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG-----------------RSQN 265

Query: 306 PDKPKNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMP----IGQ 359
           P +P  P   P  CD    FD +  +RGE+  FK+R++ R         YP      I  
Sbjct: 266 PVQPIGP-QTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN-----PFYPEVELNFISV 319

Query: 360 FWRGLPASINTAYERKDGKFV-FFKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDA 417
           FW  LP  +  AYE  D   V FFKG+K+W     ++  GYPK I    G       IDA
Sbjct: 320 FWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDA 379

Query: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTY 476
           AL     GKTYFF  NKY+R++E  R++D  YPK I   + GI       FM   + F Y
Sbjct: 380 ALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFY 437

Query: 477 FYKGNKYWKFNNQKLKV 493
           F+ G + +KF+ +  ++
Sbjct: 438 FFHGTRQYKFDPKTKRI 454


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  268 bits (686), Expect = 8e-72
 Identities = 172/435 (39%), Positives = 228/435 (52%), Gaps = 56/435 (12%)

Query: 68  MQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFC 127
           MQ+F+GL+VTGK DA+T+K M++PRCGVPD         V +        +W+   +T+ 
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPD---------VAQFVLTEGNPRWEQTHLTYR 51

Query: 128 IQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHG 187
           I+NYTP +       AI KAF++W + TPL F +V         E QADIMI F  G H 
Sbjct: 52  IENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVRGDHR 103

Query: 188 DSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGL 247
           D++PFDG GG LAHA+ PGP IGGD HFD  E WT    + N   +  VA HELGH+LGL
Sbjct: 104 DNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN---LHRVAAHELGHSLGL 160

Query: 248 EHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPD 307
            HS+D  A+M P Y +  + +  L  DD  GIQ +YG                 R   P 
Sbjct: 161 SHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG-----------------RSQNPV 201

Query: 308 KPKNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMP----IGQFW 361
           +P  P   P  CD    FD +  +RGE+  FK+R++ R         YP      I  FW
Sbjct: 202 QPIGP-QTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN-----PFYPEVELNFISVFW 255

Query: 362 RGLPASINTAYERKDGKFV-FFKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDAAL 419
             LP  +  AYE  D   V FFKG+K+W     ++  GYPK I    G       IDAAL
Sbjct: 256 PQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAAL 315

Query: 420 FWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTYFY 478
                GKTYFF  NKY+R++E  R++D  YPK I   + GI       FM   + F YF+
Sbjct: 316 SEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFYFF 373

Query: 479 KGNKYWKFNNQKLKV 493
            G + +KF+ +  ++
Sbjct: 374 HGTRQYKFDPKTKRI 388


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  260 bits (664), Expect = 3e-69
 Identities = 167/456 (36%), Positives = 231/456 (50%), Gaps = 46/456 (10%)

Query: 36  EAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGV 95
           +A+L Q+  L          ++   +   I  MQ F+GL VTGK D++T++ M+ PRCGV
Sbjct: 34  QAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGV 93

Query: 96  PDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESAT 155
           PD         V +  Y + G  W+   +T+ I NYTP +   A  EAI++   VW   T
Sbjct: 94  PD---------VGQYGYTLPG--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVT 142

Query: 156 PLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTP-FDGEGGFLAHAYFPGPNIGGDTH 214
           PL+F ++            ADIMI F    HG     FDG  G L HA+ PGP +GGDTH
Sbjct: 143 PLKFTKISKGI--------ADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTH 194

Query: 215 FDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDD 274
           FD  E WT   +D  G ++FLVA HE GHALGL HS+D +A+M P Y  +D   + L  D
Sbjct: 195 FDEDENWT---KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQD 251

Query: 275 DRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGN--FDTVAMLRGE 332
           D  GIQ +YGG                 P  P KPK PT  P+ CD +  FD +   R E
Sbjct: 252 DINGIQSIYGG----------------LPKEPAKPKEPTI-PHACDPDLTFDAITTFRRE 294

Query: 333 MFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE 392
           +  FK R  WR+  + + D     I  FW  LPA +  AYE    K + FK +  W+   
Sbjct: 295 VMFFKGRHLWRIYYD-ITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRG 353

Query: 393 ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKN 452
            ++ P YPK I  LG      KIDAA+      KTYFF G   +RF+E  + +D  +P+ 
Sbjct: 354 YAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQR 413

