Search of human proteins with 47717131

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47717131 caspase recruitment domain protein 9 isoform 1
[Homo sapiens]
         (536 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo...  1053   0.0  
gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo...   942   0.0  
gi|157743265 caspase recruitment domain family, member 11 [Homo ...   370   e-102
gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]      285   1e-76
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom...   180   3e-45
gi|16507955 caspase recruitment domain protein 14 isoform 2 [Hom...    79   1e-14
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    74   3e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    72   1e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    72   1e-12
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    68   2e-11
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi...    68   2e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         67   4e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        67   4e-11
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        67   4e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         67   4e-11
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         67   4e-11
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         67   4e-11
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         67   4e-11
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         67   4e-11
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         67   4e-11
gi|148746195 trichohyalin [Homo sapiens]                               67   5e-11
gi|237858621 polyamine modulated factor 1 binding protein 1 isof...    65   1e-10
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...    65   1e-10
gi|31982906 cingulin-like 1 [Homo sapiens]                             65   1e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     65   2e-10
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    65   2e-10
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    65   2e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    64   3e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    64   3e-10
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    64   5e-10

>gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo
           sapiens]
          Length = 536

 Score = 1053 bits (2724), Expect = 0.0
 Identities = 536/536 (100%), Positives = 536/536 (100%)

Query: 1   MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRK 60
           MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRK
Sbjct: 1   MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRK 60

Query: 61  VGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLM 120
           VGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLM
Sbjct: 61  VGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLM 120

Query: 121 TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE 180
           TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE
Sbjct: 121 TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE 180

Query: 181 ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ 240
           ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ
Sbjct: 181 ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ 240

Query: 241 RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT 300
           RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT
Sbjct: 241 RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT 300

Query: 301 IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA 360
           IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA
Sbjct: 301 IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA 360

Query: 361 IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLET 420
           IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLET
Sbjct: 361 IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLET 420

Query: 421 LVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA 480
           LVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA
Sbjct: 421 LVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA 480

Query: 481 GLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRENTTGSDNTDTEGS 536
           GLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRENTTGSDNTDTEGS
Sbjct: 481 GLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRENTTGSDNTDTEGS 536


>gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  942 bits (2434), Expect = 0.0
 Identities = 481/481 (100%), Positives = 481/481 (100%)

Query: 1   MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRK 60
           MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRK
Sbjct: 1   MSDYENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRK 60

Query: 61  VGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLM 120
           VGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLM
Sbjct: 61  VGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLM 120

Query: 121 TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE 180
           TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE
Sbjct: 121 TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE 180

Query: 181 ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ 240
           ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ
Sbjct: 181 ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ 240

Query: 241 RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT 300
           RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT
Sbjct: 241 RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT 300

Query: 301 IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA 360
           IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA
Sbjct: 301 IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA 360

Query: 361 IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLET 420
           IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLET
Sbjct: 361 IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLET 420

Query: 421 LVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA 480
           LVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA
Sbjct: 421 LVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA 480

Query: 481 G 481
           G
Sbjct: 481 G 481


>gi|157743265 caspase recruitment domain family, member 11 [Homo
           sapiens]
          Length = 1154

 Score =  370 bits (949), Expect = e-102
 Identities = 206/480 (42%), Positives = 304/480 (63%), Gaps = 33/480 (6%)

Query: 1   MSDY-----ENDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLV 55
           M DY     + +D  W  +E  R  L+  I+P+++TPYLRQCKV++  DE++VL+ P L 
Sbjct: 8   MDDYMETLKDEEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLP 67

Query: 56  IRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGL 115
            +  + G LLDIL   G +GYV FLESLE YYP+LYK VTGKEP R FS I+   G  GL
Sbjct: 68  SKINRAGRLLDILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGL 127

Query: 116 TQLLMTEVMKLQKKVQ-------DLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEEC 168
           T  LM EV+KLQ++++       +L A L   +D  K++ +    L   QER  ++KEE 
Sbjct: 128 THFLMNEVIKLQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVELLTFQERYYKMKEER 187

Query: 169 EAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVER 228
           ++ + EL + K++NY+LAMR A  SEEK  A+MR+RDLQLEIDQLKH L K E++CK+ER
Sbjct: 188 DSYNDELVKVKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNKMEEECKLER 247

Query: 229 KHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKL---DRSSPYIQVLEE 285
             +LKL++ +E RP +E + EL++E  +L+ + QEL++ +Q GK    D     + +LE 
Sbjct: 248 NQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEH 307

Query: 286 DWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEA 345
           D ++AL D QE  N I++L+++ RQ E  R + +EEKE  EL+C  L KD +MYK R+  
Sbjct: 308 DRKEALEDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNT 367

Query: 346 ILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ 405
           ++LQ+EEV  ERDQA  +R+E   Q+++ L EKD  RKQ+REL EK DE+++++ + EA 
Sbjct: 368 VMLQLEEVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREAC 427

Query: 406 LLAVEGRLRR-------------QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDK 452
           ++ +E +LRR             + L   ++S D  D SPR +      Q+ +D+  S++
Sbjct: 428 IVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTN-----GQEADDSSTSEE 482


>gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]
          Length = 1032

 Score =  285 bits (728), Expect = 1e-76
 Identities = 185/528 (35%), Positives = 286/528 (54%), Gaps = 35/528 (6%)

Query: 7   DDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLLD 66
           +D  W  +EG R  L   ++P+++TPYLRQC+V++  DEE+VLS      R  + G L+D
Sbjct: 24  EDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMD 83

Query: 67  ILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKL 126
           IL+  G +GY AFLE+LE YYP+ +  +TG+EPA+  SMI+D  G  GLTQ LMTEV +L
Sbjct: 84  ILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRL 143

Query: 127 Q-------KKVQDLTA--LLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
           +       ++ Q L A   +  ++    E R++D   ++ QER QRL+E+ EAGS EL R
Sbjct: 144 REARKSQLQREQQLQARGRVLEEERAGLEQRLRDQ--QQAQERCQRLREDWEAGSLELLR 201

Query: 178 CKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERK-------- 229
            K+ENY +AMRLA  SEEK +A++R+RDLQL +DQLK  + + E++C + R+        
Sbjct: 202 LKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGA 261

Query: 230 -HTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSP-----YIQVL 283
               K +   ++  + +L+ EL+ E   L A ++EL+  +Q+      +P      + +L
Sbjct: 262 EEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDIL 321

Query: 284 EEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRI 343
           E DWR+A    QE    + +++ +L+  E  R + ++E E   L+   L+KD  +YK R+
Sbjct: 322 EHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRM 381

Query: 344 EAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCE 403
             +L Q+EE+  ERDQAI +R+ +  Q+++ L EKD  RKQVR L  + DEL   +   E
Sbjct: 382 ATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLE 441

Query: 404 AQLLAVEGRLRRQQ----LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGG 459
                +E +L+R Q    L+    S  L             P  L   + + +  + GG 
Sbjct: 442 GTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGP 501

Query: 460 SPKQPFAALHQEQ------VLRNPHDAGLSSGEPPEKERRRLKESFEN 501
            P     A   E+      +L  P  AG       E++    K SF +
Sbjct: 502 EPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSS 549


>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
           sapiens]
          Length = 1004

 Score =  180 bits (456), Expect = 3e-45
 Identities = 143/464 (30%), Positives = 222/464 (47%), Gaps = 38/464 (8%)

Query: 6   NDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLL 65
           +++  W ++E  R  +   I PSR+TPYLRQ KVL   DEE+VL  P L     + G LL
Sbjct: 15  DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74

Query: 66  DILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMK 125
           D+L+  G  G +AFLESL+ + P +Y  VTG +P   FS        S LT+ L   +  
Sbjct: 75  DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134

Query: 126 LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQ----------RLKEECEAGSREL 175
           LQ   ++L      K+  ++  +     L   + R +          R+K E  A   E+
Sbjct: 135 LQ---EELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEV 191

Query: 176 KRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAE--DDCKVERKHTLK 233
            R K+E   L++  ++  +EK  A  R R LQ E+  LK  L +A     C++E +    
Sbjct: 192 LRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQ-S 250

Query: 234 LRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRD 293
           LR A +Q    E L  L++E   L++    L                 +LE+   +A   
Sbjct: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSLAEK-------------DILEQSLDEARGS 297

Query: 294 HQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            QE    I SLR+     E +R +  EEKE   LQ    +   ++Y++++ A+  Q+ E+
Sbjct: 298 RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL 357

Query: 354 AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ---LLAVE 410
             ERDQA + R+    + ++ L EKD+LR+QV EL ++  EL+ Q+ Q +A+   +L  E
Sbjct: 358 QKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE 417

Query: 411 GRLRR---QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSD 451
            R R    ++ + LV    +    PR   + SL    E   LSD
Sbjct: 418 ARTREPCPREKQRLVRMHAI---CPRDDSDCSLVSSTESQLLSD 458


>gi|16507955 caspase recruitment domain protein 14 isoform 2 [Homo
           sapiens]
          Length = 434

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 68/234 (29%), Positives = 111/234 (47%), Gaps = 23/234 (9%)

Query: 224 CKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVL 283
           C++E +    LR A +Q    E L  L++E   L++    L                 +L
Sbjct: 5   CELELQEQ-SLRTASDQESGDEELNRLKEENEKLRSLTFSLAEK-------------DIL 50

Query: 284 EEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRI 343
           E+   +A    QE    I SLR+     E +R +  EEKE   LQ    +   ++Y++++
Sbjct: 51  EQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKV 110

Query: 344 EAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCE 403
            A+  Q+ E+  ERDQA + R+    + ++ L EKD+LR+QV EL ++  EL+ Q+ Q +
Sbjct: 111 NALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQ 170

Query: 404 AQ---LLAVEGRLRR---QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSD 451
           A+   +L  E R R    ++ + LV    +    PR   + SL    E   LSD
Sbjct: 171 AEPPGVLKQEARTREPCPREKQRLVRMHAI---CPRDDSDCSLVSSTESQLLSD 221



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 37/133 (27%), Positives = 62/133 (46%), Gaps = 15/133 (11%)

Query: 158 QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSL 217
           QE+  R   + E+G  EL R KEEN  L   L     EK         L+  +D+ + S 
Sbjct: 10  QEQSLRTASDQESGDEELNRLKEENEKL-RSLTFSLAEKDI-------LEQSLDEARGSR 61

Query: 218 MKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSS 277
            +      VER H+L+ R    +R  +E  WE ++E+ LLQ +  ++   +   K++   
Sbjct: 62  QEL-----VERIHSLRERAVAAER-QREQYWE-EKEQTLLQFQKSKMACQLYREKVNALQ 114

Query: 278 PYIQVLEEDWRQA 290
             +  L+++  QA
Sbjct: 115 AQVCELQKERDQA 127



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 35/160 (21%), Positives = 72/160 (45%), Gaps = 14/160 (8%)

Query: 112 ESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAG 171
           ESG  +L    + +  +K++ LT  L+ KD   + L       ++  ER+  L+E   A 
Sbjct: 21  ESGDEEL--NRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAA 78

Query: 172 SRELKRCKEENYDLAMRLAHQSEEKGAALMRNR--DLQLEIDQL---KHSLMKAEDDCKV 226
            R+ ++  EE     ++   Q  +    L R +   LQ ++ +L   +     A D  + 
Sbjct: 79  ERQREQYWEEKEQTLLQF--QKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQR 136

Query: 227 ERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEA 266
           E   +L     +E+   +  ++EL  +   L+ ++++L+A
Sbjct: 137 EISQSL-----VEKDSLRRQVFELTDQVCELRTQLRQLQA 171


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 98/419 (23%), Positives = 184/419 (43%), Gaps = 34/419 (8%)

Query: 123 VMKLQKKVQDLTALLSSKDDFIKELRVKDSLL----RKHQERVQRLKEECEAGSRELKRC 178
           V +L+ + +DL + L     F  EL    S +    +K    ++ L +E +A S EL R 
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212

Query: 179 KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAM 238
              + +L  + A   E+         ++QL + +LK  L +A+          L L    
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK----------LLLPQQQ 262

Query: 239 EQRPSQELLWELQQEKALLQARVQELEA-----SVQEGKLDRSSPYIQVLEEDWRQALRD 293
            Q  +  L  ELQ   A LQA+V+E E        QE K+ R    IQ  EE  ++    
Sbjct: 263 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEK 322

Query: 294 HQEQANTIFSLRKDLRQGE------ARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAIL 347
            +EQ   I    + +R+ E        ++R  EE  M+E +    R++  M++   E  +
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKMRRQEEMMWEK--EEKM 379

Query: 348 LQMEEVAIERDQAIATREE-LHAQH-ARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ 405
            + EE+  E+++ I   EE +H Q   R  +EK    +++RE  EK  E + ++++ E +
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEK 438

Query: 406 LLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPF 465
           +   E ++R Q+ +       + +    R +E    Q+ E+    ++         +Q  
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR--QEQEEMWRQEEKIHEQEEIWRQKE 496

Query: 466 AALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFEN-YRRKRALRKMQKGWRQGEEDRE 523
               QE+ +R   +      E   ++  +++E  E  +R++  +R+ ++ WR+ E+  E
Sbjct: 497 KMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555



 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 78/434 (17%), Positives = 188/434 (43%), Gaps = 65/434 (14%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFIKE----LRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
           ++ + ++K+Q+    +  +++ I+E    +R ++ ++ + +E+++R +E       +++R
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367

Query: 178 CKEENYDLAMRLAHQSEEKGAALMRNRDLQ----------------LEIDQLKHSLMKAE 221
            +E  ++   ++  Q E       + R+L+                 E ++++    + E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427

Query: 222 DDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQ 281
            + K+ R+   K+R   E+   QE     Q+EK   Q +++E E   ++ ++ R    I 
Sbjct: 428 QEAKMWRQEE-KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH 486

Query: 282 VLEEDWRQALRDHQEQANTIFSLRKDLRQGEARR---LRCMEEKEMFELQCLALRKDSKM 338
             EE WRQ  + H+++        K  RQ E  R    +  E++E    Q   +R+  +M
Sbjct: 487 EQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM 546

Query: 339 YKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQ----------VREL 388
           ++          EE  +   + I   E+   Q  +  ++++ +R+Q          +RE 
Sbjct: 547 WR----------EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQ 596

Query: 389 GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQ 448
            EK  E + ++++ E ++   E +++ Q+ +        ++   R  +E++  Q+ +  +
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE-----QEEKIREQEEMTQEQEEKMGE 651

Query: 449 LSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRAL 508
             +K C               QE+ ++   +      E   ++ ++++E  E  R +  +
Sbjct: 652 QEEKMC--------------EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM 697

Query: 509 RKMQ--KGWRQGEE 520
            + Q  K W Q E+
Sbjct: 698 MQEQEEKMWEQEEK 711


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 95/410 (23%), Positives = 184/410 (44%), Gaps = 37/410 (9%)

Query: 123 VMKLQKKVQDLTALLSSKDDFIKELRVKDSLL----RKHQERVQRLKEECEAGSRELKRC 178
           V +L+ + +DL + L     F  EL    S +    +K    ++ L +E +A S EL R 
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212

Query: 179 KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAM 238
              + +L  + A   E+         ++QL + +LK  L +A+          L L    
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK----------LLLPQQQ 262

Query: 239 EQRPSQELLWELQQEKALLQARVQELEA-----SVQEGKLDRSSPYIQVLEEDWRQALRD 293
            Q  +  L  ELQ   A LQA+V+E E        QE K+ R    IQ    +W + +  
Sbjct: 263 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ----EWEEKI-- 316

Query: 294 HQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            QEQ   I    + +R+ E +  R  +E+ M+E +    R++  M++   E  + ++EE+
Sbjct: 317 -QEQEEKIREQEEKIREQEEKMRR--QEEMMWEKEEKMRRQEEMMWEK--EEKMRRLEEM 371

Query: 354 AIERDQAIATREE-LHAQH-ARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEG 411
             E+++ I   EE +H Q   R  +EK    +++RE  EK  E + ++++ E ++   E 
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEKIREQEE 430

Query: 412 RLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQE 471
           ++R Q+ +       + +    R +E    Q+ E+    ++         +Q    +H++
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKR--QEQEEMWRQEEKIREQEEIWRQK-EKMHEQ 487

Query: 472 QVLRNPHDAGLSSGEPPEKERRRLKESFEN-YRRKRALRKMQKGWRQGEE 520
           + +R   +      E    +  +++E  E  +R++  +R+ ++  R+ EE
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE 537



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 58/305 (19%), Positives = 153/305 (50%), Gaps = 16/305 (5%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFIKE----LRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
           ++ + ++K+Q+    +  +++ I+E    +R ++ ++ + +E+++R +E       +++R
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367

Query: 178 CKEENYDLAMRLAHQSEE--KGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLR 235
            +E  ++   ++    E+  +   +    + + E ++++    + E + K+ R+   K+R
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-KIR 426

Query: 236 HAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQ 295
              E+   QE     Q+EK   Q +++E E   ++ ++ R    I+  EE WRQ  + H+
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE 486

Query: 296 EQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAI 355
           ++      +RK   +   +  +  +++E    Q   + +  +  +++ E I  Q E++  
Sbjct: 487 QE-----KIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIR- 540

Query: 356 ERDQAIATREELHAQHARGLQEKDALRKQ---VRELGEKADELQLQVFQCEAQLLAVEGR 412
           E+++ +  +EE   +    +QE++ +R+Q   +RE  EK  E + ++ + E ++   E +
Sbjct: 541 EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEK 600

Query: 413 LRRQQ 417
           +R Q+
Sbjct: 601 IREQE 605



 Score = 33.1 bits (74), Expect = 0.66
 Identities = 33/180 (18%), Positives = 84/180 (46%), Gaps = 25/180 (13%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFI----KELRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
           +V + ++K+ D    +  +++ +    +++R ++  +R+ +E++ R +EE      E   
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKI-REQEEMMQEQEEKMG 554

