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Search of human proteins with 132814467
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|132814467 glutamyl aminopeptidase [Homo sapiens]
(957 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|132814467 glutamyl aminopeptidase [Homo sapiens] 1958 0.0
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 570 e-162
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 538 e-153
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 538 e-153
gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 520 e-147
gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 520 e-147
gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 504 e-142
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 482 e-136
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 477 e-134
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 477 e-134
gi|194239713 laeverin [Homo sapiens] 431 e-120
gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 93 1e-18
gi|40316915 arginyl aminopeptidase [Homo sapiens] 76 2e-13
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 58 5e-08
gi|4507347 TBP-associated factor 2 [Homo sapiens] 42 0.004
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 35 0.44
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 35 0.44
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 35 0.44
gi|133922582 zinc finger protein 358 [Homo sapiens] 35 0.44
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 34 0.75
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 34 0.75
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 33 0.98
gi|148747351 protein kinase C and casein kinase substrate in neu... 32 2.2
gi|26051231 lactamase, beta isoform a [Homo sapiens] 32 2.2
gi|26051233 lactamase, beta isoform b [Homo sapiens] 32 2.2
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 32 2.8
gi|31711992 dihydrolipoamide S-acetyltransferase [Homo sapiens] 32 2.8
gi|54607014 TBC1 domain family, member 25 [Homo sapiens] 32 2.8
gi|239757409 PREDICTED: similar to zinc finger protein 208 [Homo... 32 3.7
gi|239746371 PREDICTED: similar to zinc finger protein 208 [Homo... 32 3.7
>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
Length = 957
Score = 1958 bits (5072), Expect = 0.0
Identities = 957/957 (100%), Positives = 957/957 (100%)
Query: 1 MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL 60
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL
Sbjct: 1 MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL 60
Query: 61 PSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVS 120
PSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVS
Sbjct: 61 PSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVS 120
Query: 121 ISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPS 180
ISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPS
Sbjct: 121 ISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPS 180
Query: 181 SGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKK 240
SGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKK
Sbjct: 181 SGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKK 240
Query: 241 ATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRI 300
ATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRI
Sbjct: 241 ATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRI 300
Query: 301 SNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAME 360
SNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAME
Sbjct: 301 SNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAME 360
Query: 361 NWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFAS 420
NWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFAS
Sbjct: 361 NWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFAS 420
Query: 421 FFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYS 480
FFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYS
Sbjct: 421 FFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYS 480
Query: 481 KGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTR 540
KGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTR
Sbjct: 481 KGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTR 540
Query: 541 QMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSE 600
QMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSE
Sbjct: 541 QMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSE 600
Query: 601 KEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLID 660
KEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLID
Sbjct: 601 KEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLID 660
Query: 661 DAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYF 720
DAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYF
Sbjct: 661 DAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYF 720
Query: 721 QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPV 780
QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPV
Sbjct: 721 QGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPV 780
Query: 781 NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLK 840
NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLK
Sbjct: 781 NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLK 840
Query: 841 DTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFN 900
DTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFN
Sbjct: 841 DTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFN 900
Query: 901 TELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG 957
TELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
Sbjct: 901 TELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG 957
>gi|157266300 membrane alanine aminopeptidase precursor [Homo
sapiens]
Length = 967
Score = 570 bits (1468), Expect = e-162
Identities = 334/963 (34%), Positives = 524/963 (54%), Gaps = 58/963 (6%)
Query: 26 VVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDES 85
V V I+ L+V ++ + + + P + PS S+T +P+ DQ S
Sbjct: 20 VAAVCTIIALSVVYSQEKNKNANSSPVASTTPS--ASATTNPASATTLDQ---------S 68
Query: 86 GQWKNFRLPDFVNPVHYDLHVKPLLEED-----TYTGTVSISINLSAPTRYLWLHLRETR 140
W +RLP+ + P Y + ++P L + + G+ ++ T + +H ++
Sbjct: 69 KAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLN 128
Query: 141 IT----RLPELKRPSGDQV-QVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGW 195
T L+ G Q + + + EY+VV + L D Y + EF G
Sbjct: 129 YTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVK---DSQYEMDSEFEGE 185
