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Search of human proteins with 4758304
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
(645 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 1300 0.0
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 345 6e-95
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s... 260 2e-69
gi|94966757 protein disulfide isomerase A2 [Homo sapiens] 220 4e-57
gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 161 2e-39
gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ... 144 2e-34
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap... 144 2e-34
gi|5803121 protein disulfide isomerase A5 [Homo sapiens] 138 2e-32
gi|28372543 protein disulfide isomerase-like, testis expressed [... 133 4e-31
gi|38505222 thioredoxin domain containing 10 [Homo sapiens] 103 4e-22
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul... 103 4e-22
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s... 94 4e-19
gi|151101292 thioredoxin domain containing 1 [Homo sapiens] 65 2e-10
gi|119395727 cardiac calsequestrin 2 precursor [Homo sapiens] 62 2e-09
gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 62 2e-09
gi|21361403 thioredoxin 2 precursor [Homo sapiens] 60 5e-09
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap... 58 3e-08
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap... 58 3e-08
gi|227430327 calsequestrin 1 [Homo sapiens] 54 4e-07
gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa... 52 2e-06
gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa... 52 2e-06
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens] 49 1e-05
gi|50592994 thioredoxin [Homo sapiens] 48 2e-05
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 47 4e-05
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 47 4e-05
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 47 4e-05
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa... 46 1e-04
gi|94421469 disulfide isomerase [Homo sapiens] 45 2e-04
gi|95113651 glutaredoxin 3 [Homo sapiens] 44 5e-04
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 43 8e-04
>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
Length = 645
Score = 1300 bits (3365), Expect = 0.0
Identities = 645/645 (100%), Positives = 645/645 (100%)
Query: 1 MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKE 60
MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKE
Sbjct: 1 MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKE 60
Query: 61 ENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI 120
ENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI
Sbjct: 61 ENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI 120
Query: 121 DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL 180
DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL
Sbjct: 121 DATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL 180
Query: 181 VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE 240
VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE
Sbjct: 181 VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE 240
Query: 241 TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL 300
TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL
Sbjct: 241 TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFL 300
Query: 301 KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQP 360
KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQP
Sbjct: 301 KDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQP 360
Query: 361 EKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS 420
EKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS
Sbjct: 361 EKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYS 420
Query: 421 VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD 480
VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD
Sbjct: 421 VDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILD 480
Query: 481 ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVM 540
ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVM
Sbjct: 481 ESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVM 540
Query: 541 DPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF 600
DPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF
Sbjct: 541 DPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGF 600
Query: 601 PTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
PTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL
Sbjct: 601 PTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
Length = 505
Score = 345 bits (886), Expect = 6e-95
Identities = 200/477 (41%), Positives = 287/477 (60%), Gaps = 23/477 (4%)
Query: 180 LVLTKENFDEVVND---ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVD 236
L LT +NF+ ++D A ++LVEF+APWCGHCK+LAPEYE AA L +PLAKVD
Sbjct: 28 LELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI---VPLAKVD 84
Query: 237 ATAETDLAKRFDVSGYPTLKIFRKGRPYD-YNGPREKYGIVDYMIEQSGPPSKEILTLKQ 295
TA T+ ++ VSGYPTLKIFR G Y+GPR GIV ++ +Q+GP S + T ++
Sbjct: 85 CTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEE 144
Query: 296 VQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQL 355
++F+ D D I+G F A+ ++ AA+NLR++Y+F HT + + +
Sbjct: 145 FKKFISD-KDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGI 203
Query: 356 VVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTR-RPL 414
++ +P +K+E ++ Q T IK F+ + + H ++ D K + + L
Sbjct: 204 ILFRPSHLTNKFEDKTVAYTEQKMTSGK-IKKFIQENIFGICPH--MTEDNKDLIQGKDL 260
Query: 415 VVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPE----YTFAIADEEDYAGEVKDLGL-SE 469
++ YY VD+ + + + +WR++V+ VAK F + FA+A + ++ E+ D GL S
Sbjct: 261 LIAYYDVDYEKNAKGSN-YWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLEST 319
Query: 470 SGEDVNAAILDESGKKFAMEPEEFDSD--TLREFVTAFKKGKLKPVIKSQPVPKNNKGPV 527
+GE AI G+KF M+ EEF D L F+ + G LK +KS+P+P++N GPV
Sbjct: 320 AGEIPVVAIRTAKGEKFVMQ-EEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPV 378
Query: 528 KVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATA 587
KVVV + FD IV + KDVLIEFYAPWCGHCK LEP Y L +K +VIAKMDATA
Sbjct: 379 KVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATA 438
Query: 588 NDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEE 644
NDVPS Y+V GFPTIYF+P+ K NP K+EGG R+L +++ AT +EE
Sbjct: 439 NDVPSP-YEVRGFPTIYFSPANKKLNPKKYEGG-RELSDFISYLQREATNPPVIQEE 493
Score = 103 bits (258), Expect = 4e-22
Identities = 56/143 (39%), Positives = 90/143 (62%), Gaps = 13/143 (9%)
Query: 64 VLVLNDANFDNFVADKDT---VLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI 120
VL L D NF++ ++D + +L+EF+APWCGHCK+ APEYE A LK +P+AK+
Sbjct: 27 VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG---IVPLAKV 83
Query: 121 DATSASVLASRFDVSGYPTIKILKKG-QAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVT 179
D T+ + +++ VSGYPT+KI + G +A Y+G RT + IV+ +++ + P P
Sbjct: 84 DCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVP----- 138
Query: 180 LVLTKENFDEVVNDADIILVEFY 202
+ T+E F + ++D D +V F+
Sbjct: 139 -LRTEEEFKKFISDKDASIVGFF 160
Score = 78.6 bits (192), Expect = 2e-14
Identities = 47/124 (37%), Positives = 72/124 (58%), Gaps = 7/124 (5%)
Query: 52 EEDDLEVKEENGVLVLNDANFDNFVADKDT-VLLEFYAPWCGHCKQFAPEYEKIANILKD 110
+ + + + V V+ NFD V +++ VL+EFYAPWCGHCK P+Y+++ L
Sbjct: 366 KSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKL-S 424
Query: 111 KDPPIPVAKIDATSASVLASRFDVSGYPTIKIL---KKGQAVDYEGSRTQEEIVAKV-RE 166
KDP I +AK+DAT A+ + S ++V G+PTI KK YEG R + ++ + RE
Sbjct: 425 KDPNIVIAKMDAT-ANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483
Query: 167 VSQP 170
+ P
Sbjct: 484 ATNP 487
>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
sapiens]
Length = 508
Score = 260 bits (665), Expect = 2e-69
Identities = 167/467 (35%), Positives = 252/467 (53%), Gaps = 36/467 (7%)
Query: 180 LVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATA 239
LVL K NF E + +LVEFYAPWCGHCK LAPEY KAA +L I LAKVDAT
Sbjct: 27 LVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATE 86
Query: 240 ETDLAKRFDVSGYPTLKIFRKG---RPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQV 296
E+DLA+++ V GYPT+K FR G P +Y RE IV+++ +++G P+ L
