Guide to the Human Genome
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Search of human proteins with 47132532

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo
sapiens]
         (1137 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi...  2274   0.0  
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi...  2274   0.0  
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi...  1370   0.0  
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]            867   0.0  
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]            682   0.0  
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]             428   e-119
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]   152   2e-36
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]   152   2e-36
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi...   143   1e-33
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi...   134   4e-31
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]            126   1e-28
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                  84   6e-16
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]             80   8e-15
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...    80   1e-14
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...    80   1e-14
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]               78   5e-14
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]              75   5e-13
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]             72   4e-12
gi|239735519 SET binding factor 1 [Homo sapiens]                       70   1e-11
gi|29788755 SET binding factor 2 [Homo sapiens]                        68   6e-11
gi|209863002 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209862998 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209862994 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|18860873 MAP-kinase activating death domain-containing protei...    62   4e-09
gi|209862987 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209862983 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209862979 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209862975 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209862971 MAP-kinase activating death domain-containing prote...    62   4e-09
gi|209571517 MAP-kinase activating death domain-containing prote...    62   4e-09

>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 2274 bits (5892), Expect = 0.0
 Identities = 1137/1137 (100%), Positives = 1137/1137 (100%)

Query: 1    MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60
            MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH
Sbjct: 1    MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60

Query: 61   SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG 120
            SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG
Sbjct: 61   SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG 120

Query: 121  AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR 180
            AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR
Sbjct: 121  AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR 180

Query: 181  MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET 240
            MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET
Sbjct: 181  MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET 240

Query: 241  EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL 300
            EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL
Sbjct: 241  EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL 300

Query: 301  PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST 360
            PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST
Sbjct: 301  PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST 360

Query: 361  KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP 420
            KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP
Sbjct: 361  KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP 420

Query: 421  PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK 480
            PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK
Sbjct: 421  PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK 480

Query: 481  STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP 540
            STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP
Sbjct: 481  STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP 540

Query: 541  PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST 600
            PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST
Sbjct: 541  PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST 600

Query: 601  TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR 660
            TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR
Sbjct: 601  TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR 660

Query: 661  FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY 720
            FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY
Sbjct: 661  FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY 720

Query: 721  QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC 780
            QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC
Sbjct: 721  QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC 780

Query: 781  RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA 840
            RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA
Sbjct: 781  RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA 840

Query: 841  PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI 900
            PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI
Sbjct: 841  PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI 900

Query: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960
            FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK
Sbjct: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960

Query: 961  ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN 1020
            ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN
Sbjct: 961  ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN 1020

Query: 1021 TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ 1080
            TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ
Sbjct: 1021 TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ 1080

Query: 1081 MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137
            MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Sbjct: 1081 MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137


>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 2274 bits (5892), Expect = 0.0
 Identities = 1137/1137 (100%), Positives = 1137/1137 (100%)

Query: 1    MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60
            MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH
Sbjct: 1    MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60

Query: 61   SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG 120
            SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG
Sbjct: 61   SSSRVLLKDRHPPAPSPQNPQDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQG 120

Query: 121  AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR 180
            AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR
Sbjct: 121  AAQDVAGVAACLPLAQSTPFPGPAAGPRGVLLTRTGTRAHSLGIREKISAWEGRREASPR 180

Query: 181  MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET 240
            MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET
Sbjct: 181  MSMCGEKREGSGSEWAASEGCPSLGCPSVVPSPCSSEKTFDFKGLRRMSRTFSECSYPET 240

Query: 241  EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL 300
            EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL
Sbjct: 241  EEEGEALPVRDSFYRLEKRLGRSEPSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGL 300

Query: 301  PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST 360
            PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST
Sbjct: 301  PQLPSSCYSVDRGKRKTGTLGSLEEPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGST 360

Query: 361  KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP 420
            KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP
Sbjct: 361  KPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPPSPTPAAPP 420

Query: 421  PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK 480
            PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK
Sbjct: 421  PLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK 480

Query: 481  STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP 540
            STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP
Sbjct: 481  STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP 540

Query: 541  PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST 600
            PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST
Sbjct: 541  PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST 600

Query: 601  TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR 660
            TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR
Sbjct: 601  TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR 660

Query: 661  FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY 720
            FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY
Sbjct: 661  FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY 720

Query: 721  QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC 780
            QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC
Sbjct: 721  QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC 780

Query: 781  RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA 840
            RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA
Sbjct: 781  RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA 840

Query: 841  PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI 900
            PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI
Sbjct: 841  PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI 900

Query: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960
            FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK
Sbjct: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960

Query: 961  ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN 1020
            ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN
Sbjct: 961  ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN 1020

Query: 1021 TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ 1080
            TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ
Sbjct: 1021 TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ 1080

Query: 1081 MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137
            MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Sbjct: 1081 MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137


>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapiens]
          Length = 717

 Score = 1370 bits (3545), Expect = 0.0
 Identities = 693/696 (99%), Positives = 694/696 (99%)

Query: 442  RKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY 501
            R + SRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY
Sbjct: 22   RGTLSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY 81

Query: 502  EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER 561
            EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER
Sbjct: 82   EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER 141