Query: 178 CKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHA 237
            +EE      ++  Q E       + R+ + +I + K  + + E+    + +   +    
Sbjct: 555 EQEEKMQEQEKMRRQEE-------KIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEM 607

Query: 238 MEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQ 297
           M+++  +E +WE +++    + ++QE     QE K+ R        E+ W Q +R  Q++
Sbjct: 608 MQEQ--EEKMWEQEEKMCEQEEKMQE-----QEEKMRRQE------EKMWEQEVRLRQQE 654


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 96/410 (23%), Positives = 181/410 (44%), Gaps = 36/410 (8%)

Query: 123 VMKLQKKVQDLTALLSSKDDFIKELRVKDSLL----RKHQERVQRLKEECEAGSRELKRC 178
           V +L+ + +DL + L     F  EL    S +    +K    ++ L +E +A S EL R 
Sbjct: 214 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 273

Query: 179 KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAM 238
              + +L  + A   E+         ++QL + +LK  L +A+          L L    
Sbjct: 274 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK----------LLLPQQQ 323

Query: 239 EQRPSQELLWELQQEKALLQARVQELEA-----SVQEGKLDRSSPYIQVLEEDWRQALRD 293
            Q  +  L  ELQ   A LQA+V+E E        QE K+ R    IQ    +W + +  
Sbjct: 324 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQ----EWEEKI-- 377

Query: 294 HQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            QEQ   I    + +R+ E +  R  +E+ M+E +    R++  M++   E  + + EE+
Sbjct: 378 -QEQEEKIREQEEKIREQEEKMRR--QEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEM 432

Query: 354 AIERDQAIATREE-LHAQH-ARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEG 411
             E+++ I   EE +H Q   R  +EK    +++RE  EK  E + ++++ E ++   E 
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEKIREQEE 491

Query: 412 RLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQE 471
           ++R Q+ +       + +    R +E    Q+ E+    ++         +Q      QE
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKR--QEQEEMWRQEEKIREQEEIWRQKEKIHEQE 549

Query: 472 QVLRNPHDAGLSSGEPPEKERRRLKESFEN-YRRKRALRKMQKGWRQGEE 520
           + +R   +      E    +  +++E  E  +R++  +R+ ++  R+ EE
Sbjct: 550 EKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE 599



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 67/347 (19%), Positives = 169/347 (48%), Gaps = 19/347 (5%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFIKE----LRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
           ++ + ++K+Q+    +  +++ I+E    +R ++ ++ + +E+++R +E       +++R
Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428

Query: 178 CKEENYDLAMRLAHQSEE--KGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLR 235
            +E  ++   ++    E+  +   +    + + E ++++    + E + K+ R+   K+R
Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-KIR 487

Query: 236 HAMEQ-RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              E+ R  +E +W  Q+EK   Q +++E E   ++ ++ R    I+  EE WRQ  + H
Sbjct: 488 EQEEKIREQEEKMWR-QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIH 546

Query: 295 QEQANTIFSLRKDLRQGEA---RRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQME 351
           +++        K  RQ E    +  +  E++E    Q   +R+  +  +++ E I  + E
Sbjct: 547 EQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI-REQE 605

Query: 352 EVAIERDQAIATREELHAQHARGLQE-KDALRKQ---VRELGEKADELQLQVFQCEAQLL 407
           E+  E+++ +  +EE   +    +QE ++ +R+Q   +RE  +K  E + ++ + E  + 
Sbjct: 606 EMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 665

Query: 408 AVEGRLRRQQLETLVLSSDLEDGSP--RRSQELSLPQDLEDTQLSDK 452
             E ++  Q+ +       +++     RR +E    Q++   Q  +K
Sbjct: 666 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 712


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 80/375 (21%), Positives = 167/375 (44%), Gaps = 32/375 (8%)

Query: 155 RKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK 214
           +K    ++ L +E +A S EL R    N +L  + A   E+   A     ++QL + +LK
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214

Query: 215 HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV--QEGK 272
             L +A+      + +TL           QE +W  ++E    + ++++ E  +  QE +
Sbjct: 215 RKLERAKFLLPQVQTNTL-----------QEEMWRQEEELREQEKKIRKQEEKMWRQEER 263

Query: 273 LDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCME------EKEMFE 326
           L      ++  EE  R+  +  +EQ   +    K+LR  E ++LR  E      E++M+E
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR--EQKKLREQEEQMQEQEEKMWE 321

Query: 327 LQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVR 386
            +     ++ KM+  R E  L + E+   E++Q +  +EE   +    L+EK+   ++  
Sbjct: 322 QEEKMREQEEKMW--RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 379

Query: 387 ELGEKADELQLQ--VFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
           ++ E+ +++Q +  + + E ++   E  +R Q+ +      ++ +   +  Q+  LP+  
Sbjct: 380 KMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 439

Query: 445 EDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRR 504
           E     +K         +Q      QE+ +R+  +      +   +E+ R +E     + 
Sbjct: 440 EKLWEQEK-------MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492

Query: 505 KRALRKMQKGWRQGE 519
           ++   + QK W Q E
Sbjct: 493 EKMRDQEQKMWDQEE 507



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 86/472 (18%), Positives = 202/472 (42%), Gaps = 48/472 (10%)

Query: 82  SLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKD 141
           SLELY   +  +   K+ A +   +  A  E    QL    V +L++K++    LL    
Sbjct: 172 SLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQL---NVKELKRKLERAKFLLPQVQ 228

Query: 142 DFI---------KELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQ 192
                       +ELR ++  +RK +E++ R +E       +++  +E+      RL  Q
Sbjct: 229 TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ 288

Query: 193 SEEKGAALMRNRDLQL-EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQR-PSQELLWEL 250
            +E     +R ++ +L E  +L+    + ++  +   +   K+R   E+    +E LWE 
Sbjct: 289 EKE-----LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 343

Query: 251 QQEKALLQARVQELEASV--QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDL 308
           +++    + ++++ E  +  Q+ +L      ++  E+ W Q   +  ++   I    K +
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ--EEKMQEEERIREREKKM 401

Query: 309 RQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRI---------EAILLQMEEVAIERDQ 359
           R+ E   +R  EEK   + + +  +++ +  + R+         +  + + EE   E+++
Sbjct: 402 RE-EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460

Query: 360 AIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
            I  +EE+  Q  + +  ++ +R+Q  ++ E+ ++++ Q    E ++   E R+  Q   
Sbjct: 461 KIRDQEEMWGQEKK-MWRQEKMREQEDQMWEQEEKMRDQ----EQKMWDQEERMWEQDER 515

Query: 420 TLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHD 479
                  + +      QE  + ++ + TQ  +K         ++      +E+ +R   +
Sbjct: 516 LREKEERMREQKKMWQQEEKMREE-KKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 574

Query: 480 AGLSSGEPPEKERRRLKESFENY---------RRKRALRKMQKGWRQGEEDR 522
                 E  +++  +++E  E           + ++   + +K W Q EED+
Sbjct: 575 MMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 60/319 (18%), Positives = 152/319 (47%), Gaps = 33/319 (10%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERV----------QRLKEECEA- 170
           E M+ ++++++    +  +++ ++E   K   ++K +E +          QRL E+ E  
Sbjct: 386 EKMQEEERIREREKKMREEEETMREQEEK---MQKQEENMWEQEEKEWQQQRLPEQKEKL 442

Query: 171 -GSRELKRCKEENYDLAMRLAHQSEEKGAA--LMRNRDLQLEIDQL--KHSLMKAEDDCK 225
               +++  +E+ ++   ++  Q E  G    + R   ++ + DQ+  +   M+ ++   
Sbjct: 443 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502

Query: 226 VERKHTL-----KLRHAMEQRPSQELLWELQQEKALLQARVQELEASV--QEGKLDRSSP 278
            +++  +     +LR   E+   Q+ +W+ Q+EK   + + QE E     QE K+ R   
Sbjct: 503 WDQEERMWEQDERLREKEERMREQKKMWQ-QEEKMREEKKTQEQEKKTWDQEEKM-REEE 560

Query: 279 YIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKM 338
            ++  E+  R+     +EQ   +    + +R+ E +     +E++M E +     ++ KM
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE--QEEKMQEQEEKMWEQEEKM 618

Query: 339 YKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQ 398
           ++   E  + + EE+  E+++ +  +EE   +    ++E++   +++RE  EK    + +
Sbjct: 619 WEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE---EKMREQEEKMQGQEEK 675

Query: 399 VFQCEAQLLAVEGRLRRQQ 417
           + + E ++   E ++R Q+
Sbjct: 676 MREQEEKMQGQEEKMREQE 694



 Score = 30.8 bits (68), Expect = 3.3
 Identities = 43/181 (23%), Positives = 72/181 (39%), Gaps = 28/181 (15%)

Query: 343 IEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQC 402
           IE +  + + +++E  +   T EEL  ++A  LQEK      +R    +  E+QL V + 
Sbjct: 161 IEELTKERDALSLELYRNTITNEELKKKNAE-LQEK------LRLAESEKSEIQLNVKEL 213

Query: 403 EAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPK 462
           + +L   +  L + Q  TL              QE    Q+ E  +   K         K
Sbjct: 214 KRKLERAKFLLPQVQTNTL--------------QEEMWRQEEELREQEKK-------IRK 252

Query: 463 QPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDR 522
           Q      QE+ LR          E   ++ +RL+E  +  R +    + QK  R+ EE  
Sbjct: 253 QEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQM 312

Query: 523 E 523
           +
Sbjct: 313 Q 313


>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
          Length = 1478

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 90/363 (24%), Positives = 166/363 (45%), Gaps = 40/363 (11%)

Query: 114  GLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSR 173
            G  Q L  +V+ LQ K++   A L  +D    +L + +++LR+H+  VQ+LKE+ EA +R
Sbjct: 783  GEVQRLQAQVVDLQAKMR---AALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNR 839

Query: 174  ----ELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERK 229
                EL +C E    L    A +++++   L   R LQ E+ Q K S     ++ ++E  
Sbjct: 840  AHVQELLQCSEREGALQEERADEAQQREEEL---RALQEELSQAKCS----SEEAQLEHA 892

Query: 230  HTLKLRHAMEQRPSQ------ELLWELQQEKALLQARVQELE-----ASVQEGKLDRSSP 278
               +  H      ++       L  E ++ +  L   VQEL+     AS +   L+R   
Sbjct: 893  ELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVA 952

Query: 279  YIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKM 338
             +Q  +E  ++ L+  +  A ++  L+  L Q E +R + ++E    EL  L  +  +++
Sbjct: 953  GLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAE-QRAQSLQEAAHQELNTLKFQLSAEI 1011

Query: 339  --YKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQ 396
              Y+ R++      EE    R Q     EE   Q     +  + L+    ++GEK     
Sbjct: 1012 MDYQSRLKN---AGEECKSLRGQL----EEQGRQLQAAEEAVEKLKATQADMGEKLSCTS 1064

Query: 397  LQVFQCEAQLLA--VEGRLRRQQLETLVLSSDLEDGSPRRSQELS-LPQDLEDTQLSDKG 453
              + +C+A +L    EG   R+ LE      +LE  + +  +  + L Q++ + + +D+ 
Sbjct: 1065 NHLAECQAAMLRKDKEGAALREDLER--TQKELEKATTKIQEYYNKLCQEVTNRERNDQK 1122

Query: 454  CLA 456
             LA
Sbjct: 1123 MLA 1125



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/364 (23%), Positives = 156/364 (42%), Gaps = 54/364 (14%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEE 181
           E  +L +++Q+L A  SS ++ + ELR +    ++ QE  + L++E  + +R+L+  + +
Sbjct: 465 EADQLWRRLQELLAHTSSWEEELAELRREK---KQQQEEKELLEQEVRSLTRQLQFLETQ 521

Query: 182 NYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKV--ERKHTL-----KL 234
              ++  ++   E+K   +     L  ++  L+        +  V  E+   L      L
Sbjct: 522 LAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSL 581

Query: 235 RHAM-----EQRPSQEL------LWELQQEKALLQARVQELEASVQE--GKLDRSSPYIQ 281
           + A      EQR  QE       + E  QE+ L QA  +ELE  +Q   G+       +Q
Sbjct: 582 QEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQAN-RELEKELQNVVGRNQLLEGKLQ 640

Query: 282 VLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKD 341
            L+ D+ QAL+  +       +++  L   EA +       +  E   LA+RK  +  K 
Sbjct: 641 ALQADY-QALQQRES------AIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKA 693

Query: 342 RI---EAILLQ--------MEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGE 390
           ++   EAIL           EEV   +  A A   EL A  ++  Q+   +     E G+
Sbjct: 694 QMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQ 753

Query: 391 ---------KADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLE---DGSPRRSQEL 438
                    +A EL  Q+   +AQL   +G ++R Q + + L + +    D   +   +L
Sbjct: 754 QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQL 813

Query: 439 SLPQ 442
           S+ +
Sbjct: 814 SMAE 817



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 84/395 (21%), Positives = 156/395 (39%), Gaps = 75/395 (18%)

Query: 144 IKELRVKDSLLRKHQERVQRLKEECEAG----SRELKRCKEENYDLAMRLAHQSEEKGAA 199
           + +L V++  LR+  +++ R  +E  A       +L+  +E       R A +   +   
Sbjct: 239 LDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERG-----RTAAEDNVRLTC 293

Query: 200 LMRNRDLQLEIDQLKHSLMKAEDDC----------KVERKHTLKLRHAMEQRPSQELLWE 249
           L+     Q E+ Q   + +K    C          K E  HT   R     +P   L  E
Sbjct: 294 LVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQP---LAQE 350

Query: 250 LQQEKALLQARVQELEA-----SVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSL 304
           L+  +  L  + Q L +     ++ + K D +S      E     A ++ QE    + +L
Sbjct: 351 LEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQAL 410

Query: 305 RKDLRQGEA--RRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAI----ERD 358
            ++  + E   R+     E+ + ELQ   L++D++   +R+   +  ++E       E D
Sbjct: 411 ERERTKVEEVNRQQSAQLEQLVKELQ---LKEDARASLERLVKEMAPLQEELSGKGQEAD 467

Query: 359 QAIATREELHA--------------QHARGLQEKDALRKQVRELGEKADELQLQVFQCEA 404
           Q     +EL A              +  +  +EK+ L ++VR L  +   L+ Q+ Q   
Sbjct: 468 QLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQ 527

Query: 405 QLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQP 464
            +                  SDLE+    + ++L   +D    Q+     LAG   P+ P
Sbjct: 528 HV------------------SDLEE----QKKQLIQDKDHLSQQVGMLERLAGPPGPELP 565

Query: 465 FAALHQEQVLRNPHDAGLSSG-EPPEKERRRLKES 498
            A    E ++  P ++ L      PE+E+R L+E+
Sbjct: 566 VAGEKNEALV--PVNSSLQEAWGKPEEEQRGLQEA 598


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 103/425 (24%), Positives = 191/425 (44%), Gaps = 70/425 (16%)

Query: 113 SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQ------ERVQRLKE 166
           + LT  L T    +Q++ Q+L  L     +  K+ ++  +L ++ Q       +V++L  
Sbjct: 501 ASLTSELTTLNATIQQQDQELAGLKQQAKE--KQAQLAQTLQQQEQASQGLRHQVEQLSS 558

Query: 167 ECEAGSRELKRCKEEN----YDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAED 222
             +   ++LK   E+      D A +LA  +EE+ A+L R RD  L+  QL+   ++ E 
Sbjct: 559 SLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL-RERDAALK--QLE--ALEKEK 613

Query: 223 DCKVERKHTLKLRHAMEQRPS-QELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQ 281
             K+E     +L+ A E R S Q  + + Q+EKA L  +V+EL+A V+  + ++     Q
Sbjct: 614 AAKLEILQQ-QLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672

Query: 282 VLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKD 341
           V E + +  LR  Q++A                + R  +EK+  + Q  AL++  K+ K 
Sbjct: 673 VAELELQ--LRSEQQKA--------------TEKERVAQEKDQLQEQLQALKESLKVTKG 716

Query: 342 RIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRE--LGEKADELQLQ- 398
            +E    +  +   E+ + I+   EL A+    +++    RK++ E   G K  E +LQ 
Sbjct: 717 SLEEEKRRAADALEEQQRCIS---ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773

Query: 399 ---VFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD-LEDTQLSDKGC 454
                Q E ++      LRR+  E +      E    +  +E++  ++  ED+Q      
Sbjct: 774 LGEAHQAETEV------LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ------ 821

Query: 455 LAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKG 514
                  +  + A+ QEQ+        ++  E  EK R+ L+E+ E      +  ++Q  
Sbjct: 822 -----QEEAQYGAMFQEQL--------MTLKEECEKARQELQEAKEKVAGIESHSELQIS 868

Query: 515 WRQGE 519
            +Q E
Sbjct: 869 RQQNE 873



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 78/361 (21%), Positives = 150/361 (41%), Gaps = 45/361 (12%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK---HQERVQR--LKEECEAG 171
            Q +  + ++ QK   DL+ L        KE+   ++L+RK    QE   R  +KE   AG
Sbjct: 886  QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG 945

Query: 172  SRELKRCKEEN--YDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERK 229
             R+ +  +E+      + + A Q+ E+ A  M N     E+++L+ +LM+++   + ER 
Sbjct: 946  DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGN-----ELERLRAALMESQGQQQEER- 999

Query: 230  HTLKLRHAMEQRPSQELLWE---LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEED 286
                     ++R    L  E    Q + AL +A   ELE  +Q   L+        L+E 
Sbjct: 1000 -------GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA-LNEQRVEFATLQEA 1051