Query: 196 LNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGA 255
L L GFYR+ Y E K + T + DARKSFPCFDEP KA + I++ HPK+ A
Sbjct: 186 LADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTA 245
Query: 256 LSNMPVAKEESV----DDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYV 311
LSNM + K S D W T F + MSTYL+ F V +FD V++ +++G + I+
Sbjct: 246 LSNM-LPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWA 304
Query: 312 QPEQKHTA--EYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRE 369
+P +YA N+T + ++F ++ Y LPK D+I +PDF GAMENWGL+TYRE
Sbjct: 305 RPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRE 364
Query: 370 TNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNH 429
+LL+DP S+SSN++RV TV+AHEL HQWFGN+VT++WW DLWLNEGFAS+ E+LG ++
Sbjct: 365 NSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADY 424
Query: 430 AETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIV---TVTTPDEITSVFDGISYSKGSSIL 486
AE W ++D M+L DV V D+L SSHP+ + TP +I+ +FD ISYSKG+S+L
Sbjct: 425 AEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVL 484
Query: 487 RMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEA-----SRLP--VKEVMDTWT 539
RML ++ + F++G YL + ++N + W L+EA +LP V+++M+ WT
Sbjct: 485 RMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWT 544
Query: 540 RQMGYPVLNVN-GVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNR 598
QMG+PV+ V+ ++Q+ FLLDP +N ++ PS+ Y W +P+ D +
Sbjct: 545 LQMGFPVITVDTSTGTLSQEHFLLDPDSNVTR-PSEFNYVWIVPITSIRDGRQQQDYWLI 603
Query: 599 SEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASL 658
+ L S+ SGN ++ +N + G+YRVNY+ W I T L +H +RA +
Sbjct: 604 DVRAQNDLFST--SGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQI 661
Query: 659 IDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEE 718
I+DAF LA A + +ALN T +L E ++PW+ +S+++Y MF D E+Y ++
Sbjct: 662 INDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMF-DRSEVYGPMKN 720
Query: 719 YFQGQVKPI-----ADSLGWNDAGDH-VTKLLRSSVLGFACKMGDREALNNASSLFEQWL 772
Y + QV P+ ++ W + ++ + + + + AC G E S LF+QW+
Sbjct: 721 YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM 780
Query: 773 NGTVSLPV--NLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVT 830
+ P+ NLR VY + G E W++ EQ++ +L E +KL LA K +
Sbjct: 781 ENPNNNPIHPNLRSTVYCNAIAQGGEE-EWDFAWEQFRNATLVNEADKLRAALACSKELW 839
Query: 831 LLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLG 890
+L+RYL + +LI+ QD + I I+ N G+ + W+++Q NW L N Y + +
Sbjct: 840 ILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFS 899
Query: 891 RIV-TIAEPFNTELQLWQMESFFAKYPQAGAGEKPR--EQVLETVKNNIEWLKQHRNTIR 947
++ + F+TE +L Q+E F + G G R EQ LE K NI+W+K+++ +
Sbjct: 900 NLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVL 959
Query: 948 EWF 950
+WF
Sbjct: 960 QWF 962
>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 538 bits (1387), Expect = e-153
Identities = 311/913 (34%), Positives = 490/913 (53%), Gaps = 56/913 (6%)
Query: 80 ASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRET 139
A+ E W+ RLP V P+HYDL V P L + + I + +S T+++ LH ++
Sbjct: 56 ATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDL 115
Query: 140 RITRLPELKRPSGDQVQVRR---CFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWL 196
IT ++ + Y E + + E+LTP Y + M+F L
Sbjct: 116 EITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLK---YYVAMDFQAKL 172
Query: 197 NGSLVGFYRTTY-TENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGA 255
GFY++TY T G+ + + TD EPT AR +FPCFDEP KA ++I I + A
Sbjct: 173 GDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIA 232
Query: 256 LSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQ 315
LSNMP K ++ FE +V MSTYLV + V F S+ ++SG ++IY P++
Sbjct: 233 LSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDK 292
Query: 316 KHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYD 375
++ YA + + D++E+YF + Y L KLD IAIPDF GAMENWGLITYRET+LL+D
Sbjct: 293 RNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFD 352
Query: 376 PKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQ 435
PK S++S++ V V+AHEL HQWFGN+VTM+WW D+WL EGFA + E + VN + Q
Sbjct: 353 PKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQ 412
Query: 436 MRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKP 495
D L V DSL SS PI TP +I +FD +SY+KG+ IL ML+D++
Sbjct: 413 F-DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGE 471
Query: 496 ENFQKGCQMYLEKYQFKNAKTSDFWAALEEA---------------------------SR 528
E FQKG YL+K+ ++NAK D W++L +
Sbjct: 472 EKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGEN 531
Query: 529 LPVKEVMDTWTRQMGYPVLNV--NGVK-NITQKRFLLDP-RANPSQPPSDLGYTWNIPVK 584
VKE+M TWT Q G P+L V +G + Q+RFL + +P Y W+IP+
Sbjct: 532 AEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLT 591
Query: 585 WTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALS 644
+ + +SS + +R + T P +++K N D G+Y V+YE WD + T L+
Sbjct: 592 Y---STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLN 648
Query: 645 LNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIIS 704
NH DR LI D F L A L AL++T YL+ E + ++ ++Y+ S
Sbjct: 649 QNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLES 705
Query: 705 MF-----EDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDRE 759
+ + ++ ++ Y KP+ D W+D G ++LRS++L AC +
Sbjct: 706 FYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAP 765
Query: 760 ALNNASSLFEQWL--NGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKE 817
+ A+ LF QW+ +G +++P ++ +VY G Q + WNY LEQY+ + + E+
Sbjct: 766 CIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTA---GWNYLLEQYELSMSSAEQN 822
Query: 818 KLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDY 877
K+LY L++ K+ L + ++L + +IKTQ++ ++ I+ G+ +AW++++ NW +
Sbjct: 823 KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882
Query: 878 LVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNI 936
L+ ++ L + ++ I++ F+++ +L +++ FF G+ + VLET+ NI
Sbjct: 883 LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942
Query: 937 EWLKQHRNTIREW 949
+WL+++ T+R W
Sbjct: 943 KWLEKNLPTLRTW 955
>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 538 bits (1387), Expect = e-153
Identities = 311/913 (34%), Positives = 490/913 (53%), Gaps = 56/913 (6%)
Query: 80 ASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRET 139
A+ E W+ RLP V P+HYDL V P L + + I + +S T+++ LH ++
Sbjct: 56 ATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDL 115
