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Search of human proteins with 46358417
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
(879 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 1791 0.0
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 1225 0.0
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 746 0.0
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 746 0.0
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 733 0.0
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 732 0.0
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 732 0.0
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 731 0.0
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 674 0.0
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 672 0.0
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 668 0.0
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 668 0.0
gi|37577159 calcium-sensing receptor [Homo sapiens] 419 e-117
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 375 e-104
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 300 3e-81
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 247 3e-65
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 229 6e-60
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 209 9e-54
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 124 5e-28
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 121 2e-27
gi|7706451 G protein-coupled receptor, family C, group 5, member... 66 1e-10
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 57 6e-08
gi|93204867 G protein-coupled receptor 158 [Homo sapiens] 56 2e-07
gi|93352554 GPR158-like 1 [Homo sapiens] 54 8e-07
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 51 4e-06
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 51 4e-06
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 51 4e-06
gi|4506403 G protein-coupled receptor, family C, group 5, member... 47 1e-04
gi|40217833 G protein-coupled receptor family C, group 5, member... 47 1e-04
gi|40217831 G protein-coupled receptor family C, group 5, member... 47 1e-04
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 1791 bits (4638), Expect = 0.0
Identities = 879/879 (100%), Positives = 879/879 (100%)
Query: 1 MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI 60
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
Sbjct: 1 MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI 60
Query: 61 NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV 120
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
Sbjct: 61 NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV 120
Query: 121 DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD 180
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
Sbjct: 121 DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD 180
Query: 181 KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC 240
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
Sbjct: 181 KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC 240
Query: 241 IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS 300
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
Sbjct: 241 IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS 300
Query: 301 DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ 360
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
Sbjct: 301 DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ 360
Query: 361 CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD 420
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
Sbjct: 361 CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD 420
Query: 421 AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY 480
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
Sbjct: 421 AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY 480
Query: 481 LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL 540
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
Sbjct: 481 LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL 540
Query: 541 ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK 600
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
Sbjct: 541 ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK 600
Query: 601 HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL 660
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
Sbjct: 601 HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL 660
Query: 661 TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA 720
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
Sbjct: 661 TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA 720
Query: 721 EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI 780
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
Sbjct: 721 EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI 780
Query: 781 IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH 840
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
Sbjct: 781 IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH 840
Query: 841 LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL 879
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
Sbjct: 841 LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL 879
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 1225 bits (3170), Expect = 0.0
Identities = 589/857 (68%), Positives = 711/857 (82%), Gaps = 14/857 (1%)
Query: 30 RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGV 89
++ + +EGDLVLGGLFP+++KG E+CG +NE RGIQRLEAMLFA+D IN+D +LLPGV
Sbjct: 23 KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGV 82
Query: 90 KLGVHILDTCSRDTYALEQSLEFVRASLTK-VDEAEYMCPDGSYAIQENIPLLIAGVIGG 148
+LG HILD+CS+DT+ALEQ+L+FVRASL++ D + ++CPDGSYA + P I GVIGG
Sbjct: 83 RLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGG 142
Query: 149 SYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFF 208
SYS VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDF+QAKAMAEILRFF
Sbjct: 143 SYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFF 202
Query: 209 NWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPN 268
NWTYVSTVASEGDYGETGIEAFE EAR RNIC+AT+EKVGR+ R +++ V+R LLQKP+
Sbjct: 203 NWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPS 262
Query: 269 ARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQ 328
ARV VLF RS+D+REL+AA+ R NASFTWVASDGWGA ES++ GSE A GAIT+ELAS
Sbjct: 263 ARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASY 322
Query: 329 PVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQES 388
P+ F YFQSL+P+NN RNPWFR+FWEQ+F+CS + +R C H ++ + +EQES
Sbjct: 323 PISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFR-----QRDCAAH-SLRAVPFEQES 376
Query: 389 KIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNK 448
KIMFVVNAVYAMAHALH M R LCPNTT+LCDAM+ ++G++LYKD++L + F APF P
Sbjct: 377 KIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRP-A 435
Query: 449 DADSIVKFDTFGDGMGRYNVFNFQNVG-GKYSYLKVGHWAETLSLDVNSIHWSRNS---V 504
D + V+FD FGDG+GRYN+F + G G+Y Y KVG+WAE L+LD + I W+ S +
Sbjct: 436 DTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPL 495
Query: 505 PTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYD 564
P S+CS+PC NE+K++QPG+VCCW+CIPC+PYEY DEFTC DCG G WP A LTGC++
Sbjct: 496 PASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFE 555
Query: 565 LPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGL 624
LP++YIRW DAWA+GPVTIACLG + T V+ VF++HN TP+VKASGRELCYILL GV L
Sbjct: 556 LPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFL 615
Query: 625 SYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFIS 684
YCMTF FIAKPS +C LRRLGLG++F++CYSALLTKTN IARIF G + GAQRP+FIS
Sbjct: 616 CYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFIS 675
Query: 685 PSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYD 744
P+SQV ICL LI Q+++V WL++EAPGT + T E+RE V L+CN +D+SML SL Y+
Sbjct: 676 PASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYN 735
Query: 745 VILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC 804
V+L+ LCT+YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC
Sbjct: 736 VLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC 795
Query: 805 ISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRF--SVSGTGTTYSQSSASTYV 862
+SVSLSG VVLGCLFAPK+HIILFQPQKNVV+HR +RF + + ++ Q S S +V
Sbjct: 796 VSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFV 855
Query: 863 PTVCNGREVLDSTTSSL 879
PTVCNGREV+DSTTSSL
Sbjct: 856 PTVCNGREVVDSTTSSL 872
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 746 bits (1926), Expect = 0.0
Identities = 391/821 (47%), Positives = 530/821 (64%), Gaps = 30/821 (3%)
Query: 33 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92
I+++GD++LGGLFP++ KG CG + +++GI RLEAML+AID+INKD LL + LG
Sbjct: 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLG 99
