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Search of human proteins with 47551347
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47551347 protease, serine-like 1 [Homo sapiens]
(283 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47551347 protease, serine-like 1 [Homo sapiens] 602 e-172
gi|42544239 complement factor D preproprotein [Homo sapiens] 177 7e-45
gi|4885369 granzyme M precursor [Homo sapiens] 171 7e-43
gi|4503549 neutrophil elastase preproprotein [Homo sapiens] 157 1e-38
gi|21327705 stratum corneum chymotryptic enzyme preproprotein [H... 151 5e-37
gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Ho... 151 5e-37
gi|221625528 granzyme B precursor [Homo sapiens] 147 1e-35
gi|91823048 kallikrein 14 preproprotein [Homo sapiens] 144 1e-34
gi|11496281 kallikrein 13 precursor [Homo sapiens] 143 2e-34
gi|15529990 granzyme H [Homo sapiens] 142 3e-34
gi|71361688 myeloblastin [Homo sapiens] 142 3e-34
gi|4504235 granzyme K precursor [Homo sapiens] 142 4e-34
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens] 141 7e-34
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 141 7e-34
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot... 141 7e-34
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 139 2e-33
gi|11342670 azurocidin 1 preproprotein [Homo sapiens] 137 8e-33
gi|4503149 cathepsin G preproprotein [Homo sapiens] 137 1e-32
gi|5453676 granzyme A precursor [Homo sapiens] 137 1e-32
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens] 136 2e-32
gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens] 135 3e-32
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens] 135 5e-32
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s... 135 5e-32
gi|110815798 ovochymase 1 [Homo sapiens] 134 7e-32
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens] 132 3e-31
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 132 4e-31
gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens] 129 2e-30
gi|4502173 prostate specific antigen isoform 1 preproprotein [Ho... 129 3e-30
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote... 127 8e-30
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei... 127 8e-30
>gi|47551347 protease, serine-like 1 [Homo sapiens]
Length = 283
Score = 602 bits (1551), Expect = e-172
Identities = 283/283 (100%), Positives = 283/283 (100%)
Query: 1 MGLGLRGWGRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCG 60
MGLGLRGWGRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCG
Sbjct: 1 MGLGLRGWGRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCG 60
Query: 61 GFLLRARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHA 120
GFLLRARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHA
Sbjct: 61 GFLLRARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHA 120
Query: 121 NDICLLRLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKV 180
NDICLLRLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKV
Sbjct: 121 NDICLLRLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKV 180
Query: 181 RVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCG 240
RVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCG
Sbjct: 181 RVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCG 240
Query: 241 DPKTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRPPGEAA 283
DPKTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRPPGEAA
Sbjct: 241 DPKTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRPPGEAA 283
>gi|42544239 complement factor D preproprotein [Homo sapiens]
Length = 253
Score = 177 bits (450), Expect = 7e-45
Identities = 103/261 (39%), Positives = 141/261 (54%), Gaps = 12/261 (4%)
Query: 5 LRGWGRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLL 64
+ W R + V PP G +I+GG E H+RPYMASV+ G H CGG L+
Sbjct: 1 MHSWERLAVLVLLGAAACAAPPRG----RILGGREAEAHARPYMASVQLNGAHLCGGVLV 56
Query: 65 RARWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDIC 124
+WV+SAAHC V+LGAH LS EP+++++ + HPD P T +D+
Sbjct: 57 AEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLL 116
Query: 125 LLRLNGSAVLGPAVGLLRLPGRRA-RPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVL 183
LL+L+ A LGPAV LP +R R GT C VAGWG V+ P L + VL
Sbjct: 117 LLQLSEKATLGPAV--RPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVL 174
Query: 184 DPDVCN--SSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGD 241
D CN + G +T ++C +S+RR C DSGGPLVC G+V+ CG+
