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Search of human proteins with 4758808
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758808 RAS protein activator like 2 isoform 1 [Homo
sapiens]
(1139 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 2249 0.0
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 2220 0.0
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 1179 0.0
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 1166 0.0
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 967 0.0
gi|130502162 RAS protein activator like 3 [Homo sapiens] 431 e-120
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 178 3e-44
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 178 3e-44
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 132 1e-30
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 132 1e-30
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 132 1e-30
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 132 1e-30
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 132 2e-30
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 132 2e-30
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 132 2e-30
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 113 1e-24
gi|4759026 RAS protein activator like 1 [Homo sapiens] 110 6e-24
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 108 3e-23
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 103 7e-22
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 61 5e-09
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 59 3e-08
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 58 4e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 55 3e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 55 3e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 55 4e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 55 5e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 6e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 6e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 6e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 6e-07
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 2249 bits (5828), Expect = 0.0
Identities = 1139/1139 (100%), Positives = 1139/1139 (100%)
Query: 1 MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKL 60
MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKL
Sbjct: 1 MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKL 60
Query: 61 DRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSI 120
DRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSI
Sbjct: 61 DRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSI 120
Query: 121 LGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKD 180
LGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKD
Sbjct: 121 LGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKD 180
Query: 181 LAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKK 240
LAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKK
Sbjct: 181 LAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKK 240
Query: 241 KDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQ 300
KDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQ
Sbjct: 241 KDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQ 300
Query: 301 YKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRC 360
YKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRC
Sbjct: 301 YKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRC 360
Query: 361 GEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSEL 420
GEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSEL
Sbjct: 361 GEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSEL 420
Query: 421 IDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLR 480
IDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLR
Sbjct: 421 IDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLR 480
Query: 481 FLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHE 540
FLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHE
Sbjct: 481 FLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHE 540
Query: 541 WGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA 600
WGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA
Sbjct: 541 WGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA 600
Query: 601 KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHK 660
KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHK
Sbjct: 601 KLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHK 660
Query: 661 LKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQV 720
LKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQV
Sbjct: 661 LKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQV 720
Query: 721 EHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLS 780
EHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLS
Sbjct: 721 EHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLS 780
Query: 781 FQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQ 840
FQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQ
Sbjct: 781 FQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQ 840
Query: 841 SEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSM 900
SEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSM
Sbjct: 841 SEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSM 900
Query: 901 SVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA 960
SVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA
Sbjct: 901 SVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA 960
Query: 961 AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ 1020
AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ
Sbjct: 961 AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ 1020
Query: 1021 MQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQK 1080
MQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQK
Sbjct: 1021 MQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQK 1080
Query: 1081 IIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC 1139
IIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
Sbjct: 1081 IIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC 1139
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 2220 bits (5752), Expect = 0.0
Identities = 1128/1135 (99%), Positives = 1128/1135 (99%), Gaps = 7/1135 (0%)
Query: 5 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 64
EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT
Sbjct: 153 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 212
Query: 65 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD 124
SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD
Sbjct: 213 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD 272
Query: 125 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK 184
FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK
Sbjct: 273 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK 332
Query: 185 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN 244
KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
Sbjct: 333 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN 392
Query: 245 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF 304
NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF
Sbjct: 393 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF 452
Query: 305 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD 364
AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD
Sbjct: 453 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD 512
Query: 365 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ 424
VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ
Sbjct: 513 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ 572
Query: 425 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP 484
SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP
Sbjct: 573 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP 632
Query: 485 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM 544
AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM
Sbjct: 633 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM 692
Query: 545 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGP 604
KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK ATVAKLGP
Sbjct: 693 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGP 745
Query: 605 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP 664
LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP
Sbjct: 746 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP 805
Query: 665 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS 724
SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS
Sbjct: 806 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS 865
Query: 725 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP 784
VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP
Sbjct: 866 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP 925
Query: 785 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF 844
VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF
Sbjct: 926 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF 985
Query: 845 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS 904
SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS
Sbjct: 986 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS 1045
Query: 905 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL 964
AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL
Sbjct: 1046 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL 1105
Query: 965 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1024
NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL
Sbjct: 1106 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1165
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA
Sbjct: 1166 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1225
Query: 1085 QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC 1139
QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
Sbjct: 1226 QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC 1280
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 1179 bits (3050), Expect = 0.0
Identities = 656/1154 (56%), Positives = 827/1154 (71%), Gaps = 88/1154 (7%)
Query: 5 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 64
E P ER RRS+ G S SEK SM+ + +PF+V GF S+RLKGSIKRTKSQ KLDRN
Sbjct: 14 ESPQERPGSRRSLPG-SLSEKSPSMEPSAATPFRVTGFLSRRLKGSIKRTKSQPKLDRNH 72
Query: 65 SFR--LPSLRST------DDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPL 116
SFR LP RS ++RS +P+LKESRSHESLLSP S VE LDL E V +KP+
Sbjct: 73 SFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPV 132
Query: 117 HSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWII 176
HSSILGQD+CFEVT SGSKCFSC SA+ERDKWMENLRR V PNKDN RR E++L+LW+I
Sbjct: 133 HSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVI 192
Query: 177 EAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVE 236
EAKDL KKKY CELCLDD L+ARTT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +
Sbjct: 193 EAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETD 252
Query: 237 KKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITIL 296
KKKKK++N+Y+GLV++P ASV GRQFVEKWYPV TP P GK GP IRIK+R+QTITIL
Sbjct: 253 KKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITIL 312
Query: 297 PMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSE 356
PME YKEFAE +T++Y LC+ LEP++S + KEE+A ALVHILQSTG+ KDFLTDL+MSE
Sbjct: 313 PMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSE 372
Query: 357 VDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 416
VDRCG+++ LIFRENT+ATK+IEEYLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS
Sbjct: 373 VDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 432
Query: 417 SSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISAS 476
+++L +HQ NLKMCCELAFCKIINSYCVFPRELKEVFASW+Q+C +RG+ DISERLISAS
Sbjct: 433 AADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISAS 492
Query: 477 LFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDF 536
LFLRFLCPAIMSPSLFNL+QEYPDDRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN F
Sbjct: 493 LFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQF 552
