Search of human proteins with 47519867

Search of human proteins with 47519867

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo
sapiens]
         (447 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   913   0.0  
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   691   0.0  
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...   374   e-103
gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [...   301   1e-81
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   284   1e-76
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   284   1e-76
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   267   1e-71
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   199   4e-51
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   162   4e-40
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    157   2e-38
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   155   7e-38
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   155   9e-38
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   154   2e-37
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   152   5e-37
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   152   5e-37
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   148   1e-35
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   145   9e-35
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   144   2e-34
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   137   2e-32
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     136   3e-32
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   132   6e-31
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   124   1e-28
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   123   3e-28
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   112   5e-25
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   106   4e-23
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              105   1e-22
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]   104   1e-22
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...    86   7e-17
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...    81   2e-15
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...    80   4e-15

>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  913 bits (2360), Expect = 0.0
 Identities = 447/447 (100%), Positives = 447/447 (100%)

Query: 1   MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNY 60
           MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNY
Sbjct: 1   MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNY 60

Query: 61  SIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENL 120
           SIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENL
Sbjct: 61  SIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENL 120

Query: 121 WLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180
           WLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF
Sbjct: 121 WLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180

Query: 181 SSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFY 240
           SSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFY
Sbjct: 181 SSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFY 240

Query: 241 VAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLL 300
           VAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLL
Sbjct: 241 VAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLL 300

Query: 301 PASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRC 360
           PASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRC
Sbjct: 301 PASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRC 360

Query: 361 CPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSH 420
           CPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSH
Sbjct: 361 CPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSH 420

Query: 421 AMDTLLFRLYLLFMASSILTVIVLWNT 447
           AMDTLLFRLYLLFMASSILTVIVLWNT
Sbjct: 421 AMDTLLFRLYLLFMASSILTVIVLWNT 447


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  691 bits (1782), Expect = 0.0
 Identities = 334/446 (74%), Positives = 376/446 (84%), Gaps = 9/446 (2%)

Query: 11  ALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISF 70
           ALL LT S+   GRG  FTINCSGF QHG DP    +VF+RK FRP TN S+PT+VNISF
Sbjct: 26  ALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISF 85

Query: 71  TLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVES 130
            +SAIL V+ QL LL+SFLW+++VWDNPFI+WNP+EC GI K+++ A+NLWLPDIFI+E 
Sbjct: 86  AMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIEL 145

Query: 131 MDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSM 190
           MDVD+TP GLTAY+S+EGRI+Y KPM+V SICNLDIFYFPFDQQNCT TFSSFLYTVDSM
Sbjct: 146 MDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSM 205

Query: 191 LLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLY 250
           LL M+KEVWEITD SR ++QT GEWELLG++KAT K+S G NLYDQI+FYVAIRRRPSLY
Sbjct: 206 LLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLY 265

Query: 251 IINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISV 310
           +INLLVPS FLVAIDALSFYLP +S NR PFKITLLLGYNVFLLMM+DLLP SGTPLI V
Sbjct: 266 VINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGV 325

Query: 311 YFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNK 370
           YFALCLSLMV SLLET+FIT+LLHVATTQPPP+PRWLHSLLLHC SPGRCCPTAPQK NK
Sbjct: 326 YFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENK 385

Query: 371 GLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQ---------LMELWVQFSHA 421
           G GLT THLPG KEP   AG+  GP E E  GGS WT+ Q          +ELW+QFSHA
Sbjct: 386 GPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHA 445

Query: 422 MDTLLFRLYLLFMASSILTVIVLWNT 447
           MD +LFRLYLLFMASSI+TVI LWNT
Sbjct: 446 MDAMLFRLYLLFMASSIITVICLWNT 471


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score =  374 bits (960), Expect = e-103
 Identities = 221/414 (53%), Positives = 259/414 (62%), Gaps = 56/414 (13%)

Query: 68  ISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFI 127
           + F L  +L  D+ LQL+TSFLW+++        WNP EC GI K  +  ENLWL D+FI
Sbjct: 13  LGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFI 63

Query: 128 VESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTV 187
            ES  VDQTP+GL A +S              S C            N T + S  +   
Sbjct: 64  EES--VDQTPAGLMASMSI-----VKATSNTISQCGWSA------SANWTPSISPSMDRG 110

Query: 188 DSMLLGMDK----EVWEITDTS-----RKVIQTQGEWELLGINKATPKMSMGNNLYDQIM 238
           +     +        W     S     R   +T+ EW LLGI K T K+++  N Y+Q +
Sbjct: 111 ERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAI 170

Query: 239 FYVAIRRR--PSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMM 296
           F+VAIRRR  PS Y++N LVPS  L+AIDALSFYLP ES N APFK+T+LLGY+VFLLMM
Sbjct: 171 FHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMM 230

Query: 297 NDLLPASGTPLIS--------------VYFALCLSLMVVSLLETVFITYLLHVATTQPPP 342
           NDLLPA+ T   +              VYFALCLSLMV SLLET+FIT+LLHVATTQP P
Sbjct: 231 NDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLP 290

Query: 343 MPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDG 402
           +PRWLHSLLLHCT  GRCCPTAPQKGNKG GLT THLPG KEP   AG+  GP E E  G
Sbjct: 291 LPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTG 350

