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Search of human proteins with 4758504
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
(261 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 508 e-144
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 484 e-137
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 124 6e-29
gi|40254992 carbonic reductase 4 [Homo sapiens] 118 6e-27
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 110 2e-24
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 91 8e-19
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens] 87 2e-17
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 73 2e-13
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 71 8e-13
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 70 1e-12
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 70 1e-12
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 70 1e-12
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 70 2e-12
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 64 1e-10
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 64 1e-10
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 63 2e-10
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 62 4e-10
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 62 4e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 61 1e-09
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 60 2e-09
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 60 3e-09
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 59 3e-09
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 59 3e-09
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 59 3e-09
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 59 3e-09
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 58 7e-09
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 58 7e-09
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 56 3e-08
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 56 4e-08
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 54 1e-07
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 508 bits (1309), Expect = e-144
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 1 MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
Sbjct: 1 MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60
Query: 61 APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120
APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
Sbjct: 61 APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120
Query: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180
NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
Sbjct: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180
Query: 181 PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI 240
PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
Sbjct: 181 PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI 240
Query: 241 IENPFLNGEVIRLDGAIRMQP 261
IENPFLNGEVIRLDGAIRMQP
Sbjct: 241 IENPFLNGEVIRLDGAIRMQP 261
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 484 bits (1245), Expect = e-137
Identities = 252/261 (96%), Positives = 252/261 (96%), Gaps = 9/261 (3%)
Query: 1 MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
Sbjct: 1 MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF 60
Query: 61 APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120
APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
Sbjct: 61 APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV 120
Query: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180
NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
Sbjct: 121 NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL 180
Query: 181 PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI 240
PIARDLAPI GLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
Sbjct: 181 PIARDLAPI---------GLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI 231
Query: 241 IENPFLNGEVIRLDGAIRMQP 261
IENPFLNGEVIRLDGAIRMQP
Sbjct: 232 IENPFLNGEVIRLDGAIRMQP 252
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 124 bits (312), Expect = 6e-29
Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 27/266 (10%)
