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Search of human proteins with 45430055
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45430055 translokin [Homo sapiens]
(500 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45430055 translokin [Homo sapiens] 971 0.0
gi|134133246 hypothetical protein LOC285753 [Homo sapiens] 242 7e-64
gi|28603844 hypothetical protein LOC285753 [Homo sapiens] 242 7e-64
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 71 3e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 71 3e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 70 3e-12
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 67 4e-11
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 67 4e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 66 6e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 65 1e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 65 2e-10
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 65 2e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 61 2e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 60 4e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 60 5e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 60 5e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 60 5e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 60 5e-09
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 60 5e-09
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 60 6e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 60 6e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 60 6e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 59 8e-09
gi|21735548 centrosomal protein 2 [Homo sapiens] 59 8e-09
gi|38044112 restin isoform b [Homo sapiens] 59 1e-08
gi|4506751 restin isoform a [Homo sapiens] 59 1e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 59 1e-08
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 59 1e-08
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 59 1e-08
gi|42794779 myosin 18A isoform b [Homo sapiens] 59 1e-08
>gi|45430055 translokin [Homo sapiens]
Length = 500
Score = 971 bits (2509), Expect = 0.0
Identities = 500/500 (100%), Positives = 500/500 (100%)
Query: 1 MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLA 60
MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLA
Sbjct: 1 MAAASVSAASGSHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLA 60
Query: 61 YPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKN 120
YPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKN
Sbjct: 61 YPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKN 120
Query: 121 EESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQT 180
EESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQT
Sbjct: 121 EESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQT 180
Query: 181 HVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLET 240
HVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLET
Sbjct: 181 HVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLET 240
Query: 241 NRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPS 300
NRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPS
Sbjct: 241 NRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPS 300
Query: 301 HAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEEL 360
HAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEEL
Sbjct: 301 HAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEEL 360
Query: 361 SEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRK 420
SEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRK
Sbjct: 361 SEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRK 420
Query: 421 YQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQL 480
YQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQL
Sbjct: 421 YQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQL 480
Query: 481 LKDMQSIQNSLQSSSLCWDY 500
LKDMQSIQNSLQSSSLCWDY
Sbjct: 481 LKDMQSIQNSLQSSSLCWDY 500
>gi|134133246 hypothetical protein LOC285753 [Homo sapiens]
Length = 460
Score = 242 bits (617), Expect = 7e-64
Identities = 146/403 (36%), Positives = 225/403 (55%), Gaps = 33/403 (8%)
Query: 65 NSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESK 124
NS+A+ ALK LQ+KI RLELER QAE+++ LSRE +YKK L+ + ER + E K
Sbjct: 51 NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK 110
Query: 125 HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS 184
++++ QL +A+++C LLEKQLEY + M+ + E E+ +LE+Q L+RE++ DQ + +
Sbjct: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
Query: 185 QLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244
+LEKLD+LE+E +LTT Q AE K++ LE KL EEE +RK Q KA+ELQTGLE +++I
Sbjct: 171 KLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKII 230
Query: 245 FEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLC--LGDMPFVAGKSTSPSHA 302
V N + K+KK + K + +P +++C G +PFVA K
Sbjct: 231 MSS-----VSNLKHSKEKKKSSKKTKCIKR----RPPWQICSKFGALPFVAEK------- 274
Query: 303 VVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSN---GINEE 359
M+QH + N + + + + PP S I +
Sbjct: 275 -----------MRQHRDPHILQKPFN-VTETRCLPKPSRTTSWCKAIPPDSEKSISICDN 322
Query: 360 LSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVR 419
LSE+L +QDE QMS +HQ+L K ++E+ + + D +ECELE L+ +ME K QI+K++
Sbjct: 323 LSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK 382
Query: 420 KYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNK 462
K+Q + K + + Q ++ E+ I + K
Sbjct: 383 KHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
>gi|28603844 hypothetical protein LOC285753 [Homo sapiens]
Length = 460
Score = 242 bits (617), Expect = 7e-64
Identities = 146/403 (36%), Positives = 225/403 (55%), Gaps = 33/403 (8%)
Query: 65 NSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESK 124
NS+A+ ALK LQ+KI RLELER QAE+++ LSRE +YKK L+ + ER + E K
Sbjct: 51 NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK 110
Query: 125 HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS 184
++++ QL +A+++C LLEKQLEY + M+ + E E+ +LE+Q L+RE++ DQ + +
Sbjct: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
Query: 185 QLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244
+LEKLD+LE+E +LTT Q AE K++ LE KL EEE +RK Q KA+ELQTGLE +++I
Sbjct: 171 KLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKII 230
Query: 245 FEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLC--LGDMPFVAGKSTSPSHA 302
V N + K+KK + K + +P +++C G +PFVA K
Sbjct: 231 MSS-----VSNLKHSKEKKKSSKKTKCIKR----RPPWQICSKFGALPFVAEK------- 274
Query: 303 VVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSN---GINEE 359
M+QH + N + + + + PP S I +
Sbjct: 275 -----------MRQHRDPHILQKPFN-VTETRCLPKPSRTTSWCKAIPPDSEKSISICDN 322
Query: 360 LSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVR 419
LSE+L +QDE QMS +HQ+L K ++E+ + + D +ECELE L+ +ME K QI+K++
Sbjct: 323 LSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK 382
Query: 420 KYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNK 462
K+Q + K + + Q ++ E+ I + K
Sbjct: 383 KHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 70.9 bits (172), Expect = 3e-12
Identities = 112/481 (23%), Positives = 216/481 (44%), Gaps = 60/481 (12%)
Query: 51 RRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDE 110
+R K Y E RA + L++++ LE E ++ + L + T E + L++
Sbjct: 610 KRQIKKELEHYKEKGERA-----EELENELHHLEKENELLQKKITNL-KITCEKIEALEQ 663
Query: 111 QIQE--RENSKNEESKHN-QELTSQLLAAENKCNLL-EKQLEYMRNM--IKHAEMERTSV 164
+ E REN K +++ + + LT QL + E + + L E+ LE RN+ +K A M+ +
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 165 LEKQVSLERERQHDQTHVQ------SQLEKLDL----LEQEYNKLTTMQALAEKKMQELE 214
+ LE E++ + ++ + E+L++ L+ E +L + KK+Q+LE
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 215 AKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRN 274
++L + E E + +Q EL+ + + RL +K + +K K EK++ R
Sbjct: 784 SELQDLEMENQTLQKNLEELK--ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 275 YFGAQ------PHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVIN 328
A+ + +G++ K+ S + + L +++ +K L I+
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLE-KENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 329 S---IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLA--- 382
+ L + + S K++++ N E+L+ L+ + ++ D Q
Sbjct: 901 IKTLVTLREDLVSEKLKTQQM-------NNDLEKLTHELEKIGLNKERLLHDEQSTDDRY 953
Query: 383 KLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKK 442
KL++ LK LE + E + +EA+ + T Y QL +Q+L+ KK +A K+
Sbjct: 954 KLLESKLESTLKKSLEIK-EEKIAALEARLEESTN---YNQQL-RQELKTVKKNYEALKQ 1008
Query: 443 TLDEERNSSSRSGITGTTNK---------KDFMKLRPG--EKRRKNLQLLKDMQSIQNSL 491
DEER S I+G NK ++ +K++ E R N L + Q+++ L
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1068
Query: 492 Q 492
+
Sbjct: 1069 K 1069
Score = 57.0 bits (136), Expect = 4e-08
Identities = 93/414 (22%), Positives = 182/414 (43%), Gaps = 71/414 (17%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTS 131
+L+N Q+ + L E+ Q E++++TL + K+L E+EN ++ + S
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL-----EQENEHLNQTVSSLRQRS 574
Query: 132 QLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDL 191
Q ++AE + +EK+ + + IK E +S L K +R+ + + H + + E+ +
Sbjct: 575 Q-ISAEARVKDIEKENKILHESIK----ETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 192 LEQEYNKLTTMQALAEKKMQELE---AKLHEEEQERKRMQAKAAELQTGLET-NRLIFED 247
LE E + L L +KK+ L+ K+ EQE ++ + +L+ L++ L F+
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ- 688
Query: 248 KATPCVPNARRIKKKKSKPPEK--KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVA 305
++K+ S+ E+ + RN +S + +A
Sbjct: 689 --------LESLEKENSQLDEENLELRRNV-------------------ESLKCASMKMA 721
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
+QL +K L +++ L K + KK S G++ E + +
Sbjct: 722 QLQL-------ENKELESEKE----QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
TL++ ++ QQL +Q+ LE E + L +E +I+ R Q +
Sbjct: 771 TLENSNKKI----QQLESELQD---------LEMENQTLQKNLEEL--KISSKRLEQLEK 815
Query: 426 EKQKLEKQKKELKATKKTLDEE-RNSSSRSGITGTTNKKDFMKLRPGEKRRKNL 478
E + LE++ +L+ KK L++E + ++ I TT +++ +K+ EK K L
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Score = 54.3 bits (129), Expect = 3e-07
Identities = 100/491 (20%), Positives = 197/491 (40%), Gaps = 59/491 (12%)
Query: 47 NSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYK- 105
NS+L R K + + KNL ++ LE E Q +E L R K
Sbjct: 665 NSELERENRK---------LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
Query: 106 ---KVLDEQIQERE-NSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM----RNMIKHA 157
K+ Q++ +E S+ E+ K EL L A+ K LE + + + + K
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLEL---LKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 158 EMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKL 217
E + + + L+ +QT +Q LE+L + + +L E++ +LE
Sbjct: 773 ENSNKKIQQLESELQDLEMENQT-LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 218 HEEEQERKRMQAKAAELQTGLETNRLIFE--DKATPCVPNARRIKKK---KSKPPEKKSS 272
+ E+E KR++ +A T LE N + +K + I K+ + K EK++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 273 RNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQ---------HSKALCN 323
A + + + + + + +++ + H +++ H + +
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLK-TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
Query: 324 DR--VINS---IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDH 378
DR ++ S L K + + K L S N++L + L+T++ + +
Sbjct: 951 DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK-QR 1009
Query: 379 QQLAKLIQESPTVELKD-KLECELEALVGRMEAKANQITKVRKYQA--QLEKQKLEKQKK 435
Q +++Q SP + +D K E E + + +++ +V + A Q EKQ L+ Q K
Sbjct: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069
Query: 436 ELKATKKTLD-------------EERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLK 482
+L+ L +E+N++ ++ + + + +N QLL
Sbjct: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Query: 483 DMQSIQNSLQS 493
S++N +S
Sbjct: 1130 QQSSLENENES 1140
