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Search of human proteins with 4557793
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557793 neurofibromin isoform 2 [Homo sapiens]
(2818 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 5613 0.0
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 5600 0.0
gi|189458804 neurofibromin isoform 3 [Homo sapiens] 1155 0.0
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 115 6e-25
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 115 6e-25
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 112 4e-24
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 112 4e-24
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 108 7e-23
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 108 7e-23
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 107 1e-22
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 100 2e-20
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 95 9e-19
gi|130502162 RAS protein activator like 3 [Homo sapiens] 88 1e-16
gi|4759026 RAS protein activator like 1 [Homo sapiens] 86 5e-16
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 79 5e-14
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 79 5e-14
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 77 2e-13
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 77 2e-13
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 77 2e-13
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 77 2e-13
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 76 4e-13
gi|4506787 IQ motif containing GTPase activating protein 1 [Homo... 75 7e-13
gi|39753961 IQ motif containing GTPase activating protein 3 [Hom... 68 1e-10
gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo s... 47 3e-04
gi|207450721 ganglioside induced differentiation associated prot... 40 0.025
gi|8923143 ganglioside induced differentiation associated protei... 39 0.056
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 34 2.3
gi|117606355 furry homolog [Homo sapiens] 33 3.0
gi|119874201 furry-like [Homo sapiens] 33 4.0
gi|66529407 tensin [Homo sapiens] 33 4.0
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 5613 bits (14560), Expect = 0.0
Identities = 2818/2818 (100%), Positives = 2818/2818 (100%)
Query: 1 MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT 60
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
Sbjct: 1 MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT 60
Query: 61 ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF 120
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
Sbjct: 61 ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF 120
Query: 121 LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL 180
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
Sbjct: 121 LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL 180
Query: 181 QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT 240
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
Sbjct: 181 QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT 240
Query: 241 DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL 300
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
Sbjct: 241 DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL 300
Query: 301 DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP 360
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
Sbjct: 301 DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP 360
Query: 361 SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN 420
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
Sbjct: 361 SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN 420
Query: 421 SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK 480
SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK
Sbjct: 421 SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK 480
Query: 481 PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE 540
PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
Sbjct: 481 PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE 540
Query: 541 IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL 600
IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL
Sbjct: 541 IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL 600
Query: 601 REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK 660
REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK
Sbjct: 601 REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK 660
Query: 661 GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR 720
GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR
Sbjct: 661 GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR 720
Query: 721 CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT 780
CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT
Sbjct: 721 CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT 780
Query: 781 HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM 840
HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM
Sbjct: 781 HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM 840
Query: 841 TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS 900
TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS
Sbjct: 841 TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS 900
Query: 901 LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF 960
LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF
Sbjct: 901 LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF 960
Query: 961 VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE 1020
VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE
Sbjct: 961 VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE 1020
Query: 1021 VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL 1080
VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL
Sbjct: 1021 VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL 1080
Query: 1081 AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS 1140
AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS
Sbjct: 1081 AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS 1140
Query: 1141 LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV 1200
LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV
Sbjct: 1141 LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV 1200