Query: 403 GSGWTKTQ---------LMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT 447
           GS WT+ Q          +ELWVQFSHAMD LLFRLYLLFMASSI+TVI LWNT
Sbjct: 351 GSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 404


>gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2
           [Homo sapiens]
          Length = 279

 Score =  301 bits (770), Expect = 1e-81
 Identities = 160/232 (68%), Positives = 175/232 (75%), Gaps = 25/232 (10%)

Query: 241 VAIRRR--PSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMND 298
           VAIRRR  PS Y++N LVPS  L+AIDALSFYLP ES N APFK+T+LLGY+VFLLMMND
Sbjct: 48  VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107

Query: 299 LLPASGTPLIS--------------VYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344
           LLPA+ T   +              VYFALCLSLMV SLLET+FIT+LLHVATTQP P+P
Sbjct: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167

Query: 345 RWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGS 404
           RWLHSLLLHCT  GRCCPTAPQKGNKG GLT THLPG KEP   AG+  GP E E  GGS
Sbjct: 168 RWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGS 227

Query: 405 GWTKTQ---------LMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT 447
            WT+ Q          +ELWVQFSHAMD LLFRLYLLFMASSI+TVI LWNT
Sbjct: 228 EWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 279


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  284 bits (726), Expect = 1e-76
 Identities = 161/433 (37%), Positives = 252/433 (58%), Gaps = 42/433 (9%)

Query: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110
           RK  RP  ++  PT V+I   + AIL VD + Q+LT+++W    W + F+ WNP++   I
Sbjct: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111

Query: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFP 170
            KL++  +++W+PDI I E +DV ++P+    YI  +G ++  KP++V + C+LDI+ FP
Sbjct: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171

Query: 171 FDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITD---TSRKVIQTQGEWELLGINKATPKM 227
           FD QNC+ TF+S+L+T+  + + +    W + +   + R V   QGEWELLG+     + 
Sbjct: 172 FDVQNCSLTFTSWLHTIQDINISL----WRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227

Query: 228 SM-GNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286
           SM  +N Y ++ FYV IRRRP  Y+++LL+PS FL+ +D + FYLP  S  R  FKITLL
Sbjct: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287

Query: 287 LGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344
           LGY+VFL++++D LPA+  GTPLI VYF +C++L+V+SL ET+FI  L+H    Q  P+P
Sbjct: 288 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QPVP 346

Query: 345 RWLHSLLLHCTSPGRCC--------PTAPQKGNK-----GLGLTLTHLPGP----KEPGE 387
            WL  L+L   +   C         P A  +  K      +G   +H+ GP    K P +
Sbjct: 347 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 406

Query: 388 LAGKKLGPRET---------EPDGGSGW--TKTQLMEL---WVQFSHAMDTLLFRLYLLF 433
                  PRE          E      +   + ++ E+   W++    +D LLF +YLL 
Sbjct: 407 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 466

Query: 434 MASSILTVIVLWN 446
           + +  +T+++LW+
Sbjct: 467 VLAYSITLVMLWS 479


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  284 bits (726), Expect = 1e-76
 Identities = 161/433 (37%), Positives = 252/433 (58%), Gaps = 42/433 (9%)

Query: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110
           RK  RP  ++  PT V+I   + AIL VD + Q+LT+++W    W + F+ WNP++   I
Sbjct: 31  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 90

Query: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFP 170
            KL++  +++W+PDI I E +DV ++P+    YI  +G ++  KP++V + C+LDI+ FP
Sbjct: 91  TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 150

Query: 171 FDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITD---TSRKVIQTQGEWELLGINKATPKM 227
           FD QNC+ TF+S+L+T+  + + +    W + +   + R V   QGEWELLG+     + 
Sbjct: 151 FDVQNCSLTFTSWLHTIQDINISL----WRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 206

Query: 228 SM-GNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286
           SM  +N Y ++ FYV IRRRP  Y+++LL+PS FL+ +D + FYLP  S  R  FKITLL
Sbjct: 207 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 266

Query: 287 LGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344
           LGY+VFL++++D LPA+  GTPLI VYF +C++L+V+SL ET+FI  L+H    Q  P+P
Sbjct: 267 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QPVP 325

Query: 345 RWLHSLLLHCTSPGRCC--------PTAPQKGNK-----GLGLTLTHLPGP----KEPGE 387
            WL  L+L   +   C         P A  +  K      +G   +H+ GP    K P +
Sbjct: 326 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 385

Query: 388 LAGKKLGPRET---------EPDGGSGW--TKTQLMEL---WVQFSHAMDTLLFRLYLLF 433
                  PRE          E      +   + ++ E+   W++    +D LLF +YLL 
Sbjct: 386 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 445

Query: 434 MASSILTVIVLWN 446
           + +  +T+++LW+
Sbjct: 446 VLAYSITLVMLWS 458


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  267 bits (683), Expect = 1e-71
 Identities = 161/465 (34%), Positives = 252/465 (54%), Gaps = 74/465 (15%)

Query: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110
           RK  RP  ++  PT V+I   + AIL VD + Q+LT+++W    W + F+ WNP++   I
Sbjct: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111

Query: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFP 170
            KL++  +++W+PDI I E +DV ++P+    YI  +G ++  KP++V + C+LDI+ FP
Sbjct: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171

Query: 171 FDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITD---TSRKVIQTQGEWELLGINKATPKM 227
           FD QNC+ TF+S+L+T+  + + +    W + +   + R V   QGEWELLG+     + 
Sbjct: 172 FDVQNCSLTFTSWLHTIQDINISL----WRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227