Query: 537 LEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQ 596
LEHEW M+RFLLEISNP+T+SNT GF+GYIDLGRELS LHSLLWE VSQL+ Q
Sbjct: 553 LEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLE-------Q 605
Query: 597 ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSP-NVSGSLSSGLQKIFEDPTD 655
+ V+KLGPLPR+L D+ +L+ TP QL + S+P + S S+S+GLQK+ +
Sbjct: 606 SIVSKLGPLPRILRDVHTALS--TPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDL 663
Query: 656 S---DLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPN-GRSVSLMD 711
S D +L SP+ +N D +F ++ VQ + ++S +YSE +E + + N G+S+S++D
Sbjct: 664 SGLIDFTRLPSPTPENKDLFFVTRS-SGVQPSPARSSSYSEANEPDLQMANGGKSLSMVD 722
Query: 712 LQDTHA-----------------AQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQS 754
LQD Q A ++ P R T +++ +A++++ +T +
Sbjct: 723 LQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARAT--PVNLAGLATVRRAGQTPT 780
Query: 755 TPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRS 814
TP ++ A +P L PLSFQNPVY + +P P+ DS E S+ S S
Sbjct: 781 TPGTS-------EGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS--S 831
Query: 815 QSNSEDFKLS---GPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIR 871
SNSE+ + G +++ E+ +R E R+ ++ ++ +PRQNS G R
Sbjct: 832 HSNSEELAAAAKLGSFSTAAEELARR--PGELARRQMSLTEKGGQPTVPRQNSAGPQ--R 887
Query: 872 KVDQ-------GGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSS 924
++DQ R + PP+L + S ++ SA+ + V +R RQQSSS
Sbjct: 888 RIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASAS--PDWVGPSTRLRQQSSS 945
Query: 925 SR-ESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLN-NGQYEEDV--------E 974
S+ +SP K RA+ +Q SPV + + ++RTAAW+L N Q ED
Sbjct: 946 SKGDSPELKPRAVHKQG----PSPV---SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHR 998
Query: 975 ETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLED 1034
+ ++ DE AEK ++ L+++LR+S+++LEEYE QE+ QKL+LEY+ARLE+
Sbjct: 999 DRLRSKDELSQAEK---DLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEE 1055
Query: 1035 SEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDS 1094
EERLRRQQE+KD QMK IISRLM+VEEELKKDHAEMQA +D+KQKIIDAQEKRI SLD+
Sbjct: 1056 GEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDA 1115
Query: 1095 ANTRLMSALTQVKE 1108
AN RLMSALTQ+KE
Sbjct: 1116 ANARLMSALTQLKE 1129
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 1166 bits (3016), Expect = 0.0
Identities = 637/1100 (57%), Positives = 801/1100 (72%), Gaps = 79/1100 (7%)
Query: 81 LPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSC 140
+P+LKESRSHESLLSP S VE LDL E V +KP+HSSILGQD+CFEVT SGSKCFSC
Sbjct: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
Query: 141 NSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFAR 200
SA+ERDKWMENLRR V PNKDN RR E++L+LW+IEAKDL KKKY CELCLDD L+AR
Sbjct: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
Query: 201 TTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGR 260
TT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +KKKKK++N+Y+GLV++P ASV GR
Sbjct: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
Query: 261 QFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLE 320
QFVEKWYPV TP P GK GP IRIK+R+QTITILPME YKEFAE +T++Y LC+ LE
Sbjct: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
Query: 321 PVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEE 380
P++S + KEE+A ALVHILQSTG+ KDFLTDL+MSEVDRCG+++ LIFRENT+ATK+IEE
Sbjct: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
Query: 381 YLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIIN 440
YLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS+++L +HQ NLKMCCELAFCKIIN
Sbjct: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
Query: 441 SYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPD 500
SYCVFPRELKEVFASW+Q+C +RG+ DISERLISASLFLRFLCPAIMSPSLFNL+QEYPD
Sbjct: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
Query: 501 DRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNT 560
DRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN FLEHEW M+RFLLEISNP+T+SNT
Sbjct: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
Query: 561 PGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPT 620
GF+GYIDLGRELS LHSLLWE VSQL+ Q+ V+KLGPLPR+L D+ +L+ T
Sbjct: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLE-------QSIVSKLGPLPRILRDVHTALS--T 531
Query: 621 PIQQQLRRFTEHNSSP-NVSGSLSSGLQKIFEDPTDS---DLHKLKSPSQDNTDSYFRGK 676
P QL + S+P + S S+S+GLQK+ + S D +L SP+ +N D +F +
Sbjct: 532 PGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTR 591
Query: 677 TLLLVQQASSQSMTYSEKDERESSLPN-GRSVSLMDLQDTHA-----------------A 718
+ VQ + ++S +YSE +E + + N G+S+S++DLQD
Sbjct: 592 S-SGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDG 650
Query: 719 QVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQP 778
Q A ++ P R T +++ +A++++ +T +TP ++ A +P L P
Sbjct: 651 QAAAAQLVAGWPARAT--PVNLAGLATVRRAGQTPTTPGTS-------EGAPGRPQLLAP 701
Query: 779 LSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLS---GPSNSSMEDFT 835
LSFQNPVY + +P P+ DS E S+ S S SNSE+ + G +++ E+
Sbjct: 702 LSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS--SHSNSEELAAAAKLGSFSTAAEELA 759
Query: 836 KRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ-------GGLGARAKAPPSL 888
+R E R+ ++ ++ +PRQNS G R++DQ R + PP+L
Sbjct: 760 RR--PGELARRQMSLTEKGGQPTVPRQNSAGPQ--RRIDQPPPPPPPPPPAPRGRTPPNL 815
Query: 889 PHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSR-ESPVPKVRAIQRQQTQQVQSP 947
+ S ++ SA+ + V +R RQQSSSS+ +SP K RA+ +Q SP
Sbjct: 816 LSTLQYPRPSSGTLASAS--PDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQG----PSP 869
Query: 948 VDSATMSPVERTAAWVLN-NGQYEEDV--------EETEQNLDEAKHAEKYEQEITKLKE 998
V + + ++RTAAW+L N Q ED + ++ DE AEK ++ L++
Sbjct: 870 V---SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEK---DLAVLQD 923
Query: 999 RLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLM 1058
+LR+S+++LEEYE QE+ QKL+LEY+ARLE+ EERLRRQQE+KD QMK IISRLM
Sbjct: 924 KLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLM 983
Query: 1059 AVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGI 1118
+VEEELKKDHAEMQA +D+KQKIIDAQEKRI SLD+AN RLMSALTQ+KERYSMQ RNGI
Sbjct: 984 SVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKERYSMQARNGI 1043
Query: 1119 SPTNPTKLSITENGEFKNSS 1138
SPTNPTKL ITENGEF+NSS
Sbjct: 1044 SPTNPTKLQITENGEFRNSS 1063
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 967 bits (2500), Expect = 0.0
Identities = 592/1300 (45%), Positives = 787/1300 (60%), Gaps = 205/1300 (15%)
Query: 2 QTPEVPAERSP-----------RRRSISGTSTSEKPNSMDTANTSPFKVP-GFFSKRLKG 49
+T VP E P RR+S+ G K SM+ A +PF+ GF S+RLK
Sbjct: 84 RTVSVPVEGRPHGEHEYHLGRSRRKSVPGG----KQYSMEGAPAAPFRPSQGFLSRRLKS 139
Query: 50 SIKRTKSQSKLDRNTSFR--LPSLRSTD-DRSRGLPKLKESRSHESLLSPCSTVECLDLG 106
SIKRTKSQ KLDR +SFR LP RS D DR+R + KES SHESLLSP S E L+L
Sbjct: 140 SIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELN 199
Query: 107 RGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRR 166
E +KP+HSSILGQ+FCFEVT SG+KCF+C SA+ERDKW+ENL+R V+PNKDN RR
Sbjct: 200 LDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRR 259
Query: 167 AENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKA---DNIFWGEHFEFFSLPP 223
+NVL+LWIIEA++L PKK+Y+CELCLDD L+ARTTSK ++ D +FWGEHFEF +LP
Sbjct: 260 VDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPA 319
Query: 224 LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPN-------- 275
+ ++ +H+Y+D +KK+KKDK YVGLV +P A++ GR F E+WYPV+ PT +
Sbjct: 320 VRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGS 379
Query: 276 ------------KGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVI 323
KGK G P++R+K+R+QT++ILPME YKEFAE+VT++Y MLC+VLEP +
Sbjct: 380 GGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPAL 439
Query: 324 SVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLK 383
+V+ KEE+A ALVHILQSTG+AKDFL+D+ MSEVDR E + LIFRENT+ATK+IEEY++
Sbjct: 440 NVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMR 499
Query: 384 LVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYC 443
L+GQ+YL DA+GEFI+ALYES+ENCEVDP KC++S L +HQ+NL+MCCELA CK++NS+C
Sbjct: 500 LIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHC 559
Query: 444 VFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRT 503
VFPRELKEVFASW+ +C RG++DI++RLISASLFLRFLCPAIMSPSLF LMQEYPD++T
Sbjct: 560 VFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQT 619
Query: 504 SRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGF 563
SRTLTLIAKVIQNLANF+KF +KE+++ FMN+FLE EWG M++FL EISN DT++N+ F
Sbjct: 620 SRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSF 679
Query: 564 DGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQ 623
+GYIDLGRELS LH+LLWEV+ QL K + KLGPLPR+L DI+ +L NP IQ
Sbjct: 680 EGYIDLGRELSTLHALLWEVLPQLSK-------EALLKLGPLPRLLNDISTALRNPN-IQ 731
Query: 624 QQLRRFTEH-----------------------NSSPNVSGSLSSGLQKIFEDPTDSDLHK 660
+Q R +E NSS ++ ++ GL + D+ +
Sbjct: 732 RQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLN------SSMDMAR 785
Query: 661 LKSPSQDN--TDSYFRGKTLLLVQQ----ASSQSMTYSEKD---ERESSLPNGRSVSLMD 711
L SP+++ GK L V + SS + S D + L +SVS++D
Sbjct: 786 LPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLD 845
Query: 712 LQ-DTHAAQVEHASV--MLDVPIRLTGSQLSITQVASIKQL---RETQSTPQSAPQVRRP 765
LQ D ++ +SV + V L SQ S+T ++ R +Q + S
Sbjct: 846 LQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMR 905
Query: 766 LHPALNQPGGLQ------PLSFQNPVYHLNNPIPAMPKASID------------------ 801
L G+ PLSFQNP++H+ P P
Sbjct: 906 LSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHH 965
Query: 802 -----------------SSLENLSTASSR--------SQSNSEDFKLSGPSNSSMEDFTK 836
S E+LS+ + S S S++F GPS + DFT+
Sbjct: 966 HRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF---GPSGT---DFTR 1019
Query: 837 RSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRS 896
R +D + +H + I + R +G GG G PP L S +
Sbjct: 1020 RQLSLQD-NLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGG--GGQPPPLQRGKSQQL 1076
Query: 897 TGSM------SVVSAALVAEPVQNGSRSRQQSSSSRES--------------PVPKVRAI 936
T S S + EP +R RQQS S S P +
Sbjct: 1077 TVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITK- 1135
Query: 937 QRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVE------------ETEQNLDEAK 984
Q QT +P TM ERT AWV N D+E E +++DE++
Sbjct: 1136 QHSQTPSTLNP----TMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESR 1191
Query: 985 --HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQ 1042
++YE+EI LKERL +S+R+LEEYERRLL QE+Q K+L++Y+ARLE SE+RLR+Q
Sbjct: 1192 LDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQ 1251
Query: 1043 QEEKDSQMKSIISRLMAVEEELKKDHAEM-QAVIDAKQKIIDAQEKRIVSLDSANTRLMS 1101
Q EKDSQ+KSII RLM VEEEL++DH M + + + K++++DAQE+++ L N R+
Sbjct: 1252 QAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTL 1311
Query: 1102 ALTQVKERYSMQVRNGI---SPTNPTKLSITENGEFKNSS 1138
A NG+ +P P +L ITENGEF+N++
Sbjct: 1312 A----------PPWNGLAPPAPPPPPRLQITENGEFRNTA 1341
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 431 bits (1109), Expect = e-120
Identities = 268/665 (40%), Positives = 373/665 (56%), Gaps = 54/665 (8%)
Query: 9 ERSPRRRSISGTSTSEKPNSMDTAN-TSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFR 67
E PRR + G+++SE + N P ++PG G + + L R +
Sbjct: 154 EEGPRRPRV-GSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKK 212
Query: 68 LPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCF 127
L D G P SR ESL +T+ LDLG V + PLH S+LG+ CF
Sbjct: 213 KARLEPRD----GPPSALGSR--ESL----ATLSELDLGAERDVRIWPLHPSLLGEPHCF 262
Query: 128 EVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDL------ 181
+VT+ GS+CFSC SA+ERD+W+E+LRR QP +DN R E L +W+ EAK L
Sbjct: 263 QVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAG 322
Query: 182 APKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKK 241
AP + EL LD L ART + +FW E F F +LPP +++ + +
Sbjct: 323 APGVR--AELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRL------RGLG 374
Query: 242 DKNNYVGLVNI-------PTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTIT 294
+ +G V + P A G +E+W+P+ G G ++R + R + +
Sbjct: 375 PGSAVLGRVALALEELDAPRAPAAG---LERWFPLL------GAPAGAALRARIRARRLR 425
Query: 295 ILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 354