Query: 1201 LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM 1260
LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM
Sbjct: 1201 LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM 1260
Query: 1261 FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE
Sbjct: 1261 FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
Query: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS 1380
VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS
Sbjct: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS 1380
Query: 1381 IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHM 1440
IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHM
Sbjct: 1381 IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEEHM 1440
Query: 1441 RPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQY 1500
RPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQY
Sbjct: 1441 RPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQY 1500
Query: 1501 LSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEK 1560
LSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEK
Sbjct: 1501 LSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVHEK 1560
Query: 1561 EEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEI 1620
EEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEI
Sbjct: 1561 EEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEI 1620
Query: 1621 VVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLK 1680
VVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLK
Sbjct: 1621 VVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTGLK 1680
Query: 1681 GSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTA 1740
GSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTA
Sbjct: 1681 GSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTA 1740
Query: 1741 VQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIV 1800
VQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIV
Sbjct: 1741 VQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIV 1800
Query: 1801 QSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALT 1860
QSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALT
Sbjct: 1801 QSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALT 1860
Query: 1861 CTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIEL 1920
CTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIEL
Sbjct: 1861 CTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIEL 1920
Query: 1921 KHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLG 1980
KHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLG
Sbjct: 1921 KHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLG 1980
Query: 1981 QITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKT 2040
QITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKT
Sbjct: 1981 QITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKT 2040
Query: 2041 CLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRAS 2100
CLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRAS
Sbjct: 2041 CLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRAS 2100
Query: 2101 THGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSS 2160
THGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSS
Sbjct: 2101 THGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSS 2160
Query: 2161 YRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYN 2220
YRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYN
Sbjct: 2161 YRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYN 2220
Query: 2221 PSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKL 2280
PSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKL
Sbjct: 2221 PSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKL 2280
Query: 2281 QPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFM 2340
QPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFM
Sbjct: 2281 QPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFM 2340
Query: 2341 AIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVN 2400
AIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVN
Sbjct: 2341 AIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVN 2400
Query: 2401 KHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHG 2460
KHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHG
Sbjct: 2401 KHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHG 2460
Query: 2461 DPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTR 2520
DPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTR
Sbjct: 2461 DPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTR 2520
Query: 2521 KSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSES 2580
KSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSES
Sbjct: 2521 KSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSES 2580
Query: 2581 NVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLL 2640
NVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLL
Sbjct: 2581 NVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLL 2640
Query: 2641 DSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQ 2700
DSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQ
Sbjct: 2641 DSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQ 2700
Query: 2701 TQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNS 2760
TQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNS
Sbjct: 2701 TQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNS 2760
Query: 2761 MTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV 2818
MTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV
Sbjct: 2761 MTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV 2818
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 5600 bits (14528), Expect = 0.0
Identities = 2818/2839 (99%), Positives = 2818/2839 (99%), Gaps = 21/2839 (0%)
Query: 1 MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT 60
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
Sbjct: 1 MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT 60
Query: 61 ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF 120
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
Sbjct: 61 ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF 120
Query: 121 LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL 180
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