Sbjct: 175 DRATCNRRTHHDGAITERLMC---AESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGN 231
Query: 242 PKTPDVYTQVSAFVAWIWDVV 262
K P +YT+V+++ AWI V+
Sbjct: 232 RKKPGIYTRVASYAAWIDSVL 252
>gi|4885369 granzyme M precursor [Homo sapiens]
Length = 257
Score = 171 bits (433), Expect = 7e-43
Identities = 106/243 (43%), Positives = 140/243 (57%), Gaps = 11/243 (4%)
Query: 29 SWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVL 88
S+G QIIGG EV PHSRPYMAS++ G H CGG L+ +WV++AAHC + R + L VL
Sbjct: 21 SFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRMAQLRL-VL 79
Query: 89 GAHVLSTAEPTQQVFGIDALTTHPDYHPM-THANDICLLRLNGSAVLGPAVGLLRLPGRR 147
G H L + T F I A HP Y P+ ND+ LL+L+G + L LP +R
Sbjct: 80 GLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKR 136
Query: 148 ARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSS--WKGHLTLTMLCTRS 205
+ AGTRC +AGWG L L E ++VLD +CN+S W G L+ +M+C +
Sbjct: 137 -QVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCL-A 194
Query: 206 GDSHRRGFCSADSGGPLVC-RNRA-HGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVR 263
DS + C DSGGPLVC + R G++SFS C D P V T V+ +V+WI V
Sbjct: 195 ADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTG 254
Query: 264 RSS 266
RS+
Sbjct: 255 RSA 257
>gi|4503549 neutrophil elastase preproprotein [Homo sapiens]
Length = 267
Score = 157 bits (396), Expect = 1e-38
Identities = 97/276 (35%), Positives = 136/276 (49%), Gaps = 23/276 (8%)
Query: 9 GRPLLTVATALMLPVKPPAGS-WGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRAR 67
GR L + A +LP G+ ++I+GG PH+ P+M S++ G H CG L+
Sbjct: 4 GRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPN 63
Query: 68 WVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLR 127
+V+SAAHC ++ ++R VVLGAH LS EPT+QVF + + + Y P+ NDI +L+
Sbjct: 64 FVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFEN-GYDPVNLLNDIVILQ 122
Query: 128 LNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDV 187
LNGSA + V + +LP + R G +C GWG + + L E V V
Sbjct: 123 LNGSATINANVQVAQLPAQGRRLGN-GVQCLAMGWGLLGRNRGIASVLQELNVTV----- 176
Query: 188 CNSSWKGHLTLTMLCTRSG-----DSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDP 242
+T LC RS + G C DSG PLVC HG+ SF C
Sbjct: 177 ----------VTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASG 226
Query: 243 KTPDVYTQVSAFVAWIWDVVRRSSPQPGPLPGTTRP 278
PD + V+ FV WI +++RS P P P P
Sbjct: 227 LYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDP 262
>gi|21327705 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 151 bits (382), Expect = 5e-37
Identities = 91/235 (38%), Positives = 120/235 (51%), Gaps = 11/235 (4%)
Query: 31 GAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGA 90
G +II G S P+ ++ G Q HCGG L+ RWV++AAHC + V LG+
Sbjct: 27 GDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHC----KMNEYTVHLGS 82
Query: 91 HVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARP 150
L + Q HP Y TH ND+ L++LN A L V +RLP R P
Sbjct: 83 DTLG--DRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSR-CEP 139
Query: 151 PTAGTRCRVAGWGFVSDFE-ELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSH 209
P GT C V+GWG + + P LM V+++ P C +K L +MLC DS
Sbjct: 140 P--GTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDS- 196
Query: 210 RRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRR 264
++ C+ DSGGPLVCR GLVS+ CG P P VYTQV F WI D +++
Sbjct: 197 KKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKK 251
>gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 151 bits (382), Expect = 5e-37
Identities = 91/235 (38%), Positives = 120/235 (51%), Gaps = 11/235 (4%)
Query: 31 GAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGA 90
G +II G S P+ ++ G Q HCGG L+ RWV++AAHC + V LG+
Sbjct: 27 GDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHC----KMNEYTVHLGS 82
Query: 91 HVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARP 150
L + Q HP Y TH ND+ L++LN A L V +RLP R P
Sbjct: 83 DTLG--DRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSR-CEP 139
Query: 151 PTAGTRCRVAGWGFVSDFE-ELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSH 209
P GT C V+GWG + + P LM V+++ P C +K L +MLC DS
Sbjct: 140 P--GTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDS- 196
Query: 210 RRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRR 264
++ C+ DSGGPLVCR GLVS+ CG P P VYTQV F WI D +++
Sbjct: 197 KKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKK 251
>gi|221625528 granzyme B precursor [Homo sapiens]