Query: 140 RITRLPELKRPSGDQVQVRR---CFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWL 196
IT ++ + Y E + + E+LTP Y + M+F L
Sbjct: 116 EITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLK---YYVAMDFQAKL 172
Query: 197 NGSLVGFYRTTY-TENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGA 255
GFY++TY T G+ + + TD EPT AR +FPCFDEP KA ++I I + A
Sbjct: 173 GDGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIA 232
Query: 256 LSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQ 315
LSNMP K ++ FE +V MSTYLV + V F S+ ++SG ++IY P++
Sbjct: 233 LSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDK 292
Query: 316 KHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYD 375
++ YA + + D++E+YF + Y L KLD IAIPDF GAMENWGLITYRET+LL+D
Sbjct: 293 RNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFD 352
Query: 376 PKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQ 435
PK S++S++ V V+AHEL HQWFGN+VTM+WW D+WL EGFA + E + VN + Q
Sbjct: 353 PKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPELQ 412
Query: 436 MRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKP 495
D L V DSL SS PI TP +I +FD +SY+KG+ IL ML+D++
Sbjct: 413 F-DDYFLNVCFEVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGE 471
Query: 496 ENFQKGCQMYLEKYQFKNAKTSDFWAALEEA---------------------------SR 528
E FQKG YL+K+ ++NAK D W++L +
Sbjct: 472 EKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGEN 531
Query: 529 LPVKEVMDTWTRQMGYPVLNV--NGVK-NITQKRFLLDP-RANPSQPPSDLGYTWNIPVK 584
VKE+M TWT Q G P+L V +G + Q+RFL + +P Y W+IP+
Sbjct: 532 AEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLT 591
Query: 585 WTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALS 644
+ + +SS + +R + T P +++K N D G+Y V+YE WD + T L+
Sbjct: 592 Y---STSSSNVIHRHILKSKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLN 648
Query: 645 LNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIIS 704
NH DR LI D F L A L AL++T YL+ E + ++ ++Y+ S
Sbjct: 649 QNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PALLEGLSYLES 705
Query: 705 MF-----EDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDRE 759
+ + ++ ++ Y KP+ D W+D G ++LRS++L AC +
Sbjct: 706 FYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAP 765
Query: 760 ALNNASSLFEQWL--NGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKE 817
+ A+ LF QW+ +G +++P ++ +VY G Q + WNY LEQY+ + + E+
Sbjct: 766 CIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQTTA---GWNYLLEQYELSMSSAEQN 822
Query: 818 KLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDY 877
K+LY L++ K+ L + ++L + +IKTQ++ ++ I+ G+ +AW++++ NW +
Sbjct: 823 KILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTH 882
Query: 878 LVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNI 936
L+ ++ L + ++ I++ F+++ +L +++ FF G+ + VLET+ NI
Sbjct: 883 LLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTVLETITKNI 942
Query: 937 EWLKQHRNTIREW 949
+WL+++ T+R W
Sbjct: 943 KWLEKNLPTLRTW 955
>gi|94818891 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform b [Homo sapiens]
Length = 941
Score = 520 bits (1338), Expect = e-147
Identities = 308/937 (32%), Positives = 497/937 (53%), Gaps = 69/937 (7%)
Query: 53 TAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEE 112
T PS S+ ASP S+ W RLP++V PVHYDL + L
Sbjct: 25 TVSTPSWCQSTEASPK-----------RSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTT 73
Query: 113 DTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVR--RCFEYKKQEYVV 170
T+ GT + I S PT + LH +I+R L++ +G+++ + E+ +QE +
Sbjct: 74 LTFWGTTKVEITASQPTSTIILHSHHLQISRAT-LRKGAGERLSEEPLQVLEHPRQEQIA 132
Query: 171 VEAEEELTPSSGDGL-YLLTMEFAGWLNGSLVGFYRTTY-TENGQVKSIVATDHEPTDAR 228
+ A E L GL Y + + +AG L+ + GFY++TY T+ G+++ + +T EPT AR
Sbjct: 133 LLAPEPLLV----GLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAAR 188
Query: 229 KSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVC 288
+FPCFDEP KA+++I I + A+SNMP+ K +V + F+ +V MSTYLV
Sbjct: 189 MAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVA 248
Query: 289 FAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDK 348
F + F+SV +I+ SG +++Y P++ + A+YA + ++ +++E+YF++ Y LPK D
Sbjct: 249 FIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDL 308
Query: 349 IAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDW 408
AIPDF +GAMENWGL TYRE+ LL+D ++S++S++ + VAHEL HQWFGN+VTM+W
Sbjct: 309 AAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEW 368
Query: 409 WEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPD 468
W DLWLNEGFA F EF+ V+ + ++ D E D+L SSHP+ V P
Sbjct: 369 WNDLWLNEGFAKFMEFVSVSVTHPELKVGD-YFFGKCFDAMEVDALNSSHPVSTPVENPA 427
Query: 469 EITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEE--- 525
+I +FD +SY KG+ IL ML +++ + F+ G YL+K+ +KN K D W ++
Sbjct: 428 QIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICP 487
Query: 526 ----------ASR--------------LPVKEVMDTWTRQMGYPVLNVN-GVKNITQKRF 560
SR + VK +M+TWT Q G+P++ + +N+ K+
Sbjct: 488 TDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQ- 546
Query: 561 LLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKIN 620
+ S D GY W++P+ + F K + + P ++K N
Sbjct: 547 --EHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLI---LPEEVEWIKFN 601
Query: 621 PDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLT 680
G+Y V+YE WDS+ L H SS DRASLI++AF L L + AL+L+
Sbjct: 602 VGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLS 661
Query: 681 KYLKREENFLPWQRVISAVTYIISMFE-----DDKELYPMIEEYFQGQVKPIADSLGWND 735
YLK E +P V + +I M++ D E+ + + ++ + D W D
Sbjct: 662 LYLKHETEIMP---VFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTD 718
Query: 736 AGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQW--LNGTVSLPVNLRLLVYRYGMQN 793
G ++LRS +L AC + + A F +W NG +SLPV++ L V+ G Q+
Sbjct: 719 EGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQS 778
Query: 794 SGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTV 853
+ W++ +YQ + + EK ++ + L +N L LD + IKTQ+ +
Sbjct: 779 TE---GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQI 835
Query: 854 IRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFF 912
+ I N G +AW +++ NW+ LV ++ L + ++ +V F+T +L +++ FF
Sbjct: 836 LTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFF 895
Query: 913 AKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
+ + G+ + +Q +ET++ NI W+ ++ + IR W
Sbjct: 896 SSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVW 932
>gi|94818901 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform a [Homo sapiens]