Sbjct: 121 LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL 180
Query: 181 QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT 240
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
Sbjct: 181 QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT 240
Query: 241 DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL 300
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
Sbjct: 241 DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL 300
Query: 301 DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP 360
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
Sbjct: 301 DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP 360
Query: 361 SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN 420
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
Sbjct: 361 SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN 420
Query: 421 SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK 480
SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK
Sbjct: 421 SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK 480
Query: 481 PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE 540
PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
Sbjct: 481 PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE 540
Query: 541 IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL 600
IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL
Sbjct: 541 IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL 600
Query: 601 REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK 660
REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK
Sbjct: 601 REILICRNKFLLKNKQADRSSCHFLLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRK 660
Query: 661 GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR 720
GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR
Sbjct: 661 GKGNSSMDSAAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIR 720
Query: 721 CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT 780
CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT
Sbjct: 721 CGVDEVSVHNLLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDT 780
Query: 781 HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM 840
HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM
Sbjct: 781 HAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINM 840
Query: 841 TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS 900
TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS
Sbjct: 841 TGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLS 900
Query: 901 LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF 960
LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF
Sbjct: 901 LMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQF 960
Query: 961 VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE 1020
VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE
Sbjct: 961 VEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVE 1020
Query: 1021 VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL 1080
VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL
Sbjct: 1021 VMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLL 1080
Query: 1081 AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS 1140
AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS
Sbjct: 1081 AGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLAS 1140
Query: 1141 LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV 1200
LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV
Sbjct: 1141 LRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETV 1200
Query: 1201 LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM 1260
LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM
Sbjct: 1201 LADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNM 1260
Query: 1261 FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE
Sbjct: 1261 FSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
Query: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQ---------- 1370
VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQ
Sbjct: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKA 1380
Query: 1371 -----------VVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLK 1419
VVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLK
Sbjct: 1381 TVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLK 1440
Query: 1420 LMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFIS 1479
LMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFIS
Sbjct: 1441 LMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFIS 1500
Query: 1480 DGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWS 1539
DGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWS
Sbjct: 1501 DGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWS 1560
Query: 1540 SLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQING 1599
SLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQING
Sbjct: 1561 SLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQING 1620
Query: 1600 DLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIY 1659
DLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIY
Sbjct: 1621 DLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIY 1680
Query: 1660 NCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVF 1719
NCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVF
Sbjct: 1681 NCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVF 1740
Query: 1720 HNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFT 1779
HNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFT
Sbjct: 1741 HNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFT 1800
Query: 1780 LTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALL 1839
LTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALL
Sbjct: 1801 LTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALL 1860
Query: 1840 NLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEP 1899
NLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEP
Sbjct: 1861 NLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEP 1920
Query: 1900 HLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLIT 1959
HLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLIT
Sbjct: 1921 HLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLIT 1980
Query: 1960 MTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALAS 2019
MTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALAS
Sbjct: 1981 MTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALAS 2040
Query: 2020 GNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHL 2079
GNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHL
Sbjct: 2041 GNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHL 2100
Query: 2080 PYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPK 2139
PYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPK
Sbjct: 2101 PYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPK 2160
Query: 2140 FYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDI 2199
FYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDI
Sbjct: 2161 FYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDI 2220
Query: 2200 PTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLK 2259
PTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLK
Sbjct: 2221 PTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLK 2280
Query: 2260 GPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQ 2319
GPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQ
Sbjct: 2281 GPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQ 2340
Query: 2320 NLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRH 2379
NLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRH
Sbjct: 2341 NLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRH 2400
Query: 2380 PSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKS 2439
PSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKS
Sbjct: 2401 PSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKS 2460
Query: 2440 LLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARK 2499
LLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARK
Sbjct: 2461 LLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARK 2520
Query: 2500 SMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEME 2559
SMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEME
Sbjct: 2521 SMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEME 2580
Query: 2560 TQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILY 2619
TQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILY
Sbjct: 2581 TQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILY 2640
Query: 2620 EYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQT 2679
EYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQT
Sbjct: 2641 EYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQT 2700
Query: 2680 SYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTS 2739
SYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTS
Sbjct: 2701 SYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTS 2760
Query: 2740 PYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQ 2799
PYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQ
Sbjct: 2761 PYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQ 2820
Query: 2800 VQKQRSAGSFKRNSIKKIV 2818
VQKQRSAGSFKRNSIKKIV
Sbjct: 2821 VQKQRSAGSFKRNSIKKIV 2839
>gi|189458804 neurofibromin isoform 3 [Homo sapiens]
Length = 593
Score = 1155 bits (2987), Expect = 0.0
Identities = 573/581 (98%), Positives = 576/581 (99%)
Query: 1 MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT 60
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
Sbjct: 1 MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT 60
Query: 61 ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF 120
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
Sbjct: 61 ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF 120
Query: 121 LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL 180
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
Sbjct: 121 LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL 180
Query: 181 QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT 240
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
Sbjct: 181 QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT 240
Query: 241 DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL 300
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
Sbjct: 241 DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL 300
Query: 301 DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP 360
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
Sbjct: 301 DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP 360
Query: 361 SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN 420
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
Sbjct: 361 SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN 420
Query: 421 SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK 480
SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK
Sbjct: 421 SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK 480
Query: 481 PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE 540
PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
Sbjct: 481 PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE 540
Query: 541 IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYI 581
IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEI +++
Sbjct: 541 IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEIRYMYFYFL 581
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 115 bits (288), Expect = 6e-25
Identities = 89/287 (31%), Positives = 146/287 (50%), Gaps = 10/287 (3%)
Query: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNS 1279
L + AL ++ +E+A LV + S + L ++ EV+ D+ +FR N+
Sbjct: 233 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENT 292
Query: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
LA+K + K+ G YLQ L ++ + S + + EVDP++ ++ L E+Q NL
Sbjct: 293 LATKAIEEYLKLVGQKYLQDALGEFIKALYESDE----NCEVDPSKCSAAD-LPEHQGNL 347
Query: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRF-PQNSIGAVGSAMFLRFINPAIV 1398
E F II+S FP +L+ V Q S R P S + +++FLRF+ PAI+
Sbjct: 348 KMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIM 407
Query: 1399 SPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRF 1457
SP +L + P R R L L++K+ Q++AN F +KEE+M N F++ + +RF
Sbjct: 408 SPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRF 467
Query: 1458 FLDIASDCPTSDAVNHSLSFISDGNVL-ALHRLLWNNQEKIGQYLSS 1503
L+I++ S+ +I G L +LH LLW ++ Q + S
Sbjct: 468 LLEISNPETLSNTAGFE-GYIDLGRELSSLHSLLWEAVSQLEQSIVS 513
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 115 bits (288), Expect = 6e-25