Length = 247
Score = 147 bits (371), Expect = 1e-35
Identities = 102/259 (39%), Positives = 137/259 (52%), Gaps = 18/259 (6%)
Query: 10 RPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQH---HCGGFLLRA 66
+P+L + L+LP + AG +IIGGHE PHSRPYMA + Q CGGFL+R
Sbjct: 2 QPILLLLAFLLLP-RADAG----EIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRD 56
Query: 67 RWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLL 126
+V++AAHC+ + V LGAH + EPTQQ + HP Y+P +NDI LL
Sbjct: 57 DFVLTAAHCWGS----SINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLL 112
Query: 127 RLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPD 186
+L A AV LRLP +A+ G C VAGWG + + L E K+ V +
Sbjct: 113 QLERKAKRTRAVQPLRLPSNKAQ-VKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDR 171
Query: 187 VCNSSWKGHLTLTM-LCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTP 245
C S + + T+ LC + + F DSGGPLVC A G+VS+ G G P P
Sbjct: 172 KCESDLRHYYDSTIELCVGDPEIKKTSF-KGDSGGPLVCNKVAQGIVSY-GRNNGMP--P 227
Query: 246 DVYTQVSAFVAWIWDVVRR 264
T+VS+FV WI ++R
Sbjct: 228 RACTKVSSFVHWIKKTMKR 246
>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
Length = 267
Score = 144 bits (362), Expect = 1e-34
Identities = 88/234 (37%), Positives = 123/234 (52%), Gaps = 11/234 (4%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHH--CGGFLLRARWVVSAAHCFSHRDLRTGLVVLGA 90
+IIGGH T S+P+ A++ G + CGG LL +WV++AAHC R + V LG
Sbjct: 40 KIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHC--GRPILQ--VALGK 95
Query: 91 HVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARP 150
H L E TQQV + THP+Y+ TH ND+ LL+L A +G AV + + A P
Sbjct: 96 HNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPIEVTQACASP 155
Query: 151 PTAGTRCRVAGWGFVSD-FEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSH 209
GT CRV+GWG +S P L + + +VC ++ +T M+C
Sbjct: 156 ---GTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTITPGMVCAGVPQGG 212
Query: 210 RRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVR 263
+ C DSGGPLVCR + GLVS+ C P P VYT + + +WI + +R
Sbjct: 213 KDS-CQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWIEETMR 265
>gi|11496281 kallikrein 13 precursor [Homo sapiens]
Length = 277
Score = 143 bits (360), Expect = 2e-34
Identities = 85/239 (35%), Positives = 122/239 (51%), Gaps = 14/239 (5%)
Query: 36 GGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGL-VVLGAHVLS 94
GG+ PHS+P+ A++ G+ CGG L+ +WV++AAHC L+ GL V LG H L
Sbjct: 38 GGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHC-----LKEGLKVYLGKHALG 92
Query: 95 TAEPTQQVFGIDALTTHPDYHP----MTHANDICLLRLNGSAVLGPAVGLLRLPGRRARP 150
E +QV + HP+Y + H +DI LL L L + L L
Sbjct: 93 RVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLT 152
Query: 151 PTAGTRCRVAGWGFVSDFE-ELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSH 209
P GT CRV+GWG + + P L A +++ + C + G +T MLC + +
Sbjct: 153 P--GTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGG 210
Query: 210 RRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSSPQ 268
+ C DSGGPLVC +G+VS+ CG P P VYT+VS +V WI + +R+ Q
Sbjct: 211 KDS-CEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIRKYETQ 268
>gi|15529990 granzyme H [Homo sapiens]
Length = 246
Score = 142 bits (359), Expect = 3e-34
Identities = 100/259 (38%), Positives = 135/259 (52%), Gaps = 19/259 (7%)
Query: 10 RPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRF---GGQHHCGGFLLRA 66
+P L + L+ P G+ +IIGGHE PHSRPYMA V+F + CGG L+R
Sbjct: 2 QPFLLLLAFLLTP-----GAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRK 56
Query: 67 RWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLL 126
+V++AAHC + V LGAH + E TQQ + HP Y+P +NDI LL
Sbjct: 57 DFVLTAAHCQGS----SINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLL 112
Query: 127 RLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPD 186
+L A AV LRLP +A+ G C VAGWG+VS L L E + V
Sbjct: 113 QLERKAKWTTAVRPLRLPSSKAQ-VKPGQLCSVAGWGYVS-MSTLATTLQEVLLTVQKDC 170
Query: 187 VCNSSWKGHLT-LTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTP 245
C + G+ + T +C + GF DSGGPLVC++ A G++S+ G G P P
Sbjct: 171 QCERLFHGNYSRATEICVGDPKKTQTGF-KGDSGGPLVCKDVAQGILSY-GNKKGTP--P 226
Query: 246 DVYTQVSAFVAWIWDVVRR 264
VY +VS F+ WI ++R
Sbjct: 227 GVYIKVSHFLPWIKRTMKR 245
>gi|71361688 myeloblastin [Homo sapiens]
Length = 256
Score = 142 bits (358), Expect = 3e-34
Identities = 91/265 (34%), Positives = 136/265 (51%), Gaps = 15/265 (5%)
Query: 10 RPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQ---HHCGGFLLRA 66