Score = 53.9 bits (128), Expect = 3e-07
Identities = 89/450 (19%), Positives = 179/450 (39%), Gaps = 62/450 (13%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
K+L ++ L R+ E +T+E + + ++ + + K NQ L+ ++
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
EN+ ++ L+ +N+ K M+ + LEK + RE Q + +LE
Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDL-MKEKAQLEKTIETLRENSERQ---------IKILE 557
Query: 194 QEYNKLT-TMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPC 252
QE L T+ +L ++ EA++ + E+E K + E T + +++ FE
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE--TSSKLSKIEFE------ 609
Query: 253 VPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLV-- 310
R+IKK+ EK + H+ K + N+++
Sbjct: 610 ---KRQIKKELEHYKEKGERAEELENELHH----------LEKENELLQKKITNLKITCE 656
Query: 311 -LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQD 369
+ ++Q + L + + L K + S + +L ++ ++EE E+ + ++
Sbjct: 657 KIEALEQENSELERE----NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 370 -EFGQMSFDHQQLAKLIQESPTVELKDKLEC---------ELEALVGRMEAKANQITKV- 418
+ M QL ES +LK LE LE ++ + ++ K
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 419 ----RKYQ--------AQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFM 466
+K Q ++E Q L+K +ELK + K L++ + + +KD
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 467 KLRPGEKRRKNLQLLKDMQSIQNSLQSSSL 496
+L KR + +KD +N+++ +L
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Score = 47.4 bits (111), Expect = 3e-05
Identities = 41/170 (24%), Positives = 82/170 (48%), Gaps = 12/170 (7%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKC 140
+ L +E A+ ++ L +E E + L + QE E + E + QE LL+
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE-NMNLLSDARSA 305
Query: 141 NLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLT 200
+ +L+ +R + R LE +VS +ER HD ++++E+L +++ L
Sbjct: 306 RMYRDELDALRE-----KAVRVDKLESEVSRYKERLHDIEFYKARVEEL---KEDNQVLL 357
Query: 201 TMQALAEKKMQELEA---KLHEEEQERKRMQAKAAELQTGLETNRLIFED 247
+ + E +++ A KLHE E+E +++AK +++ + +R E+
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE 407
Score = 42.7 bits (99), Expect = 8e-04
Identities = 86/428 (20%), Positives = 172/428 (40%), Gaps = 54/428 (12%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLS--RETIEYKKVLDEQIQERENSKN-EESKHNQEL 129
LKN+ ++RL ER + E++ LS R+ + + Q S + ++ Q L
Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL 249
Query: 130 TSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQH---DQTHVQSQL 186
+ +L A+ K L ++LE + + E + + L++E + D +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
++LD L ++ ++ + E ++ + +LH+ E + R++ + Q LET ++ E
Sbjct: 310 DELDALREKAVRVDKL----ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML-E 364
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVAN 306
D+ R + K EK++ + + L DM ++
Sbjct: 365 DQL-----EGTRARSDKLHELEKENLQ--------LKAKLHDMEMERDMDRKKIEELMEE 411
Query: 307 VQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQT 366
+ L + ++ S D ++ +Q+S ++ +LS P S G EV +
Sbjct: 412 -NMTLEMAQKQSM----DESLHLGWELEQIS----RTSELSEAPQKSLG-----HEVNEL 457
Query: 367 LQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLE 426
++ ++Q L K ++ EL V +E A++I K+ K +L
Sbjct: 458 TSSRLLKLEMENQSLTKTVE-------------ELRTTVDSVEGNASKILKMEKENQRLS 504
Query: 427 KQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQS 486
K K+E + E+ K++L +N S +K LR E + +++L+
Sbjct: 505 K-KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR--ENSERQIKILEQENE 561
Query: 487 IQNSLQSS 494
N SS
Sbjct: 562 HLNQTVSS 569
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 70.9 bits (172), Expect = 3e-12
Identities = 106/463 (22%), Positives = 192/463 (41%), Gaps = 93/463 (20%)
Query: 42 DKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRET 101
+K L D + + + E N+R +Q + L+ +++ E + LS
Sbjct: 808 EKQILKQDFETLSQETKIQHEELNNR--------IQTTVTELQKVKMEKEALMTELSTVK 859
Query: 102 IEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMER 161
+ KV D +NSK+E K NQ+ + +L E C L+ QL+ +ME
Sbjct: 860 DKLSKVSDSL----KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ--------VQMEN 907
Query: 162 TSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHE-- 219
T +K++ E++ + +H Q +LE + EQ T++ EK+ Q+L+ ++E
Sbjct: 908 TLKEQKELKKSLEKEKEASH-QLKLELNSMQEQLIQAQNTLKQ-NEKEEQQLQGNINELK 965
Query: 220 --EEQERKRMQAKAAEL------QTGLETNRLIFEDKATPCVPNARRIKKK--------- 262
EQ++K+++A EL +T LE N+L + + T K+K
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELE-NKL--QQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 263 KSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALC 322
KS+ K+ +++G + D+ V K + +++N + +
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN---------- 1072
Query: 323 NDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLA 382
+++I + AK + K+ ++L E + LQD Q
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKE------------QQLQERCKALQD---------IQKE 1111
Query: 383 KLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLE--KQKKELKAT 440
K ++E V K KL E+E E K Q ++ K +L+ KLE K+ LK
Sbjct: 1112 KSLKEKELVNEKSKL-AEIE------EIKCRQEKEITKLNEELKSHKLESIKEITNLKDA 1164
Query: 441 KKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKD 483
K+ L +++ K D +K E+ ++N Q+LKD
Sbjct: 1165 KQLLIQQK--------LELQGKADSLKAAV-EQEKRNQQILKD 1198
Score = 62.0 bits (149), Expect = 1e-09
Identities = 91/430 (21%), Positives = 168/430 (39%), Gaps = 59/430 (13%)
Query: 71 SALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELT 130
+ L LQ+K L+ + Q E +K S + ++ L +Q+QE++ H +
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK-------AHLRAAQ 613
Query: 131 SQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLER----ERQHDQTHVQSQL 186
++L+ E N L QL + + +++ + E +S E +R Q H+ +
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
L +QE NK+TT K+Q+ + + E K + K L+ +T L
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ--KTEEL--- 728
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVAN 306
+IKK ++ E K+S+ L D+ N
Sbjct: 729 ---------EGQIKKLEADSLEVKASKEQ---------ALQDL----------QQQRQLN 760
Query: 307 VQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQT 366
L L + + +++S L Q S +S K +T + L + +T
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE--KQILKQDFET 818
Query: 367 LQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLE 426
L E H++L IQ TV K++ E EAL+ + ++++KV L+
Sbjct: 819 LSQE---TKIQHEELNNRIQ--TTVTELQKVKMEKEALMTELSTVKDKLSKV---SDSLK 870
Query: 427 KQKLEKQKKELKATKKTLDEERNSSS-----RSGITGTTNKKDFMKLRPGEKRRKNLQLL 481
K E +K+ K LD E+ + + T ++ +K +++ + QL
Sbjct: 871 NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930
Query: 482 KDMQSIQNSL 491
++ S+Q L
Sbjct: 931 LELNSMQEQL 940
Score = 56.6 bits (135), Expect = 5e-08
Identities = 81/408 (19%), Positives = 174/408 (42%), Gaps = 56/408 (13%)
Query: 80 IRRLELERIQAE--ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAE 137
I+ L+ E +Q E V L +E ++ + ++D ERE + ++L SQ ++E
Sbjct: 207 IQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE 266
Query: 138 NKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYN 197
+ L +L + E + + S+ Q +QT ++ L+K EQ+Y
Sbjct: 267 ATISQLRSELAKGPQEVAVYVQELQKL---KSSVNELTQKNQTLTENLLKK----EQDYT 319
Query: 198 KLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNAR 257
KL + ++A LH+++ + +++Q++ + +T L + +K
Sbjct: 320 KLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 379
Query: 258 RIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQH 317
+ + ++K K+ Q + H +QL + + H
Sbjct: 380 ELSEVETKYQHLKAEFKQLQQQ---------------REEKEQH----GLQLQSEINQLH 420
Query: 318 SKALCNDRVINS----IPLAKQVSSRG--GKSKKLSVTPPSSNGINEELSEVLQT---LQ 368
SK L +R + + +Q+SS K ++++ + + E+L E + LQ
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 369 DEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQ 428
+ + HQ+ + +Q+S T +L++ + +LE ++ ++ K K++ +A L+K
Sbjct: 481 HQLDKTKQQHQE-QQALQQSTTAKLRE-AQNDLEQVLRQIGDKDQ---KIQNLEALLQKS 535
Query: 429 K-----LEKQKKELKATKKTLD---------EERNSSSRSGITGTTNK 462
K LEK++++L A + + +E+N + + +T T K
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Score = 55.8 bits (133), Expect = 9e-08
Identities = 82/403 (20%), Positives = 170/403 (42%), Gaps = 79/403 (19%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKK---VLDEQIQERENSKNEESKHNQELT 130
+ L+D+ ++L+ + +E ++ L E + + V +++Q+ ++S NE ++ NQ LT
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 131 SQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQL---- 186
NLL+K+ +Y + KH E E S Q +L ++ D +QS+L
Sbjct: 309 E---------NLLKKEQDYTKLEEKHNE-ESVSKKNIQATL-HQKDLDCQQLQSRLSASE 357
Query: 187 --------------EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAA 232
E L++E +++ T + + ++L+ + E+EQ ++Q++
Sbjct: 358 TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN 417
Query: 233 ELQTG-LETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPF 291
+L + LET R + E R+K+++ EK +
Sbjct: 418 QLHSKLLETERQLGEAHG--------RLKEQRQLSSEKLMDK------------------ 451
Query: 292 VAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPP 351
VA++QL L +++ K ++V NS L Q+ + ++
Sbjct: 452 ---------EQQVADLQLKLSRLEEQLK----EKVTNSTELQHQLDKTKQQHQEQQALQQ 498
Query: 352 SSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQES-PTVELKDKLECELEALVGRMEA 410
S+ E L+ + + G Q L L+Q+S + L +K +L A + E
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558
Query: 411 KANQITKVRKYQAQLEKQ------KLEKQKKELKATKKTLDEE 447
+ + ++++ L++Q KL+ Q + K ++ L ++
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
Score = 50.4 bits (119), Expect = 4e-06
Identities = 102/460 (22%), Positives = 186/460 (40%), Gaps = 73/460 (15%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQ 132
L + + ++ L+L+ + EE +K + E + LD+ Q+ + E+ Q T++
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ----EQQALQQSTTAK 503
Query: 133 LLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQ---------HDQTHVQ 183
L A+N + +Q+ I++ E E LE+ER+ +T V
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 184 SQL-EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK----RMQAKAAELQTGL 238
+QL EK L+++ +LT + ++ + LH++ QE+K Q + L+T +
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 239 -ETNRLIFEDKATPC-------VPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMP 290
E N + E K + + +K ++ +N+ + L D
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN---ALQDKQ 680
Query: 291 FVAGKSTSPSHAVVANV--------QLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGK 342
K T+ V A + QL HL + K L L ++ G+
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL---------SLEQKTEELEGQ 731
Query: 343 SKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELE 402
KKL S + + LQ LQ + Q++ D E EL +LE E E
Sbjct: 732 IKKLEA---DSLEVKASKEQALQDLQQQ-RQLNTD--------LELRATELSKQLEMEKE 779
Query: 403 ALVGRMEAKANQITKVRKYQA-QLEKQKLEKQKKE---LKATKKTLDEE---RNSSSRSG 455
+ + ++ +K +A + KQKL KQ++E LK +TL +E ++ +
Sbjct: 780 IV------SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 456 ITGTTNKKDFMKLRPGEKRRKNLQLLKD-MQSIQNSLQSS 494
I T + +K+ E L +KD + + +SL++S
Sbjct: 834 IQTTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLKNS 872
Score = 49.7 bits (117), Expect = 6e-06
Identities = 94/456 (20%), Positives = 188/456 (41%), Gaps = 38/456 (8%)
Query: 56 KPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDE---QI 112
K L+ E+ + + + K LQ + E +Q + + L + +E ++ L E ++
Sbjct: 378 KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL 437
Query: 113 QERENSKNEE--SKHNQELTSQLLAAENKCNLLEK-----QLEYMRNMIKHAEMERTSVL 165
+E+ +E+ K Q QL + + L EK +L++ + K E+ ++
Sbjct: 438 KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ 497
Query: 166 EKQVSLERERQHDQTHVQSQL----EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEE 221
+ + RE Q+D V Q+ +K+ LE K +L EK+ ++L AK+ E
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557
Query: 222 QERKRMQAKAAELQTGLETNRLIFED--KATPCVPNARRIKK--KKSKPPEKKSSRNYFG 277
E A L E N + E + T + N K +++ + + + +
Sbjct: 558 GE-------TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610