+LP E+YKE AEF+T +Y LC LEP + + KEELA A+V +L++TGRA+ +TDL
Sbjct: 426 VLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGT 485
Query: 355 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK 414
+E+ RCG + L+FRENT+ATK+I+EY+KLV Q YL + LG+ ++ L S E+CEVDPSK
Sbjct: 486 AELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSK 545
Query: 415 CSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLIS 474
C +SEL +HQ+ L+ CE F II+SY FP EL VF+SW++ C RG + + RL+
Sbjct: 546 CPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVC 605
Query: 475 ASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMN 534
ASLFLR LCPAI++PSLF L ++P +RTLTLIAKVIQNLAN A FG KE YM FMN
Sbjct: 606 ASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMN 665
Query: 535 DFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSF 594
FLE M+ FL +++ D + G+ G DL +L+VLH+ L + ++LD
Sbjct: 666 SFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELD------ 719
Query: 595 LQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPT 654
Q T L PLP +L I + P + +R V SLS+G + F P
Sbjct: 720 -QTTRDTLEPLPTILRAIEEG--QPVLVSVPMRL---PLPPAQVHSSLSAGEKPGFLAPR 773
Query: 655 DSDLH 659
D H
Sbjct: 774 DLPKH 778
Score = 33.5 bits (75), Expect = 1.2
Identities = 52/222 (23%), Positives = 83/222 (37%), Gaps = 24/222 (10%)
Query: 855 IPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASL--RSTGSMSVVSAALVAEPV 912
+P+ LP AQ+ G AP LP L +S SV + A P
Sbjct: 746 VPMRLPLP----PAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPR 801
Query: 913 QNGSRS-RQQSSSSRESPVPKVRAIQRQQTQQV-QSPVDSATMSPVERTAAWVLNNGQYE 970
+ R R+ R VP R +R+Q+ P S +M P R W ++
Sbjct: 802 PDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLP 861
Query: 971 EDVEET-EQNLDEAKHAEKY---EQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
++ +D+ + + + + KL E + E L +EQ++ L+
Sbjct: 862 RKPSVPWQRQMDQPQDRNQALGTHRPVNKLAEL---------QCEVAALREEQKVLSRLV 912
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDH 1068
E L L QQE+ Q++ + SRL A E +H
Sbjct: 913 E---SLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEH 951
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 178 bits (451), Expect = 3e-44
Identities = 141/491 (28%), Positives = 241/491 (49%), Gaps = 38/491 (7%)
Query: 112 SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 161
SV +H S+ G+ CF++ S+ F+ + + + WM+ L+ R P
Sbjct: 526 SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 585
Query: 162 DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 217
N R R + L L I EA L P K + +C + L+ A+T ++ + N W E F
Sbjct: 586 SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 643
Query: 218 FFSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 276
F LPP ++ ++ + K KK K+ + + + + ++W+ +S+ P K
Sbjct: 644 FDDLPP----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 699
Query: 277 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 336
G G S+R+++R+ I+P E+Y EF E + + L V +++ LA L+
Sbjct: 700 GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 757
Query: 337 HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 396
I L L E+ E L FR T+A+ +E+Y+K Q++H AL +
Sbjct: 758 RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 816
Query: 397 FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 454
I + ES ++CE+ PSK +E ++ L + EL KI + + P L+ ++
Sbjct: 817 SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 875
Query: 455 SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 512
++ ++ + + R++S +FLR +CPAI++P +FN++ + P +RTL L+AK
Sbjct: 876 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 935
Query: 513 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 568
+QNLAN +FG KE YM +N F++ M FL E+ N PDT ++ D
Sbjct: 936 SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 990
Query: 569 LGRELSVLHSL 579
L R+L+ LH +
Sbjct: 991 LSRDLAALHEI 1001
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 178 bits (451), Expect = 3e-44
Identities = 141/491 (28%), Positives = 241/491 (49%), Gaps = 38/491 (7%)
Query: 112 SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 161
SV +H S+ G+ CF++ S+ F+ + + + WM+ L+ R P
Sbjct: 349 SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 408
Query: 162 DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 217
N R R + L L I EA L P K + +C + L+ A+T ++ + N W E F
Sbjct: 409 SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 466
Query: 218 FFSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 276
F LPP ++ ++ + K KK K+ + + + + ++W+ +S+ P K
Sbjct: 467 FDDLPP----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 522
Query: 277 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 336
G G S+R+++R+ I+P E+Y EF E + + L V +++ LA L+
Sbjct: 523 GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 580
Query: 337 HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 396
I L L E+ E L FR T+A+ +E+Y+K Q++H AL +
Sbjct: 581 RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 639
Query: 397 FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 454
I + ES ++CE+ PSK +E ++ L + EL KI + + P L+ ++
Sbjct: 640 SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 698
Query: 455 SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 512
++ ++ + + R++S +FLR +CPAI++P +FN++ + P +RTL L+AK
Sbjct: 699 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 758
Query: 513 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 568
+QNLAN +FG KE YM +N F++ M FL E+ N PDT ++ D
Sbjct: 759 SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 813
Query: 569 LGRELSVLHSL 579
L R+L+ LH +
Sbjct: 814 LSRDLAALHEI 824
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 132 bits (333), Expect = 1e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
Query: 212 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 263
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 156
Query: 264 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 314
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 157 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
Query: 315 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 372
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 274
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 418
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 275 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 334
Query: 419 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 475
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 335 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 394
Query: 476 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 395 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 132 bits (333), Expect = 1e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 212 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 263
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 264 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 314
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 315 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 372
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 418
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 419 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 475
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 476 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 2.6
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 231
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 132 bits (333), Expect = 1e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
Query: 212 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 263
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 156
Query: 264 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 314
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 157 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
Query: 315 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 372
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 274
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 418
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 275 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 334
Query: 419 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 475
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 335 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 394
Query: 476 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 395 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 132 bits (333), Expect = 1e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 212 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 263
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 264 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 314
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 315 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 372
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 418
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 419 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 475
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 476 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 2.6
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 231
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 132 bits (332), Expect = 2e-30
Identities = 114/389 (29%), Positives = 183/389 (47%), Gaps = 42/389 (10%)
Query: 200 RTTSKTKADNIFWGEHFEF-FSLPPLHSITVHI---YKDVEK----------KKKKDKNN 245
+T K K +N + E F F + P +S H +DV+K K +
Sbjct: 182 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE 241
Query: 246 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 301
++G + IP + E WY + P N K+ P S+R+ + + + Y
Sbjct: 242 FLGELRIPLKVLRQSSSYEAWYFLQ-PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY 300
Query: 302 KEFAEFVTSNYTMLCSVLEPVIS---------VRNKEELACALVHILQSTGRAKDFLTDL 352
+ + + + +EPV + R K+E A LV + GR F++ +
Sbjct: 301 SPLRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAI 355
Query: 353 VMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDP 412
+EV R + + IFR N++A+K I+E +KL G YLH L I+ + +S + CE+DP
Sbjct: 356 ASAEVKRTQDPNT-IFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDP 414
Query: 413 SKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISER 471
K E L ++ NL+ + F I S P + ++F S ++ R + D R
Sbjct: 415 VKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVR 474
Query: 472 L--ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN---K 526
+S+ +FLRF PAI+SP+LF L + D +TSRTLTLI+K +Q L + +K + K
Sbjct: 475 YTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFK 534
Query: 527 EEYMAFMNDFLEHE--WGGMKRFLLEISN 553
E YMA +F + +K FL IS+
Sbjct: 535 ESYMATFYEFFNEQKYADAVKNFLDLISS 563
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 132 bits (331), Expect = 2e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 212 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 263
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 264 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 314
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 315 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 372
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 418
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 419 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 475
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 476 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 2.6
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 231
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 132 bits (331), Expect = 2e-30
Identities = 116/406 (28%), Positives = 187/406 (46%), Gaps = 52/406 (12%)
Query: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211
+LR V P CR LR ++EA+DLAPK + D + R +T+ +I
Sbjct: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
Query: 212 -------WGEHFEF-FSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFV 263
W E FEF + ++ V + +N+++G V I + Q
Sbjct: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWD----WDLVSRNDFLGKVVIDVQRLRVVQQE 228
Query: 264 EKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM----- 314
E W+ + P +K + S++++ R + T+LP Y+ + +
Sbjct: 229 EGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 287
Query: 315 --LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENT 372