Query: 93 VHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSS 152
V ILDTCSRDTYALEQSL FV+A + K D ++ C +G I P I+GVIG + SS
Sbjct: 100 VRILDTCSRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASS 157
Query: 153 VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTY 212
VSI VAN+LRLF+IPQISYAST+ +LSD +RYD+F+R VPPD YQA+AM +I+ W Y
Sbjct: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217
Query: 213 VSTVASEGDYGETGIEAFEQEAR-LRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 271
VST+ASEG+YGE+G+EAF Q +R + +CIA ++K+ R ++ +I+ LL+ PNAR
Sbjct: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277
Query: 272 VVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELASQP 329
V++F DD R ++ AA + N S F W+ SD WG++ + + E +A GA+T+
Sbjct: 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337
Query: 330 VRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL--QNKRN-HRRVCD--KHLAIDSSNY 384
+ FDRYF+S NN RN WF +FWE+ F C L KRN H + C + +A DSS Y
Sbjct: 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSS-Y 396
Query: 385 EQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPF 444
EQE K+ FV++AVY+MA+ALH M + LCP LC M +DGK+L Y+ +NF
Sbjct: 397 EQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL-GYIRAVNF---- 451
Query: 445 NPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR--N 502
N A + V F+ GD GRY++F +Q Y +GHW L L V + W+ +
Sbjct: 452 --NGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509
Query: 503 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGC 562
+ P S CS PC P E K G CCW C CE Y Y DE +C C Q P + TGC
Sbjct: 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGC 569
Query: 563 YDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGV 622
+P + W WA+ PV +A LG + T V+ F+++N+TP+V+ASGREL Y+LL G+
Sbjct: 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGI 629
Query: 623 GLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKF 682
L Y +TF IA P +IC+ RR+ LG Y+ALLTKTN I RIF+ K PKF
Sbjct: 630 FLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKF 689
Query: 683 ISPSSQVFICLGLILVQIVMVSVWLILEAP------GTRRYTLAEKRETVILKCNVKDSS 736
ISP+SQ+ I LI VQ++ V VW +++ P G +R TL ++ +LKC++ D S
Sbjct: 690 ISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQR-TLDPEKARGVLKCDISDLS 748
Query: 737 MLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDY 796
++ SL Y ++L++ CTVYA KTR PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+
Sbjct: 749 LICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSA 808
Query: 797 R---VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834
+QTTT+ +S+SLS V LG L+ PKV+II+F P++NV
Sbjct: 809 EKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNV 849
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 746 bits (1926), Expect = 0.0
Identities = 391/821 (47%), Positives = 530/821 (64%), Gaps = 30/821 (3%)
Query: 33 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92
I+++GD++LGGLFP++ KG CG + +++GI RLEAML+AID+INKD LL + LG
Sbjct: 40 IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLG 99
Query: 93 VHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSS 152
V ILDTCSRDTYALEQSL FV+A + K D ++ C +G I P I+GVIG + SS
Sbjct: 100 VRILDTCSRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASS 157
Query: 153 VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTY 212
VSI VAN+LRLF+IPQISYAST+ +LSD +RYD+F+R VPPD YQA+AM +I+ W Y
Sbjct: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217
Query: 213 VSTVASEGDYGETGIEAFEQEAR-LRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 271
VST+ASEG+YGE+G+EAF Q +R + +CIA ++K+ R ++ +I+ LL+ PNAR
Sbjct: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277
Query: 272 VVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELASQP 329
V++F DD R ++ AA + N S F W+ SD WG++ + + E +A GA+T+
Sbjct: 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337
Query: 330 VRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL--QNKRN-HRRVCD--KHLAIDSSNY 384
+ FDRYF+S NN RN WF +FWE+ F C L KRN H + C + +A DSS Y
Sbjct: 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSS-Y 396
Query: 385 EQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPF 444
EQE K+ FV++AVY+MA+ALH M + LCP LC M +DGK+L Y+ +NF
Sbjct: 397 EQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL-GYIRAVNF---- 451
Query: 445 NPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR--N 502
N A + V F+ GD GRY++F +Q Y +GHW L L V + W+ +
Sbjct: 452 --NGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509
Query: 503 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGC 562
+ P S CS PC P E K G CCW C CE Y Y DE +C C Q P + TGC
Sbjct: 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGC 569
Query: 563 YDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGV 622
+P + W WA+ PV +A LG + T V+ F+++N+TP+V+ASGREL Y+LL G+
Sbjct: 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGI 629
Query: 623 GLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKF 682
L Y +TF IA P +IC+ RR+ LG Y+ALLTKTN I RIF+ K PKF
Sbjct: 630 FLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKF 689
Query: 683 ISPSSQVFICLGLILVQIVMVSVWLILEAP------GTRRYTLAEKRETVILKCNVKDSS 736
ISP+SQ+ I LI VQ++ V VW +++ P G +R TL ++ +LKC++ D S
Sbjct: 690 ISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQR-TLDPEKARGVLKCDISDLS 748
Query: 737 MLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDY 796
++ SL Y ++L++ CTVYA KTR PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+
Sbjct: 749 LICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSA 808
Query: 797 R---VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834
+QTTT+ +S+SLS V LG L+ PKV+II+F P++NV
Sbjct: 809 EKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNV 849
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 733 bits (1893), Expect = 0.0
Identities = 387/837 (46%), Positives = 521/837 (62%), Gaps = 31/837 (3%)
Query: 33 IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92
+++ G L LGGLFP++ +G CG++ +++G+ RLEAML+A+D +N D LLPGV+LG
Sbjct: 33 VRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLG 92
Query: 93 VHILDTCSRDTYALEQSLEFVRASLT---KVDEAEYMCPDGSYAIQENIPLLIAGVIGGS 149
+LDTCSRDTYALEQ+L FV+A + DE CP G ++ P + V+G S
Sbjct: 93 ARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGAS 152
Query: 150 YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFN 209
SSVSI VAN+LRLF IPQISYAST+ +LSD +RYD+F+R VPPD YQA+AM +I+R
Sbjct: 153 ASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALG 212
Query: 210 WTYVSTVASEGDYGETGIEAFEQEAR-LRNICIATAEKVGRSNIRKSYDSVIRELLQKPN 268
W YVST+ASEG+YGE+G+EAF Q +R +CIA + K+ R + VIR L++ PN
Sbjct: 213 WNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPN 272
Query: 269 ARVVVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELA 326
AR +++F DD R ++ AA +AN + F WV SD WGA+ S I E VA GAIT+
Sbjct: 273 ARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPK 332
Query: 327 SQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL-----QNKRNHRRVCDKHLAIDS 381
+ FD+YF + + NN RN WF +FWE+ F C L Q+ + R+ +
Sbjct: 333 RASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRD 392
Query: 382 SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFT 441
S YEQE K+ FV++AVYA+AHALH M + LCP T LC AM+ DG+ L + Y+ + F
Sbjct: 393 STYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQ-YIRAVRF- 450
Query: 442 APFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYS---YLKVGHWAETLSLDVNSIH 498
N A + V F+ GD GRY++F +Q G S Y VG WAETL LDV ++
Sbjct: 451 -----NGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQ 505
Query: 499 WSRN--SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPT 556
WS + VP+S CS PC P E K M G CCW C C+ Y + DEFTC C PT
Sbjct: 506 WSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPT 565
Query: 557 ADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCY 616
+ TGC P + W WA P+ +A LG + T VV F+++NNTP+V+ASGREL Y
Sbjct: 566 PNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSY 625
Query: 617 ILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNG 676
+LL G+ L Y +TF +A+P +CA RRL LG + YSALLTKTN I RIF+ K
Sbjct: 626 VLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRS 685
Query: 677 AQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGT-----RRYTLAEKRETVILKCN 731
P FISP+SQ+ I L +Q+V + WL P + + T+ ++ +LKC+
Sbjct: 686 VTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCD 745
Query: 732 VKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYV 791
+ D S++ L Y ++L++ CTVYA K R PE FNEAK IGFTMYTTCIIWLAF+PIF+
Sbjct: 746 MSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFG 805
Query: 792 TSSDYR---VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFS 845
T+ +QTTT+ +S+SLS V LG L+ PK ++ILF P++NV + L S
Sbjct: 806 TAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATS 862