Query: 287  WRQALRDHQEQANTIFSLR----------KDLRQGEARRLRCMEEKEMFELQCLALRKDS 336
               AL + + +   +  LR          ++LRQ   +    + +KE         + ++
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111

Query: 337  KMYKD----RIEAILLQM----EEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                +    ++EA+  ++    ++   +++QA +    L A+ A   +   AL     +L
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171

Query: 389  GEKADEL---QLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLE 445
             EKA EL   Q  +   + +L A   +++          + +  G     ++ SL   LE
Sbjct: 1172 EEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLE 1231

Query: 446  D 446
            +
Sbjct: 1232 E 1232



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 87/384 (22%), Positives = 153/384 (39%), Gaps = 41/384 (10%)

Query: 97   KEPARVFSMIIDASGESGLTQLLMTE--VMKLQKKVQDLTALLSSKDDFIKELRVKDSLL 154
            KEPAR      +   E    Q   T+  +  ++++ + +   L      + E + +    
Sbjct: 939  KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998

Query: 155  RKHQER-VQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQL 213
            R  QER V RL +E      +L   K    +L MRL +   E+          ++E   L
Sbjct: 999  RGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ----------RVEFATL 1048

Query: 214  KHSLMKAEDDCKVERKHTLKLR--HAMEQRPSQELLWELQQEKALLQARVQELEA----- 266
            + +L  A  + + + +   KLR   A + +  +EL   ++Q K  L  + +E  +     
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108

Query: 267  SVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFE 326
            S   G+ + + P ++ L  +  +  +  Q+Q     SL + L   EA R    E     E
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL---EAERASRAERDSALE 1165

Query: 327  LQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA---IATREELHAQHARGLQEKDALRK 383
                 L + ++       A+     E+A  R +        +E  AQ ARG QE +    
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225

Query: 384  QVRELGEKADELQLQVFQCEAQ-------LLA-------VEGRLRRQQLETLVLSS-DLE 428
             +  L E+   L  QV + E +       ++A       +E RLR  Q ET   S+   E
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285

Query: 429  DGSPRRSQELSLPQDLEDTQLSDK 452
              S  R +  SL ++ E  +++ +
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASE 1309



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 78/351 (22%), Positives = 145/351 (41%), Gaps = 39/351 (11%)

Query: 110 SGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVK----DSLLRKHQERV---Q 162
           S ++ +TQ    E  +L +KV++L A + +      E + +    +  LR  Q++    +
Sbjct: 633 SAQTSVTQA-QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691

Query: 163 RLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAED 222
           R+ +E +    +L+  KE    L +      EEK  A     + Q  I +LK       +
Sbjct: 692 RVAQEKDQLQEQLQALKES---LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748

Query: 223 DCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDR---SSPY 279
             K ERK   +     E+   + L   LQQ     QA  + L   + E    +    S  
Sbjct: 749 QHKRERKELEE-----ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803

Query: 280 IQVLEE--DWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSK 337
            Q+++E   WR+   D Q++         + + G   + + M  KE    +C   R++ +
Sbjct: 804 EQLVKEVAAWRERYEDSQQE---------EAQYGAMFQEQLMTLKE----ECEKARQELQ 850

Query: 338 MYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQL 397
             K+++  I    E     +   +A   ELHA  AR LQ+      + ++L +    LQ 
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELA---ELHANLARALQQVQEKEVRAQKLADDLSTLQE 907

Query: 398 QVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQ 448
           ++     ++  +E  +R+   +    S +L    P R+ +   P+ LE+ Q
Sbjct: 908 KMAATSKEVARLETLVRKAGEQQETASRELVK-EPARAGDRQ-PEWLEEQQ 956



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 76/344 (22%), Positives = 142/344 (41%), Gaps = 74/344 (21%)

Query: 107 IDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRV-------KDSLLRKHQE 159
           +  S  S +  +L T   ++++  + L    S++D+   EL         KD+ +   Q+
Sbjct: 197 LSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQ 256

Query: 160 RVQRLK--EECEAGS----RELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQL 213
           R+ RL    E +A S    +EL+  +++N  L MRL H++      L + +DL+ E  Q+
Sbjct: 257 RIDRLALLNEKQAASPLEPKELEELRDKNESLTMRL-HET------LKQCQDLKTEKSQM 309

Query: 214 KHSLMKAEDDCKVERKHTLKLRH-AMEQRPSQELLWELQQEKALLQARVQELEASVQEGK 272
              + +  ++       + KLR  A   +  Q+ L EL +E +  +A  + LE   Q   
Sbjct: 310 DRKINQLSEE---NGDLSFKLREFASHLQQLQDALNELTEEHS--KATQEWLEKQAQ--- 361

Query: 273 LDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLAL 332
                     LE++   AL+D +         + ++ QG+  +L    E+ + +LQ    
Sbjct: 362 ----------LEKELSAALQDKK-----CLEEKNEILQGKLSQL----EEHLSQLQ---- 398

Query: 333 RKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKA 392
             +    K  +   +LQ+E +  E     A   +L A                     + 
Sbjct: 399 -DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA---------------------RV 436

Query: 393 DELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQ 436
           + L+ +  Q EA+LLA  G    ++ +   L +DL+      SQ
Sbjct: 437 EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 480



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 86/411 (20%), Positives = 165/411 (40%), Gaps = 69/411 (16%)

Query: 106  IIDASGESG-LTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRL 164
            +++  GES  L +L+M E  K QK  + L  L +           + S LR   E VQ L
Sbjct: 1241 VLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALR---EEVQSL 1297

Query: 165  KEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMR--NRDLQLEIDQLKHS------ 216
            +EE E      +  ++E    A R     +E  A   +   ++  L   QL+H+      
Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357

Query: 217  --LMKAEDDCK--------VERKHTLKLRHAM--------EQRPSQELLWEL-------- 250
              L+ A+  C+         E++H  +L  +         E   +Q  L EL        
Sbjct: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA 1417

Query: 251  QQEKALLQARVQE---------------LEASVQEGKLDRSSPYIQVLEEDWRQALRDHQ 295
            +QE+   Q R ++               L A    G  +R++   Q LE +  QA   + 
Sbjct: 1418 EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1477

Query: 296  EQ-------ANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILL 348
            ++       A T  +  +   Q  AR L  M  K  +E   + + ++ + +++  + +  
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAK--YEGAKVKVLEERQRFQEERQKLTA 1535

Query: 349  QMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLA 408
            Q+E++ + + +     EEL  + A   Q     +++++ +  +  E Q +  + +AQL  
Sbjct: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE 1595

Query: 409  VEGRLRRQQLETLVLSSDLE------DGSPRRSQELSLP-QDLEDTQLSDK 452
            ++ +L +++         +E      D   +++QEL    + LE  Q  +K
Sbjct: 1596 LQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK 1646


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2324

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2325 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2360

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2479

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2235 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2285 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2337



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2442 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2500 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2602

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2662

Query: 482  LSSGE 486
            + S E
Sbjct: 2663 ILSAE 2667



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1617 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1672

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1783

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1784 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1961 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1252 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1311

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1312 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1366 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1411

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1412 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1530

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1591 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1633



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1249 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1306

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1307 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1358

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1639

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1764

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1765 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1816

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1817 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1866

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1924

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 1983

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 504  RKR 506
            +KR
Sbjct: 2044 QKR 2046



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1830 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1947 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 1997

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 1998 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2048

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2049 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2082

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2328

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2329 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2364

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2483

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2238

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2239 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2288

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2289 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2341



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2386 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2446 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2503

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2504 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2550

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2606

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2666

Query: 482  LSSGE 486
            + S E
Sbjct: 2667 ILSAE 2671



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1621 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1676

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1677 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1736

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1787

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1788 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1965 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1256 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1315

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1316 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1370 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1415

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1416 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1475

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1534

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1595 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1637



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1253 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1310

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1311 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1362

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1643

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1768

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1769 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1820

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1821 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1870

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1928

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 1987

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047

Query: 504  RKR 506
            +KR
Sbjct: 2048 QKR 2050



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1834 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1891

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1892 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1950

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1951 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 2001

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 2002 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2052

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2053 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2086

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2324

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2325 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2360

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2479

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2235 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2285 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2337



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2442 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2500 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2602

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2662

Query: 482  LSSGE 486
            + S E
Sbjct: 2663 ILSAE 2667



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1617 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1672

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1673 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1783

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1784 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1961 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1252 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1311

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1312 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1366 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1411

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1412 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1530

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1591 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1633



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1249 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1306

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1307 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1358

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1639

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1764

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1765 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1816

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1817 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1866

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1924

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 1983

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043

Query: 504  RKR 506
            +KR
Sbjct: 2044 QKR 2046



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1830 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1947 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 1997

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 1998 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2048

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2049 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2082

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2292

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2293 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2328

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2447

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2202

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2203 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2252

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2253 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2305



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2350 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2410 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2467

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2468 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2514

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2570

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2571 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2630

Query: 482  LSSGE 486
            + S E
Sbjct: 2631 ILSAE 2635



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1585 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1640

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1641 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1700

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1751

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1752 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1929 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1220 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1279

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1280 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1334 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1379

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1380 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1439

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1498

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1559 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1601



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1217 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1274

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1275 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1326

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1607

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1680 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1732

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1733 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1784

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1785 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1834

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1892

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 1951

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011

Query: 504  RKR 506
            +KR
Sbjct: 2012 QKR 2014



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1798 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1855

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1856 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1914

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1915 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 1965

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 1966 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2016

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2017 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2050

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2461

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2462 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2497

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2616

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2372 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2421

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2422 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2474



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2519 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2579 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2636

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2637 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2683

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2739

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2740 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2799

Query: 482  LSSGE 486
            + S E
Sbjct: 2800 ILSAE 2804



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1754 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1809

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1810 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1869

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1920

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1921 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 2098 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1389 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1448

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1449 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1503 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1548

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1549 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1608

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1609 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1667

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1728 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1770



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1386 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1443

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1444 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1495

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1776

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1849 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1901

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1902 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1953

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1954 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 2003

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 2061

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 2120

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180

Query: 504  RKR 506
            +KR
Sbjct: 2181 QKR 2183



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1967 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 2024

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 2025 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 2083

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 2084 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 2134

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 2135 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2185

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2186 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2219

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2302

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2303 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2338

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2457

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2213 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2262

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2263 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2315



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2360 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2420 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2477

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2478 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2524

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2580

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2640

Query: 482  LSSGE 486
            + S E
Sbjct: 2641 ILSAE 2645



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1595 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1650

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1651 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1710

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1761

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1762 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1939 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1230 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1289

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1290 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1344 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1389

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1390 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1449

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1450 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1508

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1569 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1611



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1227 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1284

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1285 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1336

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1617

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1690 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1742

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1743 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1794

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1795 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1844

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1902

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 1961

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021

Query: 504  RKR 506
            +KR
Sbjct: 2022 QKR 2024



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1808 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1865

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1866 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1924

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1925 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 1975

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 1976 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2026

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2027 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2060

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2310

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2311 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2346

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2465

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2566



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2221 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2270

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2271 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2323



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2368 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2428 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2485

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2486 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2532

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2588

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2589 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2648

Query: 482  LSSGE 486
            + S E
Sbjct: 2649 ILSAE 2653



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1602

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1603 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1658

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1659 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1718

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1769

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1770 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1947 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1238 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1297

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1298 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1352 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1397

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1398 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1457

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1458 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1516

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1577 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1619



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1235 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1292

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1293 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1344

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1524

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1625

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1626 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1698 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1750

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1751 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1802

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1803 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1852

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1910

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 1969

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029

Query: 504  RKR 506
            +KR
Sbjct: 2030 QKR 2032



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1816 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1873

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1874 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1932

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1933 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 1983

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 1984 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2034

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2035 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2068

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 64/401 (15%)

Query: 159  ERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQL-EIDQLKHSL 217
            E +QRLK E    +R+  + +EE + + +++   S+ K      NR L L + D  +  L
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293

Query: 218  MKAEDDCKVERKHTLKLRHAMEQRPSQELLWE--LQQEKALLQARVQELEASVQEGKLDR 275
             +  +  K   +   +L  A ++      L E  L Q++AL +  ++E   +VQE    R
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT--R 2351

Query: 276  SSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKD 335
                 ++L++                   +K+L Q +ARRL+  E+KE    Q   L ++
Sbjct: 2352 LKAEAELLQQ-------------------QKELAQEQARRLQ--EDKEQMAQQ---LAEE 2387

Query: 336  SKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADEL 395
            ++ ++  +EA   +  E++ E ++      E+    AR  ++    RKQ  E+GEK    
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447

Query: 396  QL---------QVFQCEAQL--------------LAVEGRLRRQQLETLVLSSDLEDGSP 432
            +L         Q  + + Q               L  E    +Q+ + L L S+ E  + 
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTV 2506

Query: 433  RRSQELSLPQDLEDTQLSDKGCLAGG----GSPKQPFAALHQEQVLR--NPHDAGLSSGE 486
            ++ Q L   Q L+ + LS+K  L          K     L Q++V +     +      +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566

Query: 487  PPEKERRRLKESFENYRRKR-----ALRKMQKGWRQGEEDR 522
              E+ER+RL  S E  RR++      +R+ Q+  +Q E+ R
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2607



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 74/298 (24%), Positives = 126/298 (42%), Gaps = 22/298 (7%)

Query: 126  LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDL 185
            +Q+K Q+L   L  +   + +LR +    R+  E  +  + + E  + + +R  EE   L
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144

Query: 186  AMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQE 245
                  Q++ +  A      L+ E +Q      +AE     +++         ++   Q 
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204

Query: 246  LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
            L  + Q E+ L   R+Q  E   Q+  LD     +Q L+ +  +A R   +    +FS+R
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLDEE---LQRLKAEATEAARQRSQVEEELFSVR 2261

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ----MEEVAIERDQAI 361
              ++  E  +L+   E E    + L LR      KD  +  L +    M++VA E  +  
Sbjct: 2262 --VQMEELSKLKARIEAEN---RALILRD-----KDNTQRFLQEEAEKMKQVAEEAARLS 2311

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE 419
               +E  A   R L E+D    Q R L EK  + ++Q  Q EA  L  E  L +QQ E
Sbjct: 2312 VAAQE--AARLRQLAEEDL--AQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKE 2364



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 88/425 (20%), Positives = 180/425 (42%), Gaps = 73/425 (17%)

Query: 116  TQLLMTEVMKLQKKVQDLTALLS------------SKDDFIKELRVKDSLLRKHQERVQ- 162
            TQ  + E  +  K+V +  A LS            +++D  ++  + + +L++  + VQ 
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348

Query: 163  --RLKEECEA-------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE---- 209
              RLK E E           + +R +E+   +A +LA +++     L   R  QLE    
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408

Query: 210  -------IDQLKHSLMKAEDDCKVERKHTLKLRH-------AMEQRPSQELLWELQQEKA 255
                   + ++  +  +AE+D +  RK   ++         A +++ +     E+Q++++
Sbjct: 2409 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468

Query: 256  -----LLQARVQELEASVQEGKLDRSSPYIQVLEEDWR-----QALRDHQEQANTIFSLR 305
                  L+  + ELE   ++ KL + +  +Q+  E+ +     Q L++ Q    +  S +
Sbjct: 2469 DHDAERLREAIAELER--EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2526

Query: 306  KDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATRE 365
              L Q E    R +E+++          K  ++++D +       EE   ++ Q    R+
Sbjct: 2527 DSLLQRE----RFIEQEK---------AKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2573

Query: 366  ELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSS 425
             L A      + +    + VR   E+  +L+ Q  Q E +LLA E +  R+QL+ L    
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQRLREQLQLL---E 2629

Query: 426  DLEDGSPRRSQELSLPQDLEDTQL-SDKGCLAGGGS---PKQPFAALHQEQVLRNPHDAG 481
            +    +   S+E++  Q      L + +  L G  +   P+  F  L ++   +   +AG
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2689

Query: 482  LSSGE 486
            + S E
Sbjct: 2690 ILSAE 2694



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 104/465 (22%), Positives = 187/465 (40%), Gaps = 65/465 (13%)

Query: 98   EPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH 157
            E AR   + ++ +  S   +L        +K  Q L   L  +   + +LR +     + 
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQ 1643

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEE----KGAALMRNRDLQLEIDQL 213
            Q   +R +EE E   REL+R + +  + A+RL  Q+EE    K  A       + E ++ 
Sbjct: 1644 QAEAERAREEAE---RELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE 1699

Query: 214  KHSLMKAEDDCKVER-------------------------KHTLKLRHAMEQRPSQELLW 248
                 KAE+    +R                         +  ++LR   EQ   Q  L 
Sbjct: 1700 ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1759

Query: 249  E-----LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
            E     LQ+E A    + QELEA + + + +     ++VL     +A    +E++ +   
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAE-----MEVLLASKARA----EEESRSTSE 1810

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLA--LRKDSKMYKDRIEAILLQMEEVAIERDQAI 361
              K   + EA R R + E E   L+ LA   ++  ++ ++       + E V  E+  AI
Sbjct: 1811 KSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQ 417
                 L  +    L+EK+A  +++R L E    +   L+ Q  Q +A +     +LR+  
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929

Query: 418  LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAAL--HQEQVLR 475
               L     L + + R+ +++   +++   + S +   AG    +     +  + E  LR
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVE--EEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987

Query: 476  NPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEE 520
            +   A L      E  R+R   + E  RR+ A  ++QK     EE
Sbjct: 1988 SKEQAEL------EAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 85/405 (20%), Positives = 171/405 (42%), Gaps = 31/405 (7%)

Query: 117  QLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQR--LKEECEAGSRE 174
            Q L+ E+ +  +KV++         + IK+  ++    +   E V     K + ++GS  
Sbjct: 1279 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1338

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            +    +E  DL     H SE         + +   + +++     AE     ER+   ++
Sbjct: 1339 VI---QEYVDLR---THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392