Query: 278 AQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVS 337
A L L + S V+ + + + K ++ L + + A +
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI---KAKTELLLSAEAAKTAQRADLQN 667
Query: 338 SRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKL 397
L N I +L +V LQD+ S L + ++ ++E K +
Sbjct: 668 HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE- 726
Query: 398 ECELEALVGRMEAKANQITKVRKYQA--QLEKQKLEKQKKELKATK--KTLDEERN--SS 451
ELE + ++EA + ++ K K QA L++Q+ EL+AT+ K L+ E+ SS
Sbjct: 727 --ELEGQIKKLEADSLEV-KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS 783
Query: 452 SRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSI 487
+R + + + +K + ++ + L +D +++
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Score = 42.0 bits (97), Expect = 0.001
Identities = 92/429 (21%), Positives = 158/429 (36%), Gaps = 83/429 (19%)
Query: 92 ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMR 151
ES L R+ + +L +++Q+ + S EE +++EL +L EK +
Sbjct: 75 ESNLALKRDDVT---LLRQEVQDLQASLKEEKWYSEELKKEL----------EKYQGLQQ 121
Query: 152 NMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQ 211
K + S E Q SLE++ + QT + + DL EQ+ +L T ++
Sbjct: 122 QEAKPDGLVTDSSAELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT-------EIA 173
Query: 212 ELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKAT-----PCVPNARRIKK----- 261
++++K EE R+ + K L L + +D T P + + +KK
Sbjct: 174 DIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQV 233
Query: 262 ---------------KKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVAN 306
+K K KK Y ++ ++ + P V
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL------AKGPQEVAV-- 285
Query: 307 VQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQT 366
V L K S +N + Q + K+ T E +S+ +
Sbjct: 286 --YVQELQKLKSS-------VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK--KN 334
Query: 367 LQDEFGQMSFDHQQLAKLIQESPT------VELKDKLEC--ELEALVGRMEAKANQITKV 418
+Q Q D QQL + S T VEL +K E +L+ + +E K +
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE 394
Query: 419 RKYQAQLEKQKLEKQKKELKAT-------KKTLDEERNSSSRSGITGTTNKKDFMKLRPG 471
K QL++Q+ EK++ L+ K L+ ER G + KL
Sbjct: 395 FK---QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 472 EKRRKNLQL 480
E++ +LQL
Sbjct: 452 EQQVADLQL 460
Score = 40.8 bits (94), Expect = 0.003
Identities = 42/174 (24%), Positives = 77/174 (44%), Gaps = 22/174 (12%)
Query: 76 LQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLA 135
++ + R ++ + Q ++ + L +E IE + L +I+E+E + ++ +LT Q+ A
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245
Query: 136 --------------AENKCNLLEKQLEYMRNMIKHAEM-------ERTSVLEKQVSLERE 174
++ + + LEKQ + +R I E ER ++LE+ + E E
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305
Query: 175 RQHDQTHVQSQLEKLDLLEQEYNKL-TTMQALAEKKMQELEAKLHEEEQERKRM 227
+ QT V KLD +L Q+L K Q L K E+ + + M
Sbjct: 1306 IEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCM 1359
Score = 35.8 bits (81), Expect = 0.093
Identities = 44/168 (26%), Positives = 80/168 (47%), Gaps = 19/168 (11%)
Query: 71 SALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELT 130
SA K Q + R L+ IQ E+S+K +E + K L E + + + E +K N+EL
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLK--EKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
Query: 131 SQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLD 190
S L + + L+ + + + + S+ + ++E+E+++ Q ++ Q++K
Sbjct: 1149 SHKLESIKEITNLKDAKQLLIQQKLELQGKADSL---KAAVEQEKRNQQI-LKDQVKK-- 1202
Query: 191 LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL 238
E+E K K+ E EAKLH E +E++ K E + L
Sbjct: 1203 --EEEELK---------KEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 70.5 bits (171), Expect = 3e-12
Identities = 112/482 (23%), Positives = 216/482 (44%), Gaps = 61/482 (12%)
Query: 51 RRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDE 110
+R K Y E RA + L++++ LE E ++ + L + T E + L++
Sbjct: 610 KRQIKKELEHYKEKGERA-----EELENELHHLEKENELLQKKITNL-KITCEKIEALEQ 663
Query: 111 QIQE--RENSKNEESKHN-QELTSQLLAAENKCNLL-EKQLEYMRNM--IKHAEMERTSV 164
+ E REN K +++ + + LT QL + E + + L E+ LE RN+ +K A M+ +
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 165 LEKQVSLERERQHDQTHVQ------SQLEKLDL----LEQEYNKLTTMQALAEKKMQELE 214
+ LE E++ + ++ + E+L++ L+ E +L + KK+Q+LE
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 215 AKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRN 274
++L + E E + +Q EL+ + + RL +K + +K K EK++ R
Sbjct: 784 SELQDLEMENQTLQKNLEELK--ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 275 YFGAQ------PHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVIN 328
A+ + +G++ K+ S + + L +++ +K L I+
Sbjct: 842 RQQAEIKDTTLEENNVKIGNLE-KENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 329 S---IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLA--- 382
+ L + + S K++++ N E+L+ L+ + ++ D Q
Sbjct: 901 IKTLVTLREDLVSEKLKTQQM-------NNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 383 -KLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATK 441
KL++ LK LE + E + +EA+ + T Y QL +Q+L+ KK +A K
Sbjct: 954 YKLLESKLESTLKKSLEIK-EEKIAALEARLEESTN---YNQQL-RQELKTVKKNYEALK 1008
Query: 442 KTLDEERNSSSRSGITGTTNK---------KDFMKLRPG--EKRRKNLQLLKDMQSIQNS 490
+ DEER S I+G NK ++ +K++ E R N L + Q+++
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 491 LQ 492
L+
Sbjct: 1069 LK 1070
Score = 57.0 bits (136), Expect = 4e-08
Identities = 93/414 (22%), Positives = 182/414 (43%), Gaps = 71/414 (17%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTS 131
+L+N Q+ + L E+ Q E++++TL + K+L E+EN ++ + S
Sbjct: 520 SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL-----EQENEHLNQTVSSLRQRS 574
Query: 132 QLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDL 191
Q ++AE + +EK+ + + IK E +S L K +R+ + + H + + E+ +
Sbjct: 575 Q-ISAEARVKDIEKENKILHESIK----ETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 192 LEQEYNKLTTMQALAEKKMQELE---AKLHEEEQERKRMQAKAAELQTGLET-NRLIFED 247
LE E + L L +KK+ L+ K+ EQE ++ + +L+ L++ L F+
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ- 688
Query: 248 KATPCVPNARRIKKKKSKPPEK--KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVA 305
++K+ S+ E+ + RN +S + +A
Sbjct: 689 --------LESLEKENSQLDEENLELRRNV-------------------ESLKCASMKMA 721
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
+QL +K L +++ L K + KK S G++ E + +
Sbjct: 722 QLQL-------ENKELESEKE----QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
TL++ ++ QQL +Q+ LE E + L +E +I+ R Q +
Sbjct: 771 TLENSNKKI----QQLESELQD---------LEMENQTLQKNLEEL--KISSKRLEQLEK 815
Query: 426 EKQKLEKQKKELKATKKTLDEE-RNSSSRSGITGTTNKKDFMKLRPGEKRRKNL 478
E + LE++ +L+ KK L++E + ++ I TT +++ +K+ EK K L
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Score = 55.1 bits (131), Expect = 1e-07
Identities = 104/493 (21%), Positives = 192/493 (38%), Gaps = 62/493 (12%)
Query: 47 NSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYK- 105
NS+L R K + + KNL ++ LE E Q +E L R K
Sbjct: 665 NSELERENRK---------LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
Query: 106 ---KVLDEQIQERE-NSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM----RNMIKHA 157
K+ Q++ +E S+ E+ K EL L A+ K LE + + + + K
Sbjct: 716 ASMKMAQLQLENKELESEKEQLKKGLEL---LKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 158 EMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKL 217
E + + + L+ +QT +Q LE+L + + +L E++ +LE
Sbjct: 773 ENSNKKIQQLESELQDLEMENQT-LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 218 HEEEQERKRMQAKAAELQTGLETNRLIFE--DKATPCVPNARRIKKK---KSKPPEKKSS 272
+ E+E KR++ +A T LE N + +K + I K+ + K EK++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 273 RNYFGAQ-------------PHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSK 319
A +L M K T + N + +LH + S
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH--DEQST 949
Query: 320 ALCNDRVINS---IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSF 376
+++ S L K + + K L S N++L + L+T++ + +
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK- 1008
Query: 377 DHQQLAKLIQESPTVELKD-KLECELEALVGRMEAKANQITKVRKYQA--QLEKQKLEKQ 433
Q +++Q SP + +D K E E + + +++ +V + A Q EKQ L+ Q
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 434 KKELKATKKTLD-------------EERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQL 480
K+L+ L +E+N++ ++ + + + +N QL
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 481 LKDMQSIQNSLQS 493
L S++N +S
Sbjct: 1129 LIQQSSLENENES 1141
Score = 53.9 bits (128), Expect = 3e-07
Identities = 89/450 (19%), Positives = 179/450 (39%), Gaps = 62/450 (13%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
K+L ++ L R+ E +T+E + + ++ + + K NQ L+ ++
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
EN+ ++ L+ +N+ K M+ + LEK + RE Q + +LE
Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDL-MKEKAQLEKTIETLRENSERQ---------IKILE 557
Query: 194 QEYNKLT-TMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPC 252
QE L T+ +L ++ EA++ + E+E K + E T + +++ FE
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE--TSSKLSKIEFE------ 609
Query: 253 VPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLV-- 310
R+IKK+ EK + H+ K + N+++
Sbjct: 610 ---KRQIKKELEHYKEKGERAEELENELHH----------LEKENELLQKKITNLKITCE 656
Query: 311 -LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQD 369
+ ++Q + L + + L K + S + +L ++ ++EE E+ + ++
Sbjct: 657 KIEALEQENSELERE----NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 370 -EFGQMSFDHQQLAKLIQESPTVELKDKLEC---------ELEALVGRMEAKANQITKV- 418
+ M QL ES +LK LE LE ++ + ++ K
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 419 ----RKYQ--------AQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFM 466
+K Q ++E Q L+K +ELK + K L++ + + +KD
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 467 KLRPGEKRRKNLQLLKDMQSIQNSLQSSSL 496
+L KR + +KD +N+++ +L
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Score = 47.4 bits (111), Expect = 3e-05
Identities = 41/170 (24%), Positives = 82/170 (48%), Gaps = 12/170 (7%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKC 140
+ L +E A+ ++ L +E E + L + QE E + E + QE LL+
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE-NMNLLSDARSA 305
Query: 141 NLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLT 200
+ +L+ +R + R LE +VS +ER HD ++++E+L +++ L
Sbjct: 306 RMYRDELDALRE-----KAVRVDKLESEVSRYKERLHDIEFYKARVEEL---KEDNQVLL 357
Query: 201 TMQALAEKKMQELEA---KLHEEEQERKRMQAKAAELQTGLETNRLIFED 247
+ + E +++ A KLHE E+E +++AK +++ + +R E+
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE 407
Score = 42.7 bits (99), Expect = 8e-04
Identities = 86/428 (20%), Positives = 172/428 (40%), Gaps = 54/428 (12%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLS--RETIEYKKVLDEQIQERENSKN-EESKHNQEL 129
LKN+ ++RL ER + E++ LS R+ + + Q S + ++ Q L
Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL 249
Query: 130 TSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQH---DQTHVQSQL 186
+ +L A+ K L ++LE + + E + + L++E + D +
Sbjct: 250 SVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
++LD L ++ ++ + E ++ + +LH+ E + R++ + Q LET ++ E
Sbjct: 310 DELDALREKAVRVDKL----ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML-E 364
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVAN 306
D+ R + K EK++ + + L DM ++
Sbjct: 365 DQL-----EGTRARSDKLHELEKENLQ--------LKAKLHDMEMERDMDRKKIEELMEE 411
Query: 307 VQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQT 366
+ L + ++ S D ++ +Q+S ++ +LS P S G EV +
Sbjct: 412 -NMTLEMAQKQSM----DESLHLGWELEQIS----RTSELSEAPQKSLG-----HEVNEL 457
Query: 367 LQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLE 426
++ ++Q L K ++ EL V +E A++I K+ K +L
Sbjct: 458 TSSRLLKLEMENQSLTKTVE-------------ELRTTVDSVEGNASKILKMEKENQRLS 504
Query: 427 KQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQS 486
K K+E + E+ K++L +N S +K LR E + +++L+
Sbjct: 505 K-KVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR--ENSERQIKILEQENE 561
Query: 487 IQNSLQSS 494
N SS
Sbjct: 562 HLNQTVSS 569