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 732 bits (1889), Expect = 0.0
Identities = 387/849 (45%), Positives = 528/849 (62%), Gaps = 34/849 (4%)
Query: 7 LQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGI 66
L+VL AL + + G + I+IEGD+ LGGLFP++ KG CG I + GI
Sbjct: 21 LEVLLCALAAA----ARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGI 76
Query: 67 QRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM 126
RLEAML+A+D+IN D LLP V LG ILDTCSRDTYALEQSL FV+A + K D ++
Sbjct: 77 HRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQK-DTSDVR 135
Query: 127 CPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 186
C +G + P + GVIG S SSVSI VAN+LRLFQIPQISYAST+ +LSD RYD+
Sbjct: 136 CTNGEPPVFVK-PEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDF 194
Query: 187 FARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEAR-LRNICIATAE 245
F+R VPPD +QA+AM +I++ W YVST+ASEG YGE G+E+F Q ++ +CIA +
Sbjct: 195 FSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSV 254
Query: 246 KVGRSNIRKS--YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN--ASFTWVASD 301
++ + ++ +D +I++LL PN+R VV+F +D ++++AAA RA+ F WV SD
Sbjct: 255 RIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSD 314
Query: 302 GWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQC 361
WG++ + + E +A GAIT++ V FD YF S NN RN WF ++WE+ F C
Sbjct: 315 SWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNC 374
Query: 362 SL----QNKRNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTT 416
L K + R C I SNYEQE K+ FV++AVYAMAHALH M + LC +
Sbjct: 375 KLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYR 434
Query: 417 KLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVG- 475
+C M+ GKKL K Y+ +NF N A + V F+ GD GRY++F +Q
Sbjct: 435 GVCPEMEQAGGKKLLK-YIRNVNF------NGSAGTPVMFNKNGDAPGRYDIFQYQTTNT 487
Query: 476 GKYSYLKVGHWAETLSLDVNSIHWSRN--SVPTSQCSDPCAPNEMKNMQPGDVCCWICIP 533
Y +G W + L L++ + W + +P S C+ PC P + K Q G CCW C P
Sbjct: 488 SNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEP 547
Query: 534 CEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCM 593
C+ Y+Y DE TC C Q P + TGC D+P + W WA+ PV +A LG + T
Sbjct: 548 CDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIF 607
Query: 594 VVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFA 653
V+ FI++N+TP+V+ASGREL Y+LL G+ L Y +TF IAKP +C+ RR+ LG
Sbjct: 608 VMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMC 667
Query: 654 ICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPG 713
I Y+ALLTKTN I RIF+ K P+ ISP+SQ+ I LI VQ++ V +W ++ P
Sbjct: 668 ISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPN 727
Query: 714 -----TRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEA 768
T+ ++ +LKC++ D ++ SL Y ++L++ CTVYA KTR PENFNEA
Sbjct: 728 IIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEA 787
Query: 769 KFIGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCISVSLSGFVVLGCLFAPKVHI 825
K IGFTMYTTCI+WLAF+PIF+ T+ +QTTT+ IS++LS V LG L+ PKV+I
Sbjct: 788 KPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYI 847
Query: 826 ILFQPQKNV 834
I+F P+ NV
Sbjct: 848 IIFHPELNV 856
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 732 bits (1889), Expect = 0.0
Identities = 387/849 (45%), Positives = 528/849 (62%), Gaps = 34/849 (4%)
Query: 7 LQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGI 66
L+VL AL + + G + I+IEGD+ LGGLFP++ KG CG I + GI
Sbjct: 21 LEVLLCALAAA----ARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGI 76
Query: 67 QRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM 126
RLEAML+A+D+IN D LLP V LG ILDTCSRDTYALEQSL FV+A + K D ++
Sbjct: 77 HRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQK-DTSDVR 135
Query: 127 CPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 186
C +G + P + GVIG S SSVSI VAN+LRLFQIPQISYAST+ +LSD RYD+
Sbjct: 136 CTNGEPPVFVK-PEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDF 194
Query: 187 FARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEAR-LRNICIATAE 245
F+R VPPD +QA+AM +I++ W YVST+ASEG YGE G+E+F Q ++ +CIA +
Sbjct: 195 FSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSV 254
Query: 246 KVGRSNIRKS--YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN--ASFTWVASD 301
++ + ++ +D +I++LL PN+R VV+F +D ++++AAA RA+ F WV SD
Sbjct: 255 RIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSD 314
Query: 302 GWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQC 361
WG++ + + E +A GAIT++ V FD YF S NN RN WF ++WE+ F C
Sbjct: 315 SWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNC 374
Query: 362 SL----QNKRNHRRVCDKHLAIDS-SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTT 416
L K + R C I SNYEQE K+ FV++AVYAMAHALH M + LC +
Sbjct: 375 KLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYR 434
Query: 417 KLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVG- 475
+C M+ GKKL K Y+ +NF N A + V F+ GD GRY++F +Q
Sbjct: 435 GVCPEMEQAGGKKLLK-YIRNVNF------NGSAGTPVMFNKNGDAPGRYDIFQYQTTNT 487
Query: 476 GKYSYLKVGHWAETLSLDVNSIHWSRN--SVPTSQCSDPCAPNEMKNMQPGDVCCWICIP 533
Y +G W + L L++ + W + +P S C+ PC P + K Q G CCW C P
Sbjct: 488 SNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEP 547
Query: 534 CEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCM 593
C+ Y+Y DE TC C Q P + TGC D+P + W WA+ PV +A LG + T
Sbjct: 548 CDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIF 607
Query: 594 VVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFA 653
V+ FI++N+TP+V+ASGREL Y+LL G+ L Y +TF IAKP +C+ RR+ LG
Sbjct: 608 VMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMC 667
Query: 654 ICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPG 713
I Y+ALLTKTN I RIF+ K P+ ISP+SQ+ I LI VQ++ V +W ++ P
Sbjct: 668 ISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPN 727
Query: 714 -----TRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEA 768
T+ ++ +LKC++ D ++ SL Y ++L++ CTVYA KTR PENFNEA
Sbjct: 728 IIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEA 787
Query: 769 KFIGFTMYTTCIIWLAFLPIFYVTSSDYR---VQTTTMCISVSLSGFVVLGCLFAPKVHI 825
K IGFTMYTTCI+WLAF+PIF+ T+ +QTTT+ IS++LS V LG L+ PKV+I
Sbjct: 788 KPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYI 847
Query: 826 ILFQPQKNV 834
I+F P+ NV
Sbjct: 848 IIFHPELNV 856
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 731 bits (1888), Expect = 0.0
Identities = 398/861 (46%), Positives = 527/861 (61%), Gaps = 31/861 (3%)
Query: 10 LTLALFSKGFLLSLGD---HNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGI 66
L L+L+ SLG H + I+I+GD+ LGGLFP++ +G+ + CG + +++GI
Sbjct: 18 LLLSLYGPWMPSSLGKPKGHPHMN-SIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGI 76
Query: 67 QRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM 126
RLEAMLFA+D IN D LLP + LG ILDTCSRDT+ALEQSL FV+A + K D E
Sbjct: 77 HRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEK-DGTEVR 135
Query: 127 CPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY 186
C G I P + GVIG S SSVSI VAN+LRLF+IPQISYAST+ LSD SRYD+
Sbjct: 136 CGSGGPPIITK-PERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDF 194
Query: 187 FARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRN-ICIATAE 245
F+R VP D YQA+AM +I+R W YVSTVASEG YGE+G+EAF Q++R +CIA +
Sbjct: 195 FSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSV 254
Query: 246 KVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANAS--FTWVASDGW 303
K+ R +D +IR LL+ NAR V++F DD R ++ AA RAN + F W+ SD W
Sbjct: 255 KIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSW 314
Query: 304 GAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL 363
G++ + + E VA GA+T+ VR FDRYF S NN RN WF +FWE F C L
Sbjct: 315 GSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKL 374
Query: 364 QN----KRNHRRVCDKHLAI-DSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKL 418
K +H + C I S YEQE K+ FV++AVYAM HALH M R LCP L
Sbjct: 375 SRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGL 434
Query: 419 CDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKY 478
C M +DG +L K Y+ +NF+ A + V F+ GD GRY+++ +Q
Sbjct: 435 CPRMDPVDGTQLLK-YIRNVNFSGI------AGNPVTFNENGDAPGRYDIYQYQLRNDSA 487
Query: 479 SYLKVGHWAETLSLDVNSIHW--SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEP 536
Y +G W + L L + +HW S +P S CS PC P E K G CCW C PC
Sbjct: 488 EYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTG 547
Query: 537 YEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVT 596
Y+Y D +TC C PT + TGC +P + W WA+ P+ +A +G T VV
Sbjct: 548 YQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVI 607
Query: 597 VFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICY 656
F+++N+TP+VKASGREL Y+LL G+ L Y TF IA+P C+LRR+ LG +I Y
Sbjct: 608 TFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISY 667
Query: 657 SALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGT-- 714
