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Search of human proteins with 45827778
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45827778 reticulon 1 isoform B [Homo sapiens]
(356 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45827778 reticulon 1 isoform B [Homo sapiens] 701 0.0
gi|10863935 reticulon 1 isoform A [Homo sapiens] 701 0.0
gi|45827776 reticulon 1 isoform C [Homo sapiens] 364 e-101
gi|24431933 reticulon 4 isoform B [Homo sapiens] 287 1e-77
gi|47519490 reticulon 4 isoform D [Homo sapiens] 282 4e-76
gi|5902016 reticulon 4 isoform C [Homo sapiens] 271 9e-73
gi|47519562 reticulon 4 isoform E [Homo sapiens] 270 1e-72
gi|24431935 reticulon 4 isoform A [Homo sapiens] 270 1e-72
gi|5174655 reticulon 3 isoform a [Homo sapiens] 238 8e-63
gi|41393604 reticulon 3 isoform c [Homo sapiens] 235 4e-62
gi|41393608 reticulon 3 isoform b [Homo sapiens] 233 2e-61
gi|46255005 reticulon 2 isoform B [Homo sapiens] 211 1e-54
gi|41393606 reticulon 3 isoform d [Homo sapiens] 204 8e-53
gi|5032055 reticulon 2 isoform A [Homo sapiens] 197 1e-50
gi|46255007 reticulon 2 isoform C [Homo sapiens] 197 1e-50
gi|114155127 regulator of G-protein signalling 3 isoform 6 [Homo... 43 4e-04
gi|10864075 regulator of G-protein signalling 3 isoform 2 [Homo ... 43 4e-04
gi|62865651 regulator of G-protein signalling 3 isoform 1 [Homo ... 43 4e-04
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 42 6e-04
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 42 6e-04
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 42 6e-04
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 42 6e-04
gi|33286446 opioid growth factor receptor [Homo sapiens] 42 8e-04
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 42 0.001
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 41 0.001
gi|119829187 alpha 1 type XVII collagen [Homo sapiens] 41 0.002
gi|210032580 SET domain containing 1B [Homo sapiens] 41 0.002
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 40 0.002
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 40 0.002
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 40 0.002
>gi|45827778 reticulon 1 isoform B [Homo sapiens]
Length = 356
Score = 701 bits (1808), Expect = 0.0
Identities = 356/356 (100%), Positives = 356/356 (100%)
Query: 1 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 60
MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES
Sbjct: 1 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 60
Query: 61 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 120
PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD
Sbjct: 61 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 120
Query: 121 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 180
GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ
Sbjct: 121 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 180
Query: 181 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 240
TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY
Sbjct: 181 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 240
Query: 241 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 300
LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN
Sbjct: 241 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 300
Query: 301 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 356
GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
Sbjct: 301 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 356
>gi|10863935 reticulon 1 isoform A [Homo sapiens]
Length = 776
Score = 701 bits (1808), Expect = 0.0
Identities = 356/356 (100%), Positives = 356/356 (100%)
Query: 1 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 60
MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES
Sbjct: 421 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 480
Query: 61 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 120
PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD
Sbjct: 481 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 540
Query: 121 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 180
GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ
Sbjct: 541 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 600
Query: 181 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 240
TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY
Sbjct: 601 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 660
Query: 241 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 300
LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN
Sbjct: 661 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 720
Query: 301 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 356
GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
Sbjct: 721 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
>gi|45827776 reticulon 1 isoform C [Homo sapiens]
Length = 208
Score = 364 bits (935), Expect = e-101
Identities = 189/191 (98%), Positives = 190/191 (99%)
Query: 166 KQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 225
K +AIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL
Sbjct: 18 KSQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 77
Query: 226 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 285
QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF
Sbjct: 78 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 137
Query: 286 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 345
AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ
Sbjct: 138 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 197
Query: 346 AKIPGAKRHAE 356
AKIPGAKRHAE
Sbjct: 198 AKIPGAKRHAE 208
>gi|24431933 reticulon 4 isoform B [Homo sapiens]
Length = 373
Score = 287 bits (734), Expect = 1e-77
Identities = 171/361 (47%), Positives = 218/361 (60%), Gaps = 28/361 (7%)
Query: 21 PPSPASPSIQYSILRE----EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD 76
PP P P+ +Y +RE E E E + E E + E P + P+ P+A
Sbjct: 16 PPRP-QPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPV-PTAPA 73
Query: 77 AIREETGVRAEERAPSRRG---LAEPGSFLDYPSTEPQPGPELPPGDGAL---------- 123
A + P+ RG A P + PS +P P P L
Sbjct: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKL 133
Query: 124 --EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKA------IDLLYW 175
+ E P P P S S Q+ P P P APP K++ +DLLYW
Sbjct: 134 PEDDEPPARPPPPPPASVSPQAEPVWTPPAP-APAAPPSTPAAPKRRGSSGSVVVDLLYW 192
Query: 176 RDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGH 235
RDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGH
Sbjct: 193 RDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH 252
Query: 236 PFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYV 295
PF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYV
Sbjct: 253 PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYV 312
Query: 296 GALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHA 355
GALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR A
Sbjct: 313 GALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKA 372
Query: 356 E 356
E
Sbjct: 373 E 373
>gi|47519490 reticulon 4 isoform D [Homo sapiens]
Length = 392
Score = 282 bits (721), Expect = 4e-76
Identities = 163/341 (47%), Positives = 209/341 (61%), Gaps = 40/341 (11%)
Query: 21 PPSPASPSIQYSILREEREAELDSELIIESCDASS---ASEESPKR--EQDSPPMKPSAL 75
PP+P P + ER+ D + + A S A+ SP + E D PP +P
Sbjct: 87 PPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP- 145
Query: 76 DAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 135
S AEP T P P P PP TP P++
Sbjct: 146 ------------PPPASVSPQAEP------VWTPPAPAPAAPPS-------TPAAPKRRG 180
Query: 136 EDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSL 195
S +++ A P A P++ +DLLYWRDIK+TG+VFG+ L LL SL
Sbjct: 181 SSGSVDETLFAL-------PAASEPVI--RSSAVVDLLYWRDIKKTGVVFGASLFLLLSL 231
Query: 196 TQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKY 255
T FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGHPF+AYLE E+ +S+E +QKY
Sbjct: 232 TVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKY 291
Query: 256 TDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTL 315
++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYVGALFNGLTLL++A++S+F++
Sbjct: 292 SNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSV 351
Query: 316 PVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 356
PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR AE
Sbjct: 352 PVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 392
>gi|5902016 reticulon 4 isoform C [Homo sapiens]
Length = 199
Score = 271 bits (692), Expect = 9e-73
Identities = 130/191 (68%), Positives = 161/191 (84%)
Query: 166 KQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 225
K K +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+
Sbjct: 9 KDKVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI 68
Query: 226 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 285
QA+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKF
Sbjct: 69 QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKF 128
Query: 286 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 345
AVLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQ
Sbjct: 129 AVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQ 188
Query: 346 AKIPGAKRHAE 356
AKIPG KR AE
Sbjct: 189 AKIPGLKRKAE 199
>gi|47519562 reticulon 4 isoform E [Homo sapiens]
Length = 986
Score = 270 bits (691), Expect = 1e-72
Identities = 130/193 (67%), Positives = 162/193 (83%)
Query: 164 LNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKS 223
L+K +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK
Sbjct: 794 LSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKG 853
Query: 224 VLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSL 283
V+QA+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSL
Sbjct: 854 VIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSL 913
Query: 284 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAK 343
KFAVLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AK
Sbjct: 914 KFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAK 973
Query: 344 IQAKIPGAKRHAE 356
IQAKIPG KR AE
Sbjct: 974 IQAKIPGLKRKAE 986
Score = 30.0 bits (66), Expect = 3.3
Identities = 34/139 (24%), Positives = 55/139 (39%), Gaps = 17/139 (12%)
Query: 22 PSPASPSIQYSILREEREAELDSELIIESC---DASSASEESPKREQDSPPMKPSALD-A 77
PSP P I + +I S +ASS + ES K E ++PP A+ +
Sbjct: 401 PSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVS 460
Query: 78 IREETGVRAEERAPSRRGLAEPGSFLDYPS----------TEPQPGPELPPGDGALEPET 127
+++ +G++ E + P A + Y S +P P+ + E
Sbjct: 461 LKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQ 520
Query: 128 PMLPRKPE--EDSSSNQSP 144
P +P E EDSS + P
Sbjct: 521 P-VPDHSELVEDSSPDSEP 538
>gi|24431935 reticulon 4 isoform A [Homo sapiens]
Length = 1192
Score = 270 bits (691), Expect = 1e-72
Identities = 130/193 (67%), Positives = 162/193 (83%)
Query: 164 LNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKS 223
L+K +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK
Sbjct: 1000 LSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKG 1059
Query: 224 VLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSL 283
V+QA+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSL
Sbjct: 1060 VIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSL 1119
Query: 284 KFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAK 343
KFAVLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AK
Sbjct: 1120 KFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAK 1179
Query: 344 IQAKIPGAKRHAE 356
IQAKIPG KR AE
Sbjct: 1180 IQAKIPGLKRKAE 1192
Score = 32.0 bits (71), Expect = 0.87
Identities = 42/158 (26%), Positives = 56/158 (35%), Gaps = 22/158 (13%)
Query: 21 PPSPASPSIQYSILRE----EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD 76
PP P P+ +Y +RE E E E + E E + E P + P+ P+A
Sbjct: 16 PPRP-QPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPV-PTAPA 73
Query: 77 AIREETGVRAEERAPSRRG---LAEPGSFLDYPSTEPQPGPELPPGDGAL---------- 123
A + P+ RG A P + PS +P P P L
Sbjct: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKL 133
Query: 124 --EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPP 159
+ E P P P S S Q+ P P P APP
Sbjct: 134 PEDDEPPARPPPPPPASVSPQAEPVWTPPAP-APAAPP 170
Score = 30.0 bits (66), Expect = 3.3
Identities = 34/139 (24%), Positives = 55/139 (39%), Gaps = 17/139 (12%)
Query: 22 PSPASPSIQYSILREEREAELDSELIIESC---DASSASEESPKREQDSPPMKPSALD-A 77
PSP P I + +I S +ASS + ES K E ++PP A+ +
Sbjct: 607 PSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVS 666
Query: 78 IREETGVRAEERAPSRRGLAEPGSFLDYPS----------TEPQPGPELPPGDGALEPET 127
+++ +G++ E + P A + Y S +P P+ + E
Sbjct: 667 LKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQ 726
Query: 128 PMLPRKPE--EDSSSNQSP 144
P +P E EDSS + P
Sbjct: 727 P-VPDHSELVEDSSPDSEP 744
>gi|5174655 reticulon 3 isoform a [Homo sapiens]
Length = 236
Score = 238 bits (606), Expect = 8e-63
Identities = 123/223 (55%), Positives = 164/223 (73%), Gaps = 6/223 (2%)