Query: 228 SM-GNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286
           SM  +N Y ++ FYV IRRRP  Y+++LL+PS FL+ +D + FYLP  S  R  FKITLL
Sbjct: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287

Query: 287 LGYNVFLLMMNDLLPAS--GTPLI--------------------------------SVYF 312
           LGY+VFL++++D LPA+  GTPLI                                 VYF
Sbjct: 288 LGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYF 347

Query: 313 ALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCC--------PTA 364
            +C++L+V+SL ET+FI  L+H    Q  P+P WL  L+L   +   C         P A
Sbjct: 348 VVCMALLVISLAETIFIVRLVHKQDLQ-QPVPAWLRHLVLERIAWLLCLREQSTSQRPPA 406

Query: 365 PQKGNK-----GLGLTLTHLPGP----KEPGELAGKKLGPRET---------EPDGGSGW 406
             +  K      +G   +H+ GP    K P +       PRE          E      +
Sbjct: 407 TSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQF 466

Query: 407 --TKTQLMEL---WVQFSHAMDTLLFRLYLLFMASSILTVIVLWN 446
              + ++ E+   W++    +D LLF +YLL + +  +T+++LW+
Sbjct: 467 LEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  199 bits (506), Expect = 4e-51
 Identities = 102/285 (35%), Positives = 167/285 (58%), Gaps = 3/285 (1%)

Query: 52  KAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGIN 111
           K  RP  N++  T V +   + AIL VDA+ Q+L + +W   VW++ F++WN      I 
Sbjct: 45  KEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIR 104

Query: 112 KLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPF 171
           ++++    +W PDI I E +D+++ P     Y++S G I+  KP++V S C+L+ + FPF
Sbjct: 105 EISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPF 164

Query: 172 DQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGN 231
           D QNC+ TF S L+TV+ + L   +   +I    +K      EWELL ++     +    
Sbjct: 165 DVQNCSLTFKSILHTVEDVDLAFLRSPEDI-QHDKKAFLNDSEWELLSVSSTYSILQSSA 223

Query: 232 NLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNV 291
             + QI F V +RR P +Y+++LL+PS FL+ +D  SFYLP     R  FK ++L+GY V
Sbjct: 224 GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTV 283

Query: 292 FLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLH 334
           F + M++ +P S   TPLI  +F +C++ +V+SL +++ +   LH
Sbjct: 284 FRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  162 bits (411), Expect = 4e-40
 Identities = 90/304 (29%), Positives = 157/304 (51%), Gaps = 10/304 (3%)

Query: 53  AFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINK 112
           A RP  +      V +  TLS I  +D + Q+LT++LW+  +W + ++ W+  +  G++ 
Sbjct: 45  ALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDS 104

Query: 113 LTVLAENLWLPDIFIVESMDVDQT-PSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPF 171
           + + ++ +W PDI +    D + + P      +  +G I +D P    S C +D+ YFPF
Sbjct: 105 IRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPF 164

Query: 172 DQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMG- 230
           D Q C  TF S+ Y  + + +    +  +++D    V     EWE+ G+      +S G 
Sbjct: 165 DNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDV-----EWEVHGMPAVKNVISYGC 219

Query: 231 -NNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGY 289
            +  Y  + F + ++RR S YI+NLL+P   +  +  LSFYLPA S  +    +T+LL  
Sbjct: 220 CSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAM 279

Query: 290 NVFLLMMNDLLPAS-GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLH 348
            VF LM+ +++PAS   PLI  Y+   ++L+  S   T+ +   +H    +  P+P W  
Sbjct: 280 TVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMN-IHFCGAEARPVPHWAR 338

Query: 349 SLLL 352
            ++L
Sbjct: 339 VVIL 342


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  157 bits (397), Expect = 2e-38
 Identities = 92/306 (30%), Positives = 155/306 (50%), Gaps = 17/306 (5%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP  N S P  V+    ++ +  VD   Q++ + LW+  +W++  + W+P E  GI  L 
Sbjct: 50  RPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLR 109

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           V A+ +W PDI +  +   D    G T A +   G I +  P    S C +DI +FPFD 
Sbjct: 110 VPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDH 169

Query: 174 QNCTFTFSSFLYT---VDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGIN--KATPKMS 228
           QNC+  F S+ Y    +D +++G   ++ +  + S        EWE++  +  K   K +
Sbjct: 170 QNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENS--------EWEIIDASGYKHDIKYN 221

Query: 229 MGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLG 288
               +Y  I +   IRR P  Y INL++P  F+  +  L FYLP++   +    I++LL 
Sbjct: 222 CCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLS 281

Query: 289 YNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRW 346
             VFLL++ + +P++    PL+  Y    +  + +S++ TVF+   +H  T     MPRW
Sbjct: 282 LTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLN-IHYRTPTTHTMPRW 340

Query: 347 LHSLLL 352
           + ++ L
Sbjct: 341 VKTVFL 346


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  155 bits (392), Expect = 7e-38
 Identities = 91/308 (29%), Positives = 155/308 (50%), Gaps = 14/308 (4%)

Query: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110
           +K  RP  + +   +V     +S ++ VD + QL+T+ +W+   W +  + WNP +  GI
Sbjct: 41  QKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGI 100