Length = 948
Score = 520 bits (1338), Expect = e-147
Identities = 308/937 (32%), Positives = 497/937 (53%), Gaps = 69/937 (7%)
Query: 53 TAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEE 112
T PS S+ ASP S+ W RLP++V PVHYDL + L
Sbjct: 25 TVSTPSWCQSTEASPK-----------RSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTT 73
Query: 113 DTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVR--RCFEYKKQEYVV 170
T+ GT + I S PT + LH +I+R L++ +G+++ + E+ +QE +
Sbjct: 74 LTFWGTTKVEITASQPTSTIILHSHHLQISRAT-LRKGAGERLSEEPLQVLEHPRQEQIA 132
Query: 171 VEAEEELTPSSGDGL-YLLTMEFAGWLNGSLVGFYRTTY-TENGQVKSIVATDHEPTDAR 228
+ A E L GL Y + + +AG L+ + GFY++TY T+ G+++ + +T EPT AR
Sbjct: 133 LLAPEPLLV----GLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAAR 188
Query: 229 KSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVC 288
+FPCFDEP KA+++I I + A+SNMP+ K +V + F+ +V MSTYLV
Sbjct: 189 MAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVA 248
Query: 289 FAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDK 348
F + F+SV +I+ SG +++Y P++ + A+YA + ++ +++E+YF++ Y LPK D
Sbjct: 249 FIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDL 308
Query: 349 IAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDW 408
AIPDF +GAMENWGL TYRE+ LL+D ++S++S++ + VAHEL HQWFGN+VTM+W
Sbjct: 309 AAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEW 368
Query: 409 WEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPD 468
W DLWLNEGFA F EF+ V+ + ++ D E D+L SSHP+ V P
Sbjct: 369 WNDLWLNEGFAKFMEFVSVSVTHPELKVGD-YFFGKCFDAMEVDALNSSHPVSTPVENPA 427
Query: 469 EITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEE--- 525
+I +FD +SY KG+ IL ML +++ + F+ G YL+K+ +KN K D W ++
Sbjct: 428 QIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICP 487
Query: 526 ----------ASR--------------LPVKEVMDTWTRQMGYPVLNVN-GVKNITQKRF 560
SR + VK +M+TWT Q G+P++ + +N+ K+
Sbjct: 488 TDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQ- 546
Query: 561 LLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKIN 620
+ S D GY W++P+ + F K + + P ++K N
Sbjct: 547 --EHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLI---LPEEVEWIKFN 601
Query: 621 PDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLT 680
G+Y V+YE WDS+ L H SS DRASLI++AF L L + AL+L+
Sbjct: 602 VGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLS 661
Query: 681 KYLKREENFLPWQRVISAVTYIISMFE-----DDKELYPMIEEYFQGQVKPIADSLGWND 735
YLK E +P V + +I M++ D E+ + + ++ + D W D
Sbjct: 662 LYLKHETEIMP---VFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTD 718
Query: 736 AGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQW--LNGTVSLPVNLRLLVYRYGMQN 793
G ++LRS +L AC + + A F +W NG +SLPV++ L V+ G Q+
Sbjct: 719 EGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQS 778
Query: 794 SGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTV 853
+ W++ +YQ + + EK ++ + L +N L LD + IKTQ+ +
Sbjct: 779 TE---GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQI 835
Query: 854 IRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IAEPFNTELQLWQMESFF 912
+ I N G +AW +++ NW+ LV ++ L + ++ +V F+T +L +++ FF
Sbjct: 836 LTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFF 895
Query: 913 AKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
+ + G+ + +Q +ET++ NI W+ ++ + IR W
Sbjct: 896 SSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVW 932
>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
Length = 1024
Score = 504 bits (1297), Expect = e-142
Identities = 329/1004 (32%), Positives = 508/1004 (50%), Gaps = 79/1004 (7%)
Query: 9 SKRYCIQTKHVAILCAV-VVGVGLIVGLAVGLTRSCDSSG-------DGGPGTAP---AP 57
++R+ K + + AV +V + + LAV L+ D G DGGP P
Sbjct: 30 TERHIAVHKRLVLAFAVSLVALLAVTMLAVLLSLRFDECGASATPGADGGPSGFPERGGN 89
Query: 58 SHLPSST------------------ASPSGPPAQDQDICPASEDESGQWK---NFRLPDF 96
LP S ASP AQ P SE+E W+ RL
Sbjct: 90 GSLPGSARRNHHAGGDSWQPEAGGVASPGTTSAQ-----PPSEEEREPWEPWTQLRLSGH 144
Query: 97 VNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQ 156
+ P+HY+L + +E T++G V++ I TRY+ LH + ++ + + V
Sbjct: 145 LKPLHYNLMLTAFMENFTFSGEVNVEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVP 204
Query: 157 VRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKS 216
V F Y + + +VV L Y L + + + L+GF+R++Y +G+ +
Sbjct: 205 VAGFFLYPQTQVLVVVLNRTLDAQRN---YNLKIIYNALIENELLGFFRSSYVLHGERRF 261
Query: 217 IVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTF 276
+ T PT ARK+FPCFDEP KAT+ ISI H Y +LSNMPV +D W F
Sbjct: 262 LGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVETSVFEEDGWVTDHF 321
Query: 277 EKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPE--QKHTAEYAANITKSVFDYFE 334
++ MSTY + +A+ F + + SG + +Y +P+ ++ + +YA +ITK + +++E
Sbjct: 322 SQTPLMSTYYLAWAICNFTYRETTTKSGVVVRLYARPDAIRRGSGDYALHITKRLIEFYE 381
Query: 335 EYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHE 394
+YF + YSLPKLD +A+P AMENWGL + E +L DP S+ S V V+ HE
Sbjct: 382 DYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHE 441
Query: 395 LVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVL-PVQEDDS 453
+ HQWFG++VT WWED+WL EGFA +FEF+G ++ W M Q L DVL V D
Sbjct: 442 ICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDG 501
Query: 454 LMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKN 513
L SSHP+ V +I VFD I+Y KG++++RML +++ FQ+G Q YL +++ N
Sbjct: 502 LASSHPVSQEVLQATDIDRVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYGN 561
Query: 514 AKTSDFWAALEEASR-----LPVKEVMDTWTRQMGYPVLNVNGVKN------ITQKRFLL 562
A +D W L EA + + ++EVMD WT QMGYPV+ + G ITQ+ F+
Sbjct: 562 AARNDLWNTLSEALKRNGKYVNIQEVMDQWTLQMGYPVITILGNTTAENRIIITQQHFIY 621
Query: 563 DPRA-NPSQPPSDLGYTWNIP---VKWTEDNITSSVLF---NRSEKEGITLNSSNPSGNA 615
D A + + Y W IP V +++S + N+SE IT +
Sbjct: 622 DISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSEAIIWVSNKSEHHRITYLDK----GS 677
Query: 616 FLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKV 675
+L N + G++RVNY++ W + L NH+ S ++RA LIDDAF+LARA L +
Sbjct: 678 WLLGNINQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNI 737
Query: 676 ALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGW-- 733
L + +YL E++FLPW S Y + D E Y + EY QV LGW
Sbjct: 738 PLEIIRYLSEEKDFLPW-HAASRALYPLDKLLDRMENYNIFNEYILKQVATTYIKLGWPK 796
Query: 734 -NDAGDHVT-----KLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVS-LPVNLRLLV 786
N G V + LR V+ AC G++ AS+L W++ + +P+N+R +V
Sbjct: 797 NNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIV 856