Query: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLG-----------N 56
++ +A++TG SG+G A + RL G+GA+ DL + + + LG N
Sbjct: 9 LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68
Query: 57 NCVFAPADVTSEKDVQTALALAKGKFGRV-DVAVNCAGIAVASKTYNLKKGQTHTLEDFQ 115
+ F ADV+ + + L + F R V V+CAGI ++ + +D+
Sbjct: 69 HAAFQ-ADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSE------DDWD 121
Query: 116 RVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGI 175
+V+ VNL GTF V + A + N G RG IIN +S+ G VGQ Y+ASK G+
Sbjct: 122 KVIAVNLKGTFLVTQAAAQALVSN-----GCRGSIINISSIVGKVGNVGQTNYAASKAGV 176
Query: 176 VGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAH 235
+G+T AR+L GIR ++ PG TP+ +P+KV + + +P LGDP + A
Sbjct: 177 IGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPM-GHLGDPEDVAD 235
Query: 236 LVQ--AIIENPFLNGEVIRLDGAIRM 259
+V A ++ ++ G + + G + M
Sbjct: 236 VVAFLASEDSGYITGTSVEVTGGLFM 261
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 118 bits (295), Expect = 6e-27
Identities = 79/248 (31%), Positives = 124/248 (50%), Gaps = 16/248 (6%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDV 71
V + GG+ G+G A A+ + +G ++ G +A A LG + + DV E DV
Sbjct: 4 VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDV 63
Query: 72 QTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRL 131
Q + GRV+ VN AGI ++ L + +T ED L NL+G+ +
Sbjct: 64 QNTFEELEKHLGRVNFLVNAAGI---NRDGLLVRTKT---EDMVSQLHTNLLGSMLTCKA 117
Query: 132 VAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGI 191
M Q Q G I+N S+ +G GQ+ YSASKGG+VG + +A+++A I
Sbjct: 118 AMRTMIQQ------QGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKI 171
Query: 192 RVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVI 251
RV +APG T + L E+ L +P R G+ E AH V ++E+P++ G V+
Sbjct: 172 RVNVVAPGFVHTDMTKDLKEE---HLKKNIPL-GRFGETIEVAHAVVFLLESPYITGHVL 227
Query: 252 RLDGAIRM 259
+DG +++
Sbjct: 228 VVDGGLQL 235
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 110 bits (274), Expect = 2e-24
Identities = 74/228 (32%), Positives = 114/228 (50%), Gaps = 18/228 (7%)
Query: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
G V V+TGG G+G V GA V+ D SGG A ++L VF DVT E
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPG-AVFILCDVTQED 67
Query: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
DV+T ++ +FGR+D VN AG + + + + + F+++L++NL+GT+ +
Sbjct: 68 DVKTLVSETIRRFGRLDCVVNNAGHHPPPQ-----RPEETSAQGFRQLLELNLLGTYTLT 122
Query: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPI 189
+L + +++ G +IN +S+ GQ Y A+KG + MT +A D +P
Sbjct: 123 KLALPYLRKSQ-------GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPY 175
Query: 190 GIRVMTIAPGLFGTPLLTSL----PEKVCNFLASQVPFP-SRLGDPAE 232
G+RV I+PG TPL L P+ + P R+G PAE
Sbjct: 176 GVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAE 223
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 91.3 bits (225), Expect = 8e-19
Identities = 74/262 (28%), Positives = 121/262 (46%), Gaps = 35/262 (13%)
Query: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
V G VA++TG A G+G A AE L+ +GA L+D G L +F
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
DV ++ ++ FGR+D+ VN AG+ + +++++ L +NL
Sbjct: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108
Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT--L 180
+ + L M + GG+ G+IIN +S+A Q Y ASK GIVG T
Sbjct: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSA 165
Query: 181 PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEY------- 233
+A +L G+R+ I PG T +L S+ EK N + + + + D +Y
Sbjct: 166 ALAANLMNSGVRLNAICPGFVNTAILESI-EKEEN-MGQYIEYKDHIKDMIKYYGILDPP 223
Query: 234 --AHLVQAIIENPFLNGEVIRL 253
A+ + +IE+ LNG ++++
Sbjct: 224 LIANGLITLIEDDALNGAIMKI 245
>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
Length = 292
Score = 86.7 bits (213), Expect = 2e-17
Identities = 77/253 (30%), Positives = 115/253 (45%), Gaps = 22/253 (8%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFAPADVTS 67
VA ITGG SG+G AE + G V+ A+KL G C+ DV +
Sbjct: 30 VAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRA 89
Query: 68 EKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
V A+ A +FGR+D+ +NCA L + F+ V+D++ GTFN