Query: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYF 169
           + + V +E+LWLPDI + E+ D     S +T   + S G + +  P    S C +D+ +F
Sbjct: 101 HSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFF 160

Query: 170 PFDQQNCTFTFSSFLY---TVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPK 226
           PFD+QNC+  F S+ Y    VD +L+          +  RK     GEWE+L        
Sbjct: 161 PFDRQNCSMKFGSWTYDGTMVDLILIN--------ENVDRKDFFDNGEWEILNAKGMKGN 212

Query: 227 MSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286
              G   Y  I +   +RR P  Y + L++P   L  +  L FYLP++   +     ++L
Sbjct: 213 RRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVL 272

Query: 287 LGYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344
           +   VFLL++ +++P+S    PLI  Y    +  + +S++ TVF+  + H +++   PM 
Sbjct: 273 VSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMA 332

Query: 345 RWLHSLLL 352
            W+  L L
Sbjct: 333 PWVKRLFL 340


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  155 bits (391), Expect = 9e-38
 Identities = 97/347 (27%), Positives = 163/347 (46%), Gaps = 12/347 (3%)

Query: 53  AFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINK 112
           A RP  +      V +  TLS I+ +D + Q+LT +LW+   W + ++ W+P    G++ 
Sbjct: 44  ALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDA 103

Query: 113 LTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPF 171
           + + +  +W PDI +    D     S  T   +  +G +++D P    S C +D+  FPF
Sbjct: 104 IRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPF 163

Query: 172 DQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMG- 230
           D Q+C  TF S+ +    + +        + D    V     EW +LG+      ++ G 
Sbjct: 164 DAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENV-----EWRVLGMPARRRVLTYGC 218

Query: 231 -NNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGY 289
            +  Y  + F + +RRR + Y+ NLL+P   +  +  L+F+LPA+S  +    +T+LL  
Sbjct: 219 CSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLAL 278

Query: 290 NVF-LLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLH 348
            VF LL+   + PA   PLI  Y+   ++++  S   T+ I  L H       P+P W  
Sbjct: 279 TVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNL-HYCGPSVRPVPAWAR 337

Query: 349 SLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGP 395
           +LLL   + G C     +   +     L+  P P+ P   AG   GP
Sbjct: 338 ALLLGHLARGLCVRERGEPCGQSRPPELS--PSPQSPEGGAGPPAGP 382


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  154 bits (388), Expect = 2e-37
 Identities = 93/323 (28%), Positives = 160/323 (49%), Gaps = 25/323 (7%)

Query: 44  VFQAVFD--RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFIN 101
           +F+ +F+   +  RP  N S P  ++   ++S ++ VD   Q++ + LW+  +W++  + 
Sbjct: 38  LFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLK 97

Query: 102 WNPKECVGINKLTVLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTS 160
           WNP +  G   + V A+ +W PDI +  +   D Q      A +   G + +  P    S
Sbjct: 98  WNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKS 157

Query: 161 ICNLDIFYFPFDQQNCTFTFSSFLYT---VDSMLLGMD---KEVWEITDTSRKVIQTQGE 214
            C +D+ YFPFD QNCT  F S+ Y    +D +L+G     K+ WE            GE
Sbjct: 158 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWE-----------SGE 206

Query: 215 WELLGIN--KATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLP 272
           W ++     K   K +    +Y  I + + IRR P  Y INL++P   +  +  L FYLP
Sbjct: 207 WAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLP 266

Query: 273 AESENRAPFKITLLLGYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFIT 330
           ++   +    I++LL   VFLL++ + +P++    PLI  Y    +  + +S++ TVF+ 
Sbjct: 267 SDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 326

Query: 331 YLLHVATTQPPPMPRWLHSLLLH 353
             +H  T     MP W+ ++ L+
Sbjct: 327 N-VHYRTPTTHTMPSWVKTVFLN 348


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  152 bits (385), Expect = 5e-37
 Identities = 88/307 (28%), Positives = 156/307 (50%), Gaps = 19/307 (6%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP  N S    V    +++ ++ VD + Q++T+ +W+   W +  + W+P +   +  + 
Sbjct: 53  RPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIR 112

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           + +E +W PDI +  + D D   + LT A++  +GR+++  P    S C++D+ +FPFDQ
Sbjct: 113 IPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQ 172

Query: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQ----GEWELLGI--NKATPKM 227
           QNCT  F S+ Y         DK   ++ +   +V Q      GEW ++       T K 
Sbjct: 173 QNCTMKFGSWTY---------DKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKY 223

Query: 228 SMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLL 287
                +Y  I +   IRR P  Y INL++P   +  +  L FYLP+E   +    I++LL
Sbjct: 224 ECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLL 283

Query: 288 GYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPR 345
              VFLL++ +++P++    PLI  Y    +  + +S++ TVF+   +H  + +   MP 
Sbjct: 284 SLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPRTHTMPT 342

Query: 346 WLHSLLL 352
           W+  + L
Sbjct: 343 WVRRVFL 349


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  152 bits (385), Expect = 5e-37
 Identities = 86/305 (28%), Positives = 153/305 (50%), Gaps = 11/305 (3%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP  N S    V    +++ ++ VD + Q++T+ +W+   W +  + WNP +   I  L 
Sbjct: 75  RPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLR 134

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           V +E +W+PDI +  + D +   + +T A++ S G + +  P    S C++D+ +FPFDQ
Sbjct: 135 VPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQ 194

