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Search of human proteins with 131888105
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|131888105 cancer susceptibility candidate 1 isoform a [Homo
sapiens]
(722 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|131888105 cancer susceptibility candidate 1 isoform a [Homo s... 1436 0.0
gi|131889097 cancer susceptibility candidate 1 isoform b [Homo s... 1422 0.0
gi|131889447 cancer susceptibility candidate 1 isoform c [Homo s... 1253 0.0
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 57 8e-08
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 55 3e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 54 4e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 54 7e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 51 3e-06
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 51 4e-06
gi|154354979 myosin X [Homo sapiens] 49 2e-05
gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo sap... 49 2e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 48 3e-05
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 48 3e-05
gi|116174778 centrosome spindle pole associated protein 1 isofor... 48 3e-05
gi|116174789 centrosome spindle pole associated protein 1 isofor... 48 3e-05
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 48 4e-05
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 48 4e-05
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 47 5e-05
gi|38044112 restin isoform b [Homo sapiens] 47 6e-05
gi|4506751 restin isoform a [Homo sapiens] 47 6e-05
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 47 6e-05
gi|221219020 NYD-SP11 protein [Homo sapiens] 46 1e-04
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 46 1e-04
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 46 1e-04
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 46 1e-04
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 46 1e-04
gi|92859701 myosin VI [Homo sapiens] 46 1e-04
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 46 1e-04
>gi|131888105 cancer susceptibility candidate 1 isoform a [Homo
sapiens]
Length = 722
Score = 1436 bits (3717), Expect = 0.0
Identities = 722/722 (100%), Positives = 722/722 (100%)
Query: 1 MGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKW 60
MGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKW
Sbjct: 1 MGPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKW 60
Query: 61 HRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMN 120
HRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMN
Sbjct: 61 HRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMN 120
Query: 121 TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 180
TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQE
Sbjct: 121 TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 180
Query: 181 LLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQ 240
LLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQ
Sbjct: 181 LLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQ 240
Query: 241 IGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISK 300
IGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISK
Sbjct: 241 IGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISK 300
Query: 301 EVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAA 360
EVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAA
Sbjct: 301 EVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAA 360
Query: 361 QLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQ 420
QLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQ
Sbjct: 361 QLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQ 420
Query: 421 KYTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYK 480
KYTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYK
Sbjct: 421 KYTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYK 480
Query: 481 PKERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENL 540
PKERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENL
Sbjct: 481 PKERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENL 540
Query: 541 CMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVK 600
CMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVK
Sbjct: 541 CMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVK 600
Query: 601 AYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLK 660
AYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLK
Sbjct: 601 AYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLK 660
Query: 661 IKEESEAFSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLS 720
IKEESEAFSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLS
Sbjct: 661 IKEESEAFSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLS 720
Query: 721 YS 722
YS
Sbjct: 721 YS 722
>gi|131889097 cancer susceptibility candidate 1 isoform b [Homo
sapiens]
Length = 716
Score = 1422 bits (3680), Expect = 0.0
Identities = 715/715 (100%), Positives = 715/715 (100%)
Query: 8 SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD 67
SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD
Sbjct: 2 SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD 61
Query: 68 LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 127
LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK
Sbjct: 62 LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 121
Query: 128 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFG 187
EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFG
Sbjct: 122 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFG 181
Query: 188 VATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPR 247
VATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPR
Sbjct: 182 VATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPR 241
Query: 248 ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESK 307
ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESK
Sbjct: 242 ILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESK 301
Query: 308 QQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVEN 367
QQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVEN
Sbjct: 302 QQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVEN 361
Query: 368 SSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPE 427
SSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPE
Sbjct: 362 SSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPE 421
Query: 428 TTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVT 487
TTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVT
Sbjct: 422 TTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVT 481
Query: 488 FSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIK 547
FSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIK
Sbjct: 482 FSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIK 541
Query: 548 LKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMAL 607
LKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMAL
Sbjct: 542 LKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMAL 601
Query: 608 LSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLKIKEESEA 667
LSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLKIKEESEA
Sbjct: 602 LSSAFAFGWSKWNLLCNSTKVVFKVREHLTEECTENPNWALLMFSGDRAQRLKIKEESEA 661
Query: 668 FSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS 722
FSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS
Sbjct: 662 FSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS 716
>gi|131889447 cancer susceptibility candidate 1 isoform c [Homo
sapiens]
Length = 690
Score = 1253 bits (3242), Expect = 0.0
Identities = 630/630 (100%), Positives = 630/630 (100%)
Query: 2 GPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 61
GPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH
Sbjct: 60 GPKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 119
Query: 62 RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 121
RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT
Sbjct: 120 RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 179
Query: 122 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 181
FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL
Sbjct: 180 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 239
Query: 182 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 241
LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI
Sbjct: 240 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 299
Query: 242 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 301
GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE
Sbjct: 300 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 359
Query: 302 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ 361
VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ
Sbjct: 360 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ 419
Query: 362 LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQK 421
LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQK
Sbjct: 420 LLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQK 479
Query: 422 YTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP 481
YTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP
Sbjct: 480 YTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKP 539
Query: 482 KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLC 541
KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLC
Sbjct: 540 KERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLC 599
Query: 542 MLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA 601
MLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
Sbjct: 600 MLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA 659
Query: 602 YRQMALLSSAFAFGWSKWNLLCNSTKVVFK 631
YRQMALLSSAFAFGWSKWNLLCNSTKVVFK
Sbjct: 660 YRQMALLSSAFAFGWSKWNLLCNSTKVVFK 689
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 56.6 bits (135), Expect = 8e-08
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 6/105 (5%)
Query: 2 GPKAKKSGSKKKKVTKA------ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI 55
G K +K KKK +KA E L L+EEEER+ +EEEE + E+ E +R E +R+
Sbjct: 323 GEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERL 382
Query: 56 EKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 100
E+EK R + K+ ER+ +E LL + EA + T L Q
Sbjct: 383 EQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Score = 41.6 bits (96), Expect = 0.003
Identities = 78/367 (21%), Positives = 149/367 (40%), Gaps = 47/367 (12%)
Query: 14 KVTKAERLKLLQEEEERRLKEEEEARLKY--EKEEMER-LEIQRIEKEKWHRLEAKDLER 70
K+ + K ++E ER+ ++EE+A+L+ EKEE+E + Q +KE + E + ++
Sbjct: 224 KIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKS 283
Query: 71 R----------NEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVA--QE 118
+ +EE E E +K K++ K K + + PS A +
Sbjct: 284 KVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKA 343
Query: 119 MNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL 178
M ++ KE+ E E+ K + L K K E + +++ + +E +L
Sbjct: 344 MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEE--ERLEQEKRERKKQKEKERKERL 401
Query: 179 QELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSE 238
++ L E + +TL L + +E KD KK P + + +
Sbjct: 402 KKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP--------KKRPIYEDKKRKK 453
Query: 239 TQIGFEIPRILATSDI--AVRLLHTHYDHVSALHPVSTPSKEY--------------TSA 282
E + + ++ AV ++ P P +E +
Sbjct: 454 IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDE 513
Query: 283 VTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESE 342
TE V+ + ++E + E EEE +++E +E+E EEE+ + E + S +EE E
Sbjct: 514 ETEKVEGNKVHIEVKENPEEEEEEEEEE------EEDEESEEEEEEEGESEGSEGDEEDE 567
Query: 343 AIKCERE 349
+ E++
Sbjct: 568 KVSDEKD 574
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/101 (33%), Positives = 55/101 (54%), Gaps = 10/101 (9%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEER---RLKEEEEARLKYEKEEMERLE---IQRIEKEK 59
KK KKKK K E+ K ++ + + +E A+LK E+E +R E I+R+E+ +
Sbjct: 314 KKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELE 373
Query: 60 WHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 100
R E + LE+ E ++ ER E+LK+E KLL++
Sbjct: 374 AKRKEEERLEQEKRERKKQKEKER----KERLKKEGKLLTK 410
Score = 35.8 bits (81), Expect = 0.14
Identities = 78/355 (21%), Positives = 142/355 (40%), Gaps = 28/355 (7%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 63
+++K K +K ++ E+++ K + A+ K EK+E ER + EK K +L
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDE-EKAKLRKL 253
Query: 64 EAKD-LERRNEELEELYLLERCFPEA---EKLKQETKLLSQWKHYIQCDGSPDPSVAQEM 119
+ K+ LE ++ + +R F E K+ +T ++ + + + P+ A++
Sbjct: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE-----EKAETPTAAEDD 308
Query: 120 NTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQ 179
N K+K + E+ EK K K ++ L+++ Q +E +++
Sbjct: 309 NEGDKKKKDKKKKKGEKE-EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK 367
Query: 180 ELLHLKFGVATEILLKQASTLADLDSGNMEKV-IKDENVTLYVWANLKKNPRHRSVRFSE 238
L L+ E L+Q K +K E L + +++ +