Sbjct: 90 PPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL------SFNAFKTVMDIDTSGTFN 143
Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
V R++ + + D GG VI+N + GQ Q ++K + MT +A +
Sbjct: 144 VSRVLYEKFFR---DHGG---VIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWG 197
Query: 188 PIGIRVMTIAPG-LFGTPLLTSL--PEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIE-- 242
P IRV ++APG + GT L L P+ + + P RLG+ E AH V +
Sbjct: 198 PQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPL-QRLGNKTEIAHSVLYLASPL 256
Query: 243 NPFLNGEVIRLDG 255
++ G V+ DG
Sbjct: 257 ASYVTGAVLVADG 269
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 73.2 bits (178), Expect = 2e-13
Identities = 53/177 (29%), Positives = 81/177 (45%), Gaps = 22/177 (12%)
Query: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
V G VA++TG A G+G A AE L+ +GA L+D G L +F
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
Query: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
DV ++ ++ FGR+D+ VN AG+ + +++++ L +NL
Sbjct: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108
Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
+ + L M + GG+ G+IIN +S+A Q Y ASK GIVG T
Sbjct: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFT 162
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 71.2 bits (173), Expect = 8e-13
Identities = 66/250 (26%), Positives = 111/250 (44%), Gaps = 17/250 (6%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
VA++T G+G A A RL GA V+ + L G + V
Sbjct: 34 VALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKA 93
Query: 69 KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128
+D + +A A G +D+ V+ A + + T E + + LD+N+ +
Sbjct: 94 EDRERLVATAVKLHGGIDILVSNAAVNPFFGSI-----MDVTEEVWDKTLDINVKAPALM 148
Query: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
+ V EM + +GG G ++ +S+AAF G + Y+ SK ++G+T +A +LAP
Sbjct: 149 TKAVVPEMEK----RGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202
Query: 189 IGIRVMTIAPGLFGTPLLTSL-PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII--ENPF 245
IRV +APGL T L +K + RLG+P + A +V + + +
Sbjct: 203 RNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASY 262
Query: 246 LNGEVIRLDG 255
+ GE + + G
Sbjct: 263 ITGETVVVGG 272
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 70.5 bits (171), Expect = 1e-12
Identities = 66/227 (29%), Positives = 98/227 (43%), Gaps = 27/227 (11%)
Query: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF--------- 60
G V ++TG +GLG A A +GA V+ DL GG+ + G+
Sbjct: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDL---GGDFKGVGKGSLAADKVVEEIRRR 65
Query: 61 ---APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
A A+ S ++ + + A FGR+DV VN AGI + ED+ +
Sbjct: 66 GGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISD------EDWDII 119
Query: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
V+L G+F V R M + + G II T+S + G GQA YSA+K G++G
Sbjct: 120 HRVHLRGSFQVTRAAWEHMKKQK------YGRIIMTSSASGIYGNFGQANYSAAKLGLLG 173
Query: 178 MTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFP 224
+ +A + I TIAP T +PE + L + P
Sbjct: 174 LANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAP 220
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 70.5 bits (171), Expect = 1e-12
Identities = 59/197 (29%), Positives = 88/197 (44%), Gaps = 19/197 (9%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
VAV+TG SG+G A A RL GA V+ + KL G + V
Sbjct: 38 VAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKA 97
Query: 69 KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED--FQRVLDVNLMGTF 126
+D + +A A G VD V AG+ N G T + + ++L VN
Sbjct: 98 EDREQLVAKALEHCGGVDFLVCSAGV-------NPLVGSTLGTSEQIWDKILSVN----- 145
Query: 127 NVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 186
++ A + Q P +RG +I +S+AA+ V Y+ SK ++G+T +A +L
Sbjct: 146 --VKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203
Query: 187 APIGIRVMTIAPGLFGT 203
AP IRV + PG+ T
Sbjct: 204 APKDIRVNCVVPGIIKT 220
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 70.5 bits (171), Expect = 1e-12
Identities = 59/197 (29%), Positives = 88/197 (44%), Gaps = 19/197 (9%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
VAV+TG SG+G A A RL GA V+ + KL G + V