Query: 235  RHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
              A+E++  ++L     Q KA  +   +EL+  +QE  + R             +A  D 
Sbjct: 1393 EAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE------------EAAVDA 1438

Query: 295  QEQANTIFSLRKDLRQGEARRLRCM-EEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
            Q+Q  +I    + LRQ     ++    + E  E   L + ++ ++ + ++EA   Q    
Sbjct: 1439 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1498

Query: 354  AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV---FQCEAQLLAVE 410
              E     A  EE  AQ  +  +E + LR+QV++  ++  + ++++    + EA+  A E
Sbjct: 1499 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE-AARE 1557

Query: 411  GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFA--AL 468
             +   Q LE L L ++  +   R+++     Q     + + +   A   S +  FA    
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617

Query: 469  HQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQK 513
              E+ L+  H A     E  E ERR  +++     R+ A R++++
Sbjct: 1618 QLERSLQEEHVAVAQLRE--EAERRAQQQAEAERAREEAERELER 1660



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 108/511 (21%), Positives = 202/511 (39%), Gaps = 75/511 (14%)

Query: 59   RKVGVLLDILQRTGHKGYVA------FLESLELYYPQLYKKVTGKEPARVFSMIIDASGE 112
            R+   LL+ ++R G K          ++ +++ Y  QL       EP  V S       +
Sbjct: 1276 RQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP--VASPAKKPKVQ 1333

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGS 172
            SG ++ ++ E + L+    +LT L S    FI E       LR+ +E  +RL E+  A  
Sbjct: 1334 SG-SESVIQEYVDLRTHYSELTTLTSQYIKFISET------LRRMEEE-ERLAEQQRAEE 1385

Query: 173  RELKRCKEENYDLAMRLAH-QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            RE     E   +   +LA   ++ K  A    ++LQ  + +      +A  D + +++  
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445

Query: 232  LKLRHAMEQRPSQELLWELQQEKALLQARVQ----------ELEASVQ-----EGKLDRS 276
             +    + Q    E+  + +Q +A  ++R++          +LEA+ +     EG+L   
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGE---ARRLRCMEEKEMFELQCLALR 333
                +  E   RQA  + +     +    +  RQ E   A R++   E    + + L   
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565

Query: 334  KDSKMYKDRIEAILLQME-------EVAIERDQAIATRE---------ELHAQHARGLQE 377
            ++ ++  +  E  L Q E       +VA+E  Q  A  E         E  AQ  R LQE
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
            +     Q+RE  E+  + Q +  +   +    E  L R QL+                  
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKA----------------N 1666

Query: 438  LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKE 497
             +L   L+  +++ +  LA   + KQ   A  + +      +  +   E  E+E  + ++
Sbjct: 1667 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726

Query: 498  SFENYRRKR-----ALRKMQKGWRQGEEDRE 523
              E   ++R      L +++    QGE+ R+
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 42/363 (11%)

Query: 158  QERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLK--- 214
            ++ + RL+ E E G ++ +  +EE       LA    E  AA  + ++L+ E+ +++   
Sbjct: 1739 EQELIRLRAETEQGEQQRQLLEEE-------LARLQREAAAATQKRQELEAELAKVRAEM 1791

Query: 215  HSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD 274
              L+ ++   + E + T        ++  Q L  E  + + L +     L A  +E K  
Sbjct: 1792 EVLLASKARAEEESRST-------SEKSKQRLEAEAGRFRELAE-EAARLRALAEEAKRQ 1843

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQC 329
            R     Q+ EED   A R   E    +    K    GEA RL+      ++EKE    + 
Sbjct: 1844 R-----QLAEED---AARQRAEAERVL--AEKLAAIGEATRLKTEAEIALKEKEAENERL 1893

Query: 330  LALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG 389
              L +D    + R+E    Q +    ER   +    +   +  +GL E D LR Q R++ 
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVE-DTLR-QRRQVE 1951

Query: 390  EKADELQLQVFQCEAQLLAVE---GRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD--- 443
            E+   L+    +  A    +E   GR+R    +TL  S +  +    R ++L+  ++   
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTL-RSKEQAELEAARQRQLAAEEERRR 2010

Query: 444  LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             E  +   K   A   + +Q  AAL + + L+   +      E  E+E  R  +  +   
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070

Query: 504  RKR 506
            +KR
Sbjct: 2071 QKR 2073



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/356 (21%), Positives = 150/356 (42%), Gaps = 56/356 (15%)

Query: 98   EPARVFSMIIDASGESGLTQLLM-TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRK 156
            E  RV +  + A GE+  T+L    E+   +K+ ++      ++D+  +  R+++   + 
Sbjct: 1857 EAERVLAEKLAAIGEA--TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1914

Query: 157  HQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRN--------RDLQL 208
              +  +RL +  +A   EL+R K    D  +R   Q EE+  AL  +         +L+L
Sbjct: 1915 KADIEERLAQLRKASDSELERQKGLVED-TLRQRRQVEEEILALKASFEKAAAGKAELEL 1973

Query: 209  EIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASV 268
            E+ +++ +   AED  + + +  L+   A  QR   +L  E ++ +   + RVQ+  A+ 
Sbjct: 1974 ELGRIRSN---AEDTLRSKEQAELE---AARQR---QLAAEEERRRREAEERVQKSLAAE 2024

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            +E    R +   +V      + L+   E+A     LR+   Q  AR+L+  +E     LQ
Sbjct: 2025 EEAARQRKAALEEV------ERLKAKVEEARR---LRERAEQESARQLQLAQEAAQKRLQ 2075

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
                       +++  A  +Q +E  +++                 LQ++ ++  Q+R  
Sbjct: 2076 A----------EEKAHAFAVQQKEQELQQT----------------LQQEQSVLDQLRGE 2109

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             E A     +  +   Q      + RRQ  E   L    E+ +  R+Q  +  + L
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 104/442 (23%), Positives = 191/442 (43%), Gaps = 56/442 (12%)

Query: 122 EVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQE-RVQRLKEECEAGSRELKRCKE 180
           E  +LQ++++    L   +++  ++L  ++   R  QE R QRLK E E    +L + +E
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583

Query: 181 ENYDLAMRLAHQSEEKGAALMRNRDLQ-LEIDQLKHSLMKAEDDCKVERKHTLKLRHAME 239
           E      RL  + EE+    ++  +++ LE ++ +   +K E+  +  R+  LK     E
Sbjct: 584 ERRQ--QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 240 QRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQAN 299
           +R  Q+ L   QQE+     R Q L+   +E +L++        E   ++   + QEQA 
Sbjct: 642 RR--QQQLRREQQER-----REQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694

Query: 300 TIFSLR-----------KDLRQGEA----------RRLRCMEEKEMFELQCLALRKDSKM 338
                R            D RQ +           RR +  EEK       L  +++ + 
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754

Query: 339 YKDRIE-------AILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEK 391
           ++ + E           Q EE +    Q ++ R  L  Q  R L+ ++  +++ R L E+
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814

Query: 392 ADE----LQLQVFQCEAQLLAVEGRL-RRQQLETLVLSSD--LEDGSPRRSQELSLPQ-- 442
            ++     Q +  + E Q L  E +L RR++ + L    D   ED   RRSQE    Q  
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874

Query: 443 --DLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFE 500
              LE+ +   +  L    + ++    L +EQ L    +  L   +  E+E+RR +E   
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQE---QLRKEQQLLQEEEEEL---QREEREKRRRQEQER 928

Query: 501 NYRRKRALRKMQKGWRQGEEDR 522
            YR +  L++ ++   + E ++
Sbjct: 929 QYREEEQLQQEEEQLLREEREK 950



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 97/409 (23%), Positives = 175/409 (42%), Gaps = 56/409 (13%)

Query: 131 QDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLA 190
           ++  A    K+  +++ R ++   R+ + R ++L+EE   G R  ++ +E+  +LA    
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQ-RRFEPRDRQLEEE--PGQRRRQKRQEQERELAEG-E 152

Query: 191 HQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLR-HAMEQRPSQELLWE 249
            QSE++     R+R  + E    +    +  ++ + E +     + H  E+ P +E L  
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL-- 210

Query: 250 LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQ---ALRDHQEQANTIFSLRK 306
             + + LL+ R +  E   Q+ +  +   + +  E++WR+    LR  +E+       R+
Sbjct: 211 --RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268

Query: 307 DLRQGEARRLRCMEEKEMF------ELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA 360
              Q E  +LR +E +E+       E Q   LR++ ++ + + E    Q EE   E+ + 
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR-EQQER 327

Query: 361 IATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEA---QLLAVEGRLRRQQ 417
              +EE   Q  R  QE+   ++  RE  E+  E QL+  Q E    Q L  E +LRR+Q
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387

Query: 418 LETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNP 477
                          RR Q+L   Q L   Q                   L +EQ LR  
Sbjct: 388 -------------QLRREQQLRREQQLRREQ------------------QLRREQQLRRE 416

Query: 478 HDAGLSSGEPPEKERRRLKESFENYRRKRALRKMQ---KGWRQGEEDRE 523
                      E+E  R ++  E  RR++ L++ Q   + W + EE+ E
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 93/395 (23%), Positives = 174/395 (44%), Gaps = 62/395 (15%)

Query: 147 LRVKDSLLRKHQER-VQRLKEECEAGSRELKRCKEENYDLAMRL-------AHQSEEKGA 198
           L++++   R+ QER  Q+L+ E E    +  + +EE   L  RL         Q E +  
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 199 ALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQ 258
            L R  + +LE ++ +  L + ++    ER+  L  R   E+R  Q L  E Q+E+   +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQE----ERRDQLLKRE--EERRQQRLKRE-QEERLEQR 601

Query: 259 ARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRC 318
            + +E+E   QE + ++     +  EE  +Q L+  +++      LR++ ++   +RL+ 
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661

Query: 319 MEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEK 378
            EE+E  E +                   L+ E     R+Q +A  E+  A+     + K
Sbjct: 662 EEEEERLEQR-------------------LKREHEEERREQELAEEEQEQARE----RIK 698

Query: 379 DALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE------TLVLSSDLEDGSP 432
             + K   +L  +AD  Q +V+   ++    EG+ RRQ+ E         L    E+ + 
Sbjct: 699 SRIPKWQWQLESEADARQSKVY---SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755

Query: 433 RRSQELSLPQDL----EDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPP 488
           R+ QE    +D     +  + S++G        +Q  +A      LR   +  L + E  
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERG--------RQRLSA---RPPLREQRERQLRAEERQ 804

Query: 489 EKERRRLKESFENYRRKRALRKMQKGWRQGEEDRE 523
           ++E+R L E  E  +R+R  R+ +K  +  EE+ +
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 89/389 (22%), Positives = 172/389 (44%), Gaps = 44/389 (11%)

Query: 145 KELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLA----HQSEEKGAAL 200
           ++LR +  L R+ +E     K E E   + LKR +EE  D   R      H+ E +   L
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476

Query: 201 MRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQAR 260
            R+++ +     LK   ++ E+  + + +   +LR   E+R  Q L  + Q+E+  LQ R
Sbjct: 477 KRDQEEERRERWLK---LEEEERREQQERREQQLRREQEERREQRL--KRQEEEERLQQR 531

Query: 261 VQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCME 320
           ++    S Q+ + ++     Q+L+ +  + L   + +       ++  R+ E RR + ++
Sbjct: 532 LR----SEQQLRREQEERREQLLKREEEKRLEQERRE-------QRLKREQEERRDQLLK 580

Query: 321 EKEMFELQCLALRKDSKMYK--DRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEK 378
            +E    Q L   ++ ++ +   R E   L+ EE   +R +     EE   Q  +  +++
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640

Query: 379 DALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQEL 438
           +  ++Q+R   ++  E +L+  + E +L   E RL+R+  E             RR QEL
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERL---EQRLKREHEE------------ERREQEL 685

Query: 439 SLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPH-DAGLSSGEPPEKERRRLKE 497
           +  ++ E  +   K  +       +  A   Q +V   P    G    +  E++RRR + 
Sbjct: 686 A-EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744

Query: 498 SFENYRRKRALRKMQKGWRQGEEDRENTT 526
             +    +RA R+ Q+     EE R + T
Sbjct: 745 ELQWQEEERAHRQQQE-----EEQRRDFT 768



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 91/394 (23%), Positives = 171/394 (43%), Gaps = 38/394 (9%)

Query: 156  KHQERVQRLKEECEA--GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQL 213
            + +ER Q+L+EE +     +E +R +E+  D   R   + E K           L+    
Sbjct: 841  QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 214  KHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQA-----RVQELEASV 268
            K   +  E++ +++R+   K R   ++R  +E     Q+E+ LL+      R QE E   
Sbjct: 901  KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960

Query: 269  QEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ 328
            ++ K  +     Q+L E+  +  R  +E+    +   ++L+Q E + LR   EK   +  
Sbjct: 961  RKDKKLQQKEE-QLLGEEPEKRRRQEREKK---YREEEELQQEEEQLLREEREKRRRQEW 1016

Query: 329  CLALRKDSKMYKDRIEAILLQMEEVAI-ERDQAIATREELHAQHARGL-QEKDALRKQVR 386
                RK  ++ ++  + +  + E+  + ER++     EEL  +  + L +E++  R+Q  
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 387  ELG-EKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSD-----------LEDGSPRR 434
            E    K +ELQ    Q E QLL  E   RR+Q        +            E+   RR
Sbjct: 1077 ERQYRKEEELQ----QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132

Query: 435  SQELSLP-QDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPP---EK 490
             QEL    ++ E+ Q  ++  L      ++P     QE   +   +  L   E     E+
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLR-----EEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 491  ERRRLKESFENYRRKRALRKMQKGWRQGEEDREN 524
            + +R +E    YR +  L++ ++  R  +ED+ +
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 101/430 (23%), Positives = 176/430 (40%), Gaps = 43/430 (10%)

Query: 118 LLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQE---RVQRLKEECEAGSRE 174
           +L  E  KLQ++       L  +++ +++L  +  L R+ QE   + QRL+ E     ++
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLE-RQELRRERQEEEQQQQRLRRE-----QQ 305

Query: 175 LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
           L+R +EE          + +E+       R+ QL  +Q +    +   + + ER+     
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365

Query: 235 RHAMEQRPSQELLWELQQEKALLQARVQELEASVQ---EGKLDRSSPYIQVLEEDWRQAL 291
           R   E+R  Q+L  E Q  +     R Q+L    Q   E +L R     +  +    Q L
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425

Query: 292 RDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQME 351
           R  QE+        +   + E R  R   E+E         R+D    ++  E    +  
Sbjct: 426 RREQEEER-----HEQKHEQERREQRLKREQEE--------RRDWLKREEETERHEQERR 472

Query: 352 EVAIERDQAIATREE-LHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQL---L 407
           +  ++RDQ    RE  L  +     ++++   +Q+R   E+  E +L+  + E +L   L
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532

Query: 408 AVEGRLRRQQLE----TLVLSSDLEDGSPRRSQELSLPQDLEDTQL-----SDKGCLAGG 458
             E +LRR+Q E     L    +      RR Q L   Q+    QL       +      
Sbjct: 533 RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592

Query: 459 GSPKQPFAALHQEQVLRNPHDAGLS---SGEPPEKERRR--LKESFENYRRKRALRKMQK 513
              ++    L +E+V R   +         E PE+ERR+  LK   +  RR++ LR+ Q+
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 514 GWRQGEEDRE 523
             R+    RE
Sbjct: 653 ERREQRLKRE 662



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 96/443 (21%), Positives = 178/443 (40%), Gaps = 66/443 (14%)

Query: 124  MKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCK--EE 181
            ++ Q++ Q L      + D  ++ R ++  L + QER ++ +EE +   R+ +  K  EE
Sbjct: 1399 LRCQEREQQL------RQDRDRKFREEEQQLSR-QERDRKFREEEQQVRRQERERKFLEE 1451

Query: 182  NYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCK-VERKHTLKLRHAMEQ 240
               L      +  E+   L    + QL   +     ++ E   +  ER    + +    Q
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511

Query: 241  RPSQELLWELQQ-------EKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRD 293
             P ++ L E QQ        K L + +    +   Q+ + DR   + +  EE  RQ   +
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE--EEQLRQEREE 1569

Query: 294  HQ---EQANTIFSLRKDLRQGEARRLRCMEEKEMFELQ----CLALRKDSKMYKDRIEAI 346
             Q   ++ +  F L +   + + +  + ME+++    Q     L   +D K  +D  E +
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED--EQL 1627

Query: 347  LLQMEEVAI---ERDQAIATRE--------ELHAQHARGLQ-----------EKDALRKQ 384
            L + EE  +   ERD+     E        E   +H R  +           E+  LR+Q
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687

Query: 385  VRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDL 444
             R+   + +E QL+  + E + L  E +LRRQ+LE             +  +E  L Q+ 
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER------------KFREEEQLRQET 1735

Query: 445  EDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERR----RLKESFE 500
            E  QL  +         +Q      ++Q+ R   D      E   +ER     R +ES  
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795

Query: 501  NYRRKRALRKMQKGWRQGEEDRE 523
             +R +  LR+ ++  +   + R+
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRD 1818



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 102/455 (22%), Positives = 177/455 (38%), Gaps = 67/455 (14%)

Query: 137  LSSKDDFIKELRVKDSLLRKHQERVQR------LKEECEAGSRELKRCKEENYDLAM--R 188
            L +K    ++LR +  LL++ +E +QR       ++E E   RE ++ ++E   L    R
Sbjct: 889  LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948

Query: 189  LAHQSEEKGAALMRNRDLQLEIDQL----------KHSLMKAEDDCKVERKHTLKLRHAM 238
               + +E+     +++ LQ + +QL          +    K  ++ +++++    LR   
Sbjct: 949  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008