Sbjct: 368 RLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Query: 239 TQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTS-----AVTELVKDDVKN 293
Q G E+P + D + + D P SKE + A E+++ V
Sbjct: 428 AQ-GVEVP----SKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPE 482
Query: 294 VEKAISK-EVEEESKQQERG-----SHLIQEEEIKVEEEQGDIEVKMSSAEEESE 342
E+ E EEE ++ G + EE KVE + IEVK + EEE E
Sbjct: 483 KEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE 537
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 54.7 bits (130), Expect = 3e-07
Identities = 84/371 (22%), Positives = 160/371 (43%), Gaps = 45/371 (12%)
Query: 15 VTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRN-- 72
+T+ R LQ E E+ AR++ + + LE+Q +E ++ + K+LE
Sbjct: 1050 LTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQ 1109
Query: 73 ------------EELEELYL-LERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEM 119
ELEEL + L++ + +K QE +L+ + D M
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKK-----------DAQQTTLM 1158
Query: 120 NTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQ 179
N I+ ++ E +++ K+ + +L +++K ++ + + I Q S+ Q +
Sbjct: 1159 NMEIADYERLMKELNQKLTNKNNKIEDLEQEIK---IQKQKQETLQEEITSLQSSVQQYE 1215
Query: 180 ELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSET 239
E K ++L+K LAD + +I ++ + A+ ++ ++ T
Sbjct: 1216 E----KNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT 1271
Query: 240 QIGFEIPRILATS-DIAVRLLHTHYDHVSALHPVSTPSKEYTSAVT---ELVKDDVKNV- 294
+I L TS + R L + V+AL +K + VT E K V NV
Sbjct: 1272 SEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL 1331
Query: 295 ----EKAISKEVEEESKQQ-ERGSHLIQEEEIKVEEEQGDIEVKMSSAE--EESEAIKCE 347
K++S+ E +KQ+ E LI + +IK+++ Q ++++ +S + + E
Sbjct: 1332 KQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLE 1391
Query: 348 REMKVLSETVS 358
R K+L ETVS
Sbjct: 1392 RHNKMLQETVS 1402
Score = 38.1 bits (87), Expect = 0.029
Identities = 98/447 (21%), Positives = 203/447 (45%), Gaps = 87/447 (19%)
Query: 8 SGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYE--KEEMERLEIQRIEK-------- 57
S S+K+K+T ++ L+E+ E +E++EA L YE +E ME L+ + E
Sbjct: 446 SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEF 505
Query: 58 EKWHRLEAKDLERRNEELEELY-----LLE---RCFPEAEKLKQETKLLSQWKHYI---- 105
E + +A D+ ++L + LLE R E EKL + +L+ + ++ I
Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQ 565
Query: 106 ------------------QCDGSPDPSVAQEMNTFISLWKEKTNE--TFEEVIEK-SKVV 144
+ +G + S+ +E + FI+ K E F + E+ +++
Sbjct: 566 EKNGVYLLSLSQRDTMLKELEGKIN-SLTEEKDDFINKLKNSHEEMDNFHKKCEREERLI 624
Query: 145 LNLIEKLKFIL-----LETPPCDL----------QDKNIIQYQESILQLQELLHLKFGVA 189
L L +K++ + LE +L +D+N + ++ ++Q++ L K
Sbjct: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDK---- 680
Query: 190 TEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRIL 249
E+L + +L + ++ + K + L V+ + K++ ++ TQ+ ++ ++
Sbjct: 681 -EVLSAEVKSLYE-ENNKLSSEKKQLSRDLEVFLSQKEDV---ILKEHITQLEKKLQLMV 735
Query: 250 ATSDIAVRLLHTHYDHVSALHPVSTP----SKEYTSAVTELVKD-DVKNVEKAISKEVEE 304
D +LL + V L V T KE S V+E ++ DV NV +A+ + + +
Sbjct: 736 EEQDNLNKLLEN--EQVQKLF-VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792
Query: 305 ESKQQ-----ERGSHLIQ-EEEIKVEEEQGDI---EVKMSSAEEESEAIKCEREMKVLSE 355
++++ +R +++ E+EIK +E+ + E+K + E E + +E++ +
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852
Query: 356 TVSAAQ--LLLVENSSEKPDFFEDNVV 380
A Q LL ++N++EK N++
Sbjct: 853 EKEALQSDLLEMKNANEKTRLENQNLL 879
Score = 33.9 bits (76), Expect = 0.54
Identities = 73/409 (17%), Positives = 164/409 (40%), Gaps = 35/409 (8%)
Query: 7 KSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAK 66
K K K + L ++E EE+ E+E + K EK + ++++ ++ +K K
Sbjct: 929 KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEK--INKIKLVAVKAKKELDSSRK 986
Query: 67 DLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVA--QEMNTFIS 124
+ + EELE L ++ +L + + IQ S + ++ + +
Sbjct: 987 ETQTVKEELESL------------RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
Query: 125 LWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHL 184
+ KE+ N FE IE +L +L+ L+ + +++++ E++ +LL +
Sbjct: 1035 VEKERAN-NFEHRIE------DLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEV 1087
Query: 185 KFGVATEILLKQASTLADLDSGNMEK--VIKDENVTLYVWANLKKNPRHRSVRFSETQIG 242
+ E+ +A +L++ ++K IK+ T+ L+ + + +T
Sbjct: 1088 QI---LEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQE 1144
Query: 243 FEIPRILATSDIAVRLLHTHYDH-VSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 301
E+ + A + + Y+ + L+ T + + +K K ++ + +E
Sbjct: 1145 LELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQ-KQKQETLQEE 1203
Query: 302 V---EEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVS 358
+ + +Q E + I++ +K ++E D K + + + E++ + V
Sbjct: 1204 ITSLQSSVQQYEEKNTKIKQLLVKTKKELAD--SKQAETDHLILQASLKGELEASQQQVE 1261
Query: 359 AAQLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVK 407
++ L E +SEK E Q Y + L +C+ K
Sbjct: 1262 VYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310
Score = 33.1 bits (74), Expect = 0.93
Identities = 67/373 (17%), Positives = 163/373 (43%), Gaps = 44/373 (11%)
Query: 35 EEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEE---------LYLLERCF 85
E++A L+ + EE +++ E+ K+ ++++ EE+E+ LYL ++
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206
Query: 86 PEAEKLKQETKLLSQWKHYIQCDGSPDP----SVAQEMNTFISLWKEKTNETFEEVIEKS 141
++ K+ET ++Q ++ I+ + S+ +E+ ++ +E+ E ++ +
Sbjct: 207 ATTDE-KKET--VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
Query: 142 K---VVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQAS 198
K +N + +LK L++ C+ +KNI + E EL +L+ + Q
Sbjct: 264 KEHEAEINKLNELKENLVKQ--CEASEKNIQKKYEC-----ELENLRKATSNANQDNQIC 316
Query: 199 TLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI--GFEIPRILATSDIAV 256
++ ++ +E+V+ ++ ++ LK+ S+ E ++ + I
Sbjct: 317 SILLQENTFVEQVVNEK--VKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKD 374
Query: 257 RLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLI 316
H D ++ + +KE V E +K ++ + K VE+ +++ +
Sbjct: 375 EFFHEREDLEFKINELLL-AKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQH 433
Query: 317 QEEEIKV--------EEEQGDIEVKMSSAEEESEAIKCEREMKVLS-----ETVSAAQLL 363
Q+E ++ E+E+ + ++ +E+ E ++ E++ +L+ E + Q
Sbjct: 434 QKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTE 493
Query: 364 LVENSSEKPDFFE 376
L E++ + FE
Sbjct: 494 LGESAGKISQEFE 506
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 54.3 bits (129), Expect = 4e-07
Identities = 75/345 (21%), Positives = 149/345 (43%), Gaps = 40/345 (11%)
Query: 12 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-MERLEIQRIEKEKWHRLEAKDLER 70
+++ K R + + E+E +++ +EE + +EKEE M R E EKE+ R + + +
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEE--MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 388
Query: 71 RNEELEEL----YLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLW 126
+ E++ EL + E+ + EK ++E K+ Q K QE +
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-------------QEQEAKMWRQ 435
Query: 127 KEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKF 186
+EK E E++ E+ K + EK+ E ++K Q QE + + +E +H
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIH----EQEKIREEEKR--QEQEEMWRQEEKIH--- 486
Query: 187 GVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKK-NPRHRSVRFSETQIGFEI 245
E + +Q + + + EK+ K E VW +K + +R E ++ +
Sbjct: 487 --EQEEIWRQKEKMHEQE----EKIRKQEE---KVWRQEEKIREQEEKIREQEEKMWRQE 537
Query: 246 PRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEE 305
+I ++ H ++ E +++ + V + K E+E
Sbjct: 538 EKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQE 597
Query: 306 SKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREM 350
K+QE+ + ++EE K+ E++ I+ + E+ E I+ + EM
Sbjct: 598 EKRQEQEEKMWKQEE-KIREQEEKIQEQEEKIREQEEKIREQEEM 641
Score = 48.5 bits (114), Expect = 2e-05
Identities = 78/370 (21%), Positives = 156/370 (42%), Gaps = 53/370 (14%)
Query: 11 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI-EKEKWHRLEAK--- 66
K++K+ + E + +EE+ R L+E+ + K ++E +R E ++I E+EK EAK
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 67 -------DLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEM 119
E+ E+ ++++ E E EK+++E K Q + + Q +++
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ---------EEKI 485
Query: 120 NTFISLW--KEKTNETFEEVIEKSKVVLNLIEKLK---FILLETPPCDLQDKNIIQYQES 174
+ +W KEK +E E++ ++ + V EK++ + E + + I+ QE
Sbjct: 486 HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545
Query: 175 ILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSV 234
+ + +E +H + + E ++ D EK+ + E VW +K
Sbjct: 546 MWREEEKMHEQEKIWEE---EKRQEQEDKMWRQEEKIREQEE---KVWRQEEKIREQEEK 599
Query: 235 RFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNV 294
R + + ++ + + + + +E E+ ++ + +
Sbjct: 600 RQEQEEKMWKQEEKIREQE----------EKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649
Query: 295 EKAISKEVEEESKQQE------RGSHLIQEEEIKVEEEQGDI---EVKMSSAEE---ESE 342
+ K E+E K QE R I+E+E K+ E++ I E M EE E E
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 709
Query: 343 AIKCEREMKV 352
CE+E K+
Sbjct: 710 EKMCEQEEKM 719
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/184 (25%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 6 KKSGSKKKKVTKAERLKLLQEE----EERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 61
+K +++K+ K E QEE +E +++E+EE + E++ E+ E+ R E+EK H
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR-EEEKMH 554
Query: 62 RLE-AKDLERRNEELEELYLLERCFPEAEK--LKQETKLLSQWKHYIQCDGS--PDPSVA 116
E + E+R E+ ++++ E E E+ +QE K+ Q + + +
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 117 QEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESIL 176
+E I +EK E E++ E+ ++ EK+ E C+ ++K +Q QE +
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG--EQEEKMCEQEEK--MQEQEETM 670
Query: 177 QLQE 180
QE
Sbjct: 671 WRQE 674
Score = 35.8 bits (81), Expect = 0.14
Identities = 72/364 (19%), Positives = 160/364 (43%), Gaps = 69/364 (18%)
Query: 1 MGPKAKKSGSKKKKVTKAERLKLLQEE---EERRLKEEEEARLKYEKEEM--------ER 49
M + +K +++K+ + E+ QEE E+ +++EEE+ + E+EEM E+
Sbjct: 432 MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK---RQEQEEMWRQEEKIHEQ 488
Query: 50 LEIQRIEKEKWHRLEAK------DLERRNEELEELYLLERCFPEAEKL-KQETKLLSQWK 102
EI R +KEK H E K + R+ E++ E E+ + EK+ +QE K+ Q +
Sbjct: 489 EEIWR-QKEKMHEQEEKIRKQEEKVWRQEEKIREQE--EKIREQEEKMWRQEEKIREQEE 545
Query: 103 HYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCD 162
+ + ++M+ +W+E+ + E+ + + + EK++
Sbjct: 546 MWRE---------EEKMHEQEKIWEEEKRQEQEDKMWRQE------EKIR---------- 580
Query: 163 LQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVW 222
Q++ + + +E I + +E K E + KQ + + + EK+ + E
Sbjct: 581 EQEEKVWRQEEKIREQEE----KRQEQEEKMWKQEEKIREQE----EKIQEQEEKIREQE 632
Query: 223 ANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSA 282
+++ + + E ++G + ++ + T + + +E
Sbjct: 633 EKIRE--QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Query: 283 V---TELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQ-GDIEVKMSSAE 338
+ E++++ + + + K E+E K QE QEE+++ +EE+ + EV++ E
Sbjct: 691 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQE------QEEKMRRQEEKMWEQEVRLRQQE 744
Query: 339 EESE 342
E+ +
Sbjct: 745 EKMQ 748
Score = 33.1 bits (74), Expect = 0.93
Identities = 18/72 (25%), Positives = 45/72 (62%), Gaps = 4/72 (5%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 65
KK +++K+ + E +++QE+EE+ ++EE+ + EK + + +++R E++ W +
Sbjct: 682 KKIREQEEKIREQE--EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE--QE 737
Query: 66 KDLERRNEELEE 77
L ++ E+++E
Sbjct: 738 VRLRQQEEKMQE 749
Score = 32.7 bits (73), Expect = 1.2
Identities = 21/104 (20%), Positives = 59/104 (56%), Gaps = 7/104 (6%)
Query: 1 MGPKAKKSGSKKKKVTKAERLKLLQEE----EERRLKEEEEARLKYEKEEMERLEIQRIE 56
MG + +K +++K+ + E QEE +E++++E+EE +++ ++E M+ E + E
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE-KIREQEEMMQEQEEKMWE 707
Query: 57 KEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 100
+E+ + + ++ + E++ E+ + + +L+Q+ + + +
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQE--EKMWEQEVRLRQQEEKMQE 749
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 53.5 bits (127), Expect = 7e-07
Identities = 80/367 (21%), Positives = 161/367 (43%), Gaps = 36/367 (9%)
Query: 1 MGPKAKKSGSKKKKVTKAERLKLLQEEE---ERRLKEEEEARLKYEKEEMERLEIQRIEK 57
M + +K ++K++ + E+ QE+E ++ L+E+EE + E++ E+ E R ++
Sbjct: 309 MREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE 368
Query: 58 EKWHRLEAKDLERRNEELEELYLL----ERCFPEAEKLKQ-ETKLLSQWKHYIQCDGSPD 112
EK R E + E+ + E+ + ER + + E+L++ E ++ Q K + Q + +
Sbjct: 369 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE 428
Query: 113 PSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQ 172
QE +EK E E + E+ K + E+ + + + Q++N+ + +
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEE-ERIREREK---KMREEEETMREQEEKMQKQEENMWEQE 484
Query: 173 ESILQLQELLHLKFGVATEILLKQASTLADLDS-GNMEKVIKDENVTLYVWANLKKNPRH 231
E Q Q L K E L +Q + E+ I+D+ +W KK R
Sbjct: 485 EKEWQQQRLPEQK-----EKLWEQEKMQEQEEKIWEQEEKIRDQE---EMWGQEKKMWRQ 536