Query: 453 -IKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFN 487
            +K + GI      +F      F +F +G+K ++++
Sbjct: 414 VVKHFPGISIRVDAAFQYKG--FFFFSRGSKQFEYD 447


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  256 bits (655), Expect = 3e-68
 Identities = 176/517 (34%), Positives = 254/517 (49%), Gaps = 59/517 (11%)

Query: 12  LLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKF 71
           LLP+   G  L        +  +P  +L QYGYL    L       P+ ++ A+ A Q+ 
Sbjct: 11  LLPMTVSGRVLGL------AEVAPVDYLSQYGYLQK-PLEGSNNFKPEDITEALRAFQEA 63

Query: 72  YGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNY 131
             L V+G+ D  T   MR+PRCG+ D F      N +  +Y + G +W+   +TF I N 
Sbjct: 64  SELPVSGQLDDATRARMRQPRCGLEDPF------NQKTLKYLLLG-RWRKKHLTFRILNL 116

Query: 132 TPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGD--- 188
              +  +    A+R+AF+ W +  PL F+EV            ADI +     FHG    
Sbjct: 117 PSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAG--------AADIRL----SFHGRQSS 164

Query: 189 --STPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALG 246
             S  FDG G  LAHA  P     G  HFD  E WT       G ++ ++A HE+GHALG
Sbjct: 165 YCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWT--EGTYRGVNLRIIAAHEVGHALG 219

Query: 247 LEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVP 306
           L HS    A+MAP Y+     +F L  DD  GIQ LYG +S  P     +   T  P+VP
Sbjct: 220 LGHSRYSQALMAPVYEGY-RPHFKLHPDDVAGIQALYGKKS--PVIRDEEEEETELPTVP 276

Query: 307 DKPKNPTYGPNICDGNFDTVAM-LRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLP 365
             P  P+  P+ C    D + +  RG+ + FK  + W V ++    G    +   W GLP
Sbjct: 277 PVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG--PGPLFRVSALWEGLP 334

Query: 366 ASINTA-YERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPN 424
            +++ A Y  +     FFKGDK W +    + PG+PK +  +        +DAAL+W  N
Sbjct: 335 GNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRV-----EPNLDAALYWPLN 389

Query: 425 GKTYFFRGNKYYRFNEELRAVDSEYPKNIK-VWEGIPESPRGSFMGSDEVFTYFYKGNKY 483
            K + F+G+ Y++++E  R   S YPK IK ++ G+P  P  + M   +   YF+KG  Y
Sbjct: 390 QKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAA-MSWQDGRVYFFKGKVY 448

Query: 484 WKFNNQKLKVEPGYPKSALRDWMGC--------PSGG 512
           W+  NQ+L+VE GYP++   +WM C        PSGG
Sbjct: 449 WRL-NQQLRVEKGYPRNISHNWMHCRPRTIDTTPSGG 484


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  233 bits (595), Expect = 3e-61
 Identities = 165/498 (33%), Positives = 238/498 (47%), Gaps = 49/498 (9%)

Query: 36  EAWLQQYGYLPPGDLRTHTQRSPQS--LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRC 93
           EA+L++YGYL          ++P S   S AI A Q    L V+G  D  T++ M RPRC
Sbjct: 37  EAFLEKYGYL-----NEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRC 91

Query: 94  GVPDK-------------FGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYAT 140
           GV D              F        R+KR+A QG KW    +++ + N+   + E A 
Sbjct: 92  GVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAV 151

Query: 141 YEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDS--TPFDGEGGF 198
             A+R AF++W + + L F E P           ADI + F +G H D     FDG GG 
Sbjct: 152 RGAVRAAFQLWSNVSALEFWEAPAT-------GPADIRLTFFQGDHNDGLGNAFDGPGGA 204

Query: 199 LAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMA 258
           LAHA+ P     G+ HFD  E W++      G ++F+V  HE+GH LGL HS  P A+MA
Sbjct: 205 LAHAFLPRR---GEAHFDQDERWSLSRR--RGRNLFVVLAHEIGHTLGLTHSPAPRALMA 259

Query: 259 PFYQWMDTENFVLPDDDRRGIQQLYGGESG------FPTKMPPQPRTTSRPSVPDKPKNP 312
           P+Y+ +   + +L  DD   +Q LYG   G       P K+     T    S P   +  
Sbjct: 260 PYYKRLG-RDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYS-PQGRRPE 317