L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N+
Sbjct: 288 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNS 346
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS-------S 418
+A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS +
Sbjct: 347 LASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEA 406
Query: 419 ELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLISA 475
E+++ + L+ + S P ++ F ++ R G Q + I+
Sbjct: 407 EVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAV 466
Query: 476 SLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519
+ FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 467 TSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
Score = 32.3 bits (72), Expect = 2.6
Identities = 14/56 (25%), Positives = 27/56 (48%)
Query: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 231
+ AKD+ +C + +D+ RT + K FWGE ++ P H++ ++
Sbjct: 17 LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 113 bits (282), Expect = 1e-24
Identities = 91/330 (27%), Positives = 161/330 (48%), Gaps = 22/330 (6%)
Query: 246 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 301
++G + +P + + WY + P N K+ S+R+ + +LP E Y
Sbjct: 268 FLGEIKVPVNVLRTDSSHQAWYLLQ-PRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
Query: 302 KEFAEFVTSNYTM--LCSVLEPVIS--VRNKEELACALVHILQSTGRAKDFLTDLVMSEV 357
+ + + + + ++S R+K + LV +L + F T ++E+
Sbjct: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
Query: 358 DRCGEHDV-LIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 416
D D IFR N++AT+ ++E +K+VG YL L + + +S ++CE+DP K
Sbjct: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
Query: 417 SSELIDH-QSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQD--ISERLI 473
+ +++ + NL+ + F I+ S P + ++F S +Q R D + +
Sbjct: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
Query: 474 SASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANF-----AKFGNKEE 528
S+ +FLRF A++SP F+L +PD +T RTLTLI+K IQ L ++ +K KE
Sbjct: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
Query: 529 YMA-FMNDFLEHEW-GGMKRFLLEISNPDT 556
+M F F E + +K+FL EIS+ +T
Sbjct: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTET 594
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 110 bits (276), Expect = 6e-24
Identities = 107/405 (26%), Positives = 185/405 (45%), Gaps = 46/405 (11%)
Query: 171 LRLWIIEAKDLAPKK------KYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPL 224
LR ++ A+DLAP+ + +L T KT+ + W E E +P
Sbjct: 135 LRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPH--WDEVLELREMPGA 192
Query: 225 HSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSI 284
S + ++ KN+++G+V ++ + + W+ + P P + G ++
Sbjct: 193 PS---PLRVELWDWDMVGKNDFLGMVEFSPKTLQQKP-PKGWFRL-LPFPRAEEDSGGNL 247
Query: 285 ---RIKSRFQTITILPMEQYKEFAEFVTSNY--------TMLCSVLEPVISVRNKEELAC 333
R+K R +LP + Y+ E + + ++LE + +++LA
Sbjct: 248 GALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLAT 307
Query: 334 ALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDA 393
LV + G A FL L EV R + + L FR N++A+KS+E+++KLVG YLH+
Sbjct: 308 KLVKLFLGRGLAGHFLDYLTRREVARTMDPNTL-FRSNSLASKSMEQFMKLVGMPYLHEV 366
Query: 394 LGEFIKALYESDENCEVDPSKC------------SSSELIDHQSNLKMCCEL---AFCKI 438
L I ++E + E+DP K + SE +++L + I
Sbjct: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426
Query: 439 INSYCVFPRELKEVFASWKQQCLNR----GKQDISERLISASLFLRFLCPAIMSPSLFNL 494
+ S P ++ F ++ R QD+ IS LFLRF PAI++P LF+L
Sbjct: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486
Query: 495 MQEYPDDRTSRTLTLIAKVIQNLANFAK--FGNKEEYMAFMNDFL 537
++ D +TSR+L L+AK +Q++ N + KE +MA ++ FL
Sbjct: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFL 531
Score = 33.9 bits (76), Expect = 0.90
Identities = 19/101 (18%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Query: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDV 235
+ AKD++ +C + +DD + ART + ++ FWGE + H + ++ +
Sbjct: 17 LPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDE- 75
Query: 236 EKKKKKDKNNYVGLVNIPTASVTG-RQFVEKWYPVSTPTPN 275
++ +G +++ ++T + ++ W +S P+
Sbjct: 76 ---DTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPD 113
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 108 bits (270), Expect = 3e-23
Identities = 88/293 (30%), Positives = 143/293 (48%), Gaps = 14/293 (4%)
Query: 299 EQYKEFAEFVT----SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 354
++++ E VT + L V+ +ELA LV + S L ++
Sbjct: 1203 DRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS 1262
Query: 355 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE----NCEV 410
EV+ L FR N++A+K + K+ G YL L ++ + S + + EV
Sbjct: 1263 KEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
Query: 411 DPSKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS 469
DP++ SE L ++Q NL E F II+S FP +L+ V Q R Q+ S
Sbjct: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-S 1380
Query: 470 ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEY 529
+ +++FLRF+ PAI+SP ++ + P R R L L++K++Q++AN F KEE+
Sbjct: 1381 IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEH 1439
Query: 530 MAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFD-GYIDLGRELSVLHSLLW 581
M NDF++ + +RF L+I++ S+ +I G L+ LH LLW
Sbjct: 1440 MRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLA-LHRLLW 1491
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 103 bits (258), Expect = 7e-22
Identities = 89/313 (28%), Positives = 148/313 (47%), Gaps = 33/313 (10%)
Query: 299 EQYKEFAEFVT----SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 354
++++ E VT + L V+ +ELA LV + S L ++
Sbjct: 1203 DRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS 1262
Query: 355 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE----NCEV 410
EV+ L FR N++A+K + K+ G YL L ++ + S + + EV
Sbjct: 1263 KEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
Query: 411 DPSKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEV----FASWKQQCLNRG- 464
DP++ SE L ++Q NL E F II+S FP +L+ V + + LN+
Sbjct: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKAT 1381
Query: 465 --------KQDISERL-------ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTL 509
K +S+R + +++FLRF+ PAI+SP ++ + P R R L L
Sbjct: 1382 VKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKL 1441
Query: 510 IAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFD-GYID 568
++K++Q++AN F KEE+M NDF++ + +RF L+I++ S+ +I
Sbjct: 1442 MSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFIS 1500
Query: 569 LGRELSVLHSLLW 581
G L+ LH LLW
Sbjct: 1501 DGNVLA-LHRLLW 1512
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 61.2 bits (147), Expect = 5e-09
Identities = 52/184 (28%), Positives = 81/184 (44%), Gaps = 20/184 (10%)
Query: 916 SRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEED--- 972
++ + E PK +I Q V+ V+ T E T L NGQ +
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQ---VEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 973 -VEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR 1031
EE EQ DE H EK E+E KER RLE ER + EQ K + + +AR
Sbjct: 240 QEEEREQGSDEISHHEKMEEED---KERAEAERARLEAEERERIKAEQ--DKKIADERAR 294
Query: 1032 LEDSE-----ERLRRQQEEKD---SQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIID 1083
+E E ER RR+ EE++ + K ++EE K+ E Q + + +++ +
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
Query: 1084 AQEK 1087
+++
Sbjct: 355 ERQR 358
Score = 40.0 bits (92), Expect = 0.013
Identities = 65/363 (17%), Positives = 142/363 (39%), Gaps = 33/363 (9%)
Query: 801 DSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALP 860
D++ + +S+S E +++ + + + + K + + +++ P
Sbjct: 140 DTAENETTEKEEKSESRQERYEIE-ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKP 198
Query: 861 RQNSTGQAQIR-KVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSR 919
++ S G+ Q+ V++ ++ + + + S ++ + + +
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKME 258
Query: 920 QQSSSSRESPVPKVRAIQRQQTQQVQSPV---DSATMSPVERTAAWVLNNGQYEED---- 972
++ E+ ++ A +R++ + Q + A + E+ AA + EE
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318
Query: 973 ------VEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
EE ++ +E K A + Q I + ++R +R++E E+R +E+Q +
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA-AEERQRARAEE 377
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEE--------ELKKDHAEMQAVIDAK 1078
E KA++E E++ +Q EEK M+ + VE+ E K ++Q + K
Sbjct: 378 EEKAKVE--EQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKK 435
Query: 1079 Q---KIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITE----N 1131
Q K Q KR + T + K + + + + K TE N
Sbjct: 436 QGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQN 495
Query: 1132 GEF 1134
GEF
Sbjct: 496 GEF 498
Score = 36.6 bits (83), Expect = 0.14
Identities = 34/167 (20%), Positives = 76/167 (45%), Gaps = 17/167 (10%)
Query: 975 ETEQNLDEAKH--AEKYEQEITKLKERLRVSSRRLEEY-----ERRLLVQEQQMQKLLLE 1027
E + L+E + E +E KLK++ + ++ LEE ERR +++E++ ++ E
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE 590
Query: 1028 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV--------IDAKQ 1079
+L + EE+ R ++E + + ++ R E+ L D + I+ +
Sbjct: 591 ADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 650
Query: 1080 KIIDAQEKRIVSLDSAN-TRLMSALTQVKERYSMQVRNGISPTNPTK 1125
+ ++ ++ + S + ++S + E+Y+ + G PTK
Sbjct: 651 EFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAI-EGTKSAKPTK 696
Score = 32.0 bits (71), Expect = 3.4
Identities = 24/80 (30%), Positives = 39/80 (48%), Gaps = 6/80 (7%)
Query: 971 EDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKA 1030
E+ E+ +Q EA E+ +LK++ + LEE E+R +E + E K
Sbjct: 549 EEFEKLKQKQQEAA------LELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKR 602
Query: 1031 RLEDSEERLRRQQEEKDSQM 1050
RL++ ER R + EK +M
Sbjct: 603 RLKEEIERRRAEAAEKRQKM 622
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 58.5 bits (140), Expect = 3e-08
Identities = 48/168 (28%), Positives = 85/168 (50%), Gaps = 15/168 (8%)
Query: 932 KVRAIQRQQTQQVQSPVDSA---TMSPVERTAAWVLNNGQYEEDVEETEQNL-DEAKHAE 987
KV +Q +T ++ ++S + VE L N + EE + E E+ L ++ +
Sbjct: 158 KVEQLQ-DETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLR 216
Query: 988 KYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKLLLEYKARLEDSEERLRRQQE 1044
+ E+ + + +ERLR RL E E RL QE+++ ++ L E + RL + EERLR Q+E
Sbjct: 217 EQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEE 276
Query: 1045 EKDSQMKSIISRLMAVEEELKKDH---AEMQAVIDAKQKIIDAQEKRI 1089
Q + RL EE L++ E + + +++ + QE+R+
Sbjct: 277 RLHEQEE----RLCEQEERLREQEERLCEQEERLREQEERLCEQEERL 320
Score = 45.1 bits (105), Expect = 4e-04
Identities = 34/128 (26%), Positives = 70/128 (54%), Gaps = 10/128 (7%)
Query: 968 QYEEDVEETEQNL-DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QK 1023
+ EE + E E+ L ++ + + E+ + + +ERL RL E E RL QE+++ ++
Sbjct: 245 EQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEE 304
Query: 1024 LLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEE-----ELKKDHAEMQAVIDAK 1078
L E + RL + EERL R+QEE+ + + + + +EE E ++ E + +++ +
Sbjct: 305 RLREQEERLCEQEERL-REQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERE 363
Query: 1079 QKIIDAQE 1086
+ + + +E
Sbjct: 364 RLLEEVEE 371
Score = 43.5 bits (101), Expect = 0.001
Identities = 33/111 (29%), Positives = 60/111 (54%), Gaps = 8/111 (7%)
Query: 968 QYEEDVEETEQNL-DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM--QKL 1024
+ EE + E E+ L ++ + + E+ + + +ERLR RL E E RL QE+++ Q+
Sbjct: 273 EQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEK 332
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISR---LMAVEEELKKDHAEMQ 1072
L + LE+ E+ L +QE + + + ++ R L VEE L+++ Q
Sbjct: 333 LPGQERLLEEVEKLL--EQERRQEEQERLLERERLLEEVEELLEQERLRQQ 381
Score = 42.4 bits (98), Expect = 0.003
Identities = 37/106 (34%), Positives = 59/106 (55%), Gaps = 9/106 (8%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQE--QQMQKLL 1025
+ EE + E E+ L E + + ++E +E+L R LEE E +LL QE Q+ Q+ L
Sbjct: 301 EQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVE-KLLEQERRQEEQERL 359
Query: 1026 LEYKARLEDSEERLR----RQQEEKDSQMKSI--ISRLMAVEEELK 1065
LE + LE+ EE L RQQ+E+ Q +++ + RL +E L+
Sbjct: 360 LERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLE 405