Query: 138 SSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAI---DLLYWRDIKQTGIVFGSFLLLLFS 194
SS P+A G G PGA P L + + DL++WRD+K+TG VFG+ L++L S
Sbjct: 16 SSFGAEPSAPGGGG--SPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLS 73
Query: 195 LTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQK 254
L FSV+SVV+YL LA LS TISFRIYKSV+QAVQK++EGHPFKAYL+++ITLS E
Sbjct: 74 LAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHN 133
Query: 255 YTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFT 314
Y + ++N LK + RLFLV+DLVDSLK AV MWL+TYVGA+FNG+TLL++A + +F+
Sbjct: 134 YMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFS 193
Query: 315 LPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG-AKRHAE 356
+P+VY K++ QID Y+G+ R ++V KIQAK+PG AK+ AE
Sbjct: 194 VPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 236
>gi|41393604 reticulon 3 isoform c [Homo sapiens]
Length = 255
Score = 235 bits (600), Expect = 4e-62
Identities = 120/240 (50%), Positives = 166/240 (69%), Gaps = 10/240 (4%)
Query: 118 PGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRD 177
PG G P L K S ++ +++ P+ + + DL++WRD
Sbjct: 25 PGGGGSPGACPALGTKSCSSSCADSFVSSSSSQ---------PVSLFSTSQVHDLIFWRD 75
Query: 178 IKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPF 237
+K+TG VFG+ L++L SL FSV+SVV+YL LA LS TISFRIYKSV+QAVQK++EGHPF
Sbjct: 76 VKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPF 135
Query: 238 KAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGA 297
KAYL+++ITLS E Y + ++N LK + RLFLV+DLVDSLK AV MWL+TYVGA
Sbjct: 136 KAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGA 195
Query: 298 LFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG-AKRHAE 356
+FNG+TLL++A + +F++P+VY K++ QID Y+G+ R ++V KIQAK+PG AK+ AE
Sbjct: 196 VFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 255
>gi|41393608 reticulon 3 isoform b [Homo sapiens]
Length = 1013
Score = 233 bits (595), Expect = 2e-61
Identities = 112/187 (59%), Positives = 150/187 (80%), Gaps = 1/187 (0%)
Query: 171 DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQK 230
DL++WRD+K+TG VFG+ L++L SL FSV+SVV+YL LA LS TISFRIYKSV+QAVQK
Sbjct: 827 DLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQK 886
Query: 231 TDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMW 290
++EGHPFKAYL+++ITLS E Y + ++N LK + RLFLV+DLVDSLK AV MW
Sbjct: 887 SEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMW 946
Query: 291 LLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG 350
L+TYVGA+FNG+TLL++A + +F++P+VY K++ QID Y+G+ R ++V KIQAK+PG
Sbjct: 947 LMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPG 1006
Query: 351 -AKRHAE 356
AK+ AE
Sbjct: 1007 IAKKKAE 1013
>gi|46255005 reticulon 2 isoform B [Homo sapiens]
Length = 472
Score = 211 bits (536), Expect = 1e-54
Identities = 126/314 (40%), Positives = 185/314 (58%), Gaps = 29/314 (9%)
Query: 50 SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTE 109
S + SS S +P +D P +P+ L ETG EE R L PS+
Sbjct: 156 SGEDSSTSSSTPL--EDEEPQEPNRL-----ETGEAGEELDLRLR--------LAQPSSP 200
Query: 110 PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP--------- 160
P+L PG G + TP P + + +S + P + GP P
Sbjct: 201 EVLTPQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDST 259
Query: 161 --LLFLNKQKAI--DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATI 216
L F + + + DLLYW+D + +G+VF ++ L L FS+VSV A+LAL L TI
Sbjct: 260 DQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTI 319
Query: 217 SFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLV 276
S R+Y+ VLQAV + D +PF+AYL++++TL++EQ ++ + + V S +LR FLV
Sbjct: 320 SLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLV 379
Query: 277 QDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTH 336
+DLVDSLK A+L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV
Sbjct: 380 EDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQ 439
Query: 337 INAVVAKIQAKIPG 350
++ + AKI+AKIPG
Sbjct: 440 LSHIKAKIRAKIPG 453
>gi|41393606 reticulon 3 isoform d [Homo sapiens]
Length = 241
Score = 204 bits (520), Expect = 8e-53
Identities = 105/189 (55%), Positives = 140/189 (74%), Gaps = 5/189 (2%)
Query: 138 SSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAI---DLLYWRDIKQTGIVFGSFLLLLFS 194
SS P+A G G PGA P L + + DL++WRD+K+TG VFG+ L++L S
Sbjct: 16 SSFGAEPSAPGGGG--SPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLS 73
Query: 195 LTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQK 254
L FSV+SVV+YL LA LS TISFRIYKSV+QAVQK++EGHPFKAYL+++ITLS E
Sbjct: 74 LAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHN 133
Query: 255 YTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFT 314
Y + ++N LK + RLFLV+DLVDSLK AV MWL+TYVGA+FNG+TLL++A + +F+
Sbjct: 134 YMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFS 193
Query: 315 LPVVYVKHQ 323
+P+VY K++
Sbjct: 194 VPIVYEKYK 202
>gi|5032055 reticulon 2 isoform A [Homo sapiens]
Length = 545
Score = 197 bits (501), Expect = 1e-50
Identities = 94/183 (51%), Positives = 137/183 (74%)
Query: 168 KAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 227
K DLLYW+D + +G+VF ++ L L FS+VSV A+LAL L TIS R+Y+ VLQA
Sbjct: 344 KVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQA 403
Query: 228 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAV 287
V + D +PF+AYL++++TL++EQ ++ + + V S +LR FLV+DLVDSLK A+
Sbjct: 404 VHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLAL 463
Query: 288 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAK 347
L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV ++ + AKI+AK
Sbjct: 464 LFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAK 523
Query: 348 IPG 350
IPG
Sbjct: 524 IPG 526
Score = 31.2 bits (69), Expect = 1.5
Identities = 30/106 (28%), Positives = 43/106 (40%), Gaps = 16/106 (15%)
Query: 50 SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTE 109
S + SS S +P +D P +P+ L ETG EE R L PS+
Sbjct: 156 SGEDSSTSSSTPL--EDEEPQEPNRL-----ETGEAGEELDLRLR--------LAQPSSP 200
Query: 110 PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGP 155
P+L PG G + TP P + + +S + P + GP
Sbjct: 201 EVLTPQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGP 245
>gi|46255007 reticulon 2 isoform C [Homo sapiens]
Length = 205
Score = 197 bits (501), Expect = 1e-50
Identities = 94/183 (51%), Positives = 137/183 (74%)
Query: 168 KAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 227
K DLLYW+D + +G+VF ++ L L FS+VSV A+LAL L TIS R+Y+ VLQA
Sbjct: 4 KVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQA 63