Query: 313 TYGPNICDGNFDTVAMLR-GEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASIN-T 370
           T GP  C  +FD + + R  ++++FK   FW V  +  +   P P+ + W GLP +I   
Sbjct: 318 TQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNV-SEPRPLQERWVGLPPNIEAA 376

Query: 371 AYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFF 430
           A    DG F FFKG + W F       G P+  +    GLP    DAALF+ P  +   F
Sbjct: 377 AVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCR--AGGLPRHP-DAALFFPPLRRLILF 433

Query: 431 RGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQK 490
           +G +YY        V+  YP++++ W GIPE   G+    D     F++ ++YW+ +  K
Sbjct: 434 KGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSI-IFFRDDRYWRLDQAK 492

Query: 491 LKVEPGYPKSALRDWMGC 508
           L+       +    WMGC
Sbjct: 493 LQATTSGRWATELPWMGC 510


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  199 bits (505), Expect = 8e-51
 Identities = 114/282 (40%), Positives = 156/282 (55%), Gaps = 18/282 (6%)

Query: 230 GNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGF 289
           G  +FLVA HE GHA+GLEHS DP A+MAP Y +  T+NF L  DD +GIQ+LYG     
Sbjct: 344 GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQDDIKGIQELYGASPDI 401

Query: 290 PTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQV 349
                P P  T  P  P+  K         D  FD +A +RGE+F FK+R+ WR    + 
Sbjct: 402 DLGTGPTP--TLGPVTPEICKQ--------DIVFDGIAQIRGEIFFFKDRFIWRTVTPRD 451

Query: 350 MDGYPMPIGQFWRGLPASINTAYER-KDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGR 408
               P+ +  FW  LP  I+  YE  ++ K VFF G+++W++  ++LE GYPK +  LG 
Sbjct: 452 KPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGL 511

Query: 409 GLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSF 467
                ++DAA  W  N KTY F G+K++R+NE  + +D  +PK I   W  IP++     
Sbjct: 512 PPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVV 571

Query: 468 MGSDEVFTYFYKGNKYWKFNNQKLK-VEPGYPKSALRDWMGC 508
                  +YF+KG  Y K  NQ LK V+ G  KS   DW+GC
Sbjct: 572 DLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKS---DWLGC 610



 Score =  135 bits (339), Expect = 1e-31
 Identities = 69/163 (42%), Positives = 91/163 (55%), Gaps = 17/163 (10%)

Query: 61  LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ 120
           L   +  MQKF+GL  TG  D +T++ MR+PRCG PD         V    +  +  KW 
Sbjct: 20  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPD---------VANYNFFPRKPKWD 70

Query: 121 HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF 180
            N+IT+ I  YTP +      +A  +AF+VW   TPLRF  +        H+ +ADIMI 
Sbjct: 71  KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--------HDGEADIMIN 122

Query: 181 FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV 223
           F    HGD  PFDG+ G LAHA+ PG  +GGD+HFD  E WT+
Sbjct: 123 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTL 165


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  199 bits (505), Expect = 8e-51
 Identities = 114/282 (40%), Positives = 156/282 (55%), Gaps = 18/282 (6%)

Query: 230 GNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGF 289
           G  +FLVA HE GHA+GLEHS DP A+MAP Y +  T+NF L  DD +GIQ+LYG     
Sbjct: 394 GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQDDIKGIQELYGASPDI 451

Query: 290 PTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQV 349
                P P  T  P  P+  K         D  FD +A +RGE+F FK+R+ WR    + 
Sbjct: 452 DLGTGPTP--TLGPVTPEICKQ--------DIVFDGIAQIRGEIFFFKDRFIWRTVTPRD 501

Query: 350 MDGYPMPIGQFWRGLPASINTAYER-KDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGR 408
               P+ +  FW  LP  I+  YE  ++ K VFF G+++W++  ++LE GYPK +  LG 
Sbjct: 502 KPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGL 561

Query: 409 GLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSF 467
                ++DAA  W  N KTY F G+K++R+NE  + +D  +PK I   W  IP++     
Sbjct: 562 PPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVV 621

Query: 468 MGSDEVFTYFYKGNKYWKFNNQKLK-VEPGYPKSALRDWMGC 508
                  +YF+KG  Y K  NQ LK V+ G  KS   DW+GC
Sbjct: 622 DLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKS---DWLGC 660