Query: 239  EQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQA 298
            E+R  QE  WE Q  K       QE E  ++E   +R    +Q  E  +R+     QE+ 
Sbjct: 1009 EKRRRQE--WERQYRKK--DELQQEEEQLLRE---EREKRRLQERERQYREEEELQQEEE 1061

Query: 299  NTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERD 358
              +   R+  R+ E  R    EE+   E + L   +  K  +   E    + EE+  E +
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121

Query: 359  QAI------ATREELHAQHARGLQEKDALRKQVRELGEKADELQL--------QVFQCEA 404
            Q +        R+EL  Q+    + +    + +RE  EK    +L        ++ Q E 
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181

Query: 405  QLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQ--------ELSLPQDLEDTQLSDKGCLA 456
            QLL  E   RRQ+ E      +      R+ +        +L    + E         + 
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241

Query: 457  GGGSPKQPFAALHQEQVLRN-------PHDAGLSSGEPPEKERRRL---------KESFE 500
              G   + F  L   Q LR+        H  G       E+ERRR          +E  E
Sbjct: 1242 CKGRENEQFRQLEDSQ-LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLE 1300

Query: 501  NYRRKRALRKMQKGWRQGE---EDRENTTGSDNTD 532
               +K A R+ +K   + +   E+RE       TD
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 94/399 (23%), Positives = 166/399 (41%), Gaps = 41/399 (10%)

Query: 150  KDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQS--EEKGAALMRNRDLQ 207
            ++ LLR  +ER +R ++E E   RE +  ++E   L      +   +E         +LQ
Sbjct: 1120 EEQLLR--EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177

Query: 208  LEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEAS 267
             E +QL   L + ++  + ER+   +    ++++  ++   +  Q   L      E E +
Sbjct: 1178 QEEEQL---LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234

Query: 268  VQEGKL---DRSSPYIQVLEEDWRQALRDHQEQANTIFSL-------RKDLRQGEARRLR 317
            V++ K+    R +   + LE+     LRD Q Q +    L       R+  R+   +R R
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDS---QLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR 1291

Query: 318  CMEEKEMFEL--QCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGL 375
               E+E  E   Q  A R+D K  +++ + +  + EE    ++     REE      R  
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEK-QLLREEREEKRRRQETDRKFREEEQLLQER-- 1348

Query: 376  QEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRS 435
             E+  LR+Q R+   + +EL+ Q  +   + L  E RLRRQ+ E   L  + +     R 
Sbjct: 1349 -EEQPLRRQERDRKFREEELRHQ--EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405

Query: 436  QELSLPQDL----EDTQLSDKGCLAGGGSPKQPFAA-------LHQEQVLRNPHDAGLSS 484
            Q+L   +D     E+ QLS +         +Q           L +EQ LR         
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465

Query: 485  GEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDRE 523
             E   +ER   ++      R R   + ++  R+ E DR+
Sbjct: 1466 EEQLLQERE--EQQLHRQERDRKFLEEEQQLRRQERDRK 1502



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 83/402 (20%), Positives = 167/402 (41%), Gaps = 61/402 (15%)

Query: 128  KKVQDLTALLSSKDDFIKELRVKDSLLR----KHQERVQRLKEECEAGSRELKRCKEENY 183
            +K ++   LL  +++     + +D   R    +HQE+ ++  EE     + L+R + E  
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE----EQRLRRQERERK 1391

Query: 184  DLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPS 243
             L      + +E+   L ++RD +   ++    L + E D K  R+   ++R    +R  
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEE--QQLSRQERDRKF-REEEQQVRRQERERKF 1448

Query: 244  QELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
             E   +L+QE+       ++L    +E +L R     + LEE+  Q LR  +        
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE--QQLRRQERD------ 1500

Query: 304  LRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIAT 363
                 R+   + LR  E +  F      L ++ ++++ + +   LQ E+           
Sbjct: 1501 -----RKFREQELRSQEPERKF------LEEEQQLHRQQRQRKFLQEEQ---------QL 1540

Query: 364  REELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVL 423
            R +   Q  R  Q++D   ++  +L ++ +E QL   + + +    E ++RRQ+ E   +
Sbjct: 1541 RRQERGQQRR--QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598

Query: 424  SSDLEDGSPRRSQELSLPQD---LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDA 480
              + +       Q+L   +D    ED QL  +                 ++Q+ R   D 
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQE---------------REEQQLHRQERDR 1643

Query: 481  GLSSGEPPEKERRRLKESFENYRRKRALRKMQKGWRQGEEDR 522
                 EP  + RR+ +E    + R R  R+ ++  ++GEE +
Sbjct: 1644 KFLEEEP--QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 83/380 (21%), Positives = 157/380 (41%), Gaps = 56/380 (14%)

Query: 148  RVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAH----QSEEKGAALMRN 203
            R ++   R+ ++  +R + E E   +E +R   +  +   R       Q+EEK     + 
Sbjct: 724  RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783

Query: 204  RDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQR--PSQELLWELQQEKALLQARV 261
               +  + + +   ++AE+            R   EQR  P +E   E +Q +   + R 
Sbjct: 784  LSARPPLREQRERQLRAEE------------RQQREQRFLPEEE---EKEQRRRQRRERE 828

Query: 262  QELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKD-----LRQGEARRL 316
            +EL+   +E +L R     Q+ EE+    L++ QE+  +    R       L +   RR 
Sbjct: 829  KELQFLEEEEQLQRRERAQQLQEEE--DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886

Query: 317  RCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGL- 375
              +  K   + Q   LRK+ ++ ++  E +  +  E    ++Q    REE   Q      
Sbjct: 887  HTLYAKPALQEQ---LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943

Query: 376  --QEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPR 433
              +E++  R+Q RE   + D+   ++ Q E QLL  E   RR+Q          E+   +
Sbjct: 944  LREEREKRRRQERERQYRKDK---KLQQKEEQLLGEEPEKRRRQERE---KKYREEEELQ 997

Query: 434  RSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERR 493
            + +E  L ++ E  +  +          K+      +EQ+LR             E+E+R
Sbjct: 998  QEEEQLLREEREKRRRQE----WERQYRKKDELQQEEEQLLRE------------EREKR 1041

Query: 494  RLKESFENYRRKRALRKMQK 513
            RL+E    YR +  L++ ++
Sbjct: 1042 RLQERERQYREEEELQQEEE 1061



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 73/306 (23%), Positives = 132/306 (43%), Gaps = 35/306 (11%)

Query: 145  KELRVKDSLLRKHQERVQRLKEE----CEAGSRELKRCKEENYDLAMRLAHQSEEKGAAL 200
            ++LR ++   +  QER ++ +E+     E   ++L R + +   L      + +E+   L
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661

Query: 201  MRNRDLQL-EIDQL-----KHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEK 254
              +RD +  E +QL     +  L + E D K   +     R   E++  QE     +QE 
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721

Query: 255  ALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQE----QANTIFSLRKDLRQ 310
                   ++L    ++ +L R   Y ++LEE+  +  R+ Q+    + +  F   + LRQ
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ 1781

Query: 311  G-EARRLRCMEEKEMF--------ELQCLALRKDSKMYKDRIEAILLQMEE----VAIER 357
              E ++LR  E    F        E +   LR   +  K R E   LQ+EE    +  ER
Sbjct: 1782 EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER 1841

Query: 358  D------QAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEG 411
            D      +  AT+E+   +     QE++  R+Q RE   + + ++ Q  Q E Q     G
Sbjct: 1842 DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ--QKEEQRHRQVG 1899

Query: 412  RLRRQQ 417
             ++ Q+
Sbjct: 1900 EIKSQE 1905


>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
           b [Homo sapiens]
          Length = 882

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/364 (21%), Positives = 161/364 (44%), Gaps = 34/364 (9%)

Query: 119 LMTEVMKLQKKVQDLTALLSSKDDFIKELRVK----DSLLRKHQERVQRLKEE---CEAG 171
           ++ E  + QK++ ++   +S +DD I+ELR K    ++L+ + ++ + +L+ +   C A 
Sbjct: 86  MIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTAT 145

Query: 172 SRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            R      EE  D+   L H  E+K +  +   + Q  +  L+  L    +  +   K  
Sbjct: 146 HRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDM 205

Query: 232 LKLR---HAMEQRPSQELLWELQQEKALLQARVQELEASVQE-GKLD-RSSPYIQVLEED 286
           +KL    H + +  S   +    ++  +LQ R+QEL+    E  KL  +   ++Q  +E 
Sbjct: 206 MKLELDLHGLREETSAH-IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 264

Query: 287 WRQALRDHQEQANTIFSLRKDLRQGEA------RRLRCMEEKEMFELQCLALRKDSKMYK 340
            ++  +   +  N++    K+L + +         ++  ++ +  E +C AL+ + +  K
Sbjct: 265 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLK 324

Query: 341 DRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQ---- 396
           + +E    Q E +A ++         L   H    Q K  L+K +    +KAD +Q    
Sbjct: 325 NSLEE-AKQQERLAAQQAAQCKEEAALAGCHLEDTQRK--LQKGLLLDKQKADTIQELQR 381

Query: 397 -LQVFQCEAQLLAVEGRLRRQQLETLVL-------SSDLEDGSPRRSQELSLPQDLEDTQ 448
            LQ+ Q E+ +   E    R+++E L L         +  D   R+ Q+    QD++   
Sbjct: 382 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 441

Query: 449 LSDK 452
           + D+
Sbjct: 442 MLDR 445



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 40/300 (13%)

Query: 127 QKKVQDLTALLSSKDDFIKELRVK-DSLLRKHQERVQRL--KEECEAGSRELKRCKEENY 183
           Q+ +QDL   ++ + + +  L+ + D  L+K +  +Q    KE  +A SR+   C+++  
Sbjct: 542 QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLT 601

Query: 184 DLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLR-------- 235
               +L H + E  +        Q +  QL+  ++  E+  K       KLR        
Sbjct: 602 QALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESEL 661

Query: 236 --HA----MEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQ 289
             HA    +E+   Q L W+ Q +  L     +  E  ++E + + ++    +LE+D   
Sbjct: 662 EVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAK--EEQLREFQEEMAALKENLLEDDKEP 719

Query: 290 ALRDHQEQANTIFSLRKD---LRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAI 346
                       +S+ KD   L +G  + +  +E  +  + Q +A  K     +++++ I
Sbjct: 720 CCLPQ-------WSVPKDTCRLYRGNDQIMTNLE--QWAKQQKVANEKLGNQLREQVKYI 770

Query: 347 LLQMEEVAIERDQAIA---------TREELHAQHARGLQEKDALRKQVRELGEKADELQL 397
                E   E  +A +         +   LH+      QE   L+K++ E   KA+  +L
Sbjct: 771 AKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 830


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
           a [Homo sapiens]
          Length = 1007

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/364 (21%), Positives = 161/364 (44%), Gaps = 34/364 (9%)

Query: 119 LMTEVMKLQKKVQDLTALLSSKDDFIKELRVK----DSLLRKHQERVQRLKEE---CEAG 171
           ++ E  + QK++ ++   +S +DD I+ELR K    ++L+ + ++ + +L+ +   C A 
Sbjct: 231 MIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTAT 290

Query: 172 SRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHT 231
            R      EE  D+   L H  E+K +  +   + Q  +  L+  L    +  +   K  
Sbjct: 291 HRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDM 350

Query: 232 LKLR---HAMEQRPSQELLWELQQEKALLQARVQELEASVQE-GKLD-RSSPYIQVLEED 286
           +KL    H + +  S   +    ++  +LQ R+QEL+    E  KL  +   ++Q  +E 
Sbjct: 351 MKLELDLHGLREETSAH-IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 409

Query: 287 WRQALRDHQEQANTIFSLRKDLRQGEA------RRLRCMEEKEMFELQCLALRKDSKMYK 340
            ++  +   +  N++    K+L + +         ++  ++ +  E +C AL+ + +  K
Sbjct: 410 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLK 469

Query: 341 DRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQ---- 396
           + +E    Q E +A ++         L   H    Q K  L+K +    +KAD +Q    
Sbjct: 470 NSLEE-AKQQERLAAQQAAQCKEEAALAGCHLEDTQRK--LQKGLLLDKQKADTIQELQR 526

Query: 397 -LQVFQCEAQLLAVEGRLRRQQLETLVL-------SSDLEDGSPRRSQELSLPQDLEDTQ 448
            LQ+ Q E+ +   E    R+++E L L         +  D   R+ Q+    QD++   
Sbjct: 527 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 586

Query: 449 LSDK 452
           + D+
Sbjct: 587 MLDR 590



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 54/284 (19%), Positives = 120/284 (42%), Gaps = 28/284 (9%)

Query: 127 QKKVQDLTALLSSKDDFIKELRVK-DSLLRKHQERVQRL--KEECEAGSRELKRCKEENY 183
           Q+ +QDL   ++ + + +  L+ + D  L+K +  +Q    KE  +A SR+   C+++  
Sbjct: 687 QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLT 746

Query: 184 DLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPS 243
               +L H + E        + LQ  + Q +    + E++     +   KL    E R  
Sbjct: 747 QALEKLNHVTSE-------TKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN--TELRKL 797

Query: 244 QELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS 303
           +    E + E      +++E+   V + +    +    +  ++  + LR+ QE+   + +
Sbjct: 798 RGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE--EQLREFQEE---MAA 852

Query: 304 LRKDLRQGEARRLRCMEEKEMFELQCLALRKD----------SKMYKDRIEAILLQMEEV 353
           L+++L + + +   C+ +  + +  C   R +          +K  K   E +  Q+ E 
Sbjct: 853 LKENLLEDD-KEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQ 911

Query: 354 AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQL 397
                +    ++ LH+      QE   L+K++ E   KA+  +L
Sbjct: 912 VKYIAKLSGEKDHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 955


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 81/373 (21%), Positives = 170/373 (45%), Gaps = 42/373 (11%)

Query: 114  GLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKEL-----RVKDSLLRKHQERVQR----- 163
            G ++ L   V +LQ++++DL    +   + +K+      +++++L+   +E  +      
Sbjct: 836  GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895

Query: 164  -LKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAE- 221
             L+ E EA    L +  +E   L+ +L  +SE+K        +++ E   L  ++ K + 
Sbjct: 896  ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK 955

Query: 222  ---DDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLD--RS 276
               D  +  R  TL+L++ +++   +      ++E A +Q +++E     ++ +L   + 
Sbjct: 956  EMADIVEASRTSTLELQNQLDEYKEKN-----RRELAEMQRQLKEKTLEAEKSRLTAMKM 1010

Query: 277  SPYIQVLEEDWR-------QALRDHQEQANTIFSL------RKDLRQGEARRLRCMEEK- 322
               ++++EE+ R       +AL   Q    T+  L      +  L+   +R ++ ME+K 
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKV 1070

Query: 323  EMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQH-ARGLQEKDAL 381
               E++    R +S +  +RI     QME++  E  Q  A R++L     +   Q KD  
Sbjct: 1071 SQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLK 1130

Query: 382  RKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLE--TLVLSSDLEDGSPRRSQELS 439
             + +   G      +  V Q EA++  +E RL  ++ +   L LS+   +   R+ +EL 
Sbjct: 1131 SRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLE---RKVKELV 1187

Query: 440  LPQDLEDTQLSDK 452
            +  D E   L+D+
Sbjct: 1188 MQVDDEHLSLTDQ 1200



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 70/340 (20%), Positives = 138/340 (40%), Gaps = 28/340 (8%)

Query: 129 KVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMR 188
           +V+DL    S     + EL+ +  L  K+Q+ ++  +E   A   EL+    E  +    
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENST 667

Query: 189 LAHQSEEKGAALMRNRD--LQLEIDQLKHSL-MKAEDDCKVERKHTLKLRHAMEQRPSQE 245
           L  + EE    L +N +   Q+++++ +H   ++   D   E    L      E R    
Sbjct: 668 LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGA 727

Query: 246 LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLR 305
           L+ EL Q K  LQ  +  +    QE  L +    +  L+   ++ +  H ++ + +    
Sbjct: 728 LIEELLQAKQDLQDLL--IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKL---- 781

Query: 306 KDLRQGEARRLRCMEEKEMFELQCLALRKDS------------KMYKDRIEAILLQMEEV 353
           K+    E + LR   E+    ++ LA R ++            K+ ++  E +  + EE+
Sbjct: 782 KEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEEL 841

Query: 354 AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQC-------EAQL 406
                Q     E+L    A+  +       ++R+L E     + +  +        E +L
Sbjct: 842 ERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901

Query: 407 LAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLED 446
            A +G L +   E   LS  L++ S ++ Q   L  ++E+
Sbjct: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941



 Score = 36.6 bits (83), Expect = 0.059
 Identities = 47/213 (22%), Positives = 94/213 (44%), Gaps = 30/213 (14%)

Query: 113  SGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH--QERVQRLKEECEA 170
            S L + +  +V +L+ ++++         + I   R +   LR    QER  R   EC+ 
Sbjct: 1060 SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDK 1119

Query: 171  GSRELKRCKEENYDLAMRLAH-----QSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCK 225
             S E      +N DL  R+ H     +S ++G  +     ++  I +L+  L   E D  
Sbjct: 1120 ISLE-----RQNKDLKSRIIHLEGSYRSSKEGLVVQ----MEARIAELEDRLESEERD-- 1168

Query: 226  VERKHTLKLRHAMEQRPSQELLWELQQE-------KALLQARVQELEASVQEGK--LDRS 276
               +  L+L +   +R  +EL+ ++  E       K  L  R++ ++  V+E +  +DR 
Sbjct: 1169 ---RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRL 1225

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLR 309
                + L+ +  + +  ++     + S++KDLR
Sbjct: 1226 ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 48/230 (20%), Positives = 100/230 (43%), Gaps = 35/230 (15%)