Query: 228 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAV 287
V + D +PF+AYL++++TL++EQ ++ + + V S +LR FLV+DLVDSLK A+
Sbjct: 64 VHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLAL 123
Query: 288 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAK 347
L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV ++ + AKI+AK
Sbjct: 124 LFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAK 183
Query: 348 IPG 350
IPG
Sbjct: 184 IPG 186
>gi|114155127 regulator of G-protein signalling 3 isoform 6 [Homo
sapiens]
Length = 1198
Score = 43.1 bits (100), Expect = 4e-04
Identities = 29/72 (40%), Positives = 33/72 (45%), Gaps = 21/72 (29%)
Query: 99 PGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGP-------- 150
PG+ PS EP PG ELPPG LP P +DS S Q PA ++ P
Sbjct: 699 PGAEDSPPSKEPSPGQELPPGQD--------LP--PNKDSPSGQEPAPSQEPLSSKDSAT 748
Query: 151 ---GPLGPGAPP 159
P GP APP
Sbjct: 749 SEGSPPGPDAPP 760
Score = 37.0 bits (84), Expect = 0.027
Identities = 53/180 (29%), Positives = 74/180 (41%), Gaps = 23/180 (12%)
Query: 3 AEDALPSGYVSFGHVGGP----PPSPASPSIQYSILREEREAELDSELIIESCDASSASE 58
AED+ PS S G P PP+ SPS Q +E + DS + + S
Sbjct: 701 AEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSA----TSEGSPPGP 756
Query: 59 ESPKREQDSPPMK--PSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPEL 116
++P +D PP + P A D + +E P + +P D P+ + P +L
Sbjct: 757 DAPP-SKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQ----DPLLTKDLPAIQESPTRDL 811
Query: 117 PPGDGALEPETPMLPRK--PEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLY 174
PP L P LP K E+ SS AAT P P AP P F+ + +D Y
Sbjct: 812 PPCQD-LPPSQVSLPAKALTEDTMSSGDLLAATGDP----PAAPRP-AFVIPEVRLDSTY 865
Score = 36.2 bits (82), Expect = 0.046
Identities = 30/117 (25%), Positives = 45/117 (38%), Gaps = 7/117 (5%)
Query: 37 EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGL 96
E EA+ E+ +E A + P +E P D + +E APS+
Sbjct: 682 ETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQ--- 738
Query: 97 AEPGSFLDYPSTE-PQPGPELPPGDGA--LEPETPMLPRKPEEDSSSNQSPAATKGP 150
EP S D ++E PGP+ PP + P P +D + Q P + P
Sbjct: 739 -EPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDP 794
>gi|10864075 regulator of G-protein signalling 3 isoform 2 [Homo
sapiens]
Length = 519
Score = 43.1 bits (100), Expect = 4e-04
Identities = 29/72 (40%), Positives = 33/72 (45%), Gaps = 21/72 (29%)
Query: 99 PGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGP-------- 150
PG+ PS EP PG ELPPG LP P +DS S Q PA ++ P
Sbjct: 20 PGAEDSPPSKEPSPGQELPPGQD--------LP--PNKDSPSGQEPAPSQEPLSSKDSAT 69
Query: 151 ---GPLGPGAPP 159
P GP APP
Sbjct: 70 SEGSPPGPDAPP 81
Score = 37.0 bits (84), Expect = 0.027
Identities = 53/180 (29%), Positives = 74/180 (41%), Gaps = 23/180 (12%)
Query: 3 AEDALPSGYVSFGHVGGP----PPSPASPSIQYSILREEREAELDSELIIESCDASSASE 58
AED+ PS S G P PP+ SPS Q +E + DS + + S
Sbjct: 22 AEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSA----TSEGSPPGP 77
Query: 59 ESPKREQDSPPMK--PSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPEL 116
++P +D PP + P A D + +E P + +P D P+ + P +L
Sbjct: 78 DAPP-SKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQ----DPLLTKDLPAIQESPTRDL 132
Query: 117 PPGDGALEPETPMLPRK--PEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLY 174
PP L P LP K E+ SS AAT P P AP P F+ + +D Y
Sbjct: 133 PPCQD-LPPSQVSLPAKALTEDTMSSGDLLAATGDP----PAAPRP-AFVIPEVRLDSTY 186
Score = 36.2 bits (82), Expect = 0.046
Identities = 30/117 (25%), Positives = 45/117 (38%), Gaps = 7/117 (5%)
Query: 37 EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGL 96
E EA+ E+ +E A + P +E P D + +E APS+
Sbjct: 3 ETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQ--- 59
Query: 97 AEPGSFLDYPSTE-PQPGPELPPGDGA--LEPETPMLPRKPEEDSSSNQSPAATKGP 150
EP S D ++E PGP+ PP + P P +D + Q P + P
Sbjct: 60 -EPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDP 115
>gi|62865651 regulator of G-protein signalling 3 isoform 1 [Homo
sapiens]
Length = 917
Score = 43.1 bits (100), Expect = 4e-04
Identities = 29/72 (40%), Positives = 33/72 (45%), Gaps = 21/72 (29%)
Query: 99 PGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGP-------- 150
PG+ PS EP PG ELPPG LP P +DS S Q PA ++ P
Sbjct: 418 PGAEDSPPSKEPSPGQELPPGQD--------LP--PNKDSPSGQEPAPSQEPLSSKDSAT 467
Query: 151 ---GPLGPGAPP 159
P GP APP
Sbjct: 468 SEGSPPGPDAPP 479
Score = 37.0 bits (84), Expect = 0.027
Identities = 53/180 (29%), Positives = 74/180 (41%), Gaps = 23/180 (12%)
Query: 3 AEDALPSGYVSFGHVGGP----PPSPASPSIQYSILREEREAELDSELIIESCDASSASE 58
AED+ PS S G P PP+ SPS Q +E + DS + + S
Sbjct: 420 AEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSA----TSEGSPPGP 475
Query: 59 ESPKREQDSPPMK--PSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPEL 116
++P +D PP + P A D + +E P + +P D P+ + P +L
Sbjct: 476 DAPP-SKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQ----DPLLTKDLPAIQESPTRDL 530
Query: 117 PPGDGALEPETPMLPRK--PEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLY 174
PP L P LP K E+ SS AAT P P AP P F+ + +D Y
Sbjct: 531 PPCQD-LPPSQVSLPAKALTEDTMSSGDLLAATGDP----PAAPRP-AFVIPEVRLDSTY 584
Score = 36.2 bits (82), Expect = 0.046
Identities = 30/117 (25%), Positives = 45/117 (38%), Gaps = 7/117 (5%)
Query: 37 EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGL 96
E EA+ E+ +E A + P +E P D + +E APS+
Sbjct: 401 ETEADEKREMALEEGKGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQEPAPSQ--- 457
Query: 97 AEPGSFLDYPSTE-PQPGPELPPGDGA--LEPETPMLPRKPEEDSSSNQSPAATKGP 150
EP S D ++E PGP+ PP + P P +D + Q P + P
Sbjct: 458 -EPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEPLPHQDP 513
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/158 (29%), Positives = 64/158 (40%), Gaps = 24/158 (15%)
Query: 20 PPPSPASPSIQYSILREEREAELDSELI----IESCDASSASEESPKREQDSPPMKPSAL 75
PP S +P + + + +A L + L+ D SA E+P+ + P+
Sbjct: 457 PPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRK---PVTAQER 513
Query: 76 DAIREETGVRAEERAPSR-----------RGLAEPGSFLDYPSTEPQPGPELPPGDGAL- 123
REE R +ERA R RG G PST+P G L D +L
Sbjct: 514 QREREEKRRRRQERAKEREKRRQERERKERGAGASGG----PSTDPLAGLVLSDNDRSLL 569
Query: 124 EPETPML-PRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
E T M P P S +PA T P P+ P +PPP
Sbjct: 570 ERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPP 607
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/158 (29%), Positives = 64/158 (40%), Gaps = 24/158 (15%)
Query: 20 PPPSPASPSIQYSILREEREAELDSELI----IESCDASSASEESPKREQDSPPMKPSAL 75
PP S +P + + + +A L + L+ D SA E+P+ + P+