>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
sapiens]
Length = 1575
Score = 58.2 bits (139), Expect = 4e-08
Identities = 64/268 (23%), Positives = 111/268 (41%), Gaps = 27/268 (10%)
Query: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYE-SDENCEVDPSKCSSSELIDHQSNLKMCC 431
I T +E Y V Q L GE K Y+ + E P ++L NL+
Sbjct: 1000 INTNPVEVYKAWVNQ--LETQTGEASKLPYDVTTEQALTYPEV--KNKLEASIENLRRVT 1055
Query: 432 ELAFCKIINSYCVFPRELKEVFASWKQQCLNR---GKQDISERLISASLFLRFLCPAIMS 488
+ II+S + P L+ + K + +D +++ L+ R++ PAI++
Sbjct: 1056 DKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVA 1115
Query: 489 PSLFNLM------QEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 542
P F+++ Q D R R L +AKV+Q+ A+ F + E+++ MN++L +
Sbjct: 1116 PDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQ 1173
Query: 543 GMKRFLLEISNPDTISNTPGFDGYIDLG-----------RELSVLHSLLWEVVSQLDKGE 591
+++ E N D Y DL E+ HSLL E + +
Sbjct: 1174 EFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEK 1233
Query: 592 NSFLQATVAKLGPLPRVLADITKSLTNP 619
N L + LG +P V + + + +P
Sbjct: 1234 NDLLSELLGSLGEVPTVESFLGEGAVDP 1261
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
Length = 570
Score = 55.5 bits (132), Expect = 3e-07
Identities = 37/190 (19%), Positives = 94/190 (49%), Gaps = 14/190 (7%)
Query: 910 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY 969
E + + R+Q +E K+R +++Q Q+ + + E Q
Sbjct: 351 EKMHEQEKIREQEEKRQEEE--KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 970 EEDV--EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL--- 1024
+E+ E+ E+ ++ + ++ E+++ + +E++R +++ E E ++ QE+ MQ+
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Query: 1025 -------LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDA 1077
+ E +A++++ EE++RRQ+E+ Q K I + + E+ + + + + +
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 528
Query: 1078 KQKIIDAQEK 1087
++K+ + +EK
Sbjct: 529 EEKMCEQEEK 538
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/131 (22%), Positives = 68/131 (51%), Gaps = 9/131 (6%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKL 1024
Q EE + E E+ ++ + E++I + +E++R ++E E ++ QE++M ++
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426
Query: 1025 LLEYKARLEDSEERLR------RQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAK 1078
+ E + ++ EE++R R+QEEK + + ++ E + E +A + +
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486
Query: 1079 QKIIDAQEKRI 1089
++ + QE++I
Sbjct: 487 EEKMRRQEEKI 497
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/111 (26%), Positives = 62/111 (55%), Gaps = 17/111 (15%)
Query: 968 QYEEDVEETEQNL--DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL- 1024
+ EE + E E + EAK E+ E+++ + +E++R +++ E E ++ QE+ MQ+
Sbjct: 464 EQEEKMGEQEGKMCEQEAKMQEQ-EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 522
Query: 1025 ---------LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1066
+ E + ++++ EE++RRQ+E +M+ RL EE++++
Sbjct: 523 EKMWEQEEKMCEQEEKMQEQEEKMRRQEE----KMREQEVRLRQQEEKMQE 569
Score = 40.8 bits (94), Expect = 0.007
Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 19/195 (9%)
Query: 903 VSAALVAEPVQNG--SRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTA 960
VSA L A+ +N +R QQ K++ + + +Q + + +
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM 324
Query: 961 AWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQ 1020
W + EE + E+ + E E++I +L+E++ + E+ E+R ++ +
Sbjct: 325 MW-----EKEEKMRRQEEMMWEK------EEKIRELEEKMHEQEKIREQEEKRQEEEKIR 373
Query: 1021 MQKLLLEYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ---AV 1074
Q+ E +A++ EE++R Q+E E++ M+ ++ EE++ + EMQ
Sbjct: 374 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEK 433
Query: 1075 IDAKQKIIDAQEKRI 1089
+ +++ I QEK+I
Sbjct: 434 MRRQEEKIREQEKKI 448
Score = 40.0 bits (92), Expect = 0.013
Identities = 27/129 (20%), Positives = 73/129 (56%), Gaps = 11/129 (8%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKLLL 1026
EE + E E+ + E + + E++ + +E++R +R +E E ++ QE+++ ++ +
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKRQE-EEKIREQEKR-QEQEAKMWRQEEKIREQEEKIR 400
Query: 1027 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELK---KDHAEMQAVIDAKQK 1080
E + +++ EE++ Q+E E++ +M+ ++ EE+++ K E + I +++
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 1081 IIDAQEKRI 1089
++ QE+++
Sbjct: 461 MMQEQEEKM 469
Score = 37.7 bits (86), Expect = 0.063
Identities = 30/175 (17%), Positives = 81/175 (46%), Gaps = 26/175 (14%)
Query: 919 RQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQ 978
RQ+ + K+R + + +Q + + + W + EE+++E E+
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW-----EQEEEMQEQEE 432
Query: 979 NLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL------------LVQEQQ----- 1020
+ + + + E++I + +E++R ++E E ++ +QEQ+
Sbjct: 433 KMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRR 492
Query: 1021 MQKLLLEYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
++ + E + ++ + EE++R Q+E E++ +M ++ EE++++ +M+
Sbjct: 493 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 547
Score = 32.0 bits (71), Expect = 3.4
Identities = 37/172 (21%), Positives = 79/172 (45%), Gaps = 33/172 (19%)
Query: 975 ETEQNLD----EAKHAEKYEQEITKLK--------------ERLRVSSRRLEEYERRLLV 1016
E EQ L + K A++Y +E+TK + E L+ + +L+E + +
Sbjct: 164 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 223
Query: 1017 QEQQMQKLLLEYKARLEDSEERLRRQQEEKDS-----QMKSIISRLMAVEEE------LK 1065
++ ++Q + E K +LE ++ L +QQ + ++ +++S+ ++L A EE L
Sbjct: 224 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 283
Query: 1066 KDHAE----MQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQ 1113
+ E + I +++ I QE++I + R + + +E+ Q
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 335
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 55.5 bits (132), Expect = 3e-07
Identities = 42/159 (26%), Positives = 79/159 (49%), Gaps = 6/159 (3%)
Query: 932 KVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQ 991
K+ A +Q+ ++ QS ++S+ + YEE +E E E K+ + +
Sbjct: 1453 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ---E 1509
Query: 992 EITKLKERLRVSSRRLEEYER---RLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDS 1048
EI+ L E+L + + E E+ +L V++ ++Q L E +A LE E ++ R Q E +
Sbjct: 1510 EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569
Query: 1049 QMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
I +L +EE+++ Q V+D+ Q +DA+ +
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608
Score = 41.6 bits (96), Expect = 0.004
Identities = 40/172 (23%), Positives = 73/172 (42%), Gaps = 11/172 (6%)
Query: 973 VEETEQNLDEAKHAE-KYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR 1031
+EE E+ L+ + A K E+ + L L S RLEE VQ + +K E++
Sbjct: 1117 IEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKM 1176
Query: 1032 LEDSEER----------LRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKI 1081
D EE LR++ + +++ I L V+++L+K+ +E + +D
Sbjct: 1177 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 1082 IDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGE 1133
++ K +L+ + L + + + R+ T TENGE
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Score = 41.2 bits (95), Expect = 0.006
Identities = 57/271 (21%), Positives = 116/271 (42%), Gaps = 44/271 (16%)
Query: 833 DFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ---GGLGARAKAPPSLP 889
D +++++ ED ++ + L L ++ QA+I ++++ ARAK
Sbjct: 1088 DINQQNSKIED--------EQVLALQLQKKLKENQARIEELEEELEAERTARAKVE---- 1135
Query: 890 HSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVD 949
LRS S + + E + + + + RE+ K+R + T Q ++
Sbjct: 1136 ---KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 950 SATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYE--------QEITKLKERLR 1001
+ ++ A V G+ ++++ +Q L++ K K E ++I K K L
Sbjct: 1193 ALR----KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1248
Query: 1002 VSSRRLEEYERRLLVQEQQMQKLLLEY---KARLEDSEERLRRQQEEKDSQMKSIISRLM 1058
SR LE+ V+ ++ Q+ L ++ +A+L+ L RQ EEK++ + + +
Sbjct: 1249 KVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKL 1308
Query: 1059 A-----------VEEELKKDHAEMQAVIDAK 1078
+ +EEE K +A A+ A+
Sbjct: 1309 SYTQQMEDLKRQLEEEGKAKNALAHALQSAR 1339
Score = 38.9 bits (89), Expect = 0.028
Identities = 63/341 (18%), Positives = 123/341 (36%), Gaps = 47/341 (13%)
Query: 798 ASIDSSLENLSTASSRSQSNSEDFKLS-GPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP 856
A + ++NL + + +FKL S+ME K E SR T+ D+
Sbjct: 1203 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR--TLEDQANE 1260
Query: 857 LALPRQNS-------TGQAQIRKVDQGGLGARAKAPPSLPHSAS---LRSTGSMSVVSAA 906
+ + + T Q + + G L + + +L + L T M +
Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ 1320
Query: 907 LVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNN 966
L E + + S+ + + + Q ++ + ++ + A W
Sbjct: 1321 LEEEGKAKNALAHALQSARHDCDLLRE---QYEEETEAKAELQRVLSKANSEVAQW---R 1374
Query: 967 GQYEEDVEETEQNLDEAKH--------AEKYEQEITKLKERLRVSSRRLEEYERRLLV-- 1016
+YE D + + L+EAK AE+ + + L + RL+ L+V
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434
Query: 1017 ------------QEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEEL 1064
+++ K+L E+K + E+S+ L Q+E S + A EE L
Sbjct: 1435 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1494
Query: 1065 ------KKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRL 1099
K+++ +Q I + + K + L+ +L
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Score = 38.5 bits (88), Expect = 0.037
Identities = 37/160 (23%), Positives = 74/160 (46%), Gaps = 24/160 (15%)
Query: 978 QNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKAR---LED 1034
++ + K ++E ++KE L S R +E E +++ Q+ L L+ +A L D
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 1035 SEER---LRRQQEEKDSQMKSIISRLMAVEE-----------------ELKKDHAEMQAV 1074
+EER L + + + ++++K + RL EE ELKKD +++
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 1075 IDAKQKIIDAQEKRIVSLDSANTRLMSALTQV-KERYSMQ 1113
+ +K A E ++ +L L + ++ KE+ ++Q
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Score = 35.8 bits (81), Expect = 0.24
Identities = 50/238 (21%), Positives = 108/238 (45%), Gaps = 27/238 (11%)
Query: 859 LPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRS 918
L QN++ Q +K++ +++ ++ + ++ AA++AE ++
Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK----- 1772
Query: 919 RQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQ 978
++Q +S+ + +++ Q + +Q +D A ++ + + E V E E
Sbjct: 1773 KEQDTSAH---LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ---KLEARVRELEG 1826
Query: 979 NLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE---YKARLED 1034
L+ E K + + + K + R++ + + EE ++ LL + + KL L+ YK + E+
Sbjct: 1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEE 1886
Query: 1035 SEE-------RLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1085
+EE + R+ Q E D + R E ++ K A+ + I AKQK+ D +
Sbjct: 1887 AEEQANTNLSKFRKVQHELDEAEE----RADIAESQVNKLRAKSRD-IGAKQKMHDEE 1939
Score = 35.4 bits (80), Expect = 0.31
Identities = 42/203 (20%), Positives = 92/203 (45%), Gaps = 10/203 (4%)
Query: 918 SRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ--YEEDVEE 975
+ QQ+ + KV ++ + + + Q D E+ L + E D++
Sbjct: 1004 AHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL 1063
Query: 976 TEQNLDEAKHAEKYEQEITKLKE-RLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLED 1034
T++++ + ++ + +E K KE + + ++E+ + V Q+QK L E +AR+E+
Sbjct: 1064 TQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQ----VLALQLQKKLKENQARIEE 1119
Query: 1035 SEERL--RRQQEEKDSQMKSIISR-LMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVS 1091
EE L R K +++S +SR L + E L++ I+ +K +K
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179
Query: 1092 LDSANTRLMSALTQVKERYSMQV 1114
L+ A + + ++++++ V
Sbjct: 1180 LEEATLQHEATAAALRKKHADSV 1202
Score = 34.3 bits (77), Expect = 0.69
Identities = 43/193 (22%), Positives = 91/193 (47%), Gaps = 29/193 (15%)
Query: 953 MSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYER 1012
M +R V+++ Q D E +N + + +K E ++ +++ +L ++R E ++
Sbjct: 1585 MEQAKRNHQRVVDSLQTSLDAETRSRN-EVLRVKKKMEGDLNEMEIQLSHANRMAAEAQK 1643
Query: 1013 RLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
Q + +Q LL + + +L+D+ R ++ + + R ++ EL+ E++