Identities = 89/287 (31%), Positives = 146/287 (50%), Gaps = 10/287 (3%)
Query: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNS 1279
L + AL ++ +E+A LV + S + L ++ EV+ D+ +FR N+
Sbjct: 329 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENT 388
Query: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
LA+K + K+ G YLQ L ++ + S + + EVDP++ ++ L E+Q NL
Sbjct: 389 LATKAIEEYLKLVGQKYLQDALGEFIKALYESDE----NCEVDPSKCSAAD-LPEHQGNL 443
Query: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRF-PQNSIGAVGSAMFLRFINPAIV 1398
E F II+S FP +L+ V Q S R P S + +++FLRF+ PAI+
Sbjct: 444 KMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIM 503
Query: 1399 SPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRF 1457
SP +L + P R R L L++K+ Q++AN F +KEE+M N F++ + +RF
Sbjct: 504 SPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRF 563
Query: 1458 FLDIASDCPTSDAVNHSLSFISDGNVL-ALHRLLWNNQEKIGQYLSS 1503
L+I++ S+ +I G L +LH LLW ++ Q + S
Sbjct: 564 LLEISNPETLSNTAGFE-GYIDLGRELSSLHSLLWEAVSQLEQSIVS 609
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 112 bits (281), Expect = 4e-24
Identities = 90/294 (30%), Positives = 147/294 (50%), Gaps = 15/294 (5%)
Query: 1218 QGELPIAMALANVVPCSQWDEL-ARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFR 1276
Q EL + AL++V C Q L A +L+ +F L LL + +E+ + D TLFR
Sbjct: 732 QKELHVVYALSHV--CGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFR 789
Query: 1277 GNSLASKIMTFCFKVYGATYLQKLL-DPLLRIVITSSDWQHVSFEVDPTRLEPSESLEEN 1335
+LAS +M K ++ L D +L+I+ + S E+ P++LE +E + N
Sbjct: 790 ATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ-----SCELSPSKLEKNEDVNTN 844
Query: 1336 QRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS---IGAVGSAMFLRF 1392
+LL + + I +S PP LR + CL + V ++P N+ V +FLR
Sbjct: 845 LTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRL 904
Query: 1393 INPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNF 1451
I PAI++P I+ P P R L L++K +Q++AN V F KE +M N F+KSN
Sbjct: 905 ICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNK 964
Query: 1452 DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNR 1505
F ++ + D HS + +S ++ ALH + + +++ + LS+ R
Sbjct: 965 HRMIMFLDELGNVPELPDTTEHSRTDLS-RDLAALHEICVAHSDEL-RTLSNER 1016
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 112 bits (281), Expect = 4e-24
Identities = 90/294 (30%), Positives = 147/294 (50%), Gaps = 15/294 (5%)
Query: 1218 QGELPIAMALANVVPCSQWDEL-ARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFR 1276
Q EL + AL++V C Q L A +L+ +F L LL + +E+ + D TLFR
Sbjct: 555 QKELHVVYALSHV--CGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFR 612
Query: 1277 GNSLASKIMTFCFKVYGATYLQKLL-DPLLRIVITSSDWQHVSFEVDPTRLEPSESLEEN 1335
+LAS +M K ++ L D +L+I+ + S E+ P++LE +E + N
Sbjct: 613 ATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ-----SCELSPSKLEKNEDVNTN 667
Query: 1336 QRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS---IGAVGSAMFLRF 1392
+LL + + I +S PP LR + CL + V ++P N+ V +FLR
Sbjct: 668 LTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRL 727
Query: 1393 INPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNF 1451
I PAI++P I+ P P R L L++K +Q++AN V F KE +M N F+KSN
Sbjct: 728 ICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNK 787
Query: 1452 DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNR 1505
F ++ + D HS + +S ++ ALH + + +++ + LS+ R
Sbjct: 788 HRMIMFLDELGNVPELPDTTEHSRTDLS-RDLAALHEICVAHSDEL-RTLSNER 839
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 108 bits (270), Expect = 7e-23
Identities = 88/293 (30%), Positives = 143/293 (48%), Gaps = 14/293 (4%)
Query: 1203 DRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS 1262
++++ E VT + L V+ +ELA LV + S L ++
Sbjct: 447 EQYKEFAEFVT----SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 502
Query: 1263 KEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
EV+ L FR N++A+K + K+ G YL L ++ + S + + EV
Sbjct: 503 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE----NCEV 558
Query: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-S 1380
DP++ SE L ++Q NL E F II+S FP +L+ V Q R Q+ S
Sbjct: 559 DPSKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS 617
Query: 1381 IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEH 1439
+ +++FLRF+ PAI+SP ++ + P R R L L++K++Q++AN F KEE+
Sbjct: 618 ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEY 677
Query: 1440 MRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLA-LHRLLW 1491
M NDF++ + +RF L+I++ S+ +I G L+ LH LLW
Sbjct: 678 MAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFD-GYIDLGRELSVLHSLLW 729
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 108 bits (270), Expect = 7e-23
Identities = 88/293 (30%), Positives = 143/293 (48%), Gaps = 14/293 (4%)
Query: 1203 DRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS 1262
++++ E VT + L V+ +ELA LV + S L ++
Sbjct: 299 EQYKEFAEFVT----SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVM 354
Query: 1263 KEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
EV+ L FR N++A+K + K+ G YL L ++ + S + + EV
Sbjct: 355 SEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE----NCEV 410
Query: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-S 1380
DP++ SE L ++Q NL E F II+S FP +L+ V Q R Q+ S
Sbjct: 411 DPSKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDIS 469
Query: 1381 IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEH 1439
+ +++FLRF+ PAI+SP ++ + P R R L L++K++Q++AN F KEE+
Sbjct: 470 ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEY 529
Query: 1440 MRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLA-LHRLLW 1491
M NDF++ + +RF L+I++ S+ +I G L+ LH LLW
Sbjct: 530 MAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFD-GYIDLGRELSVLHSLLW 581
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 107 bits (268), Expect = 1e-22
Identities = 81/258 (31%), Positives = 123/258 (47%), Gaps = 14/258 (5%)
Query: 1222 PIAMALANVVP--CSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNS 1279
P++ + A+++ C + E A LV LF + + + S EV+ T+FRGNS
Sbjct: 315 PVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNS 374
Query: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
LASK + K+ G YL L P + + S H E+DP +L+ E+LE N NL
Sbjct: 375 LASKCIDETMKLAGMHYLHVTLKPAIEEICQS----HKPCEIDPVKLKDGENLENNMENL 430