Query: 319 MEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEK 378
           +E+K    ++   L++       +++  +   + +  ER++  A  EEL +QH   ++E 
Sbjct: 613 LEQKSKLTIEVAELQR-------QLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN 665

Query: 379 DALRKQVREL-GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQE 437
             L++++ E  GE    L+ ++FQ + +    +  +R  Q +   +  +L+  S +RS++
Sbjct: 666 STLQQRLEESEGELRKNLE-ELFQVKMEREQHQTEIRDLQDQLSEMHDELD--SAKRSED 722

Query: 438 ----------LSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEP 487
                     L   QDL+D  ++ +         +Q      +E+ L     A       
Sbjct: 723 REKGALIEELLQAKQDLQDLLIAKE---------EQEDLLRKRERELTALKGALKEEVSS 773

Query: 488 PEKERRRLKESFENYRRKRALRKMQKGWRQGEE---DRENTTGSDNTDTE 534
            ++E  +LKE ++     +ALR+  +   +  E    R NT+  D   TE
Sbjct: 774 HDQEMDKLKEQYD--AELQALRESVEEATKNVEVLASRSNTSEQDQAGTE 821


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 69/303 (22%), Positives = 135/303 (44%), Gaps = 54/303 (17%)

Query: 122  EVMKLQKKVQDLTALL----SSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKR 177
            ++ KLQ +++D    L    +S+++ + + +  +  L+  +  + +L+EE  A  R  ++
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698

Query: 178  CKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAED--------------- 222
             ++E  +LA  +A+ S +   AL   R L+  I QL+  L + +                
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758

Query: 223  ------DCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRS 276
                  D  +ER H  K  +A +Q         L+++   L+ ++QE+E +V+     + 
Sbjct: 1759 IDQINTDLNLERSHAQKNENARQQ---------LERQNKELKVKLQEMEGTVKS----KY 1805

Query: 277  SPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEK-EMFELQCLALRKD 335
               I  LE    Q     +EQ +         RQ   +++R  E+K +   LQ    R++
Sbjct: 1806 KASITALEAKIAQL----EEQLDN----ETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857

Query: 336  SKMYKD-------RIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
            ++ YKD       R++ +  Q+EE   E  +A A+R +L  +     +  DA+ ++V  L
Sbjct: 1858 AEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSL 1917

Query: 389  GEK 391
              K
Sbjct: 1918 KNK 1920



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 74/332 (22%), Positives = 147/332 (44%), Gaps = 44/332 (13%)

Query: 115  LTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVK----DSLLRKHQERVQRLKEECEA 170
            L   LM E ++LQ+++Q  T L +  ++    L  K    + +    + RV+  +E C+ 
Sbjct: 874  LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933

Query: 171  GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKH 230
               E K+ ++   +L  +L    EE+ A     + LQLE    +  L K E+        
Sbjct: 934  LQAEKKKMQQNIQELEEQL---EEEESA----RQKLQLEKVTTEAKLKKLEE-------- 978

Query: 231  TLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGK-----LDRSSPYIQVLEE 285
                    EQ   ++   +L +EK LL+ R+ E   ++ E +     L +     + +  
Sbjct: 979  --------EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030

Query: 286  DWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEA 345
            D  + LR  ++Q   +   R+ L +G++  L   ++    + Q   L+      ++ ++A
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKL-EGDSTDL--SDQIAELQAQIAELKMQLAKKEEELQA 1087

Query: 346  ILLQMEEVAIERDQAIATREELHAQHARGLQE--------KDALRKQVRELGEKADELQL 397
             L ++EE A +++ A+    EL +Q +  LQE        ++   KQ R+LGE+ + L+ 
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERASRNKAEKQKRDLGEELEALKT 1146

Query: 398  QVFQCEAQLLAVEGRLRRQQLETLVLSSDLED 429
            ++        A +    +++ E  +L   LE+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 69/305 (22%), Positives = 133/305 (43%), Gaps = 41/305 (13%)

Query: 160  RVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMK 219
            +V R +EE  A   EL + +E+      RL      +   +     LQ ++        +
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898

Query: 220  AED---DCKVERKHTLKLRHAMEQR--PSQELLWELQQEKALLQARVQELEASVQEGKLD 274
            AE+       +++   ++ H +E R    +E    LQ EK  +Q  +QELE  ++E    
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE---- 954

Query: 275  RSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRK 334
                     EE  RQ L+   E+  T           EA+  +  EE+ + E Q   L K
Sbjct: 955  ---------EESARQKLQ--LEKVTT-----------EAKLKKLEEEQIILEDQNCKLAK 992

Query: 335  DSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQE--------KDALRKQVR 386
            + K+ +DRI      + E   E+ +++A  +  H      L+E        +  L K  R
Sbjct: 993  EKKLLEDRIAEFTTNLTEEE-EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051

Query: 387  ELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLED 446
            +L   + +L  Q+ + +AQ+  ++ +L +++ E     + +E+ + +++  L   ++LE 
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE- 1110

Query: 447  TQLSD 451
            +Q+S+
Sbjct: 1111 SQISE 1115



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 77/322 (23%), Positives = 141/322 (43%), Gaps = 30/322 (9%)

Query: 145  KELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEE---NYDLAMRLAHQSEEKGAALM 201
            +E   K   L +  E     K E E  +++ +   E+   + D   +  H+ E+   AL 
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531

Query: 202  RN-RDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWELQQEKALLQAR 260
            +   +++ ++++L+  L +A +D K+  +  L+   A  +R  Q    + +++K  L  +
Sbjct: 1532 QQVEEMKTQLEELEDEL-QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590

Query: 261  VQELEASVQEGKLDRSSPYI--QVLEEDWRQALRDHQEQAN-TIFSLRKDLRQGEARRLR 317
            V+E+EA +++ +  RS      + LE D +  L  H + AN       K LR+ +A+   
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKD-LEAHIDSANKNRDEAIKQLRKLQAQMKD 1649

Query: 318  CMEEKE-----MFELQCLALRKDSKMYKDRIEAILLQMEEVAIERD--QAIATREEL--- 367
            CM E +       E+   A   + K+     E I LQ E  A ER   QA   R+EL   
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709

Query: 368  ----HAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVL 423
                  + A  L+EK  L  ++ +L E+ +E Q            +  RL++  L+   +
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQ-------GNTELINDRLKKANLQIDQI 1762

Query: 424  SSDLEDGSPRRSQELSLPQDLE 445
            ++DL        +  +  Q LE
Sbjct: 1763 NTDLNLERSHAQKNENARQQLE 1784



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 96/476 (20%), Positives = 197/476 (41%), Gaps = 68/476 (14%)

Query: 119  LMTEVMKLQKKVQDLTALLSSKDD----FIKELRVKDSLLRKHQERVQRLKEECEAGSRE 174
            L  +V KLQ ++ ++T LLS  D       K+    +S L+  QE +Q    +  + S +
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKL 234
            LK+ ++E      +L  + E K     +   L  ++  +K  +  +    +   +   KL
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390

Query: 235  RHAME---QRPSQELLW--ELQQEKALLQARVQELEASVQEGKLD------RSSPYIQVL 283
            +  +E   QR  +++    +L++ K  LQ  + +L   +   +        +   + Q+L
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450

Query: 284  EEDWR----------QALRDHQEQANTIFSLRKDL-----RQGEARRLRCMEEKEMFELQ 328
             E+            +A  + +E+     SL + L     ++ E  RL      EM +L 
Sbjct: 1451 AEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510

Query: 329  CL---------ALRKDSKMYKDRIEAILLQMEEV--AIERDQAIATREELHAQHARGLQE 377
                        L K  +  + ++E +  Q+EE+   ++  +    R E++ Q  +   E
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570

Query: 378  KDALRKQVRELGEKADELQLQVFQCEAQL--------LAVEGRLRRQQLETLVLSSDLED 429
            +D L+ +  +  EK  +L  QV + EA+L        +AV  R ++ +++   L + ++ 
Sbjct: 1571 RD-LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR-KKLEMDLKDLEAHIDS 1628

Query: 430  GSPRRSQEL-----------SLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQV-LRNP 477
             +  R + +              ++L+DT+ S +  LA     ++   ++  E + L+  
Sbjct: 1629 ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEE 1688

Query: 478  HDAGLSSGEPPEKERRRLKESFENYRRKRAL-----RKMQKGWRQGEEDRENTTGS 528
              A   +    ++ER  L +   N   K AL     R+++    Q EE+ E   G+
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 83/418 (19%), Positives = 176/418 (42%), Gaps = 56/418 (13%)

Query: 121  TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELK---- 176
            T + + ++K + L  L +  +  I +L  +     K ++ +++ + + E  S +L     
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065

Query: 177  RCKEENYDLAMRLAHQSEE--------------KGAALMRNRDLQLEIDQLKHSLMKAED 222
              + +  +L M+LA + EE              K  AL + R+L+ +I +L+  L     
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125

Query: 223  DCKVERKHTLKLRHAME------------QRPSQELLWELQQEKALLQARVQELEASVQE 270
                  K    L   +E                QEL  + +QE  +L+  ++E EA   E
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHE 1184

Query: 271  GKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMF-ELQC 329
             +       IQ + +   QA+ +  EQ      ++ +L   +A++    E  E+  E++ 
Sbjct: 1185 AQ-------IQEMRQKHSQAVEELAEQLEQTKRVKANLE--KAKQTLENERGELANEVKV 1235

Query: 330  LALRK-DSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVREL 388
            L   K DS+  + ++EA   Q++E+ ++ ++    R EL  +  +   E D +   + + 
Sbjct: 1236 LLQGKGDSEHKRKKVEA---QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292

Query: 389  GEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQ 448
              K+ +L       E+QL   +  L+ +  + L LS+ L+     ++   S  + LE+ +
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN---SFREQLEEEE 1349

Query: 449  LSDKGCLAGGGSPKQPFAALH-QEQVLRNPHDAGLSSGEPPEKERRRLKESFENYRRK 505
             +           ++  A LH Q   ++   +  +   E  E+ +R+L++  E   ++
Sbjct: 1350 EAKHNL-------EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR 1400


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 89/448 (19%), Positives = 186/448 (41%), Gaps = 75/448 (16%)

Query: 116 TQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSREL 175
           +QL   ++ +LQK++++   LL ++ D    LR   + + K   +++ L  E +  +R L
Sbjct: 533 SQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRIL 592

Query: 176 KRCKEEN----YDLAMRL-------AHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDC 224
           +  K +     Y L   L        H SE  G    R   LQ E+  LKH+L K E + 
Sbjct: 593 ENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGER 652

Query: 225 K---------VERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDR 275
           K          + K+ L++    + +  Q+ L +   E  + +AR+ +   S++E K   
Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAK--- 709

Query: 276 SSPYIQVLEEDWRQALRDHQEQANTIFSLRK-------DLRQGEARRLRCMEEKEMFELQ 328
            S  +  +E+  ++     ++  N +  + K       DL+Q + +       KE  E  
Sbjct: 710 -SVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERME-- 766

Query: 329 CLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREEL-----HAQHARGLQEKDALRK 383
                       D ++ + LQ+E+   E ++ +  + EL      A + +GL+++  +++
Sbjct: 767 ------------DEVKNLTLQLEQ---ESNKRLLLQNELKTQAFEADNLKGLEKQ--MKQ 809

Query: 384 QVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQD 443
           ++  L E    L+ ++ Q   Q    EG++R  Q +   L ++    +  ++Q   L ++
Sbjct: 810 EINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQ---LEAEQYFSTLYKTQVKELKEE 866

Query: 444 LEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
           +E+    +          K+     ++++ L    D   +  E  +  R  L+E +    
Sbjct: 867 IEEKNRENL---------KKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQY---- 913

Query: 504 RKRALRKMQKGWRQGEEDRENTTGSDNT 531
                   Q+  +    +R+  T  D+T
Sbjct: 914 ----FELTQESKKAASRNRQEITDKDHT 937



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 64/321 (19%), Positives = 135/321 (42%), Gaps = 55/321 (17%)

Query: 83   LELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQD--------LT 134
            LE    QL K+  G E  ++  +      E   + L  T+V +L++++++        + 
Sbjct: 821  LEFELAQLTKQYRGNE-GQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQ 879

Query: 135  ALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQ-S 193
             L + K+    +L + ++     Q     L+E+    ++E K+    N        H  S
Sbjct: 880  ELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVS 939

Query: 194  EEKGAALMRNRDLQL---EIDQLKHSLMKAEDDCKVERKHTL-KLRHAMEQRPSQELLWE 249
              + A  M  +D+++   E ++L   + KAE++ K+E++  +  L+ A E+  + E   +
Sbjct: 940  RLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLK 999

Query: 250  LQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLR 309
             Q    L +        + ++ K+DR                    ++ANT     +DLR
Sbjct: 1000 TQAVNKLAEI------MNRKDFKIDR--------------------KKANT-----QDLR 1028

Query: 310  QGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHA 369
            +         +EKE  +LQ L L ++ + +   +     ++ ++  +  +  A R EL  
Sbjct: 1029 K---------KEKENRKLQ-LELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQM 1078

Query: 370  QHARGLQEKDALRKQVRELGE 390
            Q A    + + LR ++ +L +
Sbjct: 1079 QLASKESDIEQLRAKLLDLSD 1099



 Score = 32.7 bits (73), Expect = 0.86
 Identities = 39/233 (16%), Positives = 101/233 (43%), Gaps = 51/233 (21%)

Query: 209 EIDQLKHSLMKAEDDCKVE-RKHTLKLRHAMEQ--------RPSQELLWELQQEKALLQA 259
           ++++  H+ M+ +D+ + + R   +KL   M++        R  +  + ++++EK LLQ 
Sbjct: 434 KLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQH 493

Query: 260 RVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCM 319
           R+ E +   ++    R                R+ + + +T+    +DL++         
Sbjct: 494 RINEYQRKAEQENEKR----------------RNVENEVSTLKDQLEDLKK--------- 528

Query: 320 EEKEMFELQCLALRKDSKMYKDRIEAILLQMEE----VAIERDQAIATREELHAQHARGL 375
                       + ++S++  +++  +  Q+EE    +  E D A+  R+  H + ++ +
Sbjct: 529 ------------VSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKS-HTEMSKSI 575

Query: 376 QEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLE 428
            + ++L ++++E     +  + Q  +   QL A+    RR +     +  DL+
Sbjct: 576 SQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQ 628


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 85/363 (23%), Positives = 160/363 (44%), Gaps = 53/363 (14%)

Query: 119  LMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRC 178
            L + +  + K   +L  +  + +D + E R K+  +++    +   K   +  + EL R 
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291

Query: 179  KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQ-------LKHSLMKAEDDCKV----- 226
             EE   +  +L   S  K A   +  +L+ ++++       L H+L  +  DC +     
Sbjct: 1292 LEEKESIVSQL---SRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQY 1348

Query: 227  --ERKHTLKLRHAMEQRPSQELLW-------------ELQQEKALLQARVQELEASVQE- 270
              E++   +L+ A+ +  S+   W             EL++ K  L  R+Q+ E  V+  
Sbjct: 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408

Query: 271  ----GKLDRSSPYIQVLEEDWRQALRDHQEQANTIFS-LRKDLRQGEAR----RLRCMEE 321
                  L+++   +Q   ED    L    E+AN++ + L K  R  +      + +C E 
Sbjct: 1409 NAKCASLEKTKQRLQGEVED----LMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEES 1464

Query: 322  KEMFEL---QCLALRKDSKMYKDRIEAILLQMEEVAIER---DQAIATREELHAQHARGL 375
            +   E    +  +L  +    K+  E  L Q+E V  E    +Q IA   E  A++ + +
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524

Query: 376  QEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRS 435
             E +  RKQ+ EL EKAD +QL + + EA L   E ++ R QLE   + S+++     + 
Sbjct: 1525 HELEKSRKQI-EL-EKAD-IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKD 1581

Query: 436  QEL 438
            +E+
Sbjct: 1582 EEI 1584



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 70/344 (20%), Positives = 147/344 (42%), Gaps = 67/344 (19%)

Query: 119  LMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRC 178
            L+    +L+ K++++T     +++   EL  K    RK ++    LK++ +         
Sbjct: 909  LIKAKFQLEAKIKEVTERAEDEEEINAELTAKK---RKLEDECSELKKDID--------- 956

Query: 179  KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCK-VERKHTLKLRHA 237
                 DL + LA   +EK A   + ++L  E+  L  ++ K   + K ++  H   L   
Sbjct: 957  -----DLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD-- 1009

Query: 238  MEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQ 297
             + +  ++ +  L + K+ L+ +V++LE+S+++ K  R       LE + R+   D +  
Sbjct: 1010 -DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD-----LERNKRKLEGDLKLA 1063

Query: 298  ANTIFSLRKDLRQGEARRLR-----CMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEE 352
              +I  L  D +Q + R  +     C  + ++ + Q L L+     ++ +I+ +  ++EE
Sbjct: 1064 QESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQ-----FQKKIKELQARIEE 1118

Query: 353  VAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGR 412
            +  E +   ATR +   Q +   +E + L +++ E G                       
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG---------------------- 1156

Query: 413  LRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLA 456
                     V S+ +E    R ++ L L +DLE+  L  +  +A
Sbjct: 1157 ---------VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 83/347 (23%), Positives = 146/347 (42%), Gaps = 52/347 (14%)

Query: 122  EVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEE 181
            E  +LQ KV+D   L       IKEL          Q R++ L+EE EA      + +++
Sbjct: 1087 EYCQLQSKVEDEQTLGLQFQKKIKEL----------QARIEELEEEIEAERATRAKTEKQ 1136

Query: 182  NYDLAMRLAHQSEEKGAA---------LMRNRDLQ-------LEIDQLKHSLMKAEDDCK 225
              D A  L   SE    A         L + R+ +       LE   L+H  M A     
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA----A 1192