Sbjct: 87 ESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTG-PAATTLPDGAA 145
Query: 297 QEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLV 356
E L + +V +IG FK + +Q+ AA + +D F T ++++ ++ + +V
Sbjct: 146 AESLVESSEVAVIGFFKDVESDSAKQFLQAAEAI-DDIPFGITSNSDVFSKYQLDKDGVV 204
Query: 357 VMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRR---- 412
+ F+ E R++ +G + DF+ LPLV K +
Sbjct: 205 L-----FKKFDEGRNNF---EGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTH 256
Query: 413 -----PLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGL 467
P V Y S +++ A + ++ K+L + F +D D ++ GL
Sbjct: 257 ILLFLPKSVSDYDGKLS-NFKTAAESFKGKIL--------FIFIDSDHTDNQRILEFFGL 307
Query: 468 -SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKN-NKG 525
E V L+E K+ E EE ++ + EF F +GK+KP + SQ +P++ +K
Sbjct: 308 KKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQ 367
Query: 526 PVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDA 585
PVKV+VGK F+ + D KK+V +EFYAPWCGHCKQL P+++ L + YK + +VIAKMD+
Sbjct: 368 PVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDS 427
Query: 586 TANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIE 632
TAN+V + KV FPT+ F P+ + + + G+R L+ KF+E
Sbjct: 428 TANEV--EAVKVHSFPTLKFFPASADRTVIDY-NGERTLDGFKKFLE 471
Score = 111 bits (277), Expect = 2e-24
Identities = 95/360 (26%), Positives = 165/360 (45%), Gaps = 42/360 (11%)
Query: 59 KEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVA 118
+EE+ VLVL +NF +A +L+EFYAPWCGHCK APEY K A LK + I +A
Sbjct: 21 EEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLA 80
Query: 119 KIDATSASVLASRFDVSGYPTIKILKKGQAV---DYEGSRTQEEIVAKVREVSQPDWTPP 175
K+DAT S LA ++ V GYPTIK + G +Y R ++IV +++ + P T
Sbjct: 81 KVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTL 140
Query: 176 PEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235
P+ + +V +++ ++ F+ K + + K + ++ IP
Sbjct: 141 PDGAAA------ESLVESSEVAVIGFF-------KDVESDSAKQFLQAAEAIDDIPFG-- 185
Query: 236 DATAETDLAKRF--DVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTL 293
T+ +D+ ++ D G K F +GR ++ G K ++D++ P E
Sbjct: 186 -ITSNSDVFSKYQLDKDGVVLFKKFDEGR-NNFEGEVTKENLLDFIKHNQLPLVIEFTEQ 243
Query: 294 KQVQEFLKDGDDVIIIGVFKGES--DPAYQQYQDAANNLREDYKF-----HHTFSTEIAK 346
+ F + I++ + K S D ++ AA + + F HT + I +
Sbjct: 244 TAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILE 303
Query: 347 FLKVSQGQ-----LVVMQPEKFQSKYEPRSHMMDVQGSTQ------DSAIKDFVLKYALP 395
F + + + L+ ++ E +KY+P S + + T+ + IK ++ LP
Sbjct: 304 FFGLKKEECPAVRLITLEEE--MTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELP 361
Score = 72.4 bits (176), Expect = 1e-12
Identities = 41/101 (40%), Positives = 58/101 (57%), Gaps = 7/101 (6%)
Query: 60 EENGVLVLNDANFDNFVAD-KDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVA 118
++ V VL NF++ D K V +EFYAPWCGHCKQ AP ++K+ KD + I +A
Sbjct: 365 DKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHE-NIVIA 423
Query: 119 KIDATSASVLASRFDVSGYPTIKILKKG---QAVDYEGSRT 156
K+D+T+ V A + V +PT+K +DY G RT
Sbjct: 424 KMDSTANEVEAVK--VHSFPTLKFFPASADRTVIDYNGERT 462
Score = 70.9 bits (172), Expect = 4e-12
Identities = 47/114 (41%), Positives = 61/114 (53%), Gaps = 11/114 (9%)
Query: 171 DWTPPPEVTLVLTKENFDEVVNDADI-ILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPP 229
DW P VL +NF++V D + VEFYAPWCGHCK+LAP ++K E K
Sbjct: 363 DWDKQP--VKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLG-ETYKDHEN 419
Query: 230 IPLAKVDATA-ETDLAKRFDVSGYPTLKIFRKGRP---YDYNGPREKYGIVDYM 279
I +AK+D+TA E + K V +PTLK F DYNG R G ++
Sbjct: 420 IVIAKMDSTANEVEAVK---VHSFPTLKFFPASADRTVIDYNGERTLDGFKKFL 470
Score = 32.0 bits (71), Expect = 1.8
Identities = 14/37 (37%), Positives = 23/37 (62%)
Query: 25 EGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEE 61
E +D + ++ +ED EE EE D +E++D VK+E
Sbjct: 471 ESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDE 507
>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
Length = 525
Score = 220 bits (560), Expect = 4e-57
Identities = 150/490 (30%), Positives = 251/490 (51%), Gaps = 33/490 (6%)
Query: 157 QEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEY 216
QE+ E + P + LVL++ + + +LVEFYAPWCGHC+ LAPEY
Sbjct: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEY 81
Query: 217 EKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKG---RPYDYNGPREKY 273
KAA L+ S + LAKVD A+ +LA+ F V+ YPTLK FR G P +Y GPR+
Sbjct: 82 SKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAE 141
Query: 274 GIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLRED 333
GI +++ + GP + L + + L G D+++IG F+ D + A + D
Sbjct: 142 GIAEWLRRRVGPSAMR-LEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDAL-D 199
Query: 334 YKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHM-MDVQGSTQDSAIKDFVLKY 392
F T + + +++ +V+ F+ E R+ +D + + F++ +
Sbjct: 200 MTFGLTDRPRLFQQFGLTKDTVVL-----FKKFDEGRADFPVDEELGLDLGDLSRFLVTH 254
Query: 393 ALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSF--------DYRAATQFWRSKVLEVAKD 444
++ LV AK + R L + V+ + + A +R +VL V D
Sbjct: 255 SMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVD 314
Query: 445 FPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFA-MEPEEFDSDTLREFVT 503
AD E ++ GL + E+ KK+A ++ + ++ F
Sbjct: 315 ------VAADNEHV---LQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCH 365
Query: 504 AFKKGKLKPVIKSQPVPKN-NKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLE 562
A G++KP + SQ +P + ++ PVK +VGK F+ + D K+V ++FYAPWC HCK++
Sbjct: 366 AVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMA 425
Query: 563 PVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDR 622
P + +LA+KY+ + ++IA++DATAN++ D + V GFPT+ + P+G + ++++ R
Sbjct: 426 PAWEALAEKYQDHEDIIIAELDATANEL--DAFAVHGFPTLKYFPAGPGRKVIEYK-STR 482
Query: 623 DLEHLSKFIE 632
DLE SKF++
Sbjct: 483 DLETFSKFLD 492
Score = 90.5 bits (223), Expect = 4e-18
Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 3/127 (2%)
Query: 42 EEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEY 101
+E+ EE + E+ +E+G+LVL+ + + +L+EFYAPWCGHC+ APEY
Sbjct: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEY 81
Query: 102 EKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAV---DYEGSRTQE 158
K A +L + + +AK+D + LA F V+ YPT+K + G +Y G R E
Sbjct: 82 SKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAE 141
Query: 159 EIVAKVR 165
I +R
Sbjct: 142 GIAEWLR 148
Score = 63.2 bits (152), Expect = 7e-10
Identities = 36/103 (34%), Positives = 59/103 (57%), Gaps = 7/103 (6%)
Query: 60 EENGVLVLNDANFDNFVADKD-TVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVA 118
++ V L NF+ D+ V ++FYAPWC HCK+ AP +E +A +D + I +A
Sbjct: 386 DQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHE-DIIIA 444
Query: 119 KIDATSASVLASRFDVSGYPTIKILKKG---QAVDYEGSRTQE 158
++DAT+ + A F V G+PT+K G + ++Y+ +R E
Sbjct: 445 ELDATANELDA--FAVHGFPTLKYFPAGPGRKVIEYKSTRDLE 485
>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
Length = 440
Score = 161 bits (408), Expect = 2e-39
Identities = 99/259 (38%), Positives = 147/259 (56%), Gaps = 33/259 (12%)
Query: 64 VLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDA 122
V+ L +NF+ V D++ L+EFYAPWCGHC++ PE++K A LKD + V +DA
Sbjct: 27 VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDV---VKVGAVDA 83
Query: 123 TSASVLASRFDVSGYPTIKIL--KKGQAVDYEGSRTQEEIV----AKVREV--------- 167
L ++ V G+PTIKI K + DY+G RT E IV + +R++
Sbjct: 84 DKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRS 143
Query: 168 --------SQPDWTPPPEVTLVLTKENFDEVVNDA-DIILVEFYAPWCGHCKKLAPEYEK 218
+ D + +V + LT ++FD+ V D+ D+ +VEFYAPWCGHCK L PE+
Sbjct: 144 GGYSSGKQGRSDSSSKKDV-IELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAA 202
Query: 219 AAKELSKRSP-PIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGR-PYDYNGPREKYGIV 276
AA E+ +++ + LA VDAT LA R+ + G+PT+KIF+KG P DY+G R + IV
Sbjct: 203 AASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIV 262
Query: 277 DYMIE--QSGPPSKEILTL 293
++ P E+L +
Sbjct: 263 SRALDLFSDNAPPPELLEI 281
Score = 105 bits (261), Expect = 2e-22
Identities = 53/125 (42%), Positives = 84/125 (67%), Gaps = 4/125 (3%)
Query: 64 VLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDP-PIPVAKID 121
V+ L D +FD V D + V ++EFYAPWCGHCK PE+ A+ +K++ + +A +D