Query: 232 RSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDV 291
+R E Q+ + ++ +D + + ++ T E ++++
Sbjct: 537 EKMREQEDQMWEQEEKMRDQE-------QKMWDQEERMEKKTQEQEKKTWDQEEKMREEE 589
Query: 292 KNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDI---EVKMSSAEE---ESEAIK 345
+ E+ K++ EE + +QE+E K++E++ + E KM EE E E
Sbjct: 590 RMRER--EKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM 647
Query: 346 CEREMKV 352
E+E K+
Sbjct: 648 WEQEEKM 654
Score = 39.7 bits (91), Expect = 0.010
Identities = 43/187 (22%), Positives = 87/187 (46%), Gaps = 27/187 (14%)
Query: 6 KKSGSKKKKVTKAERL-----KLLQEEE-----ERRLKEEEEARLKYEKEEMERLEIQRI 55
KK+ +++K+ + ER+ K+ +EEE E +++E+EE + E++ E+ E +
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Query: 56 EKEKWHRLEAKDLERRNEELEELYLLER--CFPEAEKLKQETKLLSQWKHYIQCDGSPDP 113
++EK E K E+ + E+ L E+ E EK++++ K+ Q + + +
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 114 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 173
+ QE T W ++ E + E+ K + E ++ + + +Q QE
Sbjct: 696 TQEQEKKT----WDQEKMREEESMREREKKMREEEEMMR-----------EQEEKMQEQE 740
Query: 174 SILQLQE 180
+Q QE
Sbjct: 741 EKMQEQE 747
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 8/104 (7%)
Query: 6 KKSGSKKKKVTKAERLK---LLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 62
KK+ ++KK E+++ ++E E++ +EEE R + EK + + ++Q E+E W
Sbjct: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW-- 751
Query: 63 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQ 106
+ E+ E+ E+++ +R + EKL + K+ Q K + Q
Sbjct: 752 ---EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/147 (19%), Positives = 73/147 (49%), Gaps = 19/147 (12%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 65
+K +++K+ + E+++ +E+E++ ++E+ R E+E M E + E+E+ R +
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR---EEESMREREKKMREEEEMMREQE 733
Query: 66 KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISL 125
+ ++ + E+++E E E +QE K+ Q + + P+ L
Sbjct: 734 EKMQEQEEKMQE--------QEEEMWEQEEKMWEQEEKMWEQQRLPEQKE--------KL 777
Query: 126 WKEKTNETFEEVIEKSKVVLNLIEKLK 152
W+ + + E++ E+ + + + EK++
Sbjct: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMR 804
Score = 37.7 bits (86), Expect = 0.038
Identities = 29/106 (27%), Positives = 56/106 (52%), Gaps = 12/106 (11%)
Query: 6 KKSGSKKKKVTKAERLKLLQE----EEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWH 61
KK+ ++KK E K+ +E E E++++EEEE + E++ E+ E + ++EK
Sbjct: 569 KKTQEQEKKTWDQEE-KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627
Query: 62 RLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ----WKH 103
E K E+ + E+ E+ + + EK+ ++ +L Q W+H
Sbjct: 628 EQEEKMQEQEEKMWEQ---EEKMWEQEEKMWEQQRLPEQKEKLWEH 670
Score = 37.7 bits (86), Expect = 0.038
Identities = 24/99 (24%), Positives = 53/99 (53%), Gaps = 2/99 (2%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEK-WHR 62
K ++ S +++ K + + E+E +++E+EE + E+E E+ E ++EK W +
Sbjct: 708 KMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 63 LEAKDLERRNEELEELYLLERCFPEAEKLK-QETKLLSQ 100
+ + + E E++ E+ + + EK++ QE K+ Q
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQ 806
Score = 33.9 bits (76), Expect = 0.54
Identities = 33/146 (22%), Positives = 69/146 (47%), Gaps = 15/146 (10%)
Query: 19 ERLKLLQEEEERRLKEEEEARLKYEK----------EEMERLEIQRIEKEK---WHRLEA 65
E+ + +QE+EE+ ++EE+ + + EK +E + E QR+ ++K W +
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 66 KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISL 125
++ E+ E+ E+++ E+ E + +QE K Q K + +E +
Sbjct: 674 QEQEKMQEQEEKIWEQEKM--EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
Query: 126 WKEKTNETFEEVIEKSKVVLNLIEKL 151
+EK E E++ E+ + + EK+
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKM 757
Score = 30.0 bits (66), Expect = 7.9
Identities = 25/127 (19%), Positives = 64/127 (50%), Gaps = 18/127 (14%)
Query: 3 PKAKKSGSKKKKVTKAERL-----KLLQEEEERRLKEE----EEARLKYEKEEM------ 47
P+ K+ + +K+ + E++ K+ +EE+ R +EE +E +++ ++E+M
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
Query: 48 ---ERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHY 104
+ ++ E++ W + E + + + +E + E+ + EK++++ + + +
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Query: 105 IQCDGSP 111
I C GSP
Sbjct: 891 IYCVGSP 897
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 51.2 bits (121), Expect = 3e-06
Identities = 83/358 (23%), Positives = 144/358 (40%), Gaps = 44/358 (12%)
Query: 26 EEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLE--R 83
E E RL+ EE R+K E+++ E RIE E+ + A++ ERR E E E R
Sbjct: 266 EAERARLEAEERERIKAEQDKKIADERARIEAEE--KAAAQERERREAEERERMREEEKR 323
Query: 84 CFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKV 143
E +++K+E K ++ + I+ + Q + E+ E EK+KV
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKV 383
Query: 144 V----LNLIEKLKFILLETP------PCDLQDK--NIIQYQESILQLQELLHLKFGVATE 191
+E+ K + ET ++ K N + QE LQ L T+
Sbjct: 384 EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443
Query: 192 ILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILAT 251
+ K+ D + E+ IKDE + K P+ F + + GF +
Sbjct: 444 VQAKREKLQEDKPTFKKEE-IKDEKI------KKDKEPKEEVKSFMDRKKGFTEVKSQNG 496
Query: 252 SDIAVRLLHTHYD--------HVSALHPVSTPSKEYTSAVTELVK----------DDVKN 293
+ +L HT V P E + EL + + +K
Sbjct: 497 EFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQ 556
Query: 294 VEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMK 351
++ + E+EE K++E +++EEE + ++E+ D +++ EEE +K E E +
Sbjct: 557 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR---EEEEKRRLKEEIERR 611
Score = 50.8 bits (120), Expect = 4e-06
Identities = 84/362 (23%), Positives = 147/362 (40%), Gaps = 31/362 (8%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 65
+K + K+ +AER +L EE ER +K E++ ++ E+ +E E + ++ R EA
Sbjct: 255 EKMEEEDKERAEAERARLEAEERER-IKAEQDKKIADERARIEAEE--KAAAQERERREA 311
Query: 66 KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISL 125
++ ER EE + R E +++K+E K ++ + I+ + Q +
Sbjct: 312 EERERMREEEK------RAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
Query: 126 WKEKTNETFEEVIEKSKVVLNL----IEKLKFILLETP------PCDLQDK--NIIQYQE 173
E+ E EK+KV +E+ K + ET ++ K N + QE
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQE 425
Query: 174 SILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRS 233
LQ L T++ K+ D + E+ IKDE + K P+
Sbjct: 426 DKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE-IKDEKI------KKDKEPKEEV 478
Query: 234 VRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKN 293
F + + GF + + +L HT S +KE A + K
Sbjct: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV---EAGKR 535
Query: 294 VEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVL 353
+E+ + E ES++ E+ QE +++EE + E + EEE + K E + L
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 354 SE 355
E
Sbjct: 596 RE 597
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/54 (40%), Positives = 33/54 (61%), Gaps = 2/54 (3%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEK 59
KK +++KV + E + QEE +R+L+EEEE R KEE+ER + EK +
Sbjct: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL--KEEIERRRAEAAEKRQ 620
Score = 39.7 bits (91), Expect = 0.010
Identities = 31/88 (35%), Positives = 49/88 (55%), Gaps = 12/88 (13%)
Query: 14 KVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNE 73
K + ER K+L+EEE+RR +EE + +L+ E+EE RL KE+ R A+ E+R +
Sbjct: 569 KKKREERRKVLEEEEQRRKQEEADRKLR-EEEEKRRL------KEEIERRRAEAAEKRQK 621
Query: 74 ELEELYLLE----RCF-PEAEKLKQETK 96
E+ + +CF P+ LK E +
Sbjct: 622 MPEDGLSDDKKPFKCFTPKGSSLKIEER 649
Score = 36.2 bits (82), Expect = 0.11
Identities = 25/77 (32%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 280 TSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE- 338
T + E V +KN + IS E ++ +++E+GS I E EE++ E + + E
Sbjct: 217 TESQEETVVMSLKNGQ--ISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEA 274
Query: 339 EESEAIKCEREMKVLSE 355
EE E IK E++ K+ E
Sbjct: 275 EERERIKAEQDKKIADE 291
Score = 36.2 bits (82), Expect = 0.11
Identities = 70/347 (20%), Positives = 146/347 (42%), Gaps = 48/347 (13%)
Query: 1 MGPKAKKSGSKKKKVTKAERLKLLQ----EEEERRLKEEEEARLKYEKEEMERLEIQRIE 56
M + K++ +++++ + E+ + +EEE+R EE + + EK E + R E
Sbjct: 317 MREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAE 376
Query: 57 KEKWHRLEAKDLERRNEELEE-LYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSV 115
+E+ ++E ++RN++LEE + ++ + EK++Q K+ +W +
Sbjct: 377 EEEKAKVEE---QKRNKQLEEKKHAMQETKIKGEKVEQ--KIEGKW---------VNEKK 422
Query: 116 AQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESI 175
AQE ++ K++ E +V K EKL+ +++D+ I + +E
Sbjct: 423 AQEDKLQTAVLKKQGEEKGTKVQAKR-------EKLQEDKPTFKKEEIKDEKIKKDKEPK 475
Query: 176 LQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVR 235
+++ + K G TE+ + + K+ EN + SV
Sbjct: 476 EEVKSFMDRKKGF-TEVKSQNGEFMT-------HKLKHTEN-------TFSRPGGRASVD 520
Query: 236 FSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVE 295
E + ++ ++ R T + L ++ A EL + K E
Sbjct: 521 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL------KQKQQEAALELEELKKKREE 574
Query: 296 KAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESE 342
+ E EE+ ++QE ++EEE K ++ +IE + + A E+ +
Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKE-EIERRRAEAAEKRQ 620
Score = 34.7 bits (78), Expect = 0.32
Identities = 70/350 (20%), Positives = 134/350 (38%), Gaps = 51/350 (14%)
Query: 35 EEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLE---RCFPEAEKL 91
E L+ +K E RLE +RI + RN++ EE E R E +
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQ------------RNDDDEEEAARERRRRARQERLRQ 52
Query: 92 KQETKLLSQWKHYIQCDGS---PDPSV-AQEMNTFI------------SLWKEKTNETFE 135
KQE + L Q ++ + PD NT + + +E+ + +
Sbjct: 53 KQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ 112
Query: 136 EVIEKSKVVLNLIEKLKFIL-LETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILL 194
E +E+ K I L D + + +E QE ++ TE +
Sbjct: 113 EALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE---ETETVT 169
Query: 195 K--QASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATS 252
K Q + D + E K+E ++ P+ S+ E Q+ + S
Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEE--------EEKPKRGSI--GENQVEVMVEEKTTES 219
Query: 253 DIAVRLLHTHYDHVSALHPVSTPSKEYTS-AVTELVKDDVKNVEKAISKEVEEESKQQER 311
++ +S+ P +E S ++ K + ++ E+A ++ E++++ER
Sbjct: 220 QEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERER 279
Query: 312 GSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQ 361
+ E++ K+ +E+ IE + +A +E E + E ++ E AA+
Sbjct: 280 ---IKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326
Score = 33.5 bits (75), Expect = 0.71
Identities = 19/56 (33%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEK 59
K + +++K +A+R KL +EEE+RRLKEE E R E+ +++ + +K
Sbjct: 577 KVLEEEEQRRKQEEADR-KLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
Score = 30.0 bits (66), Expect = 7.9
Identities = 21/78 (26%), Positives = 34/78 (43%)
Query: 285 ELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAI 344
E ++++ K + + EEE + E + +EE+ EE Q E + +AEE A
Sbjct: 315 ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRAR 374
Query: 345 KCEREMKVLSETVSAAQL 362
E E + E QL
Sbjct: 375 AEEEEKAKVEEQKRNKQL 392
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 50.8 bits (120), Expect = 4e-06
Identities = 84/394 (21%), Positives = 167/394 (42%), Gaps = 41/394 (10%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEME-------RLEIQRIEKE 58
+K K + R+K EEE+ R++E EE RL +KE +E R + +E E
Sbjct: 722 QKKALAKSITQEKNRVKEALEEEQTRVQELEE-RLARQKEVLESSIAHEKRKAKEALESE 780
Query: 59 KW-------HRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSP 111
K H + K++ N E+ E E +K++ L++ K ++
Sbjct: 781 KRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQK 840
Query: 112 DPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQY 171
+ + +++ +++ +E E ++ + L L E L + + ++ +I
Sbjct: 841 EDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQ 900
Query: 172 QESILQLQ-ELLHLKFGVATEIL-----LKQ-ASTLADLDSGNMEKVIKDENVTLYVWAN 224
Q+ + LQ E + G EI+ +KQ A T+ L+ ++KV + A
Sbjct: 901 QKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEE-KLQKVTQHHKKIEGEIAT 959
Query: 225 LKKN-PRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAV 283
LK N P + R + P + ++ + + Y+H+ + + KE S
Sbjct: 960 LKDNDPAPKEERPQD-------PLVAPMTESSAK--DMAYEHL--IDDLLAAQKEILSQ- 1007
Query: 284 TELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEV-KMSSAEEESE 342
E++ K++ +A S+ + + E+ +++ + V+++ ++ V K A+ S
Sbjct: 1008 QEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
Query: 343 AIKCEREMKVLSETVSAAQ----LLLVENSSEKP 372
K +RE+K L E + A+Q L L +KP
Sbjct: 1068 VEKKDRELKALEEALRASQEKHRLQLNTEKEQKP 1101
Score = 37.7 bits (86), Expect = 0.038
Identities = 100/416 (24%), Positives = 161/416 (38%), Gaps = 75/416 (18%)
Query: 12 KKKVTKAE-RLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLER 70
+K +T+A R+ L+ E + K E E + +++ + L + KEK ++ + +E+
Sbjct: 1015 RKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVL---KEKMAQMSSL-VEK 1070