Query: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRF---PQNSIGAVGSAMFLRFINPA 1396
Q ++ FHAI S P + + L + ++RF P AV S +FLRF PA
Sbjct: 431 RQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPA 490
Query: 1397 IVSPYEAGILDKKPPPRIERGLKLMSKILQSIA----NHVLFTKEEHMRPFNDFV-KSNF 1451
I+SP + P+ R L L+SK +Q++ + KE +M F +F + +
Sbjct: 491 ILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 550
Query: 1452 DAARRFFLDIASDCPTSD 1469
A + FLD+ S D
Sbjct: 551 ADAVKNFLDLISSSGRRD 568
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 100 bits (250), Expect = 2e-20
Identities = 68/219 (31%), Positives = 112/219 (51%), Gaps = 16/219 (7%)
Query: 1264 EVELADSMQ--TLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEV 1321
E++L D+ T+FRGNSLA++ + K+ G YL+ L P+L + SS S E+
Sbjct: 383 ELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSK----SCEI 438
Query: 1322 DPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-- 1379
DP +L+ +++E N+ NL +K F+ I+ SS P + + + L Q+ +QRFP +
Sbjct: 439 DPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH 498
Query: 1380 -SIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFTKEE 1438
AV S +FLRF A+VSP+ + P + R L L+SK +Q++ + +K +
Sbjct: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558
Query: 1439 H-------MRPFNDFVKSNFDAARRFFLDIASDCPTSDA 1470
F F + + A + FLD S T ++
Sbjct: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKES 597
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 95.1 bits (235), Expect = 9e-19
Identities = 78/262 (29%), Positives = 136/262 (51%), Gaps = 16/262 (6%)
Query: 1237 DELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNSLASKIMTFCFKVYGAT 1295
+E+A LV + S L +M EV+ + +FR N+LA+K + ++ G
Sbjct: 445 EEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQK 504
Query: 1296 YLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSS 1355
YL+ + +R + S + + EVDP + S SL E+Q NL E +++S
Sbjct: 505 YLKDAIGEFIRALYESEE----NCEVDPIKCTAS-SLAEHQANLRMCCELALCKVVNSHC 559
Query: 1356 EFPPQLRSVCHCLYQVVSQRFPQNSIGAVGSA-MFLRFINPAIVSPYEAGILDKKPPPRI 1414
FP +L+ V ++R ++ + SA +FLRF+ PAI+SP G++ + P +
Sbjct: 560 VFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQT 619
Query: 1415 ERGLKLMSKILQSIANHVLFT-KEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNH 1473
R L L++K++Q++AN FT KE+ + N+F++ + + ++F +I++ D + +
Sbjct: 620 SRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN----LDTLTN 675
Query: 1474 SLSF---ISDGNVLA-LHRLLW 1491
S SF I G L+ LH LLW
Sbjct: 676 SSSFEGYIDLGRELSTLHALLW 697
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 87.8 bits (216), Expect = 1e-16
Identities = 74/265 (27%), Positives = 131/265 (49%), Gaps = 14/265 (5%)
Query: 1202 ADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMF 1261
++R++ L E +T + + AL +P +ELA +V + + L+ ++
Sbjct: 429 SERYKELAEFLTFHYAR----LCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLG 484
Query: 1262 SKEVELADSMQTL-FRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE 1320
+ E+ + L FR N+LA+K + K+ YLQ+ L ++R + S++ E
Sbjct: 485 TAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTE----DCE 540
Query: 1321 VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS 1380
VDP++ P+ L E+Q L E+ F II S FP +L V + +R +
Sbjct: 541 VDPSKC-PASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSE-V 598
Query: 1381 IGA--VGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKE 1437
+G V +++FLR + PAI++P G+ P P R L L++K++Q++AN F KE
Sbjct: 599 LGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKE 658
Query: 1438 EHMRPFNDFVKSNFDAARRFFLDIA 1462
+M N F++ + A + F +A
Sbjct: 659 AYMGFMNSFLEEHGPAMQCFLDQVA 683
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 85.9 bits (211), Expect = 5e-16
Identities = 74/242 (30%), Positives = 106/242 (43%), Gaps = 26/242 (10%)
Query: 1238 ELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYL 1297
+LA LV LF R L L + +EV TLFR NSLASK M K+ G YL
Sbjct: 304 DLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYL 363
Query: 1298 QKLLDPLLRIVITSSDWQHVSFEVDPTRLE-------------PSESLEENQRNLLQ-MT 1343
++L P++ V + E+DP +++ E + E LL
Sbjct: 364 HEVLKPVISRVFEEKKY----MELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYL 419
Query: 1344 EKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQN-----SIGAVGSAMFLRFINPAIV 1398
AI+ S PP +R L++ V +RFPQ A+ +FLRF PAI+
Sbjct: 420 GPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAIL 479
Query: 1399 SPYEAGILDKKPPPRIERGLKLMSKILQSIAN---HVLFTKEEHMRPFNDFVKSNFDAAR 1455
+P + D+ P+ R L L++K +QSI N + KE M P + F+ R
Sbjct: 480 TPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVR 539
Query: 1456 RF 1457
F
Sbjct: 540 DF 541
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 79.3 bits (194), Expect = 5e-14
Identities = 78/286 (27%), Positives = 122/286 (42%), Gaps = 30/286 (10%)
Query: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 261 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 320
Query: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
L +F E+ TLFR NSLASK M KV G YL +L P++ V
Sbjct: 321 KDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKK 380
Query: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 381 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 436
Query: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 437 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 496
Query: 1415 ERGLKLMSKILQSIAN---HVLFTKEEHMRPFNDFVKSNFDAARRF 1457
R L L++K +Q++ N KE M P V+ + F
Sbjct: 497 SRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 79.3 bits (194), Expect = 5e-14
Identities = 78/286 (27%), Positives = 122/286 (42%), Gaps = 30/286 (10%)
Query: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 261 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 320
Query: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
L +F E+ TLFR NSLASK M KV G YL +L P++ V
Sbjct: 321 KDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKK 380
Query: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 381 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 436
Query: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 437 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 496
Query: 1415 ERGLKLMSKILQSIAN---HVLFTKEEHMRPFNDFVKSNFDAARRF 1457
R L L++K +Q++ N KE M P V+ + F