Query: 562  KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN 621
            KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN
Sbjct: 142  KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN 201

Query: 622  SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY 681
            SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY
Sbjct: 202  SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY 261

Query: 682  RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA 741
            RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA
Sbjct: 262  RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA 321

Query: 742  IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR 801
            IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR
Sbjct: 322  IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR 381

Query: 802  LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL 861
            LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL
Sbjct: 382  LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL 441

Query: 862  RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY 921
            RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY
Sbjct: 442  RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY 501

Query: 922  PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM 981
            PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM
Sbjct: 502  PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM 561

Query: 982  DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY 1041
            DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY
Sbjct: 562  DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY 621

Query: 1042 SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE 1101
            SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE
Sbjct: 622  SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE 681

Query: 1102 QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137
            QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Sbjct: 682  QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 717



 Score = 60.5 bits (145), Expect = 9e-09
 Identities = 36/86 (41%), Positives = 44/86 (51%), Gaps = 3/86 (3%)

Query: 1  MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60
          MTMTANKNSSITHGAGGTKAPRGTLSR          +     +YP S +E      P  
Sbjct: 1  MTMTANKNSSITHGAGGTKAPRGTLSRKSFEFED---ASSLQSLYPSSPTENGTENQPKF 57

Query: 61 SSSRVLLKDRHPPAPSPQNPQDPSPD 86
           S   L ++ +         ++P  D
Sbjct: 58 GSKSTLEENAYEDIVGDLPKENPYED 83


>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
          Length = 1009

 Score =  867 bits (2240), Expect = 0.0
 Identities = 514/1008 (50%), Positives = 662/1008 (65%), Gaps = 59/1008 (5%)

Query: 154  RTGTRAHSLGIREKISAWEGRREA-SPRMSMCGEKRE----GSGSEWAASEGCPSLGCPS 208
            R   R  SL I++KIS WEG++E  +P  S   + +E     S  E  +S+G  +    +
Sbjct: 36   RARPRHKSLNIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEA 95

Query: 209  ---VVPSPCSSEKTFDFKGLRRMSRTFSECSYPETEEEGEALPVRDSFYR-LEKRLGRSE 264
               + P   S+EK  + KG   +     E     ++ E E  P   S+ R  E RLG+  
Sbjct: 96   KNGMRPGTESTEKERN-KGAVNVGGQDPEPGQDLSQPEREVDP---SWGRGREPRLGKLR 151

Query: 265  PSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGLPQLPSSCYSVDRGKRKTGTLGSLE 324
                      + +  +VL +++K+EQ LK+      PQLP +CYS      K     +L 
Sbjct: 152  ---------FQNDPLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLP 202

Query: 325  EPAGGASVSAGSRAVGVAGVAGEAGPPPE--REGSGSTKPGTPGNSPSSQRLPSKSSLDP 382
            E  GG S S  S+ V  + + G   P PE   +  GS +     +  +  R    S   P
Sbjct: 203  ENLGGGSGSEVSQRVHPSDLEGRE-PTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKP 261

Query: 383  AVNPVPKPKRTFEYEADKNPKSKPSNG-------LPPSPTPAAPPPLPSTPAPPVTRRPK 435
             +NP+PKP+RTF++  + +   KP  G       LPP P+   PPPLPS+P P    R  
Sbjct: 262  FINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLPS-LPPPPLPSSPPPSSVNRRL 320

Query: 436  KDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTL-EENAYEDIVGD 494
               R    +  RKS+EFED   LQS   SS  +     Q K G   TL EEN YEDI+  
Sbjct: 321  WTGRQKSSADHRKSYEFEDL--LQSSSESSRVD--WYAQTKLGLTRTLSEENVYEDILDP 376

Query: 495  LPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLR 554
              KENPYED++L  R  G+K           L+   SP     +S P  L+ +  S+   
Sbjct: 377  PMKENPYEDIELHGRCLGKKCV---------LNFPASPT----SSIPDTLTKQSLSKPAF 423

Query: 555  SGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIP 614
                SER++ +L    K  S D     +++S PS+PSS  +D      +  + R+ R+IP
Sbjct: 424  FRQNSERRNFKLLDTRKL-SRDGTGSPSKISPPSTPSS-PDDIFFNLGDPQNGRKKRKIP 481

Query: 615  KLVQRINSIYNAKRGKKRLKKLSMS-SIETASLRDENSESESDSDDRFKAHTQRLVHIQS 673
            KLV RIN+IY  +RGKKR+K+LS S    +  + DENSES+SD++++ KAH+QRLV+++S
Sbjct: 482  KLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKS 541

Query: 674  MLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFP-KLDRPTKQM 732
             LK+AP Y +L  EL+E+QER+LFEYFVVVSL KK +   Y+PE++ QFP KL+R  K M
Sbjct: 542  RLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFM 601

Query: 733  REAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRL 792
            REAE++LKAIPQFCFPDAKDW+PV +++SETFSF+LTGEDGSRRFGYCRRLLP GKG RL
Sbjct: 602  REAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRL 661

Query: 793  PEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLP 852
            PEVYC++SRLGCF LFS++LDEVE+RRGIS ALV P MRS+ME+PFPA GKTI VK FLP
Sbjct: 662  PEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLP 721