Query: 71 RNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQ-CDGSP--DP------SVAQEMNT 121
++ EL+ L R E +L+ T+ + + Q CD S +P S +QE +
Sbjct: 1071 KDRELKALEEALRASQEKHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQEQQS 1130
Query: 122 FISLWKEKTNETFEEVIEKSKVVLN-LIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 180
F L EEVI++ K L+ L ++K + P +N ES L L+
Sbjct: 1131 FSDLGVRCKGSRHEEVIQRQKKALSELRARIKELEKARSPDHKDHQN-----ESFLDLKN 1185
Query: 181 ----------LLHLKFGVAT----EILLKQASTL------ADLDSGNM---------EKV 211
LL K + T EIL Q A SG M EK+
Sbjct: 1186 LRMENNVQKILLDAKPDLPTLSRIEILAPQNGLCNARFGSAMEKSGKMDVAEALELSEKL 1245
Query: 212 IKDENVTLYVWANLKKNPRHRSVRFSETQ---------------IGFEIPRILATSDIAV 256
D + TL N+K H S+++ Q + +I ++
Sbjct: 1246 YLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLRQRDLDLVFDKITQLKNQLGRKE 1305
Query: 257 RLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNV-EKAISKEVEEESKQQERGSHL 315
LL + V L + Y S V +L D K EKA+ KE E + Q L
Sbjct: 1306 ELLRGYEKDVEQLRRSKVSIEMYQSQVAKLEDDIYKEAEEKALLKEALERMEHQ-----L 1360
Query: 316 IQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSSEK 371
QE+ I Q + + +S + + EREM + ++Q LL S K
Sbjct: 1361 CQEKRINRAIRQQKVGTRKASLKMDQ-----EREMLRKETSSKSSQSLLHSKPSGK 1411
Score = 33.1 bits (74), Expect = 0.93
Identities = 34/150 (22%), Positives = 73/150 (48%), Gaps = 14/150 (9%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 63
KAK++ K+KK + +L +++EE LKE++E L + + + + + + L
Sbjct: 808 KAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESL 867
Query: 64 EAKDLE-RRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 122
+A+ L + NE L EL + + + E +L+ Q K ++ E +
Sbjct: 868 KAESLALKLNETLAELET-----TKTKMIMVEERLILQQKMV--------KALQDEQESQ 914
Query: 123 ISLWKEKTNETFEEVIEKSKVVLNLIEKLK 152
++E+ E E++ + ++ +++L EKL+
Sbjct: 915 RHGFEEEIMEYKEQIKQHAQTIVSLEEKLQ 944
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/97 (28%), Positives = 58/97 (59%), Gaps = 4/97 (4%)
Query: 5 AKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERL--EIQRIEKEKWHR 62
A+K ++KK + E K +EEE R +E EA L+ ++EE R E++ ++K +
Sbjct: 813 AEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEA 872
Query: 63 LEAKDLERR--NEELEELYLLERCFPEAEKLKQETKL 97
++LE++ N+++EE+ LE+ + +++K++ +L
Sbjct: 873 ELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQEL 909
Score = 33.1 bits (74), Expect = 0.93
Identities = 21/66 (31%), Positives = 39/66 (59%), Gaps = 4/66 (6%)
Query: 297 AISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSET 356
A +E EE+ KQ+E +EEE + E E+ + E++ A++E E K ++E++ L ++
Sbjct: 813 AEKREQEEKKKQEEEEKKKREEEERERERERREAELR---AQQEEETRK-QQELEALQKS 868
Query: 357 VSAAQL 362
A+L
Sbjct: 869 QKEAEL 874
>gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo
sapiens]
Length = 619
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 17/181 (9%)
Query: 19 ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEEL 78
E L+L + +E EEEE K +EE E E + + + H +A L +E
Sbjct: 251 ELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEE-DLQCAHPCDAPKLIS-----QEA 304
Query: 79 YLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVI 138
L + P+ E L+++ +LL + H ++ + S ++ E I E+ +E +++
Sbjct: 305 LLHQHHCPQLEALQEKLRLLEEENHQLREEASQLDTLEDEEQMLILECVEQFSEASQQMA 364
Query: 139 EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQAS 198
E S+V++ +E + Q + + + Q +L+LQ+ + +G TE L KQ +
Sbjct: 365 ELSEVLVLRLENY----------ERQQQEVARLQAQVLKLQQRCRM-YGAETEKLQKQLA 413
Query: 199 T 199
+
Sbjct: 414 S 414
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 48.5 bits (114), Expect = 2e-05
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKY-EKEEMERLE---IQRIEKEK 59
KAK+ ++K K K ++E E RR +EEE RL++ ++EE ER +Q+ ++E+
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 671
Query: 60 WHRL----------EAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDG 109
RL E ++ ERR +E E E+ E E+ +QE +L Q + Q +
Sbjct: 672 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ-ER 730
Query: 110 SPDPSVAQEMNTFISLWKEKTNETFEEVIEKSK 142
QE + L KE+ EE +K +
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEE 763
Score = 37.7 bits (86), Expect = 0.038
Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 24/113 (21%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI-------- 55
K ++ + +K +A+RL +E+E R + E+ R + E+ E ER E +R
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726
Query: 56 ------------EKEKWHRLEAKDLERRNEEL----EELYLLERCFPEAEKLK 92
E+EK RL+ + L+R EE E+ L ER E ++ K
Sbjct: 727 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 779
Score = 35.8 bits (81), Expect = 0.14
Identities = 30/120 (25%), Positives = 65/120 (54%), Gaps = 27/120 (22%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKE------------------EEEARLKYEKE 45
K K+ +K + ER++ ++EE+++++++ EE+A+ K +
Sbjct: 571 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 630
Query: 46 EMERLEIQRIEKEKWHR---LEAKDLERRNEELEELYLLERCFPEAEKLKQ--ETKLLSQ 100
+ME +E +R ++E+ R L+ ++ ERR++EL L ++ E E+L++ E K L++
Sbjct: 631 KMEEVEARRKQEEEARRLRWLQQEEEERRHQEL----LQKKKEEEQERLRKAAEAKRLAE 686
Score = 35.0 bits (79), Expect = 0.24
Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 6/65 (9%)
Query: 34 EEEEARLKY--EKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKL 91
E+E RL+ KEE E+L Q++E++K RLE L+R + L ER E++
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER----VEQM 591
Query: 92 KQETK 96
K+E K
Sbjct: 592 KEEKK 596
Score = 32.0 bits (71), Expect = 2.1
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 13/81 (16%)
Query: 284 TELVKDDVKNVEKAISK-------EVEEESKQQERGSHL--IQEEEIKVEEEQGDIEVKM 334
TE K++ EKA K EVE KQ+E L +Q+EE EE+ E+
Sbjct: 610 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE----EERRHQELLQ 665
Query: 335 SSAEEESEAIKCEREMKVLSE 355
EEE E ++ E K L+E
Sbjct: 666 KKKEEEQERLRKAAEAKRLAE 686
Score = 31.2 bits (69), Expect = 3.5
Identities = 26/103 (25%), Positives = 53/103 (51%), Gaps = 18/103 (17%)
Query: 12 KKKVTKAERLKLLQEEEE-RRLKEEEEARLKYEKEEMERLE-----------IQRIEKEK 59
+K+ + E L+ +E E+ RR K EE+ R + E+ +++R E ++++++EK
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 595
Query: 60 WHRLEAK--DLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 100
++E K ++ + E+ +E ER E K K K + +
Sbjct: 596 KKQIEQKFAQIDEKTEKAKE----ERLAEEKAKKKAAAKKMEE 634
Score = 30.8 bits (68), Expect = 4.6
Identities = 26/107 (24%), Positives = 60/107 (56%), Gaps = 11/107 (10%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEER--RLKEEEEARLKYE----KEEMERLEIQRIEKEK 59
K+ ++ K+ + ERL+ + + ER ++KEE++ +++ + E+ E+ + +R+ +EK
Sbjct: 563 KRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 622
Query: 60 WHRLEA----KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWK 102
+ A +++E R ++ EE L R + E+ ++ +LL + K
Sbjct: 623 AKKKAAAKKMEEVEARRKQEEEARRL-RWLQQEEEERRHQELLQKKK 668
Score = 30.4 bits (67), Expect = 6.0
Identities = 20/78 (25%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 296 KAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE--EESEAIKCEREMKVL 353
K ++++ E+E ++QER +E+E + E+E+ + E +++ E E E ++ ERE++
Sbjct: 682 KRLAEQREQERREQERREQERREQE-RREQERREQERQLAEQERRREQERLQAERELQER 740
Query: 354 SETVSAAQLLLVENSSEK 371
+ + + L EK
Sbjct: 741 EKALRLQKEQLQRELEEK 758
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 48.5 bits (114), Expect = 2e-05
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 15/153 (9%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKY-EKEEMERLE---IQRIEKEK 59
KAK+ ++K K K ++E E RR +EEE RL++ ++EE ER +Q+ ++E+
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 667
Query: 60 WHRL----------EAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDG 109
RL E ++ ERR +E E E+ E E+ +QE +L Q + Q +
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQ-ER 726
Query: 110 SPDPSVAQEMNTFISLWKEKTNETFEEVIEKSK 142
QE + L KE+ EE +K +
Sbjct: 727 LQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
Score = 37.7 bits (86), Expect = 0.038
Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 24/113 (21%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRI-------- 55
K ++ + +K +A+RL +E+E R + E+ R + E+ E ER E +R
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 722
Query: 56 ------------EKEKWHRLEAKDLERRNEEL----EELYLLERCFPEAEKLK 92
E+EK RL+ + L+R EE E+ L ER E ++ K
Sbjct: 723 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKK 775
Score = 37.0 bits (84), Expect = 0.064
Identities = 25/66 (37%), Positives = 37/66 (56%), Gaps = 6/66 (9%)
Query: 33 KEEEEARLKY--EKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEK 90
KE+E RL+ KEE E+L Q++E++K RLE L+R + L ER E+
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER----VEQ 586
Query: 91 LKQETK 96
+K+E K
Sbjct: 587 MKEEKK 592
Score = 35.8 bits (81), Expect = 0.14
Identities = 30/120 (25%), Positives = 65/120 (54%), Gaps = 27/120 (22%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKE------------------EEEARLKYEKE 45
K K+ +K + ER++ ++EE+++++++ EE+A+ K +
Sbjct: 567 KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 626
Query: 46 EMERLEIQRIEKEKWHR---LEAKDLERRNEELEELYLLERCFPEAEKLKQ--ETKLLSQ 100
+ME +E +R ++E+ R L+ ++ ERR++EL L ++ E E+L++ E K L++
Sbjct: 627 KMEEVEARRKQEEEARRLRWLQQEEEERRHQEL----LQKKKEEEQERLRKAAEAKRLAE 682
Score = 33.1 bits (74), Expect = 0.93
Identities = 27/104 (25%), Positives = 54/104 (51%), Gaps = 18/104 (17%)
Query: 11 KKKKVTKAERLKLLQEEEE-RRLKEEEEARLKYEKEEMERLE-----------IQRIEKE 58
K+K+ + E L+ +E E+ RR K EE+ R + E+ +++R E ++++++E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 59 KWHRLEAK--DLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 100
K ++E K ++ + E+ +E ER E K K K + +
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKE----ERLAEEKAKKKAAAKKMEE 630
Score = 32.0 bits (71), Expect = 2.1
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 13/81 (16%)
Query: 284 TELVKDDVKNVEKAISK-------EVEEESKQQERGSHL--IQEEEIKVEEEQGDIEVKM 334
TE K++ EKA K EVE KQ+E L +Q+EE EE+ E+
Sbjct: 606 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE----EERRHQELLQ 661
Query: 335 SSAEEESEAIKCEREMKVLSE 355
EEE E ++ E K L+E
Sbjct: 662 KKKEEEQERLRKAAEAKRLAE 682
Score = 30.8 bits (68), Expect = 4.6
Identities = 26/107 (24%), Positives = 60/107 (56%), Gaps = 11/107 (10%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEER--RLKEEEEARLKYE----KEEMERLEIQRIEKEK 59
K+ ++ K+ + ERL+ + + ER ++KEE++ +++ + E+ E+ + +R+ +EK
Sbjct: 559 KRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 618
Query: 60 WHRLEA----KDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWK 102
+ A +++E R ++ EE L R + E+ ++ +LL + K
Sbjct: 619 AKKKAAAKKMEEVEARRKQEEEARRL-RWLQQEEEERRHQELLQKKK 664
Score = 30.4 bits (67), Expect = 6.0
Identities = 20/78 (25%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Query: 296 KAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE--EESEAIKCEREMKVL 353
K ++++ E+E ++QER +E+E + E+E+ + E +++ E E E ++ ERE++
Sbjct: 678 KRLAEQREQERREQERREQERREQE-RREQERREQERQLAEQERRREQERLQAERELQER 736
Query: 354 SETVSAAQLLLVENSSEK 371
+ + + L EK
Sbjct: 737 EKALRLQKEQLQRELEEK 754
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 48.1 bits (113), Expect = 3e-05
Identities = 70/364 (19%), Positives = 157/364 (43%), Gaps = 27/364 (7%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 63
+ ++ ++++ + E K L+++ E + EEE R + E+ E + E++R + +W R
Sbjct: 393 RKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERN 452
Query: 64 EAKD-LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 122
++ L +RN+E E++ +L+ + + L+ E + L+ KH ++ Q++
Sbjct: 453 RRQELLNQRNKEQEDIVVLK---AKKKTLEFELEALNDKKHQLE-------GKLQDIRCR 502
Query: 123 ISLWK---EKTNETFE-EVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL 178
++ + E TN++ E + E + + L E + + P + + + Q Q++ L
Sbjct: 503 LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHR 562
Query: 179 QELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSE 238
L+ LK + + L +Q LD E K + + ++ LK+ + + +
Sbjct: 563 DSLVTLKRALEAKELARQ-HLRDQLDEVEKETRSKLQEIDIFN-NQLKELREIHNKQQLQ 620
Query: 239 TQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTE---------LVKD 289
Q E R L + +++ A K++ V + L ++
Sbjct: 621 KQKSMEAER-LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 290 DVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCERE 349
+ E+++ K+ EE +QE L + E + ++ S+AE+ I +
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 350 MKVL 353
+KV+
Sbjct: 740 VKVV 743
Score = 39.7 bits (91), Expect = 0.010
Identities = 75/352 (21%), Positives = 152/352 (43%), Gaps = 54/352 (15%)
Query: 13 KKVTKAERLKLLQEEEERRLKE----EEEARLKYEKEEMERLEIQRIEKEKWHRLE---- 64
KK ER L E+ + L E E+E + E+ E ER E +R E+E+ +LE
Sbjct: 353 KKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ 412
Query: 65 ---AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 121
++LER+ EE E +ER EA K + E + +W+ + + + QE
Sbjct: 413 LEKQRELERQREE-ERRKEIER--REAAKRELERQRQLEWERNRRQELLNQRNKEQEDIV 469
Query: 122 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 181
+ K+ E + +K + ++ ++ L T +++ N + L++ E+
Sbjct: 470 VLKAKKKTLEFELEALNDKKHQLEGKLQDIR-CRLTTQRQEIESTN----KSRELRIAEI 524