RP +++L + + A+I+GGHE PHSRPYMAS++ G H CGG L+
Sbjct: 4 RPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHP 63
Query: 67 RWVVSAAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLL 126
+V++AAHC R VVLGAH + T EPTQQ F + + + +Y ND+ L+
Sbjct: 64 SFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLNDVLLI 122
Query: 127 RLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPD 186
+L+ A L +V ++LP ++ +P GT+C GWG V + PP + ++ L+
Sbjct: 123 QLSSPANLSASVATVQLP-QQDQPVPHGTQCLAMGWGRVGAHD--PPAQV---LQELNVT 176
Query: 187 VCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPD 246
V + H T + R + G C DSGGPL+C G+ SF C PD
Sbjct: 177 VVTFFCRPHNICTFVPRR-----KAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPD 231
Query: 247 VYTQVSAFVAWIWDVVRRSSPQPGP 271
+T+V+ +V WI +RR + P
Sbjct: 232 FFTRVALYVDWIRSTLRRVEAKGRP 256
>gi|4504235 granzyme K precursor [Homo sapiens]
Length = 264
Score = 142 bits (357), Expect = 4e-34
Identities = 89/233 (38%), Positives = 129/233 (55%), Gaps = 11/233 (4%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHC-FSHRDLRTGLVVLGAH 91
+IIGG EV+PHSRP+MAS+++GG H CGG L+ +WV++AAHC + ++ VVLGAH
Sbjct: 26 EIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAHCQYRFTKGQSPTVVLGAH 85
Query: 92 VLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPP 151
LS E ++Q I +NDI L++L +A L V +L + R
Sbjct: 86 SLSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHI--RSKTSL 143
Query: 152 TAGTRCRVAGWGFVSDFEELPPG--LMEAKVRVLDPDVCNSS--WKGHLTLTMLCTRSGD 207
+GT+C+V GWG +D + L P L E V VL +CNS + G +T +GD
Sbjct: 144 RSGTKCKVTGWG-ATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPFITKDMVCAGD 202
Query: 208 SH-RRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVS-AFVAWI 258
+ ++ C DSGGPL+C+ H +VS G CG P +YT ++ + WI
Sbjct: 203 AKGQKDSCKGDSGGPLICKGVFHAIVS-GGHECGVATKPGIYTLLTKKYQTWI 254
>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
Length = 304
Score = 141 bits (355), Expect = 7e-34
Identities = 85/235 (36%), Positives = 119/235 (50%), Gaps = 11/235 (4%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHV 92
+I+GG+ +S PY S+ G H CGG L+ +WVVSAAHC+ R V LG H
Sbjct: 80 KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKTRI----QVRLGEHN 134
Query: 93 LSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPPT 152
+ E +Q + HP Y+ T NDI L++L+ AV+ V + LP PP
Sbjct: 135 IKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLP---TAPPA 191
Query: 153 AGTRCRVAGWGFVSDF-EELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRR 211
AGT C ++GWG F + P L VL C +S+ G +T +M C + +
Sbjct: 192 AGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKD 251
Query: 212 GFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSS 266
C DSGGP+VC + G+VS+ G C P VYT+V +V WI D + +S
Sbjct: 252 S-CQRDSGGPVVCNGQLQGVVSW-GHGCAWKNRPGVYTKVYNYVDWIKDTIAANS 304
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 141 bits (355), Expect = 7e-34
Identities = 85/235 (36%), Positives = 119/235 (50%), Gaps = 11/235 (4%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHV 92
+I+GG+ +S PY S+ G H CGG L+ +WVVSAAHC+ R V LG H
Sbjct: 23 KIVGGYTCEENSLPYQVSLN-SGSHFCGGSLISEQWVVSAAHCYKTRI----QVRLGEHN 77
Query: 93 LSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPPT 152
+ E +Q + HP Y+ T NDI L++L+ AV+ V + LP PP
Sbjct: 78 IKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLP---TAPPA 134
Query: 153 AGTRCRVAGWGFVSDF-EELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRR 211
AGT C ++GWG F + P L VL C +S+ G +T +M C + +
Sbjct: 135 AGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGKD 194
Query: 212 GFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSS 266
C DSGGP+VC + G+VS+ G C P VYT+V +V WI D + +S
Sbjct: 195 S-CQRDSGGPVVCNGQLQGVVSW-GHGCAWKNRPGVYTKVYNYVDWIKDTIAANS 247
>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
[Homo sapiens]
Length = 256
Score = 141 bits (355), Expect = 7e-34
Identities = 87/246 (35%), Positives = 122/246 (49%), Gaps = 19/246 (7%)
Query: 31 GAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGA 90
G +++ G E PHS+P+ ++ G+ +CG L+ WV+SAAHC S R V LG
Sbjct: 19 GDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQS----RFMRVRLGE 74
Query: 91 HVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARP 150
H L + +Q+ + HP Y +H NDI LLRL A L P V LP R P
Sbjct: 75 HNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPHP 134
Query: 151 PTAGTRCRVAGWGFVSDFE-----------ELPPGLMEAKVRVLDPDVCNSSWKGHLTLT 199