Sbjct: 38 VAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKA 97
Query: 69 KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED--FQRVLDVNLMGTF 126
+D + +A A G VD V AG+ N G T + + ++L VN
Sbjct: 98 EDREQLVAKALEHCGGVDFLVCSAGV-------NPLVGSTLGTSEQIWDKILSVN----- 145
Query: 127 NVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 186
++ A + Q P +RG +I +S+AA+ V Y+ SK ++G+T +A +L
Sbjct: 146 --VKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203
Query: 187 APIGIRVMTIAPGLFGT 203
AP IRV + PG+ T
Sbjct: 204 APKDIRVNCVVPGIIKT 220
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 69.7 bits (169), Expect = 2e-12
Identities = 61/207 (29%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 7 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKK------LGNNCVF 60
++ G V+TGG+SG+G A QGA L+ N QAKK + + V
Sbjct: 29 ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLV-ARNEDKLLQAKKEIEMHSINDKQVV 87
Query: 61 APADVTSEKD---VQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
V +D V+ + A+ K G VD+ VNCAG+AV+ K +L+ + F+R+
Sbjct: 88 LCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLE------VSTFERL 141
Query: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
+ +N +G+ R V M + + G I+ +S A G G AYSASK I G
Sbjct: 142 MSINYLGSVYPSRAVITTMKER------RVGRIVFVSSQAGQLGLFGFTAYSASKFAIRG 195
Query: 178 MTLPIARDLAPIGIRVMTIAPGLFGTP 204
+ + ++ P + + P TP
Sbjct: 196 LAEALQMEVKPYNVYITVAYPPDTDTP 222
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 64.3 bits (155), Expect = 1e-10
Identities = 71/256 (27%), Positives = 109/256 (42%), Gaps = 26/256 (10%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
VA++T +G A A+RL GA V+ + L G + V
Sbjct: 34 VALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKM 93
Query: 69 KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQ-----THTLED-FQRVLDVNL 122
KD + +A A G +D+ ++ N K+G T E+ + R LD+N
Sbjct: 94 KDWERLVATAMKLHGVIDI--------LSLSITNSKRGLFWFTLLQTAEEAWDRNLDING 145
Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
+I+ V EM E GG G + ASVAAF G + Y+ SK ++G+ +
Sbjct: 146 KALALMIKAVVPEM---EKRGGGSVGFL---ASVAAFRPLPGFSPYNVSKTALLGLNKTL 199
Query: 183 ARDLAPIGIRVMTIAPGLFGTPLLTSL-PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 241
A +LAP IRV +APGL T L +K + RLG+P + +V +
Sbjct: 200 AIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLC 259
Query: 242 --ENPFLNGEVIRLDG 255
+ +L GE + + G
Sbjct: 260 SEDASYLTGETVMVGG 275
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 63.9 bits (154), Expect = 1e-10
Identities = 74/230 (32%), Positives = 98/230 (42%), Gaps = 35/230 (15%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A +L +G + L SG E + + D+T + VQ A
Sbjct: 33 ITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQA 92
Query: 75 LALAK------GKFGRVDVAVNCAGIA-VASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
+ G FG VN AG+A + T L T +DFQRVL+VN MG
Sbjct: 93 AKWVEMHVKEAGLFG----LVNNAGVAGIIGPTPWL------TRDDFQRVLNVNTMGPIG 142
Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
V + + Q RG +IN SV G Y SK G+ + + RD+A
Sbjct: 143 VTLALLPLLQQ-------ARGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDVA 194
Query: 188 PIGIRVMTIAPGLFGTPL--LTSLPEKVCNFLASQVPFPSRLGDPAEYAH 235
GIRV + PG F TP+ L SL EK +++P PA AH
Sbjct: 195 HFGIRVSIVEPGFFRTPVTNLESL-EKTLQACWARLP-------PATQAH 236
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 63.2 bits (152), Expect = 2e-10
Identities = 63/254 (24%), Positives = 106/254 (41%), Gaps = 26/254 (10%)
Query: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
G V ++T A G+G A A +GA + D+ S + K G DVT +K
Sbjct: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQT--RVLDVTKKK 63
Query: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
+ + R+DV N AG + ++ +D+ +++N+ + +I
Sbjct: 64 QIDQFA----NEVERLDVLFNVAGFVHHGTVLDCEE------KDWDFSMNLNVRSMYLMI 113
Query: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAA-FEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
+ +M + G IIN +SVA+ +G V + YS +K ++G+T +A D
Sbjct: 114 KAFLPKM------LAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ 167
Query: 189 IGIRVMTIAPGLFGTPLLTSL------PEKVCN-FLASQVPFPSRLGDPAEYAHLVQAII 241
GIR + PG TP L PE+ N FL Q + + A