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 67.0 bits (162), Expect = 4e-11
Identities = 97/469 (20%), Positives = 194/469 (41%), Gaps = 73/469 (15%)
Query: 58 TLAYPESNSRAIFSALK-NLQDKIRRLELERIQAEE-SVKTLSRETIEYKKVLDEQIQER 115
TL S+S+ LK +L K +R + + + + ++ +ET+ KK +QIQ+
Sbjct: 491 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT--KQIQDM 548
Query: 116 ENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSL---- 171
K ++ +L L E K N+L+K++E ++ ++ E + +S+ E+ SL
Sbjct: 549 AEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADT 608
Query: 172 ---------------ERER-------QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKK 209
E+ER Q D+ + Q E++D +++ L +L +
Sbjct: 609 TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ-EEIDNYKKDLKDLKEKVSLLQGD 667
Query: 210 MQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEK 269
+ E EA L + ++ + + + + L+T + E K C+ ++KK E
Sbjct: 668 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 727
Query: 270 KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINS 329
++S P + + + S A V +L ++K+ ND+
Sbjct: 728 RAS-------PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK-NDKDKKI 779
Query: 330 IPLAKQVSSRGGK-----------SKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDH 378
L +QV + K KK + + + L++ Q LQD +
Sbjct: 780 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
Query: 379 QQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLE--KQKLEKQKKE 436
++L + ++ES + + ++ L A+ N +V + +E KQ+LE K +
Sbjct: 840 EELEEALRESVQITAEREM-----VLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 894
Query: 437 LKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQ 485
L +T+++L E+ T TN + +RRK+L+ + +M+
Sbjct: 895 LSSTQQSLAEKE--------THLTNLR--------AERRKHLEEVLEMK 927
Score = 56.6 bits (135), Expect = 5e-08
Identities = 81/473 (17%), Positives = 197/473 (41%), Gaps = 58/473 (12%)
Query: 46 LNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYK 105
L+++ R K Y S+S+ + + ++ L++++ E + + ++ L E + K
Sbjct: 414 LSTEEREEEMKQMEVY-RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
Query: 106 K----------VLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK 155
+ L +++ N ++ +H + L L A E + +L+ +++ +R ++
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532
Query: 156 HAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEA 215
E ++ + E+ + + LD+ E++ N L +KK++ L+
Sbjct: 533 EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL-------QKKIENLQE 585
Query: 216 KLHEEEQERKRMQAKAAELQ---TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSS 272
+L ++E++ ++ + LQ T +T E+ R+K+++ + +K
Sbjct: 586 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 645
Query: 273 RNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCN-----DRVI 327
+Y+ L D+ + S ++ + L +K+H+ +L + D +
Sbjct: 646 E-----IDNYKKDLKDLK----EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL 696
Query: 328 NSIPLA------------KQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMS 375
++ +A Q+ + + +P S+ I + L + +DE +
Sbjct: 697 KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI-QHLEREITRYKDESSKAQ 755
Query: 376 FDHQQLAKLIQESPTVEL-KDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQK 434
+ +L ++++E + KDK ELE V K + K++ Q+EK+K +
Sbjct: 756 AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL----KHKEQVEKKKSAQML 811
Query: 435 KELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSI 487
+E + + L++ S + + KKD E R+++Q+ + + +
Sbjct: 812 EEARRREDNLND-----SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 859
Score = 45.4 bits (106), Expect = 1e-04
Identities = 90/465 (19%), Positives = 179/465 (38%), Gaps = 83/465 (17%)
Query: 49 DLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRET-IEYKKV 107
+LR K TL + +I L+ LQ K + E + + E + + +
Sbjct: 292 ELRIETQKQTL---NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
Query: 108 LDEQIQERENSKNEESKH----NQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTS 163
L EQ +E+ENS E H N +++ A + + + ++ M ++ E E
Sbjct: 349 LLEQ-KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLE-EEIQ 406
Query: 164 VLEKQVSLERERQHDQ--------THVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEA 215
+L+ +L E + ++ +H + K++ L++E + +KK L+A
Sbjct: 407 MLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQA 466
Query: 216 KLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNY 275
++ + +QE R + LQT LET F D + K+ E+++
Sbjct: 467 EIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI-----EVLKESLTAKEQRA---- 517
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
A++ L L + + + N + +A++
Sbjct: 518 --------------------------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE 551
Query: 336 VSSRGGK----SKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTV 391
++ G+ L V N + +++ + + L+D+ QMS +++ L ++
Sbjct: 552 KGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT 611
Query: 392 ELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSS 451
+ AL EA A + + + + Q ++ + EKQ +E+ KK L +
Sbjct: 612 D---------TALTTLEEALAEKERTIERLKEQRDRDEREKQ-EEIDNYKKDLKD----- 656
Query: 452 SRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSL 496
K+ + L G+ K LL D++ +SL SS L
Sbjct: 657 ----------LKEKVSLLQGDLSEKEASLL-DLKEHASSLASSGL 690
Score = 43.5 bits (101), Expect = 4e-04
Identities = 80/393 (20%), Positives = 166/393 (42%), Gaps = 56/393 (14%)
Query: 74 KNLQDKIRRLELERI--QAEESVKTLSRET-IEYK-----------KVLDEQIQERENSK 119
K ++ + R E+ R A +S KT + +T IE K + L+E+IQ +++
Sbjct: 353 KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
Query: 120 NEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQ 179
++ +E Q+ + ++ ++E ++ + E + + +K L+ E +
Sbjct: 413 ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
Query: 180 THVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLE 239
+ + +L L+ + LT + +++ ++ L+ L +EQ +AA LQT ++
Sbjct: 473 QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ-------RAAILQTEVD 525
Query: 240 TNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSP 299
RL E+K T + KK+K + + G Q L DM V + +
Sbjct: 526 ALRLRLEEKET--------MLNKKTKQIQDMAEEK--GTQAGEIHDLKDMLDVKERKVNV 575
Query: 300 SHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSV----TPPSSNG 355
+ N+Q L KQ+SS + K L T +
Sbjct: 576 LQKKIENLQEQLR------------------DKEKQMSSLKERVKSLQADTTNTDTALTT 617
Query: 356 INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI 415
+ E L+E +T++ Q D ++ + I ++ +LKD L+ ++ L G + K +
Sbjct: 618 LEEALAEKERTIERLKEQRDRDEREKQEEI-DNYKKDLKD-LKEKVSLLQGDLSEKEASL 675
Query: 416 TKVRKYQAQLEKQKLEKQKKELKATKKTLDEER 448
++++ + L L+K + LK + L++++
Sbjct: 676 LDLKEHASSLASSGLKKDSR-LKTLEIALEQKK 707
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 67.0 bits (162), Expect = 4e-11
Identities = 97/469 (20%), Positives = 194/469 (41%), Gaps = 73/469 (15%)
Query: 58 TLAYPESNSRAIFSALK-NLQDKIRRLELERIQAEE-SVKTLSRETIEYKKVLDEQIQER 115
TL S+S+ LK +L K +R + + + + ++ +ET+ KK +QIQ+
Sbjct: 463 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT--KQIQDM 520
Query: 116 ENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSL---- 171
K ++ +L L E K N+L+K++E ++ ++ E + +S+ E+ SL
Sbjct: 521 AEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADT 580
Query: 172 ---------------ERER-------QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKK 209
E+ER Q D+ + Q E++D +++ L +L +
Sbjct: 581 TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ-EEIDNYKKDLKDLKEKVSLLQGD 639
Query: 210 MQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEK 269
+ E EA L + ++ + + + + L+T + E K C+ ++KK E
Sbjct: 640 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 699
Query: 270 KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINS 329
++S P + + + S A V +L ++K+ ND+
Sbjct: 700 RAS-------PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK-NDKDKKI 751
Query: 330 IPLAKQVSSRGGK-----------SKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDH 378
L +QV + K KK + + + L++ Q LQD +
Sbjct: 752 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 811
Query: 379 QQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLE--KQKLEKQKKE 436
++L + ++ES + + ++ L A+ N +V + +E KQ+LE K +
Sbjct: 812 EELEEALRESVQITAEREM-----VLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 866
Query: 437 LKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQ 485
L +T+++L E+ T TN + +RRK+L+ + +M+
Sbjct: 867 LSSTQQSLAEKE--------THLTNLR--------AERRKHLEEVLEMK 899
Score = 54.7 bits (130), Expect = 2e-07
Identities = 74/412 (17%), Positives = 172/412 (41%), Gaps = 48/412 (11%)
Query: 97 LSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKH 156
LSR+ E L +++ N ++ +H + L L A E + +L+ +++ +R ++
Sbjct: 447 LSRKDTELL-ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE 505
Query: 157 AEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAK 216
E ++ + E+ + + LD+ E++ N L +KK++ L+ +
Sbjct: 506 KETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL-------QKKIENLQEQ 558
Query: 217 LHEEEQERKRMQAKAAELQ---TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSR 273
L ++E++ ++ + LQ T +T E+ R+K+++ + +K
Sbjct: 559 LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 618
Query: 274 NYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCN-----DRVIN 328
+Y+ L D+ + S ++ + L +K+H+ +L + D +
Sbjct: 619 -----IDNYKKDLKDLK----EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
Query: 329 SIPLA------------KQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSF 376
++ +A Q+ + + +P S+ I + L + +DE +
Sbjct: 670 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI-QHLEREITRYKDESSKAQA 728
Query: 377 DHQQLAKLIQESPTVEL-KDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKK 435
+ +L ++++E + KDK ELE V K + K++ Q+EK+K + +
Sbjct: 729 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL----KHKEQVEKKKSAQMLE 784
Query: 436 ELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSI 487
E + + L++ S + + KKD E R+++Q+ + + +
Sbjct: 785 EARRREDNLND-----SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 831
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 66.2 bits (160), Expect = 6e-11
Identities = 93/431 (21%), Positives = 176/431 (40%), Gaps = 58/431 (13%)
Query: 75 NLQDKIRRLELERIQAEESVKTLSR---ETIEYKKVLDEQIQERENSKNEESKHNQELTS 131
NL+ + LE + + VK L + E+ +K LD Q+QE +E + EL
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280
Query: 132 QLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDL 191
K + L+ +L+ + +++ AE + + SLE + Q Q +Q +
Sbjct: 1281 -------KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR---- 1329
Query: 192 LEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL-ETNRLIFEDKAT 250
Q+ N + ++ L E+K L+ + EEE+ RK ++ + LQ+ L +T + + +D T
Sbjct: 1330 --QKLNLSSRIRQLEEEK-NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT 1386
Query: 251 PCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLV 310
+ + KKK K E S R L + K
Sbjct: 1387 --IESLEEAKKKLLKDAEALSQR------------LEEKALAYDK--------------- 1417
Query: 311 LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDE 370
L K + +D ++ + S+ K KK I+ +E + E
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477
Query: 371 FGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQK- 429
+ LA+ ++E+ +E K++ E + + L ME + V K +LEK K
Sbjct: 1478 AREKETKALSLARALEEA--LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 430 -LEKQKKELKATKKTLDEERNSSSRSGITGTTN----KKDF---MKLRPGEKRRKNLQLL 481
LE+Q +E++ + L++E ++ + + N K F ++ R + K L+
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 482 KDMQSIQNSLQ 492
K ++ ++ L+
Sbjct: 1596 KQVRELEAELE 1606
Score = 60.8 bits (146), Expect = 3e-09
Identities = 92/456 (20%), Positives = 197/456 (43%), Gaps = 43/456 (9%)
Query: 81 RRLELERIQAEESVKTLSRET----------IEYKKVLDEQIQERENSKNEESKHNQELT 130
++L+LE++ AE +K + E I+ KK+++++I E + EE + + L
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 131 SQLLAAENKCNLLEKQL---EYMRNMIKHAEME---RTSVLEKQVSLERERQHDQTHVQS 184
E + LE++L E R ++ A+ + T+ L+ Q++ E + Q D+ +Q
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA-ELQAQIDELKLQL 1085