+ALLTKTN I RIF+ K P+FISP+SQ+ I LI +Q++ + VW +++ +
Sbjct: 668 AALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVV 727
Query: 715 ---RRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFI 771
+ TL + +LKC++ D S++ L Y ++L++ CTVYA KTR PE FNEAK I
Sbjct: 728 DFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPI 787
Query: 772 GFTMYTTCIIWLAFLPIFYVTSSD---YRVQTTTMCISVSLSGFVVLGCLFAPKVHIILF 828
GFTMYTTCI+WLAF+PIF+ TS +QTTT+ +SVSLS V LG L+ PKV+IILF
Sbjct: 788 GFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILF 847
Query: 829 QPQKNVVTHRLHLNRFSVSGT 849
P++NV + L + T
Sbjct: 848 HPEQNVPKRKRSLKAVVTAAT 868
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 674 bits (1738), Expect = 0.0
Identities = 376/868 (43%), Positives = 530/868 (61%), Gaps = 48/868 (5%)
Query: 37 GDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92
GD+++G LF ++ + T + +CG + E GIQR+EAML ++ IN D LLP + LG
Sbjct: 33 GDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLG 92
Query: 93 VHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM--CPDGSYA-IQENIPLLIAGVIGGS 149
I D+C ALEQS+EF+R SL +E E + C DGS + + P I GVIG
Sbjct: 93 CEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKP--IVGVIGPG 150
Query: 150 YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFN 209
SSV+IQV NLL+LF IPQI+Y++TS LSDK+ + YF R VP D QA+AM +I++ +N
Sbjct: 151 SSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYN 210
Query: 210 WTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQK-PN 268
WTYVS V +EG+YGE+G+EAF+ + ICIA + K+ + +S+D ++++L P
Sbjct: 211 WTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPK 270
Query: 269 ARVVVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELA 326
ARVV F R L+ A R + F + SDGW + + G + A G IT++L
Sbjct: 271 ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQ 330
Query: 327 SQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL----QNKRNHRRVCDKHLAIDSS 382
S V+ FD Y+ L P NHRNPWF++FW+ +FQC L Q + + C+ L + +
Sbjct: 331 SPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTL-KT 389
Query: 383 NYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTA 442
++ Q+SK+ FV+NA+Y+MA+ LH MQ +LCP LCDAMK +DG+KL + L+K NFT
Sbjct: 390 HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLES-LMKTNFTG 448
Query: 443 PFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKY-SYLKVGHWAE-TLSLDVNSIHWS 500
D+I+ FD GD GRY + NF+ +G Y Y+ VG W L +D + +
Sbjct: 449 V-----SGDTIL-FDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSK 502
Query: 501 RNSVPTSQCSDPCAPNEMKNMQPGDV-CCWICIPCEPYEYLADEFTCMDCGSGQWPTADL 559
++++ S CS+PC ++K ++ G+V CCW C PC+ EY+ DE+TC C G WPT DL
Sbjct: 503 KSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDL 562
Query: 560 TGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILL 619
TGC +P Y+RW D I V ACLG + T V VFI + +TP+VK+S RELCYI+L
Sbjct: 563 TGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIIL 622
Query: 620 FGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNG--A 677
G+ L Y TF IAKP + C L+R+G+G S A+ YSAL+TKTN IARI G K
Sbjct: 623 AGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICT 682
Query: 678 QRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSM 737
++P+F+S +Q+ I LI +Q+ ++ I+E P + RE V L CN + +
Sbjct: 683 KKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDI-MHDYPSIRE-VYLICNTTNLGV 740
Query: 738 LISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYR 797
+ L Y+ +L++ CT YAFKTR P NFNEAK+I FTMYTTCIIWLAF+PI++ S+Y+
Sbjct: 741 VTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--GSNYK 798
Query: 798 VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV-------VTHRLHLNRFSVSGTG 850
+ TMC SVSLS V LGC+F PKV+IIL +P++NV R+H+ G G
Sbjct: 799 I--ITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHV------GDG 850
Query: 851 TTYSQSSASTYVPTVCNGREVLDSTTSS 878
+ S +S S+ + + R T SS
Sbjct: 851 KSSSAASRSSSLVNLWKRRGSSGETLSS 878
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 672 bits (1735), Expect = 0.0
Identities = 365/817 (44%), Positives = 512/817 (62%), Gaps = 35/817 (4%)
Query: 37 GDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92
GD+++G LF ++ + T + +CG + E GIQR+EAML ++ IN D LLP + LG
Sbjct: 33 GDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLG 92
Query: 93 VHILDTCSRDTYALEQSLEFVRASLTKVDEAEYM--CPDGSYA-IQENIPLLIAGVIGGS 149
I D+C ALEQS+EF+R SL +E E + C DGS + + P I GVIG
Sbjct: 93 CEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKP--IVGVIGPG 150
Query: 150 YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFN 209
SSV+IQV NLL+LF IPQI+Y++TS LSDK+ + YF R VP D QA+AM +I++ +N
Sbjct: 151 SSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYN 210
Query: 210 WTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQK-PN 268
WTYVS V +EG+YGE+G+EAF+ + ICIA + K+ + +S+D ++++L P
Sbjct: 211 WTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPK 270
Query: 269 ARVVVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELA 326
ARVV F R L+ A R + F + SDGW + + G + A G IT++L
Sbjct: 271 ARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQ 330
Query: 327 SQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL----QNKRNHRRVCDKHLAIDSS 382
S V+ FD Y+ L P NHRNPWF++FW+ +FQC L Q + + C+ L + +
Sbjct: 331 SPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTL-KT 389
Query: 383 NYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTA 442
++ Q+SK+ FV+NA+Y+MA+ LH MQ +LCP LCDAMK +DG+KL + L+K NFT
Sbjct: 390 HHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLES-LMKTNFTG 448
Query: 443 PFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKY-SYLKVGHWAE-TLSLDVNSIHWS 500
D+I+ FD GD GRY + NF+ +G Y Y+ VG W L +D + +
Sbjct: 449 V-----SGDTIL-FDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSK 502
Query: 501 RNSVPTSQCSDPCAPNEMKNMQPGDV-CCWICIPCEPYEYLADEFTCMDCGSGQWPTADL 559
++++ S CS+PC ++K ++ G+V CCW C PC+ EY+ DE+TC C G WPT DL
Sbjct: 503 KSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDL 562
Query: 560 TGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILL 619
TGC +P Y+RW D I V ACLG + T V VFI + +TP+VK+S RELCYI+L
Sbjct: 563 TGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIIL 622
Query: 620 FGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNG--A 677
G+ L Y TF IAKP + C L+R+G+G S A+ YSAL+TKTN IARI G K
Sbjct: 623 AGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICT 682
Query: 678 QRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSM 737
++P+F+S +Q+ I LI +Q+ ++ I+E P + RE V L CN + +
Sbjct: 683 KKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDI-MHDYPSIRE-VYLICNTTNLGV 740
Query: 738 LISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYR 797
+ L Y+ +L++ CT YAFKTR P NFNEAK+I FTMYTTCIIWLAF+PI++ S+Y+
Sbjct: 741 VTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--GSNYK 798
Query: 798 VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834
+ TMC SVSLS V LGC+F PKV+IIL +P++NV
Sbjct: 799 I--ITMCFSVSLSATVALGCMFVPKVYIILAKPERNV 833
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 668 bits (1724), Expect = 0.0
Identities = 367/839 (43%), Positives = 514/839 (61%), Gaps = 34/839 (4%)
Query: 16 SKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEA 71
S G + L + R +++GD+++G LF ++ + + +CG I E GIQR+EA
Sbjct: 22 SPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEA 81
Query: 72 MLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV----DEAEYMC 127
M +D+IN D LLP + LG I D+C + ALEQS+EF+R SL + D
Sbjct: 82 MFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCL 141
Query: 128 PDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYF 187
PDG IAGVIG SSV+IQV NLL+LF IPQI+Y++TS LSDK+ Y YF
Sbjct: 142 PDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYF 201
Query: 188 ARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKV 247
R VP D QA+AM +I++ +NWTYVS V +EG+YGE+G++AF++ A +CIA ++K+
Sbjct: 202 LRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKI 261
Query: 248 GRSNIRKSYDSVIRELLQK-PNARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWG 304
+ KS+D ++R+L ++ P ARVVV F R L++A R F+ + SDGW
Sbjct: 262 YSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWA 321
Query: 305 AQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQ 364
++ +I+G E A G IT++L S VR FD YF L N RNPWF +FW+ +FQC L
Sbjct: 322 DRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLP 381
Query: 365 N----KRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD 420
N +R+C + +++ NY Q+SK+ FV+NA+YAMAH L M LCP LCD
Sbjct: 382 GHLLENPNFKRICTGNESLEE-NYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCD 440
Query: 421 AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNV-GGKYS 479
AMK +DG KL D+L+K +F V FD GD GRY++ N Q +Y
Sbjct: 441 AMKPIDGSKLL-DFLIKSSFIGVSGEE------VWFDEKGDAPGRYDIMNLQYTEANRYD 493