Sbjct: 168 QGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASD 227
Query: 242 ENPFLNGEVIRLDG 255
E+ ++ G + +DG
Sbjct: 228 ESAYVTGNPVIIDG 241
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 62.4 bits (150), Expect = 4e-10
Identities = 59/227 (25%), Positives = 94/227 (41%), Gaps = 27/227 (11%)
Query: 6 RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGE---AQAKKLGNNCVFAP 62
+SV G + +ITG G+G TA + VL D+ G E A+ K LG
Sbjct: 32 KSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFV 91
Query: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
D ++ +D+ ++ K + G V + VN AG+ S + + Q ++ +VN+
Sbjct: 92 VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQ------IEKTFEVNV 145
Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
+ F + M +N G I+ AS A AY +SK VG +
Sbjct: 146 LAHFWTTKAFLPAMTKN------NHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTL 199
Query: 183 ARDLAPI---GIRVMTIAPGLFGTPLL----TSL-----PEKVCNFL 217
+LA + G++ + P T + TSL PE+V N L
Sbjct: 200 TDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRL 246
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 62.4 bits (150), Expect = 4e-10
Identities = 66/236 (27%), Positives = 100/236 (42%), Gaps = 26/236 (11%)
Query: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
G ++TG G+G T + L GA V + S +A L C
Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVDLG 62
Query: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
D + A A G G VD+ VN A +A+ + K E F R +VNL V
Sbjct: 63 DWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVIQVS 115
Query: 130 RLVA-GEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
++VA G + + P G I+N +S + + Y ++KG + +T +A +L P
Sbjct: 116 QIVARGLIARGVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169
Query: 189 IGIRVMTIAPGLFGTPL---LTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 241
IRV + P + T + S P K L +++P LG AE H+V AI+
Sbjct: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTML-NRIP----LGKFAEVEHVVNAIL 220
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 60.8 bits (146), Expect = 1e-09
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 15/188 (7%)
Query: 6 RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGE---AQAKKLGNNCVFAP 62
+SV G + +ITG G+G T + + VL D+ G E A+ +KLG
Sbjct: 32 KSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYV 91
Query: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
D ++ +++ +L K + G V + VN AG + + K E+ + +VN+
Sbjct: 92 VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKD------EEITKTFEVNI 145
Query: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
+G F + + + M + G I+ ASV EG Y +SK VG +
Sbjct: 146 LGHFWITKALLPSMMER------NHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGL 199
Query: 183 ARDLAPIG 190
+L +G
Sbjct: 200 TSELQALG 207
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 60.1 bits (144), Expect = 2e-09
Identities = 67/242 (27%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 1 MAAACRSVKGLVAVITGGASGLGLATAERLVGQGAS-----AVLLDLPNSGG--EAQAKK 53
MAAA R+V +I+G +SG+GL A +L A + DL A +
Sbjct: 1 MAAAPRTV-----LISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEA 55
Query: 54 LGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED 113
LG A DV S++ V L+ +G+ VDV VN AG+ + L +L
Sbjct: 56 LGQTLTVAQLDVCSDESVAQCLSCIQGE---VDVLVNNAGMGLVGPLEGL------SLAA 106
Query: 114 FQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKG 173
Q V D N G +++ V M + ++G I+ +SV +G + Y+ASK
Sbjct: 107 MQNVFDTNFFGAVRLVKAVLPGMKRR------RQGHIVVISSVMGLQGVIFNDVYAASKF 160
Query: 174 GIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEY 233
+ G +A L I + + PG P++T K L +QV G E
Sbjct: 161 ALEGFFESLAIQLLQFNIFISLVEPG----PVVTEFEGK----LLAQVSMAEFPGTDPET 212
Query: 234 AH 235
H
Sbjct: 213 LH 214
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 59.7 bits (143), Expect = 3e-09
Identities = 63/262 (24%), Positives = 116/262 (44%), Gaps = 28/262 (10%)
Query: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLD-----LPNSGGEAQAK---KLGNNCV 59
++G VA++TGGA+G+G A + L+ G++ V+ L ++ E QA +
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 60 FAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLD 119
++ +E++V + FG+++ VN G S ++ H VL+