Query: 182 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 241
HL + L+++ + + ++I ++ + +++N HR +
Sbjct: 525 THL------QQQLQESQQM-------LGRLIPEKQILNDQLKQVQQNSLHRDSLVT---- 567
Query: 242 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 301
+ R L ++A + L D V KE S + E+ D+ N + +E
Sbjct: 568 ---LKRALEAKELARQHLRDQLDEV---------EKETRSKLQEI---DIFNNQLKELRE 612
Query: 302 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVL 353
+ +KQQ + ++ E +K +E++ I +++ +EE++ ER+ + L
Sbjct: 613 I--HNKQQLQKQKSMEAERLKQKEQERKI-IELEKQKEEAQRRAQERDKQWL 661
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 48.1 bits (113), Expect = 3e-05
Identities = 70/364 (19%), Positives = 157/364 (43%), Gaps = 27/364 (7%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 63
+ ++ ++++ + E K L+++ E + EEE R + E+ E + E++R + +W R
Sbjct: 393 RKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERN 452
Query: 64 EAKD-LERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 122
++ L +RN+E E++ +L+ + + L+ E + L+ KH ++ Q++
Sbjct: 453 RRQELLNQRNKEQEDIVVLK---AKKKTLEFELEALNDKKHQLE-------GKLQDIRCR 502
Query: 123 ISLWK---EKTNETFE-EVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL 178
++ + E TN++ E + E + + L E + + P + + + Q Q++ L
Sbjct: 503 LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHR 562
Query: 179 QELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSE 238
L+ LK + + L +Q LD E K + + ++ LK+ + + +
Sbjct: 563 DSLVTLKRALEAKELARQ-HLRDQLDEVEKETRSKLQEIDIFN-NQLKELREIHNKQQLQ 620
Query: 239 TQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTE---------LVKD 289
Q E R L + +++ A K++ V + L ++
Sbjct: 621 KQKSMEAER-LKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEE 679
Query: 290 DVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCERE 349
+ E+++ K+ EE +QE L + E + ++ S+AE+ I +
Sbjct: 680 EKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQEN 739
Query: 350 MKVL 353
+KV+
Sbjct: 740 VKVV 743
Score = 39.7 bits (91), Expect = 0.010
Identities = 75/352 (21%), Positives = 152/352 (43%), Gaps = 54/352 (15%)
Query: 13 KKVTKAERLKLLQEEEERRLKE----EEEARLKYEKEEMERLEIQRIEKEKWHRLE---- 64
KK ER L E+ + L E E+E + E+ E ER E +R E+E+ +LE
Sbjct: 353 KKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQ 412
Query: 65 ---AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNT 121
++LER+ EE E +ER EA K + E + +W+ + + + QE
Sbjct: 413 LEKQRELERQREE-ERRKEIER--REAAKRELERQRQLEWERNRRQELLNQRNKEQEDIV 469
Query: 122 FISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQEL 181
+ K+ E + +K + ++ ++ L T +++ N + L++ E+
Sbjct: 470 VLKAKKKTLEFELEALNDKKHQLEGKLQDIR-CRLTTQRQEIESTN----KSRELRIAEI 524
Query: 182 LHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQI 241
HL + L+++ + + ++I ++ + +++N HR +
Sbjct: 525 THL------QQQLQESQQM-------LGRLIPEKQILNDQLKQVQQNSLHRDSLVT---- 567
Query: 242 GFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKE 301
+ R L ++A + L D V KE S + E+ D+ N + +E
Sbjct: 568 ---LKRALEAKELARQHLRDQLDEV---------EKETRSKLQEI---DIFNNQLKELRE 612
Query: 302 VEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVL 353
+ +KQQ + ++ E +K +E++ I +++ +EE++ ER+ + L
Sbjct: 613 I--HNKQQLQKQKSMEAERLKQKEQERKI-IELEKQKEEAQRRAQERDKQWL 661
>gi|116174778 centrosome spindle pole associated protein 1 isoform b
[Homo sapiens]
Length = 1221
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/191 (26%), Positives = 92/191 (48%), Gaps = 25/191 (13%)
Query: 11 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-----MERLEIQRIEKEKWHRL-- 63
K+++ + ERL++ +E+EERRL E+ AR++ E EE E+ E QR++ E+ RL
Sbjct: 747 KQREEAERERLRIAEEKEERRL-AEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAE 805
Query: 64 -EAKDLERRNEELEELYLLE---------RCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 113
K+ ER+ +E EE Y L+ E + ++Q + ++ ++ I P
Sbjct: 806 ERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPP 865
Query: 114 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 173
SV + +FI + + + K L E+ K +++E Q ++ +E
Sbjct: 866 SVDSIIRSFIH--ESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQ----LRSEE 919
Query: 174 SILQLQELLHL 184
LQ + LLH+
Sbjct: 920 RRLQ-ERLLHM 929
Score = 40.8 bits (94), Expect = 0.004
Identities = 39/171 (22%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 25 QEEEERRLKEEEEARLKYEKEEME------RLEIQRIEKEKWHRLEAKDLERRNEELEEL 78
Q EE+++ +E E RL+ +E+ E R IQ+ +E+ + K+ E+R + E +
Sbjct: 742 QIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHI 801
Query: 79 YLLERCFPEAEKLK--QETKLLSQWKHYIQCDG--SPDPSVAQEMNTFISLWKEKTNETF 134
L E EAE+ K +E K Q +HY + D + ++ + + + K
Sbjct: 802 RLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKL 861
Query: 135 EEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQES----ILQLQEL 181
+ ++ + I + ++PP + KN ++ +E I++L E+
Sbjct: 862 QRPPSVDSIIRSFIHESSMSRAQSPPVPAR-KNQLRAEEEKKNVIMELSEM 911
>gi|116174789 centrosome spindle pole associated protein 1 isoform a
[Homo sapiens]
Length = 1256
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/191 (26%), Positives = 92/191 (48%), Gaps = 25/191 (13%)
Query: 11 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEE-----MERLEIQRIEKEKWHRL-- 63
K+++ + ERL++ +E+EERRL E+ AR++ E EE E+ E QR++ E+ RL
Sbjct: 782 KQREEAERERLRIAEEKEERRL-AEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAE 840
Query: 64 -EAKDLERRNEELEELYLLE---------RCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 113
K+ ER+ +E EE Y L+ E + ++Q + ++ ++ I P
Sbjct: 841 ERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPP 900
Query: 114 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 173
SV + +FI + + + K L E+ K +++E Q ++ +E
Sbjct: 901 SVDSIIRSFIH--ESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQ----LRSEE 954
Query: 174 SILQLQELLHL 184
LQ + LLH+
Sbjct: 955 RRLQ-ERLLHM 964
Score = 40.8 bits (94), Expect = 0.004
Identities = 39/171 (22%), Positives = 78/171 (45%), Gaps = 15/171 (8%)
Query: 25 QEEEERRLKEEEEARLKYEKEEME------RLEIQRIEKEKWHRLEAKDLERRNEELEEL 78
Q EE+++ +E E RL+ +E+ E R IQ+ +E+ + K+ E+R + E +
Sbjct: 777 QIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHI 836
Query: 79 YLLERCFPEAEKLK--QETKLLSQWKHYIQCDG--SPDPSVAQEMNTFISLWKEKTNETF 134
L E EAE+ K +E K Q +HY + D + ++ + + + K
Sbjct: 837 RLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKL 896
Query: 135 EEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQES----ILQLQEL 181
+ ++ + I + ++PP + KN ++ +E I++L E+
Sbjct: 897 QRPPSVDSIIRSFIHESSMSRAQSPPVPAR-KNQLRAEEEKKNVIMELSEM 946
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 47.8 bits (112), Expect = 4e-05
Identities = 56/230 (24%), Positives = 104/230 (45%), Gaps = 16/230 (6%)
Query: 19 ERLKLLQE---EEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLE---AKDLERRN 72
ERL+ +E E+E RL+E EE + E+ E+ E R ++E+ H E + ER
Sbjct: 234 ERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLR 293
Query: 73 EELEELYLLERCFPEAEK--LKQETKLLSQWKHYIQCDGSP-DPSVAQEMNTFISLWKEK 129
E+ E L E E E+ +QE +L Q + + + P + +E+ + +E+
Sbjct: 294 EQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLE--QER 351
Query: 130 TNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVA 189
E E ++E+ +++ + E L+ L L + +Q E + +L+ +L L +
Sbjct: 352 RQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLELGWEAL 411
Query: 190 TEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSET 239
E + S +L++ N + ++ V LKK+ R SE+
Sbjct: 412 YEQRAEPRSGFEELNNENKSTLQLEQQV-----KELKKSGGAEEPRGSES 456
Score = 37.0 bits (84), Expect = 0.064
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 14 KVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNE 73
+V + L LL +E RL+E+EE RL+ ++E + E + E+E+ R + + L + E
Sbjct: 183 EVENNQMLSLLNRRQEERLREQEE-RLREQEERLREQEERLCEQEERLREQEERLREQEE 241
Query: 74 ELEELYLLERCFPEAEKL-KQETKLLSQ 100
L E ER E+L +QE +L Q
Sbjct: 242 RLCEQE--ERLREHEERLCEQEERLCEQ 267
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/77 (41%), Positives = 44/77 (57%), Gaps = 7/77 (9%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRL-----KEEEEARLKYEKEEMERLEIQRIEKEKW 60
+K KKKK + E+ K +EEE++R K+EEE R + E+EE E E + EKE+
Sbjct: 37 RKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEE--EKEEG 94
Query: 61 HRLEAKDLERRNEELEE 77
R + K RR EE EE
Sbjct: 95 RRRKKKKKRRRKEEEEE 111
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/96 (29%), Positives = 53/96 (55%), Gaps = 3/96 (3%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYE---KEEMERLEIQRIEKEKW 60
+ K+ +K+K + E+ K +E E+R+ KEEEE + K + K+E E E + E+E+
Sbjct: 26 EGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEE 85
Query: 61 HRLEAKDLERRNEELEELYLLERCFPEAEKLKQETK 96
E K+ RR ++ ++ E + +K +++TK
Sbjct: 86 KEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTK 121
Score = 40.0 bits (92), Expect = 0.008
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEA 65
KK KKK+ + E + +EEEE+ K +E+ + K KE+ ++ + + EK K E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEK-RKEKEKKKKTKETEKRKEKEEEE 59
Query: 66 KDLERRNEELEELYLLERCFPEAEKLKQE 94
K +R+ ++ +E E E E+ K+E
Sbjct: 60 KKRKRKRKKKKEEEEREEEEEEEEEEKEE 88
Score = 36.6 bits (83), Expect = 0.084
Identities = 21/63 (33%), Positives = 35/63 (55%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 63
K +K KKKK + + +EEEE+ +E+EE R + +K++ R E + +K+K R
Sbjct: 60 KKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
Query: 64 EAK 66
K
Sbjct: 120 TKK 122
Score = 34.7 bits (78), Expect = 0.32
Identities = 21/68 (30%), Positives = 42/68 (61%), Gaps = 1/68 (1%)
Query: 11 KKKKVTKAERLKLLQEEEERRLK-EEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLE 69
++K+ + E+ K ++E+E++ K +E E R + E+EE +R ++ +KE+ R E ++ E
Sbjct: 23 EEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEE 82
Query: 70 RRNEELEE 77
+E EE
Sbjct: 83 EEEKEEEE 90
Score = 34.3 bits (77), Expect = 0.42
Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 288 KDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCE 347
K K EK KE EEE K+++R +EEE + EEE+ + E K +EE K +
Sbjct: 43 KKKTKETEKR--KEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK 100
Query: 348 REMK 351
++ +
Sbjct: 101 KKRR 104
Score = 30.0 bits (66), Expect = 7.9
Identities = 19/63 (30%), Positives = 35/63 (55%), Gaps = 10/63 (15%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEE----------RRLKEEEEARLKYEKEEMERLEIQRI 55
K+ +KKK + ER + +EEEE RR K++++ R K E+EE ++ ++
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKT 120
Query: 56 EKE 58
+K+
Sbjct: 121 KKK 123
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 47.4 bits (111), Expect = 5e-05
Identities = 83/368 (22%), Positives = 168/368 (45%), Gaps = 62/368 (16%)
Query: 20 RLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELY 79
R + + E + R E E + KE+ ++ + KE+ R D++ RNEE+E+L
Sbjct: 2099 RFQPISEHQTR----EVEQLANHLKEKTDKCSELLLSKEQLQR----DIQERNEEIEKLE 2150
Query: 80 LLERCFPEAEKLKQET-KLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVI 138
R +A + +T + + KH+ + P E++ + L E+ + +
Sbjct: 2151 FRVRELEQALLVSADTFQKVEDRKHFGAVEAKP------ELSLEVQLQAER-----DAID 2199
Query: 139 EKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQAS 198
K K + NL E+L+ E L++KN E + QL L EI K+++
Sbjct: 2200 RKEKEITNLEEQLEQFREE-----LENKN-----EEVQQLHMQL--------EIQKKEST 2241
Query: 199 T-LADLDSGNMEKVIKD--ENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIA 255
T L +L+ N K+ KD E + L + + + + + V F + +I+ ++
Sbjct: 2242 TRLQELEQEN--KLFKDDMEKLGLAIKESDAMSTQDQHVLFG------KFAQIIQEKEVE 2293
Query: 256 VRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHL 315
+ L+ + ++T +K EL++D +E +S ++E ++ R +
Sbjct: 2294 IDQLNEQVTKLQQQLKITTDNK-VIEEKNELIRDLETQIECLMS---DQECVKRNREEEI 2349
Query: 316 IQEEEI--KVEEEQGDIEVKMS----SAEEESEAIKCEREMKVLSETVSAAQLLLVENSS 369
Q E+ K+++E +I K S S EE++++K + ++ V++E ++ Q VE ++
Sbjct: 2350 EQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDV-VIAEKLALEQ--QVETAN 2406
Query: 370 EKPDFFED 377
E+ F ++
Sbjct: 2407 EEMTFMKN 2414
Score = 37.0 bits (84), Expect = 0.064
Identities = 43/219 (19%), Positives = 92/219 (42%), Gaps = 33/219 (15%)
Query: 162 DLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYV 221
+L++ + E + QLQE E +KQ + + N+++ ++++ T+
Sbjct: 177 ELEEMRVTYGTEGLQQLQEF---------EAAIKQRDGIITQLTANLQQARREKDETMRE 227
Query: 222 WANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLH------THYDHVSA----LHP 271
+ L + + ++F + Q E R S A LL TH + L
Sbjct: 228 FLELTEQSQKLQIQFQQLQAS-ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286
Query: 272 VSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIE 331
+++T ++ L ++ +K E K+VE +K++ IQE+E +E E
Sbjct: 287 YQKKKEDFTMQISFL-QEKIKVYEMEQDKKVENSNKEE------IQEKETIIE------E 333
Query: 332 VKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSSE 370
+ EEE + ++ + ++ + + Q +V+ + E
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Score = 37.0 bits (84), Expect = 0.064
Identities = 48/197 (24%), Positives = 93/197 (47%), Gaps = 34/197 (17%)
Query: 23 LLQEEEERRLKEEE--EARLKYEKEEMERLEIQRIEKEKWHRLEAKD--LERRNEELEEL 78
L QEE+E+ E+E E +LK E E + E + +EK+ +LEA++ L+ + LE++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM 790