Query: 480 YLKVGHWAE-TLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDV-CCWICIPCEPY 537
Y+ VG W E L++D I +++ V S CS+PC ++K ++ G+V CCWIC C+
Sbjct: 494 YVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKEN 553
Query: 538 EYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTV 597
EY+ DEFTC C G WP ADLTGC +P Y+ W + +I + +CLG + T V +
Sbjct: 554 EYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLI 613
Query: 598 FIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYS 657
F+ + +TP+VK+S RELCYI+L G+ L Y F IAKP+ C L+RL +G S A+CYS
Sbjct: 614 FVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYS 673
Query: 658 ALLTKTNCIARIFDGVKNG--AQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTR 715
AL+TKTN IARI G K ++P+F+S +QV I LI VQ+ +V +I+E P
Sbjct: 674 ALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPP--M 731
Query: 716 RYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM 775
+ V L CN + ++ L Y+ +L++ CT YAFKTR P NFNEAK+I FTM
Sbjct: 732 PILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTM 791
Query: 776 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834
YTTCIIWLAF+PI++ S+Y++ TT C +VSLS V LGC+F PK++II+ +P++NV
Sbjct: 792 YTTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 668 bits (1724), Expect = 0.0
Identities = 367/839 (43%), Positives = 514/839 (61%), Gaps = 34/839 (4%)
Query: 16 SKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEA 71
S G + L + R +++GD+++G LF ++ + + +CG I E GIQR+EA
Sbjct: 22 SPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEA 81
Query: 72 MLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV----DEAEYMC 127
M +D+IN D LLP + LG I D+C + ALEQS+EF+R SL + D
Sbjct: 82 MFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCL 141
Query: 128 PDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYF 187
PDG IAGVIG SSV+IQV NLL+LF IPQI+Y++TS LSDK+ Y YF
Sbjct: 142 PDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYF 201
Query: 188 ARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKV 247
R VP D QA+AM +I++ +NWTYVS V +EG+YGE+G++AF++ A +CIA ++K+
Sbjct: 202 LRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKI 261
Query: 248 GRSNIRKSYDSVIRELLQK-PNARVVVLFMRSDDSRELIAAASRANA--SFTWVASDGWG 304
+ KS+D ++R+L ++ P ARVVV F R L++A R F+ + SDGW
Sbjct: 262 YSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWA 321
Query: 305 AQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQ 364
++ +I+G E A G IT++L S VR FD YF L N RNPWF +FW+ +FQC L
Sbjct: 322 DRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLP 381
Query: 365 N----KRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD 420
N +R+C + +++ NY Q+SK+ FV+NA+YAMAH L M LCP LCD
Sbjct: 382 GHLLENPNFKRICTGNESLEE-NYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCD 440
Query: 421 AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNV-GGKYS 479
AMK +DG KL D+L+K +F V FD GD GRY++ N Q +Y
Sbjct: 441 AMKPIDGSKLL-DFLIKSSFIGVSGEE------VWFDEKGDAPGRYDIMNLQYTEANRYD 493
Query: 480 YLKVGHWAE-TLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDV-CCWICIPCEPY 537
Y+ VG W E L++D I +++ V S CS+PC ++K ++ G+V CCWIC C+
Sbjct: 494 YVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKEN 553
Query: 538 EYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTV 597
EY+ DEFTC C G WP ADLTGC +P Y+ W + +I + +CLG + T V +
Sbjct: 554 EYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLI 613
Query: 598 FIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYS 657
F+ + +TP+VK+S RELCYI+L G+ L Y F IAKP+ C L+RL +G S A+CYS
Sbjct: 614 FVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYS 673
Query: 658 ALLTKTNCIARIFDGVKNG--AQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTR 715
AL+TKTN IARI G K ++P+F+S +QV I LI VQ+ +V +I+E P
Sbjct: 674 ALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPP--M 731
Query: 716 RYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM 775
+ V L CN + ++ L Y+ +L++ CT YAFKTR P NFNEAK+I FTM
Sbjct: 732 PILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTM 791
Query: 776 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834
YTTCIIWLAF+PI++ S+Y++ TT C +VSLS V LGC+F PK++II+ +P++NV
Sbjct: 792 YTTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTVALGCMFTPKMYIIIAKPERNV 846
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 419 bits (1076), Expect = e-117
Identities = 289/865 (33%), Positives = 436/865 (50%), Gaps = 89/865 (10%)
Query: 36 EGDLVLGGLFPIN----------EKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYL 85
+GD++LGGLFPI+ + + EC R N RG + L+AM+FAI+EIN L
Sbjct: 29 KGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNF-RGFRWLQAMIFAIEEINSSPAL 87
Query: 86 LPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGV 145
LP + LG I DTC+ + ALE +L FV + K+D D E+IP IA V
Sbjct: 88 LPNLTLGYRIFDTCNTVSKALEATLSFVAQN--KIDSLNL---DEFCNCSEHIPSTIA-V 141
Query: 146 IGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEIL 205
+G + S VS VANLL LF IPQ+SYAS+S LS+K+++ F RT+P D +QA AMA+I+
Sbjct: 142 VGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADII 201
Query: 206 RFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQ 265
+F W +V T+A++ DYG GIE F +EA R+ICI +E + + + + V+ E++Q
Sbjct: 202 EYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVV-EVIQ 260
Query: 266 KPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESIIKGSE--HVAYGAIT 322
A+V+V+F D LI R N W+AS+ W A S+I + HV G I
Sbjct: 261 NSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAW-ASSSLIAMPQYFHVVGGTIG 319
Query: 323 LELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQN-----------KRNH-- 369
L + + F + + ++P + N + ++FWE+ F C LQ R H
Sbjct: 320 FALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEE 379
Query: 370 ------------RRVC--DKHLAIDSSNYEQESKIMFVVN---AVYAMAHALHKMQRTLC 412
R +C D++++ + Y + + N AVY++AHAL + T
Sbjct: 380 SGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIY-TCL 438
Query: 413 PN----TTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNV 468
P T C +K ++ ++ K +L +NFT + V FD GD +G Y++
Sbjct: 439 PGRGLFTNGSCADIKKVEAWQVLK-HLRHLNFT------NNMGEQVTFDECGDLVGNYSI 491
Query: 469 FN-----------FQNVGGKYSYLKVGHWAETLSLDVNSIHWS--RNSVPTSQCSDPCAP 515
N F+ VG Y K G E L ++ I WS VP S CS C
Sbjct: 492 INWHLSPEDGSIVFKEVGYYNVYAKKG---ERLFINEEKILWSGFSREVPFSNCSRDCLA 548
Query: 516 NEMKNMQPGD-VCCWICIPCEPYEYL--ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRW 572
K + G+ CC+ C+ C EY D C C W + T C +++ W
Sbjct: 549 GTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSW 608
Query: 573 EDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFF 632
+ + I A LG T V+ VFIK NTP+VKA+ REL Y+LLF + + + FF
Sbjct: 609 TEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFF 668
Query: 633 IAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFIC 692
I +P C LR+ G SF +C S +L KTN + +F+ + K+ + Q +
Sbjct: 669 IGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLV 728
Query: 693 LGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLIS--LTYDVILVIL 750
+QIV+ +WL P + R E E + + C+ + S M + + Y +L +
Sbjct: 729 FLCTFMQIVICVIWLYTAPPSSYRNQELED-EIIFITCH-EGSLMALGFLIGYTCLLAAI 786
Query: 751 CTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLS 810
C +AFK+RK PENFNEAKFI F+M I+W++F+P + T + + I++ +
Sbjct: 787 CFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF--VSAVEVIAILAA 844
Query: 811 GFVVLGCLFAPKVHIILFQPQKNVV 835
F +L C+F K++IILF+P +N +
Sbjct: 845 SFGLLACIFFNKIYIILFKPSRNTI 869
>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
sapiens]
Length = 254
Score = 375 bits (964), Expect = e-104
Identities = 183/254 (72%), Positives = 215/254 (84%), Gaps = 2/254 (0%)
Query: 628 MTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSS 687
MTF FIAKPS +C LRRLGLG++F++CYSALLTKTN IARIF G + GAQRP+FISP+S
Sbjct: 1 MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS 60
Query: 688 QVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVIL 747
QV ICL LI Q+++V WL++EAPGT + T E+RE V L+CN +D+SML SL Y+V+L
Sbjct: 61 QVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLL 120
Query: 748 VILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISV 807
+ LCT+YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC+SV
Sbjct: 121 IALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 180
Query: 808 SLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRF--SVSGTGTTYSQSSASTYVPTV 865
SLSG VVLGCLFAPK+HIILFQPQKNVV+HR +RF + + ++ Q S S +VPTV
Sbjct: 181 SLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTV 240
Query: 866 CNGREVLDSTTSSL 879
CNGREV+DSTTSSL
Sbjct: 241 CNGREVVDSTTSSL 254
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 300 bits (769), Expect = 3e-81
Identities = 232/849 (27%), Positives = 391/849 (46%), Gaps = 90/849 (10%)
Query: 37 GDLVLGGLFPINEKGTGTEECGR---INEDRGIQ-----RLEAMLFAIDEINKDDYLLPG 88
G +++GGLF I+EK +E+ R I E G + + AM+ +I+ IN LLPG