Query: 853  GAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSC 912
            G+G EV+EL RP+DSRLEHVDFE LF+ LSVR L+ +FASLLLERRVIF+ADKLS LS C
Sbjct: 722  GSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKC 781

Query: 913  SHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNL 972
             HA+VAL+YPF+WQHT+IPVLP +M+DIVC PTPFL+GLLSSSLP L+ELP+EE L+V+L
Sbjct: 782  CHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDL 841

Query: 973  GSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSD----DECNTLNGLVSE 1028
             + RF+RQMDDED++LPRKLQ ALE  LE++NEL  +  +   D     E + LN +VSE
Sbjct: 842  VNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSE 901

Query: 1029 VFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQD 1088
             F+RFFVE VGHYSLFLT  E+ ER  QREAFRK+V+SKS+R FLEVFME+QMF GFIQ+
Sbjct: 902  AFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961

Query: 1089 RELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKK 1136
            RELR+  AKGLFE R ++YLE LP  E SG+NKFL+GLGNKMKFLHKK
Sbjct: 962  RELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score =  682 bits (1760), Expect = 0.0
 Identities = 355/603 (58%), Positives = 451/603 (74%), Gaps = 13/603 (2%)

Query: 535  RKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLN 594
            R  NS   +  L  NS S      SE   +     P + +  + + +  L +  SPS+  
Sbjct: 281  RNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAW- 339

Query: 595  EDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESE 654
                    +L  ++ A + PKLV +I+ I+ +KRGKK++K  S +  E    + E S +E
Sbjct: 340  --------KLPPAKSAFKAPKLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNE 391

Query: 655  SDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTY 714
            SD++   K   +RL  +Q   KR P Y+TLE +L+E QE++LFE FVVVSL+KKPS  +Y
Sbjct: 392  SDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISY 451

Query: 715  LPEVSYQFP-KLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDG 773
            +P+V  QFP K D   KQ ++ EERLK IP+FCFPD+KDW+P SE  SETFSF+LTGEDG
Sbjct: 452  IPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDG 511

Query: 774  SRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL 833
            SR FGYC++LLP GKG RLPEVYC++SRLGCF LFSK+LDEVE+RR +S ALVYPFMRS+
Sbjct: 512  SRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSV 571

Query: 834  MESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASL 893
            ME+PFPAPG+TI VK++LPGAG+E +EL RP+DSRLEHVDF+CLF CLSV  LIR+ ASL
Sbjct: 572  MEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASL 631

Query: 894  LLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLS 953
            LLERRVIFVA+ LSTLS C HAVVA LYPF+WQHT+IPVLPASMIDIVC PTPFL+G+LS
Sbjct: 632  LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691

Query: 954  SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDS 1013
             SLP+L++LP+EE L+V+L +D+F++++ DED +LP KLQAAL Q LE +NE+++Q+ + 
Sbjct: 692  CSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNF 751

Query: 1014 DSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFL 1073
              D    TLN LVSE F+RFFVE VGHYSL +T +E+GER FQRE FRKS  S+S+R FL
Sbjct: 752  SQD---VTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFL 808

Query: 1074 EVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFL 1133
            ++FME+QMFAGFIQDRELRK   KGLFE R  QYLE +P++E SGMN+ LR LG+KMKFL
Sbjct: 809  DLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFL 868

Query: 1134 HKK 1136
             KK
Sbjct: 869  QKK 871


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score =  428 bits (1101), Expect = e-119
 Identities = 211/419 (50%), Positives = 294/419 (70%), Gaps = 12/419 (2%)

Query: 694  RELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERL-KAIPQFCFPDAKD 752
            +  FEY +VVSLKKK S + Y P ++YQFPK +   +  +E EERL KAIP FCFPD  +
Sbjct: 51   QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110

Query: 753  WLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVL 812
            W  ++EY  ETFSF+LT  DGSR+ GYCRRLLP+G GPRLP+VYC+IS +GCFGLFSK+L
Sbjct: 111  WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170

Query: 813  DEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHV 872
            DEVE+R  IS A++YPFM+ L E+ FPAPGKT+ +K+F+P +G E + L RP+DS LEHV
Sbjct: 171  DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230

Query: 873  DFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPV 932
            DF  L  CLS  Q+++IFAS +LER++IF+A+ LSTLS C HA  ALLYPFSW HT+IPV
Sbjct: 231  DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290

Query: 933  LPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 992
            +P S++  VCCPTPF+VG+      ++ + P+EE L+VNL    F+  + DE  +LP KL
Sbjct: 291  VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350

Query: 993  QAALEQAL-ERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKG 1051
            Q  +  +L +  NEL + +           +N  VS  F++FFV+ VGHY+ ++ +   G
Sbjct: 351  QDDILDSLGQGINELKTAEQ----------INEHVSGPFVQFFVKIVGHYASYIKREANG 400

Query: 1052 ERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEE 1110
            +  FQ  +F K++ SK+ RRF++ F+++Q+F+ FIQ+ E  K    G F+Q++ +Y E+
Sbjct: 401  QGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQ 459


>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
          Length = 559

 Score =  152 bits (383), Expect = 2e-36
 Identities = 107/379 (28%), Positives = 185/379 (48%), Gaps = 43/379 (11%)