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHA------VLE 129
Query: 120 VNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179
NL GTF + + V + + GG V I + A F V A++ G+ +T
Sbjct: 130 TNLTGTFYMCKAVYSSWMK---EHGGSI-VNIIVPTKAGFPLAVHS---GAARAGVYNLT 182
Query: 180 LPIARDLAPIGIRVMTIAPGLFGTPLLT----SLPEKVCNFLASQVPFPSRLGDPAEYAH 235
+A + A GIR+ +APG+ + S + ++P R+G P E +
Sbjct: 183 KSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIP-AKRIGVPEEVSS 241
Query: 236 LVQAIIE--NPFLNGEVIRLDG 255
+V ++ F+ G+ + +DG
Sbjct: 242 VVCFLLSPAASFITGQSVDVDG 263
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 3e-09
Identities = 58/198 (29%), Positives = 83/198 (41%), Gaps = 25/198 (12%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A +G + L SG A + DVT ++V+
Sbjct: 34 ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93
Query: 75 LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127
K + G + +N AG+ V + T L TLED++ ++VNL G T N
Sbjct: 94 AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147
Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
++ LV G+ +IN +SV VG Y+ SK + G + RD+
Sbjct: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195
Query: 188 PIGIRVMTIAPGLFGTPL 205
G+ V I PGLF T L
Sbjct: 196 AFGVHVSCIEPGLFKTNL 213
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 3e-09
Identities = 58/198 (29%), Positives = 83/198 (41%), Gaps = 25/198 (12%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A +G + L SG A + DVT ++V+
Sbjct: 34 ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93
Query: 75 LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127
K + G + +N AG+ V + T L TLED++ ++VNL G T N
Sbjct: 94 AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147
Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
++ LV G+ +IN +SV VG Y+ SK + G + RD+
Sbjct: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195
Query: 188 PIGIRVMTIAPGLFGTPL 205
G+ V I PGLF T L
Sbjct: 196 AFGVHVSCIEPGLFKTNL 213
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 3e-09
Identities = 58/198 (29%), Positives = 83/198 (41%), Gaps = 25/198 (12%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A +G + L SG A + DVT ++V+
Sbjct: 34 ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93
Query: 75 LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127
K + G + +N AG+ V + T L TLED++ ++VNL G T N
Sbjct: 94 AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147
Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
++ LV G+ +IN +SV VG Y+ SK + G + RD+
Sbjct: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195
Query: 188 PIGIRVMTIAPGLFGTPL 205
G+ V I PGLF T L
Sbjct: 196 AFGVHVSCIEPGLFKTNL 213
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 59.3 bits (142), Expect = 3e-09
Identities = 58/198 (29%), Positives = 83/198 (41%), Gaps = 25/198 (12%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A +G + L SG A + DVT ++V+
Sbjct: 34 ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRT 93
Query: 75 LALAKGKFGRVDV--AVNCAGI-AVASKTYNLKKGQTHTLEDFQRVLDVNLMG----TFN 127
K + G + +N AG+ V + T L TLED++ ++VNL G T N
Sbjct: 94 AQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL------TLEDYREPIEVNLFGLISVTLN 147
Query: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
++ LV G+ +IN +SV VG Y+ SK + G + RD+
Sbjct: 148 MLPLVKKAQGR-----------VINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMK 195
Query: 188 PIGIRVMTIAPGLFGTPL 205
G+ V I PGLF T L
Sbjct: 196 AFGVHVSCIEPGLFKTNL 213
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 58.2 bits (139), Expect = 7e-09
Identities = 51/194 (26%), Positives = 82/194 (42%), Gaps = 15/194 (7%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A++LV +G + G + + DVT + ++ A
Sbjct: 30 ITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSESIKAA 89
Query: 75 LALAKGKFGRVDV--AVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLV 132
+ K G + VN AG+ + S + T +DF +V++VNL+G V +
Sbjct: 90 AQWVRDKVGEQGLWALVNNAGVGLPSGP-----NEWLTKDDFVKVINVNLVGLIEVTLHM 144
Query: 133 AGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIR 192
P RG ++N +S +G Y SK G+ + I R+L G++
Sbjct: 145 L-------PMVKRARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRELYYFGVK 196