Query: 787 YRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIK 846
Y G+ ++ W + ++ T+ EK+ LL L + LL+R L+L ++ ++
Sbjct: 857 YCTGVSLLDEDV-WEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVL 915
Query: 847 TQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRY-TLNNRNLGRIVTIAEPFNTELQL 905
QD VI +++ N +G+++AW + + W L RY N I + E NTE +L
Sbjct: 916 DQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGEALFMNSKLISGVTEFLNTEGEL 975
Query: 906 WQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
++++F Y A R +ETV+ N+ W +++ + +W
Sbjct: 976 KELKNFMKNYDGVAAASFSR--AVETVEANVRWKMLYQDELFQW 1017
>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
Length = 919
Score = 482 bits (1241), Expect = e-136
Identities = 299/874 (34%), Positives = 469/874 (53%), Gaps = 34/874 (3%)
Query: 92 RLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPS 151
RLP V+P++Y L +KP L + T+ G + + + T + ++ + I + P
Sbjct: 53 RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDI--ITASYAPE 110
Query: 152 GDQVQVRRCFEYKKQ-EYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210
GD+ F Y+ + E V + L +G L ++F G LN + GFYR+ YT
Sbjct: 111 GDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGT----LKIDFVGELNDKMKGFYRSKYTT 166
Query: 211 -NGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESV-- 267
+G+V+ T E TDAR++FPC+DEP KAT+ IS+ PK+ ALSNM V +
Sbjct: 167 PSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPD 226
Query: 268 DDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITK 327
D+ F ++ MSTYLV F V ++D V+ S G + +Y + ++A +
Sbjct: 227 DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAA 286
Query: 328 SVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRV 387
++++YF + Y LPK+D IAI DF GAMENWGL+TYRET LL DPK S SS++Q V
Sbjct: 287 KTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWV 346
Query: 388 ATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLP 447
A VV HEL HQWFGN+VTM+WW LWLNEGFAS+ E+L V+H ++ + Q + D
Sbjct: 347 ALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTR 406
Query: 448 VQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLE 507
QE D+L +SHPI V+V P E+ +FD ISYSKG+S++RML D+I ++F+KG MYL
Sbjct: 407 AQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLT 466
Query: 508 KYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNG-------VKNITQKRF 560
K+Q KNA T D W +LE AS P+ VM+TWT+QMG+P++ V + ++QK+F
Sbjct: 467 KFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKF 526
Query: 561 LLDPRANPSQPPSDLGYTWNIPVK-WTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKI 619
A S D W +P+ T ++ + L +K + + N + ++K+
Sbjct: 527 C----AGGSYVGEDCP-QWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKL 581
Query: 620 NPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNL 679
N +GFYR Y A +S+ + + DR L +D F+LARA ++ L +
Sbjct: 582 NLGTVGFYRTQYSSAMLESLLP--GIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKV 639
Query: 680 TKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWN--DAG 737
+ E N+ W +S I+S + Y I+E+ + PI + LGW+
Sbjct: 640 MEAFVNEPNYTVWSD-LSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGE 698
Query: 738 DHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNE 797
H+ LLR VLG K G + L A F+ + G L +LR VY +++ G+
Sbjct: 699 GHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKH-GDG 757
Query: 798 ISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYI 857
+ + L+ +++ + +EK ++ L + L+ + L ++ QD +VI +
Sbjct: 758 TTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEE-VRPQDTVSVIGGV 816
Query: 858 SYNS-YGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIA-EPFNTELQLWQMESFFAKY 915
+ S +G+ AW +I+ NW+ L NRY + R++ ++ E F + ++++FF +
Sbjct: 817 AGGSKHGRKAAWKFIKDNWEELYNRYQ-GGFLISRLIKLSVEGFAVDKMAGEVKAFFESH 875
Query: 916 PQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
P A + E+ +Q E + N WLK+ +I ++
Sbjct: 876 P-APSAERTIQQCCENILLNAAWLKRDAESIHQY 908
>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
Length = 1025
Score = 477 bits (1227), Expect = e-134
Identities = 299/953 (31%), Positives = 485/953 (50%), Gaps = 50/953 (5%)
Query: 14 IQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQ 73
+ + ++CA V+ V + V + + L C + +G H + + P A
Sbjct: 105 VPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEG--------CHKKNQSIGLIQPFAT 156
Query: 74 DQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLW 133
+ + P W RLP V P+ Y+L + P L T+ G+V+IS+ T +
Sbjct: 157 NGKLFP--------WAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNII 208
Query: 134 LHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFA 193
LH I+R+ + S + Q EY + + A E L Y L +E++
Sbjct: 209 LHSTGHNISRVTFMSAVSSQEKQAE-ILEYAYHGQIAIVAPEALLAGHN---YTLKIEYS 264
Query: 194 GWLNGSLVGFYRTTYT-ENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKE 252
++ S GFY +YT E+ + K AT EP AR +FPCFDEP KAT+ I I ++
Sbjct: 265 ANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQ 324
Query: 253 YGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQ 312
Y ALSNMP +DD + F +SV MSTYLV F V + ++ + N G ++IY
Sbjct: 325 YTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAV 383
Query: 313 PEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNL 372
PE+ YA T + ++F+ YF + Y L KLD +AIPDF GAMENWGL+T+RE L
Sbjct: 384 PEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETL 443
Query: 373 LYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAET 432
LYD S+ ++++ V ++AHEL HQWFGN+VTM WW DLWLNEGFA+F E+ +
Sbjct: 444 LYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK 503
Query: 433 DWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDW 492
+ + L+ + DSL SSHPI +V + ++I +FD +SY KGSS+L ML+ +
Sbjct: 504 ELSSYED-FLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTY 562
Query: 493 IKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASR--LPVKEVMDTWTRQMGYPVLNVN 550
+ + FQ +YL + + + ++ D W + E + L VK +M TWT Q G+P++ V
Sbjct: 563 LSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQ 622
Query: 551 GVKN---ITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTED--NITSSVLFNRSEKEGIT 605
I Q+RF L+ + P PSD Y W+IP+ + + N + + +K+
Sbjct: 623 KKGKELFIQQERFFLNMK--PEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGV 680
Query: 606 LNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFAL 665
+N + ++K+N + G+Y V+Y W+++ L +N S DRA+LI++ F L
Sbjct: 681 INLTEEV--LWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFEL 738
Query: 666 ARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFED------DKELYPMIEEY 719