Sbjct: 162 VIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVD 221
Query: 122 ATSASVLASRFDVSGYPTIKILKKGQA-VDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL 180
AT VLASR+ + G+PTIKI +KG++ VDY+G RT+ +IV++ ++ D PPPE+
Sbjct: 222 ATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFS-DNAPPPELLE 280
Query: 181 VLTKE 185
++ ++
Sbjct: 281 IINED 285
Score = 82.8 bits (203), Expect = 9e-16
Identities = 45/113 (39%), Positives = 69/113 (61%), Gaps = 4/113 (3%)
Query: 522 NNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ-KGLV- 579
++K V + +FD V+D + ++EFYAPWCGHCK LEP + + A + K Q KG V
Sbjct: 157 SSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVK 216
Query: 580 IAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIE 632
+A +DAT N V + RY + GFPTI G+ +PV ++GG + +S+ ++
Sbjct: 217 LAAVDATVNQVLASRYGIRGFPTIKIFQKGE--SPVDYDGGRTRSDIVSRALD 267
Score = 57.4 bits (137), Expect = 4e-08
Identities = 29/74 (39%), Positives = 42/74 (56%), Gaps = 3/74 (4%)
Query: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFA 606
L+EFYAPWCGHC++L P + A K + + +DA + +Y V+GFPTI
Sbjct: 47 LVEFYAPWCGHCQRLTPEWKKAATALKDV--VKVGAVDADKHHSLGGQYGVQGFPTIKIF 104
Query: 607 PSGDKKNPVKFEGG 620
S +K P ++GG
Sbjct: 105 GS-NKNRPEDYQGG 117
>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
[Homo sapiens]
Length = 432
Score = 144 bits (364), Expect = 2e-34
Identities = 89/280 (31%), Positives = 145/280 (51%), Gaps = 24/280 (8%)
Query: 25 EGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLL 84
+GP + + ++ EE + E E + + G+ L+ +NF+ VA D +
Sbjct: 152 QGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FI 210
Query: 85 EFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144
+F+APWCGHCK AP +E++A L+ + + + K+D T L S V GYPT+ +
Sbjct: 211 KFFAPWCGHCKALAPTWEQLALGLEHSET-VKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269
Query: 145 KGQAVD-YEGSRTQEEIVAKVREVSQ---------------PDWTPPPEV----TLVLTK 184
G+ VD Y+G R E + V Q P PE L LT+
Sbjct: 270 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTE 329
Query: 185 ENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA 244
NFD+ + + I ++FYAPWCGHCK LAP +E+ +K+ + +A+VD TAE ++
Sbjct: 330 NNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 388
Query: 245 KRFDVSGYPTLKIFRKGRPY-DYNGPREKYGIVDYMIEQS 283
++ V GYPTL +FR G+ +++G R+ + +++ Q+
Sbjct: 389 SKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQA 428
Score = 126 bits (316), Expect = 7e-29
Identities = 78/212 (36%), Positives = 109/212 (51%), Gaps = 17/212 (8%)
Query: 86 FYAPWCGHCKQFAPEYEKIANILKD-KDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144
F+APWCGHC++ P + + + +D + VAK+D T+ S + S V GYPT+K+ K
Sbjct: 84 FFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFK 143
Query: 145 KGQ-AVDYEGSR------------TQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVV 191
GQ AV Y+G R EE V EV P + L+ NF+ V
Sbjct: 144 PGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHV 203
Query: 192 NDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSG 251
D ++F+APWCGHCK LAP +E+ A L + S + + KVD T +L V G
Sbjct: 204 AQGD-HFIKFFAPWCGHCKALAPTWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRG 261
Query: 252 YPTLKIFRKGRPYD-YNGPREKYGIVDYMIEQ 282
YPTL FR G+ D Y G R+ + +Y+ Q
Sbjct: 262 YPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293
Score = 87.8 bits (216), Expect = 3e-17
Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 21/173 (12%)
Query: 483 GKKFAMEPEEFDSDTLREFVTA----FKKGKLKPVIKSQ-PV----PKNNKGPVKVVVGK 533
GKK + D ++LRE+V + + G + V S+ PV P+ +KG V +
Sbjct: 271 GKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTEN 330
Query: 534 TFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKK-YKGQKGLVIAKMDATANDVPS 592
FD + + I+FYAPWCGHCK L P + L+KK + G G+ IA++D TA
Sbjct: 331 NFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 388
Query: 593 DRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
+Y V G+PT+ G K V G RDL+ L +F+ LS+ K+EL
Sbjct: 389 SKYSVRGYPTLLLFRGGKK---VSEHSGGRDLDSLHRFV------LSQAKDEL 432
Score = 69.7 bits (169), Expect = 8e-12
Identities = 34/85 (40%), Positives = 51/85 (60%), Gaps = 2/85 (2%)
Query: 199 VEFYAPWCGHCKKLAPEYEKAA-KELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKI 257
V F+APWCGHC++L P + K S + +AKVD TA +D+ V GYPTLK+
Sbjct: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
Query: 258 FRKGR-PYDYNGPREKYGIVDYMIE 281
F+ G+ Y GPR+ + ++M++
Sbjct: 142 FKPGQEAVKYQGPRDFQTLENWMLQ 166
Score = 65.9 bits (159), Expect = 1e-10
Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604
D I+F+APWCGHCK L P + LA + + + I K+D T + +V G+PT+
Sbjct: 207 DHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLL 266
Query: 605 FAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTK 642
+ G K + K G RDLE L +++E ++L RT+
Sbjct: 267 WFRDGKKVDQYK---GKRDLESLREYVE---SQLQRTE 298
Score = 60.8 bits (146), Expect = 4e-09
Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 5/86 (5%)
Query: 548 IEFYAPWCGHCKQLEPVYNSLAKKYKGQKG--LVIAKMDATANDVPSDRYKVEGFPTIYF 605
+ F+APWCGHC++L+P +N L KY + + +AK+D TA+ V G+PT+
Sbjct: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
Query: 606 APSGDKKNPVKFEGGDRDLEHLSKFI 631
G + VK++ G RD + L ++
Sbjct: 142 FKPG--QEAVKYQ-GPRDFQTLENWM 164
>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
sapiens]
Length = 324
Score = 144 bits (364), Expect = 2e-34
Identities = 89/280 (31%), Positives = 145/280 (51%), Gaps = 24/280 (8%)
Query: 25 EGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLL 84
+GP + + ++ EE + E E + + G+ L+ +NF+ VA D +
Sbjct: 44 QGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FI 102
Query: 85 EFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144
+F+APWCGHCK AP +E++A L+ + + + K+D T L S V GYPT+ +
Sbjct: 103 KFFAPWCGHCKALAPTWEQLALGLEHSET-VKIGKVDCTQHYELCSGNQVRGYPTLLWFR 161
Query: 145 KGQAVD-YEGSRTQEEIVAKVREVSQ---------------PDWTPPPEV----TLVLTK 184
G+ VD Y+G R E + V Q P PE L LT+
Sbjct: 162 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTE 221
Query: 185 ENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA 244
NFD+ + + I ++FYAPWCGHCK LAP +E+ +K+ + +A+VD TAE ++
Sbjct: 222 NNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 280
Query: 245 KRFDVSGYPTLKIFRKGRPY-DYNGPREKYGIVDYMIEQS 283
++ V GYPTL +FR G+ +++G R+ + +++ Q+
Sbjct: 281 SKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQA 320
Score = 103 bits (258), Expect = 4e-22
Identities = 69/186 (37%), Positives = 94/186 (50%), Gaps = 16/186 (8%)
Query: 111 KDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQ-AVDYEGSR------------TQ 157
+D + VAK+D T+ S + S V GYPT+K+ K GQ AV Y+G R
Sbjct: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLN 61
Query: 158 EEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYE 217
EE V EV P + L+ NF+ V D ++F+APWCGHCK LAP +E
Sbjct: 62 EEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGD-HFIKFFAPWCGHCKALAPTWE 120
Query: 218 KAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYD-YNGPREKYGIV 276
+ A L + S + + KVD T +L V GYPTL FR G+ D Y G R+ +
Sbjct: 121 QLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLR 179
Query: 277 DYMIEQ 282
+Y+ Q
Sbjct: 180 EYVESQ 185
Score = 87.8 bits (216), Expect = 3e-17
Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 21/173 (12%)
Query: 483 GKKFAMEPEEFDSDTLREFVTA----FKKGKLKPVIKSQ-PV----PKNNKGPVKVVVGK 533
GKK + D ++LRE+V + + G + V S+ PV P+ +KG V +
Sbjct: 163 GKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTEN 222
Query: 534 TFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKK-YKGQKGLVIAKMDATANDVPS 592
FD + + I+FYAPWCGHCK L P + L+KK + G G+ IA++D TA
Sbjct: 223 NFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 280
Query: 593 DRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
+Y V G+PT+ G K V G RDL+ L +F+ LS+ K+EL
Sbjct: 281 SKYSVRGYPTLLLFRGGKK---VSEHSGGRDLDSLHRFV------LSQAKDEL 324
Score = 65.9 bits (159), Expect = 1e-10
Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604
D I+F+APWCGHCK L P + LA + + + I K+D T + +V G+PT+
Sbjct: 99 DHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLL 158
Query: 605 FAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTK 642
+ G K + K G RDLE L +++E ++L RT+