Query: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKA--TPKMSMGN 231
           QNC   F S+ Y    + L   ++  ++ D         GEW ++       + K     
Sbjct: 195 QNCKMKFGSWTYDKAKIDLEQMEQTVDLKD-----YWESGEWAIVNATGTYNSKKYDCCA 249

Query: 232 NLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNV 291
            +Y  + +   IRR P  Y INL++P   +  +  L FYLP++   +    I++LL   V
Sbjct: 250 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 309

Query: 292 FLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHS 349
           FLL++ +++P++    PLI  Y    +  + +S++ TVF+   +H  +     MP W+  
Sbjct: 310 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPSTHTMPHWVRG 368

Query: 350 LLLHC 354
            LL C
Sbjct: 369 ALLGC 373


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  148 bits (373), Expect = 1e-35
 Identities = 97/304 (31%), Positives = 154/304 (50%), Gaps = 13/304 (4%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP  N S P  V  S +L  I+ VD + Q+LT+ +W+ + W + ++ WN  E  G+  + 
Sbjct: 42  RPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVR 101

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
                +W PDI +  S D     +  T   ++S G  +Y  P    S C +D+ +FPFD 
Sbjct: 102 FPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDV 161

Query: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGI--NKATPKMSMGN 231
           Q+C   F S+ Y   S+ L M +      D S  +    GEW+L+GI   ++        
Sbjct: 162 QHCKLKFGSWSYGGWSLDLQMQE-----ADISGYI--PNGEWDLVGIPGKRSERFYECCK 214

Query: 232 NLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNV 291
             Y  + F V +RRR   Y +NLL+P   + A+  L F LPA+S  +    IT+LL   V
Sbjct: 215 EPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTV 274

Query: 292 FLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHS 349
           F+L++ +++PA+    PLI+ YFA  + ++ +S++ TV I    H        MP+W   
Sbjct: 275 FMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV-IVLQYHHHDPDGGKMPKWTRV 333

Query: 350 LLLH 353
           +LL+
Sbjct: 334 ILLN 337


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  145 bits (365), Expect = 9e-35
 Identities = 86/319 (26%), Positives = 164/319 (51%), Gaps = 15/319 (4%)

Query: 37  QHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWD 96
           +H +DP+ +      K  RP TN S    V +  +L+ ++ V  + Q++T+ +W+   W+
Sbjct: 34  EHLLDPSRYN-----KLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWE 88

Query: 97  NPFINWNPKECVGINKLTVLAENLWLPDIFIVESMD-VDQTPSGLTAYISSEGRIKYDKP 155
           +  + W P+E   + K+ + ++++WLPD+ +  + D + +      A +S +G I +  P
Sbjct: 89  DYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPP 148

Query: 156 MRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEW 215
               S C +++ +FPFDQQNCT  F S+ Y    + L +  EV  + D         GEW
Sbjct: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDD-----FTPSGEW 203

Query: 216 ELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES 275
           +++ +       +  ++ Y  I +   IRR+P  Y INL++P   + ++  L FYLP++ 
Sbjct: 204 DIVAL-PGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262

Query: 276 ENRAPFKITLLLGYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLL 333
             +    I++LL   VFLL+++ ++P +    PL+  Y    + L+  S++ +V +  + 
Sbjct: 263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322

Query: 334 HVATTQPPPMPRWLHSLLL 352
           H + T     P W+  + L
Sbjct: 323 HRSPTTHTMAP-WVKVVFL 340


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  144 bits (363), Expect = 2e-34
 Identities = 81/311 (26%), Positives = 155/311 (49%), Gaps = 13/311 (4%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP        RV++   L+ ++ ++ + + +++ +++DL W +  ++W+P E  GI+ L 
Sbjct: 43  RPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLR 102

Query: 115 VLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           + AE++WLPD+ ++ + D +      ++  +SS+G +++  P    S C++ + YFPFD 
Sbjct: 103 ITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDW 162

Query: 174 QNCTFTFSSFLYTVDSMLL----GMDKEVWEITDTSRKVIQTQGEWELLG-----INKAT 224
           QNCT  FSS+ Y    + L    G D +  +            G+WE++      I    
Sbjct: 163 QNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPG 222

Query: 225 PKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKIT 284
                      +++FY+ IRR+P  Y++N++ P   +  +    FYLP ++  +    I 
Sbjct: 223 DPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIF 282

Query: 285 LLLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPP 342
            LL   VFLL++ D +P +    P+I  Y    + L+  S++ +V +   LH  +     
Sbjct: 283 ALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSV-VVLNLHHRSPHTHQ 341

Query: 343 MPRWLHSLLLH 353
           MP W+  + +H
Sbjct: 342 MPLWVRQIFIH 352


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  137 bits (346), Expect = 2e-32
 Identities = 78/309 (25%), Positives = 147/309 (47%), Gaps = 8/309 (2%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP  + +   ++     +S ++ VD + QL+T+ +W+   W +  + WNP +  GI  + 
Sbjct: 63  RPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIR 122

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQ 174
           V ++++W PDI + ++ D     +     I   G + +  P    S C +D+ +FPFD Q
Sbjct: 123 VPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQ 182

Query: 175 NCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLY 234
           NC+  F S+ Y    + +     + E  D  ++     GEWE++    +    +     Y
Sbjct: 183 NCSMKFGSWTYDGSQVDI-----ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWY 237