Sbjct: 457 PPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRK---PVTAQER 513
Query: 76 DAIREETGVRAEERAPSR-----------RGLAEPGSFLDYPSTEPQPGPELPPGDGAL- 123
REE R +ERA R RG G PST+P G L D +L
Sbjct: 514 QREREEKRRRRQERAKEREKRRQERERKERGAGASGG----PSTDPLAGLVLSDNDRSLL 569
Query: 124 EPETPML-PRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
E T M P P S +PA T P P+ P +PPP
Sbjct: 570 ERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPP 607
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/158 (29%), Positives = 64/158 (40%), Gaps = 24/158 (15%)
Query: 20 PPPSPASPSIQYSILREEREAELDSELI----IESCDASSASEESPKREQDSPPMKPSAL 75
PP S +P + + + +A L + L+ D SA E+P+ + P+
Sbjct: 457 PPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRK---PVTAQER 513
Query: 76 DAIREETGVRAEERAPSR-----------RGLAEPGSFLDYPSTEPQPGPELPPGDGAL- 123
REE R +ERA R RG G PST+P G L D +L
Sbjct: 514 QREREEKRRRRQERAKEREKRRQERERKERGAGASGG----PSTDPLAGLVLSDNDRSLL 569
Query: 124 EPETPML-PRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
E T M P P S +PA T P P+ P +PPP
Sbjct: 570 ERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPP 607
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/158 (29%), Positives = 64/158 (40%), Gaps = 24/158 (15%)
Query: 20 PPPSPASPSIQYSILREEREAELDSELI----IESCDASSASEESPKREQDSPPMKPSAL 75
PP S +P + + + +A L + L+ D SA E+P+ + P+
Sbjct: 318 PPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRK---PVTAQER 374
Query: 76 DAIREETGVRAEERAPSR-----------RGLAEPGSFLDYPSTEPQPGPELPPGDGAL- 123
REE R +ERA R RG G PST+P G L D +L
Sbjct: 375 QREREEKRRRRQERAKEREKRRQERERKERGAGASGG----PSTDPLAGLVLSDNDRSLL 430
Query: 124 EPETPML-PRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
E T M P P S +PA T P P+ P +PPP
Sbjct: 431 ERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPP 468
>gi|33286446 opioid growth factor receptor [Homo sapiens]
Length = 677
Score = 42.0 bits (97), Expect = 8e-04
Identities = 47/146 (32%), Positives = 60/146 (41%), Gaps = 18/146 (12%)
Query: 20 PPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIR 79
P PSPA P+ + AE SE A A +E + ++P +P+ A
Sbjct: 522 PGPSPAGPA-------GDEPAESPSETPGPR-PAGPAGDEPAESPSETPGPRPAG-PAGD 572
Query: 80 EETGVRAEERAPSRRGLA--EPGSFLDYPSTEPQPGPELPPGDGALE--PETP-MLPRKP 134
E +E PS G EP + PS P P P P GD E ETP P P
Sbjct: 573 EPAESPSETPGPSPAGPTRDEPA---ESPSETPGPRPAGPAGDEPAESPSETPGPRPAGP 629
Query: 135 EEDSSSNQSPAATKGPGPLGPGAPPP 160
D + +SP+ T GP P GP P
Sbjct: 630 AGDEPA-ESPSETPGPSPAGPTRDEP 654
Score = 40.0 bits (92), Expect = 0.003
Identities = 35/85 (41%), Positives = 38/85 (44%), Gaps = 12/85 (14%)
Query: 81 ETGVRAEERAPSRRGLAE--PGSFLDYPSTEPQPGPELPPGDGALE--PETP-MLPRKPE 135
E GV EE R G E PGS PS P P P P GD E ETP P P
Sbjct: 497 ENGV--EEDTEGRTGPKEGTPGS----PSETPGPSPAGPAGDEPAESPSETPGPRPAGPA 550
Query: 136 EDSSSNQSPAATKGPGPLGPGAPPP 160
D + +SP+ T GP P GP P
Sbjct: 551 GDEPA-ESPSETPGPRPAGPAGDEP 574
Score = 37.4 bits (85), Expect = 0.021
Identities = 32/83 (38%), Positives = 37/83 (44%), Gaps = 9/83 (10%)
Query: 83 GVRAEERAPSRRGLA--EPGSFLDYPSTEPQPGPELPPGDGALE--PETP-MLPRKPEED 137
G +E PS G A EP + PS P P P P GD E ETP P P D
Sbjct: 516 GSPSETPGPSPAGPAGDEPA---ESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGD 572
Query: 138 SSSNQSPAATKGPGPLGPGAPPP 160
+ +SP+ T GP P GP P
Sbjct: 573 EPA-ESPSETPGPSPAGPTRDEP 594
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
Length = 1747
Score = 41.6 bits (96), Expect = 0.001
Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 10/156 (6%)
Query: 17 VGGPPPSPA---SPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPS 73
+ GP PSP SP+ E ++ +E D S+S+ P E S S
Sbjct: 1339 LAGPGPSPTTVPSPASGKPSSEPPPAPESAADSGVEEADTRSSSD--PHLETTSTISTVS 1396
Query: 74 ALDAIREETGVRAEERAPSRRGLAEPGSFL-DYPSTEPQPGPELPPGDGALEPETPMLPR 132
++ + E+G E + A+ +FL + P P+P + P G G + P+L +
Sbjct: 1397 SMSTLSSESG----ELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQ 1452
Query: 133 KPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQK 168
+ + + Q AA+ G A P LF + K
Sbjct: 1453 SSDSELMAQQHHAASAGLASAAGPARPRYLFQRRSK 1488
Score = 34.7 bits (78), Expect = 0.13
Identities = 36/147 (24%), Positives = 56/147 (38%), Gaps = 14/147 (9%)
Query: 20 PPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIR 79
PPP +PS ++ + AEL+ I E + P ++P DA
Sbjct: 694 PPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAE--PTLRPDIADA-- 749
Query: 80 EETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSS 139
+ ++R SRR P + PGPE P G+L P E++
Sbjct: 750 DSRAATVKQRPTSRR--ITPAEISSLFERQGLPGPEKLP--GSLRKGIPRTKSVGEDEKL 805
Query: 140 SN----QSPAATKGPGPL--GPGAPPP 160
++ + P +T P+ G G PPP
Sbjct: 806 ASLLEGRFPRSTSMQDPVREGRGIPPP 832
Score = 30.8 bits (68), Expect = 1.9
Identities = 31/115 (26%), Positives = 40/115 (34%), Gaps = 9/115 (7%)
Query: 15 GHVGGPPPSPASPSIQYSILREEREAELDSELI-IESCDASSASEESPKREQDSPPMKPS 73
G GG PS +Y + R + L +E A + P +K S
Sbjct: 1569 GGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGAGGAGRPFGLTPPTILKSS 1628
Query: 74 ALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETP 128
+L E VR R+ S R + PS P P P PG GA P P
Sbjct: 1629 SLSIPHEPKEVRFVVRSVSARSRS--------PSPSPLPSPASGPGPGAPGPRRP 1675
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
sapiens]
Length = 2524
Score = 41.2 bits (95), Expect = 0.001
Identities = 40/147 (27%), Positives = 58/147 (39%), Gaps = 17/147 (11%)
Query: 22 PSPASPSIQYSILREEREAEL-----DSELIIESCDASSAS-EESPKREQDSPPMKPSAL 75
P+ AS + + E+ E E + E ++E +A AS E P+ E P ++
Sbjct: 687 PAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSS 746
Query: 76 DAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 135
D E+ A G P + P PGP PP PE P +P
Sbjct: 747 DT---ESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPP------PEDIPAPTEPT 797
Query: 136 EDSSSNQSPAATKGPGPLGPGAPPPLL 162
S + +P T P P P APPP++
Sbjct: 798 PASEATGAP--TPPPAPPSPSAPPPVV 822
Score = 30.0 bits (66), Expect = 3.3
Identities = 35/155 (22%), Positives = 61/155 (39%), Gaps = 35/155 (22%)
Query: 20 PPPSPASPSIQYSIL-REEREAELDS----------------ELIIES--------CDAS 54
PPP+P SPS ++ +EE+E E + EL +++ + +
Sbjct: 808 PPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECT 867
Query: 55 SASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGP 114
+EE P + +D+ + +A A++ E RA + + P D S+
Sbjct: 868 EEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAP---QDSDSSATCSAD 924
Query: 115 ELPPGDGA-----LEPETPMLPRKPEEDSSSNQSP 144
E+ +G L P +L P D +N SP
Sbjct: 925 EVDEAEGGDKNRLLSPRPSLL--TPTGDPRANASP 957