Query: 79 YLLERCFPEAEKL------KQETKLLSQWKHYI------------QCDGSPDPSVAQEMN 120
+ + E+L K ++K S W+ I QC + + ++ N
Sbjct: 791 LKIHTPVSQEERLIFLDSIKSKSK-DSVWEKEIEILIEENEDLKQQCI-QLNEEIEKQRN 848
Query: 121 TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 180
TF S ++ ++E+ E+ +L + + L+ D ++K ++Y+ + L E
Sbjct: 849 TF-SFAEKNFEVNYQELQEEYACLLKVKDDLE---------DSKNKQELEYKSKLKALNE 898
Query: 181 LLHLKFGVATEILLKQA 197
LHL+ T + +K +
Sbjct: 899 ELHLQRINPTTVKMKSS 915
Score = 37.0 bits (84), Expect = 0.064
Identities = 79/397 (19%), Positives = 154/397 (38%), Gaps = 65/397 (16%)
Query: 37 EARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYL-----LERCFPEAEKL 91
E +L+ E++ ++R E + E+ ++LE +NEE+++L++ + ++L
Sbjct: 2188 EVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2247
Query: 92 KQETKLLSQWKHYI-QCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEK 150
+QE KL + D Q+ + + + E E+ + ++ V L ++
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQ 2307
Query: 151 LKFIL--------------LETP-PCDLQDKNIIQ--YQESILQLQELLH------LKFG 187
LK LET C + D+ ++ +E I QL E++ G
Sbjct: 2308 LKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2367
Query: 188 VATEILLKQASTLADLDSGNMEKVIKDE----------NVTLYVWANLKKNPRHRSVRFS 237
T + S AD ++ VI ++ N + N+ K + + +
Sbjct: 2368 QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLT 2427
Query: 238 ETQIGFEIPR--ILATSDIAVRLLHTHYDHVSALHP-----------VSTPSKEYTSAVT 284
+ + R + I ++ DH+S P S ++ Y +
Sbjct: 2428 QELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE 2487
Query: 285 ELVKDDVKNVEKAISKEVEEESKQQERGSHLIQ-EEEIKVEEEQGDIEVKMSSAEEESEA 343
E K + N+E ++ ++ ES + L Q ++IK +EQG E +M
Sbjct: 2488 ENGKGSIINLE---TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK------ 2538
Query: 344 IKCEREMKVLSETVSAAQL--LLVENSSEKPDFFEDN 378
K K++ E V+AA + + +E E F +DN
Sbjct: 2539 -KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
Score = 35.8 bits (81), Expect = 0.14
Identities = 62/330 (18%), Positives = 133/330 (40%), Gaps = 26/330 (7%)
Query: 19 ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKD-LERRNEELEE 77
E++K+ + E++++++ + ++ ++ +E L + IE+EK LE KD L ++ L E
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEK-KTLELKDKLTTADKLLGE 361
Query: 78 LYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEV 137
L E+ + +++K L+ K Q + + Q M T L K ++ E
Sbjct: 362 LQ--EQIVQKNQEIKNMKLELTNSK---QKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 138 IEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQL-QELLHLKFGVATEILLKQ 196
++ KL+ + E Y + I+Q+ QEL+ E+ +
Sbjct: 417 DIVQRMEQETQRKLEQLRAELDE---------MYGQQIVQMKQELIRQHMAQMEEMKTRH 467
Query: 197 ASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAV 256
+ + + ++ + L A + N + + + ++ E+ IL
Sbjct: 468 KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ 527
Query: 257 RLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISK--EVEEESKQQERGSH 314
R L + +S S+E + + + + +A VE+ + S
Sbjct: 528 RQLEDLVEELSF-------SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
Query: 315 LIQEEEIKVEEEQGDIEVKMSSAEEESEAI 344
+E E+K E E + ++K+ E+E A+
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAV 610
Score = 34.3 bits (77), Expect = 0.42
Identities = 59/331 (17%), Positives = 145/331 (43%), Gaps = 45/331 (13%)
Query: 25 QEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERC 84
Q +EER L ++ +K E +E+ +Q EK +LE +C
Sbjct: 1968 QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV-----------------QC 2010
Query: 85 FPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVV 144
+AEK++ + L + ++ D V ++++ FI L +EK E ++ ++++ +
Sbjct: 2011 --QAEKVRDD---LQKQVKALEID------VEEQVSRFIELEQEKNTELM-DLRQQNQAL 2058
Query: 145 LNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLD 204
+EK++ L E ++++ Q + L+ Q + +F +E ++ LA+
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN-- 2116
Query: 205 SGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGF-EIPRILATSDIAVRLL--HT 261
++++ + L L+++ + R+ + + E+ + L S + +
Sbjct: 2117 --HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRK 2174
Query: 262 HYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAIS---KEVEEESKQQERGSHLIQE 318
H+ V A +S + +D + EK I+ +++E+ ++ E + +Q+
Sbjct: 2175 HFGAVEAKPELS------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2228
Query: 319 EEIKVEEEQGDIEVKMSSAEEESEAIKCERE 349
+++E ++ + ++ E+E++ K + E
Sbjct: 2229 LHMQLEIQKKESTTRLQELEQENKLFKDDME 2259
Score = 32.0 bits (71), Expect = 2.1
Identities = 82/391 (20%), Positives = 158/391 (40%), Gaps = 66/391 (16%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQE-----EEERRLKEEE---------EARLKYEKEEMER 49
K ++ KK+ E LK E EE E E +A L KE+ E+
Sbjct: 2655 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
Query: 50 LEIQRIEKEKWHRLEAKDLERRNEEL----EELYLLERCFPEAEKLKQETKLLSQWKHYI 105
L+ + + KE KDL + + L E+L +LE+ E E QE+K
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEK---EDETEVQESKK-------- 2763
Query: 106 QCDGSPDP-----SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPP 160
C P P S+A + + + + +N+T + +++ + + +NL +
Sbjct: 2764 ACMFEPLPIKLSKSIASQTDGTLKI--SSSNQTPQILVKNAGIQINLQSE---------- 2811
Query: 161 CDLQD--KNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNME-----KVIK 213
C ++ + I Q+ E I ++QEL A EIL ++ +++ ++ E +++K
Sbjct: 2812 CSSEEVTEIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREHYVAVQLLK 2865
Query: 214 DENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVS 273
+E TL ++ S+ ++ I ++ + + H S
Sbjct: 2866 EECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIAS 2925
Query: 274 TPSKEYTSAVTELVKDDVKNVEKAISKEVEE-----ESKQQERGSHLIQE-EEIKVEEEQ 327
E + + T+ +K + +A+ E + ES + H IQ+ E +EE +
Sbjct: 2926 EGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERK 2985
Query: 328 GDIEVKMSSAEEESEAIKCEREMKVLSETVS 358
I +SS ++ ++ +RE +V + S
Sbjct: 2986 AYINT-ISSLKDLITKMQLQREAEVYDSSQS 3015
Score = 30.4 bits (67), Expect = 6.0
Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 6/120 (5%)
Query: 35 EEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQE 94
E L EKE++E E +EKEK LE + L NE+ + +R + E LK
Sbjct: 2617 EMHTSLILEKEQVEIAEKNVLEKEK-KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2675
Query: 95 TKLL---SQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKL 151
T+L + + + + SVA + ++ +KEK + EE++ K + +L + L
Sbjct: 2676 TELFHSNEESGFFNELEALRAESVATKAE--LASYKEKAEKLQEELLVKETNMTSLQKDL 2733
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 47.0 bits (110), Expect = 6e-05
Identities = 77/368 (20%), Positives = 156/368 (42%), Gaps = 52/368 (14%)
Query: 12 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERR 71
+ K+ KAE L++ E+ +E E ++K E+E L+ + E+ K L+
Sbjct: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVK----ELEVLQAKCNEQTKVIDNFTSQLKAT 723
Query: 72 NEELEELYLLERCFPEAE----KLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 127
E+L +L L + E + KL+Q+ + + +++ + + + S A + + +
Sbjct: 724 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 783
Query: 128 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLK-- 185
K E + E S+V L ++L+ + + + + Q S+ + LH K
Sbjct: 784 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEE 840
Query: 186 -FGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFE 244
F + + L K LAD+++ EK ++E + ++ ++ +
Sbjct: 841 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK-----------------AKEKLEND 883
Query: 245 IPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKA--ISKEV 302
I I+ S D+ S L ++ + V EL K E A + K +
Sbjct: 884 IAEIMKMSG----------DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 933
Query: 303 E------EESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSET 356
E E+S+Q+ H +EE+ ++E + D+E KM ++ + + +K E + SET
Sbjct: 934 EDMTVKAEQSQQEAAKKH--EEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSET 990
Query: 357 VSAAQLLL 364
+ + +L
Sbjct: 991 KTKHEEIL 998
Score = 38.1 bits (87), Expect = 0.029
Identities = 72/373 (19%), Positives = 152/373 (40%), Gaps = 57/373 (15%)
Query: 16 TKAERLKLLQEEEERRLKEEEEARLKYEKEEME--RLEIQRIEKEKWHRLEAKDLERRNE 73
T+ E+++L + E L+ ++++ +EME R ++ ++ KEK + LEA + + +
Sbjct: 615 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA--IRSKLD 672
Query: 74 ELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNET 133
+ E+ +L+E + QE ++ + +Q K NE
Sbjct: 673 KAEDQHLVE--MEDTLNKLQEAEIKVKELEVLQA---------------------KCNE- 708
Query: 134 FEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEIL 193
++KV+ N +LK + D K + + + +L++ L A E
Sbjct: 709 ------QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE-----AAEKQ 757
Query: 194 LKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSV--RFSETQIGFEIPRILAT 251
+K + +S + ++ NL++N S E ++ +
Sbjct: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 817
Query: 252 SDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQER 311
S+ AV + + + V+ LH +S ++EK + E+K +E+
Sbjct: 818 SEEAVSVQRSMQETVNKLHQKEEQFNMLSS-----------DLEKLRENLADMEAKFREK 866
Query: 312 GSHLIQEEEIKVEEE-QGDI-EVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSS 369
+E+ IK +E+ + DI E+ S + S+ K E+++ V QL L + ++
Sbjct: 867 DER--EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK-AN 923
Query: 370 EKPDFFEDNVVDL 382
E F + ++ D+
Sbjct: 924 ENASFLQKSIEDM 936
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 47.0 bits (110), Expect = 6e-05
Identities = 77/368 (20%), Positives = 156/368 (42%), Gaps = 52/368 (14%)
Query: 12 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERR 71
+ K+ KAE L++ E+ +E E ++K E+E L+ + E+ K L+
Sbjct: 703 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVK----ELEVLQAKCNEQTKVIDNFTSQLKAT 758
Query: 72 NEELEELYLLERCFPEAE----KLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWK 127
E+L +L L + E + KL+Q+ + + +++ + + + S A + + +
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
Query: 128 EKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLK-- 185
K E + E S+V L ++L+ + + + + Q S+ + LH K
Sbjct: 819 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS---EEAVSVQRSMQETVNKLHQKEE 875
Query: 186 -FGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFE 244
F + + L K LAD+++ EK ++E + ++ ++ +
Sbjct: 876 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK-----------------AKEKLEND 918
Query: 245 IPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKA--ISKEV 302
I I+ S D+ S L ++ + V EL K E A + K +
Sbjct: 919 IAEIMKMSG----------DNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968
Query: 303 E------EESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSET 356
E E+S+Q+ H +EE+ ++E + D+E KM ++ + + +K E + SET
Sbjct: 969 EDMTVKAEQSQQEAAKKH--EEEKKELERKLSDLEKKMETSHNQCQELKARYE-RATSET 1025
Query: 357 VSAAQLLL 364
+ + +L
Sbjct: 1026 KTKHEEIL 1033
Score = 38.1 bits (87), Expect = 0.029
Identities = 72/373 (19%), Positives = 152/373 (40%), Gaps = 57/373 (15%)
Query: 16 TKAERLKLLQEEEERRLKEEEEARLKYEKEEME--RLEIQRIEKEKWHRLEAKDLERRNE 73
T+ E+++L + E L+ ++++ +EME R ++ ++ KEK + LEA + + +
Sbjct: 650 TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA--IRSKLD 707
Query: 74 ELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNET 133
+ E+ +L+E + QE ++ + +Q K NE
Sbjct: 708 KAEDQHLVE--MEDTLNKLQEAEIKVKELEVLQA---------------------KCNE- 743
Query: 134 FEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEIL 193
++KV+ N +LK + D K + + + +L++ L A E
Sbjct: 744 ------QTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE-----AAEKQ 792
Query: 194 LKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSV--RFSETQIGFEIPRILAT 251
+K + +S + ++ NL++N S E ++ +
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 252 SDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQER 311
S+ AV + + + V+ LH +S ++EK + E+K +E+
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEEQFNMLSS-----------DLEKLRENLADMEAKFREK 901
Query: 312 GSHLIQEEEIKVEEE-QGDI-EVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSS 369
+E+ IK +E+ + DI E+ S + S+ K E+++ V QL L + ++
Sbjct: 902 DER--EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK-AN 958
Query: 370 EKPDFFEDNVVDL 382
E F + ++ D+
Sbjct: 959 ENASFLQKSIEDM 971
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 47.0 bits (110), Expect = 6e-05
Identities = 94/423 (22%), Positives = 183/423 (43%), Gaps = 76/423 (17%)
Query: 10 SKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLE 69
S + KV + KL E+ +++ E+E L+ KEE +L++ +E+ K + K E
Sbjct: 301 SAQDKVLREAENKL---EQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK----QGKRAE 353
Query: 70 R-RNEELEELYLLERCFPE--------AEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMN 120
R RNE L L + F + EK++ E ++L ++ C+ + + +
Sbjct: 354 RQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILE--RNLTNCE-KENKRLQERCG 410
Query: 121 TF---ISLWKEKTNETFEE-----------VIEKSKVVLNLIEKLKFIL-LETPPCDLQD 165
+ + + KEK + EE ++ S+V+ L E + IL LE+ +L++
Sbjct: 411 LYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES---ELEN 467
Query: 166 KNIIQYQESILQLQELLHLKFGVATE----ILLKQASTLADLDSGNMEKVIKDENVTLYV 221