Query: 235 DQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLL 294
             + +   I+R P  Y + L++P   L  +  L FYLP+    +     ++L+   VFLL
Sbjct: 238 PYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLL 297

Query: 295 MMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLL 352
           ++ +++P+S    PLI  Y    +  + +S++ TVF   + H +++    M   +  + L
Sbjct: 298 VIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFL 357

Query: 353 HCTSPGRCC 361
           H T P   C
Sbjct: 358 H-TLPKLLC 365


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  136 bits (343), Expect = 3e-32
 Identities = 90/352 (25%), Positives = 171/352 (48%), Gaps = 20/352 (5%)

Query: 8   RQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVN 67
           R++  L L   + L GRG+    N    ++  +D  + +  ++    RP T+ S    + 
Sbjct: 2   RRAPSLVLFFLVALCGRGNCRVANA---EEKLMDDLLNKTRYNN-LIRPATSSSQLISIK 57

Query: 68  ISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFI 127
           +  +L+ ++ V+ + Q++T+ +W+   W +  + WN     G+N L + A+ +WLPDI +
Sbjct: 58  LQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVL 117

Query: 128 VESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLY- 185
             + D     S  T   + S G + +  P    S C +++ YFPFDQQNCT  F S+ Y 
Sbjct: 118 YNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYD 177

Query: 186 --TVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAI 243
              +D +L+     + + T +        GEW+++ +      ++  +  Y  + +   I
Sbjct: 178 HTEIDMVLMTPTASMDDFTPS--------GEWDIVAL-PGRRTVNPQDPSYVDVTYDFII 228

Query: 244 RRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPAS 303
           +R+P  Y INL++P      +  L FYLP++   +    I++LL    FLL+++ ++P +
Sbjct: 229 KRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPT 288

Query: 304 G--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLH 353
               PLI  Y    + L+  S++ +V +  + H + +     P W+    LH
Sbjct: 289 SLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAP-WVKRCFLH 339


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  132 bits (332), Expect = 6e-31
 Identities = 93/342 (27%), Positives = 160/342 (46%), Gaps = 25/342 (7%)

Query: 44  VFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWN 103
           +FQ     K  RP  +      V ++ TLS ++ +    + LT+ +W++  W +  + WN
Sbjct: 32  LFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWN 91

Query: 104 PKECVGINKLTVLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSIC 162
            +E   I+ L +  + +WLP+I +  + D   Q        +   G + +  P    S C
Sbjct: 92  AEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSC 151

Query: 163 NLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEV---------WEITDTSRKVIQTQG 213
            + + YFPFD QNC+  FSS  YT   + L + ++          W I D         G
Sbjct: 152 PISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG--FTENG 209

Query: 214 EWELLG----INKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSF 269
           EWE++     +N   P+  + +     I FY+ IRR+P  YIIN+LVP   +  +  L F
Sbjct: 210 EWEIVHRPARVN-VDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVF 268

Query: 270 YLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFI 329
           YLPA+S  +    I++LL  +VFLL+++  LPA+   +  +   L   +++V+++  + +
Sbjct: 269 YLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICV 328

Query: 330 TYL-LHVATTQPPPMPRWLHSL-------LLHCTSPGRCCPT 363
             L +H  T     +   +  L       LLH + P    P+
Sbjct: 329 IVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAEDGPS 370


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  124 bits (312), Expect = 1e-28
 Identities = 81/299 (27%), Positives = 150/299 (50%), Gaps = 19/299 (6%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP    S    V++  TL+ ++ ++ + + LT+ +W+++ W +  + W+P++  G+  L 
Sbjct: 42  RPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLR 101

Query: 115 VLAENLWLPDIFIVESMD-VDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           V +  +W PDI +  ++D V +        +S +G I +  P    S C++ + YFPFD 
Sbjct: 102 VPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDW 161

Query: 174 QNCTFTFSSFLYT---VDSMLLGMDKEVWEITDTSRKVIQTQGEWEL------LGINKAT 224
           QNC+  F S  Y+   +D  L   D +  E      +     GEW +      + ++ A 
Sbjct: 162 QNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAA 221

Query: 225 PKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES-ENRAPFKI 283
           P    G   + +++FY+ I+R+P  Y+IN++ P   + ++  L  +LPA++   +    I
Sbjct: 222 PAQEAG---HQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAI 278

Query: 284 TLLLGYNVFLLMMNDLLP--ASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQP 340
            +LL   VFL ++   +P  +   PLIS Y      L+VV++L  V    +L+V+   P
Sbjct: 279 NVLLAQTVFLFLVAKKVPETSQAVPLISKYLTF---LLVVTILIVVNAVVVLNVSLRSP 334


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  123 bits (309), Expect = 3e-28
 Identities = 74/304 (24%), Positives = 142/304 (46%), Gaps = 12/304 (3%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP  ++     V +   L  ++ VD   Q++T+ + +   W +  + WNP +  G+ K+ 
Sbjct: 40  RPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIH 99

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           + +E +W PD+ +  + D D      T   +   G I +  P    S C + + +FPFD+
Sbjct: 100 IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDE 159

Query: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEW---ELLGINKATPKMSMG 230
           QNC+    ++ Y    + +  + +  ++++         GEW   E  G   +       
Sbjct: 160 QNCSMKLGTWTYDGSVVAINPESDQPDLSN-----FMESGEWVIKESRGWKHSVTYSCCP 214