Query: 226  VERKHTLKLRHAMEQRPS-QELLWELQQEKALLQARVQELEASVQEGKLDRSS--PYIQV 282
            + +KH   +    EQ  + Q +  +L++EK+  +  + +L +S++     +++     + 
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRT 1252

Query: 283  LEEDWRQALRDHQEQANTIFSL--RKDLRQGEARRL-RCMEEKEMFELQCLALRKDSKMY 339
            LE+   +A   ++E   ++  L  +K   Q EA  L R +EEKE    Q   L +  + +
Sbjct: 1253 LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ---LSRSKQAF 1309

Query: 340  KDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQV 399
              + E +  Q+EE   E     A    L +       + D LR+Q  E  E   ELQ  +
Sbjct: 1310 TQQTEELKRQLEE---ENKAKNALAHALQSSR----HDCDLLREQYEEEQEGKAELQRAL 1362

Query: 400  FQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLED 446
             +  ++   V     + + + +  + +LE+   + +Q L   QD E+
Sbjct: 1363 SKANSE---VAQWRTKYETDAIQRTEELEEAKKKLAQRL---QDSEE 1403



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 64/322 (19%), Positives = 135/322 (41%), Gaps = 57/322 (17%)

Query: 124  MKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSREL-------K 176
            ++L +   ++   ++ KD+ I++L+      R +Q  V+ ++   +A  R         K
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLK------RNYQRTVETMQSALDAEVRSRNEAIRLKK 1617

Query: 177  RCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRH 236
            + + +  ++ ++L+H + +    L   R +Q    QLK + +  +D  +           
Sbjct: 1618 KMEGDLNEIEIQLSHANRQAAETLKHLRSVQ---GQLKDTQLHLDDALR----------- 1663

Query: 237  AMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQE 296
               Q   +E L  +++   LLQA V+EL A++++ +  R     ++L+ + R  L  H +
Sbjct: 1664 --GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL-HTQ 1720

Query: 297  QANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIE 356
              + I + +K            M+ +   E      R   +  K  I    +  EE+  E
Sbjct: 1721 NTSLIHTKKK-------LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773

Query: 357  RDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQ 416
            +D +           A   + K  L + V++L  + DE +        QL    G+ + Q
Sbjct: 1774 QDTS-----------AHLERMKKNLEQTVKDLQHRLDEAE--------QLALKGGKKQIQ 1814

Query: 417  QLETLVLSSDLE-DGSPRRSQE 437
            +LET +   + E +G  +++ E
Sbjct: 1815 KLETRIRELEFELEGEQKKNTE 1836



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 33/150 (22%), Positives = 68/150 (45%), Gaps = 13/150 (8%)

Query: 305  RKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAIL---LQMEEVAIERDQAI 361
            RK+L   E + +  ++EK   +LQ  A  ++    ++R + ++    Q+E    E  +  
Sbjct: 871  RKEL---EEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERA 927

Query: 362  ATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETL 421
               EE++A+      +K  L  +  EL +  D+L+L + + E +  A E +++    E  
Sbjct: 928  EDEEEINAELTA---KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEL- 983

Query: 422  VLSSDLEDGSPRRSQELSLPQDLEDTQLSD 451
               S L++   + ++E    Q+     L D
Sbjct: 984  ---SGLDETIAKLTREKKALQEAHQQALDD 1010


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 81/337 (24%), Positives = 152/337 (45%), Gaps = 63/337 (18%)

Query: 127  QKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERV-------QRLKEECEAGSRELKRCK 179
            QK  +    L + K+  + ++  KD  L+  QE V       Q+++EE    ++  +  +
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916

Query: 180  EENYDLAMRLAHQSEEKGAAL-----------MRNRDLQLEIDQLKHSLMKAEDD----- 223
            EE  DL  RL +Q  E   ++           ++N  L+ E+  LK  + + E++     
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976

Query: 224  ---CKVE---RKHTLKLRHAMEQRPS--------QELLWELQQEKALLQA-------RVQ 262
                KVE   RK  L+     ++ P         QELL E QQE   LQ        ++ 
Sbjct: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKIS 2036

Query: 263  ELEASVQ--EGKLDRSSPYIQVLEEDWRQALRDHQEQANT---IFSLRKDLRQGEARRLR 317
             LE +V+  E     S   +++ +E+  QA+ +H+++A      F +  D  Q EA R+ 
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAV-EHRKKAQAELASFKVLLDDTQSEAARVL 2095

Query: 318  CMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQE 377
                        L L+K+ +  K+ +++ + Q +E   + ++ +   EE H +  + +QE
Sbjct: 2096 ADN---------LKLKKELQSNKESVKSQMKQKDE---DLERRLEQAEEKHLKEKKNMQE 2143

Query: 378  K-DALRKQVRELGEKADELQLQVFQCEAQLLAVEGRL 413
            K DALR++   L E   E+Q+ + + + ++  ++  L
Sbjct: 2144 KLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 78/340 (22%), Positives = 152/340 (44%), Gaps = 39/340 (11%)

Query: 121  TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE 180
            TEV +LQ+KV D   L     + + +L     L    Q  + +L+ E       LK  K+
Sbjct: 2270 TEV-QLQQKVCD--TLQGENKELLSQLEETRHLYHSSQNELAKLESE-------LKSLKD 2319

Query: 181  ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ 240
            +  DL+  L    E+KG      R  + +I   K S  + E D +  R+ T +L   +  
Sbjct: 2320 QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379

Query: 241  RPSQELLWELQQEKALLQARVQEL------EASVQEGKLDRSSPYIQVLEEDWRQALRDH 294
            +  Q+++  L  ++  +Q  + EL      E    E  L +      VLEE+ ++A+   
Sbjct: 2380 K-EQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKT 2438

Query: 295  QEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEE-- 352
             +   T+ +++K+  Q +A       + + F     +L+ D    +DRI     Q+EE  
Sbjct: 2439 NQLMETLKTIKKENIQQKA-------QLDSFVKSMSSLQND----RDRIVGDYQQLEERH 2487

Query: 353  --VAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEA---QLL 407
              + +E+DQ I   +E  A++ +  +E   LR  + +L  +  +L  ++ Q      Q++
Sbjct: 2488 LSIILEKDQLI---QEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544

Query: 408  AVEGRLRRQQLET-LVLSSDLEDGSPRRSQELSLPQDLED 446
             ++   ++Q LE  L  + +LE+   +  ++L   ++  +
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 77/331 (23%), Positives = 139/331 (41%), Gaps = 32/331 (9%)

Query: 119  LMTEVMKLQKKVQDLTA--------LLSSKDDFIKELRVKDS----LLRKHQERVQRLKE 166
            L  E+  L+  + DL +        L+  ++D  + + +KDS    LL    ++ + L+ 
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567

Query: 167  ECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMK-AEDDCK 225
            +      +LK  +E N DL        EEK       +DL  EI+ LK S+ +       
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEK-------QDLSKEIESLKVSISQLTRQVTA 2620

Query: 226  VERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEE 285
            ++ + TL L HA + +  +E +  L    +  Q R+ ELE  +   + + +   +  +E+
Sbjct: 2621 LQEEGTLGLYHA-QLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKK-VGEIED 2678

Query: 286  DWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEA 345
              ++ L+     A     +R +    E R      +    E + L + K++K    +I++
Sbjct: 2679 KLKKELKHLHHDAGI---MRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735

Query: 346  ILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQ---VRELGEKADELQLQVFQC 402
                M  +   RD A    +EL  ++   L+E   L++Q    RE      E    +   
Sbjct: 2736 FGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNST 2795

Query: 403  EAQLLAVEGRLRRQQL----ETLVLSSDLED 429
            E   L+   +L +Q L    + L LSS LED
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 83/360 (23%), Positives = 148/360 (41%), Gaps = 55/360 (15%)

Query: 119  LMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRC 178
            L  E  +LQKK+Q+  AL S K           ++L+K QE+ + L+E       ELK+ 
Sbjct: 1169 LEKEKEQLQKKLQE--ALTSRK-----------AILKKAQEKERHLRE-------ELKQQ 1208

Query: 179  KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAED---DCKVERKHTLKLR 235
            K++   L  +   QS+E      + R LQ+++ +     + + D    C         L 
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268

Query: 236  HAMEQRPSQELL-------WELQQEK----------ALLQARVQELEASVQEGKLDRSSP 278
             A EQ  +Q +L       W    E           A ++A+++E+EA   E +L  SS 
Sbjct: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST 1328

Query: 279  YIQVLE--EDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDS 336
              ++ +  E+  Q      +Q   I SL+    + E       ++ E  +LQ   L    
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH-- 1386

Query: 337  KMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKD-ALRKQVRELGEKADEL 395
                      L +++    E  + I+ +EE  +  +  L EK+ AL K   E+ E+ D +
Sbjct: 1387 ----------LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436

Query: 396  QLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCL 455
            +    Q E Q    + R+++ Q+E   +    E+       +  + + L+   +S K  L
Sbjct: 1437 KALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEAL 1496



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 86/477 (18%), Positives = 191/477 (40%), Gaps = 60/477 (12%)

Query: 77   VAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQKKVQDLTAL 136
            ++ +  L     QL   +   E  R        + ++ LT+ + +  ++ + K   +  L
Sbjct: 756  LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815

Query: 137  LSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAHQSEEK 196
             +  DD   +   + +L+R  Q ++Q  + E   G+  ++    +  +L+  L+ +    
Sbjct: 816  QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK---- 871

Query: 197  GAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQ---------ELL 247
                      +LEI ++   L++ + D +        L+  +E++  Q         E +
Sbjct: 872  ----------ELEITKMDQLLLEKKRDVET-------LQQTIEEKDQQVTEISFSMTEKM 914

Query: 248  WELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEE-DWRQALRDHQEQANTIFSLRK 306
             +L +EK  L   ++ L+  +        +   QV E+ +    L+ + ++ +    + K
Sbjct: 915  VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974

Query: 307  DLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREE 366
            +  Q E   L+   E+   +LQ   + +     K+ ++ +    EE+A  +D+  + +E 
Sbjct: 975  EELQHEFDLLKKENEQRKRKLQAALINR-----KELLQRVSRLEEELANLKDE--SKKEI 1027

Query: 367  LHAQHARGLQEKDALRKQVRE--LGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLS 424
              ++  RG  E+D   K+  E  +  K  E+++ + Q  ++       +R+   E L   
Sbjct: 1028 PLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087

Query: 425  SDLEDGSPRRSQELS--------LPQDLEDTQ-LSDKGCLAGGGSPKQPFAALHQEQVLR 475
               +    + +Q L         L  ++ + Q +  K   +   +      AL +E V+ 
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147

Query: 476  NPHDAGLSSGEPP---------EKERRRLKESFEN--YRRKRALRKMQKGWRQGEED 521
            +P   G S    P         EKE+ +L++  +     RK  L+K Q+  R   E+
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE 1204



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 99/429 (23%), Positives = 175/429 (40%), Gaps = 68/429 (15%)

Query: 136  LLSSKDDFIKELRVKDSLLRKHQERVQRLKE---ECEAGSRELKRCKEENYDLA------ 186
            L S+K D  K L     + + HQ+ ++RLK    E E    + +   E+N D        
Sbjct: 661  LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720

Query: 187  --------MRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAM 238
                     + A  +     AL   RD QL + Q+K   M  E   +V++   + L  A 
Sbjct: 721  LNQLIEEFKKNADNNSSAFTALSEERD-QL-LSQVKELSMVTELRAQVKQLE-MNLAEAE 777

Query: 239  EQRPSQELLWELQ-QEKALLQARVQEL--EASVQEGKLDRSSPYIQVLEEDWRQALRDHQ 295
             QR    L +E Q     LL  ++  L  EA  ++ K       I+VL+ +         
Sbjct: 778  RQR---RLDYESQTAHDNLLTEQIHSLSIEAKSKDVK-------IEVLQNELDDVQLQFS 827

Query: 296  EQANTIFSLRKDLRQGE------ARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQ 349
            EQ+  I SL+  L+  E      A R+R +  K     Q L+ +          E  + +
Sbjct: 828  EQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK----------ELEITK 877

Query: 350  MEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAV 409
            M+++ +E+ + + T ++        ++EKD   +QV E+     E  +Q+ + E   L V
Sbjct: 878  MDQLLLEKKRDVETLQQT-------IEEKD---QQVTEISFSMTEKMVQLNE-EKFSLGV 926

Query: 410  EGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALH 469
            E +  ++QL  L  + + +        E+S        ++S  G ++     +  F  L 
Sbjct: 927  EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS-KEELQHEFDLLK 985

Query: 470  QEQVLRNPH-DAGLSSGEPPEKERRRLKESFENY----RRKRALRKMQKGWRQGEEDREN 524
            +E   R     A L + +   +   RL+E   N     +++  L + ++G  + EED+EN
Sbjct: 986  KENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERG--EVEEDKEN 1043

Query: 525  TTGSDNTDT 533
               S+   T
Sbjct: 1044 KEYSEKCVT 1052



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 76/377 (20%), Positives = 158/377 (41%), Gaps = 36/377 (9%)

Query: 119  LMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRC 178
            L  E+ ++++K +++     +K    ++L+      ++  +  + L+EE       ++R 
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516

Query: 179  KEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAM 238
             +   D+  +++ Q++EK   L R   LQ E D+    L+   D   +E           
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDK----LITEMDRSLLE----------- 1561

Query: 239  EQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQA 298
                +Q L    +  K  L+   ++ E  V+E +  +SS   +  E  W++  ++ Q++ 
Sbjct: 1562 ----NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE--WQEKHKELQKEY 1615

Query: 299  NTIFSLRKDLRQGEARRLRCMEEKEMFELQCL-ALRKDSKMYKDRIEAILLQMEEVAIER 357
              +    +++   EA R++ + E    E Q L    + ++  K   E  L + E+   E 
Sbjct: 1616 EILLQSYENV-SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674

Query: 358  DQAIATREELHAQHARGLQEK-DALRKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQ 416
             + +    +   Q    L+E+ D LR +V   G+ A E    +    A   +++  L R 
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA---SMKEELERV 1731

Query: 417  QLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQPFAALHQEQVLRN 476
            ++E   LS   +      S++ SL ++++D     K  + G  S +    A  +     N
Sbjct: 1732 KMEYETLSKKFQS---LMSEKDSLSEEVQDL----KHQIEGNVSKQANLEATEKHDNQTN 1784

Query: 477  PHDAGLSS--GEPPEKE 491
              + G  S  GE  E++
Sbjct: 1785 VTEEGTQSIPGETEEQD 1801



 Score = 37.4 bits (85), Expect = 0.035
 Identities = 56/283 (19%), Positives = 135/283 (47%), Gaps = 30/283 (10%)

Query: 123 VMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEE- 181
           V++L+  ++     L  KD+ ++E R      +    ++++LK   +A    L +  EE 
Sbjct: 61  VVELKDIIRQKDVQLQQKDEALQEER------KAADNKIKKLKLHAKAKLTSLNKYIEEM 114

Query: 182 --NYDLAMRLAHQSEEKGAALMRNR-DLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAM 238
                  +    QSEE+ +   ++  + ++EI+++KH L + E+     +    +L  A 
Sbjct: 115 KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ---AQLTQAQ 171

Query: 239 EQRPSQEL--LWELQQEKALLQAR---VQELEASVQEGKLDRSSPYIQVLEEDWR--QAL 291
            ++P+Q    + E    K  LQ +   +  L+A + + + ++++  + V E+D R    +
Sbjct: 172 AEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQV-VREKDARFETQV 230

Query: 292 RDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQME 351
           R H+++   + + + D+     ++LR ++ K       L   ++S + + ++  +L Q  
Sbjct: 231 RLHEDELLQLVT-QADVETEMQQKLRVLQRK-------LEEHEESLVGRAQVVDLLQQEL 282

Query: 352 EVAIERDQAIATR-EELHAQHARGLQEKDALRKQVRELGEKAD 393
             A +R+Q ++ + +++ A+H       +  R++ + L EK +
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKME 325



 Score = 36.6 bits (83), Expect = 0.059
 Identities = 74/353 (20%), Positives = 151/353 (42%), Gaps = 46/353 (13%)

Query: 121 TEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKE 180
           T+V   + ++  L      + +  ++LRV    L +H+E +    +  +   +EL   ++
Sbjct: 228 TQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQ 287

Query: 181 ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERK---HTL--KLR 235
            N  L+ +L     E     +RN  ++ E ++ K  L K E +   ERK   H L  ++ 
Sbjct: 288 RNQILSQQLQQMEAEHNT--LRN-TVETEREESKILLEKMELEV-AERKLSFHNLQEEMH 343

Query: 236 HAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLE---EDWRQALR 292
           H +EQ        +  Q +A L++R   LE    + +++  + +I  L+   ++ + A  
Sbjct: 344 HLLEQ------FEQAGQAQAELESRYSALEQK-HKAEMEEKTSHILSLQKTGQELQSACD 396

Query: 293 DHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEE 352
             ++Q + +   + +     A+ ++ +E++         L++ SK     +  + LQ  E
Sbjct: 397 ALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ---------LQQKSKEISQFLNRLPLQQHE 447

Query: 353 VAI---------ERDQAIATREELHAQHARGLQ---EKDALRKQVRELGEKADELQLQVF 400
            A          E  QA+ T E + +   R ++   EK AL     EL    +EL+ +  
Sbjct: 448 TASQTSFPDVYNEGTQAV-TEENIASLQKRVVELENEKGALLLSSIEL----EELKAENE 502

Query: 401 QCEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQEL-SLPQDLEDTQLSDK 452
           +  +Q+  +E + R  + +  V    + D + +RS       QD+ +   S K
Sbjct: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQK 555