G C V+GWG VS E LP L A + ++ C+ S+ G LT T
Sbjct: 135 ---GEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSYPGRLTNT 191
Query: 200 MLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIW 259
M+C + C DSGGPLVC G+VS+ + C + P VYT+V ++ WI
Sbjct: 192 MVCA-GAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIR 250
Query: 260 DVVRRS 265
+ ++R+
Sbjct: 251 ETMKRN 256
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 139 bits (351), Expect = 2e-33
Identities = 82/235 (34%), Positives = 116/235 (49%), Gaps = 11/235 (4%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHV 92
+I+GG+ +S PY S+ G H CGG L+ +WVVSA HC+ R V LG H
Sbjct: 23 KIVGGYNCEENSVPYQVSLN-SGYHFCGGSLINEQWVVSAGHCYKSRIQ----VRLGEHN 77
Query: 93 LSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPPT 152
+ E +Q + HP Y T NDI L++L+ AV+ V + LP PP
Sbjct: 78 IEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLP---TAPPA 134
Query: 153 AGTRCRVAGWG-FVSDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRR 211
GT+C ++GWG S + P L VL C +S+ G +T M C + +
Sbjct: 135 TGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKD 194
Query: 212 GFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSS 266
C DSGGP+VC + G+VS+ G C P VYT+V +V WI + + +S
Sbjct: 195 S-CQGDSGGPVVCNGQLQGVVSW-GDGCAQKNKPGVYTKVYNYVKWIKNTIAANS 247
>gi|11342670 azurocidin 1 preproprotein [Homo sapiens]
Length = 251
Score = 137 bits (346), Expect = 8e-33
Identities = 91/239 (38%), Positives = 131/239 (54%), Gaps = 16/239 (6%)
Query: 34 IIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHVL 93
I+GG + P P++AS++ G+H CGG L+ AR+V++AA CF ++ VVLGA+ L
Sbjct: 27 IVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDL 86
Query: 94 STAE-PTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPPT 152
E ++Q F I +++ + Y P + ND+ LL+L+ A L +V +L LP + A
Sbjct: 87 RRRERQSRQTFSISSMSEN-GYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNA-TVE 144
Query: 153 AGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDSHRRG 212
AGTRC+VAGWG L V V D C + + T + TR G G
Sbjct: 145 AGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQC----RPNNVCTGVLTRRG-----G 195
Query: 213 FCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVRRSSPQPGP 271
C+ D G PLVC AHG+ SFS CG + PD +T+V+ F WI V+ ++P PGP
Sbjct: 196 ICNGDGGTPLVCEGLAHGVASFSLGPCG--RGPDFFTRVALFRDWIDGVL--NNPGPGP 250
>gi|4503149 cathepsin G preproprotein [Homo sapiens]
Length = 255
Score = 137 bits (345), Expect = 1e-32
Identities = 97/249 (38%), Positives = 127/249 (51%), Gaps = 15/249 (6%)
Query: 19 LMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRF---GGQHHCGGFLLRARWVVSAAHC 75
L+L P G+ +IIGG E PHSRPYMA ++ GQ CGGFL+R +V++AAHC
Sbjct: 6 LLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHC 65
Query: 76 FSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLG 135
+ V LGAH + E TQQ HP Y+ T NDI LL+L+
Sbjct: 66 WGSNI----NVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRN 121
Query: 136 PAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGH 195
V + LP R GT C VAGWG VS L E ++RV C + +
Sbjct: 122 RNVNPVALP-RAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIFGSY 179
Query: 196 LTLTMLCTRSGD-SHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAF 254
+C GD R+ DSGGPL+C N AHG+VS+ G G P P+V+T+VS+F
Sbjct: 180 DPRRQICV--GDRRERKAAFKGDSGGPLLCNNVAHGIVSY-GKSSGVP--PEVFTRVSSF 234
Query: 255 VAWIWDVVR 263
+ WI +R
Sbjct: 235 LPWIRTTMR 243
>gi|5453676 granzyme A precursor [Homo sapiens]
Length = 262
Score = 137 bits (344), Expect = 1e-32
Identities = 83/226 (36%), Positives = 120/226 (53%), Gaps = 12/226 (5%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHV 92
+IIGG+EVTPHSRPYM + + C G L+ WV++AAHC + + V+LGAH
Sbjct: 28 KIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLN---KRSQVILGAHS 84
Query: 93 LSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRARPPT 152
++ EPT+Q+ + +P Y P T D+ LL+L A + V +L LP ++
Sbjct: 85 ITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLTEKAKINKYVTILHLP-KKGDDVK 143
Query: 153 AGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNS----SWKGHLTLTMLCTRSGDS 208
GT C+VAGWG + L E + ++D VCN ++ + + M+C S
Sbjct: 144 PGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNHYNFNPVIGMNMVCAGSLRG 203
Query: 209 HRRGFCSADSGGPLVCRNRAHGLVSFSGL--WCGDPKTPDVYTQVS 252
R C+ DSG PL+C G+ SF GL CGDP+ P VY +S
Sbjct: 204 GRDS-CNGDSGSPLLCEGVFRGVTSF-GLENKCGDPRGPGVYILLS 247
>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