>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
Length = 1497
Score = 40.8 bits (94), Expect = 0.002
Identities = 32/95 (33%), Positives = 39/95 (41%), Gaps = 5/95 (5%)
Query: 69 PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPG-DGALEPET 127
P P L G++ E AP + +E S L P PG PPG GA P
Sbjct: 783 PQGPQGLPGTPGRPGIKGEPGAPGKIVTSEGSSMLTVPGPPGPPGAMGPPGPPGAPGPAG 842
Query: 128 PM-LPRKPEEDSSSNQSPAATKGP-GPLGPGAPPP 160
P LP ++ + Q P GP GP GP P P
Sbjct: 843 PAGLP--GHQEVLNLQGPPGPPGPRGPPGPSIPGP 875
Score = 37.7 bits (86), Expect = 0.016
Identities = 27/91 (29%), Positives = 35/91 (38%), Gaps = 7/91 (7%)
Query: 69 PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETP 128
P P+ L +E ++ P RG PG PS PGP PPG+G P P
Sbjct: 840 PAGPAGLPGHQEVLNLQGPPGPPGPRG--PPG-----PSIPGPPGPRGPPGEGLPGPPGP 892
Query: 129 MLPRKPEEDSSSNQSPAATKGPGPLGPGAPP 159
++ + P PGP G PP
Sbjct: 893 PGSFLSNSETFLSGPPGPPGPPGPKGDQGPP 923
Score = 31.2 bits (69), Expect = 1.5
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 5/51 (9%)
Query: 112 PGPELPPGDGALEPETPM---LPRKPEEDSSSNQSPAATKGPGPLGPGAPP 159
PGP+ P GD +P P +P P E SS+ + + PGP GP PP
Sbjct: 956 PGPQGPKGDKG-DPGVPGALGIPSGPSEGGSSS-TMYVSGPPGPPGPPGPP 1004
Score = 30.4 bits (67), Expect = 2.5
Identities = 28/99 (28%), Positives = 35/99 (35%), Gaps = 15/99 (15%)
Query: 61 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 120
P + D PM P + E G R P RGL P +PG +
Sbjct: 694 PGVKGDKGPMGPPGPKGDQGEKGPRGLTGEPGMRGL---------PGAVGEPGAK----- 739
Query: 121 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLG-PGAP 158
GA+ P P + P + P PGP G PG P
Sbjct: 740 GAMGPAGPDGHQGPRGEQGLTGMPGIRGPPGPSGDPGKP 778
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/149 (28%), Positives = 51/149 (34%), Gaps = 11/149 (7%)
Query: 20 PPPSPASPSIQYSILREEREAELD--------SELIIESCDASSASEESPKREQDSPPMK 71
PPP P P +L + E LD SE + E +S E E S P+
Sbjct: 594 PPPEPGPPD-PAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPIT 652
Query: 72 PSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLP 131
+ T A APS LA P P P P PP P P LP
Sbjct: 653 SADCPKPMVVTPGAAAVAAPSV--LAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLP 710
Query: 132 RKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P ++ + P P PG PPP
Sbjct: 711 PPPPPPPPAHPAVTVPPPPLPAPPGVPPP 739
Score = 38.1 bits (87), Expect = 0.012
Identities = 48/191 (25%), Positives = 72/191 (37%), Gaps = 54/191 (28%)
Query: 23 SPASPSIQYSIL-REEREAELDSELIIESCDASSASEESPKREQDS-------------- 67
SP+S + ++ REE E E + E++ E AS+ E+ + +++
Sbjct: 1128 SPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGM 1187
Query: 68 ------------PPMKPSALDAIREETGVR--AEERAPSRR-GLAEPGSFL---DYPSTE 109
P +PS LD GV A+ R P GL++ G+ L + P+ E
Sbjct: 1188 EEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKE 1247
Query: 110 PQPGPELPPG-----DGALEPETPML----------PRKPEEDSSSNQSPAATKG----- 149
+ P L P D +EPE PM+ P +P S P T
Sbjct: 1248 VEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSV 1307
Query: 150 -PGPLGPGAPP 159
P PL PP
Sbjct: 1308 PPEPLAEDHPP 1318
Score = 33.1 bits (74), Expect = 0.39
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 3/92 (3%)
Query: 66 DSPPMKPSALDAI-REETGVRAEERAPSRRGLAEPGSF-LDYPSTE-PQPGPELPPGDGA 122
D P ++P A A+ RE + + + P +P + LD+ + P P P LPP
Sbjct: 1490 DGPLVRPPAGAALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPP 1549
Query: 123 LEPETPMLPRKPEEDSSSNQSPAATKGPGPLG 154
P P+ P K NQ P+ PGP G
Sbjct: 1550 PPPPPPVEPTKLPFKELDNQWPSEAIPPGPRG 1581
Score = 30.4 bits (67), Expect = 2.5
Identities = 40/159 (25%), Positives = 60/159 (37%), Gaps = 28/159 (17%)
Query: 18 GGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSAL-- 75
GG S S + EE EAE + E + D S +ES ++D+ + S
Sbjct: 1032 GGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDE 1091
Query: 76 -DAIREETG--VRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPR 132
D+ EET V ++ A S +E F + P + E E ++ R
Sbjct: 1092 GDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSP----------SSSEDEEEVVAR 1141
Query: 133 KPEEDSSSNQSPA----ATKGP---------GPLGPGAP 158
+ EE+ + A A+ GP L PGAP
Sbjct: 1142 EEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAP 1180
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 40.4 bits (93), Expect = 0.002
Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 15/101 (14%)
Query: 60 SPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPG 119
+PK+ + P +P+ +E T +E AP+ + EP P+T +P P P
Sbjct: 305 TPKKPAPTTPKEPAPTTP-KEPTPTTPKEPAPTTK---EPA-----PTTPKEPAPTAP-- 353
Query: 120 DGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
+ P P++P + +P TK P P P P P
Sbjct: 354 ----KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 390
Score = 39.3 bits (90), Expect = 0.005
Identities = 26/109 (23%), Positives = 41/109 (37%), Gaps = 9/109 (8%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPG 113
++ E SP ++ P + +E + AP+ EP P+T +P
Sbjct: 375 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP--KEPS-----PTTTKEPA 427
Query: 114 PELPPGDGALEPE--TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P+ P P++P + +P TK P P P P P
Sbjct: 428 PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 476
Score = 38.9 bits (89), Expect = 0.007
Identities = 29/117 (24%), Positives = 45/117 (38%), Gaps = 10/117 (8%)
Query: 54 SSASEESPKREQDSPPM-KPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQP 112
++ E +P + +P K A +E +E AP+ P + P+T +P
Sbjct: 242 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 301
Query: 113 GPELPPGDGALEPETPM-------LPRKPEEDSSSNQSPAAT--KGPGPLGPGAPPP 160
P P P+ P P P+E + + + PA T K P P P P P
Sbjct: 302 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 358
Score = 37.4 bits (85), Expect = 0.021
Identities = 23/109 (21%), Positives = 41/109 (37%), Gaps = 2/109 (1%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPG 113
++ E +P +++ P P + + P+ + LA + +T +P
Sbjct: 557 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 616
Query: 114 PELPPGDGALEPE--TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P G P+ P P++P + +P K P P P P P
Sbjct: 617 PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 665
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/111 (26%), Positives = 42/111 (37%), Gaps = 6/111 (5%)
Query: 53 ASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSR-RGLAEPGSFLDYPSTEPQ 111
A + +E P K A +E T ++ AP+ +G A P+T +
Sbjct: 579 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 638
Query: 112 PGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P G L+ P P+KP + +P TKGP P P