A + K A +L YL E + P + I ++ E L + +
Sbjct: 739 AGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKL 798
Query: 720 FQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWL--NGTVS 777
Q Q++ W D G + LRS++L FAC A LF+ W+ NGT S
Sbjct: 799 LQNQIQ----QQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQS 854
Query: 778 LPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLD 837
LP ++ V++ G + + W++ L +Y EK K+L LAS ++V L +
Sbjct: 855 LPTDVMTTVFKVGAK---TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMK 911
Query: 838 LLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IA 896
+ + +TQ + +IR + + G +AW++++ NW+ LV ++ L + + IV
Sbjct: 912 SSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGST 971
Query: 897 EPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
F+T+ L ++++FF +A + ++ LE ++ NI+W++++ ++ W
Sbjct: 972 YLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWW 1024
>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
Length = 1011
Score = 477 bits (1227), Expect = e-134
Identities = 299/953 (31%), Positives = 485/953 (50%), Gaps = 50/953 (5%)
Query: 14 IQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQ 73
+ + ++CA V+ V + V + + L C + +G H + + P A
Sbjct: 91 VPSARTMVVCAFVIVVAVSVIMVIYLLPRCTFTKEG--------CHKKNQSIGLIQPFAT 142
Query: 74 DQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLW 133
+ + P W RLP V P+ Y+L + P L T+ G+V+IS+ T +
Sbjct: 143 NGKLFP--------WAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNII 194
Query: 134 LHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFA 193
LH I+R+ + S + Q EY + + A E L Y L +E++
Sbjct: 195 LHSTGHNISRVTFMSAVSSQEKQAE-ILEYAYHGQIAIVAPEALLAGHN---YTLKIEYS 250
Query: 194 GWLNGSLVGFYRTTYT-ENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKE 252
++ S GFY +YT E+ + K AT EP AR +FPCFDEP KAT+ I I ++
Sbjct: 251 ANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRDEQ 310
Query: 253 YGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQ 312
Y ALSNMP +DD + F +SV MSTYLV F V + ++ + N G ++IY
Sbjct: 311 YTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVN-GTLVSIYAV 369
Query: 313 PEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNL 372
PE+ YA T + ++F+ YF + Y L KLD +AIPDF GAMENWGL+T+RE L
Sbjct: 370 PEKIGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETL 429
Query: 373 LYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAET 432
LYD S+ ++++ V ++AHEL HQWFGN+VTM WW DLWLNEGFA+F E+ +
Sbjct: 430 LYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFK 489
Query: 433 DWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDW 492
+ + L+ + DSL SSHPI +V + ++I +FD +SY KGSS+L ML+ +
Sbjct: 490 ELSSYED-FLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTY 548
Query: 493 IKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASR--LPVKEVMDTWTRQMGYPVLNVN 550
+ + FQ +YL + + + ++ D W + E + L VK +M TWT Q G+P++ V
Sbjct: 549 LSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQKGFPLVTVQ 608
Query: 551 GVKN---ITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTED--NITSSVLFNRSEKEGIT 605
I Q+RF L+ + P PSD Y W+IP+ + + N + + +K+
Sbjct: 609 KKGKELFIQQERFFLNMK--PEIQPSDTSYLWHIPLSYVTEGRNYSKYQSVSLLDKKSGV 666
Query: 606 LNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFAL 665
+N + ++K+N + G+Y V+Y W+++ L +N S DRA+LI++ F L
Sbjct: 667 INLTEEV--LWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFEL 724
Query: 666 ARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFED------DKELYPMIEEY 719
A + K A +L YL E + P + I ++ E L + +
Sbjct: 725 AGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRLVTRVFKL 784
Query: 720 FQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWL--NGTVS 777
Q Q++ W D G + LRS++L FAC A LF+ W+ NGT S
Sbjct: 785 LQNQIQ----QQTWTDEGTPSMRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQS 840
Query: 778 LPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLD 837
LP ++ V++ G + + W++ L +Y EK K+L LAS ++V L +
Sbjct: 841 LPTDVMTTVFKVGAK---TDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMK 897
Query: 838 LLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVT-IA 896
+ + +TQ + +IR + + G +AW++++ NW+ LV ++ L + + IV
Sbjct: 898 SSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGST 957
Query: 897 EPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREW 949
F+T+ L ++++FF +A + ++ LE ++ NI+W++++ ++ W
Sbjct: 958 YLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWW 1010
>gi|194239713 laeverin [Homo sapiens]
Length = 990
Score = 431 bits (1107), Expect = e-120
Identities = 280/932 (30%), Positives = 478/932 (51%), Gaps = 69/932 (7%)
Query: 53 TAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEE 112
++P P+ T PS P++ G W RLP ++ P+HYDL + P L
Sbjct: 58 SSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRP 117
Query: 113 DT-------YTGTVSISINLSAPTRYLWLHL-------RETRITRLPELKRPSGDQVQVR 158
D +TG V+I++ + T L LH E R P + +V V
Sbjct: 118 DELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVD 177
Query: 159 RCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSL-VGFYRTTYTENGQVKSI 217
+ EY+V+E E L P S Y L + F+G + L G + YT+ G+ +++
Sbjct: 178 DVWFALDTEYMVLELSEPLKPGSS---YELQLSFSGLVKEDLREGLFLNVYTDQGERRAL 234
Query: 218 VATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDD----KWTR 273
+A+ EPT AR FPCFDEP KAT+ I++ H Y ALSNMP + +D KWT
Sbjct: 235 LASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTV 294
Query: 274 TTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQ--KHTAEYAANITKSVFD 331
TTF + M TYLV F + +D V R + GK + I+ + + +A++A NIT +F
Sbjct: 295 TTFSTTPHMPTYLVAFVICDYDHVNR-TERGKEIRIWARKDAIANGSADFALNITGPIFS 353
Query: 332 YFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVV 391
+ E+ F ++YSLPK D IA+P F AMENWGL+ + E+ LL +PK+ + + ++ VV
Sbjct: 354 FLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVV 413
Query: 392 AHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVL-PVQE 450
+HE+ HQWFGN+VTM+WW ++WLNEGFAS+FEF +N+ R+++ ++L +
Sbjct: 414 SHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLP-RNEIFFSNILHNILR 472
Query: 451 DDSLMSSHPIIVTVTT--PDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEK 508
+D + + + + V EI +FD +YSKG+S+ RML ++ F + YL+
Sbjct: 473 EDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKT 532
Query: 509 YQFKNAKTSDFW----AALEEASRL----PVKEVMDTWTRQMGYPVLNVNGVKNI-TQKR 559
+ + NA+ D W A+++ S + +K +MD+WT Q G+PV+ +N + Q+
Sbjct: 533 FSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEP 592