Sbjct: 159 WFRDGKKVDQYK---GKRDLESLREYVE---SQLQRTE 190
>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
Length = 519
Score = 138 bits (347), Expect = 2e-32
Identities = 84/232 (36%), Positives = 118/232 (50%), Gaps = 16/232 (6%)
Query: 60 EENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILK-DKDPPIPVA 118
E V L D +FD FV + +VL+ F+APWCGHCK+ PE+EK A L + D +A
Sbjct: 274 EGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLA 333
Query: 119 KIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEV 178
+DAT LA RF +S +PT+K K G+ RT+++ + + P+ PPPE
Sbjct: 334 AVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKF---LEWMQNPEAPPPPEP 390
Query: 179 T--------LVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPI 230
T L L +NF E + LV FYAPWC HCKK+ P + A + K I
Sbjct: 391 TWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHF-TATADAFKDDRKI 449
Query: 231 PLAKVDATAE--TDLAKRFDVSGYPTLKIFRKGR-PYDYNGPREKYGIVDYM 279
A VD + DL ++ V GYPT + G+ Y+ R + G +Y+
Sbjct: 450 ACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYI 501
Score = 130 bits (327), Expect = 4e-30
Identities = 78/223 (34%), Positives = 117/223 (52%), Gaps = 13/223 (5%)
Query: 78 DKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGY 137
++ +L+ FYAPWC CK+ P ++K A L+ + + ++ + + V G+
Sbjct: 169 EEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGH-AVLAGMNVYSSEFENIKEEYSVRGF 227
Query: 138 PTIKILKKGQAV---DYEGSRTQEEIVAKVR-------EVSQPDWTPPPEVTLVLTKENF 187
PTI +KG+ + D GS T E+IV ++ +V + W LT E+F
Sbjct: 228 PTICYFEKGRFLFQYDNYGS-TAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDF 286
Query: 188 DEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKEL-SKRSPPIPLAKVDATAETDLAKR 246
D+ V + +LV F+APWCGHCKK+ PE+EKAA+ L + LA VDAT LA+R
Sbjct: 287 DQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAER 346
Query: 247 FDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKE 289
F +S +PTLK F+ G Y R K +++M PP E
Sbjct: 347 FHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPE 389
Score = 65.5 bits (158), Expect = 1e-10
Identities = 31/89 (34%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 525 GPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ--KGLVIAK 582
G V + + FD V + VL+ F+APWCGHCK+++P + A+ G+ V+A
Sbjct: 276 GSVYHLTDEDFDQFVKE-HSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA 334
Query: 583 MDATANDVPSDRYKVEGFPTIYFAPSGDK 611
+DAT N ++R+ + FPT+ + +G+K
Sbjct: 335 VDATVNKALAERFHISEFPTLKYFKNGEK 363
Score = 57.0 bits (136), Expect = 5e-08
Identities = 37/116 (31%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 59 KEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVA 118
+++ VL L NF + K L+ FYAPWC HCK+ P + A+ KD D I A
Sbjct: 394 EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKD-DRKIACA 452
Query: 119 KIDAT--SASVLASRFDVSGYPTIKILKKGQ-AVDYEGSRTQEEIVAKVREVSQPD 171
+D L + V GYPT G+ A Y+ RT+ +R + + D
Sbjct: 453 AVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGD 508
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/115 (30%), Positives = 57/115 (49%), Gaps = 7/115 (6%)
Query: 497 TLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCG 556
T + V K K P+ + P K+ V + K F ++ +K +LI FYAPWC
Sbjct: 127 TFKSIVAFLKDPKGPPLWEEDPGAKD---VVHLDSEKDFRRLLKKEEKPLLIMFYAPWCS 183
Query: 557 HCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPS--DRYKVEGFPTIYFAPSG 609
CK++ P + A + +G V+A M+ +++ + + Y V GFPTI + G
Sbjct: 184 MCKRMMPHFQKAATQLRGH--AVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKG 236
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/134 (27%), Positives = 63/134 (47%), Gaps = 8/134 (5%)
Query: 517 QPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQK 576
+P + + V +VG F + KK L+ FYAPWC HCK++ P + + A +K +
Sbjct: 389 EPTWEEQQTSVLHLVGDNFRE-TLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDR 447
Query: 577 GLVIAKMDAT--ANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDL---EHLSKFI 631
+ A +D N + V+G+PT ++ G K K++ +L ++
Sbjct: 448 KIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYG--KFAEKYDSDRTELGFTNYIRALR 505
Query: 632 EEHATKLSRTKEEL 645
E +L + KEEL
Sbjct: 506 EGDHERLGKKKEEL 519
>gi|28372543 protein disulfide isomerase-like, testis expressed
[Homo sapiens]
Length = 584
Score = 133 bits (335), Expect = 4e-31
Identities = 117/475 (24%), Positives = 214/475 (45%), Gaps = 26/475 (5%)
Query: 180 LVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATA 239
LVLT +++N ++V F+ P + LA E KA + + K I KVD T
Sbjct: 46 LVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDITI 105
Query: 240 ETDLAKRFDVSGYPTLKIFRKGR---PYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQV 296
E +L + F ++ P LK+F +G P G E +V ++ Q + + +QV
Sbjct: 106 EKELQQEFGITKAPELKLFFEGNRSEPISCKGVVESAALVVWLRRQISQKAFLFNSSEQV 165
Query: 297 QEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLV 356
EF+ ++I+G F+ + + + D + E T I +F V+ ++
Sbjct: 166 AEFVISRP-LVIVGFFQDLEEEVAELFYDVIKDFPELTFGVITIGNVIGRF-HVTLDSVL 223
Query: 357 VMQPEKFQSKYEPRSHMMDVQGSTQ--DSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPL 414
V + K ++ + + + Q + + DFV++Y ++ + ++ + L
Sbjct: 224 VFKKGKIVNRQKLINDSTNKQELNRVIKQHLTDFVIEYNTE---NKDLISELHIMSHMLL 280
Query: 415 VVVYYSVDFSF---DYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESG 471
V S + Y+ A++ +++K+L + D ADE K ++E
Sbjct: 281 FVSKSSESYGIIIQHYKLASKEFQNKILFILVD--------ADEPRNGRVFKYFRVTEVD 332
Query: 472 EDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKN-NKGPVKVV 530
+ S ++ M ++ ++L++F +F S+ +PK ++G VK +
Sbjct: 333 IPSVQILNLSSDARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWDQGLVKQL 392
Query: 531 VGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDV 590
VGK F+ +V D +KDV + FYAPW CK L P+ L +KY+ ++IAK+D TAND+
Sbjct: 393 VGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTANDI 452
Query: 591 PSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645
++ +P PSG ++ G+ L+ S F+E H ++EL
Sbjct: 453 --QLMYLDRYPFFRLFPSGSQQ--AVLYKGEHTLKGFSDFLESHIKTKIEDEDEL 503
Score = 47.0 bits (110), Expect = 5e-05
Identities = 51/188 (27%), Positives = 80/188 (42%), Gaps = 29/188 (15%)
Query: 71 NFDNFVADKDT-VLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLA 129
NF+ V DK+ V + FYAPW CK P E++ ++ I +AKID T+ +
Sbjct: 396 NFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHS-TIIIAKIDVTANDIQL 454
Query: 130 SRFDVSGYPTIKILKKG--QAVDYEGSRT--------QEEIVAKVREVSQPDWTPPPEVT 179
D YP ++ G QAV Y+G T + I K+ + E
Sbjct: 455 MYLD--RYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIED----------EDE 502
Query: 180 LVLTKENFDEVVNDADIILVEFYAPWC--GHCKKLAPEYEKAAKELSKRSPPIPLAKVDA 237
L+ ++N EV+ + +++ E P G ++ +PE E K +SK P K
Sbjct: 503 LLSVEQN--EVIEE-EVLAEEKEVPMMRKGLPEQQSPELENMTKYVSKLEEPAGKKKTSE 559
Query: 238 TAETDLAK 245
+AK
Sbjct: 560 EVVVVVAK 567
>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
Length = 454
Score = 103 bits (258), Expect = 4e-22
Identities = 57/146 (39%), Positives = 84/146 (57%), Gaps = 4/146 (2%)
Query: 185 ENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA 244
E+F E ND DI LV+FYAPWCGHCKKL P + + E+ P+ + K+DAT+ + +A
Sbjct: 33 ESFKENRND-DIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIA 91
Query: 245 KRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGD 304
F V GYPT+K+ + Y+Y GPR K I+++ SG + L +Q+ E ++
Sbjct: 92 SEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRP-LPSQQMFEHMQKRH 150
Query: 305 DVIIIGVFKGESDPAYQQYQDAANNL 330
V V+ G P ++Y DAA+ L
Sbjct: 151 RVFF--VYVGGESPLKEKYIDAASEL 174
Score = 91.3 bits (225), Expect = 3e-18
Identities = 42/89 (47%), Positives = 58/89 (65%)
Query: 80 DTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPT 139
D L++FYAPWCGHCK+ P + ++ +K P+ V K+DATS S +AS F V GYPT
Sbjct: 42 DIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPT 101
Query: 140 IKILKKGQAVDYEGSRTQEEIVAKVREVS 168
IK+LK A +Y G RT+++I+ VS
Sbjct: 102 IKLLKGDLAYNYRGPRTKDDIIEFAHRVS 130
Score = 62.4 bits (150), Expect = 1e-09
Identities = 27/58 (46%), Positives = 39/58 (67%), Gaps = 1/58 (1%)
Query: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLV-IAKMDATANDVPSDRYKVEGFPTI 603
L++FYAPWCGHCK+LEP++N + + K V + KMDAT+ + + V G+PTI