Length = 305
Score = 136 bits (343), Expect = 2e-32
Identities = 86/248 (34%), Positives = 123/248 (49%), Gaps = 16/248 (6%)
Query: 22 PVKPPAGSWGAQ---IIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSH 78
P+ P AG AQ ++GGHE PHS+P+ A++ G Q CGG L+ WV++AAHC
Sbjct: 63 PLPPAAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKP 122
Query: 79 RDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPM---THANDICLLRLNGSAVLG 135
+ V LG H L + +Q + HP Y+ H +D+ LL+L A LG
Sbjct: 123 K----YTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLG 178
Query: 136 PAVGLLRLPGRRARPPTAGTRCRVAGWGFV-SDFEELPPGLMEAKVRVLDPDVCNSSWKG 194
V + L +P G +C V+GWG V S E P L A+V++ C ++ G
Sbjct: 179 SKVKPISLADHCTQP---GQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPG 235
Query: 195 HLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAF 254
+T M+C +G S C DSGGPLVC G+ S+ CG P VYT + +
Sbjct: 236 QITDGMVC--AGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRY 293
Query: 255 VAWIWDVV 262
+ WI ++
Sbjct: 294 LDWIKKII 301
>gi|4502907 chymase 1, mast cell preproprotein [Homo sapiens]
Length = 247
Score = 135 bits (341), Expect = 3e-32
Identities = 89/235 (37%), Positives = 121/235 (51%), Gaps = 14/235 (5%)
Query: 33 QIIGGHEVTPHSRPYMASVRF----GGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVL 88
+IIGG E PHSRPYMA + G CGGFL+R +V++AAHC R+ V L
Sbjct: 21 EIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAG----RSITVTL 76
Query: 89 GAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRA 148
GAH ++ E T Q + HP Y+ T +DI LL+L A L AVG L P +
Sbjct: 77 GAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFN 136
Query: 149 RPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDS 208
P G CRVAGWG + L E K+R++DP C S ++ LC +
Sbjct: 137 FVP-PGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQAC-SHFRDFDHNLQLCVGNPRK 194
Query: 209 HRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVR 263
+ F DSGGPL+C A G+VS+ D K P V+T++S + WI +++
Sbjct: 195 TKSAF-KGDSGGPLLCAGVAQGIVSYGR---SDAKPPAVFTRISHYRPWINQILQ 245
>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
Length = 247
Score = 135 bits (339), Expect = 5e-32
Identities = 87/256 (33%), Positives = 122/256 (47%), Gaps = 12/256 (4%)
Query: 12 LLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVS 71
LL + T + V P +I+GG+ +S PY S+ G H CGG L+ +WVVS
Sbjct: 3 LLLILTFVAAAVAAPFDD-DDKIVGGYICEENSVPYQVSLN-SGYHFCGGSLISEQWVVS 60
Query: 72 AAHCFSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGS 131
A HC+ R V LG H + E +Q + HP Y+ T NDI L++L+
Sbjct: 61 AGHCYKSRIQ----VRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSP 116
Query: 132 AVLGPAVGLLRLPGRRARPPTAGTRCRVAGWG-FVSDFEELPPGLMEAKVRVLDPDVCNS 190
AV+ V + LP PP AGT ++GWG +S + P L VL C +
Sbjct: 117 AVINSRVSAISLP---TAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEA 173
Query: 191 SWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQ 250
S+ G +T M C + + C DSGGP+V G+VS+ G C P VYT+
Sbjct: 174 SYPGKITNNMFCVGFLEGGKDS-CQGDSGGPVVSNGELQGIVSW-GYGCAQKNRPGVYTK 231
Query: 251 VSAFVAWIWDVVRRSS 266
V +V WI D + +S
Sbjct: 232 VYNYVDWIKDTIAANS 247
>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
sapiens]
Length = 254
Score = 135 bits (339), Expect = 5e-32
Identities = 87/262 (33%), Positives = 132/262 (50%), Gaps = 19/262 (7%)
Query: 7 GW--GRPLLTVATALMLPVKPPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLL 64
GW G +L VA +L+ +GS +QII G + +PHS+P+ A++ + C G L+
Sbjct: 9 GWFLGYLILGVAGSLV------SGSC-SQIINGEDCSPHSQPWQAALVMENELFCSGVLV 61
Query: 65 RARWVVSAAHCFSHRDLRTGLVVLGAHVLST-AEPTQQVFGIDALTTHPDYHPMTHANDI 123
+WV+SAAHCF + + + LG H L EP Q+ HP+Y+ AND+
Sbjct: 62 HPQWVLSAAHCFQN----SYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDL 117
Query: 124 CLLRLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVL 183
L++L+ S + + + ++ PTAG C V+GWG +++ +P L V V+
Sbjct: 118 MLIKLDESVSESDTIRSISIA---SQCPTAGNSCLVSGWGLLAN-GRMPTVLQCVNVSVV 173
Query: 184 DPDVCNSSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPK 243
+VC+ + +M C G + C+ DSGGPL+C GLVSF CG
Sbjct: 174 SEEVCSKLYDPLYHPSMFCAGGGHDQKDS-CNGDSGGPLICNGYLQGLVSFGKAPCGQVG 232
Query: 244 TPDVYTQVSAFVAWIWDVVRRS 265
P VYT + F WI V+ S
Sbjct: 233 VPGVYTNLCKFTEWIEKTVQAS 254
>gi|110815798 ovochymase 1 [Homo sapiens]
Length = 1134
Score = 134 bits (338), Expect = 7e-32
Identities = 89/298 (29%), Positives = 140/298 (46%), Gaps = 30/298 (10%)