Query: 716  PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 775
            PEV  QFP       +    +E L+ + +FCFP   D L VS+   + F+F+LT  D  +
Sbjct: 31   PEVQRQFP-------EDYSDQEVLQTLTKFCFPFYVDSLTVSQVG-QNFTFVLTDIDSKQ 82

Query: 776  RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLD-----EVERRRGISAALVYPFM 830
            RFG+CR  L SG        +C++S L  F +F K+L+       +R+      L    +
Sbjct: 83   RFGFCR--LSSGA----KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNEL----L 132

Query: 831  RSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIF 890
             +L + P P PG ++ +         +  EL    ++R    +    F  + V  ++ ++
Sbjct: 133  ETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENR----NLTEYFVAVDVNNMLHLY 188

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950
            AS+L ERR++ +  KLSTL++C H   A+LYP  WQH +IPVLP  ++D  C P P+L+G
Sbjct: 189  ASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIG 248

Query: 951  LLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQD 1010
            +  S + K++ + +++ +++N+ ++      DD  + LP  + ++L+  L++ +      
Sbjct: 249  IHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQS-LPNDVISSLKNRLKKVS------ 301

Query: 1011 SDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIR 1070
                      T    V+  F++      G Y   L    +    F  EAF     S ++R
Sbjct: 302  ---------TTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMR 352

Query: 1071 RFLEVFMESQMFAGFIQDR 1089
            +FL+   + Q+F  FI  R
Sbjct: 353  QFLQNATQLQLFKQFIDGR 371


>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
          Length = 1009

 Score =  152 bits (383), Expect = 2e-36
 Identities = 107/379 (28%), Positives = 185/379 (48%), Gaps = 43/379 (11%)

Query: 716  PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 775
            PEV  QFP       +    +E L+ + +FCFP   D L VS+   + F+F+LT  D  +
Sbjct: 31   PEVQRQFP-------EDYSDQEVLQTLTKFCFPFYVDSLTVSQVG-QNFTFVLTDIDSKQ 82

Query: 776  RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLD-----EVERRRGISAALVYPFM 830
            RFG+CR  L SG        +C++S L  F +F K+L+       +R+      L    +
Sbjct: 83   RFGFCR--LSSGA----KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNEL----L 132

Query: 831  RSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIF 890
             +L + P P PG ++ +         +  EL    ++R    +    F  + V  ++ ++
Sbjct: 133  ETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENR----NLTEYFVAVDVNNMLHLY 188

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950
            AS+L ERR++ +  KLSTL++C H   A+LYP  WQH +IPVLP  ++D  C P P+L+G
Sbjct: 189  ASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIG 248

Query: 951  LLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQD 1010
            +  S + K++ + +++ +++N+ ++      DD  + LP  + ++L+  L++ +      
Sbjct: 249  IHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQS-LPNDVISSLKNRLKKVS------ 301

Query: 1011 SDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIR 1070
                      T    V+  F++      G Y   L    +    F  EAF     S ++R
Sbjct: 302  ---------TTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMR 352

Query: 1071 RFLEVFMESQMFAGFIQDR 1089
            +FL+   + Q+F  FI  R
Sbjct: 353  QFLQNATQLQLFKQFIDGR 371



 Score = 37.4 bits (85), Expect = 0.082
 Identities = 34/101 (33%), Positives = 39/101 (38%), Gaps = 20/101 (19%)

Query: 340 GVAGVAGEAG----PPPEREGSGSTKPGTPGNSPSSQRLPSKSSLDPAVNPVPKPKRTFE 395
           G AG + +A      P     SGST P  P     +     + S  PA  P P P+    
Sbjct: 773 GAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQ---- 828

Query: 396 YEADKNPKSKPSNGLPPSPTPAAPPPLP--STPAPPVTRRP 434
                     P N   PS  PAAPP LP  STPA P    P
Sbjct: 829 ---------PPLNPFVPS-MPAAPPTLPLVSTPAGPFGAPP 859



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 30/117 (25%), Positives = 45/117 (38%), Gaps = 19/117 (16%)

Query: 21  PRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSHSSSRVLLKDRHPPAPSPQNP 80
           P GT +       PP ++P R    PL+ S   A    + +   + L+   PP   P+ P
Sbjct: 900 PMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARA----AETKQGLALRPGDPPLLPPRPP 955

Query: 81  QDPSPDTSPPTCPFKTASFGYLDRSPSACKRDAQKESVQGAAQDVAGVAACLPLAQS 137
           Q   P T  P+ P +               RD  ++ +Q   QDV+   A  P   S
Sbjct: 956 QGLEP-TLQPSAPQQA--------------RDPFEDLLQKTKQDVSPSPALAPAPDS 997


>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapiens]
          Length = 755

 Score =  143 bits (360), Expect = 1e-33
 Identities = 105/378 (27%), Positives = 183/378 (48%), Gaps = 42/378 (11%)

Query: 736  EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 795
            +E L+++P+FCFP   + +  ++     F+F+LT  +  +RFG+CR  L SG    L   
Sbjct: 42   QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95

Query: 796  YCVISRLGCFGLFSKVLDEV------ERRRGISAALVYPFMRSLMESPFPAPGKTIKVKT 849
             C++S L  F ++ K+L+ +      E    ++  L     RSL   P P     + +  
Sbjct: 96   -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETL-----RSLYNHPVPKANTPVNLSV 149