Sbjct: 45 LVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTI 102
>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
[Homo sapiens]
Length = 406
Score = 103 bits (258), Expect = 4e-22
Identities = 62/194 (31%), Positives = 100/194 (51%), Gaps = 8/194 (4%)
Query: 172 WTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSP--- 228
+TP L EN DE++N+AD+ LV FYA WC + L P +E+A+ + + P
Sbjct: 24 FTPVTTEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNEN 83
Query: 229 PIPLAKVDATAETDLAKRFDVSGYPTLKIFRKG--RPYDYNGPREKYGIVDYMIEQSGPP 286
+ A+VD +D+A+R+ +S YPTLK+FR G +Y G R + DY+ +Q P
Sbjct: 84 QVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDP 143
Query: 287 SKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAK 346
+EI L ++ D IIG F+ + Y+ ++ AN L +D F F +++K
Sbjct: 144 IQEIRDLAEITTL--DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFG-DVSK 200
Query: 347 FLKVSQGQLVVMQP 360
+ S ++ P
Sbjct: 201 PERYSGDNIIYKPP 214
Score = 63.2 bits (152), Expect = 7e-10
Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 5/105 (4%)
Query: 67 LNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDP---PIPVAKIDAT 123
L+ N D + + D L+ FYA WC + P +E+ ++++K++ P + A++D
Sbjct: 34 LDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCD 93
Query: 124 SASVLASRFDVSGYPTIKILKKGQAV--DYEGSRTQEEIVAKVRE 166
S +A R+ +S YPT+K+ + G + +Y G R+ + + +R+
Sbjct: 94 QHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQ 138
Score = 40.4 bits (93), Expect = 0.005
Identities = 20/91 (21%), Positives = 45/91 (49%), Gaps = 6/91 (6%)
Query: 547 LIEFYAPWCGHCKQLEPVYNS----LAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPT 602
L+ FYA WC + L P++ + +++ + +V A++D + + RY++ +PT
Sbjct: 50 LVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPT 109
Query: 603 IYFAPSGDKKNPVKFEGGDRDLEHLSKFIEE 633
+ +G + G R ++ L+ +I +
Sbjct: 110 LKLFRNGMMMK--REYRGQRSVKALADYIRQ 138
>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
sapiens]
Length = 793
Score = 94.0 bits (232), Expect = 4e-19
Identities = 53/200 (26%), Positives = 100/200 (50%), Gaps = 19/200 (9%)
Query: 74 NFVA-DKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRF 132
NF A DK+ L++F+APWC C+ PE + +N+L + + +D T L + +
Sbjct: 462 NFPANDKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQ---LKFGTLDCTVHEGLCNMY 518
Query: 133 DVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVN 192
++ YPT + + +YEG + E+I+ + ++ P + LT F+E+V
Sbjct: 519 NIQAYPTTVVFNQSNIHEYEGHHSAEQILEFIEDLMNPS-------VVSLTPTTFNELVT 571
Query: 193 DA---DIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDV 249
++ +V+FY+PWC C+ L PE+++ A+ L+ I + +D + +V
Sbjct: 572 QRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGL---INVGSIDCQQYHSFCAQENV 628
Query: 250 SGYPTLKIF--RKGRPYDYN 267
YP ++ F + + Y Y+
Sbjct: 629 QRYPEIRFFPPKSNKAYHYH 648
Score = 83.2 bits (204), Expect = 7e-16
Identities = 63/234 (26%), Positives = 103/234 (44%), Gaps = 22/234 (9%)
Query: 33 NRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADK---DTVLLEFYAP 89
N+ N E E E E +DL V+ L F+ V + + +++FY+P
Sbjct: 530 NQSNIHEYEGHHSAEQILEFIEDLM---NPSVVSLTPTTFNELVTQRKHNEVWMVDFYSP 586
Query: 90 WCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKIL--KKGQ 147
WC C+ PE++++A L I V ID ++ +V YP I+ K +
Sbjct: 587 WCHPCQVLMPEWKRMARTLTGL---INVGSIDCQQYHSFCAQENVQRYPEIRFFPPKSNK 643
Query: 148 AVDYEGSRTQEEIVAKVREVSQPDWTPP--PEVTLVLTKENFDE-VVNDADIILVEFYAP 204
A Y +R W P+V+ LT + F E V+ + +++FYAP
Sbjct: 644 AYHYHSYNGWNRDAYSLRI-----WGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAP 698
Query: 205 WCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIF 258
WCG C+ APE+E A+ + + + KVD A ++ + YPT+K +
Sbjct: 699 WCGPCQNFAPEFELLARMIKGK---VKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/190 (26%), Positives = 87/190 (45%), Gaps = 18/190 (9%)
Query: 99 PEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAVDYE---GSR 155
PE +K+ +LK+ I V + D +SA + S V P++ + K +YE G +
Sbjct: 382 PELKKLKTLLKNDH--IQVGRFDCSSAPDICSNLYVF-QPSLAVFKGQGTKEYEIHHGKK 438
Query: 156 TQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPE 215
+I+A +E T L +NF ND + LV+F+APWC C+ L PE
Sbjct: 439 ILYDILAFAKESVNSHVT-------TLGPQNFP--ANDKEPWLVDFFAPWCPPCRALLPE 489
Query: 216 YEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGI 275
+A+ L + + +D T L +++ YPT +F + ++Y G I
Sbjct: 490 LRRASNLLYGQ---LKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQI 546
Query: 276 VDYMIEQSGP 285
++++ + P
Sbjct: 547 LEFIEDLMNP 556
Score = 65.1 bits (157), Expect = 2e-10
Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 5/118 (4%)
Query: 176 PEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235
PE+ + L + FD VN ++ V FY+P C HC LAP + AKE+ + + V
Sbjct: 129 PEI-ITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGL---LRIGAV 184
Query: 236 DATAETDLAKRFDVSGYPTLKIFRKG-RPYDYNGPREKYGIVDYMIEQSGPPSKEILT 292
+ + L + V+ YP+L IFR G P Y+G R K +V + ++ E+ T
Sbjct: 185 NCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVRSTVTELWT 242
Score = 54.7 bits (130), Expect = 3e-07
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 9/145 (6%)
Query: 35 ENAIEDEEEEEEEDDDEEEDDLEVKEENG-VLVLNDANFDNFVADKDTVLLEFYAPWCGH 93
E +ED + + E + D + +++ ++ L FD V + + FY+P C H
Sbjct: 101 EKGLEDNQGGQYESWNYYRYDFGIYDDDPEIITLERREFDAAVNSGELWFVNFYSPGCSH 160
Query: 94 CKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQA-VDYE 152
C AP + A K+ D + + ++ +L V+ YP++ I + G A V Y
Sbjct: 161 CHDLAPTWRDFA---KEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYH 217
Query: 153 GSRTQEEIVA----KVREVSQPDWT 173
G R++E +V+ VR WT
Sbjct: 218 GDRSKESLVSFAMQHVRSTVTELWT 242
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/118 (28%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 533 KTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPS 592
+TF V+ K +I+FYAPWCG C+ P + LA+ KG+ + K+D A
Sbjct: 678 QTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGK--VKAGKVDCQAYAQTC 735
Query: 593 DRYKVEGFPTI-YFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKL----SRTKEEL 645
+ + +PT+ ++ K+N + + RD + ++ I E L R K+EL
Sbjct: 736 QKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAIAALISEKLETLRNQGKRNKDEL 793
Score = 43.1 bits (100), Expect = 8e-04
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 5/87 (5%)
Query: 548 IEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAP 607
+ FY+P C HC L P + AK+ G L I ++ + + V +P+++
Sbjct: 151 VNFYSPGCSHCHDLAPTWRDFAKEVDGL--LRIGAVNCGDDRMLCRMKGVNSYPSLFIFR 208
Query: 608 SGDKKNPVKFEGGDRDLEHLSKFIEEH 634
SG PVK+ GDR E L F +H
Sbjct: 209 SG--MAPVKYH-GDRSKESLVSFAMQH 232
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/92 (28%), Positives = 47/92 (51%), Gaps = 8/92 (8%)
Query: 543 KKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFP- 601
K+ L++F+APWC C+ L P + GQ L +D T ++ + Y ++ +P
Sbjct: 468 KEPWLVDFFAPWCPPCRALLPELRRASNLLYGQ--LKFGTLDCTVHEGLCNMYNIQAYPT 525
Query: 602 TIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEE 633
T+ F ++ N ++E G E + +FIE+
Sbjct: 526 TVVF----NQSNIHEYE-GHHSAEQILEFIED 552
Score = 37.0 bits (84), Expect = 0.056
Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 6/94 (6%)
Query: 534 TFDSIVMDPKKDV--LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVP 591
TF+ +V K + +++FY+PWC C+ L P + +A+ G + + +D
Sbjct: 565 TFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGL--INVGSIDCQQYHSF 622
Query: 592 SDRYKVEGFPTIYFAPSGDKK--NPVKFEGGDRD 623
+ V+ +P I F P K + + G +RD
Sbjct: 623 CAQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRD 656
>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
Length = 280
Score = 65.1 bits (157), Expect = 2e-10
Identities = 35/111 (31%), Positives = 60/111 (54%), Gaps = 7/111 (6%)
Query: 62 NGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKID 121
+ V V+ D N+ + + ++EFYAPWC C+ PE+E A +D + + +AK+D
Sbjct: 29 SNVRVITDENWRELL--EGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLE--VNIAKVD 84
Query: 122 ATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDW 172
T L+ RF ++ PTI K G+ Y+G RT+++ + +S +W
Sbjct: 85 VTEQPGLSGRFIITALPTIYHCKDGEFRRYQGPRTKKDF---INFISDKEW 132
Score = 63.2 bits (152), Expect = 7e-10
Identities = 34/102 (33%), Positives = 57/102 (55%), Gaps = 4/102 (3%)