Sbjct: 497 SRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 77.0 bits (188), Expect = 2e-13
Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%)
Query: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 189 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248
Query: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
L +F E+ TLFR NSLASK + KV G YL +L P++ V
Sbjct: 249 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308
Query: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 309 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364
Query: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 365 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 424
Query: 1415 ERGLKLMSKILQSIAN 1430
R L L++K +Q++ N
Sbjct: 425 SRTLLLLAKAVQNVGN 440
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 77.0 bits (188), Expect = 2e-13
Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%)
Query: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 261 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 320
Query: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
L +F E+ TLFR NSLASK + KV G YL +L P++ V
Sbjct: 321 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 380
Query: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 381 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 436
Query: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 437 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 496
Query: 1415 ERGLKLMSKILQSIAN 1430
R L L++K +Q++ N
Sbjct: 497 SRTLLLLAKAVQNVGN 512
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 77.0 bits (188), Expect = 2e-13
Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%)
Query: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 189 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248
Query: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
L +F E+ TLFR NSLASK + KV G YL +L P++ V
Sbjct: 249 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308
Query: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 309 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364
Query: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 365 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 424
Query: 1415 ERGLKLMSKILQSIAN 1430
R L L++K +Q++ N
Sbjct: 425 SRTLLLLAKAVQNVGN 440
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 77.0 bits (188), Expect = 2e-13
Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%)
Query: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253
ETVL + ++ LV L+ +G QG + + ++A L+ LF + L
Sbjct: 261 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 320
Query: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313
L +F E+ TLFR NSLASK + KV G YL +L P++ V
Sbjct: 321 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 380
Query: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359
+ E+DP+++E +E LE++ + L A+ S P
Sbjct: 381 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 436
Query: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414
+R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R
Sbjct: 437 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 496
Query: 1415 ERGLKLMSKILQSIAN 1430
R L L++K +Q++ N
Sbjct: 497 SRTLLLLAKAVQNVGN 512
>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
sapiens]
Length = 1575
Score = 76.3 bits (186), Expect = 4e-13
Identities = 76/313 (24%), Positives = 140/313 (44%), Gaps = 58/313 (18%)
Query: 1242 VLVTLFD------SRHLLYQLLWNMFSKEVEL-ADSMQTLFRGNSLASK-IMTFCFKVYG 1293
V+ TL++ +LL +L +E++ D +Q + GN K +++F G
Sbjct: 918 VIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARG 977
Query: 1294 ATYLQKLLDPLLRIVITSSD-------------WQH---------------VSFEVDPTR 1325
L++LL P+++ +I W + V+ E T
Sbjct: 978 QNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTY 1037
Query: 1326 LEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS----I 1381
E LE + NL ++T+K ++IISS P LR + L + ++FP + +
Sbjct: 1038 PEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELL 1097
Query: 1382 GAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFTKE 1437
VG+ ++ R++NPAIV+P I+D +I R L ++K+LQ A++ LF E
Sbjct: 1098 KIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGE 1157
Query: 1438 -EHMRPFNDFVKSNFDAARRFFLDIASDCPTSD------------AVNHSLSFISDGNVL 1484
EH+ N+++ + R++F + A + P + V+ + +IS ++
Sbjct: 1158 NEHLSSMNNYLSETYQEFRKYFKE-ACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEII 1216
Query: 1485 ALHRLLWNNQEKI 1497
+ H LL +Q+ I
Sbjct: 1217 STHSLLLEHQDAI 1229
>gi|4506787 IQ motif containing GTPase activating protein 1 [Homo
sapiens]
Length = 1657
Score = 75.5 bits (184), Expect = 7e-13
Identities = 73/313 (23%), Positives = 140/313 (44%), Gaps = 58/313 (18%)
Query: 1242 VLVTLFD------SRHLLYQLLWNMFSKEVEL-ADSMQTLFRGNSLASK-IMTFCFKVYG 1293
V+ TL++ +LL +L +E++ D +Q + GN K +++F G
Sbjct: 1005 VIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARG 1064
Query: 1294 ATYLQKLLDPLLRIVITSSDWQHVSFEVD-------------------PTRLEPSESLEE 1334
L+++L P+++ ++ + VD P + P ++L
Sbjct: 1065 QNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAH 1124
Query: 1335 NQ---------RNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFP----QNSI 1381
+ RN+ +T+KF AI+SS + P +R + L + ++FP +
Sbjct: 1125 EEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELL 1184
Query: 1382 GAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFTKE 1437
+G+ ++ R++NPAIV+P I+D ++ R L ++K+LQ A++ +F +
Sbjct: 1185 KIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGD 1244
Query: 1438 E-HMRPFNDFVKSNFDAARRFFLDIASDCPT----------SDAV--NHSLSFISDGNVL 1484
H+ N+++ ++ RRFF A D P SD V + +IS G ++
Sbjct: 1245 NAHLSIINEYLSQSYQKFRRFF-QTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEII 1303
Query: 1485 ALHRLLWNNQEKI 1497
H LL ++Q+ I
Sbjct: 1304 NTHTLLLDHQDAI 1316
>gi|39753961 IQ motif containing GTPase activating protein 3 [Homo
sapiens]
Length = 1631
Score = 67.8 bits (164), Expect = 1e-10
Identities = 72/300 (24%), Positives = 131/300 (43%), Gaps = 56/300 (18%)
Query: 1251 HLLYQLLWNMFSKEVEL-ADSMQTLFRGN-SLASKIMTFCFKVYGATYLQKLLDPLLRIV 1308
+LL QL +E++ + Q + GN ++ ++ F G + LQ++L +++ V
Sbjct: 1004 YLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDV 1063
Query: 1309 ITSS-------------DW-----------QHVSFEVDPTRL----EPSESLEENQRNLL 1340
+ +W H+ ++V P + E L+ RNLL