Query: 560 FLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKI 619
F L+ N + S+ TW +P+ W ++ T +++ + + S + ++ +
Sbjct: 593 FYLENIKNRTLLTSN--DTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVIL 650
Query: 620 NPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNL 679
N + G+YRVNY+ W + L + K R LIDDAF+L++ ++ + AL L
Sbjct: 651 NLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALEL 710
Query: 680 TKYLKREENFLPWQRV-ISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWND--- 735
TKYL E+ + W V ++ VT + + ++Y +++ Y ++ +L WN
Sbjct: 711 TKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRL-----NLIWNIYST 765
Query: 736 ---------AGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVS-LPVNLRLL 785
D++ + + AC +G + L + LF +W++ + +P ++ +
Sbjct: 766 IIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDV 825
Query: 786 VYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLI 845
V YG+ G++ W+ L Y T+ +EK +L Y ++ K+ +L+RY++ T+
Sbjct: 826 VLCYGIA-LGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPF 884
Query: 846 KTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQL 905
T + +I ++ + G+ +A +++ NW + RY + + I TI T+LQ+
Sbjct: 885 -TSNETNIIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSL-INLIYTIGRTVTTDLQI 942
Query: 906 WQMESFFAKYPQAGAGEKPREQV---LETVKN 934
+++ FF+ + E R +V L+T+KN
Sbjct: 943 VELQQFFSNMLE----EHQRIRVHANLQTIKN 970
>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
Length = 611
Score = 93.2 bits (230), Expect = 1e-18
Identities = 115/478 (24%), Positives = 191/478 (39%), Gaps = 62/478 (12%)
Query: 114 TYTGTVSISINLSAPT-RYLWLHLRETRITR-----------LPELKRPSGDQVQVRRCF 161
T TGT ++++ R L L ++ I + L E + G +++
Sbjct: 34 TLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPI 93
Query: 162 EYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATD 221
K + +V+E E +P S L LT E +G+ + +
Sbjct: 94 ALSKNQEIVIEISFETSPKSS-ALQWLTPE-----------------QTSGKEHPYLFSQ 135
Query: 222 HEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFE--KS 279
+ R PC D P+ K TYT ++ PKE AL + E + +R ++ +
Sbjct: 136 CQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQK 195
Query: 280 VPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAM 339
VP+ YL+ V +S G ++ + EQ + Y + T+S+ E+
Sbjct: 196 VPIPCYLIALVVGALES----RQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAED-LGG 250
Query: 340 NYSLPKLDKIAIP-DFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQ 398
Y + D + +P F G MEN +T+ LL K ++ V+AHE+ H
Sbjct: 251 PYVWGQYDLLVLPPSFPYGGMEN-PCLTFVTPTLLAGDKS--------LSNVIAHEISHS 301
Query: 399 WFGNIVTMDWWEDLWLNEGFASFFE--FLGVNHAETDWQMRDQMLLEDVLPVQED-DSLM 455
W GN+VT W+ WLNEG + E G E + R L +Q +
Sbjct: 302 WTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGE---KFRHFNALGGWGELQNSVKTFG 358
Query: 456 SSHP---IIVTVTTPDEITSVFDGISYSKGSSILRMLEDWI-KPENFQKGCQMYLEKYQF 511
+HP ++V +T D + + + Y KG ++L LE + PE F + Y+EK+ +
Sbjct: 359 ETHPFTKLVVDLTDIDPDVA-YSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSY 417
Query: 512 KNAKTSDFWAALEE--ASRLPVKEVMD--TWTRQMGYPVLNVNGVKNITQKRFLLDPR 565
K+ T D+ L ++ V +D W G P + N +T L R
Sbjct: 418 KSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQR 475
>gi|40316915 arginyl aminopeptidase [Homo sapiens]
Length = 650
Score = 75.9 bits (185), Expect = 2e-13
Identities = 82/350 (23%), Positives = 137/350 (39%), Gaps = 36/350 (10%)
Query: 212 GQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKW 271
G+ K V T + R FPCFD P K Y+ I P + A+ + ++ +
Sbjct: 160 GKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPN--- 216
Query: 272 TRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFD 331
+ F+ P+ +YL+ A+ S + G ++ +P A+ N F
Sbjct: 217 -KFFFQMCQPIPSYLIALAIGDLVSAE----VGPRSRVWAEPCLIDAAKEEYNGVIEEFL 271
Query: 332 YFEEYFAMNYSLPKLDKIAIP-DFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATV 390
E Y + D + +P F G MEN +T+ LL + + +A V
Sbjct: 272 ATGEKLFGPYVWGRYDLLFMPPSFPFGGMEN-PCLTFVTPCLL--------AGDRSLADV 322
Query: 391 VAHELVHQWFGNIVTMDWWEDLWLNEGFASFFE------FLGVNHAETDWQMRDQMLLED 444
+ HE+ H WFGN+VT W + WLNEGF + + G + + +L +
Sbjct: 323 IIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQH 382
Query: 445 VLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWI-KPENFQKGCQ 503
+ E++ L I PD+ ++ Y KG + L + + F +
Sbjct: 383 MDITGEENPLNKLRVKIEPGVDPDD---TYNETPYEKGFCFVSYLAHLVGDQDQFDSFLK 439
Query: 504 MYLEKYQFKNAKTSDFW-AALEEASRLPVKEV-------MDTWTRQMGYP 545
Y+ +++F++ DF LE L K V D W G+P
Sbjct: 440 AYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWP 489
>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
sapiens]
Length = 494
Score = 57.8 bits (138), Expect = 5e-08
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 352 PDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWED 411
P F AMEN +T+ +++L + + + V HE+ H WFGN VT WE+
Sbjct: 90 PSFPIVAMEN-PCLTFIISSIL--------ESDEFLVIDVIHEVAHSWFGNAVTNATWEE 140
Query: 412 LWLNEGFASF------FEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVT 465
+WL+EG A++ E G + R L + + ED + +
Sbjct: 141 MWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGEDSPVSKLQVKLEPGV 200
Query: 466 TPDEITSVFDGISYSKGSSILRMLEDWI-KPENFQKGCQMYLEKYQFKNAKTSD 518
P + ++F +Y KG + L P+ F + Y+EKY+F + D
Sbjct: 201 NPSHLMNLF---TYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVAQD 251
>gi|4507347 TBP-associated factor 2 [Homo sapiens]
Length = 1199
Score = 41.6 bits (96), Expect = 0.004
Identities = 37/192 (19%), Positives = 78/192 (40%), Gaps = 6/192 (3%)
Query: 231 FPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTT-FEKSVPMSTYLVCF 289
FPC D ++ T+ + T A+SN + + D +T + ++P + +
Sbjct: 190 FPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTIPTAASNISL 249
Query: 290 AVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKI 349
A+ F+ + + +T + P+ ++ + VF+++EE Y +
Sbjct: 250 AIGPFEIL--VDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTV 307
Query: 350 AIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWW 409
I D + + ++ TNLL+ + R +A L Q+FG ++ W
Sbjct: 308 FI-DEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTR--RCLAQSLAQQFFGCFISRMSW 364
Query: 410 EDLWLNEGFASF 421
D W+ +G + +
Sbjct: 365 SDEWVLKGISGY 376
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 34.7 bits (78), Expect = 0.44
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 12/92 (13%)
Query: 134 LHLRETRIT----RLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLT 189
LH R +++ R ++ S +Q+ VR F +++ E+EL+ S GD +++