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 110/469 (23%), Positives = 206/469 (43%), Gaps = 64/469 (13%)

Query: 10   CWSVLEGFRVTLTSVIDPSRIT--PYLRQCKVLNPD-------DEEQVLS--------DP 52
            C  VLEG R+       P+RI    + ++ ++L P+       D +Q           DP
Sbjct: 701  CNGVLEGIRICRQGF--PNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDP 758

Query: 53   NLV-IRKRKV----GVLLDILQRTGHK--GYVAFLESLELYYPQLYKKVTGKEPARVFSM 105
            NL  I + K+    GVL  + +    K    + F +++   Y  L +K   K+  ++ ++
Sbjct: 759  NLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGY--LARKAFAKKQQQLSAL 816

Query: 106  IIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLK 165
             +     +   +L   +  ++  KV+ L  +   ++    EL+ KD  L K +E+  +++
Sbjct: 817  KVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEE----ELQAKDEELLKVKEKQTKVE 872

Query: 166  EECEAGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCK 225
             E E   R+ ++  EE   LA +L  ++E           L  E ++++  L   + + +
Sbjct: 873  GELEEMERKHQQLLEEKNILAEQLQAETE-----------LFAEAEEMRARLAAKKQELE 921

Query: 226  VERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEE 285
             E  H L+ R   E+  +Q L    Q EK  +QA +Q+LE  + E +  R    ++ +  
Sbjct: 922  -EILHDLESRVEEEEERNQIL----QNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTA 976

Query: 286  DWRQALRDHQ----EQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKD 341
            + +    + +    E  N+ F   K L   E R   C  +    E +   L K     ++
Sbjct: 977  EAKIKKMEEEILLLEDQNSKFIKEKKLM--EDRIAECSSQLAEEEEKAKNLAK----IRN 1030

Query: 342  RIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQ 401
            + E ++  +EE   + ++   TR+EL     +   E   L+ Q+ EL  + DEL+LQ+ +
Sbjct: 1031 KQEVMISDLEERLKKEEK---TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087

Query: 402  CEAQLLAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLS 450
             E +L   +G L R   ETL  ++ L+     ++Q   L +D E  + S
Sbjct: 1088 KEEEL---QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 75/345 (21%), Positives = 158/345 (45%), Gaps = 38/345 (11%)

Query: 119  LMTEVMKLQKKVQD----LTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRE 174
            ++ ++ KLQ +++D    L    +S+D+   + +  +  L+  +  + +L+EE  +  R 
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702

Query: 175  LKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKV----ERKH 230
             +  ++E  +LA  + + +  K A L   R L+  I QL+  L + + + ++     RK 
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762

Query: 231  TLKL-----RHAMEQRPSQE---LLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQV 282
            TL++       A E+  +Q+      +L+++   L+A++QELE +V+     +    I  
Sbjct: 1763 TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK----SKFKATISA 1818

Query: 283  LEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKD- 341
            LE    Q     +++A    +  K +R+ E +       KE+F +Q    R+ +  YK+ 
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKL------KEIF-MQVEDERRHADQYKEQ 1871

Query: 342  ------RIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELG---EKA 392
                  R++ +  Q+EE   E  +A A+R +L  +     +  + L ++V  L     + 
Sbjct: 1872 MEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1931

Query: 393  DELQLQVFQCEAQLLAVEG-RLRRQQLETLVLSSDLEDGSPRRSQ 436
              +     +   + L +EG  L     +T   +SD+ +  P +S+
Sbjct: 1932 GPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQSE 1976



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 69/333 (20%), Positives = 138/333 (41%), Gaps = 33/333 (9%)

Query: 125  KLQKKVQDLTALLSSKDDFIKELRVK----DSLLRKHQERVQRLKEECEAGSRELKRCKE 180
            +LQ+++ DLT  L  +      L  K    D LL + +    R  EE +    E +  + 
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483

Query: 181  ENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQ 240
            +   LA  L    E K     +N+ L+ +++ L    M ++DD         K + A+EQ
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDL----MSSKDDVGKNVHELEKSKRALEQ 1539

Query: 241  RPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQ--- 297
                    ++++ +  L+    EL+A+ ++ KL R    +Q ++  + + L+   EQ   
Sbjct: 1540 --------QVEEMRTQLEELEDELQAT-EDAKL-RLEVNMQAMKAQFERDLQTRDEQNEE 1589

Query: 298  -----ANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEE 352
                    +  L  +L     +R   +  K+  E+       D K  + +IEA     +E
Sbjct: 1590 KKRLLIKQVRELEAELEDERKQRALAVASKKKMEI-------DLKDLEAQIEAANKARDE 1642

Query: 353  VAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQLLAVEGR 412
            V  +  +  A  ++   +       +D +  Q +E  +K   L+ ++ Q + +L + E  
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702

Query: 413  LRRQQLETLVLSSDLEDGSPRRSQELSLPQDLE 445
             R  + E   L+ ++ + +  +S  L   + LE
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLE 1735



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 61/294 (20%), Positives = 140/294 (47%), Gaps = 23/294 (7%)

Query: 112  ESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVK----DSLLRKHQERVQRLKEE 167
            E    Q+L  E  K+Q  +QDL   L  ++   ++L+++    ++ ++K +E +  L+++
Sbjct: 934  EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993

Query: 168  CEAGSRELKRCKEENYDLAMRLAHQSEE-KGAALMRNRDLQLEIDQLKHSLMKAEDDCKV 226
                 +E K  ++   + + +LA + E+ K  A +RN+  ++ I  L+  L K E     
Sbjct: 994  NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ-EVMISDLEERLKKEEK---- 1048

Query: 227  ERKHTLKLRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEED 286
             R+   K +  ++   +     +LQ + A LQA++ EL+  + + + +      +  +E 
Sbjct: 1049 TRQELEKAKRKLDGETT-----DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103

Query: 287  WRQ--ALRDHQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIE 344
              +  AL+  +E    I  L++D    +A R +  ++K     +  AL+ +    +D ++
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE---LEDTLD 1160

Query: 345  AILLQMEEVAIERDQAIATREELHAQHARG--LQEKDALRKQVRELGEKADELQ 396
                Q +E+  +R+Q +A  ++   +  +    Q +D  ++    L E +++L+
Sbjct: 1161 TTAAQ-QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 91/416 (21%), Positives = 174/416 (41%), Gaps = 59/416 (14%)

Query: 131  QDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLA 190
            ++L AL +  +D +     +  L  K ++ V  LK+  E    E K  + +  D+  R A
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE---EETKNHEAQIQDMRQRHA 1202

Query: 191  HQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWEL 250
               EE    L + +  +  +++ K  L   E D K           A E +  Q++  E 
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGL---ETDNK---------ELACEVKVLQQVKAES 1250

Query: 251  QQEKALLQARVQELEASVQEG-----KLDRSSPYIQ--------VLEEDWRQALRDHQEQ 297
            + ++  L A+VQEL A V EG     +L   +  +Q        +LEE  ++ ++  ++ 
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310

Query: 298  ANTIFSLR--KDLRQGEAR-------RLRCM-EEKEMFELQCLALRKDSKMYKDRIEAIL 347
            A+    L+  ++L Q E R       R+R + EEK   + Q     +  K  + ++ A+ 
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370

Query: 348  LQMEEVAIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQL- 406
             Q+ +   + D  + T E L     + L++ +AL +++ E     D+L+    + + +L 
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430

Query: 407  ---------LAVEGRLRRQQLETLVLSSDLEDGSPRRSQELSLPQ----DLEDTQLSDKG 453
                       V   L ++Q +   L ++ +  S R ++E    +    + E   LS   
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490

Query: 454  CLAGGGSPKQPFAALHQ------EQVLRNPHDAGLSSGEPPEKERRRLKESFENYR 503
             L      K+ F   ++      E ++ +  D G +  E  EK +R L++  E  R
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-LEKSKRALEQQVEEMR 1545


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 92/414 (22%), Positives = 188/414 (45%), Gaps = 46/414 (11%)

Query: 125  KLQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECEAGSRELKRCKEENYD 184
            +L++KV +LT  L   ++ +KE    D  L K   +++ L E+ E  S E+K   EEN  
Sbjct: 640  ELEQKVNELTGGL---EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNK 696

Query: 185  LAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQ 244
            L+      SE+K      +RDL++ + Q +  ++K E   ++E+K  L +    EQ    
Sbjct: 697  LS------SEKK----QLSRDLEVFLSQKEDVILK-EHITQLEKKLQLMVE---EQDNLN 742

Query: 245  ELLWELQQEKALLQAR----VQELEASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANT 300
            +LL   Q +K  ++ +    ++E+ + V E   ++    + VL+       + ++E+ N 
Sbjct: 743  KLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD--VVNVLQAVGESLAKINEEKCNL 800

Query: 301  IFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQA 360
             F   + + + E + ++C++E+ +  +QC  L+   + Y+     +  ++EE+  E++  
Sbjct: 801  AFQRDEKVLELE-KEIKCLQEESV--VQCEELKSLLRDYEQEKVLLRKELEEIQSEKEAL 857

Query: 361  IATREELHAQHARGLQEKDALRKQVRELGE--KADELQLQVFQC------EAQLLAVEGR 412
             +   E+   + +   E   L  QV E+ +     E+  +  +C        + L  +  
Sbjct: 858  QSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE 917

Query: 413  LRRQQLETLVLSSDLEDGSPRRSQELSLPQDLED-TQLSDKGCLAGGGSPKQPFAALHQE 471
            LR ++ E ++L   L      ++  LS  ++LE+  +  +K C       K+    +++ 
Sbjct: 918  LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC-------KEKEEKINKI 970

Query: 472  QVLRNPHDAGLSSGEPPEKERRRLKESFENYR-RKRALRKMQKGWRQGEEDREN 524
            +++       L S     KE + +KE  E+ R  K  L    +   QG E  +N
Sbjct: 971  KLVAVKAKKELDSS---RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 80/410 (19%), Positives = 170/410 (41%), Gaps = 31/410 (7%)

Query: 44   DEEQVLSDPNLVIRKRKVGVLLDILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVF 103
            +E+  L + NL+I+  +V       +    K    F++  E   P L +K      A + 
Sbjct: 868  NEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK-CFIKEHENLKPLLEQKELRDRRAELI 926

Query: 104  SMIIDASGESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRVKDSLLRKH----QE 159
             +    +    +    ++ V +L++K+++L      K++ I ++++     +K     ++
Sbjct: 927  LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRK 986

Query: 160  RVQRLKEECE----------AGSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLE 209
              Q +KEE E          A  R+L +  E   +L +    QSE+      R  + +  
Sbjct: 987  ETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHR 1046

Query: 210  IDQLKHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELL-----WELQQEKALLQARVQEL 264
            I+ L   L  +   C+        L   +E   S   L      E+Q+ KA++   + E 
Sbjct: 1047 IEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKEL-EA 1105

Query: 265  EASVQEGKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDLRQGEARRLRCME---- 320
            E   +E K+   +  +  LEE   Q  ++ ++   T+  L    +  +   L  ME    
Sbjct: 1106 EKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADY 1165

Query: 321  EKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDA 380
            E+ M EL      K++K+ +D  + I +Q ++    +++  + +  +     +  + K  
Sbjct: 1166 ERLMKELNQKLTNKNNKI-EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQL 1224

Query: 381  LRKQVRELGE----KADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSD 426
            L K  +EL +    + D L LQ    + +L A + ++   +++   ++S+
Sbjct: 1225 LVKTKKELADSKQAETDHLILQA-SLKGELEASQQQVEVYKIQLAEITSE 1273



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 65/260 (25%), Positives = 109/260 (41%), Gaps = 41/260 (15%)

Query: 92   KKVTGKEPARVFSMIIDAS--GESGLTQLLMTEVMKLQKKVQDLTALLSSKDDFIKELRV 149
            K++   + A    +I+ AS  GE   +Q    EV K+Q     L  + S K    + L+ 
Sbjct: 1230 KELADSKQAETDHLILQASLKGELEASQQ-QVEVYKIQ-----LAEITSEKHKIHEHLKT 1283

Query: 150  K----DSLLRKHQERVQRLKEECEAGSRELKRCKEENYDLAMRLAH-----------QSE 194
                    L  +Q+RV  L+EEC A   E      E     +R+ +           Q+E
Sbjct: 1284 SAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE 1343

Query: 195  EKGAALMRNRDLQLEIDQLKHSLMKAEDDCK--VERKHTLKLRHAMEQRPSQELLWELQQ 252
             +GA   R   L++ IDQLK  L  ++++ +  V    TL+  H        ++L    Q
Sbjct: 1344 TEGAKQEREH-LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKML----Q 1398

Query: 253  EKALLQARVQELEASVQEGKLDRSSPYIQ----------VLEEDWRQALRDHQEQ-ANTI 301
            E    +A ++E   S+Q   +   S + Q          VL   +R  +R  QE+   T+
Sbjct: 1399 ETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTV 1458

Query: 302  FSLRKDLRQGEARRLRCMEE 321
             +L++ L + EA+  +   E
Sbjct: 1459 ETLQQQLSKMEAQLFQLKNE 1478



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 79/350 (22%), Positives = 147/350 (42%), Gaps = 57/350 (16%)

Query: 119 LMTEVMKLQKKVQDLTALLSSKDDFIKELRVK-DSLLRKHQERVQRLKEECEAGSRELKR 177
           L   +  LQ+K       LS +D  +KEL  K +SL  +  + + +LK   E      K+
Sbjct: 557 LENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKK 616

Query: 178 CKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAEDDCKVERKHTLKLRHA 237
           C+ E   L + L  + E+    +  N +L+ ++++L   L   E+  K + ++  KL   
Sbjct: 617 CEREE-RLILELGKKVEQ---TIQYNSELEQKVNELTGGL---EETLKEKDQNDQKLEKL 669

Query: 238 MEQRPSQELLWELQQEKALLQARVQEL-----EASVQEGKLDR------SSPYIQVLEED 286
           M Q      +  L ++K +L A V+ L     + S ++ +L R      S     +L+E 
Sbjct: 670 MVQ------MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEH 723

Query: 287 WRQALRDHQEQANTIFSLRKDLRQGEARRL------------------RCMEEKEMFEL- 327
             Q  +  Q       +L K L   + ++L                     EEK++  + 
Sbjct: 724 ITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVL 783

Query: 328 ----QCLALRKDSK--MYKDRIEAILLQMEEVAIERDQAIATREELHAQHARGLQEKDAL 381
               + LA   + K  +   R E +L   +E+   +++++   EEL +      QEK  L
Sbjct: 784 QAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843

Query: 382 RKQVRELGEKADELQLQVFQCEAQLLAVEGRLRRQQLETLVLSSDLEDGS 431
           RK++ E+  + + LQ       + LL ++    + +LE   L   +E+ S
Sbjct: 844 RKELEEIQSEKEALQ-------SDLLEMKNANEKTRLENQNLLIQVEEVS 886



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 68/288 (23%), Positives = 129/288 (44%), Gaps = 61/288 (21%)

Query: 126 LQKKVQDLTALLSSKDDFIK-ELRVKDSLLR---KHQE----------RVQRLKEECEA- 170
           L +K +     LS K + IK +  V+DS+ +    H+E           ++ LK E  A 
Sbjct: 82  LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAV 141

Query: 171 ------GSRELKRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHS-------L 217
                     L++  EE  +  + L+ Q + +  +    + LQ EI++++         L
Sbjct: 142 RSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL 201

Query: 218 MKAEDDCKVERKHTL-KLRHAME------QRPSQELLWELQQEKALLQARVQELEASVQE 270
            K  D    E+K T+ +L++ +E      Q+    L  EL Q KA+ Q  V+EL   ++ 
Sbjct: 202 QKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIE- 260

Query: 271 GKLDRSSPYIQVLEEDWRQALRDHQEQANTIFSLRKDL-RQGEARRLRCMEEKEMFELQC 329
                              + ++H+ + N +  L+++L +Q EA   + +++K   EL+ 
Sbjct: 261 ------------------ASAKEHEAEINKLNELKENLVKQCEASE-KNIQKKYECELEN 301

Query: 330 LALRKDSKMYKDRIEAILLQ----MEEVAIERDQAIA-TREELHAQHA 372
           L     +    ++I +ILLQ    +E+V  E+ + +  T +EL +QH+
Sbjct: 302 LRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 349



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 52/237 (21%), Positives = 95/237 (40%), Gaps = 29/237 (12%)

Query: 321 EKEMFELQCLALRKDSKMYKDRIEAILLQMEEVAIERDQAIAT--------REELHAQHA 372
           EK   E QCL+L+K++   K  +E  + +M +   E +Q+           + EL A  +
Sbjct: 84  EKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRS 143

Query: 373 RGLQEKDALRKQVRELGEKADELQLQV-FQCEAQLLAVEGRLRRQQLETLVLSSDLEDGS 431
           +  ++K  L+KQ+ E      EL  Q+ FQ  +     E  +++ Q E   +    E+  
Sbjct: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNS-----EDNVKKLQEEIEKIRPGFEEQI 198

Query: 432 PRRSQELSLPQDLEDTQLSDKGCLAGGGSPKQ------------PFAALHQEQVLRNPHD 479
               ++L    D +   ++    +    S                  A+HQE+V      
Sbjct: 199 LYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQ 258

Query: 480 AGLSSGEPPEKERRRLKESFENYRR--KRALRKMQKGWRQGEEDRENTTGSDNTDTE 534
              S+ E  E E  +L E  EN  +  + + + +QK +    E+    T + N D +
Sbjct: 259 IEASAKE-HEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQ 314


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,338,676
Number of Sequences: 37866
Number of extensions: 966322
Number of successful extensions: 8838
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 772
Number of HSP's that attempted gapping in prelim test: 5236
Number of HSP's gapped (non-prelim): 2817
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.