Query: 231 NNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYN 290
           +  Y  I ++  ++R P  +I+N+++P      +  L FYLP +S  +    I++LL   
Sbjct: 215 DTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLT 274

Query: 291 VFLLMMNDLLP--ASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLH 348
           VFLL++ +L+P  +S  PLI  Y    +  ++ S++ TV I    H  +     MP W+ 
Sbjct: 275 VFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITV-IVINTHHRSPSTHVMPNWVR 333

Query: 349 SLLL 352
            + +
Sbjct: 334 KVFI 337


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  112 bits (281), Expect = 5e-25
 Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 12/264 (4%)

Query: 95  WDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYD 153
           W +  + WNP +  G+ K+ + +E +W PD+ +  + D D      T   +   G I + 
Sbjct: 105 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWT 164

Query: 154 KPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQG 213
            P    S C + + +FPFD+QNC+    ++ Y    + +  + +  ++++         G
Sbjct: 165 PPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSN-----FMESG 219

Query: 214 EW---ELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFY 270
           EW   E  G   +       +  Y  I ++  ++R P  +I+N+++P      +  L FY
Sbjct: 220 EWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFY 279

Query: 271 LPAESENRAPFKITLLLGYNVFLLMMNDLLP--ASGTPLISVYFALCLSLMVVSLLETVF 328
           LP +S  +    I++LL   VFLL++ +L+P  +S  PLI  Y    +  ++ S++ TV 
Sbjct: 280 LPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITV- 338

Query: 329 ITYLLHVATTQPPPMPRWLHSLLL 352
           I    H  +     MP W+  + +
Sbjct: 339 IVINTHHRSPSTHVMPNWVRKVFI 362


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  106 bits (265), Expect = 4e-23
 Identities = 69/308 (22%), Positives = 141/308 (45%), Gaps = 11/308 (3%)

Query: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114
           RP         +++  TL+ ++ ++ + + LT+ +W+ + W +  +N++  +  GI  L 
Sbjct: 40  RPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLR 99

Query: 115 VLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173
           V +E +WLP+I +  ++D            +   G + +  P    S+C +++ YFPFD 
Sbjct: 100 VPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDW 159

Query: 174 QNCTFTFSSFLYTVD----SMLLGMDKEVWEITDTSRKVIQTQGEWEL---LGINKATPK 226
           QNC+  F S  Y  +    +  +  D +     D   +     GEW +    G+ +    
Sbjct: 160 QNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHG 219

Query: 227 MSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES-ENRAPFKITL 285
            +        +++ + IRR+P  Y+IN++VP   +  +  L+++LPA++   +    I +
Sbjct: 220 GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279

Query: 286 LLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPM 343
           LL   VFL ++   +P +    PL+  +    + +  + ++  V +  +     T     
Sbjct: 280 LLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMS 339

Query: 344 PRWLHSLL 351
           PR  H LL
Sbjct: 340 PRLRHVLL 347


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  105 bits (261), Expect = 1e-22
 Identities = 75/243 (30%), Positives = 121/243 (49%), Gaps = 13/243 (5%)

Query: 115 VLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQ 174
           +L ++LW+     +     D T       ++S G  +Y  P    S C +D+ +FPFD Q
Sbjct: 14  LLIQHLWIAANCDIADERFDAT-FHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQ 72

Query: 175 NCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGI--NKATPKMSMGNN 232
           +C   F S+ Y   S+ L M +      D S  +    GEW+L+GI   ++         
Sbjct: 73  HCKLKFGSWSYGGWSLDLQMQE-----ADISGYI--PNGEWDLVGIPGKRSERFYECCKE 125

Query: 233 LYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVF 292
            Y  + F V +RRR   Y +NLL+P   + A+  L F LPA+S  +    IT+LL   VF
Sbjct: 126 PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF 185

Query: 293 LLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSL 350
           +L++ +++PA+    PLI+ YFA  + ++ +S++ TV I    H        MP+W   +
Sbjct: 186 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV-IVLQYHHHDPDGGKMPKWTRVI 244

Query: 351 LLH 353
           LL+
Sbjct: 245 LLN 247


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score =  104 bits (260), Expect = 1e-22
 Identities = 93/379 (24%), Positives = 165/379 (43%), Gaps = 38/379 (10%)

Query: 5   WPARQSALLCLTVSLLLQGRGDAFTINCSGFD-QHGVDPAVFQAVFDRKAFRPF---TNY 60
           W       L  +++LLL        ++  GF     + P++F     +K         N 
Sbjct: 5   WSLLHLTFLGFSITLLL--------VHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNG 56

Query: 61  SIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENL 120
           S P  V++   +S +  VD     ++S L + L W +  + WN       + +T+  E+L
Sbjct: 57  SAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESL 115

Query: 121 WLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180
           W P + I+E++ VD       A +  +G +K +  +   + CN ++ +FP D  NC+ +F
Sbjct: 116 WTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF 175

Query: 181 SSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFY 240
               Y + +  + ++ +   + +    ++  + E+ +  +    P   +         F 
Sbjct: 176 ----YALSNTAMELEFQAHVVNE----IVSVKREYVVYDLKTQVPPQQL------VPCFQ 221

Query: 241 VAIRRRPSLY--IINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMND 298
           V +R + +    II LLVP+  L+  D     LP  +  R  +K+TLLL Y V    +  
Sbjct: 222 VTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQ 281