Query: 185 QLEKLDLL-------EQEYNKLTTMQALAEKKMQ--ELEAKLHEEEQERKRMQAKAAELQ 235
++ +L ++ +K ++ + E + Q EL+ E+ R + + + +L
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 236 TGLETNRLIFEDKA-TPCVPNARRIKKKKSKPPEKKS----SRNYFGAQPHYRLCLGDMP 290
LE + ED T R K+++ KK+ ++N+ R
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATAL 1205
Query: 291 FVAGKSTSPSHAVVANVQLVLHLMKQHSKAL-CNDRVINSIPLAKQVSSR--GGKSKKLS 347
+ + AN++ ++ +K L C +V+ + + + + ++L
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 348 VTPPSSNGINEELSEVLQTLQDEFGQMS--FDHQQLAKLIQESPTVELKDKLECELEALV 405
+ + EL+E LQ+E +S + + + L+ +L+ E L
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 406 GRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNK--K 463
K N +++R Q + EK L++Q++E + +K L E++ + +S + T K
Sbjct: 1326 EETRQKLNLSSRIR--QLEEEKNSLQEQQEEEEEARKNL-EKQVLALQSQLADTKKKVDD 1382
Query: 464 DFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWD 499
D + E+ +K +LLKD +++ L+ +L +D
Sbjct: 1383 DLGTIESLEEAKK--KLLKDAEALSQRLEEKALAYD 1416
Score = 57.0 bits (136), Expect = 4e-08
Identities = 85/444 (19%), Positives = 178/444 (40%), Gaps = 58/444 (13%)
Query: 67 RAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHN 126
R + + + LQ+ + R +AE+ + LS E K L++ + + +K
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 127 QELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEK----QVSLERERQHDQTHV 182
QE+ A E + E Q++ MR A E + LE+ + +LE+ +Q +T
Sbjct: 1174 QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Query: 183 QSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNR 242
+ ++ +L+Q + + + ++QEL AK+ E ++ R + KA++LQ L+
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Query: 243 LIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHA 302
+ E+ + A K S + + ++ + +L
Sbjct: 1294 TLLEEAEKKGIKFA---KDAASLESQLQDTQELLQEETRQKL------------------ 1332
Query: 303 VVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSE 362
N+ + +++ NS+ ++ K+ + V + +L++
Sbjct: 1333 ---NLSSRIRQLEEEK---------NSLQEQQEEEEEARKNLEKQVL-----ALQSQLAD 1375
Query: 363 VLQTLQDEFGQMSFDHQQLAKLIQE----SPTVELKDKLECELEALVGRMEAKANQITKV 418
+ + D+ G + + KL+++ S +E K +LE R++ + + +T
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 419 RKYQAQLEKQKLEKQKK--ELKATKKTLD----EERNSSSRSGITGTTNKKDFMKL---- 468
+Q Q+ +KQKK +L A +K++ EER+ + T +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 469 --RPGEKRRKNLQLLKDMQSIQNS 490
E R+N QL DM+ + +S
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSS 1519
Score = 56.2 bits (134), Expect = 7e-08
Identities = 97/478 (20%), Positives = 191/478 (39%), Gaps = 72/478 (15%)
Query: 69 IFSALKNLQDKIRRLELERIQAEESVKTLSRET----------------IEYKKVLDEQI 112
+F+ +K L R+ E + + EE +K ++T +E K +L EQ+
Sbjct: 837 VFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896
Query: 113 Q-------ERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAE---MERT 162
Q E E + + QEL L E++ E++ + ++N K + +
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 163 SVLEKQVSLERERQHDQTHVQSQLEKLD----LLEQEYNKLTTMQALAEKKMQELEAKLH 218
L+++ ++ Q ++ +++++K++ LLE + +K + L E ++ E ++L
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 219 EEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGA 278
EEE++ K + A+++ E E+ R K++K++ +K+ R G
Sbjct: 1017 EEEEKAKNL----AKIRNKQEVMISDLEE---------RLKKEEKTRQELEKAKRKLDGE 1063
Query: 279 QPHYRLCLGDMPF--------VAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSI 330
+ + ++ +A K A+ LH K ++ + +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH--KNNALKVVRELQAQIA 1121
Query: 331 PLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPT 390
L + S K ++EEL + L+D + QQ + +E
Sbjct: 1122 ELQEDFESEKASRNK---AEKQKRDLSEELEALKTELEDTLDTTA--AQQELRTKREQEV 1176
Query: 391 VELKDKLECEL---EALVGRM--------EAKANQITKVRKYQAQLEKQK--LEKQKKEL 437
ELK LE E EA + M E + Q+ + ++++A LEK K LE KEL
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 438 KATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSS 495
K L + + S ++ + + E R ++L + +QN L + S
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQE-LHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Score = 53.5 bits (127), Expect = 4e-07
Identities = 82/392 (20%), Positives = 158/392 (40%), Gaps = 53/392 (13%)
Query: 82 RLELERIQAEESVKTLSR---ETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAEN 138
R E E + E +L+R E +E K+ + Q ++ + ++ + E
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 139 KCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNK 198
LE+Q+E MR ++ E E + + ++ LE Q + + L+ D +E +
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592
Query: 199 LTTMQALAEKKMQELEAKLHEEEQER-------KRMQAKAAELQTGLETNRLIFEDKATP 251
L K+++ELEA+L +E ++R K+M+ +L+ +E ++
Sbjct: 1593 LLI------KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 252 CVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVL 311
++K + + E ++SR+ AQ + K A + +Q L
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKE----------SEKKLKSLEAEILQLQEEL 1696
Query: 312 HLMKQHSKALCNDRVINSIPLAKQVS-SRGGKSKKLSVTPPSSNGINEELSEVLQTLQDE 370
++ + +R LA +++ S GKS L + ++++ + L++E
Sbjct: 1697 ASSERARRHAEQERD----ELADEITNSASGKSALLD----EKRRLEARIAQLEEELEEE 1748
Query: 371 FGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKL 430
M + + K T D L EL A E A Q ++ +Q+L
Sbjct: 1749 QSNMELLNDRFRK------TTLQVDTLNAELAA-----ERSAAQ-------KSDNARQQL 1790
Query: 431 EKQKKELKATKKTLDEERNSSSRSGITGTTNK 462
E+Q KELKA + L+ S ++ I+ K
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAK 1822
Score = 40.4 bits (93), Expect = 0.004
Identities = 78/427 (18%), Positives = 170/427 (39%), Gaps = 59/427 (13%)
Query: 73 LKNLQDKIRRLELE----RIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQE 128
L+ +D RLE+ + Q E ++T + E K++L +Q++E E +E K
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ--- 1611
Query: 129 LTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEK 188
+ LA +K +E L+ + I+ A R V+++ L+ + + Q ++
Sbjct: 1612 ---RALAVASK-KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 189 LDLLEQEYNKLTTMQALAEKKMQELEA---KLHEEEQERKRMQAKAAELQTGLETNRLIF 245
D ++ +EKK++ LEA +L EE +R + A + + L
Sbjct: 1668 RD-------EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 246 EDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVA 305
+ + RR++ + ++ E+ +M + + + V
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQ------------SNMELLNDRFRKTTLQVDT 1768
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
L L + S A +D A+Q R K K + + + +
Sbjct: 1769 ---LNAELAAERSAAQKSDN-------ARQQLERQNKELKAKL-QELEGAVKSKFKATIS 1817
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
L+ + GQ+ +Q AK + + +L + E +L+ + ++E + + A
Sbjct: 1818 ALEAKIGQLEEQLEQEAK--ERAAANKLVRRTEKKLKEIFMQVEDE--------RRHADQ 1867
Query: 426 EKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQ 485
K+++EK +K K+ L+E ++R+ + +++ + N L +++
Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL-----DDATEANEGLSREVS 1922
Query: 486 SIQNSLQ 492
+++N L+
Sbjct: 1923 TLKNRLR 1929
Score = 38.1 bits (87), Expect = 0.019
Identities = 67/406 (16%), Positives = 151/406 (37%), Gaps = 45/406 (11%)
Query: 91 EESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNL---LEKQL 147
E+ K + E K + +ER+ ++ E + + S A E E+Q
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 148 EYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAE 207
+ +R ++ + V + LE+ ++ + V+ +L+ LE E + E
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566
Query: 208 KKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPP 267
MQ ++A+ +LQT E N E+K + R ++ +
Sbjct: 1567 VNMQAMKAQFER-------------DLQTRDEQN----EEKKRLLIKQVRELEAELE--D 1607
Query: 268 EKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVI 327
E+K ++ + L D+ + V+ ++ + MK + + L
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL------ 1661
Query: 328 NSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQE 387
+R + + + + S + +E+LQ LQ+E + A+ E
Sbjct: 1662 --------EEARASRDEIFAQSKESEKKLKSLEAEILQ-LQEELAS-----SERARRHAE 1707
Query: 388 SPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEE 447
EL D++ ++ K ++ + + +LE+++ + + K TL +
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 448 RNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQS 493
++ + K D + + R+N +L +Q ++ +++S
Sbjct: 1768 TLNAELAAERSAAQKSDNAR---QQLERQNKELKAKLQELEGAVKS 1810
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 65.1 bits (157), Expect = 1e-10
Identities = 97/462 (20%), Positives = 193/462 (41%), Gaps = 57/462 (12%)
Query: 55 SKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRET---IEYKKVLDEQ 111
+K LA E+ + + + +L + L+L+ E++ I+ K +L+ +
Sbjct: 863 TKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAK 922
Query: 112 IQERENSKNEESKHNQELTSQLLAAENKCNLL--------------EKQLEYMRNMIKHA 157
++E EE + N EL ++ E+KC+ L EK+ N +K+
Sbjct: 923 VKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNL 982
Query: 158 EMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKL 217
E T++ E L +E++ Q Q L+ L + E + N L + A E++ +LE L
Sbjct: 983 SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 218 HEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFG 277
+E++ R ++ +L+ L+ ++ D ++KKK+ + + ++ +
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID--D 1100
Query: 278 AQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVS 337
Q H + + +Q + +++ +A R + KQ S
Sbjct: 1101 EQVH---------------SLQFQKKIKELQARIEELEEEIEAEHTLRA----KIEKQRS 1141
Query: 338 SRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKL 397
+ +++S ++G E+ + + EF +M D ++ A L E+ L+ K
Sbjct: 1142 DLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE-ATLQHEATAATLRKKQ 1200
Query: 398 ECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTL--DEERNSSSRSG 455
+ L QI +++ KQKLEK+K ELK + + E S S+S
Sbjct: 1201 ADSVAEL-------GEQIDNLQRV-----KQKLEKEKSELKMEIDDMASNIEALSKSKSN 1248
Query: 456 ITGT--TNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSS 495
I T T + F +++ K + QL+ D+ + LQ+ +
Sbjct: 1249 IERTCRTVEDQFSEIK--AKDEQQTQLIHDLNMQKARLQTQN 1288
Score = 60.1 bits (144), Expect = 5e-09
Identities = 76/352 (21%), Positives = 146/352 (41%), Gaps = 39/352 (11%)
Query: 136 AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQE 195
AE + +++ E + + +E R + EK VSL +E+ Q VQS+ E L E+
Sbjct: 849 AEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER 908
Query: 196 YNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ-----------------TGL 238
L + L E K++EL +L EEE+ + AK L+ T +
Sbjct: 909 CEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKV 968
Query: 239 ETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTS 298
E + E+K +++ SK ++K S Q ++ L D+ K
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKS-----LQEAHQQTLDDLQVEEDK--- 1020
Query: 299 PSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSK-KLSVTPPSSNGIN 357
V +++ L +Q D + S+ K++ + ++K KL S
Sbjct: 1021 ----VNGLIKINAKLEQQ------TDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESI 1070
Query: 358 EELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITK 417
+L Q ++++ + F+ QL I + L + + +++ L R+E +I
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL--QFQKKIKELQARIEELEEEIEA 1128
Query: 418 VRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLR 469
+A++EKQ+ + +EL+ + L+E ++S + +F K+R
Sbjct: 1129 EHTLRAKIEKQRSD-LARELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179
Score = 58.9 bits (141), Expect = 1e-08
Identities = 83/429 (19%), Positives = 177/429 (41%), Gaps = 83/429 (19%)
Query: 92 ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMR 151
E ++L + + K+ L +Q++E + EE+K + L ++ + C+LL +Q E
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE--- 1352
Query: 152 NMIKHAEMERTSVLEKQVSLERER--QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKK 209
E E + L++ +S Q + +++ + LE+ KL AE+
Sbjct: 1353 -----EEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 210 MQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEK 269
+ +K E+ ++R+Q + +L LE + T C