Query: 181 VLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAE 240
V+T EN+ E++ ++EFYAPWC C+ L PE+E A+ + +AKVD T +
Sbjct: 33 VITDENWRELLEGD--WMIEFYAPWCPACQNLQPEWESFAE--WGEDLEVNIAKVDVTEQ 88
Query: 241 TDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQ 282
L+ RF ++ PT+ + G Y GPR K ++++ ++
Sbjct: 89 PGLSGRFIITALPTIYHCKDGEFRRYQGPRTKKDFINFISDK 130
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 4/93 (4%)
Query: 518 PVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKG 577
P + V+V+ + + ++ + D +IEFYAPWC C+ L+P + S A ++
Sbjct: 22 PWTHGRRSNVRVITDENWRELL---EGDWMIEFYAPWCPACQNLQPEWESFA-EWGEDLE 77
Query: 578 LVIAKMDATANDVPSDRYKVEGFPTIYFAPSGD 610
+ IAK+D T S R+ + PTIY G+
Sbjct: 78 VNIAKVDVTEQPGLSGRFIITALPTIYHCKDGE 110
>gi|119395727 cardiac calsequestrin 2 precursor [Homo sapiens]
Length = 399
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/186 (24%), Positives = 89/186 (47%), Gaps = 10/186 (5%)
Query: 182 LTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEY-------EKAAKELSKRSPPIPLAK 234
L+++NF +V+ D++ + ++ P K ++ E A+ L ++ I
Sbjct: 37 LSEKNFKQVLKKYDLLCLYYHEPVSSD-KVTQKQFQLKEIVLELVAQVLEHKA--IGFVM 93
Query: 235 VDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLK 294
VDA E LAK+ +L I + R +++G +V+++++ P + I +
Sbjct: 94 VDAKKEAKLAKKLGFDEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIISSKL 153
Query: 295 QVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQ 354
+VQ F + D + +IG FK E Y+ +++AA + + KF TF +AK L + +
Sbjct: 154 EVQAFERIEDYIKLIGFFKSEDSEYYKAFEEAAEHFQPYIKFFATFDKGVAKKLSLKMNE 213
Query: 355 LVVMQP 360
+ +P
Sbjct: 214 VDFYEP 219
Score = 37.0 bits (84), Expect = 0.056
Identities = 60/281 (21%), Positives = 115/281 (40%), Gaps = 31/281 (11%)
Query: 64 VLVLNDANFDNFVADKDTVLLEFYAPWCGHC---KQFAPE---YEKIANILKDKDPPIPV 117
V+ L++ NF + D + L ++ P KQF + E +A +L+ K I
Sbjct: 34 VVSLSEKNFKQVLKKYDLLCLYYHEPVSSDKVTQKQFQLKEIVLELVAQVLEHK--AIGF 91
Query: 118 AKIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPE 177
+DA + LA + ++ ILK + ++++G + +V + ++ + P
Sbjct: 92 VMVDAKKEAKLAKKLGFDEEGSLYILKGDRTIEFDGEFAADVLVEFLLDLIE---DPVEI 148
Query: 178 VTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDA 237
++ L + F+ +E Y G K EY KA +E ++ P K A
Sbjct: 149 ISSKLEVQAFER---------IEDYIKLIGFFKSEDSEYYKAFEEAAEHFQ--PYIKFFA 197
Query: 238 TAETDLAKRF-----DVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILT 292
T + +AK+ +V Y P N P + +V+++ E P + L
Sbjct: 198 TFDKGVAKKLSLKMNEVDFYEPFMDEPIAIP---NKPYTEEELVEFVKEHQRPTLRR-LR 253
Query: 293 LKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLRED 333
+++ E +D + I I F +SDP ++ + + D
Sbjct: 254 PEEMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARD 294
Score = 29.6 bits (65), Expect = 9.0
Identities = 10/27 (37%), Positives = 19/27 (70%)
Query: 25 EGPDEDSSNRENAIEDEEEEEEEDDDE 51
E DED + +N+ E++ ++ ++DDDE
Sbjct: 373 EDDDEDDDDDDNSDEEDNDDSDDDDDE 399
>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
Length = 958
Score = 61.6 bits (148), Expect = 2e-09
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 4/111 (3%)
Query: 530 VVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATAND 589
V TF +V+ K+DVL+ +YAPWCG C L ++ LA+ +A++D + ND
Sbjct: 668 VTTDTFWEVVLQ-KQDVLLLYYAPWCGFCPSLNHIFIQLARNLP-MDTFTVARIDVSQND 725
Query: 590 VPSDRYKVEGFPTIYFAPSGDKKNPVKF-EGGDRDLEHLSKFIEEHATKLS 639
+P + + V+ PT+ F P K VK+ E L +L +FI H+ S
Sbjct: 726 LPWE-FMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPAS 775
Score = 44.3 bits (103), Expect = 4e-04
Identities = 32/119 (26%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 174 PPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLA 233
P + +T + F EVV +L+ +YAPWCG C L + + A+ L + +A
Sbjct: 660 PSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDT--FTVA 717
Query: 234 KVDATAETDLAKRFDVSGYPTLKIFRKGR-----PYDYNGPREKYGIVDYMIEQSGPPS 287
++D ++ DL F V PT+ F R Y + P ++ +++ S P S
Sbjct: 718 RID-VSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPAS 775
Score = 42.7 bits (99), Expect = 0.001
Identities = 36/150 (24%), Positives = 68/150 (45%), Gaps = 9/150 (6%)
Query: 190 VVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDV 249
V D++++L+ FYAPWCG E E+AA LS + + + + K F
Sbjct: 121 VRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFY 180
Query: 250 SGYPTLKIF-RKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVII 308
+P + ++ R P +Y GP ++ + + P I + ++ +FL + + +
Sbjct: 181 --FPVIYLYHRSFGPIEYKGPMSAV-YIEKFVRRVMKPLLYIPSQSELLDFLSNYEPG-V 236
Query: 309 IGVFKGESDPAYQQY----QDAANNLREDY 334
+G F+ P Y A ++L++DY
Sbjct: 237 LGYFEFSGSPQPPGYLTFFTSALHSLKKDY 266
Score = 35.8 bits (81), Expect = 0.13
Identities = 26/70 (37%), Positives = 34/70 (48%), Gaps = 5/70 (7%)
Query: 72 FDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIA-NILKDKDPPIPVAKIDATSASVLAS 130
F V K VLL +YAPWCG C + ++A N+ D VA+ID S + L
Sbjct: 673 FWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMD---TFTVARID-VSQNDLPW 728
Query: 131 RFDVSGYPTI 140
F V PT+
Sbjct: 729 EFMVDRLPTV 738
Score = 35.4 bits (80), Expect = 0.16
Identities = 16/34 (47%), Positives = 20/34 (58%)
Query: 78 DKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDK 111
D + VLL FYAPWCG E E+ A+ L D+
Sbjct: 124 DSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQ 157
>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
Length = 166
Score = 60.5 bits (145), Expect = 5e-09
Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 3/78 (3%)
Query: 188 DEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRF 247
D VVN ++V+F+A WCG CK L P EK ++K+ + +AKVD TDLA +
Sbjct: 72 DRVVNSETPVVVDFHAQWCGPCKILGPRLEKM---VAKQHGKVVMAKVDIDDHTDLAIEY 128
Query: 248 DVSGYPTLKIFRKGRPYD 265
+VS PT+ + G D
Sbjct: 129 EVSAVPTVLAMKNGDVVD 146
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/96 (29%), Positives = 54/96 (56%), Gaps = 4/96 (4%)
Query: 73 DNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRF 132
D V + V+++F+A WCG CK P EK ++ + + +AK+D + LA +
Sbjct: 72 DRVVNSETPVVVDFHAQWCGPCKILGPRLEK---MVAKQHGKVVMAKVDIDDHTDLAIEY 128
Query: 133 DVSGYPTIKILKKGQAVD-YEGSRTQEEIVAKVREV 167
+VS PT+ +K G VD + G + ++++ A ++++
Sbjct: 129 EVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKL 164
Score = 50.1 bits (118), Expect = 6e-06
Identities = 31/102 (30%), Positives = 54/102 (52%), Gaps = 5/102 (4%)
Query: 532 GKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVP 591
G F V++ + V+++F+A WCG CK L P + K G+ +V+AK+D +
Sbjct: 67 GPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGK--VVMAKVDIDDHTDL 124
Query: 592 SDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEE 633
+ Y+V PT+ +GD + KF G +D + L F+++
Sbjct: 125 AIEYEVSAVPTVLAMKNGDVVD--KFV-GIKDEDQLEAFLKK 163
>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
sapiens]
Length = 604
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/90 (31%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 172 WTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIP 231
++P +TL+ V+ VEF+A WCGHC AP ++ A+++ P +
Sbjct: 36 YSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALY 95
Query: 232 LAKVDATAETDLA--KRFDVSGYPTLKIFR 259
LA +D ET+ A + F++ G+PT++ F+
Sbjct: 96 LAALDCAEETNSAVCRDFNIPGFPTVRFFK 125
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/63 (34%), Positives = 38/63 (60%), Gaps = 2/63 (3%)
Query: 84 LEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDAT--SASVLASRFDVSGYPTIK 141
+EF+A WCGHC FAP ++ +A +K P + +A +D + S + F++ G+PT++
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 142 ILK 144
K
Sbjct: 123 FFK 125
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 526 PVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKG-QKGLVIAKMD 584
P+ ++ T V+ + +EF+A WCGHC P + +LA+ K + L +A +D
Sbjct: 41 PLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALD 100
Query: 585 AT--ANDVPSDRYKVEGFPTIYF 605
N + + GFPT+ F
Sbjct: 101 CAEETNSAVCRDFNIPGFPTVRF 123
>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
sapiens]
Length = 747
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/90 (31%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 172 WTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIP 231
++P +TL+ V+ VEF+A WCGHC AP ++ A+++ P +