Query: 850  FLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTL 909
                   +V  L    +SR    +    F  + V  +++++AS+L ERR++ ++ KLSTL
Sbjct: 150  HSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL 205

Query: 910  SSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALM 969
            ++C H   ALLYP  WQH +IPVLP  ++D  C P P+L+G+ SS + ++K   +E+ +M
Sbjct: 206  TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM 265

Query: 970  VNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEV 1029
            +N+ ++       D +  LP  + +AL+  L++++                     V+  
Sbjct: 266  LNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG---------------VARA 309

Query: 1030 FIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDR 1089
            F+R      G Y   L         F  E+F K   S  +++FLE  +  Q+F  FI  R
Sbjct: 310  FLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGR 368

Query: 1090 ELRKCRAKG---LFEQRV 1104
              +    +G   +FE+ +
Sbjct: 369  LAKLNAGRGFSDVFEEEI 386


>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapiens]
          Length = 426

 Score =  134 bits (338), Expect = 4e-31
 Identities = 104/389 (26%), Positives = 186/389 (47%), Gaps = 44/389 (11%)

Query: 736  EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 795
            +E L+++P+FCFP   + +  ++     F+F+LT  +  +RFG+CR  L SG    L   
Sbjct: 42   QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95

Query: 796  YCVISRLGCFGLFSKVLD--------EVERRRGISAALVY---------PFMRSLMESPF 838
             C++S L  F ++ K+L+        E+E     +   +Y         P   S+ +  F
Sbjct: 96   -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIF 154

Query: 839  PAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERR 898
             A  + +K +  L      +      + +  E  +    F  + V  +++++AS+L ERR
Sbjct: 155  IACEQVLKDQPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERR 214

Query: 899  VIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPK 958
            ++ ++ KLSTL++C H   ALLYP  WQH +IPVLP  ++D  C P P+L+G+ SS + +
Sbjct: 215  IVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIER 274

Query: 959  LKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDE 1018
            +K   +E+ +M+N+ ++       D +  LP  + +AL+  L++++              
Sbjct: 275  VKNKSLEDVVMLNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG-------- 325

Query: 1019 CNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFME 1078
                   V+  F+R      G Y   L         F  E+F K   S  +++FLE  + 
Sbjct: 326  -------VARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN 377

Query: 1079 SQMFAGFIQDRELRKCRAKG---LFEQRV 1104
             Q+F  FI  R  +    +G   +FE+ +
Sbjct: 378  LQLFKQFIDGRLAKLNAGRGFSDVFEEEI 406


>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
          Length = 801

 Score =  126 bits (317), Expect = 1e-28
 Identities = 110/406 (27%), Positives = 181/406 (44%), Gaps = 49/406 (12%)

Query: 716  PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 775
            P +  QFP   R        +E ++ +P+FCFP   +  P S  + + F+F LT   G+R
Sbjct: 29   PPILRQFPPDFRD-------QEAMQMVPKFCFPFDVEREPPSP-AVQHFTFALTDLAGNR 80

Query: 776  RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEV-ERRRGISAALVYPFMRSLM 834
            RFG+CR  L +G    L    C++S L  F +F K+L+ V +             +++L 
Sbjct: 81   RFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 134

Query: 835  ESPFPAP----------GKTIKVKTFLP----GAGNEVLELRRPMDSRL----EHVDFEC 876
            +     P          G T+     +P    G    +     P   RL    E+ +   
Sbjct: 135  QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 194

Query: 877  LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPAS 936
            L   ++   ++ +FA+LL ERRV+  A KLSTL+SC HA  ALLYP  W+H  IP LP  
Sbjct: 195  LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 254

Query: 937  MIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAAL 996
            ++D  C P P+L+G+ +S   +++E  +E+ +++N+ ++      +D   L P  +  +L
Sbjct: 255  LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVV--SL 312

Query: 997  EQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQ 1056
             +   RK  L   +               VS +F++      G Y   L  S      F 
Sbjct: 313  LRLRLRKVALAPGEG--------------VSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358

Query: 1057 REAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQ 1102
             E F        ++ F    +  Q+F  FI+ R  +  + +G  +Q
Sbjct: 359  EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQ 404


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 8/168 (4%)

Query: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 890
           L E P P PG+++K      G    ++  +RP  + L   DF    +F  L V  + ++F
Sbjct: 248 LYEVPLPPPGRSLKFS----GVYGPII-CQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302

Query: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950
              LLE +++  +     L + +  + AL++PF WQH ++P+LPAS++  +  P P+L+G
Sbjct: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362

Query: 951 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE 997
           L S+ L    +L + +EA +  +  D    ++ ++    P KL+   E
Sbjct: 363 LHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQE 410



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 12/114 (10%)

Query: 988  LPRKLQAALEQALERKNELISQDSDSDSDDE---CNTLNGLVSEVFIRFFVETVGHYSLF 1044
            L ++   +LE+   R++   ++D     D+E      LN  + EVF   F +    Y +F
Sbjct: 475  LVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVF 534