 Score =  135 bits (339), Expect = 1e-31
 Identities = 69/163 (42%), Positives = 91/163 (55%), Gaps = 17/163 (10%)

Query: 61  LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ 120
           L   +  MQKF+GL  TG  D +T++ MR+PRCG PD         V    +  +  KW 
Sbjct: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPD---------VANYNFFPRKPKWD 120

Query: 121 HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF 180
            N+IT+ I  YTP +      +A  +AF+VW   TPLRF  +        H+ +ADIMI 
Sbjct: 121 KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--------HDGEADIMIN 172

Query: 181 FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV 223
           F    HGD  PFDG+ G LAHA+ PG  +GGD+HFD  E WT+
Sbjct: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTL 215


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  182 bits (461), Expect = 1e-45
 Identities = 103/259 (39%), Positives = 136/259 (52%), Gaps = 19/259 (7%)

Query: 29  QSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAM 88
           ++   S   W Q   YL    L     ++  SL A +  MQKF+GL +TG  ++  ++ M
Sbjct: 23  EAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIM 82

Query: 89  RRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAF 148
           ++PRCGVPD     +  N           KW    +T+ I +YT  +        + KA 
Sbjct: 83  QKPRCGVPDVAEYSLFPN---------SPKWTSKVVTYRIVSYTRDLPHITVDRLVSKAL 133

Query: 149 RVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPN 208
            +W    PL FR+V +          ADIMI FA G HGDS PFDG G  LAHA+ PG  
Sbjct: 134 NMWGKEIPLHFRKVVWG--------TADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTG 185

Query: 209 IGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTEN 268
           +GGD HFD  E WT  +    G +    A HELGH+LG+ HSSDP+A+M P Y   D +N
Sbjct: 186 LGGDAHFDEDERWT--DGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQN 243

Query: 269 FVLPDDDRRGIQQLYGGES 287
           F L  DD +GIQ+LYG  S
Sbjct: 244 FKLSQDDIKGIQKLYGKRS 262


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  147 bits (372), Expect = 2e-35
 Identities = 147/504 (29%), Positives = 210/504 (41%), Gaps = 123/504 (24%)

Query: 60  SLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKF-----------GAEIKANVR 108
           +L+ A+   Q+   L  +G+ DA T+ AM RPRCGVPD             G   +A  R
Sbjct: 84  ALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSR 143

Query: 109 RKRYAIQGLK---WQHNEITF--CIQNYTPK------VGEYATYEA--------IRKAFR 149
           R   A   L    WQ          Q ++ +      +GE  + +         +  AFR
Sbjct: 144 RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFR 203

Query: 150 VWESATPLRFRE---VPYAYIREGHEKQADIMIFFAEGFH-GDSTPFDGEGGFLAHAYFP 205
           +W   TPL FRE    P A +        DI + F  G H G    FDG G   AHA+  
Sbjct: 204 MWSEVTPLDFREDLAAPGAAV--------DIKLGFGRGRHLGCPRAFDGSGQEFAHAWRL 255

Query: 206 GPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMD 265
           G     D HFD  E +T    D  G  +  VAVHE+GH LGL H+    +IM P Y   +
Sbjct: 256 G-----DIHFDDDEHFTPPTSD-TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQE 309

Query: 266 TENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDT 325
              F L   DR+ IQ+LYG                                  C+G+FDT
Sbjct: 310 PA-FELDWSDRKAIQKLYGS---------------------------------CEGSFDT 335

Query: 326 V-------------AMLRGEMFVFKERWFW--RVRNNQVMDGYPMPIGQFWRGLP----- 365
                          M+R   + F+  W+W    RNN+   G P+ I   W G+P     
Sbjct: 336 AFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNID 395

Query: 366 ASINTAYERKDGKFVFFKGDKHWVFD--------EASLEPGYPKHIKELGRGLPTDKIDA 417
           A ++    ++D ++ FF+G+++W +D        E      YPK I E   G+P+  +D 
Sbjct: 396 AFVHIWTWKRDERY-FFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS-PLDT 453

Query: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEG-IPESPRGSFMGSDEVF- 474
           A +       YFF+ +  + F+     V + YPK I +V+   IP++    F   D  + 
Sbjct: 454 AFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQN--HPFRNIDSAYY 511

Query: 475 ------TYFYKGNKYWKFNNQKLK 492
                  +F+KGN YWK  N K K
Sbjct: 512 SYAYNSIFFFKGNAYWKVVNDKDK 535



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 14/96 (14%)