Sbjct: 36 YSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALY 95
Query: 232 LAKVDATAETDLA--KRFDVSGYPTLKIFR 259
LA +D ET+ A + F++ G+PT++ F+
Sbjct: 96 LAALDCAEETNSAVCRDFNIPGFPTVRFFK 125
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/63 (34%), Positives = 38/63 (60%), Gaps = 2/63 (3%)
Query: 84 LEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDAT--SASVLASRFDVSGYPTIK 141
+EF+A WCGHC FAP ++ +A +K P + +A +D + S + F++ G+PT++
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 142 ILK 144
K
Sbjct: 123 FFK 125
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 526 PVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKG-QKGLVIAKMD 584
P+ ++ T V+ + +EF+A WCGHC P + +LA+ K + L +A +D
Sbjct: 41 PLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALD 100
Query: 585 AT--ANDVPSDRYKVEGFPTIYF 605
N + + GFPT+ F
Sbjct: 101 CAEETNSAVCRDFNIPGFPTVRF 123
>gi|227430327 calsequestrin 1 [Homo sapiens]
Length = 396
Score = 53.9 bits (128), Expect = 4e-07
Identities = 32/139 (23%), Positives = 69/139 (49%), Gaps = 2/139 (1%)
Query: 217 EKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIV 276
E AA+ L + + VD+ + +AK+ ++ ++ +F+ +Y+G IV
Sbjct: 93 ELAAQVLEDKG--VGFGLVDSEKDAAVAKKLGLTEVDSMYVFKGDEVIEYDGEFSADTIV 150
Query: 277 DYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKF 336
+++++ P + I +++Q F D++ +IG FK + Y+ ++DAA F
Sbjct: 151 EFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAFEDAAEEFHPYIPF 210
Query: 337 HHTFSTEIAKFLKVSQGQL 355
TF +++AK L + ++
Sbjct: 211 FATFDSKVAKKLTLKLNEI 229
>gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo
sapiens]
Length = 820
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/193 (23%), Positives = 93/193 (48%), Gaps = 22/193 (11%)
Query: 32 SNRENAIEDEEEEEEEDDDEEEDDLEVKEENG----------------VLVLNDANFDNF 75
S+ EN + EE +E+ED+D E D++V+++ + L + F+
Sbjct: 340 SHVENNMHIEEIQEDEDNDMEGPDIDVQDDEVAETVFRDRKRKLPLELTVELTEETFNAT 399
Query: 76 VADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVS 135
V D+++L FYA W F Y +A LK + + +I+ S + ++ +V+
Sbjct: 400 VMASDSIVL-FYAGWQAVSMAFLQSYIDVAVKLKGTSTML-LTRINCADWSDVCTKQNVT 457
Query: 136 GYPTIKILKKGQ-AVDYEGSRTQEEIV--AKVREVSQP-DWTPPPEVTLVLTKENFDEVV 191
+P IK+ KKG+ V Y G E+++ ++ +S P + T E L+ E + +++
Sbjct: 458 EFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQEAEEYLSGELYKDLI 517
Query: 192 NDADIILVEFYAP 204
+ + ++ ++P
Sbjct: 518 LYSSVSVLGLFSP 530
>gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo
sapiens]
Length = 825
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/193 (23%), Positives = 93/193 (48%), Gaps = 22/193 (11%)
Query: 32 SNRENAIEDEEEEEEEDDDEEEDDLEVKEENG----------------VLVLNDANFDNF 75
S+ EN + EE +E+ED+D E D++V+++ + L + F+
Sbjct: 345 SHVENNMHIEEIQEDEDNDMEGPDIDVQDDEVAETVFRDRKRKLPLELTVELTEETFNAT 404
Query: 76 VADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVS 135
V D+++L FYA W F Y +A LK + + +I+ S + ++ +V+
Sbjct: 405 VMASDSIVL-FYAGWQAVSMAFLQSYIDVAVKLKGTSTML-LTRINCADWSDVCTKQNVT 462
Query: 136 GYPTIKILKKGQ-AVDYEGSRTQEEIV--AKVREVSQP-DWTPPPEVTLVLTKENFDEVV 191
+P IK+ KKG+ V Y G E+++ ++ +S P + T E L+ E + +++
Sbjct: 463 EFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQEAEEYLSGELYKDLI 522
Query: 192 NDADIILVEFYAP 204
+ + ++ ++P
Sbjct: 523 LYSSVSVLGLFSP 535
>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
Length = 698
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 3/87 (3%)
Query: 61 ENGVLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAK 119
E+ V VL+ + A+ L++FY+ WCGHC +AP + +A ++D I VA
Sbjct: 60 EDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAA 119
Query: 120 IDATSA--SVLASRFDVSGYPTIKILK 144
+D + +D+ YPT + K
Sbjct: 120 LDCMEEKNQAVCHDYDIHFYPTFRYFK 146
Score = 46.2 bits (108), Expect = 9e-05
Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 2/70 (2%)
Query: 192 NDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA--KRFDV 249
N + LV+FY+ WCGHC AP + A ++ + I +A +D E + A +D+
Sbjct: 77 NSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDI 136
Query: 250 SGYPTLKIFR 259
YPT + F+
Sbjct: 137 HFYPTFRYFK 146
Score = 40.8 bits (94), Expect = 0.004
Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 9/97 (9%)
Query: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLV-IAKMDA--TANDVPSDRYKVEGFPTI 603
L++FY+ WCGHC P + +LA + + +A +D N Y + +PT
Sbjct: 83 LVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTF 142
Query: 604 YFAPSGDKK--NPVKFEGGDRDL----EHLSKFIEEH 634
+ + K+ F+G DR+L + + F++ H
Sbjct: 143 RYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNH 179
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/99 (28%), Positives = 50/99 (50%), Gaps = 7/99 (7%)
Query: 527 VKVVVGKTFDSIVMDPKKD--VLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMD 584
VK + KT +D D V+++F A WCG CK ++P ++SL++KY ++ ++D
Sbjct: 2 VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKY---SNVIFLEVD 58
Query: 585 ATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRD 623
+ +V+ PT F G K +F G +++
Sbjct: 59 VDDCQDVASECEVKCMPTFQFFKKGQKVG--EFSGANKE 95
Score = 47.4 bits (111), Expect = 4e-05
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 4/86 (4%)
Query: 82 VLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIK 141
V+++F A WCG CK P + L +K + ++D +AS +V PT +
Sbjct: 23 VVVDFSATWCGPCKMIKPFFHS----LSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQ 78
Query: 142 ILKKGQAVDYEGSRTQEEIVAKVREV 167
KKGQ V +E++ A + E+
Sbjct: 79 FFKKGQKVGEFSGANKEKLEATINEL 104
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/87 (29%), Positives = 45/87 (51%), Gaps = 6/87 (6%)
Query: 178 VTLVLTKENFDEVVNDAD--IILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235
V + +K F E ++ A +++V+F A WCG CK + P + LS++ + +V
Sbjct: 2 VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFH----SLSEKYSNVIFLEV 57
Query: 236 DATAETDLAKRFDVSGYPTLKIFRKGR 262
D D+A +V PT + F+KG+
Sbjct: 58 DVDDCQDVASECEVKCMPTFQFFKKGQ 84
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/127 (27%), Positives = 67/127 (52%), Gaps = 8/127 (6%)
Query: 488 MEPEEFDSDTLREFVTAFKKGK-LKPVIKSQPVPKNNKGPVKVVVGKT-FDSIVMDP-KK 544
++P+E DS E T K+G LKP ++ P+ +K VKV++ K F++ + + ++
Sbjct: 345 IQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDK--VKVILSKEDFEASLKEAGER 402
Query: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604
V ++F A WCG C+ + P +++L+ K+ + +V ++DA + + PT
Sbjct: 403 LVAVDFSATWCGPCRTIRPFFHALSVKH---EDVVFLEVDADNCEEVVRECAIMCVPTFQ 459
Query: 605 FAPSGDK 611
F +K
Sbjct: 460 FYKKEEK 466
Score = 44.3 bits (103), Expect = 4e-04
Identities = 36/145 (24%), Positives = 69/145 (47%), Gaps = 10/145 (6%)
Query: 27 PDEDSSNRENAIEDEEEEEEEDD-DEEEDDLEVKEENGV-LVLNDANFDNFV--ADKDTV 82
P ED S + ++E+ +E D EE+ +E E + V ++L+ +F+ + A + V
Sbjct: 347 PKEDDSPK--SLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLV 404
Query: 83 LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKI 142
++F A WCG C+ P + + L K + ++DA + + + PT +
Sbjct: 405 AVDFSATWCGPCRTIRPFF----HALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQF 460
Query: 143 LKKGQAVDYEGSRTQEEIVAKVREV 167
KK + VD +E++ A + E+
Sbjct: 461 YKKEEKVDELCGALKEKLEAVIAEL 485
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/116 (23%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 152 EGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDAD--IILVEFYAPWCGHC 209
E + ++E + K E + ++ +V ++L+KE+F+ + +A ++ V+F A WCG C
Sbjct: 358 EATPSKEGDILKPEEETM-EFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPC 416
Query: 210 KKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYD 265
+ + P + LS + + +VDA ++ + + PT + ++K D
Sbjct: 417 RTIRPFFH----ALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVD 468
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/127 (27%), Positives = 67/127 (52%), Gaps = 8/127 (6%)
Query: 488 MEPEEFDSDTLREFVTAFKKGK-LKPVIKSQPVPKNNKGPVKVVVGKT-FDSIVMDP-KK 544
++P+E DS E T K+G LKP ++ P+ +K VKV++ K F++ + + ++
Sbjct: 412 IQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDK--VKVILSKEDFEASLKEAGER 469
Query: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604
V ++F A WCG C+ + P +++L+ K+ + +V ++DA + + PT
Sbjct: 470 LVAVDFSATWCGPCRTIRPFFHALSVKH---EDVVFLEVDADNCEEVVRECAIMCVPTFQ 526