Query: 1045 LTQSEKGERAF-----QREAFRK----SVASKSIRRFLEVFMESQMFAGFIQDR 1089
            + Q  + + ++     Q + F K    S   +    FL  F+E+QMFA FI ++
Sbjct: 535  VIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNK 588


>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
          Length = 1274

 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 50/165 (30%), Positives = 85/165 (51%), Gaps = 12/165 (7%)

Query: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 890
           L E P P PG+++K          E +  +RP  S L   D+     F  L +  L+++F
Sbjct: 233 LYEVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287

Query: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950
             +LLE +++  +     L + +  +  LL+PF WQH ++P+LPAS++  +  P P+L+G
Sbjct: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347

Query: 951 LLS---SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 992
           L S   +   KL ELP +EA +  +  D    ++ +E    P K+
Sbjct: 348 LQSKEGTDRSKL-ELP-QEANLCFVDIDNHFIELPEEFPQFPNKV 390



 Score = 31.2 bits (69), Expect = 5.9
 Identities = 26/98 (26%), Positives = 46/98 (46%), Gaps = 13/98 (13%)

Query: 1022 LNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAF-----QREAFRK----SVASKSIRRF 1072
            LN  + EVF   F +    Y  F+ Q+ +   ++     Q + F K    S   +    F
Sbjct: 498  LNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPF 557

Query: 1073 LEVFMESQMFAGFIQDRELRKCRAKG----LFEQRVEQ 1106
            L  F+E+QMFA FI ++ + +   K     +F+ R+++
Sbjct: 558  LSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDK 595


>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapiens]
          Length = 1906

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)

Query: 718  VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 773
            VSY+   + R  ++  E+    +++P FC P     + W   S+Y    FS F+LTG   
Sbjct: 206  VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265

Query: 774  SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 808
             + +G                 +RLL           S K     +  C++S    F  F
Sbjct: 266  EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325

Query: 809  SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 864
             K L  + R   IS   V P  + +     + PFP+P +   +    P   ++ L L +P
Sbjct: 326  RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381

Query: 865  MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 922
            + S L      F  L   L     + +    + E +++  + + S L+S + A+V++++P
Sbjct: 382  VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441

Query: 923  FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 982
            F W   ++P+ P ++ D++  P PF+VG+ S         P    + V+  +   I Q+ 
Sbjct: 442  FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498

Query: 983  DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 1022
            D+      +LP+K           L   L +  +R       +L   D D +S    + +
Sbjct: 499  DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558

Query: 1023 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 1074
            +  + E F+ F    +  Y  +L       SE    A   F  +AF +S   +S ++F  
Sbjct: 559  DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617

Query: 1075 VFMESQMFAGFIQD 1088
            +  ++QMF  FI++
Sbjct: 618  MMTKTQMFIRFIEE 631


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapiens]
          Length = 1863

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)

Query: 718  VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 773
            VSY+   + R  ++  E+    +++P FC P     + W   S+Y    FS F+LTG   
Sbjct: 206  VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265

Query: 774  SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 808
             + +G                 +RLL           S K     +  C++S    F  F
Sbjct: 266  EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325

Query: 809  SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 864
             K L  + R   IS   V P  + +     + PFP+P +   +    P   ++ L L +P
Sbjct: 326  RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381

Query: 865  MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 922
            + S L      F  L   L     + +    + E +++  + + S L+S + A+V++++P
Sbjct: 382  VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441

Query: 923  FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 982
            F W   ++P+ P ++ D++  P PF+VG+ S         P    + V+  +   I Q+ 
Sbjct: 442  FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498

Query: 983  DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 1022
            D+      +LP+K           L   L +  +R       +L   D D +S    + +
Sbjct: 499  DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558

Query: 1023 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 1074
            +  + E F+ F    +  Y  +L       SE    A   F  +AF +S   +S ++F  
Sbjct: 559  DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617

Query: 1075 VFMESQMFAGFIQD 1088
            +  ++QMF  FI++
Sbjct: 618  MMTKTQMFIRFIEE 631


>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
          Length = 1198

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 96/396 (24%), Positives = 157/396 (39%), Gaps = 48/396 (12%)

Query: 739  LKAIPQFCFPDAKDWLPVSEYSSETFSFM-LTGEDGSRRFG----YCRRL-----LPSGK 788
            L  +PQ CFP        +E   +   F+ LT   G+R +G    Y R L       +GK
Sbjct: 39   LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96

Query: 789  GPR------LPEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLME 835
              R      +P   CV+SR         C      +L   +     S    +    SL+ 
Sbjct: 97   THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156

Query: 836  SPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLL 895
            SP P P   +    F   +   VL  R   +S +  +D      C    ++++I   +L 
Sbjct: 157  SPPPGPLHLV----FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT 212

Query: 896  ERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSS 955
            E+R++F +   + L+  +   +A LYP  WQH F+P+L   M+D V  PT FL+G     
Sbjct: 213  EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDH 272

Query: 956  LPKL-KELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE-----QALERKNELISQ 1009
              ++ KE      + ++ GS  + +  DD   +    L AA       Q+L+  +EL + 
Sbjct: 273  FEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAA 332

Query: 1010 DSDSDSD---------DECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAF 1060
               S +D              LN  + +  ++  V         L       R F  E F
Sbjct: 333  HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVFNSEEF 389