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSH-------TACA-------------TLD 1447
Query: 270 KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINS 329
K RN+ ++ L + Q L ++ S++L S
Sbjct: 1448 KKQRNFDKVLAEWKQKLDES------------------QAELEAAQKESRSL-------S 1482
Query: 330 IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESP 389
L K ++ +L + + EE+S++ + + E G+ + ++ KL+++
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA-ETGKNLQEAEKTKKLVEQE- 1540
Query: 390 TVELKDKLECELEALVGRMEAKANQITKVR----KYQAQLEKQKLEK----------QKK 435
K L+ LE + G +E + ++I +V+ + +++L+++ +EK ++
Sbjct: 1541 ----KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQR 1596
Query: 436 ELKATKKTLDEE---RNSSSR--SGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNS 490
+A + LD E RN + R + G N+ M+++ G R+ + K ++++Q
Sbjct: 1597 AAEALQSVLDAEIRSRNDALRLKKKMEGDLNE---MEIQLGHSNRQMAETQKHLRTVQGQ 1653
Query: 491 LQSSSLCWD 499
L+ S L D
Sbjct: 1654 LKDSQLHLD 1662
Score = 57.8 bits (138), Expect = 2e-08
Identities = 98/459 (21%), Positives = 192/459 (41%), Gaps = 74/459 (16%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQ 132
+ +L+ + ++E E+ E VK LS E L+E I + K + +Q+
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMT----ALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 133 LLAAENKCN-------LLEKQLEYMRNMIKH-----AEMERTS-VLEKQVSLERER---- 175
L E+K N LE+Q + + ++ A++ER LE + + +E
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDL 1073
Query: 176 QHDQTHVQSQLEKLDL-LEQEYNKLTTMQALA---EKKMQELEAKLHEEEQE-------R 224
++D+ ++ +L+K + L Q K+ Q + +KK++EL+A++ E E+E R
Sbjct: 1074 ENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR 1133
Query: 225 KRMQAKAAELQTGLE--TNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHY 282
+++ + ++L LE + RL AT +A+ KK + +K R+ A +
Sbjct: 1134 AKIEKQRSDLARELEEISERLEEASGAT----SAQIEMNKKREAEFQKMRRDLEEATLQH 1189
Query: 283 RLCLGDMPFVAGKSTSPSHAVVANVQLV---LHLMKQHSKALCNDRVINSIPLAKQVSSR 339
+ S + + N+Q V L K K +D N L+K S+
Sbjct: 1190 EATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN- 1248
Query: 340 GGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLEC 399
+ +T++D+F ++ +Q +LI + K +L+
Sbjct: 1249 --------------------IERTCRTVEDQFSEIKAKDEQQTQLIHDLNM--QKARLQT 1286
Query: 400 ELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGT 459
+ L R+E K + I+++ K KQ L +Q +EL K+ ++EE + +
Sbjct: 1287 QNGELSHRVEEKESLISQLTK-----SKQALTQQLEEL---KRQMEEETKAKNAMAHALQ 1338
Query: 460 TNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCW 498
+++ D LR E+ + + ++Q + S W
Sbjct: 1339 SSRHDCDLLR--EQYEEEQEAKAELQRALSKANSEVAQW 1375
Score = 53.5 bits (127), Expect = 4e-07
Identities = 91/435 (20%), Positives = 182/435 (41%), Gaps = 47/435 (10%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNE---ESKHNQELT 130
+ LQ ++ L + ++ + TL ++ + KVL E Q+ + S+ E K ++ L+
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLS 1482
Query: 131 SQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLD 190
++L N + QLE +R K+ + E + + E+ + Q + +
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE-------KTKK 1535
Query: 191 LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKAT 250
L+EQE + L + ++E+E L EE + R+Q + +++++ L+ + +++
Sbjct: 1536 LVEQEKSDL-------QVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIE 1588
Query: 251 PCVPNARRIKK--KKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQ 308
N++R + + E +S + + L +M G S +++
Sbjct: 1589 QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLR 1648
Query: 309 LVLHLMKQHSKALCNDRVINSIPLAKQ---VSSRGG----KSKKLSVTPPSSNGINEELS 361
V +K S+ +D + ++ L +Q V R G + +++ V + LS
Sbjct: 1649 TVQGQLKD-SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER-TRRLS 1706
Query: 362 EVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAK------ANQI 415
E Q L D ++ H Q LI +E D +C+ E E++ I
Sbjct: 1707 E--QELLDASDRVQLLHSQNTSLINTKKKLE-ADIAQCQAEVENSIQESRNAEEKAKKAI 1763
Query: 416 TKVRKYQAQLEKQK-----LEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRP 470
T +L+K++ LE+ KK L+ T K L + + + + G KK KL
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG--GKKQIQKL-- 1819
Query: 471 GEKRRKNLQLLKDMQ 485
E R + L+ D++
Sbjct: 1820 -ENRVRELENELDVE 1833
Score = 37.0 bits (84), Expect = 0.042
Identities = 45/228 (19%), Positives = 97/228 (42%), Gaps = 21/228 (9%)
Query: 56 KPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQER 115
K L E R L + D+++ L + + K L + + + ++ IQE
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE- 1751
Query: 116 ENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERER 175
S+N E K + +T + AE L+K+ + ++ + + +V + Q L+
Sbjct: 1752 --SRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1805
Query: 176 QHDQTHVQSQLEKLDLLEQEY-NKLTTMQALA----------EKKMQELEAKLHEEEQER 224
Q + Q++KL+ +E N+L Q E+K++E+ + E+ +
Sbjct: 1806 QLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNI 1865
Query: 225 KRMQAKAAELQTGLETNRL---IFEDKATPCVPNARRIKKKKSKPPEK 269
R+Q +LQ +++ + E++A + RR++ + + E+
Sbjct: 1866 LRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAER 1913
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 64.7 bits (156), Expect = 2e-10
Identities = 97/432 (22%), Positives = 175/432 (40%), Gaps = 51/432 (11%)
Query: 79 KIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAEN 138
K+R +L ++TL + + K L EQ+Q E + LT++ E
Sbjct: 856 KVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 139 KCNLLEKQLEYMRNMIKHAEMERTSV----------LEKQVSLERERQHDQTHVQSQLEK 188
C+ LE ++E +H + E+ + LE++ S ++ Q ++ +++L+K
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 189 LD----LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK---RMQAKAAELQTGLETN 241
L+ +LE + KL + L E ++ E L EEE++ K +++ K + T LE
Sbjct: 976 LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLE-E 1034
Query: 242 RLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSH 301
RL E+K +R + +K++ + S + + + ++ K
Sbjct: 1035 RLRREEK--------QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 302 AVVANVQLVLHLMKQHSKALCNDRVINS--IPLAKQVSSRGGKSKKLSVTPPSSNGINEE 359
A +A V+ Q + AL R + S L + + S K + EE
Sbjct: 1087 AALARVE---EEAAQKNMALKKIRELESQISELQEDLESERASRNK---AEKQKRDLGEE 1140
Query: 360 LSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECEL---EALVGRMEAKANQIT 416
L + L+D + + +K QE LK LE E EA + M K +Q
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNI--LKKTLEEEAKTHEAQIQEMRQKHSQ-- 1196
Query: 417 KVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRK 476
V + QLE+ K + K L+ K+TL+ ER N+ + G+ K
Sbjct: 1197 AVEELAEQLEQTK--RVKANLEKAKQTLENERGE--------LANEVKVLLQGKGDSEHK 1246
Query: 477 NLQLLKDMQSIQ 488
++ +Q +Q
Sbjct: 1247 RKKVEAQLQELQ 1258
Score = 60.5 bits (145), Expect = 4e-09
Identities = 96/449 (21%), Positives = 178/449 (39%), Gaps = 60/449 (13%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
K + +I+ + + QA E + +T K L++ Q EN + E + + L
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQH---------------- 177
+E+K +E QL+ ++ E RT + +K L+ E +
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 1300
Query: 178 -DQTHVQSQLEKLDLLEQEYNK----LTTMQALAEKKMQELEAKLHEEEQERKRMQAKAA 232
D + ++SQL+ L QE N+ L+T E + +L EEE+ + ++ + A
Sbjct: 1301 KDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360
Query: 233 ELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFV 292
L + + ED + C+ A +K+K K E S R+ + +L
Sbjct: 1361 TLHAQVADMKKKMED-SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL-------- 1411
Query: 293 AGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPS 352
+ + L++ L Q A CN L K K KK
Sbjct: 1412 ---EKTKTRLQQELDDLLVDLDHQRQSA-CN--------LEK-------KQKKFDQLLAE 1452
Query: 353 SNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKA 412
I+ + +E + E + LA+ ++E+ +E K +LE + ME
Sbjct: 1453 EKTISAKYAEERDRAEAEAREKETKALSLARALEEA--MEQKAELERLNKQFRTEMEDLM 1510
Query: 413 NQITKVRKYQAQLEKQK--LEKQKKELKATKKTLDEERNSSSRSGITGTTN----KKDF- 465
+ V K +LEK K LE+Q +E+K + L++E ++ + + N K F
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 466 --MKLRPGEKRRKNLQLLKDMQSIQNSLQ 492
++ R + K QL++ ++ ++ L+
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELE 1599
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/402 (21%), Positives = 157/402 (39%), Gaps = 71/402 (17%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKC 140
R+ +R Q ++K L R Y K+ + Q + +++ + E
Sbjct: 796 RKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELV 855
Query: 141 NLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLT 200
+ EKQL AE T + Q L E+ Q +Q++ E E+ +LT
Sbjct: 856 KVREKQLA--------AENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLT 907
Query: 201 TMQALAEKKMQELEAKLHEEEQ-------ERKRMQAKAAELQTGLETNRLIFEDKATPCV 253
+ E+ +LEA++ EEE+ E+K+MQ EL+ LE + V
Sbjct: 908 AKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967
Query: 254 PNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHL 313
++KK + + ++ L D K +A L
Sbjct: 968 TTEAKLKKLEEE-----------------QIILEDQNCKLAKEKKLLEDRIAEFTTNLTE 1010
Query: 314 MKQHSKALC---NDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDE 370
++ SK+L N L +++ + ++L T G + +LS+ + LQ +
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 371 FGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQ----ITKVRKYQAQL- 425
++ QLA K E EL+A + R+E +A Q + K+R+ ++Q+
Sbjct: 1071 IAELK---MQLA-------------KKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114
Query: 426 -----------EKQKLEKQKK----ELKATKKTLDEERNSSS 452
+ K EKQK+ EL+A K L++ +S++
Sbjct: 1115 ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156
Score = 48.9 bits (115), Expect = 1e-05
Identities = 83/430 (19%), Positives = 176/430 (40%), Gaps = 47/430 (10%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
K+L+ +R E + ++ KT +R E +L + +R+++ N E K Q+ QL
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK--QKKFDQL 1449
Query: 134 LAAENKCNLL------EKQLEYMRNMIKHAEMERT--SVLEKQVSLERERQHDQTHVQSQ 185
LA E + + E K + R +E++ LER + +T ++
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 186 LEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIF 245
+ D + + ++L + E++++E++ +L E E E + + L+ L+ + F
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF 1569
Query: 246 E-----------DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAG 294
E +K V R ++ + E+K A+ + L D+
Sbjct: 1570 ERDLQGRDEQSEEKKKQLVRQVREMEAELED--ERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 295 KSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLA------KQVSSRGGK----SK 344
+ + ++ + MK + L + R LA K++ S + +
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 345 KLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECE---L 401
+L+ + +E E+ + + G+ + ++ +L E+ +L+++LE E
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL--EARIAQLEEELEEEQGNT 1745
Query: 402 EALVGRMEAKANQITKV-------RKYQAQLE--KQKLEKQKKELKATKKTLDEERNSSS 452
E + R++ QI ++ R + + E +Q+LE+Q KELK + ++ S
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805
Query: 453 RSGITGTTNK 462
++ IT K
Sbjct: 1806 KASITALEAK 1815
Score = 45.1 bits (105), Expect = 2e-04
Identities = 81/436 (18%), Positives = 167/436 (38%), Gaps = 71/436 (16%)
Query: 67 RAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHN 126
R + S + LQ+ + R +AE+ + L E K L++ + + SK
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 127 QELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEK-----------QVSLERER 175
QE+ E + E Q++ MR A E LE+ + +LE ER
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 176 -----------------QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQ----ELE 214
+H + V++QL++L + E ++ T A K+Q +
Sbjct: 1227 GELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT 1286
Query: 215 AKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRN 274
L + + + ++ + L++ L+ + + +++ + + ++K+ + EK S R
Sbjct: 1287 GLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED---EKNSFRE 1343
Query: 275 YFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAK 334
+ + L K + HA VA+++ + + + + A+
Sbjct: 1344 QLEEEEEAKHNL-------EKQIATLHAQVADMKKKM------------EDSVGCLETAE 1384