Sbjct: 112 LHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTN------EDELSFSKGDVIHVTR 165
Query: 190 MEFAGWLNGSLVGFYRTTYTENGQVKSIVATD 221
+E GW G+L G RT + + V+ + A++
Sbjct: 166 VEEGGWWEGTLNG--RTGWFPSNYVREVKASE 195
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 34.7 bits (78), Expect = 0.44
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 12/92 (13%)
Query: 134 LHLRETRIT----RLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLT 189
LH R +++ R ++ S +Q+ VR F +++ E+EL+ S GD +++
Sbjct: 162 LHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTN------EDELSFSKGDVIHVTR 215
Query: 190 MEFAGWLNGSLVGFYRTTYTENGQVKSIVATD 221
+E GW G+L G RT + + V+ + A++
Sbjct: 216 VEEGGWWEGTLNG--RTGWFPSNYVREVKASE 245
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 34.7 bits (78), Expect = 0.44
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 12/92 (13%)
Query: 134 LHLRETRIT----RLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLT 189
LH R +++ R ++ S +Q+ VR F +++ E+EL+ S GD +++
Sbjct: 141 LHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTN------EDELSFSKGDVIHVTR 194
Query: 190 MEFAGWLNGSLVGFYRTTYTENGQVKSIVATD 221
+E GW G+L G RT + + V+ + A++
Sbjct: 195 VEEGGWWEGTLNG--RTGWFPSNYVREVKASE 224
>gi|133922582 zinc finger protein 358 [Homo sapiens]
Length = 568
Score = 34.7 bits (78), Expect = 0.44
Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 4/53 (7%)
Query: 26 VVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSH--LPSSTASPSGPPAQDQD 76
V+G GL GL+ G + + GPGT P PS LP S ++PS P + D
Sbjct: 445 VLGSGL--GLSPGTSSGRNPDPGSGPGTLPDPSSKPLPGSRSTPSPTPVESSD 495
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 33.9 bits (76), Expect = 0.75
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 8/71 (11%)
Query: 151 SGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210
S +Q+ VR F +++ E+EL+ S GD +++ +E GW G+L G RT +
Sbjct: 5 SNNQLVVRAKFNFQQTN------EDELSFSKGDVIHVTRVEEGGWWEGTLNG--RTGWFP 56
Query: 211 NGQVKSIVATD 221
+ V+ + A++
Sbjct: 57 SNYVREVKASE 67
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 33.9 bits (76), Expect = 0.75
Identities = 21/71 (29%), Positives = 39/71 (54%), Gaps = 8/71 (11%)
Query: 151 SGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTE 210
S +Q+ VR F +++ E+EL+ S GD +++ +E GW G+L G RT +
Sbjct: 5 SNNQLVVRAKFNFQQTN------EDELSFSKGDVIHVTRVEEGGWWEGTLNG--RTGWFP 56
Query: 211 NGQVKSIVATD 221
+ V+ + A++
Sbjct: 57 SNYVREVKASE 67
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 33.5 bits (75), Expect = 0.98
Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 8/82 (9%)
Query: 140 RITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGS 199
R ++ E+ Q+ V+ F +K+ E+EL+ GD +Y+ +E GW G+
Sbjct: 148 RQSKTVEMTENGSHQLIVKARFNFKQTN------EDELSVCKGDIIYVTRVEEGGWWEGT 201
Query: 200 LVGFYRTTYTENGQVKSIVATD 221
L G RT + + V+ I +++
Sbjct: 202 LNG--RTGWFPSNYVREIKSSE 221
>gi|148747351 protein kinase C and casein kinase substrate in
neurons 2 [Homo sapiens]
Length = 486
Score = 32.3 bits (72), Expect = 2.2
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 11/65 (16%)
Query: 151 SGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTME-FAGWLNGSL----VGFYR 205
SG +V+VR ++Y+ QE+ +EL+ +GD L + E GW G L VG Y
Sbjct: 425 SGTEVRVRALYDYEGQEH------DELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYP 478
Query: 206 TTYTE 210
Y E
Sbjct: 479 ANYVE 483
>gi|26051231 lactamase, beta isoform a [Homo sapiens]
Length = 547
Score = 32.3 bits (72), Expect = 2.2
Identities = 23/57 (40%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 26 VVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL-PSSTASPSGPPAQDQDICPAS 81
V G+GL +GLA+G+ + G G APA S P ASP P Q+Q + P S
Sbjct: 41 VGGLGLGLGLALGVKLA-----GGLRGAAPAQSPAAPDPEASPLAEPPQEQSLAPWS 92
>gi|26051233 lactamase, beta isoform b [Homo sapiens]
Length = 373
Score = 32.3 bits (72), Expect = 2.2
Identities = 23/57 (40%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 26 VVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHL-PSSTASPSGPPAQDQDICPAS 81
V G+GL +GLA+G+ + G G APA S P ASP P Q+Q + P S
Sbjct: 41 VGGLGLGLGLALGVKLA-----GGLRGAAPAQSPAAPDPEASPLAEPPQEQSLAPWS 92
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 32.0 bits (71), Expect = 2.8
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 6/41 (14%)
Query: 46 SGDGGPGTAPAPSHLPS------STASPSGPPAQDQDICPA 80
+GDGGP PAPS S S++SPS PP PA
Sbjct: 179 TGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPA 219
>gi|31711992 dihydrolipoamide S-acetyltransferase [Homo sapiens]
Length = 647
Score = 32.0 bits (71), Expect = 2.8
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 2/58 (3%)
Query: 16 TKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQ 73
T+ V I + + VG + + DSS P APAP+ P++TASP P AQ
Sbjct: 154 TRDVPIGAIICITVGKPEDIEAFKNYTLDSSAAPTPQAAPAPT--PAATASPPTPSAQ 209
>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
Length = 688
Score = 32.0 bits (71), Expect = 2.8
Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 2/51 (3%)
Query: 768 FEQWLN--GTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEK 816
F +LN G +S P LRL +Y G++ S ++ W Y L Y +E+
Sbjct: 204 FHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRER 254
>gi|239757409 PREDICTED: similar to zinc finger protein 208 [Homo
sapiens]
Length = 1059
Score = 31.6 bits (70), Expect = 3.7
Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 47 GDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFR 92
G G P AP P LP+ + +P GPPA C ++D+ G ++ +
Sbjct: 176 GLGAPAGAPGP--LPAPSQTPPGPPA--AAACDPTKDDKGYFRRLK 217
>gi|239746371 PREDICTED: similar to zinc finger protein 208 [Homo
sapiens]
Length = 1059
Score = 31.6 bits (70), Expect = 3.7
Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 47 GDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFR 92
G G P AP P LP+ + +P GPPA C ++D+ G ++ +
Sbjct: 176 GLGAPAGAPGP--LPAPSQTPPGPPA--AAACDPTKDDKGYFRRLK 217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,139,329
Number of Sequences: 37866
Number of extensions: 1753245
Number of successful extensions: 7029
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 6864
Number of HSP's gapped (non-prelim): 73
length of query: 957
length of database: 18,247,518
effective HSP length: 112
effective length of query: 845
effective length of database: 14,006,526
effective search space: 11835514470
effective search space used: 11835514470
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.