Query: 11 PLLTVATAL--MLPVKPPAGSW-GAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRAR 67
P+ TV L + + P + W +I GG E PH P+ +RF G + CGG ++
Sbjct: 549 PVSTVKAILHDVCGIPPFSPQWLSRRIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPV 608
Query: 68 WVVSAAHCFS-HRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLL 126
W+++AAHC + + ++ G H + E T+QV + H D++ +++ +DI L+
Sbjct: 609 WILTAAHCVQLKNNPLSWTIIAGDHDRNLKESTEQVRRAKHIIVHEDFNTLSYDSDIALI 668
Query: 127 RLNGSAVLGPAVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPD 186
+L+ V + LP A P + C V GWG +S L L + +V VL+ +
Sbjct: 669 QLSSPLEYNSVVRPVCLP-HSAEPLFSSEICAVTGWGSISADGGLASRLQQIQVHVLERE 727
Query: 187 VCN----SSWKGHLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNR-----AHGLVSFSGL 237
VC S+ G +T M+C S + FC DSGGPLVCR+ +G+VS+ G
Sbjct: 728 VCEHTYYSAHPGGITEKMICAGFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSW-GA 786
Query: 238 WCGDPKTPDVYTQVSAFVAWIWD---------------VVRRSSPQPGPLPGTTRPPG 280
C P P V+ +V F+ WI +++ P P P P + PG
Sbjct: 787 GCVQPWKPGVFARVMIFLDWIQSKINGPASLQTNNKCKTLKQQLPPPTPSPDSASWPG 844
Score = 92.0 bits (227), Expect = 5e-19
Identities = 69/217 (31%), Positives = 99/217 (45%), Gaps = 18/217 (8%)
Query: 29 SWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHC---FSHRDLRTGL 85
SW + GH P+ S++ H CGG L++ VV+AAHC S + L+
Sbjct: 49 SWRNSTVTGH-------PWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNIT 101
Query: 86 VVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHAN-DICLLRLNGSAVLGPAVGLLRLP 144
V G + L + +Q + + THP+Y+ + + DI LL L G AV + LP
Sbjct: 102 VTSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLP 161
Query: 145 GRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKG----HLTLTM 200
+ G C +GWG +S E L E ++ ++D CN+ K L TM
Sbjct: 162 DSDDK-VEPGILCLSSGWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGRTM 220
Query: 201 LCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGL 237
LC D C DSGGPLVCR R G+ +G+
Sbjct: 221 LCAGFPD-WGMDACQGDSGGPLVCR-RGGGIWILAGI 255
>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
Length = 260
Score = 132 bits (332), Expect = 3e-31
Identities = 80/234 (34%), Positives = 117/234 (50%), Gaps = 13/234 (5%)
Query: 33 QIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAHV 92
+++GGHE PHS+P+ A++ G Q CGG L+ WV++AAHC + V LG H
Sbjct: 32 KVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPK----YTVRLGDHS 87
Query: 93 LSTAEPTQQVFGIDALTTHPDYHPM---THANDICLLRLNGSAVLGPAVGLLRLPGRRAR 149
L + +Q + HP Y+ H +D+ LL+L A LG V + L +
Sbjct: 88 LQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQ 147
Query: 150 PPTAGTRCRVAGWGFV-SDFEELPPGLMEAKVRVLDPDVCNSSWKGHLTLTMLCTRSGDS 208
P G +C V+GWG V S E P L A+V++ C ++ G +T M+C +G S
Sbjct: 148 P---GQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVC--AGSS 202
Query: 209 HRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVV 262
C DSGGPLVC G+ S+ CG P VYT + ++ WI ++
Sbjct: 203 KGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKII 256
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 132 bits (331), Expect = 4e-31
Identities = 90/244 (36%), Positives = 119/244 (48%), Gaps = 14/244 (5%)
Query: 32 AQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHC---FSHRDLRTGLVVL 88
++I+GG V P P+ ASV G +H CGG +L RWVV+AAHC F L + V
Sbjct: 216 SRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHA 275
Query: 89 GAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLGPAVGLLRLPGRRA 148
G S P Q ++ + HP Y H D+ LLRL + VG + LP +
Sbjct: 276 GLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQ 334
Query: 149 RPPTAGTRCRVAGWGFVSDFEELPPG-LMEAKVRVLDPDVCNSS--WKGHLTLTMLCTRS 205
P G+RC V+GWG L + V + +CNSS + G LT MLC
Sbjct: 335 HFP-KGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGY 393
Query: 206 GDSHRRGFCSADSGGPLVCRN----RAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDV 261
D R C DSGGPLVC + R G+VS+ G C +P P VY +V+ F+ WI D
Sbjct: 394 LDG-RADACQGDSGGPLVCPDGDTWRLVGVVSW-GRGCAEPNHPGVYAKVAEFLDWIHDT 451
Query: 262 VRRS 265
+ S
Sbjct: 452 AQDS 455
>gi|6679625 elastase 3B, pancreatic preproprotein [Homo sapiens]
Length = 270
Score = 129 bits (325), Expect = 2e-30
Identities = 91/254 (35%), Positives = 133/254 (52%), Gaps = 22/254 (8%)
Query: 25 PPAGSWGAQIIGGHEVTPHSRPYMASVRFGGQ----HHCGGFLLRARWVVSAAHCFSHRD 80
PP+ ++++ G + P+S P+ S+++ H CGG L+ WVV+A HC S
Sbjct: 20 PPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHCIS--S 77
Query: 81 LRTGLVVLGAHVLSTAEPTQQVFGIDA--LTTHPDYHPMTHA--NDICLLRLNGSAVLGP 136