Query: 335 QVSSRGGKS-KKLSVTPPSSNGINEELSEVLQTLQDEFGQM--SFDHQQLA--------- 382
+V + K + LS ++L + LQ E + DHQ+ +
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 383 ---KLIQESPTVELKDKLECE-LEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELK 438
+L+ E T+ K E + EA E KA + + + +A +K +LE+ K+ +
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE-EAMEQKAELERLNKQFR 1503
Query: 439 ATKKTLDEERNSSSRS 454
+ L ++ +S
Sbjct: 1504 TEMEDLMSSKDDVGKS 1519
Score = 39.3 bits (90), Expect = 0.008
Identities = 47/192 (24%), Positives = 82/192 (42%), Gaps = 24/192 (12%)
Query: 73 LKNLQDKIR-----RLELE------RIQAEESVKTLSRETIEYKKVLDEQIQERENSKNE 121
L+ L+D+++ +L LE + Q E ++ ++ E KK L Q++E E +
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 122 ESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERE-----RQ 176
E K S +AA K LE L+ + I A R +++ L+ + R+
Sbjct: 1601 ERKQR----SMAVAARKK---LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 177 HDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQT 236
D T S+ E L ++ KL +M+A + +EL A + Q ++ A E+
Sbjct: 1654 LDDTRA-SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 237 GLETNRLIFEDK 248
L E+K
Sbjct: 1713 SSGKGALALEEK 1724
Score = 38.9 bits (89), Expect = 0.011
Identities = 60/343 (17%), Positives = 140/343 (40%), Gaps = 14/343 (4%)
Query: 74 KNLQDKIRRLE--LERIQAEESVKTLSRETIEYK-KVLDEQIQERENSKNEESKHNQELT 130
K L ++R +E LE + + S+ +R+ +E K L+ I +++E K ++L
Sbjct: 1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 131 SQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLD 190
+Q+ + + E + K E + S+ + + L+ E + + ++ D
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704
Query: 191 LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKAT 250
L E + ALA ++ + LEA++ + E+E + Q + L+ L + T
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764
Query: 251 PCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLV 310
N R +K++ ++ R + + G + S + A +A ++
Sbjct: 1765 DL--NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 311 LHLMKQHSKALC-----NDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
L + +A C ++ + + L R + K S+ ++L L+
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR--LKQLKRQLE 1880
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRM 408
++E + + ++L + ++++ E D + E+ +L ++
Sbjct: 1881 EAEEEAQRANASRRKLQRELEDA--TETADAMNREVSSLKNKL 1921
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 64.7 bits (156), Expect = 2e-10
Identities = 95/453 (20%), Positives = 189/453 (41%), Gaps = 40/453 (8%)
Query: 73 LKNLQDKIRRLELER--IQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELT 130
LK +Q + + E E +A + K E+IE K E ++E E EE Q++
Sbjct: 694 LKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAK--SEAMKEMEKKLLEERTLKQKVE 751
Query: 131 SQLLAAENKCNLLEKQLEY----MRNMIKHAEMERTSVLEKQVSLERERQH---DQTHVQ 183
+ LL AE +C+LL+ L+ + ++K ++ V + +E+E Q Q ++
Sbjct: 752 NLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLK 811
Query: 184 SQLEKLDLLE-------QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQT 236
Q ++++ L+ QE N L M+ EK+ EL + + + + K +Q + Q
Sbjct: 812 MQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQY 871
Query: 237 GLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
+ + C + K+ + K E + R+ AQ L D +A
Sbjct: 872 FSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSI 931
Query: 297 TSPSHAVVANVQL-----VLHLMKQHSKALC-NDRVINSI-----PLAKQVSSRGGKSKK 345
++ + ++ + +M +H + L D I S+ L V++ + ++
Sbjct: 932 AEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEE 991
Query: 346 LSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALV 405
L N +++ E L L+DE + Q K + T LK + +L ++
Sbjct: 992 L-------NNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERT--LKTQAVNKLAEIM 1042
Query: 406 GRME-AKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERN-SSSRSGITGTTNKK 463
R E K T VR+ + + K +E + + K T++ + ++ + ++ I + +
Sbjct: 1043 NRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIR 1102
Query: 464 DFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSL 496
+++ K QL +Q++ L SSS+
Sbjct: 1103 IELQMTLDSKDSDIEQLRSQLQALHIGLDSSSI 1135
Score = 42.7 bits (99), Expect = 8e-04
Identities = 90/455 (19%), Positives = 181/455 (39%), Gaps = 60/455 (13%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
ESN+R +LQDK LE +++ E +E I + L+ + ++R
Sbjct: 596 ESNNR-------DLQDKNCLLETAKLKLE-------KEFINLQSALESERRDRT------ 635
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHV 182
H E+ + L + + LE+ L+ + ++ E+E+ + E+ LE+E+ + + +
Sbjct: 636 --HGSEIINDL---QGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDM 690
Query: 183 QSQLEKL--DLLEQEYNKLTTMQALAEKK-------------MQELEAKLHEEEQERKRM 227
QL+ + L ++E T LA+K M+E+E KL EE + +
Sbjct: 691 TYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEE----RTL 746
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLG 287
+ K L E + + + K+K E + Q + CL
Sbjct: 747 KQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCL- 805
Query: 288 DMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRV---INSIPLAKQVSSRGGKSK 344
V +++ +KQ + L ++ + L K+ G+ K
Sbjct: 806 -----TQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMK 860
Query: 345 KLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEAL 404
+L + + ++ L++E + + ++L + QE + +D L +LE
Sbjct: 861 ELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQE--LQDERDSLAAQLEIT 918
Query: 405 VGRMEAKANQITKVRKYQAQLEKQKLEKQ---KKELKATKKTLDEERNSSSRSGITGTTN 461
+ + +++ + + + LEK+K+ K+ K+ + K+ L E+ + + T T
Sbjct: 919 LTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTL 978
Query: 462 KKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSL 496
D L EK N LKD+Q + L+ +
Sbjct: 979 TSDVANL-ANEKEELN-NKLKDVQEQLSRLKDEEI 1011
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/199 (20%), Positives = 83/199 (41%), Gaps = 13/199 (6%)
Query: 76 LQDKIRRLELERIQAE--ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
L D E + IQ+ E + + ++ ++ L ++Q +E + + N L
Sbjct: 422 LSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTA 481
Query: 134 LAAENKCNLLE------KQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLE 187
E + L + +QLE + +++H E + + +R ++D ++ QLE
Sbjct: 482 KELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLE 541
Query: 188 KLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRM---QAKAAELQTGLETNRLI 244
L Q T ++++ E A L E R+ QA++++ LE+N
Sbjct: 542 DLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRD 601
Query: 245 FEDKATPCVPNARRIKKKK 263
+DK C+ ++K +K
Sbjct: 602 LQDK--NCLLETAKLKLEK 618
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 61.2 bits (147), Expect = 2e-09
Identities = 39/157 (24%), Positives = 75/157 (47%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
++K+RR E + EE ++ L + E +K+ +++ + +E K E + QE +++
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 388
Query: 137 ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEY 196
E K E+++ M++ E + EK E E Q + ++ Q EK+ E++
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 197 NKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
+ E+ MQE E K+ E+E + +AK E
Sbjct: 449 REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE 485
Score = 48.9 bits (115), Expect = 1e-05
Identities = 40/159 (25%), Positives = 78/159 (49%), Gaps = 4/159 (2%)
Query: 76 LQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLA 135
LQ+K++ +E E+ + + +VK L R+ K +L +Q + E + + Q
Sbjct: 214 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 273
Query: 136 AENKC-NLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQ 194
EN+ N L +Q E + ER +++Q RE++ ++ Q E + E+
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEK---MRRQEEMMWEKEE 330
Query: 195 EYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
+ + M E+K++ELE K+HE+E+ R++ + + E
Sbjct: 331 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 369
Score = 48.9 bits (115), Expect = 1e-05
Identities = 46/202 (22%), Positives = 85/202 (42%), Gaps = 22/202 (10%)
Query: 49 DLRRSPSKPTLAYPESNSRA--------IFSALKNLQDKIRRLEL-ERIQAEESVKTLSR 99
+L+R + L P+ +A + S LQ ++ EL R+ ++ K +
Sbjct: 234 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293
Query: 100 ETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQL-----------E 148
E E + +E+IQE+E E+ + + + E K E+ + E
Sbjct: 294 E--EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351
Query: 149 YMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEK 208
M K E E E+++ + +RQ + + Q EK+ E++ + M E+
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411
Query: 209 KMQELEAKLHEEEQERKRMQAK 230
KM E E K+ E+E+E + + K
Sbjct: 412 KMGEQEEKMWEQEEEMQEQEEK 433
Score = 47.4 bits (111), Expect = 3e-05
Identities = 35/166 (21%), Positives = 73/166 (43%), Gaps = 3/166 (1%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQ---ERENSKNEESKHNQELTSQL 133
Q+K + E + + EE ++ + E ++++ EQ + E+E E+ + QE ++
Sbjct: 375 QEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKM 434
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
E K EK++ I+ E EK E + + +Q Q EK+ E
Sbjct: 435 RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQE 494
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLE 239
++ + E+K++E E + E+E++ + K E + ++
Sbjct: 495 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 540
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/158 (20%), Positives = 73/158 (46%), Gaps = 4/158 (2%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQ 132
++ ++KIR E E + E+ K +E +++ +E++QE+E + + +E +
Sbjct: 392 IREQEEKIR--EQEEMMQEQEEKMGEQEEKMWEQ--EEEMQEQEEKMRRQEEKIREQEKK 447
Query: 133 LLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLL 192
+ E K E+ ++ + E + K E + + + ++ Q +K+
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 193 EQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAK 230
E++ + M E+KM E E K+ E+E++ + + K
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 545
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/150 (22%), Positives = 67/150 (44%), Gaps = 3/150 (2%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQ---IQERENSKNEESKHNQELTSQL 133
++K+ E E + EE ++ + E +K + EQ I+E+E E+ + E ++
Sbjct: 417 EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKM 476
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
E K E+++ I+ E + EK E Q + + Q EK+ E
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 536
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQE 223
++ + E+KM+E E +L ++E++
Sbjct: 537 EKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/140 (24%), Positives = 60/140 (42%), Gaps = 4/140 (2%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQ 132
++ ++KIR E + + EE + RE E + +E++ E+E E+ QE +
Sbjct: 434 MRRQEEKIREQEKKIREQEEKI----REQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEK 489
Query: 133 LLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLL 192
+ E K EK++ I+ E EK E + + +Q Q EK+
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 549
Query: 193 EQEYNKLTTMQALAEKKMQE 212
E++ + E+KMQE
Sbjct: 550 EEKMREQEVRLRQQEEKMQE 569
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 60.5 bits (145), Expect = 4e-09
Identities = 94/424 (22%), Positives = 177/424 (41%), Gaps = 65/424 (15%)
Query: 55 SKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEES----VKTLSRETIEYKKVLDE 110
+K LA E+ + + L L + L+L+ +QAE + + I+ K L+
Sbjct: 860 TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ-VQAESENLLDAEERCDQLIKAKFQLEA 918
Query: 111 QIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMR--------------NMIKH 156
+I+E +E + N ELT++ E++C+ L+K ++ + N +K+
Sbjct: 919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 978
Query: 157 AEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAK 216
E + + E L RE++ Q Q L+ L E + N L ++ E+++++LE+
Sbjct: 979 LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038
Query: 217 LHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYF 276
L EQE+K L+ LE N+ E + ++ K + E+ +++
Sbjct: 1039 L---EQEKK--------LRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFE 1087