Sbjct: 1644 ----QVKSLQSLLKDTQIQLDDAV----RANDDLKENIAIVERRNNLLQAELE----ELR 1691
Query: 1073 AVID--------AKQKIIDAQEKRIVSLDSANTRLM-------SALTQVKERYSMQVRNG 1117
AV++ A+Q++I+ E R+ L S NT L+ S LTQ++ V+
Sbjct: 1692 AVVEQTERSRKLAEQELIETSE-RVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 1118 ISPTNPTKLSITE 1130
+ K +IT+
Sbjct: 1751 RNAEEKAKKAITD 1763
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 436
Score = 55.1 bits (131), Expect = 4e-07
Identities = 31/111 (27%), Positives = 63/111 (56%), Gaps = 6/111 (5%)
Query: 967 GQYEEDVEETEQNLDEAKH-AEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM--QK 1023
G+ EE + + E+ + E + +K E+++ K +E++R ++ E E ++ QE+QM QK
Sbjct: 223 GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQK 282
Query: 1024 LLLEYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEM 1071
E + + + EE++R Q+E E++ QM+ ++ EE++ K +M
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQM 333
Score = 48.5 bits (114), Expect = 4e-05
Identities = 33/169 (19%), Positives = 81/169 (47%), Gaps = 14/169 (8%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
+ +++ +E + K +Q +QVQ + E+ + EE + E
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ-EEQVQKQEEQMRKQEEQMREQEEQMREQ 274
Query: 977 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM----------QKLLL 1026
E+ + + K + E++ + +E++R ++ E E ++ QE+QM ++ +
Sbjct: 275 EEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMW 334
Query: 1027 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
E K ++ + +E++ +Q+E E++ QM+ ++ EE+++K +M+
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMR 383
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/158 (19%), Positives = 80/158 (50%), Gaps = 8/158 (5%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
+ +++ +E + K R+Q +Q++ + + E+T Q E+ E+
Sbjct: 244 QKQEEQVQKQEEQMRKQEEQMREQEEQMREQ-EEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 977 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL---LLEYKARLE 1033
EQ ++ + + E+++ + +E++ ++ E + ++ Q++QM K + E + +++
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEM 1071
EE++R+Q+E QM+ ++ EE+++K +M
Sbjct: 363 KQEEQVRKQEE----QMRKQEEQMRKQEEQMRKQEEQM 396
Score = 45.8 bits (107), Expect = 2e-04
Identities = 24/99 (24%), Positives = 55/99 (55%), Gaps = 4/99 (4%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1033
E+ EQ ++ + +K E+++ + +E++R ++ E E ++ QE+Q+QK + ++
Sbjct: 203 EQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK----QEEQMR 258
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
EE++R Q+E+ Q + ++ + E+E + E Q
Sbjct: 259 KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Score = 45.1 bits (105), Expect = 4e-04
Identities = 28/147 (19%), Positives = 69/147 (46%), Gaps = 8/147 (5%)
Query: 910 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY 969
E + ++ +Q RE ++R + Q +Q + + + W +
Sbjct: 283 EQTEQEEQTGEQEEQMREQE-EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMW 341
Query: 970 EEDVE---ETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
E+ + + EQ ++ + +K E+++ K +E++R ++ + E ++ QE+QM
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG---- 397
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSI 1053
E K ++ + +E++R Q+E+ Q + +
Sbjct: 398 EQKEQMGEQKEQMREQEEQMGEQKEQM 424
Score = 43.9 bits (102), Expect = 9e-04
Identities = 25/119 (21%), Positives = 66/119 (55%), Gaps = 13/119 (10%)
Query: 967 GQYEEDVEETEQNLD-EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQK-- 1023
G+ EE + E E+ + + + + E+++ K +E++ ++++ E ++ QE+QM+K
Sbjct: 202 GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 1024 -LLLEYKARLEDSEERLRRQQE---------EKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
+ E + ++ + EE++ +Q+E E++ QM+ ++ EE++++ +M+
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320
Score = 40.4 bits (93), Expect = 0.010
Identities = 27/134 (20%), Positives = 67/134 (50%), Gaps = 8/134 (5%)
Query: 919 RQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNN--GQYEEDVEET 976
R+Q RE ++R + Q +Q + + ++ W G+ EE +++
Sbjct: 306 REQEEQMREQE-EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 977 EQNL-DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDS 1035
E+ + + + K E+++ K +E++R ++ E + ++ Q++QM+ E + ++ +
Sbjct: 365 EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR----EQEEQMGEQ 420
Query: 1036 EERLRRQQEEKDSQ 1049
+E++R+Q+E Q
Sbjct: 421 KEQMRKQEEHMGEQ 434
Score = 39.7 bits (91), Expect = 0.016
Identities = 26/128 (20%), Positives = 71/128 (55%), Gaps = 15/128 (11%)
Query: 967 GQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
G+ E + E E+ + E E+++ K +E++ ++ + E ++ QE+Q+QK
Sbjct: 195 GEQEGQMGEQEEQMGEQ------EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK--- 245
Query: 1027 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDH--AEMQAVIDAKQKI 1081
+ +++ EE++R+Q+E E++ QM+ +++ +E+ +++ E + + +++
Sbjct: 246 -QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 1082 IDAQEKRI 1089
+ QE+++
Sbjct: 305 MREQEEQM 312
Score = 38.9 bits (89), Expect = 0.028
Identities = 25/109 (22%), Positives = 59/109 (54%), Gaps = 8/109 (7%)
Query: 968 QYEEDVEETEQNLDEAK-HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
+ E V E E + E + + E ++ + + ++ ++ E E ++ QE+QMQK
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQK--- 217
Query: 1027 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
+ ++ + EE++R+Q+E E++ Q++ ++ EE+++K +M+
Sbjct: 218 -QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Score = 36.2 bits (82), Expect = 0.18
Identities = 27/125 (21%), Positives = 67/125 (53%), Gaps = 13/125 (10%)
Query: 968 QYEEDVEETEQNLDEAK-HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
+ E V E E + E + + E ++ + +E++ ++++ E ++ QE+QM+K
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK--- 231
Query: 1027 EYKARLEDSEERLRRQQEE---KDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIID 1083
+ ++ + EE++++Q+E+ ++ QM+ ++ EE++++ +M KQK
Sbjct: 232 -QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM-----LKQKEQT 285
Query: 1084 AQEKR 1088
QE++
Sbjct: 286 EQEEQ 290
Score = 33.9 bits (76), Expect = 0.90
Identities = 28/149 (18%), Positives = 69/149 (46%), Gaps = 9/149 (6%)
Query: 968 QYEEDVEETEQNLDEAK-HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
+ E V E E + E + + E ++ + + ++R ++ E E ++ QE QM
Sbjct: 140 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG---- 195
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1086
E + ++ + EE++ Q+E+ Q + + + EE+++K +M + QK + +
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ----EEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Query: 1087 KRIVSLDSANTRLMSALTQVKERYSMQVR 1115
K+ + ++ Q++E+ ++
Sbjct: 252 KQEEQMRKQEEQMREQEEQMREQEEQMLK 280
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 54.7 bits (130), Expect = 5e-07
Identities = 40/166 (24%), Positives = 86/166 (51%), Gaps = 17/166 (10%)
Query: 929 PVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEK 988
P +++A +++QS V + + VE W N Q EE + E+ + E
Sbjct: 259 PQQQLQAEADHLGKELQS-VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE------ 311
Query: 989 YEQEITKLKERLRVSSRRLEEYERRLLVQEQQM---QKLLLEYKARLEDSEERLRRQQE- 1044
+E++I + +E++R ++ E E ++ QE+ M ++ + + + + EE++RRQ+E
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 371
Query: 1045 --EKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKR 1088
EK+ +M+ + EE+++ E++ + ++KI + +EKR
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIR----ELEEKMHEQEKIREQEEKR 413
Score = 47.8 bits (112), Expect = 6e-05
Identities = 30/159 (18%), Positives = 78/159 (49%), Gaps = 7/159 (4%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
R +++ +E + K R+Q +++Q + + + Q E+ E+
Sbjct: 594 REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE 653
Query: 977 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE 1036
E+ ++ + ++ E+ + + +E++R +++ E E ++ QE+ MQ E + ++ + E
Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ----EQEEKMWEQE 709
Query: 1037 ERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQ 1072
E++ Q+E E++ +M+ ++ E L++ +MQ
Sbjct: 710 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/151 (18%), Positives = 77/151 (50%), Gaps = 3/151 (1%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQE---QQMQKL 1024
Q E+ E+ E+ ++ + K E++I + +E+++ ++ E E ++ QE Q+ ++
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
+ E + ++ + EE+++ Q+E Q + I + + E+ +K + + + + ++K+ +
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 1085 QEKRIVSLDSANTRLMSALTQVKERYSMQVR 1115
+EK + + Q ++ + +VR
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Score = 43.5 bits (101), Expect = 0.001
Identities = 26/118 (22%), Positives = 63/118 (53%), Gaps = 5/118 (4%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1029
EE + E E+ +E K E+ E ++ + +E++R ++ E ++ QE++ Q E +
Sbjct: 550 EEKMHEQEKIWEEEKRQEQ-EDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ----EQE 604
Query: 1030 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
++ EE++R Q+E+ Q + I + + E+ + + + + + ++K+ + +EK
Sbjct: 605 EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 662
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/129 (20%), Positives = 71/129 (55%), Gaps = 11/129 (8%)
Query: 968 QYEEDVEETEQNLDEAKHA-EKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLL 1026
+ EE V E+ + E + ++ E+++ K +E++R +++E E ++ QE++++
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR---- 636
Query: 1027 EYKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELK---KDHAEMQAVIDAKQK 1080
E + ++ EE++ Q+E E++ +M+ + EE+++ K E + I +++
Sbjct: 637 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEE 696
Query: 1081 IIDAQEKRI 1089
++ QE+++
Sbjct: 697 MMQEQEEKM 705
Score = 38.9 bits (89), Expect = 0.028
Identities = 28/174 (16%), Positives = 81/174 (46%), Gaps = 3/174 (1%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
R +++ +E + + I+ ++ +Q Q + E+ W +E++ +
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 977 EQNLDEAKHAEKY---EQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1033
+Q + EK E++I + +E++ ++ E E +E+ ++ + + + +
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQ 566
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
+ E+++ RQ+E+ Q + + + + E+ +K + + + ++KI + +EK
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Score = 38.5 bits (88), Expect = 0.037
Identities = 22/97 (22%), Positives = 50/97 (51%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1029
EE + E E+ + E + ++E +E++R +R E+ E ++ Q+ + K
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 1030 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1066
++ + EE++R+Q+E+ Q + I + + E+ +K
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Score = 37.4 bits (85), Expect = 0.082
Identities = 23/123 (18%), Positives = 65/123 (52%), Gaps = 12/123 (9%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1027
+ EE + E E+ + + + ++E+ + +E++ + EE +R Q+ + +
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR------QEQEDKMWR 574
Query: 1028 YKARLEDSEERLRRQQE---EKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
+ ++ + EE++ RQ+E E++ + + ++ EE++++ ++Q + ++KI +
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ---EQEEKIREQ 631
Query: 1085 QEK 1087
+EK
Sbjct: 632 EEK 634
Score = 36.2 bits (82), Expect = 0.18
Identities = 37/185 (20%), Positives = 81/185 (43%), Gaps = 9/185 (4%)
Query: 910 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNG-- 967
E +Q Q+ K+R + + +Q + + + W
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 968 QYEEDVEETEQNL--DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLL 1025
+ EE + E E+ + E EK E++I +L+E++ + E+ E+R ++ + Q+
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR 425
Query: 1026 LEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELK----KDHAEMQAVIDAKQKI 1081
E +A++ EE++R Q+E+ Q K + + + E+ K + E + + ++KI
Sbjct: 426 QEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485
Query: 1082 IDAQE 1086
+ +E
Sbjct: 486 HEQEE 490
Score = 35.4 bits (80), Expect = 0.31
Identities = 24/137 (17%), Positives = 66/137 (48%), Gaps = 20/137 (14%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQM--QKLLLE 1027
+E+ + E+ + E + ++ E ++ + +E++R ++ E E+++ QE+++ Q+ + E
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 468