Sbjct: 639 PAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTTTKGPTSTTSDKPAP 686
Score = 34.7 bits (78), Expect = 0.13
Identities = 29/109 (26%), Positives = 43/109 (39%), Gaps = 14/109 (12%)
Query: 60 SPKREQDSPPMKPS-------ALDAIREETGVRAEERAPSRRGLAEPGSFLD-YPSTEPQ 111
+P++ + P KP+ A E T EE AP+ A P + + P+T +
Sbjct: 494 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 553
Query: 112 PGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P EP P P++ + +P K P P P P P
Sbjct: 554 PAPTTPK-----EP-APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 596
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/97 (25%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 64 EQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGAL 123
++ +P SA +E + +E AP+ EP P+T +P P P
Sbjct: 401 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--KEPA-----PTTPKKPAPTTPK----- 448
Query: 124 EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
EP P P++P ++ +P K P P P P
Sbjct: 449 EP-APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 484
Score = 31.2 bits (69), Expect = 1.5
Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 18/104 (17%)
Query: 57 SEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPEL 116
++ +PK E + K AL +E T +E A + P + P+T +P P
Sbjct: 195 AKPTPKAETTT---KGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP-- 249
Query: 117 PPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P++P +P TK P P P P P
Sbjct: 250 -----TTTKSAPTTPKEP--------APTTTKEPAPTTPKEPAP 280
Score = 30.0 bits (66), Expect = 3.3
Identities = 29/124 (23%), Positives = 46/124 (37%), Gaps = 24/124 (19%)
Query: 54 SSASEESPKREQDSPPM-KPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQP 112
++ E +P ++ +P K A A ++ +E AP+ EP P+T +P
Sbjct: 328 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP--KEPA-----PTTTKEP 380
Query: 113 GPELP----PGDGALEPET------------PMLPRKPEEDSSSNQSPAATKGPGPLGPG 156
P P P P T P P++P ++ +P K P P P
Sbjct: 381 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 440
Query: 157 APPP 160
P P
Sbjct: 441 KPAP 444
Score = 29.3 bits (64), Expect = 5.6
Identities = 26/108 (24%), Positives = 41/108 (37%), Gaps = 13/108 (12%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDY-PSTEPQP 112
++ E +P +++ P P L T E+ AP+ P + + P+T +P
Sbjct: 469 TTPKEPAPTTPKETAPTTPKKL------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 522
Query: 113 GPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P+ P P+E +P K P P P P P
Sbjct: 523 TPTTPEEPAPTTPKAAA-PNTPKE-----PAPTTPKEPAPTTPKEPAP 564
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 40.4 bits (93), Expect = 0.002
Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 15/101 (14%)
Query: 60 SPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPG 119
+PK+ + P +P+ +E T +E AP+ + EP P+T +P P P
Sbjct: 346 TPKKPAPTTPKEPAPTTP-KEPTPTTPKEPAPTTK---EPA-----PTTPKEPAPTAP-- 394
Query: 120 DGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
+ P P++P + +P TK P P P P P
Sbjct: 395 ----KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 431
Score = 39.3 bits (90), Expect = 0.005
Identities = 26/109 (23%), Positives = 41/109 (37%), Gaps = 9/109 (8%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPG 113
++ E SP ++ P + +E + AP+ EP P+T +P
Sbjct: 416 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP--KEPS-----PTTTKEPA 468
Query: 114 PELPPGDGALEPE--TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P+ P P++P + +P TK P P P P P
Sbjct: 469 PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 517
Score = 38.9 bits (89), Expect = 0.007
Identities = 29/117 (24%), Positives = 45/117 (38%), Gaps = 10/117 (8%)
Query: 54 SSASEESPKREQDSPPM-KPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQP 112
++ E +P + +P K A +E +E AP+ P + P+T +P
Sbjct: 283 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 342
Query: 113 GPELPPGDGALEPETPM-------LPRKPEEDSSSNQSPAAT--KGPGPLGPGAPPP 160
P P P+ P P P+E + + + PA T K P P P P P
Sbjct: 343 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 399
Score = 37.4 bits (85), Expect = 0.021
Identities = 23/109 (21%), Positives = 41/109 (37%), Gaps = 2/109 (1%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPG 113
++ E +P +++ P P + + P+ + LA + +T +P
Sbjct: 598 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 657
Query: 114 PELPPGDGALEPE--TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P G P+ P P++P + +P K P P P P P
Sbjct: 658 PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 706
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/111 (26%), Positives = 42/111 (37%), Gaps = 6/111 (5%)
Query: 53 ASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSR-RGLAEPGSFLDYPSTEPQ 111
A + +E P K A +E T ++ AP+ +G A P+T +
Sbjct: 620 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 679
Query: 112 PGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P G L+ P P+KP + +P TKGP P P
Sbjct: 680 PAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTTTKGPTSTTSDKPAP 727
Score = 34.7 bits (78), Expect = 0.13
Identities = 29/109 (26%), Positives = 43/109 (39%), Gaps = 14/109 (12%)
Query: 60 SPKREQDSPPMKPS-------ALDAIREETGVRAEERAPSRRGLAEPGSFLD-YPSTEPQ 111
+P++ + P KP+ A E T EE AP+ A P + + P+T +
Sbjct: 535 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 594
Query: 112 PGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P EP P P++ + +P K P P P P P
Sbjct: 595 PAPTTPK-----EP-APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 637
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/97 (25%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 64 EQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGAL 123
++ +P SA +E + +E AP+ EP P+T +P P P
Sbjct: 442 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--KEPA-----PTTPKKPAPTTPK----- 489
Query: 124 EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
EP P P++P ++ +P K P P P P
Sbjct: 490 EP-APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 525
Score = 31.2 bits (69), Expect = 1.5
Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 18/104 (17%)
Query: 57 SEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPEL 116
++ +PK E + K AL +E T +E A + P + P+T +P P
Sbjct: 236 AKPTPKAETTT---KGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP-- 290
Query: 117 PPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P++P +P TK P P P P P
Sbjct: 291 -----TTTKSAPTTPKEP--------APTTTKEPAPTTPKEPAP 321
Score = 30.0 bits (66), Expect = 3.3
Identities = 29/124 (23%), Positives = 46/124 (37%), Gaps = 24/124 (19%)