Sbjct: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNST-LLPG 92
Query: 89 VKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGG 148
VKLG I DTC+ T A+ +L F+ + E+ C SY + + VIG
Sbjct: 93 VKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR------VKAVIGS 146
Query: 149 SYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFF 208
YS +++ V+ +L L +PQ+ Y ST+ LSDK R+ F RTVP DF+Q KAMA +++
Sbjct: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206
Query: 209 NWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKV----GRSNIRKSYDSVIRELL 264
W ++ + ++ DYG + F +A N+CIA E + + I + +++++
Sbjct: 207 GWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKII 266
Query: 265 QKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAIT-L 323
+ V+V+F+R +L A N + W+ASD W I G +
Sbjct: 267 LEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGF 326
Query: 324 ELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCS----------LQNKRNHRRVC 373
+ F + Q+L+ + + ++ C+ + N
Sbjct: 327 AFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAY 386
Query: 374 DKHLAIDSS---------NYEQESKIMFVVNAVYAMAHALHKM-QRTLC--PNTTKLCDA 421
+ AI+ + +Y + I + AV+A+ +A+ + Q C PN + +
Sbjct: 387 KANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWEL 446
Query: 422 MKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYL 481
+ +L + FT +N FD GD Y+V ++ + G +
Sbjct: 447 LGVLKN----------VTFTDGWNS-------FHFDAHGDLNTGYDVVLWKEINGHMTVT 489
Query: 482 KVGHWAETLSLDVNSIHWSRNSVPT-----SQCSDPCAPNEMKNMQPGD-VCCWICIPCE 535
K+ + + + ++N S+CS C+P +MK +CC+ C C
Sbjct: 490 KMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCP 549
Query: 536 PYEYL--ADEFTCMDCGSG-QWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTC 592
Y D C+ C + W T C++ +Y+ W D+ AI + ++ LG +
Sbjct: 550 ENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVL 609
Query: 593 MVVTVFIKHNNTPLVKASGR-ELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSS 651
+V +F ++ NTP+VK+SG +CY++L L++ T FFI +P C R+ G S
Sbjct: 610 VVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVS 669
Query: 652 FAICYSALLTKTNCIARIFDGVKNGAQRPKFIS----PSSQVFICLGLILVQIVMVSVWL 707
F +C S +LTK+ +I + KF+ P +F C G +Q+V+ ++WL
Sbjct: 670 FTLCISCILTKS---LKILLAFSFDPKLQKFLKCLYRPILIIFTCTG---IQVVICTLWL 723
Query: 708 ILEAPGTRRYTLAEKRETVILKCNVKDSSML---ISLTYDVILVILCTVYAFKTRKCPEN 764
I AP T ++ R +IL+C ++ S+L L Y IL +C ++AFK + EN
Sbjct: 724 IFAAP-TVEVNVSLPR-VIILEC--EEGSILAFGTMLGYIAILAFICFIFAFKGKY--EN 777
Query: 765 FNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVH 824
+NEAKFI F M I W+ F+PI+ T Y I + +S + +L C F PK +
Sbjct: 778 YNEAKFITFGMLIYFIAWITFIPIYATTFGKY--VPAVEIIVILISNYGILYCTFIPKCY 835
Query: 825 IILFQPQKN 833
+I+ + + N
Sbjct: 836 VIICKQEIN 844
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 247 bits (631), Expect = 3e-65
Identities = 211/837 (25%), Positives = 360/837 (43%), Gaps = 81/837 (9%)
Query: 35 IEGDLVLGGLFPINEKGTGTEECGRINEDR---------GIQRLEAMLFAIDEINKDDYL 85
+ GD +LGGLF ++ G + G ++AM FA++EIN D L
Sbjct: 29 LPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSL 88
Query: 86 LPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGV 145
LPGV LG I+D C + +++ V L D + D S I + V
Sbjct: 89 LPGVLLGYEIVDVCY-----ISNNVQPVLYFLAHEDNLLPIQEDYSNYISR-----VVAV 138
Query: 146 IGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEIL 205
IG S + VAN L LF +PQI+Y++ S +L DK R+ RT P + +AM +++
Sbjct: 139 IGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLM 198
Query: 206 RFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDS------- 258
F W ++ + S YG + + R+ICIA E + ++ S
Sbjct: 199 LHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLV 258
Query: 259 VIRELLQKPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESIIKGSEHVA 317
I + LQ+ ARVVV+F R N W+AS+ W + +E
Sbjct: 259 TIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRH 318
Query: 318 YGA-ITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKH 376
G + + + S P+ F + + + P Q + C+ + CD
Sbjct: 319 LGTFLGITIQSVPIPGFSEFRE----WGPQAGPPPLSRTSQSYTCNQE--------CDNC 366
Query: 377 LAIDSS-----NYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLY 431
L S E + V +AVYA+AHALH + C +T C + + L
Sbjct: 367 LNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLG--CDKST--CTKRVVYPWQLL- 421
Query: 432 KDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHW----A 487
+ + K+NFT D + FD GD + +Q + + V +
Sbjct: 422 -EEIWKVNFTL-------LDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQR 473
Query: 488 ETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL---ADEF 544
+ ++ S H N++P S CS C + K VCC+ CI C P +L DE+
Sbjct: 474 QLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEY 533
Query: 545 TCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNT 604
C C + +W T C+ ++ W +A I +A LGF+ T ++ +F +H T
Sbjct: 534 ECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQT 593
Query: 605 PLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTN 664
P+V+++G +C+++L + ++Y + ++ P C R+ F IC S + ++
Sbjct: 594 PIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSF 653
Query: 665 CIARIFDGVKNGAQRPKFISPSSQVFICLGLILV-QIVMVSVWLILEAPGTRRYTLAEKR 723
I F + + ++ + I V ++V+V + ++ T +
Sbjct: 654 QIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDP 713
Query: 724 ETVILKCNVK-DSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM---YTTC 779
+ I+ CN +S+L + + D++L ++ +A+ ++ P N+NEAKFI +M +T+
Sbjct: 714 KITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSS 773
Query: 780 IIWLAFLPIF---YVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKN 833
+ F+ + VT D V T +++SL F PK ++ILF P++N
Sbjct: 774 VSLCTFMSAYSGVLVTIVDLLV-TVLNLLAISLG-------YFGPKCYMILFYPERN 822
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 229 bits (585), Expect = 6e-60
Identities = 219/859 (25%), Positives = 358/859 (41%), Gaps = 116/859 (13%)
Query: 32 EIKIEGDLVLGGLFPINE---------KGTGTEECGRINEDRGIQRLEAMLFAIDEINKD 82
+ + GD +L GLFP++ + T + NE G +AM ++EIN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNE-HGYHLFQAMRLGVEEINNS 89
Query: 83 DYLLPGVKLGVHILDTCS--RDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPL 140
LLP + LG + D CS + YA + L G + I+ L
Sbjct: 90 TALLPNITLGYQLYDVCSDSANVYATLRVLSL----------------PGQHHIELQGDL 133
Query: 141 L-----IAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDF 195
L + VIG ++ + A LL F +P ISYA++S LS K +Y F RT+P D
Sbjct: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
Query: 196 YQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRS-NIRK 254
YQ + M +L+ F WT++S V S DYG+ G++A E +A + ICIA + + S +
Sbjct: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGD 253
Query: 255 SYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESI--IK 311
+ L + A VVV+F +R + N WVAS+ W I +
Sbjct: 254 ERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVP 313
Query: 312 GSEHV--AYGAITLELASQPVRQFDRYFQSLN---PYNNHRNPWFRDFWEQKFQCSLQNK 366
G + + G + A ++ F+ + + P H+ W CS
Sbjct: 314 GIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSW----------CS---S 360
Query: 367 RNHRRVCDKHLAIDSSNYE--QESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKI 424
R C +A + S AVYA+AH LH+ L + C ++
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQ----LLGCASGACSRGRV 416
Query: 425 LDG---KKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYL 481
++++K + L T FN N+D + YN+ + G K+++
Sbjct: 417 YPWQLLEQIHKVHFLLHKDTVAFNDNRDP------------LSSYNIIAWDWNGPKWTFT 464
Query: 482 KVGH--WAET-LSLDVNSIHW--SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEP 536
+G W+ L+++ I W N VP S CS C + + CC+ C+PC
Sbjct: 465 VLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGA 524
Query: 537 YEYL--ADEFTCMDCGSGQWPTADLTGCYDLPEDY--IRWEDAWAIGPVTIACLGFMCTC 592
+L +D + C CG +W C+ + +R +W + + L +
Sbjct: 525 GTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL--LAANTLLLLLLL 582
Query: 593 MVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSF 652
+F H +TP+V+++G LC+++L + + F +P+ C LR+ F
Sbjct: 583 GTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGF 642
Query: 653 AICYSALLTKTNCIARIFD-----------GVKN-GAQRPKFISPSSQVFICLGLILVQI 700
I S L ++ + IF V+N GA IS ++Q+ ICL ++
Sbjct: 643 TIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLV--- 699
Query: 701 VMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDS-SMLISLTYDVILVILCTVYAFKTR 759
VW L A +R+ V+L+C +S +++ Y+ +L I ++ +
Sbjct: 700 ----VWTPLPAREYQRFP-----HLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGK 750
Query: 760 KCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC-ISVSLSGFVVLGCL 818
PEN+NEAK + F++ + W+AF V Y M +S SGF G
Sbjct: 751 DLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGF---GGY 807
Query: 819 FAPKVHIILFQPQKNVVTH 837
F PK ++IL +P N H
Sbjct: 808 FLPKCYVILCRPDLNSTEH 826
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 209 bits (532), Expect = 9e-54