K+ I ++ + E LK VA + L +Q + ++ ++EK+I + +
Sbjct: 468 KDEI-LRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKREL 526
Query: 222 WANLKKNPRHRSVRFSETQ---IGFEIPRILATSDIAVRLLHTHYDHVSALHP------- 271
+ +++ FS + IG L S++ ++L + + LH
Sbjct: 527 FGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE-IQKLHANLTANQL 585
Query: 272 --------VSTPSKEYTSAVTELVK-------DDVKNV-EKAISKEVEEESKQQERGSHL 315
S S + +S TE VK + VK+ + ++K+ E+E ++ G
Sbjct: 586 SQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEE 645
Query: 316 IQEEEIKVEEEQGDIEVKMSSAEEESEAI------KCEREMKVLSE-TVSAAQLLLVENS 368
++ + I++E E D++V M+ + + I K K+ SE T +QLL +E
Sbjct: 646 LRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQ 705
Query: 369 SEK 371
E+
Sbjct: 706 LEE 708
Score = 36.6 bits (83), Expect = 0.084
Identities = 90/409 (22%), Positives = 184/409 (44%), Gaps = 69/409 (16%)
Query: 5 AKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLE 64
AK + +++ + K E+++ L+ E E+ L +EK + LE + +++ RLE
Sbjct: 718 AKNAELEQELMEKNEKIRSLETNINT---EHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
Query: 65 AKDLERRNEELEE------------------LYLLERCFPEAE-KLKQETKLLSQWKHYI 105
A+ LE+++++ +E L L+R E++ ++K+E + +
Sbjct: 775 AQ-LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKAL 833
Query: 106 QCDGSPDPSVAQEMNTFISLWKEK----------TNETFEEVI-EKSKVVLNLIEKLKF- 153
Q S + +++++ + + KE+ E FE+ + +KS+ V L ++LK
Sbjct: 834 QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
Query: 154 --ILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLAD----LDSGN 207
L ET ++ ++ +Q Q+ +LQ + + + + L KQ S L +
Sbjct: 894 NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS 953
Query: 208 MEKVIKDEN--VTLYVWANLKKNPRHRSVRFSET--QIGFEIPRIL-ATSDIAVRLLHTH 262
EK+ K E + A+LK R + + + T Q+ E+ + S + ++H
Sbjct: 954 AEKLRKMEEKCESAAHEADLK---RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLK 1010
Query: 263 YD------HVSALHPV----STPSKEYTSAVTELVK----DDVKNVEKAISKEVEEESKQ 308
D H+S L + T ++ T+AV EL K + + E +EV E Q
Sbjct: 1011 RDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQ 1070
Query: 309 QERG---SHLIQEEEIK--VEEEQGDIEVKMSSAEE-ESEAIKCEREMK 351
G S L Q +E++ +++ Q +E K ++ ++ +E +C+ E++
Sbjct: 1071 NAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE 1119
Score = 31.6 bits (70), Expect = 2.7
Identities = 20/78 (25%), Positives = 40/78 (51%)
Query: 19 ERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEEL 78
ER + +E E +KE+E+ KE ++ + R+ +E+ + E R+++++
Sbjct: 1221 ERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQ 1280
Query: 79 YLLERCFPEAEKLKQETK 96
+ER E E +KQ +K
Sbjct: 1281 REIERLSSELEDMKQLSK 1298
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 46.2 bits (108), Expect = 1e-04
Identities = 81/394 (20%), Positives = 152/394 (38%), Gaps = 52/394 (13%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEME-RLEIQRIEKEKWHR 62
+ + S +KK++ E++KL E+ + K+ L KEE LE++R+ +EK
Sbjct: 1918 QVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRL 1977
Query: 63 LEAKDLERRNEELEELYLLERCFPEAE----KLKQETKLLSQWKHYIQCDGSPDPSVAQE 118
+E K+ + E E + E E KL E K+L + + S E
Sbjct: 1978 VEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLE 2037
Query: 119 MNTFISLW---KEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESI 175
++ + K + ++I+K + + KL IL ++ + Q + +
Sbjct: 2038 FTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKM 2097
Query: 176 LQLQELLHLK-----------------FGVATEILLKQASTLADLD---SGNMEKVIKDE 215
+++ L +K F L K LA + M ++I E
Sbjct: 2098 TKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKE 2157
Query: 216 NVTLYVWANLKKNPRHRSVRFS-ETQIGFEIPRILA-------------TSDIAVRLLHT 261
+ L + +H V E + G E ++ D +
Sbjct: 2158 EKMTEEESKLAR--KHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215
Query: 262 HYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI 321
D V S+E+ S E + D+++ E S+E EE +++ER ++EEE
Sbjct: 2216 QVDEVE--------SEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
Query: 322 KVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSE 355
+ +EE+ E ++ EEE + K E++ + + E
Sbjct: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
Score = 40.8 bits (94), Expect = 0.004
Identities = 82/369 (22%), Positives = 152/369 (41%), Gaps = 45/369 (12%)
Query: 6 KKSGSKKKKVTKAERL--KLLQEEEERRLKEEEE----ARLKYEKEEMERLEIQRIEKEK 59
KK+ + K+V R K +EE E+RL +EEE A K EE E ++++ E+
Sbjct: 1461 KKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEE 1520
Query: 60 WHR-----LEAKDLERRNEELEELYLLERCFPEAEKLKQET-------KLLSQWKHYIQC 107
W + L +K E++ ++ EE+ L E E E+ +Q+ + +W +
Sbjct: 1521 WKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRK 1580
Query: 108 DGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKN 167
+ AQE ++ +EK + ++ ++ + + K+ D+
Sbjct: 1581 RARAEKKRAQEERK-LAQEEEKLAQEERQLAQEERKLAQAYVKIT----------QDDRE 1629
Query: 168 IIQYQESILQLQELLHL---KFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWAN 224
+ Q + Q +E L K E L ++ LA EKV ++E
Sbjct: 1630 MAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAK----KWEKVAREEEKLA----- 1680
Query: 225 LKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVS-ALHPVSTPSKEYTSAV 283
KK + V+ Q E+P+ D + L + + + +S +E
Sbjct: 1681 -KKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEE 1739
Query: 284 TELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEA 343
+LV++ K E+ + + E K E + L QEEE+ ++E++ + K EEE E
Sbjct: 1740 GKLVEEKKKLAEEEEALAWQRE-KLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE-ER 1797
Query: 344 IKCEREMKV 352
+ +RE +
Sbjct: 1798 LGRKREQLI 1806
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/77 (36%), Positives = 47/77 (61%), Gaps = 11/77 (14%)
Query: 25 QEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERC 84
+E EE ++EEEE R E+EE E ++++ E+EK + K E++ EE++E E
Sbjct: 2255 EEREEEEVREEEEERK--EEEEGEEKQVEKEEEEK----KKKKKEKKKEEVQE---KEEV 2305
Query: 85 FPEAEKL--KQETKLLS 99
F E E++ ++ET+ LS
Sbjct: 2306 FEEKEEIMSEEETESLS 2322
Score = 35.8 bits (81), Expect = 0.14
Identities = 57/245 (23%), Positives = 109/245 (44%), Gaps = 46/245 (18%)
Query: 10 SKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEM----------ERLEIQRIEKEK 59
S K++ E KL+ EE+++L EEEEA L +++E++ E L IQ EK
Sbjct: 1729 SWKEEELNQEEGKLV--EEKKKLAEEEEA-LAWQREKLSEEETKLAQEEELLIQEKEKLA 1785
Query: 60 WHR----LEAKDLERRNEELEELYL-----LERCFPEAEKLKQETKLLSQWKHYIQCDGS 110
H+ E + L R+ E+L E + ER E+L + +L Q K+ Q
Sbjct: 1786 QHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQ---- 1841
Query: 111 PDPSVAQEMNTF------ISLWKEKTNETFEEVIEK-------SKVVLNLIEKL----KF 153
++AQE + KE+ + +++++ +K++ + EKL +
Sbjct: 1842 EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKET 1901
Query: 154 ILLETPPCDLQDKNIIQYQESILQLQELL---HLKFGVATEILLKQASTLADLDSGNMEK 210
++ + +K ++Q ++S+ + QE L +K + ++ + +LD EK
Sbjct: 1902 VIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEK 1961
Query: 211 VIKDE 215
+ E
Sbjct: 1962 ALNLE 1966
Score = 35.8 bits (81), Expect = 0.14
Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 11 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIE------KEKWHRLE 64
++++V + E + +EE E + E+EE K +K+E ++ E+Q E +E E
Sbjct: 2258 EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE 2317
Query: 65 AKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQ 100
+ L EE E L E E E LK+E + Q
Sbjct: 2318 TESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQ 2353
Score = 34.7 bits (78), Expect = 0.32
Identities = 84/386 (21%), Positives = 162/386 (41%), Gaps = 59/386 (15%)
Query: 10 SKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERL-EIQRIEKEKWHR---LEA 65
+K++K E +L EE+ RL E +E K E E R ++ ++E+E + R LE
Sbjct: 1957 AKEEKALNLEMKRLA--EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEE 2014
Query: 66 KDL--ERRNEELEELYLL---------ERCFPEAE-KLKQETKLLSQWKHYIQCDGSPDP 113
K L E R +EE + +R F + + KL + ++ L + + + S +P
Sbjct: 2015 KILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESL----SKEP 2070
Query: 114 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQE 173
+ ++ + + +E I+ +K+ L K + + +E D+++ + + +
Sbjct: 2071 AKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRS 2130
Query: 174 SILQLQELLHLKFGVAT----------EILLKQASTLADLDS-----GNMEKVIKDENVT 218
+ + ++ L K E + ++ S LA S E I++E V
Sbjct: 2131 ELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVI 2190
Query: 219 LYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKE 278
+ LK+ R R E + G + P+ +S + H+ +E
Sbjct: 2191 PF----LKRRWRKRK----EAKRG-DKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQE 2241
Query: 279 YTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAE 338
S+ E +++ + E+ +E EEE K++E G +E++++ EEE+ + K E
Sbjct: 2242 SLSSEEEEEREEEEEREEEEVREEEEERKEEEEG----EEKQVEKEEEEKKKKKKEKKKE 2297
Query: 339 ---------EESEAIKCEREMKVLSE 355
EE E I E E + LS+
Sbjct: 2298 EVQEKEEVFEEKEEIMSEEETESLSD 2323
Score = 33.5 bits (75), Expect = 0.71
Identities = 24/69 (34%), Positives = 40/69 (57%), Gaps = 5/69 (7%)
Query: 288 KDDVKNVEKAISKEVEEESKQQ-ERGSHLIQEEEIKVEEEQGDI---EVKMSSAEEESEA 343
K++ + EK + KE EE+ K++ E+ +QE+E +V EE+ +I E S ++EE E
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKE-EVFEEKEEIMSEEETESLSDEEEEE 2328
Query: 344 IKCEREMKV 352
C E +V
Sbjct: 2329 ESCSLEEEV 2337
Score = 33.1 bits (74), Expect = 0.93
Identities = 22/79 (27%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEI-QRIEKEKWHRLE 64
KK K+KK + + + + EE+E + EEE L E+EE E + + +++EK +
Sbjct: 2287 KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKK 2346
Query: 65 AKDLERRNEELEELYLLER 83
K + + + + L ER
Sbjct: 2347 EKQFKLQEQRRKSLRGRER 2365
Score = 32.7 bits (73), Expect = 1.2
Identities = 41/200 (20%), Positives = 86/200 (43%), Gaps = 20/200 (10%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEE-------------RRLKEEEEARLKYEKEEMERL 50
K +K ++ K+ + +L +EEE RR ++ +EA+ + +E
Sbjct: 2156 KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS 2215
Query: 51 EIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGS 110
++ +E E+ E + L E+ E L E E E+ ++E ++ + + + +
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275
Query: 111 PDPSVAQEMNTFISLWKEKTNETF---EEVIEKSKVVLN--LIEKLKFILLETPPCDLQD 165
+ V +E KEK E EEV E+ + +++ E L E C L++
Sbjct: 2276 EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEE 2335
Query: 166 KNIIQYQESILQLQELLHLK 185
+ + ++ IL+ ++ L+
Sbjct: 2336 E--VDREKEILKKEKQFKLQ 2353
Score = 32.0 bits (71), Expect = 2.1
Identities = 44/183 (24%), Positives = 80/183 (43%), Gaps = 26/183 (14%)
Query: 3 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 62
P+ +++ ++K E +L + EE KE EE+ + E + +E++K
Sbjct: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKE----------EELNQEEGKLVEEKKKLA 1750
Query: 63 LEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTF 122
E + L + E+L E E KL QE +LL Q K + P + +
Sbjct: 1751 EEEEALAWQREKLSE---------EETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGR- 1800
Query: 123 ISLWKEKTNETFEEVIEKSKVVLNLIEKL---KFILLETPPCDLQDKNIIQYQESILQLQ 179
+E+ E ++ +K + +N +E+L K IL + + KN+ Q +E + Q +
Sbjct: 1801 ---KREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRK 1857
Query: 180 ELL 182
E L
Sbjct: 1858 ENL 1860
Score = 30.8 bits (68), Expect = 4.6
Identities = 35/157 (22%), Positives = 72/157 (45%), Gaps = 33/157 (21%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEE---EEARL-----------------KYE 43
K +K G K+++TK ER + EE L+E+ +E +L +++
Sbjct: 1409 KERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
Query: 44 KEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKH 103
+ E + + KE+W + ++ E+ ++ E+L PE E L+++ KL +W+
Sbjct: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKL------SPEEEMLQEDKKL--KWEE 1520
Query: 104 YIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEK 140
+ Q + S ++E +K++ T EE + +
Sbjct: 1521 WKQVWENMLSSKSKEQQ-----YKDEEEVTLEEEVSR 1552
Score = 30.4 bits (67), Expect = 6.0
Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 4/77 (5%)
Query: 295 EKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLS 354
EK +++E+EE E S +EEE+ +E+G + + EE EA+ +RE
Sbjct: 1711 EKELAQELEELEWDMEELSW--KEEELN--QEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
Query: 355 ETVSAAQLLLVENSSEK 371
ET A + L+ EK
Sbjct: 1767 ETKLAQEEELLIQEKEK 1783
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 268 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 322
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 72 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 130
Query: 323 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 378
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
Query: 379 V 379
V
Sbjct: 191 V 191
Score = 34.7 bits (78), Expect = 0.32
Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 22/133 (16%)
Query: 3 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 62
P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++ EK
Sbjct: 789 PVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLLEKKLD 847
Query: 63 LEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETKLLSQW 101
AKD + R E+ LEE L E+ F EAEK + + +L SQ
Sbjct: 848 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQS 907