Query: 299 LLPASGT--PLISVYFALCLSLMVVSLLETVFITYLLH----VATTQPPPMPRWLHSLLL 352
            LP+S +  PL+  YF + L L+ +S +ETV +  LL      A + P P PR       
Sbjct: 282 ALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQR--- 338

Query: 353 HCTSPGRCCPTAPQKGNKG 371
              +PG      P +G KG
Sbjct: 339 EHGNPGPHPAEEPSRGVKG 357


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 71/310 (22%), Positives = 130/310 (41%), Gaps = 10/310 (3%)

Query: 31  NCSGFDQHGVDPAVFQAVFDRKAFRPFTNYS-IPTRVNISFTLSAILGVDAQLQLLTSFL 89
           NC       V   +   V  R   R   N+   P  V IS  +++I  +       T  +
Sbjct: 49  NCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITM 108

Query: 90  WMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDV---DQTPSGLTAYISS 146
           +    W +  + +  +  + +     + E LW+PD + + S D    D T       +  
Sbjct: 109 FFHQTWKDSRLAYY-ETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHP 167

Query: 147 EGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSR 206
           +G ++Y   +  T+ C+LD+  FP D+Q C     S+ YTV+ ++L  D     I  T  
Sbjct: 168 DGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEE 227

Query: 207 KVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDA 266
             I    ++  LG    + ++      Y +++    ++R  + Y++ +  P+        
Sbjct: 228 LHIP---QFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSW 284

Query: 267 LSFYLPAESE-NRAPFKITLLLGYNVFLLMMNDLLP-ASGTPLISVYFALCLSLMVVSLL 324
           +SF++  +S   R    +T +L        + D LP  S    I +Y  +CL  + +SLL
Sbjct: 285 ISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLL 344

Query: 325 ETVFITYLLH 334
           E V+I YL +
Sbjct: 345 EYVYINYLFY 354


>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 62/277 (22%), Positives = 125/277 (45%), Gaps = 21/277 (7%)

Query: 76  LGVDAQLQLLTSFLWMDL----------VWDNPFINWNPKECVGINKLTVLAENLWLPDI 125
           +GVD Q++ L S   +D+           W +  +++     + +     L + +W+PD+
Sbjct: 99  VGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDM 158

Query: 126 FIVESMDV---DQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSS 182
           F V S      D T   +   +  +G++ Y   + VT++CN+D   FP D Q C+    S
Sbjct: 159 FFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIES 218

Query: 183 FLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSM--GNNLYDQIMFY 240
           + YT D ++L   K+  +   T  ++  +Q    L+     T K++       Y+++   
Sbjct: 219 YAYTEDDLMLYW-KKGNDSLKTDERISLSQ---FLIQEFHTTTKLAFYSSTGWYNRLYIN 274

Query: 241 VAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES-ENRAPFKITLLLGYNVFLLMMNDL 299
             +RR    +++    P++ +V +  +SF++   +   R P  IT +L  +  +  +N  
Sbjct: 275 FTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNAS 334

Query: 300 LP-ASGTPLISVYFALCLSLMVVSLLETVFITYLLHV 335
           +P  S    + +Y  +    + +S+LE   + YL  V
Sbjct: 335 MPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTV 371


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 84/393 (21%), Positives = 161/393 (40%), Gaps = 31/393 (7%)

Query: 76  LGVDAQLQLLTSFLWMDL----------VWDNPFINWNPKECVGINKLTVLAENLWLPDI 125
           +GVD Q++ L S   +D+           W +  + ++      +     L + +W+PD+
Sbjct: 104 VGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDV 163

Query: 126 FIVES---MDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSS 182
           F V S      D T   +   +  +G + Y   + VT++CN+D  +FP D Q C+    S
Sbjct: 164 FFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELES 223

Query: 183 FLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINK--ATPKMSM--GNNLYDQIM 238
           + YT + ++L      W+  D S K  +     + L I K   T +++       Y+++ 
Sbjct: 224 YAYTDEDLML-----YWKNGDESLKTDEKISLSQFL-IQKFHTTSRLAFYSSTGWYNRLY 277

Query: 239 FYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES-ENRAPFKITLLLGYNVFLLMMN 297
               +RR    +++    P++ +V +  +SF++   +   R    IT +L     +  +N
Sbjct: 278 INFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVN 337

Query: 298 DLLP-ASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSL--LLHC 354
             +P  S    + +Y  +    + +S+LE   + YL  V   +   +      +  +LH 
Sbjct: 338 ASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHS 397

Query: 355 TSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLG-PRETEPDGGSGWTKTQLME 413
            +       +  + N   G   +H+   +E  +     LG   E       G  K Q   
Sbjct: 398 KTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGF 457

Query: 414 LWVQFSHAMDTLLFRLYLLFMASSILTVIVLWN 446
              Q +HA+D       L+F AS I   ++ W+
Sbjct: 458 RIFQNTHAIDKY---SRLIFPASYIFFNLIYWS 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,945,972
Number of Sequences: 37866
Number of extensions: 867501
Number of successful extensions: 2795
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2611
Number of HSP's gapped (non-prelim): 99
length of query: 447
length of database: 18,247,518
effective HSP length: 105
effective length of query: 342
effective length of database: 14,271,588
effective search space: 4880883096
effective search space used: 4880883096
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.