Query: 193 VMTIAPGLFGTPLL 206
V I PG + T +L
Sbjct: 197 VCIIEPGNYRTAIL 210
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 58.2 bits (139), Expect = 7e-09
Identities = 56/195 (28%), Positives = 81/195 (41%), Gaps = 23/195 (11%)
Query: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
ITG SG G A +L +G + L G E + + DVT + V A
Sbjct: 34 ITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTESVAAA 93
Query: 75 LALAK------GKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128
K G +G VN AGI++ + L T +DF +LDVNL+G +V
Sbjct: 94 AQWVKECVRDKGLWG----LVNNAGISLPTAPNELL-----TKQDFVTILDVNLLGVIDV 144
Query: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
+ P RG ++N +SV G Y SK G+ + + R+L+
Sbjct: 145 TLSLL-------PLVRRARGRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSY 196
Query: 189 IGIRVMTIAPGLFGT 203
G++V I PG F T
Sbjct: 197 FGVKVAMIEPGYFKT 211
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 56.2 bits (134), Expect = 3e-08
Identities = 70/259 (27%), Positives = 105/259 (40%), Gaps = 23/259 (8%)
Query: 7 SVKGLVAVITGGASGLGLATAERLVGQGASAVL----LDLPNSGGEAQAKKLGNNCVFAP 62
S +G VA ITGG +GLG L GA V+ +D+ + E + + GN
Sbjct: 56 SFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
Query: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
DV VQ ++ G ++ +N A S T L T + D+ L
Sbjct: 116 CDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKT------ITDIVL 169
Query: 123 MGTFNVIRLVAGEMG-QNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLP 181
GT V E+G Q Q G + I T G V +A ++K G+ M+
Sbjct: 170 NGT----AFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSA--SAKAGVEAMSKS 223
Query: 182 IARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNF---LASQVPFPSRLGDPAEYAHLVQ 238
+A + G+R I PG T S + F + ++P RLG E A+L
Sbjct: 224 LAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPC-GRLGTVEELANLAA 282
Query: 239 AIIEN--PFLNGEVIRLDG 255
+ + ++NG VI+ DG
Sbjct: 283 FLCSDYASWINGAVIKFDG 301
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 55.8 bits (133), Expect = 4e-08
Identities = 55/217 (25%), Positives = 93/217 (42%), Gaps = 32/217 (14%)
Query: 7 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAK-----KLGNNCVFA 61
++ G ++TG +G+G TA L +G + +L EA AK L ++
Sbjct: 35 TIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNAR 94
Query: 62 PADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVN 121
D+ S K ++ A + RVD+ +N AG+ ++ T + F+ VN
Sbjct: 95 HLDLASLKSIREFAAKIIEEEERVDILINNAGV--------MRCPHWTTEDGFEMQFGVN 146
Query: 122 LMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVG-------------QAAY 168
+G F + L+ ++ + P + IIN +S+A G + +AAY
Sbjct: 147 HLGHFLLTNLLLDKLKASAPSR------IINLSSLAHVAGHIDFDDLNWQTRKYNTKAAY 200
Query: 169 SASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPL 205
SK IV T ++R L G+ V + PG+ T L
Sbjct: 201 CQSKLAIVLFTKELSRRLQGSGVTVNALHPGVARTEL 237
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 53.9 bits (128), Expect = 1e-07
Identities = 48/185 (25%), Positives = 82/185 (44%), Gaps = 14/185 (7%)
Query: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68
VA++T G+G A A RL A V+ + L G + V
Sbjct: 34 VALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKA 93
Query: 69 KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNV 128
+D + +A+A G +D+ V+ A + + T E + + LD+N+ +
Sbjct: 94 EDRERLVAMAVKLHGGIDILVSNAAVNPFFGSL-----MDVTEEVWDKTLDINVKAPALM 148
Query: 129 IRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
+ V EM + +GG G ++ +S+AAF G + Y+ SK ++G+ +A +LAP
Sbjct: 149 TKAVVPEMEK----RGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202
Query: 189 IGIRV 193
IRV
Sbjct: 203 RNIRV 207
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,135,073
Number of Sequences: 37866
Number of extensions: 400124
Number of successful extensions: 905
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 795
Number of HSP's gapped (non-prelim): 77
length of query: 261
length of database: 18,247,518
effective HSP length: 100
effective length of query: 161
effective length of database: 14,460,918
effective search space: 2328207798
effective search space used: 2328207798
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.