Query: 427 TYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFT------YFYKG 480
           TYFFR + Y+ +  E R   + Y   I++  G P  P  +      ++T      YF++G
Sbjct: 356 TYFFRNSWYWLY--ENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQG 413

Query: 481 NKYWKFNNQK----LKVEPG--YPKSALRDWMGCPS 510
           N+YW++++ K     + E G  YPK     + G PS
Sbjct: 414 NQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS 449


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  135 bits (341), Expect = 8e-32
 Identities = 84/227 (37%), Positives = 115/227 (50%), Gaps = 35/227 (15%)

Query: 11  LLLPLLTLGTALASLGSAQSSSFS--------------PEAWLQQYGYLPPGDLRTHTQR 56
           L+L LL LG   A+    QS+                  E +L +YGY    ++R  ++ 
Sbjct: 7   LVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESK- 65

Query: 57  SPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQG 116
              SL  A+  +QK   L  TG+ D+ T+KAMR PRCGVPD         + R +     
Sbjct: 66  ---SLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPD---------LGRFQTFEGD 113

Query: 117 LKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQAD 176
           LKW H+ IT+ IQNY+  +      +A  +AF +W + TPL F  V        + + AD
Sbjct: 114 LKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRV--------YSRDAD 165

Query: 177 IMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV 223
           I+I F    HGD  PFDG+ G LAHA+ PGP I GD HFD  E W++
Sbjct: 166 IVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSL 212



 Score =  116 bits (291), Expect = 5e-26
 Identities = 95/318 (29%), Positives = 147/318 (46%), Gaps = 50/318 (15%)

Query: 213 THFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLP 272
           ++FDS + W    +   G  +FLVA HE GHALGL+HSS P A+M P Y++  TE   L 
Sbjct: 377 SNFDSDKKWGFCPDQ--GYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRF--TEGPPLH 432

Query: 273 DDDRRGIQQLYGG----ESGFPTKMPPQPRT------TSRPSV---------PDKPKN-- 311
            DD  GI+ LYG     E   PT   PQP        T  P+V         P  P +  
Sbjct: 433 KDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAG 492

Query: 312 ----PTYGPNI------------CDGN-FDTVAMLRGEMFVFKERWFWRVRNNQ-VMDGY 353
               PT GP+             C+ N FD +A +  ++++FK+  +WR    +      
Sbjct: 493 PTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQG 552

Query: 354 PMPIGQFWRGLPASINTAY-ERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPT 412
           P  I   W  LP  +++ + ER   K  FF G + WV+  AS+    P+ + +LG G   
Sbjct: 553 PFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGADV 610

Query: 413 DKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSD 471
            ++  AL     GK   F G + +RF+ + + VD      + +++ G+P      F   +
Sbjct: 611 AQVTGAL-RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYRE 669

Query: 472 EVFTYFYKGNKYWKFNNQ 489
           +   YF +   YW+ +++
Sbjct: 670 K--AYFCQDRFYWRVSSR 685


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  131 bits (329), Expect = 2e-30
 Identities = 76/208 (36%), Positives = 105/208 (50%), Gaps = 20/208 (9%)

Query: 77  TGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVG 136
           T   D      + +P CGVPD  G++   +  R        KW  + +T+ I NY   + 
Sbjct: 66  TDLLDMQMHALLHQPHCGVPD--GSDTSISPGR-------CKWNKHTLTYRIINYPHDMK 116

Query: 137 EYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEG 196
             A  ++I  A  +W + TPL F++V            ADI + F +  H D  PFDG G
Sbjct: 117 PSAVKDSIYNAVSIWSNVTPLIFQQV--------QNGDADIKVSFWQWAHEDGWPFDGPG 168

Query: 197 GFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAI 256
           G L HA+ P     G  HFD  E W+  +    G ++FLVA HE+GH+LGL+HS + S+I
Sbjct: 169 GILGHAFLPNSGNPGVVHFDKNEHWSASD---TGYNLFLVATHEIGHSLGLQHSGNQSSI 225

Query: 257 MAPFYQWMDTENFVLPDDDRRGIQQLYG 284
           M P Y + D   F L  DD + IQ LYG
Sbjct: 226 MYPTYWYHDPRTFQLSADDIQRIQHLYG 253