Query: 102 KHYIQCDGSPDPS 114
K I+ P PS
Sbjct: 908 KRTIEGLRGPPPS 920
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 268 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 322
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 186 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 244
Query: 323 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 378
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 245 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 304
Query: 379 V 379
V
Sbjct: 305 V 305
Score = 34.7 bits (78), Expect = 0.32
Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 22/133 (16%)
Query: 3 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 62
P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++ EK
Sbjct: 903 PVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLLEKKLD 961
Query: 63 LEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETKLLSQW 101
AKD + R E+ LEE L E+ F EAEK + + +L SQ
Sbjct: 962 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQS 1021
Query: 102 KHYIQCDGSPDPS 114
K I+ P PS
Sbjct: 1022 KRTIEGLRGPPPS 1034
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 268 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 322
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 72 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 130
Query: 323 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 378
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
Query: 379 V 379
V
Sbjct: 191 V 191
Score = 34.7 bits (78), Expect = 0.32
Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 22/133 (16%)
Query: 3 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 62
P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++ EK
Sbjct: 789 PVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLLEKKLD 847
Query: 63 LEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETKLLSQW 101
AKD + R E+ LEE L E+ F EAEK + + +L SQ
Sbjct: 848 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQS 907
Query: 102 KHYIQCDGSPDPS 114
K I+ P PS
Sbjct: 908 KRTIEGLRGPPPS 920
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/121 (27%), Positives = 68/121 (56%), Gaps = 10/121 (8%)
Query: 268 ALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEI-----K 322
A+ P+ +PSKE + V+D + +E K E+++K +E H IQ E++ K
Sbjct: 206 AVPPLPSPSKE-EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSK 264
Query: 323 VEEEQGDIEVKMSSAEEES-EAIKC-EREMKVLSETVSAAQLLLV--ENSSEKPDFFEDN 378
++E+Q D++ ++ A +E+ EA++ ER M+ +++T A ++ + E + E+ + +
Sbjct: 265 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 324
Query: 379 V 379
V
Sbjct: 325 V 325
Score = 34.7 bits (78), Expect = 0.32
Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 22/133 (16%)
Query: 3 PKAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHR 62
P ++ + + ++T AE L L E+ E +KE +++ LK + EE+ ++ EK
Sbjct: 923 PVELRAAALRAEITDAEGLGLKLEDRETVIKELKKS-LKIKGEELSEANVRLSLLEKKLD 981
Query: 63 LEAKDLERRNEE----LEELYLL----ERCFP-------------EAEKLKQETKLLSQW 101
AKD + R E+ LEE L E+ F EAEK + + +L SQ
Sbjct: 982 SAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQS 1041
Query: 102 KHYIQCDGSPDPS 114
K I+ P PS
Sbjct: 1042 KRTIEGLRGPPPS 1054
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 46.2 bits (108), Expect = 1e-04
Identities = 79/366 (21%), Positives = 144/366 (39%), Gaps = 52/366 (14%)
Query: 11 KKKKVTKAERLKLLQEE-----------EERRLKEEEEARLKYE------KEEMERLEIQ 53
KK++ +AERL+ +QEE E+RR KEEEE R+K E +EE ER + +
Sbjct: 916 KKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKRE 975
Query: 54 RIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDP 113
EK +EA+ ++ EE ++ +LE+ E + ++ I + D
Sbjct: 976 DDEKRIQAEVEAQLARQKEEESQQQAVLEQ---ERRDRELALRIAQSEAELISDEAQADL 1032
Query: 114 SVAQEMNTFISLWKEKTNETFEEVIEKSKVVL---NLIEKLKFILLETPPCDLQDK-NII 169
++ + T + E+ + E + + VL K+ L + +L+D N
Sbjct: 1033 ALRRNDGTRPKMTPEQMAKEMSEFLSRGPAVLATKAAAGTKKYDLSKWKYAELRDTINTS 1092
Query: 170 QYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNP 229
E + +E H + V K + + K + D + ++ + ++NP
Sbjct: 1093 CDIELLAACREEFHRRLKVYHAWKSKNKKRNTETEQ-RAPKSVTDYDFAPFLNNSPQQNP 1151
Query: 230 ------RHRSVRFSETQIGFEIPRILATSDI------AVRLLHTHYD-----HVSALHPV 272
R R + + Q F IP I + H+D LHP
Sbjct: 1152 AAQIPARQREIEMNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQMELHPD 1211
Query: 273 STPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEV 332
P + KDD++ E +EE ++RG+ ++ + ++ E G I+
Sbjct: 1212 KPP------ILLVAGKDDMEMCE----LNLEETGLTRKRGAEILPRQFEEIWERCGGIQY 1261
Query: 333 KMSSAE 338
++ E
Sbjct: 1262 LQNAIE 1267
Score = 36.6 bits (83), Expect = 0.084
Identities = 32/123 (26%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 4 KAKKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRL 63
K ++ +++++ K QEEEER+ +E++E R++ E E ++ R ++E+ +
Sbjct: 945 KRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAEVE----AQLARQKEEESQQQ 1000
Query: 64 EAKDLERRNEELEELYLLERCFPEAEKLKQETK--LLSQWKHYIQCDGSPDPSVAQEMNT 121
+ ERR+ EL L EAE + E + L + + +P+ +A+EM+
Sbjct: 1001 AVLEQERRDREL----ALRIAQSEAELISDEAQADLALRRNDGTRPKMTPE-QMAKEMSE 1055
Query: 122 FIS 124
F+S
Sbjct: 1056 FLS 1058
Score = 33.5 bits (75), Expect = 0.71
Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 5/73 (6%)
Query: 22 KLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLL 81
+LL ++++ +EEE RL+ +EEME+ +R E EK R K+ E R +LE
Sbjct: 908 ELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRR---KEEEERRMKLE--MEA 962
Query: 82 ERCFPEAEKLKQE 94
+R E E+ K+E
Sbjct: 963 KRKQEEEERKKRE 975
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 46.2 bits (108), Expect = 1e-04
Identities = 90/436 (20%), Positives = 176/436 (40%), Gaps = 62/436 (14%)
Query: 6 KKSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEME-RLEIQRIEKEKWH-RL 63
+K K+ V K + + L EE++ R+KE EE L E + + E++ +KE H L
Sbjct: 1554 QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 64 EAKDLERRNEELEELYLLERCFPEAE-KLKQETK-------LLSQWKHYIQCDGSPDPSV 115
K E + LE+ E AE K K E K LLSQ + + S
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH 1673
Query: 116 AQEMNTFISLWKEKTN---ETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQ-- 170
E+NT + + + + E + V L + K + T + + +Q
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 171 YQESILQLQ------ELLHLKFGVATE-----------------ILLKQASTLADLDS-- 205
Y+E I LQ E L + G E I L+ A D
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSM 1793
Query: 206 -GNMEKVIKDEN--VTLYVWANLKKNPRHRSVRFSET--QIGFEIPRILATSDIAVRLLH 260
G++++ ++++N +L V +++K +++ + + ++ + L ++ ++L
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853
Query: 261 THYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVE-------KAISKEVEEESKQQERGS 313
+ L KE E + + ++ + E+ EE+ +++ S
Sbjct: 1854 ---QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 314 HLIQEEEIK-VEEEQGDIEVKMSSAEEE-----SEAIKCEREMKVL-SETVSAAQLLLVE 366
HL+Q + + +E + D+E K++ AE E E ++ ++++++L E ++L E
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE 1970
Query: 367 NSSEKPDFFEDNVVDL 382
E+ + + DL
Sbjct: 1971 YDQEREEKIKQEQEDL 1986
Score = 45.1 bits (105), Expect = 2e-04
Identities = 77/361 (21%), Positives = 159/361 (44%), Gaps = 67/361 (18%)
Query: 11 KKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEM-----ERLEIQRIEKEKWHRLEA 65
K++ T+ E+L+ E+E+ L +++E + EEM E+L++++ E E +
Sbjct: 635 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELS 694
Query: 66 KDLERRNEELEELYLLERCFPEAEKLKQE--TKLLSQWKHYIQCDGSPDPSVAQEMNTFI 123
+ L+ R++ EEL +L+ + +K+KQE K+ Q H+ Q++++ I
Sbjct: 695 EVLKARHKLEEELSVLK---DQTDKMKQELEAKMDEQKNHH-----------QQQVDSII 740
Query: 124 SLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLH 183
+ T K + + I +L+ +L E +DK++ ++Q + L+ +
Sbjct: 741 KEHEVSIQRT-------EKALKDQINQLELLLKE------RDKHLKEHQAHVENLEADIK 787
Query: 184 LKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGF 243
G L+QAS A LD + E Y + + + +
Sbjct: 788 RSEGE-----LQQAS--AKLDVFQSYQSATHEQTKAY---------EEQLAQLQQKLLDL 831
Query: 244 EIPRILATSDIAV-----RLLHTHYD-HVSALHPVSTPSKEYTSAVTELVKDDVKNVEKA 297
E RIL T +A + + T D H + + ++ S + + VK++ +
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ----KVKSLTQV 887
Query: 298 ISKEVEEESKQQERGSHLIQEEEIKV----EEEQGDIEV---KMSSAEEESEAIKCEREM 350
++E+ +K+QE+ ++ E+E + E ++ +IE+ K+S+ E+ + E E
Sbjct: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET 947
Query: 351 K 351
K
Sbjct: 948 K 948
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/367 (19%), Positives = 151/367 (41%), Gaps = 62/367 (16%)
Query: 12 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERR 71
+K K + + +L EE E + K +E+ K EK + + E+Q K+K EAK +
Sbjct: 929 QKLSAKEDSIHILNEEYETKFKNQEK---KMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 72 NEELEELYLLERCFPEAEKLKQE-----------TKLLSQWKHYIQCDGSPDPSVAQEMN 120
EL E+ F A+ L+ ++L + K I+ S +E+N
Sbjct: 986 ENTALELSQKEKQF-NAKMLEMAQANSAGISDAVSRLETNQKEQIE---SLTEVHRRELN 1041
Query: 121 TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQE 180
IS+W++K N+ EE LQ+ + IQ QE ++ E
Sbjct: 1042 DVISIWEKKLNQQAEE--------------------------LQEIHEIQLQEKEQEVAE 1075
Query: 181 LLH--LKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRH-RSVRFS 237
L L FG E + K+ + L E+ +K + + LK+ H S+
Sbjct: 1076 LKQKILLFGCEKEEMNKEITWL-------KEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 238 ETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKA 297
ET++ + ++ + +++ + + L ++ K S +T + K
Sbjct: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKL--------KT 1180
Query: 298 ISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETV 357
+E + E+ + ++++ ++ ++ ++ +++ +++EA+ + ++++ +
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1240
Query: 358 SAAQLLL 364
S +L
Sbjct: 1241 SKTNAIL 1247
Score = 39.3 bits (90), Expect = 0.013
Identities = 73/375 (19%), Positives = 141/375 (37%), Gaps = 97/375 (25%)
Query: 11 KKKKVTKAERLKLLQEEEERRLKEE-------------EEARLKYEKEEMERLEIQRIEK 57
KK + +L+ L E+E R ++E E+ ++ EK + E L+I + EK
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ-EK 529
Query: 58 EKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQ 117
E+ L ++L EL++ +L + L+QE + + ++ + S + S+ +
Sbjct: 530 EQQESLALEEL-----ELQKKAILTESENKLRDLQQEAE--TYRTRILELESSLEKSLQE 582
Query: 118 EMN------TFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQY 171
N + K K N+ ++EK K L E LK +
Sbjct: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL---ESLK------------------H 621
Query: 172 QESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRH 231
Q+ L ++L LK TE+ L + E ++KD+ +
Sbjct: 622 QQDALWTEKLQVLKQQYQTEM-----EKLREKCEQEKETLLKDKEIIFQA---------- 666
Query: 232 RSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDV 291
H+ ++ + + E + ++
Sbjct: 667 ---------------------------------HIEEMNEKTLEKLDVKQTELESLSSEL 693
Query: 292 KNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMK 351
V KA K EE S +++ + QE E K++E++ + ++ S +E E + +R K
Sbjct: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE-VSIQRTEK 752
Query: 352 VLSETVSAAQLLLVE 366
L + ++ +LLL E
Sbjct: 753 ALKDQINQLELLLKE 767
Score = 38.1 bits (87), Expect = 0.029
Identities = 63/332 (18%), Positives = 149/332 (44%), Gaps = 29/332 (8%)
Query: 12 KKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERR 71
K + + L+ + ++ ++ L +E+E + +++++ L+ + +++ HR+E ++L +
Sbjct: 1822 KNNIQAKQNLENVFDDVQKTL-QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880
Query: 72 NEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTN 131
E+L+ L ++ E L++ T+ S+ H +Q P + M + + K
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKSK-SHLVQ------PKLLSNMEAQHNDLEFKLA 1933
Query: 132 ETFEEVIEKSKVVLNLIEKLKFILLE-TPPCDLQDKNIIQ-YQESILQLQELLHLKFGVA 189
E + K ++ L + L+ + E ++ K Q +E I Q QE L LK
Sbjct: 1934 GAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNST 1993
Query: 190 TEILLKQASTLADLDSGNMEKVIKDE-NVTLYVWANLKKNPRHRSVRFSETQIGFEIPRI 248
+ L+++ +T +E IK+ N V A L ++ + ET ++ +
Sbjct: 1994 LKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ------EETN---QLLKK 2044
Query: 249 LATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQ 308
+A D ++ Y+ + + +E T+ V +L + ++ ++K +++E+E
Sbjct: 2045 IAEKDDDLKRTAKRYEEI-----LDAREEEMTAKVRDL-QTQLEELQKKYQQKLEQE--- 2095
Query: 309 QERGSHLIQEEEIKVEEEQGDIEVKMSSAEEE 340
+ G+ + E++ + Q + S +E+
Sbjct: 2096 ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQ 2127
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,346,000
Number of Sequences: 37866
Number of extensions: 1296081
Number of successful extensions: 21100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 246
Number of HSP's successfully gapped in prelim test: 629
Number of HSP's that attempted gapping in prelim test: 10178
Number of HSP's gapped (non-prelim): 7072
length of query: 722
length of database: 18,247,518
effective HSP length: 110
effective length of query: 612
effective length of database: 14,082,258
effective search space: 8618341896
effective search space used: 8618341896
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.