Query: 1061 RKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRA 1096
             K+ A     +F +  +++ MF  F++ R  R+  A
Sbjct: 390  LKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRRMDA 424


>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
          Length = 1673

 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 88/416 (21%), Positives = 172/416 (41%), Gaps = 70/416 (16%)

Query: 753  WLPVSEYSSETFS-FMLTGEDGSRRFG--------YCRRLLPS----------------- 786
            W P ++Y    FS F+LTG    + +G        Y R LL                   
Sbjct: 8    WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67

Query: 787  GKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL----MESPFPAPG 842
             K     +  C++S    F  F K L  + +   +S     P  + +       PFP+P 
Sbjct: 68   SKSINTNKCICLLSHWPFFEAFRKFLMFIYKL-SVSGPHPLPIEKHISHFMQNIPFPSPQ 126

Query: 843  KTIKVKTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVI 900
            +    +  +  + ++ L L +P+ + L     +F  L   L       +   +LLE +++
Sbjct: 127  RP---RILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKIL 183

Query: 901  FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 960
              + + + L+  + AVVA+++PF WQ  +IP+ P S+  ++  P PF+VG + S    L 
Sbjct: 184  LHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVG-VDSRYFDLH 242

Query: 961  ELPVEEALMVNLGSDRFIRQMDDEDTL----LPRKLQAALEQALERKNELISQ------- 1009
            + P ++ + ++L ++  +   D++  +    LP+K    L   L++    +S        
Sbjct: 243  D-PPQDVVCIDLDTN-MLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300

Query: 1010 ---------DSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFL--------TQSEKGE 1052
                     ++D     +   L   + E F+RF    +  Y  +L         ++   +
Sbjct: 301  GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360

Query: 1053 RAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 1106
              F R+ F KS   ++  +F  +  ++Q+F  FI++      +  GL  F+  +E+
Sbjct: 361  SLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEK 415


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 105/455 (23%), Positives = 184/455 (40%), Gaps = 78/455 (17%)

Query: 720  YQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDGSR 775
            Y+   L R  ++  EA    +++P FC P     + W   ++Y    FS F+LTG  G +
Sbjct: 211  YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270

Query: 776  RFGYCRRLLPS---------------------------GKGPRLPEVYCVISRLGCFGLF 808
             +G   +   +                           G+  R      V+SR   F  F
Sbjct: 271  VYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAF 330

Query: 809  SKVLDEVER------RRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELR 862
               L  + R       R    A +  F+ ++   PFP+P +   +    P    + L L 
Sbjct: 331  RAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSP---YDNLLLC 384

Query: 863  RPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALL 920
            +P+ S L      F  L   L     I +  ++L E +++  + +   L+S   A+V+++
Sbjct: 385  QPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 444

Query: 921  YPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQ 980
            +P  WQ  +IP+ P  + D++  P PF+VG+ SS        P  + + V+L ++    Q
Sbjct: 445  FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLDTNTLF-Q 501

Query: 981  MDDEDTLLPRKLQ--------AALEQALERKNELISQDSD--------SDSDDECNTLNG 1024
             +++  L PR L         A L    ++ ++  +   +        +D +  C     
Sbjct: 502  TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRAR 561

Query: 1025 LVSEV---FIRFFVETVGHYSLF---LTQS-EKGER----AFQREAFRKSVASKSIRRFL 1073
            L  EV   F+RF    +  Y +F   LTQ+  +G R     F  + F KS   +S  +  
Sbjct: 562  LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-RERSSHKLY 620

Query: 1074 EVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 1106
               + +QMF+ FI++      R   L  F+  VE+
Sbjct: 621  SQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEK 655



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 60/248 (24%), Positives = 88/248 (35%), Gaps = 46/248 (18%)

Query: 316  KTGTLGSLE--EPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGSTKP---------GT 364
            K+G+LGS    +P   A V+    A+GV    G   P P  +GS S            G+
Sbjct: 960  KSGSLGSARGAQPTVEAGVAHMIEALGVLEPRGS--PVPWHDGSLSDLSLTGEEPLPGGS 1017

Query: 365  PGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPP-----------S 413
            PG S S+    S  +L+      PK          ++    P  GL             S
Sbjct: 1018 PGGSGSALSAQSTEALEGLSGRGPKAG------GRQDEAGTPRRGLGARLQQLLTPSRHS 1071

Query: 414  PTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTEN 473
            P    PPP      PP  RR   D   H + +   S   E ++SL           G+E 
Sbjct: 1072 PASRIPPPELPPDLPPPARRSPMDSLLHPRERP-GSTASESSASL-----------GSEW 1119

Query: 474  QPKFGSKSTLEENAYEDIVGDLPK--ENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWS 531
                 S S L      + + D P   ++P  ++ L S    R    L  +  + +   W+
Sbjct: 1120 DLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD--EEIMAGWA 1177

Query: 532  PQDRKYNS 539
            P D   N+
Sbjct: 1178 PDDSNLNT 1185


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 69/305 (22%), Positives = 134/305 (43%), Gaps = 37/305 (12%)

Query: 848  KTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADK 905
            +T   GAG+  + ++ P+   L         LF  L +  ++ +F + L E +V+F++  
Sbjct: 184  RTISLGAGDRQV-IQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRS 242