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 68/195 (34%), Positives = 92/195 (47%), Gaps = 33/195 (16%)

Query: 108 RRKRYAIQG--LKWQHNEITFCIQNYTPKV-GEYATYEAIRKAFRVWESATPLRFREVPY 164
           RR+RY +    L+W H  +T+ I ++   +     T  A+  AFR+W   +P  FREV  
Sbjct: 75  RRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREV-- 132

Query: 165 AYIREGHEKQADIMIFFAEGFHGDSTP------FDGEGGFLAHAYFPGPNIGGDTHFDSA 218
                  E+ +D+ I F    H D         FDG  G LAHA+FP P+  G  HFD +
Sbjct: 133 -----APEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFP-PH--GGIHFDDS 184

Query: 219 EPWTV---RNEDLNG---NDIFLVAVHELGHALGLEHSSDPSAIM---APFYQWMDTENF 269
           E W +   R     G    D+  VA HE+GHALGL HS    A+M   A    W      
Sbjct: 185 EYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWK----- 239

Query: 270 VLPDDDRRGIQQLYG 284
            L  D+  G+ +LYG
Sbjct: 240 ALSQDELWGLHRLYG 254


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 63/222 (28%), Positives = 102/222 (45%), Gaps = 28/222 (12%)

Query: 301 SRPSV--PDKPKNPTYGPNICDGN-FDTVAMLR-GEMFVFKERWFWRVRNNQVMDGYPMP 356
           SRP    P +P+ P     +C G  FD    L+ G +F F+ ++ + +    V  GYP  
Sbjct: 137 SRPETLHPGRPQPPAE-EELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKL 195

Query: 357 IGQFWRGLPASINTAYERKD--GKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDK 414
           I   W G+   I+ A+ R +  GK   FKG ++W F++  L+P YP++I +   G+P D 
Sbjct: 196 IRDVW-GIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIP-DN 253

Query: 415 IDAAL-----FWMPNGKTYFFRGNKY--YRFNEELRAVDSEYPKNIKVWEGIPESPRGSF 467
           +DAAL      +    + YFF+G +Y  Y+F  +    + E      V+E      R S+
Sbjct: 254 VDAALALPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSW 313

Query: 468 MGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCP 509
              +++F   + G         +       P+   RDW G P
Sbjct: 314 ---EDIFELLFWG---------RTSAGTRQPQFISRDWHGVP 343



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 15/40 (37%), Positives = 27/40 (67%), Gaps = 3/40 (7%)

Query: 476 YFYKGNKYWKFNNQKLKVE---PGYPKSALRDWMGCPSGG 512
           +F+ G+KY++ N +  +V+   P YP+S  + W+GCP+ G
Sbjct: 437 FFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPAPG 476



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 4/42 (9%)

Query: 423 PNGKTYFFRGNKYYRFNEELRAVDS---EYPKNI-KVWEGIP 460
           P    +FF G+KYYR N   R VD+    YP++I + W G P
Sbjct: 432 PIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCP 473


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 59/190 (31%), Positives = 86/190 (45%), Gaps = 31/190 (16%)

Query: 12  LLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKF 71
           LLP+   G  L        +  +P  +L QYGYL    L       P+ ++ A+ A Q+ 
Sbjct: 11  LLPMTVSGRVLGL------AEVAPVDYLSQYGYLQK-PLEGSNNFKPEDITEALRAFQEA 63

Query: 72  YGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNY 131
             L V+G+ D  T   MR+PRCG+ D F      N +  +Y + G +W+   +TF I N 
Sbjct: 64  SELPVSGQLDDATRARMRQPRCGLEDPF------NQKTLKYLLLG-RWRKKHLTFRILNL 116

Query: 132 TPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGD--- 188
              +  +    A+R+AF+ W +  PL F+EV            ADI +     FHG    
Sbjct: 117 PSTLPPHTARAALRQAFQDWSNVAPLTFQEV--------QAGAADIRL----SFHGRQSS 164

Query: 189 --STPFDGEG 196
             S  FDG G
Sbjct: 165 YCSNTFDGPG 174


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 44/126 (34%), Positives = 62/126 (49%), Gaps = 20/126 (15%)

Query: 118 KWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADI 177
           KWQ +      QNY P + +     A  KAF +W +A+ L F            E + DI
Sbjct: 22  KWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTR--------DFESEGDI 67