Identities = 210/857 (24%), Positives = 361/857 (42%), Gaps = 61/857 (7%)
Query: 29 LRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDR------------GIQRLEAMLFAI 76
L ++++++GD VLGGLFP+ E EE G + R G+ AM A+
Sbjct: 25 LSQQLRMKGDYVLGGLFPLGE----AEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAV 80
Query: 77 DEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQE 136
+EIN LLPG++LG + DTCS A++ SL F+ + ++ D A Y C Y
Sbjct: 81 EEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSR-DIAAY-CNYTQYQ--- 135
Query: 137 NIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFY 196
P ++A VIG S +++ F +PQ+SY ++ LS + + F RTVP D
Sbjct: 136 --PRVLA-VIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRV 192
Query: 197 QAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSY 256
Q A AE+L+ F W +V+ + S+ +YG G+ F A R ICIA V S
Sbjct: 193 QLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSR 252
Query: 257 DSVIRELLQKPN---ARVVVLFMRSDDSRELI--AAASRANASFTWVASDGWGAQESIIK 311
++++L + N +VV+LF + L + +SR + WVAS+ W + ++
Sbjct: 253 LGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPK-VWVASEAWLTSDLVMG 311
Query: 312 GSEHVAYGAIT--LELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNH 369
G + L+ +Q + +F +Y ++ +P F ++ Q ++
Sbjct: 312 LPGMAQMGTVLGFLQRGAQ-LHEFPQYVKTHLALAT--DPAFCSALGEREQGLEEDVVGQ 368
Query: 370 R-RVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGK 428
R CD + S + V AVY++A ALH TL N + C A +
Sbjct: 369 RCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALH---NTLQCNASG-CPAQDPVKPW 424
Query: 429 KLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAE 488
+L ++ + + F P ++FD+ G+ Y++ + G VG +
Sbjct: 425 QLLEN-MYNLTFHVGGLP-------LRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNG 476
Query: 489 TLSLDVNSIHW--SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCE--PYEYLADEF 544
+L + I W S N P S+CS C +++ ++ CC+ C+ CE Y D+
Sbjct: 477 SLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDI 536
Query: 545 TCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNT 604
C CG +W T C+ ++ W + + + + L + +F+ H ++
Sbjct: 537 ACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDS 596
Query: 605 PLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTN 664
PLV+ASG L L +GL F +PSP C ++ C S L +
Sbjct: 597 PLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAA 656
Query: 665 CIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRE 724
I + + A R ++ + L ++ V + W ++ P
Sbjct: 657 EIFVESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPT 716
Query: 725 TVILKCNVKD-SSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWL 783
++ C + S ++ + L LC + F R P +N A+ + F M I W+
Sbjct: 717 EALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFITWV 776
Query: 784 AFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNR 843
+F+P+ R + + + G +L P+ ++++ QP N
Sbjct: 777 SFVPLLANVQVVLRPAVQMGALLLCVLG--ILAAFHLPRCYLLMRQPGLNTPEF------ 828
Query: 844 FSVSGTGTTYSQSSAST 860
F G G Q+ +T
Sbjct: 829 FLGGGPGDAQGQNDGNT 845
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 124 bits (310), Expect = 5e-28
Identities = 107/433 (24%), Positives = 185/433 (42%), Gaps = 52/433 (12%)
Query: 428 KKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGH-- 485
++++K + L T FN N+D + YN+ + G K+++ +G
Sbjct: 169 EQIHKVHFLLHKDTVAFNDNRDP------------LSSYNIIAWDWNGPKWTFTVLGSST 216
Query: 486 WAET-LSLDVNSIHW--SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL-- 540
W+ L+++ I W N VP S CS C + + CC+ C+PC +L
Sbjct: 217 WSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNK 276
Query: 541 ADEFTCMDCGSGQWPTADLTGCYDLPEDYI--RWEDAWAIGPVTIACLGFMCTCMVVTVF 598
+D + C CG +W C+ ++ R +W + + L + +F
Sbjct: 277 SDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVL--LAANTLLLLLLLGTAGLF 334
Query: 599 IKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSA 658
H +TP+V+++G LC+++L + + F +P+ C LR+ F I S
Sbjct: 335 AWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSC 394
Query: 659 LLTKTNCIARIFD-----------GVKN-GAQRPKFISPSSQVFICLGLILVQIVMVSVW 706
L ++ + IF V+N GA IS ++Q+ ICL ++ VW
Sbjct: 395 LTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLV-------VW 447
Query: 707 LILEAPGTRRYTLAEKRETVILKCNVKDS-SMLISLTYDVILVILCTVYAFKTRKCPENF 765
L A +R+ V+L+C +S +++ Y+ +L I ++ + PEN+
Sbjct: 448 TPLPAREYQRFP-----HLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENY 502
Query: 766 NEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMC-ISVSLSGFVVLGCLFAPKVH 824
NEAK + F++ + W+AF V Y M +S SGF G F PK +
Sbjct: 503 NEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGF---GGYFLPKCY 559
Query: 825 IILFQPQKNVVTH 837
+IL +P N H
Sbjct: 560 VILCRPDLNSTEH 572
Score = 40.4 bits (93), Expect = 0.007
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 10/78 (12%)
Query: 32 EIKIEGDLVLGGLFPINE---------KGTGTEECGRINEDRGIQRLEAMLFAIDEINKD 82
+ + GD +L GLFP++ + T + NE G +AM ++EIN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNE-HGYHLFQAMRLGVEEINNS 89
Query: 83 DYLLPGVKLGVHILDTCS 100
LLP + LG + D CS
Sbjct: 90 TALLPNITLGYQLYDVCS 107
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 121 bits (304), Expect = 2e-27
Identities = 110/403 (27%), Positives = 169/403 (41%), Gaps = 57/403 (14%)
Query: 32 EIKIEGDLVLGGLFPINE---------KGTGTEECGRINEDRGIQRLEAMLFAIDEINKD 82
+ + GD +L GLFP++ + T + NE G +AM ++EIN
Sbjct: 31 DFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNE-HGYHLFQAMRLGVEEINNS 89
Query: 83 DYLLPGVKLGVHILDTCS--RDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPL 140
LLP + LG + D CS + YA + L G + I+ L
Sbjct: 90 TALLPNITLGYQLYDVCSDSANVYATLRVLSL----------------PGQHHIELQGDL 133
Query: 141 L-----IAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDF 195
L + VIG ++ + A LL F +P ISYA++S LS K +Y F RT+P D
Sbjct: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193
Query: 196 YQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRS-NIRK 254
YQ + M +L+ F WT++S V S DYG+ G++A E +A + ICIA + + S +
Sbjct: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGD 253
Query: 255 SYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESI--IK 311
+ L + A VVV+F +R + N WVAS+ W I +
Sbjct: 254 ERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVP 313
Query: 312 GSEHV--AYGAITLELASQPVRQFDRYFQSLN---PYNNHRNPWFRDFWEQKFQCSLQNK 366
G + + G + A ++ F+ + + P H+ W CS
Sbjct: 314 GIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSW----------CS---S 360
Query: 367 RNHRRVCDKHLAIDSSNYE--QESKIMFVVNAVYAMAHALHKM 407
R C +A + S AVYA+AH LH++
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQL 403
>gi|7706451 G protein-coupled receptor, family C, group 5, member B
precursor [Homo sapiens]
Length = 403
Score = 66.2 bits (160), Expect = 1e-10
Identities = 66/281 (23%), Positives = 128/281 (45%), Gaps = 34/281 (12%)
Query: 561 GC-YDLPEDYIRWEDA---WAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRE--- 613
GC DL Y+ D W I +A G + T +++ + + P +K ++
Sbjct: 36 GCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVR--LPFIKEKEKKSPV 93
Query: 614 -LCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDG 672
L ++ L G + +TF FI + IC++RR G FA+C+S LL++ + R+
Sbjct: 94 GLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRL--- 150
Query: 673 VKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNV 732
V++G + V + L L+LVQ+++ WL+L L + R C
Sbjct: 151 VRHGTGPAGW----QLVGLALCLMLVQVIIAVEWLVLT-------VLRDTRPA----CAY 195
Query: 733 KDSSMLISLTYDVILVILCTVYAFKT--RKCPENFNEAKFIGFTMYTTCIIWLAFLPIFY 790
+ +++L YD++L+++ A T K F+ T + + +IW+A++ ++
Sbjct: 196 EPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYL 255
Query: 791 VTSSDYRV----QTTTMCISVSLSGFVVLGCLFAPKVHIIL 827
+ + T+ I+++ SG+V + P++H L
Sbjct: 256 FGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTL 296
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 57.4 bits (137), Expect = 6e-08
Identities = 63/302 (20%), Positives = 123/302 (40%), Gaps = 28/302 (9%)
Query: 583 IACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFF-------IAK 635
+ LG + + IK+ N L+K S + +++ G LSY F F K
Sbjct: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547
Query: 636 PSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGL 695
+C +R L + + A+ KT + IF VK + K I + I G+
Sbjct: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVK---MKKKIIKDQKLLVIVGGM 604
Query: 696 ILVQIVMVSVWLILE--APGTRRYTLAEK---RETVI--LKCNVKDSSMLISL----TYD 744
+L+ + ++ W ++ +Y++ R+ I L + +++ M I L Y
Sbjct: 605 LLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYK 664
Query: 745 VILVILCTVYAFKTRKCP-ENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTM 803
+L++ A++TR N++K+IG ++Y I+ + + ++T VQ +
Sbjct: 665 GLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIV 724
Query: 804 CISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNR------FSVSGTGTTYSQSS 857