Query: 54 SSASEESPKREQDSPPM-KPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQP 112
++ E +P ++ +P K A A ++ +E AP+ EP P+T +P
Sbjct: 369 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP--KEPA-----PTTTKEP 421
Query: 113 GPELP----PGDGALEPET------------PMLPRKPEEDSSSNQSPAATKGPGPLGPG 156
P P P P T P P++P ++ +P K P P P
Sbjct: 422 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 481
Query: 157 APPP 160
P P
Sbjct: 482 KPAP 485
Score = 29.3 bits (64), Expect = 5.6
Identities = 26/108 (24%), Positives = 41/108 (37%), Gaps = 13/108 (12%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDY-PSTEPQP 112
++ E +P +++ P P L T E+ AP+ P + + P+T +P
Sbjct: 510 TTPKEPAPTTPKETAPTTPKKL------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 563
Query: 113 GPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P+ P P+E +P K P P P P P
Sbjct: 564 TPTTPEEPAPTTPKAAA-PNTPKE-----PAPTTPKEPAPTTPKEPAP 605
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 40.4 bits (93), Expect = 0.002
Identities = 27/101 (26%), Positives = 43/101 (42%), Gaps = 15/101 (14%)
Query: 60 SPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPG 119
+PK+ + P +P+ +E T +E AP+ + EP P+T +P P P
Sbjct: 398 TPKKPAPTTPKEPAPTTP-KEPTPTTPKEPAPTTK---EPA-----PTTPKEPAPTAP-- 446
Query: 120 DGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
+ P P++P + +P TK P P P P P
Sbjct: 447 ----KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 483
Score = 39.3 bits (90), Expect = 0.005
Identities = 26/109 (23%), Positives = 41/109 (37%), Gaps = 9/109 (8%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPG 113
++ E SP ++ P + +E + AP+ EP P+T +P
Sbjct: 468 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP--KEPS-----PTTTKEPA 520
Query: 114 PELPPGDGALEPE--TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P+ P P++P + +P TK P P P P P
Sbjct: 521 PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 569
Score = 38.9 bits (89), Expect = 0.007
Identities = 29/117 (24%), Positives = 45/117 (38%), Gaps = 10/117 (8%)
Query: 54 SSASEESPKREQDSPPM-KPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQP 112
++ E +P + +P K A +E +E AP+ P + P+T +P
Sbjct: 335 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 394
Query: 113 GPELPPGDGALEPETPM-------LPRKPEEDSSSNQSPAAT--KGPGPLGPGAPPP 160
P P P+ P P P+E + + + PA T K P P P P P
Sbjct: 395 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP 451
Score = 37.4 bits (85), Expect = 0.021
Identities = 23/109 (21%), Positives = 41/109 (37%), Gaps = 2/109 (1%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPG 113
++ E +P +++ P P + + P+ + LA + +T +P
Sbjct: 650 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 709
Query: 114 PELPPGDGALEPE--TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P G P+ P P++P + +P K P P P P P
Sbjct: 710 PTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 758
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/111 (26%), Positives = 42/111 (37%), Gaps = 6/111 (5%)
Query: 53 ASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSR-RGLAEPGSFLDYPSTEPQ 111
A + +E P K A +E T ++ AP+ +G A P+T +
Sbjct: 672 APTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKE 731
Query: 112 PGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P G L+ P P+KP + +P TKGP P P
Sbjct: 732 PAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTTTKGPTSTTSDKPAP 779
Score = 34.7 bits (78), Expect = 0.13
Identities = 29/109 (26%), Positives = 43/109 (39%), Gaps = 14/109 (12%)
Query: 60 SPKREQDSPPMKPS-------ALDAIREETGVRAEERAPSRRGLAEPGSFLD-YPSTEPQ 111
+P++ + P KP+ A E T EE AP+ A P + + P+T +
Sbjct: 587 TPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 646
Query: 112 PGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P EP P P++ + +P K P P P P P
Sbjct: 647 PAPTTPK-----EP-APTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAP 689
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/97 (25%), Positives = 39/97 (40%), Gaps = 13/97 (13%)
Query: 64 EQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGAL 123
++ +P SA +E + +E AP+ EP P+T +P P P
Sbjct: 494 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP--KEPA-----PTTPKKPAPTTPK----- 541
Query: 124 EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
EP P P++P ++ +P K P P P P
Sbjct: 542 EP-APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 577
Score = 31.2 bits (69), Expect = 1.5
Identities = 26/104 (25%), Positives = 39/104 (37%), Gaps = 18/104 (17%)
Query: 57 SEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPEL 116
++ +PK E + K AL +E T +E A + P + P+T +P P
Sbjct: 288 AKPTPKAETTT---KGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP-- 342
Query: 117 PPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P++P +P TK P P P P P
Sbjct: 343 -----TTTKSAPTTPKEP--------APTTTKEPAPTTPKEPAP 373
Score = 30.0 bits (66), Expect = 3.3
Identities = 29/124 (23%), Positives = 46/124 (37%), Gaps = 24/124 (19%)
Query: 54 SSASEESPKREQDSPPM-KPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQP 112
++ E +P ++ +P K A A ++ +E AP+ EP P+T +P
Sbjct: 421 TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP--KEPA-----PTTTKEP 473
Query: 113 GPELP----PGDGALEPET------------PMLPRKPEEDSSSNQSPAATKGPGPLGPG 156
P P P P T P P++P ++ +P K P P P
Sbjct: 474 SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 533
Query: 157 APPP 160
P P
Sbjct: 534 KPAP 537
Score = 29.3 bits (64), Expect = 5.6
Identities = 26/108 (24%), Positives = 41/108 (37%), Gaps = 13/108 (12%)
Query: 54 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDY-PSTEPQP 112
++ E +P +++ P P L T E+ AP+ P + + P+T +P
Sbjct: 562 TTPKEPAPTTPKETAPTTPKKL------TPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 615
Query: 113 GPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 160
P P P+ P P+E +P K P P P P P
Sbjct: 616 TPTTPEEPAPTTPKAAA-PNTPKE-----PAPTTPKEPAPTTPKEPAP 657
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,917,726
Number of Sequences: 37866
Number of extensions: 927803
Number of successful extensions: 9994
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 786
Number of HSP's that attempted gapping in prelim test: 7251
Number of HSP's gapped (non-prelim): 3056
length of query: 356
length of database: 18,247,518
effective HSP length: 103
effective length of query: 253
effective length of database: 14,347,320
effective search space: 3629871960
effective search space used: 3629871960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.