Query: 906  LSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVE 965
               L+     ++ALL+P  +  T++P+LPA +++++  PTPF++G+ ++   + +EL   
Sbjct: 243  YQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQEL--L 300

Query: 966  EALMVNLGSDRFIRQMDDEDTLLPRKLQ----AALEQALERKNEL--ISQDSDSDSDDEC 1019
            + ++ +L               LP  LQ    + L   L+ + EL  ++    + S    
Sbjct: 301  DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL 360

Query: 1020 NTLNGLVSEVFIRFFVETVGHYSLFL----TQSEKGERAFQREAF--RKSVASKSIRRFL 1073
               +  +  VF+R F + +  Y   L       E   R F + AF  ++ +       FL
Sbjct: 361  KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIR-FHKAAFLGQRGLVEDD---FL 416

Query: 1074 EVFMESQMFAGFIQDR----------------ELRKCRAKGLFEQRVEQYLEELPDTEQS 1117
               +E   FAGF+ +R                E+ + RA     QRV ++++EL +    
Sbjct: 417  MKVLEGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYK 476

Query: 1118 GMNKF 1122
              N +
Sbjct: 477  NENPY 481


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 112/494 (22%), Positives = 190/494 (38%), Gaps = 94/494 (19%)

Query: 696  LFEYFVVVSLK-KKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWL 754
            L +YF+VV    +KP     L ++  +FP+ D       +       I  FC P    W 
Sbjct: 4    LADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQG------IELFCQPGG--WQ 55

Query: 755  PVSEYSSETFSFM-LTGEDGSRRFGYCRRL------LPSGKGPRL--------------- 792
               E    TF  + LT  D  R +  C         L   K   +               
Sbjct: 56   LSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEV 115

Query: 793  --PEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGK 843
              P+   ++SRL        C GL   V  +      ++ +L    + +L     PA G 
Sbjct: 116  FAPKSLVLVSRLYYPEIFRACLGLIYTVYVD-----SLNVSLE-SLIANLCACLVPAAGG 169

Query: 844  TIKVKTFLPGAGNEVLELRRPMDSRLE--HVDFECLFTCLSVRQLIRIFASLLLERRVIF 901
            + K+  F  GAG+  L ++ P+   L         LF  L ++ ++ +F ++L E +V+F
Sbjct: 170  SQKL--FSLGAGDRQL-IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLF 226

Query: 902  VADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKE 961
             +     LS    A+ +L++P  + + +IP+LPA +++++  PTPF++G+ S     + E
Sbjct: 227  HSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE 286

Query: 962  LPVEEALMVNLGSDRFIRQMDDEDTLLPR--KLQAALEQALERKNELISQDSDSDSD--- 1016
            L            D  I  +D     +P    L +  E  L +    +S     D +   
Sbjct: 287  L-----------LDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVAD 335

Query: 1017 ----------DECNTLNGLVSEVFIRFFVETVGHY----SLFLTQSEKGERAFQREAF-- 1060
                           L+  V  VF+R F +    Y     L    +E     F + AF  
Sbjct: 336  HAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIH-FHKTAFLG 394

Query: 1061 RKSVASKSIRRFLEVFMESQMFAGFIQDR--ELRKCRAKGLFEQRVEQYLEELPDTEQS- 1117
            ++ +       FL   +    FAGF+ +R    R C    LF++ V   +E +   E + 
Sbjct: 395  QRGLVEND---FLTKVLSGMAFAGFVSERGPPYRSC---DLFDELVAFEVERIKVEENNP 448

Query: 1118 -GMNKFLRGLGNKM 1130
              M K +R L  ++
Sbjct: 449  VKMIKHVRELAEQL 462


>gi|209863002 MAP-kinase activating death domain-containing protein
            isoform j [Homo sapiens]
          Length = 1541

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862998 MAP-kinase activating death domain-containing protein
            isoform i [Homo sapiens]
          Length = 1544

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862994 MAP-kinase activating death domain-containing protein
            isoform d [Homo sapiens]
          Length = 1647

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|18860873 MAP-kinase activating death domain-containing protein
            isoform g [Homo sapiens]
          Length = 1581

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862987 MAP-kinase activating death domain-containing protein
            isoform f [Homo sapiens]
          Length = 1479

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862983 MAP-kinase activating death domain-containing protein
            isoform e [Homo sapiens]
          Length = 1608

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862979 MAP-kinase activating death domain-containing protein
            isoform c [Homo sapiens]
          Length = 1545

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862975 MAP-kinase activating death domain-containing protein
            isoform b [Homo sapiens]
          Length = 1565

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209862971 MAP-kinase activating death domain-containing protein
            isoform a [Homo sapiens]
          Length = 1588

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


>gi|209571517 MAP-kinase activating death domain-containing protein
            isoform h [Homo sapiens]
          Length = 1587

 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313

Query: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373

Query: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,337,266
Number of Sequences: 37866
Number of extensions: 2835979
Number of successful extensions: 29606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 1331
Number of HSP's that attempted gapping in prelim test: 16618
Number of HSP's gapped (non-prelim): 10035
length of query: 1137
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1024
effective length of database: 13,968,660
effective search space: 14303907840
effective search space used: 14303907840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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