+ + + L +F PK+ + P R + S + T+ +Q+S
Sbjct: 725 ALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQAS 784
Query: 858 AS 859
S
Sbjct: 785 TS 786
Score = 54.7 bits (130), Expect = 4e-07
Identities = 27/75 (36%), Positives = 45/75 (60%)
Query: 145 VIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEI 204
V GG SV+ +A L+ + + Q+S+A+T+ L+DK +Y YF RTVP D A+ ++
Sbjct: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189
Query: 205 LRFFNWTYVSTVASE 219
L+ + W V T+ +
Sbjct: 190 LKHYQWKRVGTLTQD 204
>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
Length = 1215
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/314 (23%), Positives = 129/314 (41%), Gaps = 40/314 (12%)
Query: 542 DEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVT----- 596
+ + C+ C G AD + C+ + Y+R +A + F CM++
Sbjct: 388 EAYVCLPCREGCPFCADDSPCFVQEDKYLR-----------LAIISFQALCMLLDFVSML 436
Query: 597 VFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICY 656
V ++ASG L +LFG L Y +PS C L R FA Y
Sbjct: 437 VVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVY 496
Query: 657 SALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRR 716
+ K + + ++F + AQR +++ +V L +IL +V W ++ +
Sbjct: 497 GTVTLKLHRVLKVF--LSRTAQRIPYMT-GGRVMRMLAVIL----LVVFWFLIGWTSSVC 549
Query: 717 YTLAEKRETVILKCNVKDS---SMLISLTYDVI------LVILCTVY-AFKTRKCPENFN 766
L EK+ ++I + D +M + +D + L +L VY + R P F+
Sbjct: 550 QNL-EKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAFH 608
Query: 767 EAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCI----SVSLSGFVVLGCLFAPK 822
E +++ ++ II F I +V +S R+Q+ M + L+ V +G L PK
Sbjct: 609 EPRYMAVAVHNELIISAIFHTIRFVLAS--RLQSDWMLMLYFAHTHLTVTVTIGLLLIPK 666
Query: 823 VHIILFQPQKNVVT 836
P+ ++ T
Sbjct: 667 FSHSSNNPRDDIAT 680
>gi|93352554 GPR158-like 1 [Homo sapiens]
Length = 2367
Score = 53.5 bits (127), Expect = 8e-07
Identities = 66/302 (21%), Positives = 119/302 (39%), Gaps = 26/302 (8%)
Query: 546 CMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHN--N 603
C+ C G D T C E+A + +AC + +++ + +
Sbjct: 356 CLPCPEGCTSCMDATPCLV--------EEAAVLRAAVLACQACCMLAIFLSMLVSYRCRR 407
Query: 604 TPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKT 663
+ ASG L +LFG L Y F KPS C R FAI Y ++ K
Sbjct: 408 NKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAIVYGTIILKL 467
Query: 664 NCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIV-MVSVWL-------ILEAPGTR 715
+ ++F + AQR +S S ++ LGL+L+ ++ ++VW I AP
Sbjct: 468 YRVLQLF--LSRTAQRSALLS-SGRLLRRLGLLLLPVLGFLAVWTVGALERGIQHAPLVI 524
Query: 716 RYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTM 775
R R + + D M+++ +++L+ + + TR F+E +++G +
Sbjct: 525 RGHTPSGRHFYLCHHDRWDYIMVVA---ELLLLCWGSFLCYATRAVLSAFHEPRYMGIAL 581
Query: 776 YTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFV--VLGCLFAPKVHIILFQPQKN 833
+ ++ AF +V T + V L +F PK + P++
Sbjct: 582 HNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKFWKLGAPPREE 641
Query: 834 VV 835
+V
Sbjct: 642 MV 643
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 51.2 bits (121), Expect = 4e-06
Identities = 34/141 (24%), Positives = 67/141 (47%), Gaps = 6/141 (4%)
Query: 164 FQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYG 223
++IP + + + SDKS + F RTVPP +Q+ E++R ++W ++ + S+ G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 224 ETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRE 283
+ E R + AEKV + + + + ++ ARV++L DD+
Sbjct: 174 RAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAAT 230
Query: 284 LIAAASRAN---ASFTWVASD 301
+ AA+ N + + W+ +
Sbjct: 231 VYRAAAMLNMTGSGYVWLVGE 251
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 51.2 bits (121), Expect = 4e-06
Identities = 34/141 (24%), Positives = 67/141 (47%), Gaps = 6/141 (4%)
Query: 164 FQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYG 223
++IP + + + SDKS + F RTVPP +Q+ E++R ++W ++ + S+ G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 224 ETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRE 283
+ E R + AEKV + + + + ++ ARV++L DD+
Sbjct: 174 RAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAAT 230
Query: 284 LIAAASRAN---ASFTWVASD 301
+ AA+ N + + W+ +
Sbjct: 231 VYRAAAMLNMTGSGYVWLVGE 251
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 51.2 bits (121), Expect = 4e-06
Identities = 34/141 (24%), Positives = 67/141 (47%), Gaps = 6/141 (4%)
Query: 164 FQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYG 223
++IP + + + SDKS + F RTVPP +Q+ E++R ++W ++ + S+ G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173
Query: 224 ETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRE 283
+ E R + AEKV + + + + ++ ARV++L DD+
Sbjct: 174 RAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAAT 230
Query: 284 LIAAASRAN---ASFTWVASD 301
+ AA+ N + + W+ +
Sbjct: 231 VYRAAAMLNMTGSGYVWLVGE 251
>gi|4506403 G protein-coupled receptor, family C, group 5, member A
[Homo sapiens]
Length = 357
Score = 46.6 bits (109), Expect = 1e-04
Identities = 57/266 (21%), Positives = 110/266 (41%), Gaps = 29/266 (10%)
Query: 574 DAWAIGPVTIACLG------FMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYC 627
+AW I T+A G FM T ++ ++ +N + + ++ L GV +
Sbjct: 25 EAWGIVLETVATAGVVTSVAFMLTLPILVCKVQDSNRRKMLPTQ----FLFLLGVLGIFG 80
Query: 628 MTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSS 687
+TF FI R G F+IC+S LL + ++ G K +S
Sbjct: 81 LTFAFIIGLDGSTGPTRFFLFGILFSICFSCLLAHAVSLTKLVRGRKP-------LSLLV 133
Query: 688 QVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVIL 747
+ + +G LVQ V+ +++L T +E L ++ ++ LTY +L
Sbjct: 134 ILGLAVGFSLVQDVIAIEYIVLTMNRTNVNVFSE------LSAPRRNEDFVLLLTY--VL 185
Query: 748 VILCTVYAFKTRKCPENFNEAKFIG----FTMYTTCIIWLAFLPIFYVTSSDYRVQTTTM 803
++ + + +F K G TM + IW+A++ + + D R T +
Sbjct: 186 FLMALTFLMSSFTFCGSFTGWKRHGAHIYLTMLLSIAIWVAWITLLMLPDFDRRWDDTIL 245
Query: 804 CISVSLSGFVVLGCLFAPKVHIILFQ 829
+++ +G+V L +P+ ++ Q
Sbjct: 246 SSALAANGWVFLLAYVSPEFWLLTKQ 271
>gi|40217833 G protein-coupled receptor family C, group 5, member C
isoform b [Homo sapiens]
Length = 453
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/271 (22%), Positives = 114/271 (42%), Gaps = 40/271 (14%)
Query: 575 AWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELC-----YILLFGVGLSYCMT 629
AW I +A G + T ++ + + + P V+ + + + LL +GL +C+
Sbjct: 60 AWGIVLEAVAGAGIVTTFVLTIILVA--SLPFVQDTKKRSLLGTQVFFLLGTLGL-FCLV 116
Query: 630 FFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQV 689
F + KP CA RR G FAIC+S L + A F KN R I
Sbjct: 117 FACVVKPDFSTCASRRFLFGVLFAICFSCL--AAHVFALNFLARKNHGPRGWVI-----F 169
Query: 690 FICLGLILVQIVMVSVWLIL-----EAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYD 744
+ L L LV++++ + WLI+ G + + V C + + +++L Y
Sbjct: 170 TVALLLTLVEVIINTEWLIITLVRGSGEGGPQGN-SSAGWAVASPCAIANMDFVMALIYV 228
Query: 745 VILVI---------LCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD 795
++L++ LC Y + RK F+ T T+ IW+ ++ ++ +
Sbjct: 229 MLLLLGAFLGAWPALCGRYK-RWRK------HGVFVLLTTATSVAIWVVWIVMYTYGNKQ 281
Query: 796 YRVQT---TTMCISVSLSGFVVLGCLFAPKV 823
+ T T+ I+++ + + + P+V
Sbjct: 282 HNSPTWDDPTLAIALAANAWAFVLFYVIPEV 312
>gi|40217831 G protein-coupled receptor family C, group 5, member C
isoform a [Homo sapiens]
Length = 486
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/271 (22%), Positives = 114/271 (42%), Gaps = 40/271 (14%)
Query: 575 AWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELC-----YILLFGVGLSYCMT 629
AW I +A G + T ++ + + + P V+ + + + LL +GL +C+
Sbjct: 93 AWGIVLEAVAGAGIVTTFVLTIILVA--SLPFVQDTKKRSLLGTQVFFLLGTLGL-FCLV 149
Query: 630 FFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQV 689
F + KP CA RR G FAIC+S L + A F KN R I
Sbjct: 150 FACVVKPDFSTCASRRFLFGVLFAICFSCL--AAHVFALNFLARKNHGPRGWVI-----F 202
Query: 690 FICLGLILVQIVMVSVWLIL-----EAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYD 744
+ L L LV++++ + WLI+ G + + V C + + +++L Y
Sbjct: 203 TVALLLTLVEVIINTEWLIITLVRGSGEGGPQGN-SSAGWAVASPCAIANMDFVMALIYV 261
Query: 745 VILVI---------LCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD 795
++L++ LC Y + RK F+ T T+ IW+ ++ ++ +
Sbjct: 262 MLLLLGAFLGAWPALCGRYK-RWRK------HGVFVLLTTATSVAIWVVWIVMYTYGNKQ 314
Query: 796 YRVQT---TTMCISVSLSGFVVLGCLFAPKV 823
+ T T+ I+++ + + + P+V
Sbjct: 315 HNSPTWDDPTLAIALAANAWAFVLFYVIPEV 345
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,768,136
Number of Sequences: 37866
Number of extensions: 1388774
Number of successful extensions: 3923
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3722
Number of HSP's gapped (non-prelim): 55
length of query: 879
length of database: 18,247,518
effective HSP length: 111
effective length of query: 768
effective length of database: 14,044,392
effective search space: 10786093056
effective search space used: 10786093056
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.