Query: 1028 YKARLEDSE------------------ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHA 1069
+ R E E E++ Q+E+ Q + + + + E+ +K
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 1070 EMQAVIDAKQKIIDAQE 1086
+ + + ++KI + +E
Sbjct: 529 QEEKMWRQEEKIREQEE 545
Score = 34.7 bits (78), Expect = 0.53
Identities = 31/158 (19%), Positives = 75/158 (47%), Gaps = 29/158 (18%)
Query: 957 ERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEIT-KLKERLRVSSRRLEEYERRLL 1015
E+ W + EE + E E+ + E + + ++E+ + +E++R + E E ++
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 1016 VQEQQM----------QKLLLEYKARLEDSEERL-----------RRQQEEK---DSQMK 1051
QE+ M ++++ E + ++ + EE++ +RQ+EEK + +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 1052 SIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1089
+++ EE+++ E + I ++K + QE++I
Sbjct: 427 EQEAKMWRQEEKIR----EQEEKIREQEKKMWRQEEKI 460
Score = 33.1 bits (74), Expect = 1.5
Identities = 30/129 (23%), Positives = 65/129 (50%), Gaps = 21/129 (16%)
Query: 972 DVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQ--------- 1022
D E E+N + + E E ++++ ++ R+LE +LL+ +QQ+Q
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER--AKLLLPQQQLQAEADHLGKE 273
Query: 1023 --KLLLEYKARLEDSE--ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAK 1078
+ + +A++E++E RL +QQEEK + + ++E +K + + + + +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE------KIQEWEEKIQEQEEKIREQE 327
Query: 1079 QKIIDAQEK 1087
+KI + +EK
Sbjct: 328 EKIREQEEK 336
Score = 31.2 bits (69), Expect = 5.9
Identities = 32/120 (26%), Positives = 60/120 (50%), Gaps = 14/120 (11%)
Query: 975 ETEQNLD----EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKA 1030
E EQ L + K A++Y +E+TK ++ L LE Y + +E + + L+ K
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDAL-----SLELYRNTITDEELKEKNAKLQEKL 230
Query: 1031 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEEL--KKDH--AEMQAVIDAKQKIIDAQE 1086
+L +S E+ Q K+ + K ++L+ +++L + DH E+Q+V Q ++ E
Sbjct: 231 QLVES-EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENE 289
Score = 30.4 bits (67), Expect = 10.0
Identities = 18/58 (31%), Positives = 36/58 (62%), Gaps = 3/58 (5%)
Query: 968 QYEEDVEETEQNL--DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQK 1023
+ EE ++E E+ + E K E+ E+++ + +E++R ++ E E RL QE++MQ+
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQ-EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 54.3 bits (129), Expect = 6e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1026
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 872 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1082
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 926 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 980
Query: 1083 DAQEKRIVSLDSANTRLMSALTQVKERYS 1111
E I+ +D N +L ++ER S
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Score = 39.3 bits (90), Expect = 0.022
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 921 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 973
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 974 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1026
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1086
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 1087 KRIVSLDSANTRLMSALTQVK 1107
+ + +L+ + L + K
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEK 1461
Score = 39.3 bits (90), Expect = 0.022
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 926 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 982
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1640 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 983 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1038
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1039 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1074
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1075 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1120
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Query: 1121 TNPTKLSITENGE 1133
K + E E
Sbjct: 1879 VKQLKRQLEEAEE 1891
Score = 37.0 bits (84), Expect = 0.11
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 966 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1024
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 1085 QEKRIVSLDSANTRLMSALTQVKE 1108
+ + DSA A+ Q+++
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRK 1649
Score = 36.2 bits (82), Expect = 0.18
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1030
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1019 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 1031 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1085
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1130
Score = 34.3 bits (77), Expect = 0.69
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1027
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1031 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 1028 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1139
Query: 1088 R 1088
+
Sbjct: 1140 Q 1140
Score = 32.7 bits (73), Expect = 2.0
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 971 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1029
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 1030 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1089
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1264
Query: 1090 VSLDSANTRLMSALTQVKERYSMQVRN 1116
S S R + L + +V +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVES 1291
Score = 32.0 bits (71), Expect = 3.4
Identities = 34/172 (19%), Positives = 67/172 (38%), Gaps = 40/172 (23%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1833
Query: 977 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRL 1014
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE--- 1890
Query: 1015 LVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1066
E R+ + +L+R+ +E +++ + A++ +L++
Sbjct: 1891 ------------EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1033
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1156
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1093
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1213
Score = 31.6 bits (70), Expect = 4.5
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 968 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1023
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1024 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1061
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1062 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1087
+E K K+ AE V K+++ +A+E+
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 30.4 bits (67), Expect = 10.0
Identities = 25/128 (19%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 965 NNGQYEEDVEETEQNLD-----EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL---LV 1016
N Q ++E+ ++ D E + KY E + + R + R L L
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 1017 QEQQMQKLLLEYKARLED---SEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQA 1073
++++++ KA +ED S++ + + E + +++ +++ ++ +L++ E+QA
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 1074 VIDAKQKI 1081
DAK ++
Sbjct: 1558 TEDAKLRL 1565
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 54.3 bits (129), Expect = 6e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1026
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 879 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1082
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 933 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 987
Query: 1083 DAQEKRIVSLDSANTRLMSALTQVKERYS 1111
E I+ +D N +L ++ER S
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Score = 39.3 bits (90), Expect = 0.022
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 921 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 973
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 974 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1026
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1086
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 1087 KRIVSLDSANTRLMSALTQVK 1107
+ + +L+ + L + K
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEK 1468
Score = 39.3 bits (90), Expect = 0.022
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 926 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 982
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1647 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 983 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1038
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1039 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1074
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1075 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1120
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Query: 1121 TNPTKLSITENGE 1133
K + E E
Sbjct: 1886 VKQLKRQLEEAEE 1898
Score = 37.0 bits (84), Expect = 0.11
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 966 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1024
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 1085 QEKRIVSLDSANTRLMSALTQVKE 1108
+ + DSA A+ Q+++
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRK 1656
Score = 36.2 bits (82), Expect = 0.18
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1030
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1026 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 1031 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1085
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1137
Score = 34.3 bits (77), Expect = 0.69
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1027
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1038 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 1028 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1146
Query: 1088 R 1088
+
Sbjct: 1147 Q 1147
Score = 32.7 bits (73), Expect = 2.0
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 971 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1029
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 1030 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1089
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1271
Query: 1090 VSLDSANTRLMSALTQVKERYSMQVRN 1116
S S R + L + +V +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVES 1298
Score = 32.0 bits (71), Expect = 3.4
Identities = 34/172 (19%), Positives = 67/172 (38%), Gaps = 40/172 (23%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1840
Query: 977 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYERRL 1014
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE--- 1897
Query: 1015 LVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKK 1066
E R+ + +L+R+ +E +++ + A++ +L++
Sbjct: 1898 ------------EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1033
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1163
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1093
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1220
Score = 31.6 bits (70), Expect = 4.5
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 968 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1023
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1024 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1061
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1062 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1087
+E K K+ AE V K+++ +A+E+
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 30.4 bits (67), Expect = 10.0
Identities = 25/128 (19%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 965 NNGQYEEDVEETEQNLD-----EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL---LV 1016
N Q ++E+ ++ D E + KY E + + R + R L L
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 1017 QEQQMQKLLLEYKARLED---SEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQA 1073
++++++ KA +ED S++ + + E + +++ +++ ++ +L++ E+QA
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 1074 VIDAKQKI 1081
DAK ++
Sbjct: 1565 TEDAKLRL 1572
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 54.3 bits (129), Expect = 6e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1026