Query: 605 FAPSGDK 611
F +K
Sbjct: 527 FYKKEEK 533
Score = 44.3 bits (103), Expect = 4e-04
Identities = 36/145 (24%), Positives = 69/145 (47%), Gaps = 10/145 (6%)
Query: 27 PDEDSSNRENAIEDEEEEEEEDD-DEEEDDLEVKEENGV-LVLNDANFDNFV--ADKDTV 82
P ED S + ++E+ +E D EE+ +E E + V ++L+ +F+ + A + V
Sbjct: 414 PKEDDSPK--SLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLV 471
Query: 83 LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKI 142
++F A WCG C+ P + + L K + ++DA + + + PT +
Sbjct: 472 AVDFSATWCGPCRTIRPFF----HALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQF 527
Query: 143 LKKGQAVDYEGSRTQEEIVAKVREV 167
KK + VD +E++ A + E+
Sbjct: 528 YKKEEKVDELCGALKEKLEAVIAEL 552
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/116 (23%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 152 EGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDAD--IILVEFYAPWCGHC 209
E + ++E + K E + ++ +V ++L+KE+F+ + +A ++ V+F A WCG C
Sbjct: 425 EATPSKEGDILKPEEETM-EFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPC 483
Query: 210 KKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYD 265
+ + P + LS + + +VDA ++ + + PT + ++K D
Sbjct: 484 RTIRPFFH----ALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVD 535
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/127 (27%), Positives = 67/127 (52%), Gaps = 8/127 (6%)
Query: 488 MEPEEFDSDTLREFVTAFKKGK-LKPVIKSQPVPKNNKGPVKVVVGKT-FDSIVMDP-KK 544
++P+E DS E T K+G LKP ++ P+ +K VKV++ K F++ + + ++
Sbjct: 345 IQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDK--VKVILSKEDFEASLKEAGER 402
Query: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604
V ++F A WCG C+ + P +++L+ K+ + +V ++DA + + PT
Sbjct: 403 LVAVDFSATWCGPCRTIRPFFHALSVKH---EDVVFLEVDADNCEEVVRECAIMCVPTFQ 459
Query: 605 FAPSGDK 611
F +K
Sbjct: 460 FYKKEEK 466
Score = 44.3 bits (103), Expect = 4e-04
Identities = 36/145 (24%), Positives = 69/145 (47%), Gaps = 10/145 (6%)
Query: 27 PDEDSSNRENAIEDEEEEEEEDD-DEEEDDLEVKEENGV-LVLNDANFDNFV--ADKDTV 82
P ED S + ++E+ +E D EE+ +E E + V ++L+ +F+ + A + V
Sbjct: 347 PKEDDSPK--SLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLV 404
Query: 83 LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKI 142
++F A WCG C+ P + + L K + ++DA + + + PT +
Sbjct: 405 AVDFSATWCGPCRTIRPFF----HALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQF 460
Query: 143 LKKGQAVDYEGSRTQEEIVAKVREV 167
KK + VD +E++ A + E+
Sbjct: 461 YKKEEKVDELCGALKEKLEAVIAEL 485
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/116 (23%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 152 EGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDAD--IILVEFYAPWCGHC 209
E + ++E + K E + ++ +V ++L+KE+F+ + +A ++ V+F A WCG C
Sbjct: 358 EATPSKEGDILKPEEETM-EFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPC 416
Query: 210 KKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYD 265
+ + P + LS + + +VDA ++ + + PT + ++K D
Sbjct: 417 RTIRPFFH----ALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVD 468
>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
sapiens]
Length = 349
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 6/110 (5%)
Query: 175 PPEVTLV--LTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPL 232
PPE + V +T N+ V+ +++FYAPWC C++ E+E AK + I +
Sbjct: 33 PPEQSRVQPMTASNWTLVMEGE--WMLKFYAPWCPSCQQTDSEWEAFAK--NGEILQISV 88
Query: 233 AKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQ 282
KVD E L+ RF V+ P + G Y GP + +Y++E+
Sbjct: 89 GKVDVIQEPGLSGRFFVTTLPAFFHAKDGIFRRYRGPGIFEDLQNYILEK 138
Score = 43.5 bits (101), Expect = 6e-04
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 8/104 (7%)
Query: 83 LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKI 142
+L+FYAPWC C+Q E+E A + I V K+D L+ RF V+ P
Sbjct: 56 MLKFYAPWCPSCQQTDSEWEAFAK--NGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFH 113
Query: 143 LKKGQAVDYEG----SRTQEEIVAKVREVSQP--DWTPPPEVTL 180
K G Y G Q I+ K + +P W P +T+
Sbjct: 114 AKDGIFRRYRGPGIFEDLQNYILEKKWQSVEPLTGWKSPASLTM 157
Score = 37.4 bits (85), Expect = 0.043
Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFA 606
+++FYAPWC C+Q + + + AK + + + + K+D S R+ V P + A
Sbjct: 56 MLKFYAPWCPSCQQTDSEWEAFAKNGEILQ-ISVGKVDVIQEPGLSGRFFVTTLPAFFHA 114
Query: 607 PSG 609
G
Sbjct: 115 KDG 117
Score = 33.5 bits (75), Expect = 0.62
Identities = 17/41 (41%), Positives = 28/41 (68%), Gaps = 2/41 (4%)
Query: 24 AEGPDEDSSNREN--AIEDEEEEEEEDDDEEEDDLEVKEEN 62
AE +DS+ EN ++ D+EEE+E+ DE+E + E +E+N
Sbjct: 244 AEEEKDDSNEEENKDSLVDDEEEKEDLGDEDEAEEEEEEDN 284
>gi|94421469 disulfide isomerase [Homo sapiens]
Length = 360
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 4/72 (5%)
Query: 192 NDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSG 251
N +D LV FY PWC LAP + L + P + +DA+ + L+ RF
Sbjct: 206 NGSDCTLVLFYTPWCRFSASLAPHF----NSLPRAFPALHFLALDASQHSSLSTRFGTVA 261
Query: 252 YPTLKIFRKGRP 263
P + +F+ +P
Sbjct: 262 VPNILLFQGAKP 273
Score = 39.7 bits (91), Expect = 0.009
Identities = 27/85 (31%), Positives = 36/85 (42%), Gaps = 5/85 (5%)
Query: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFA 606
L+ FY PWC L P +NSL + + L +DA+ + S R+ P I
Sbjct: 212 LVLFYTPWCRFSASLAPHFNSLPRAF---PALHFLALDASQHSSLSTRFGTVAVPNILLF 268
Query: 607 PSGDKKNPVKFEGGDRDLEHLSKFI 631
K +F DR LE L FI
Sbjct: 269 QGA--KPMARFNHTDRTLETLKIFI 291
Score = 38.9 bits (89), Expect = 0.015
Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 8/118 (6%)
Query: 27 PDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEF 86
P EDS+N E+ ++ + EE + ++ +K N L D N D L+ F
Sbjct: 160 PTEDSNNTES-LKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPN---GSDCTLVLF 215
Query: 87 YAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144
Y PWC AP + N L P + +DA+ S L++RF P I + +
Sbjct: 216 YTPWCRFSASLAPHF----NSLPRAFPALHFLALDASQHSSLSTRFGTVAVPNILLFQ 269
>gi|95113651 glutaredoxin 3 [Homo sapiens]
Length = 335
Score = 43.9 bits (102), Expect = 5e-04
Identities = 17/70 (24%), Positives = 38/70 (54%), Gaps = 4/70 (5%)
Query: 196 IILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTL 255
+++V F+APW C ++ + EL+K P + K++A ++++++++S PT
Sbjct: 33 LLVVHFWAPWAPQCAQM----NEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISSVPTF 88
Query: 256 KIFRKGRPYD 265
F+ + D
Sbjct: 89 LFFKNSQKID 98
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/97 (24%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 79 KDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYP 138
K +++ F+APW C Q ++A L P + K++A ++ ++++S P
Sbjct: 31 KSLLVVHFWAPWAPQCAQMNEVMAELAKEL----PQVSFVKLEAEGVPEVSEKYEISSVP 86
Query: 139 TIKILKKGQAVDYEGSRTQEEIVAKV-REVSQPDWTP 174
T K Q +D E+ KV R S + P
Sbjct: 87 TFLFFKNSQKIDRLDGAHAPELTKKVQRHASSGSFLP 123
Score = 39.7 bits (91), Expect = 0.009
Identities = 25/105 (23%), Positives = 50/105 (47%), Gaps = 7/105 (6%)
Query: 532 GKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVP 591
G+ + + + K +++ F+APW C Q+ V LAK+ + K++A
Sbjct: 20 GQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL---PQVSFVKLEAEGVPEV 76
Query: 592 SDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHAT 636
S++Y++ PT F + K + + +G L+K ++ HA+
Sbjct: 77 SEKYEISSVPTFLFFKNSQKID--RLDGA--HAPELTKKVQRHAS 117
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 43.1 bits (100), Expect = 8e-04
Identities = 23/47 (48%), Positives = 30/47 (63%), Gaps = 1/47 (2%)
Query: 18 LLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDD-LEVKEENG 63
LL P E S+ E+ ED EEE+EEDD EEE+D ++VK+E G
Sbjct: 564 LLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEG 610
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,502,973
Number of Sequences: 37866
Number of extensions: 1227939
Number of successful extensions: 20808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 425
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 10283
Number of HSP's gapped (non-prelim): 5271
length of query: 645
length of database: 18,247,518
effective HSP length: 109
effective length of query: 536
effective length of database: 14,120,124
effective search space: 7568386464
effective search space used: 7568386464
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.