Sbjct: 1064 LEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLL 1123
Query: 1341 QMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS----IGAVGSAMFLRFINPA 1396
MT+KF AI SS + P +R V L ++++FP + VG+ ++ RF+NPA
Sbjct: 1124 AMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPA 1183
Query: 1397 IVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFT-KEEHMRPFNDFVKSNF 1451
+V+P I+ + L ++++LQ A F+ + +H+R ND+++
Sbjct: 1184 VVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETH 1243
Query: 1452 --------------DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKI 1497
+ RF +D SD AV + +I+ G ++ HRLL +Q+ I
Sbjct: 1244 LKFRKFIHRACQVPEPEERFAVDEYSDMV---AVAKPMVYITVGELVNTHRLLLEHQDCI 1300
>gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo
sapiens]
Length = 1487
Score = 47.0 bits (110), Expect = 3e-04
Identities = 61/260 (23%), Positives = 108/260 (41%), Gaps = 51/260 (19%)
Query: 1253 LYQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLL-------DPLL 1305
L Q+L + E++ +D+ + L R + A I+ FK++ L +P++
Sbjct: 149 LLQVLRYLIEFELKESDNPRRLLRRGTCAFSIL---FKLFSEGLFSAKLFLTATLHEPIM 205
Query: 1306 RIVITSSDWQHVSFEVDPTRL----EPS-------------------ESLEENQRNLLQM 1342
++++ D E DP +L PS E +E N+ L+ +
Sbjct: 206 QLLVEDED----HLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVAL 261
Query: 1343 TEKFFHAIISSSSEFPPQLRSVCHCLYQVVS--QRFPQNSIGAVGSAMFLR-FINPAIVS 1399
KF + ++ FP LR + +Y+ +S R + A+ + + L FI PA+V+
Sbjct: 262 VNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVN 321
Query: 1400 PYEAGILDKKPPPRIER-GLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFD-AARRF 1457
P + GI+ P + R L + ++LQ +A T E P FD +
Sbjct: 322 PEQYGIISDAPINEVARFNLMQVGRLLQQLA----MTGSEEGDPRTKSSLGKFDKSCVAA 377
Query: 1458 FLDI-----ASDCPTSDAVN 1472
FLD+ A + P +VN
Sbjct: 378 FLDVVIGGRAVETPPLSSVN 397
>gi|207450721 ganglioside induced differentiation associated protein 2
isoform b [Homo sapiens]
Length = 496
Score = 40.4 bits (93), Expect = 0.025
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 5/159 (3%)
Query: 1561 EEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEI 1620
E+ + +L YQ G G + V R I+ D + + + + K Y +
Sbjct: 329 EDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVL 388
Query: 1621 VVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERL-LTGL 1679
V T T N +DFL K + V N+ AVY + + T + ++GL
Sbjct: 389 VYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGL 448
Query: 1680 KGSKRLVFIDCPGKLAEHIEHEQQKLPAATLALEEDLKV 1718
K ++ +D +L I EQ P LE D +V
Sbjct: 449 K--DKIHHVDSLHQLFSAISPEQIDFP--PFVLEYDARV 483
>gi|8923143 ganglioside induced differentiation associated protein 2
isoform a [Homo sapiens]
Length = 497
Score = 39.3 bits (90), Expect = 0.056
Identities = 36/151 (23%), Positives = 58/151 (38%), Gaps = 3/151 (1%)
Query: 1561 EEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPYEI 1620
E+ + +L YQ G G + V R I+ D + + + + K Y +
Sbjct: 329 EDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVL 388
Query: 1621 VVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERL-LTGL 1679
V T T N +DFL K + V N+ AVY + + T + ++GL
Sbjct: 389 VYFHTLTSEYNHLDSDFLKKLYDVVDVKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGL 448
Query: 1680 KGSKRLVFIDCPGKLAEHIEHEQQKLPAATL 1710
K ++ +D +L I EQ P L
Sbjct: 449 K--DKIHHVDSLHQLFSAISPEQIDFPPFVL 477
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 33.9 bits (76), Expect = 2.3
Identities = 62/285 (21%), Positives = 109/285 (38%), Gaps = 34/285 (11%)
Query: 2100 STHGLVINIIHSLCT-CSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFR 2158
ST G + +IH+ T QL +E R+SL ++ + +F+ + + +I+
Sbjct: 1049 STEGQELEVIHTTLTGLKQLLIIDED---FRISLFQY-MSQFFNSSVEDLLDNKCLISDN 1104
Query: 2159 SSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTE----LAQR 2214
++S F L + + A + + M T WL WTE ++Q
Sbjct: 1105 KHISSVNYSTSEESSFVFPLAQIFSNLSANVSVFNKFMSIHCTVSWLQMWTEIWETISQL 1164
Query: 2215 FAFQYNPSLQPRALVVFGCISKRVSHG--QIKQIIRILSKALESCLKGPDTYNSQVLIEA 2272
F F N + + HG Q+ + K +SC T+N LI
Sbjct: 1165 FKFDMN-------------VFTSLHHGFTQLLDELEDDVKVSKSCQGILPTHNVARLILN 1211
Query: 2273 TVIALTKLQPLLNKDSPLHKALFWVAV--AVLQLDEVNLYSAGTAL--LEQNLHTLDSLR 2328
+T+ N + L F VA+ A++ + ++NL +L +E LH L +
Sbjct: 1212 LFKNVTQANDFHNWEDFLDLRDFLVALGNALVSVKKLNLEQVEKSLFTMEAALHQLKTFP 1271
Query: 2329 IFNDKSPE------EVFMAIRNPLEWHCKQMDHFVGLNFNSNFNF 2367
S E EVF+ + E+ + +D N+ N+
Sbjct: 1272 FNESTSREFLNSLLEVFIEFSSTSEYIVRNLDSINDFLSNNLTNY 1316
>gi|117606355 furry homolog [Homo sapiens]
Length = 3013
Score = 33.5 bits (75), Expect = 3.0
Identities = 26/111 (23%), Positives = 47/111 (42%), Gaps = 7/111 (6%)
Query: 1832 TLLNIALLNLGSSDPSLRSAAYNLLCALTC---TFNLKIE----GQLLETSGLCIPANNT 1884
TLLN+ L ++ + + L+ L ++ K+ G +L + +P +
Sbjct: 1257 TLLNLVLFKASDTNREIYEISMQLMQILEAKLFVYSKKVAEQRPGSILYGTHGPLPPLYS 1316
Query: 1885 LFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNL 1935
+ + +S LA P LTL E F + + + L Y+ PWL N+
Sbjct: 1317 VSLALLSCELARMYPELTLPLFSEVSQRFPTTHPNGRQIMLTYLLPWLHNI 1367
>gi|119874201 furry-like [Homo sapiens]
Length = 3013
Score = 33.1 bits (74), Expect = 4.0
Identities = 27/109 (24%), Positives = 45/109 (41%), Gaps = 6/109 (5%)
Query: 1833 LLNIALLNLGSSDPSLRSAAYNLLCALTCT-FNLKIEGQLLETSGLC-----IPANNTLF 1886
LLN+ L S S+ A LL L F + ++ T G+ +P ++
Sbjct: 1208 LLNLILFKAADSSRSIYEVAMQLLQILEPKMFRYAHKLEVQRTDGVLSQLSPLPHLYSVS 1267
Query: 1887 IVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNL 1935
+S+ LA P LTL E + + + L Y+ PW++N+
Sbjct: 1268 YYQLSEELARAYPELTLAIFSEISQRIQTAHPAGRQVMLHYLLPWMNNI 1316
>gi|66529407 tensin [Homo sapiens]
Length = 1735
Score = 33.1 bits (74), Expect = 4.0
Identities = 15/47 (31%), Positives = 22/47 (46%)
Query: 635 PSSGNTSQMSMDHEELLRTPGASLRKGKGNSSMDSAAGCSGTPPICR 681
PS S S+ H +++ PG +S SAA G+P +CR
Sbjct: 1202 PSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCR 1248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,099,469
Number of Sequences: 37866
Number of extensions: 4282722
Number of successful extensions: 10677
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 10547
Number of HSP's gapped (non-prelim): 106
length of query: 2818
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2698
effective length of database: 13,703,598
effective search space: 36972307404
effective search space used: 36972307404
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.