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 879 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1082
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 933 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 987
Query: 1083 DAQEKRIVSLDSANTRLMSALTQVKERYS 1111
E I+ +D N +L ++ER S
Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERIS 1016
Score = 39.3 bits (90), Expect = 0.022
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 921 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 973
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 974 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1026
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1086
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 1087 KRIVSLDSANTRLMSALTQVK 1107
+ + +L+ + L + K
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEK 1468
Score = 39.3 bits (90), Expect = 0.022
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 926 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 982
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1647 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 983 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1038
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 1039 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1074
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825
Query: 1075 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1120
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885
Query: 1121 TNPTKLSITENGE 1133
K + E E
Sbjct: 1886 VKQLKRQLEEAEE 1898
Score = 37.0 bits (84), Expect = 0.11
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 966 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1024
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 1085 QEKRIVSLDSANTRLMSALTQVKE 1108
+ + DSA A+ Q+++
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRK 1656
Score = 36.2 bits (82), Expect = 0.18
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1030
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1026 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 1031 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1085
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1137
Score = 34.3 bits (77), Expect = 0.69
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1027
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1038 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 1028 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1146
Query: 1088 R 1088
+
Sbjct: 1147 Q 1147
Score = 32.7 bits (73), Expect = 2.0
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 971 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1029
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 1030 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1089
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1271
Query: 1090 VSLDSANTRLMSALTQVKERYSMQVRN 1116
S S R + L + +V +
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVES 1298
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1033
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1163
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1093
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1220
Score = 31.6 bits (70), Expect = 4.5
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 968 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1023
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 1024 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1061
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1062 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1087
+E K K+ AE V K+++ +A+E+
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 31.2 bits (69), Expect = 5.9
Identities = 35/160 (21%), Positives = 65/160 (40%), Gaps = 32/160 (20%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1840
Query: 977 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYE--- 1011
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 1012 RRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMK 1051
+R+ +++Q+ L E +S E + R+ S+++
Sbjct: 1901 QRINANRRKLQRELDE----ATESNEAMGREVNALKSKLR 1936
Score = 30.4 bits (67), Expect = 10.0
Identities = 25/128 (19%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 965 NNGQYEEDVEETEQNLD-----EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL---LV 1016
N Q ++E+ ++ D E + KY E + + R + R L L
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 1017 QEQQMQKLLLEYKARLED---SEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQA 1073
++++++ KA +ED S++ + + E + +++ +++ ++ +L++ E+QA
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 1074 VIDAKQKI 1081
DAK ++
Sbjct: 1565 TEDAKLRL 1572
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 54.3 bits (129), Expect = 6e-07
Identities = 42/149 (28%), Positives = 83/149 (55%), Gaps = 18/149 (12%)
Query: 970 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSR---RLEEYERRLLVQEQQMQKLLL 1026
E +++E EQ KH++ E++ L+E+L+ + EE RL ++Q+++++L
Sbjct: 872 ENELKELEQ-----KHSQLTEEK-NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAV----IDAKQKII 1082
E +ARLE+ E+R ++ Q E+ K + +++ +EE+L+++ A Q + + A+ K I
Sbjct: 926 EMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-I 980
Query: 1083 DAQEKRIVSLDSANTRLMSALTQVKERYS 1111
E I+ +D N +L ++ER S
Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Score = 39.3 bits (90), Expect = 0.022
Identities = 44/201 (21%), Positives = 90/201 (44%), Gaps = 15/201 (7%)
Query: 921 QSSSSRESPVPKVRAIQRQQTQQVQSPVDSAT--MSPVE----RTAAWVLNNGQYEEDV- 973
Q S+ S + RA + ++Q+ V+S T ++ E + A V + +D
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 974 ----EETEQNLDEAKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQKLLL 1026
EET Q L+ + + E+E L+++L + + LE + L +Q +K L
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 1027 EYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQE 1086
++ + +E EE +R Q+E ++ + + A ++L+K +Q +D +D Q
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEK-AAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 1087 KRIVSLDSANTRLMSALTQVK 1107
+ + +L+ + L + K
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEK 1461
Score = 39.3 bits (90), Expect = 0.022
Identities = 61/253 (24%), Positives = 106/253 (41%), Gaps = 46/253 (18%)
Query: 926 RESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQ---YEEDVEETEQNLDE 982
RE + ++R +Q Q + Q ++ A S E A N + E D+ + +++L
Sbjct: 1640 REEAIKQLRKLQAQM-KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 983 AKHAEKY-EQEITKLKERLRVS---SRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEER 1038
A+ A K + E +L E L S L++ +RRL + Q+++ L E + +E +R
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 1039 LRR--QQEEK----------------------DSQMKSIISRLMAVEEELKKDHAEMQAV 1074
+R+ QQ E+ + Q K + S+L +E +K A
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 1075 IDAK------QKIIDAQEKRIV--SLDSANTRLMSALTQVK------ERYSMQVRNGISP 1120
++AK Q +A+EK+ SL + +L L QV+ E+Y Q G +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878
Query: 1121 TNPTKLSITENGE 1133
K + E E
Sbjct: 1879 VKQLKRQLEEAEE 1891
Score = 37.0 bits (84), Expect = 0.11
Identities = 29/144 (20%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Query: 966 NGQYEEDVEETEQNLDEA-KHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL 1024
N + ++E+ + D+ K+ + E+ L+ ++ +LEE E L E +L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 1025 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA 1084
+ +A E L+ + E+ + + + + +L E EL+ + + AK+K+
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 1085 QEKRIVSLDSANTRLMSALTQVKE 1108
+ + DSA A+ Q+++
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRK 1649
Score = 36.2 bits (82), Expect = 0.18
Identities = 27/115 (23%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLR---VSSRRLEEYERRLLVQEQQMQKLLLEYKA 1030
EE +NL + K+ K+E I++L+ RL+ S + LE+ +R+L + + + +A
Sbjct: 1019 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 1031 RLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQ 1085
++ + + +L +++EE + + + + LKK E++ I Q+ +D++
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1130
Score = 34.3 bits (77), Expect = 0.69
Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 11/121 (9%)
Query: 968 QYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLE 1027
++E + E E L K EK QE+ KLK +L + E L Q +++ L +
Sbjct: 1031 KHESMISELEVRL---KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 1028 YKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEK 1087
+ L+ + RL + +K++ +K I EL+ +++Q +D+++ + EK
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKI--------RELEGHISDLQEDLDSERAARNKAEK 1139
Query: 1088 R 1088
+
Sbjct: 1140 Q 1140
Score = 32.7 bits (73), Expect = 2.0
Identities = 28/147 (19%), Positives = 67/147 (45%), Gaps = 2/147 (1%)
Query: 971 EDVEETEQNLDEAKHAEKYEQEI-TKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK 1029
E++E + L++ + +QE+ K ++ + V + L+E R Q Q+M++ +
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 1030 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI 1089
L + E+ +R + D +++ + EL+ + + ++ K+K ++AQ + +
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQEL 1264
Query: 1090 VSLDSANTRLMSALTQVKERYSMQVRN 1116
S S R + L + +V +
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVES 1291
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/120 (23%), Positives = 54/120 (45%), Gaps = 7/120 (5%)
Query: 974 EETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLE 1033
+E Q + K + E I+ L+E L + E+ Q++ + + L K LE
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK----QKRDLGEELEALKTELE 1156
Query: 1034 DSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLD 1093
D+ + QQE + + + + A++EE + A++Q + +QK A E+ L+
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ---EMRQKHAQAVEELTEQLE 1213
Score = 31.6 bits (70), Expect = 4.5
Identities = 35/153 (22%), Positives = 72/153 (47%), Gaps = 33/153 (21%)
Query: 968 QYEEDVEETEQNLDE-AKHAEKYEQEITKLKERL---RVSSRRLEEYERRLLVQEQQMQK 1023
Q EE++EE + N++ + K Q+ +L L R ++++ E ++L Q ++++
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 1024 LLLEYK---------------ARLEDSEERLRRQQEEKDSQMKSIISR-------LMAVE 1061
L E + A++ EE++ ++ EK + KS+ + L+ VE
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1062 EELK-----KDHAEM--QAVIDAKQKIIDAQEK 1087
+E K K+ AE V K+++ +A+E+
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 31.2 bits (69), Expect = 5.9
Identities = 35/160 (21%), Positives = 65/160 (40%), Gaps = 32/160 (20%)
Query: 917 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET 976
RS Q + S + + R + +++ V S S + A + Q EE VE+
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---AQLEEQVEQE 1833
Query: 977 EQNL----------------------DEAKHAEKYEQEITKLKERLRVSSRRLEEYE--- 1011
+ DE K AE+Y+++ K R++ R+LEE E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 1012 RRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMK 1051
+R+ +++Q+ L E +S E + R+ S+++
Sbjct: 1894 QRINANRRKLQRELDE----ATESNEAMGREVNALKSKLR 1929
Score = 30.4 bits (67), Expect = 10.0
Identities = 25/128 (19%), Positives = 60/128 (46%), Gaps = 11/128 (8%)
Query: 965 NNGQYEEDVEETEQNLD-----EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL---LV 1016
N Q ++E+ ++ D E + KY E + + R + R L L
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 1017 QEQQMQKLLLEYKARLED---SEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQA 1073
++++++ KA +ED S++ + + E + +++ +++ ++ +L++ E+QA
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 1074 VIDAKQKI 1081
DAK ++
Sbjct: 1558 TEDAKLRL 1565
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,592,934
Number of Sequences: 37866
Number of extensions: 1997797
Number of successful extensions: 13874
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 288
Number of HSP's successfully gapped in prelim test: 852
Number of HSP's that attempted gapping in prelim test: 8409
Number of HSP's gapped (non-prelim): 4143
length of query: 1139
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1026
effective length of database: 13,968,660
effective search space: 14331845160
effective search space used: 14331845160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.