Query: 178 MIFFA--EGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFL 235
           ++ F      H D++PF G  G LAHA+ PGP IGGD HFD+ E    R +D   +  ++
Sbjct: 68  ILSFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDE---TRTKDFRSSKHWV 123

Query: 236 VAVHEL 241
           V   +L
Sbjct: 124 VQEDQL 129



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 32/79 (40%), Positives = 46/79 (58%), Gaps = 1/79 (1%)

Query: 382 FKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNE 440
           F+  KHWV  E  L  GYP+ +           KIDAA++    GKT+FF  N+Y+R++E
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 441 ELRAVDSEYPKNIKVWEGI 459
            +++VD+ YPK I    GI
Sbjct: 176 NMQSVDAGYPKIIDDLPGI 194



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 25/79 (31%), Positives = 43/79 (54%), Gaps = 11/79 (13%)

Query: 336 FKERWFWRVRNNQVMDGYPMPIGQFW------RGLPASINTAYERKDGKFVFFKGDKHWV 389
           F+    W V+ +Q++ GYP  +   +      + + A+I   YE+  GK  FF  +++W 
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAI---YEKDTGKTHFFVANEYWR 172

Query: 390 FDE--ASLEPGYPKHIKEL 406
           +DE   S++ GYPK I +L
Sbjct: 173 YDENMQSVDAGYPKIIDDL 191



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 5/77 (6%)

Query: 426 KTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPR---GSFMGSDEVFTYFYKGNK 482
           +T  FR +K++   E+   + S YP+++      PE  +    +    D   T+F+  N+
Sbjct: 112 RTKDFRSSKHWVVQED--QLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANE 169

Query: 483 YWKFNNQKLKVEPGYPK 499
           YW+++     V+ GYPK
Sbjct: 170 YWRYDENMQSVDAGYPK 186


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 44/130 (33%), Positives = 63/130 (48%), Gaps = 14/130 (10%)

Query: 114 IQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEK 173
           ++ LK   N      QNY P + +     A  KAF +W +A+ L F            E 
Sbjct: 172 LEKLKQMQNFFGLKDQNYMPNLPQEDVDRATGKAFELWSNASALTFTR--------DFES 223

Query: 174 QADIMIFFA--EGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGN 231
           + DI++ F      H D++PF G  G LAHA+ PGP IGGD HFD+ E    R +D   +
Sbjct: 224 EGDIILSFVFLADLH-DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDE---TRTKDFRSS 279

Query: 232 DIFLVAVHEL 241
             ++V   +L
Sbjct: 280 KHWVVQEDQL 289



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 32/79 (40%), Positives = 46/79 (58%), Gaps = 1/79 (1%)

Query: 382 FKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNE 440
           F+  KHWV  E  L  GYP+ +           KIDAA++    GKT+FF  N+Y+R++E
Sbjct: 276 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 335

Query: 441 ELRAVDSEYPKNIKVWEGI 459
            +++VD+ YPK I    GI
Sbjct: 336 NMQSVDAGYPKIIDDLPGI 354



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 25/79 (31%), Positives = 43/79 (54%), Gaps = 11/79 (13%)

Query: 336 FKERWFWRVRNNQVMDGYPMPIGQFW------RGLPASINTAYERKDGKFVFFKGDKHWV 389
           F+    W V+ +Q++ GYP  +   +      + + A+I   YE+  GK  FF  +++W 
Sbjct: 276 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAI---YEKDTGKTHFFVANEYWR 332

Query: 390 FDE--ASLEPGYPKHIKEL 406
           +DE   S++ GYPK I +L
Sbjct: 333 YDENMQSVDAGYPKIIDDL 351



 Score = 37.0 bits (84), Expect = 0.050
 Identities = 21/77 (27%), Positives = 39/77 (50%), Gaps = 5/77 (6%)

Query: 426 KTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPR---GSFMGSDEVFTYFYKGNK 482
           +T  FR +K++   E+   + S YP+++      PE  +    +    D   T+F+  N+
Sbjct: 272 RTKDFRSSKHWVVQED--QLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANE 329

Query: 483 YWKFNNQKLKVEPGYPK 499
           YW+++     V+ GYPK
Sbjct: 330 YWRYDENMQSVDAGYPK 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.139    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,471,108
Number of Sequences: 37866
Number of extensions: 1358505
Number of successful extensions: 4143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3706
Number of HSP's gapped (non-prelim): 150
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.