RT VVLG + + E +QV I++ L HP ++ A NDI L++L+ SA LG
Sbjct: 78 SRTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGD 137
Query: 137 AVGLLRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCN--SSWKG 194
AV L LP P T C + GWG + LP L EA + V+D + C+ + W
Sbjct: 138 AVQLASLPPAGDILPNE-TPCYITGWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGS 196
Query: 195 HLTLTMLCTRSGDSHRRGFCSADSGGPLVCRN-----RAHGLVSF-SGLWCGDPKTPDVY 248
+ TM+C +G R G C+ DSGGPL C + HG+ SF S C + P V+
Sbjct: 197 SVKKTMVC--AGGDIRSG-CNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVF 253
Query: 249 TQVSAFVAWIWDVV 262
T+VSAF+ WI + +
Sbjct: 254 TRVSAFIDWIEETI 267
>gi|4502173 prostate specific antigen isoform 1 preproprotein [Homo
sapiens]
Length = 261
Score = 129 bits (324), Expect = 3e-30
Identities = 82/243 (33%), Positives = 118/243 (48%), Gaps = 20/243 (8%)
Query: 32 AQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVLGAH 91
++I+GG E HS+P+ V G+ CGG L+ +WV++AAHC ++ + ++LG H
Sbjct: 23 SRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSV----ILLGRH 78
Query: 92 VLSTAEPTQQVFGIDALTTHPDYHPMTHAN-----------DICLLRLNGSAVLGPAVGL 140
L E T QVF + HP Y N D+ LLRL+ A L AV +
Sbjct: 79 SLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKV 138
Query: 141 LRLPGRRARPPTAGTRCRVAGWGFVSDFEELPPGLMEA-KVRVLDPDVCNSSWKGHLTLT 199
+ LP + P GT C +GWG + E L P ++ + V+ DVC +T
Sbjct: 139 MDLP---TQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKF 195
Query: 200 MLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIW 259
MLC + CS DSGGPLVC G+ S+ C P+ P +YT+V + WI
Sbjct: 196 MLCAGRWTGGK-STCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIK 254
Query: 260 DVV 262
D +
Sbjct: 255 DTI 257
>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 127 bits (320), Expect = 8e-30
Identities = 81/249 (32%), Positives = 121/249 (48%), Gaps = 14/249 (5%)
Query: 19 LMLPVKPPAGSWGAQ---IIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHC 75
LM+ + A +W + ++ G S PY A++ G CGG L+ WV++AAHC
Sbjct: 4 LMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHC 63
Query: 76 FSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLG 135
+L+ V LG H L E +Q+ + HPDY +H DI LLRL A L
Sbjct: 64 -KKPNLQ---VFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLS 119
Query: 136 PAVGLLRLPGRRARPPTAGTR-CRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKG 194
+ L L R +A T C + GWG +D + P + A + ++ + C ++ G
Sbjct: 120 ELIQPLPLE----RDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREECEHAYPG 174
Query: 195 HLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAF 254
+T MLC + + + C DSGGPLVC + GLVS+ + CG + P VYT V +
Sbjct: 175 QITQNMLCA-GDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRY 233
Query: 255 VAWIWDVVR 263
WI ++
Sbjct: 234 TNWIQKTIQ 242
>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 127 bits (320), Expect = 8e-30
Identities = 81/249 (32%), Positives = 121/249 (48%), Gaps = 14/249 (5%)
Query: 19 LMLPVKPPAGSWGAQ---IIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHC 75
LM+ + A +W + ++ G S PY A++ G CGG L+ WV++AAHC
Sbjct: 4 LMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHC 63
Query: 76 FSHRDLRTGLVVLGAHVLSTAEPTQQVFGIDALTTHPDYHPMTHANDICLLRLNGSAVLG 135
+L+ V LG H L E +Q+ + HPDY +H DI LLRL A L
Sbjct: 64 -KKPNLQ---VFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLS 119
Query: 136 PAVGLLRLPGRRARPPTAGTR-CRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSSWKG 194
+ L L R +A T C + GWG +D + P + A + ++ + C ++ G
Sbjct: 120 ELIQPLPLE----RDCSANTTSCHILGWGKTAD-GDFPDTIQCAYIHLVSREECEHAYPG 174
Query: 195 HLTLTMLCTRSGDSHRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAF 254
+T MLC + + + C DSGGPLVC + GLVS+ + CG + P VYT V +
Sbjct: 175 QITQNMLCA-GDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRY 233
Query: 255 VAWIWDVVR 263
WI ++
Sbjct: 234 TNWIQKTIQ 242
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.470
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,930,988
Number of Sequences: 37866
Number of extensions: 707924
Number of successful extensions: 2740
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2128
Number of HSP's gapped (non-prelim): 200
length of query: 283
length of database: 18,247,518
effective HSP length: 101
effective length of query: 182
effective length of database: 14,423,052
effective search space: 2624995464
effective search space used: 2624995464
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.