Query: 277 GAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQV 336
Q ++ + Q + ++ + L + AK
Sbjct: 1088 YCQLQSKV-------------EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 337 SSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDK 396
R +++L EELSE L +E G ++ +L K +E+ ++L+
Sbjct: 1135 KQRSDYAREL-----------EELSERL----EEAGGVTSTQIELNKK-REAEFLKLRRD 1178
Query: 397 LE---CELEALVGRMEAK-ANQITKVRKYQAQLE--KQKLEKQKKELKATKKTLDEERNS 450
LE + EA+V + K A+ + ++ + L+ KQKLEK+K E K L S
Sbjct: 1179 LEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Query: 451 SSRS 454
S+S
Sbjct: 1239 VSKS 1242
Score = 52.4 bits (124), Expect = 1e-06
Identities = 95/484 (19%), Positives = 195/484 (40%), Gaps = 62/484 (12%)
Query: 60 AYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSR---------ETIEYKKVLDE 110
A ++NS K D I+R E + EE+ K L++ E + K E
Sbjct: 1361 ALSKANSEVAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 111 QIQERENSKNEESKHNQELTSQLLAA-ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQV 169
+ ++R + E+ + E + L AA + K +K L + + ++ E + L++
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Query: 170 SLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQA 229
SL E + + L++L+ +++E L A +++ E +HE E+ RK+++
Sbjct: 1477 SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIEL 1536
Query: 230 KAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQ--PHYRLCLG 287
+ A++Q LE E + + + + KS+ K + ++ Q +Y+ +
Sbjct: 1537 EKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVE 1596
Query: 288 DMPFVAGKSTSPSHAVVA----------NVQLVL-HLMKQHSKALCNDRVI------NSI 330
M + + +++ L H +Q ++ L + R + +
Sbjct: 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 331 PLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDE------FGQMSFDHQQLAKL 384
L + + ++L++ +N + E+ E+ TL+ Q D + +L
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Query: 385 I--QESPTVELKDKLECELEALVGRMEAKANQ-----------ITKVRKYQAQLEKQK-- 429
+ Q + + K KLE +L L +E + IT +L+K++
Sbjct: 1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Query: 430 ---LEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQS 486
LE+ KK L+ T K L + + + + G KK KL E R + L+ + +
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKG--GKKQIQKL---ETRIRELEFELEGEQ 1831
Query: 487 IQNS 490
+N+
Sbjct: 1832 KKNT 1835
Score = 49.3 bits (116), Expect = 8e-06
Identities = 85/461 (18%), Positives = 192/461 (41%), Gaps = 43/461 (9%)
Query: 73 LKNLQDKIRRLELERIQAE-------ESVKTLSRETIEYKKV---LDEQIQERENSKNEE 122
+ NLQ ++LE E+ + + S++++S+ +K+ L++Q+ E E
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMI------KHAEMERTSVLEKQVSLERERQ 176
+ ELT+Q + + L +QLE +++ K A ++T L++Q+ E + +
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK 1327
Query: 177 HDQTH-VQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
+ H +QS DLL ++Y + +A ++ + + + E Q R + + A +
Sbjct: 1328 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS---EVAQWRTKYETDAIQRT 1384
Query: 236 TGLE------TNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDM 289
LE RL ++ V NA+ +K+K + + +
Sbjct: 1385 EELEEAKKKLAQRLQDSEEQVEAV-NAKCASLEKTKQRLQGEVEDLMVDVER----ANSL 1439
Query: 290 PFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVT 349
K V+A + + +A + S L K ++ +L
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV 1499
Query: 350 PPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQ-ESPTVELK-DKLECEL---EAL 404
+ + +E++++ + + E G+ + ++ K I+ E ++L ++ E L EA
Sbjct: 1500 KRENKNLEQEIADLTEQIA-ENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 1558
Query: 405 VGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKD 464
+ R++ + Q+ + + +++E+ K+ + T +T+ ++ RS KK
Sbjct: 1559 ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKK 1618
Query: 465 F------MKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWD 499
++++ R+ + LK ++S+Q L+ + L D
Sbjct: 1619 MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659
Score = 41.2 bits (95), Expect = 0.002
Identities = 79/381 (20%), Positives = 152/381 (39%), Gaps = 56/381 (14%)
Query: 98 SRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHA 157
S ET + + E+ Q+ ++ + +EL +L+ + N L+ Q++ + A
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 158 EMERTSVLEKQVSLER------ERQHDQTHVQSQLE-KLDLLEQEYNKLTTMQALAEKKM 210
E +++ + LE ER D+ + ++L K LE E ++L +K +
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL-------KKDI 955
Query: 211 QELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKK 270
+LE L + E+E+ + K L T L D+ A+ ++KK+
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNL-----TEELSGLDETI-----AKLTREKKA------ 999
Query: 271 SSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLV--LHLMKQHSKALCNDRVIN 328
Q ++ L D+ K S + Q V L + K L D N
Sbjct: 1000 -------LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN 1052
Query: 329 SIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQES 388
L + K + S+ +L Q L + + F++ QL +++
Sbjct: 1053 KRKLEGDL-----KLAQESIL---------DLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098
Query: 389 PTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEER 448
T+ L + + +++ L R+E +I R +A+ EKQ+ + +EL+ + L+E
Sbjct: 1099 QTLGL--QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD-YARELEELSERLEEAG 1155
Query: 449 NSSSRSGITGTTNKKDFMKLR 469
+S + +F+KLR
Sbjct: 1156 GVTSTQIELNKKREAEFLKLR 1176
Score = 34.3 bits (77), Expect = 0.27
Identities = 90/472 (19%), Positives = 192/472 (40%), Gaps = 70/472 (14%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLS-RETIEYKKVLDE--------------QIQEREN 117
+K LQ +I LE E I+AE + + + ++ +Y + L+E QI+ +
Sbjct: 1109 IKELQARIEELE-EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK 1167
Query: 118 SKNEESKHNQELTSQLLAAENKCNLLEK-----------QLEYMRNMIKHAEMERT---- 162
+ E K ++L L E L K Q++ ++ + + E E++
Sbjct: 1168 REAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1227
Query: 163 ----------SVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQE 212
SV + + +LE+ + + + K + +++ ++LTT ++ + + E
Sbjct: 1228 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE 1287
Query: 213 LEAKLHEEEQERKRM-QAKAAELQTGLETNR-LIFEDKATPCVPNARRIKKKKSKPPEKK 270
L +L E+E ++ ++K A Q E R L E+KA + +A + + ++
Sbjct: 1288 LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQ 1347
Query: 271 SSRNYFG-AQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINS 329
G A+ L + ++ + A+ +L + +K R+ +S
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL------EEAKKKLAQRLQDS 1401
Query: 330 IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESP 389
+QV + K L T G E+L ++ + + K++ E
Sbjct: 1402 ---EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK 1458
Query: 390 TVELKDKLECELEALVGRMEAKANQITKVRK-YQAQLEKQKLEKQKKELKATKKTLDEER 448
T ++ + ELEA + + + ++ K++ Y+ L+ +LE K+E K ++ + +
Sbjct: 1459 T--KCEESQAELEASLKESRSLSTELFKLKNAYEEALD--QLETVKRENKNLEQEIADLT 1514
Query: 449 NSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWDY 500
+ +G T + EK RK ++L K IQ +L+ + ++
Sbjct: 1515 EQIAENGKT----------IHELEKSRKQIELEK--ADIQLALEEAEAALEH 1554
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 60.1 bits (144), Expect = 5e-09
Identities = 95/460 (20%), Positives = 184/460 (40%), Gaps = 71/460 (15%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTL--SRETIEYKKV-LDEQIQERENSKNEESKHNQE 128
A NL + LE E ++ L +++ +E+KK L+ Q+QE ++ ++ + E
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 129 L--------------TSQLLAAENKCNLLEK-------QLEYMRNMIKHAEMERTSVLEK 167
L T L AE K L K QL+ + +++ ++ +V K
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 168 QVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRM 227
LE ER Q + ++E LE+ + L + ++KK+Q+ + + E+ +KR
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSK------------PPEKKSSRNY 275
Q + L E ++ +++K K++ +++ N
Sbjct: 1398 QKEIENLTQQYEEKAAAYD-----------KLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
Q + L + ++ K A + ++ +KAL R + AK+
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAR------EKETKALSLARALEEALEAKE 1500
Query: 336 VSSRGGKSKKLS----VTPPSSNGIN-EELSEVLQTLQDEFGQMSFDHQQL--------- 381
R K K V+ G N EL + + L+ + +M ++L
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 382 AKLIQESPTVELKDKLECELEALVGRMEAKANQITK-VRKYQAQLEKQKLEKQKKELKAT 440
AKL E LK + E +L+A + E K Q+ + + +Y+ +LE ++ KQ+ A
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER--KQRALAAAA 1618
Query: 441 KKTLDEERNSSSRSGITGTTNKKDFMK-LRPGEKRRKNLQ 479
KK L+ + + +++ +K LR + + K+ Q
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Score = 56.6 bits (135), Expect = 5e-08
Identities = 96/490 (19%), Positives = 193/490 (39%), Gaps = 99/490 (20%)
Query: 77 QDKIRRLELERIQAEESVKTLSR---ETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
+D++++ + + +AE +K L + + E K +L EQ+Q E + L ++
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS-QLEKLD-- 190
E + +E +LE + + + ER + ++ + LE + + ++ Q QLEK+
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 191 -----------LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK---RMQAKAAELQT 236
+++ + NKL+ + L E+++ +L L EEE++ K +++ K + +
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 237 GLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
LE R K++KS+ +K R G + + D+
Sbjct: 1038 ELEV----------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADL------- 1074
Query: 297 TSPSHAVVANVQLVLHLMKQHSKALC---NDRVINSIPLAKQVSSRGGKSKKLSVTPPSS 353
A +A +++ L ++ +A +D + K++ G L S
Sbjct: 1075 ----QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 354 NG-----------INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTV----------- 391
+ EEL + L+D + + AK QE +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 392 -----ELKDKLECELEALVGRME----AKAN---QITKVRKYQAQLE---------KQKL 430
E++ K +E L ++E AKAN + K A L KQ++
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 431 EKQKKELKATKKTLDEERNSSSRS------GITGTTNKKDFMKLRPGEKRRKNLQLLKDM 484
E +KK+L+A + L + + R+ + N+ + + E K ++L KD+
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 485 QSIQNSLQSS 494
S+ + LQ +
Sbjct: 1311 ASLSSQLQDT 1320
Score = 52.8 bits (125), Expect = 7e-07
Identities = 81/380 (21%), Positives = 153/380 (40%), Gaps = 87/380 (22%)
Query: 96 TLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK 155
T E ++ K+ ++ +ER+ E K ++ SQL E K NLL++QL+ +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL--TEEK-NLLQEQLQAETELYA 904
Query: 156 HAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEA 215
AE R + K+ LE + ++ + ++ L+ E K+ ++M +LE
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEE 957
Query: 216 KLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNY 275
+L EEE R+++Q + + ++ ED+ ++ K++ E+ S
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKK----LEDEILVMDDQNNKLSKERKLLEERIS---- 1009
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
L +L ++ KA L K
Sbjct: 1010 --------------------------------DLTTNLAEEEEKAK---------NLTKL 1028
Query: 336 VSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKD 395
+ +L V +EL ++ + L+ G S H+Q+A L ++ ELK
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADL--QAQIAELKM 1083
Query: 396 KL---ECELEALVGRME----AKANQITKVRKYQAQLE------------KQKLEKQKK- 435
+L E EL+A + R++ K N + K+R+ + + + K EKQK+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 436 ---ELKATKKTLDEERNSSS 452
EL+A K L++ +S++
Sbjct: 1144 LGEELEALKTELEDTLDSTA 1163
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/436 (19%), Positives = 175/436 (40%), Gaps = 34/436 (7%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSK-----NEES--KHNQELTSQL 133
+ L+ E E V+ + ++ + + L EQ+++ + +K N+++ K N +L +L
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 134 LA-------AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQL 186
E+K LE Q++ +++ E R + +K L+ E V+S
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE-------VESVT 1293
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
L+ E + KL A ++Q+ + L EE +++ + K +L+ + + +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAG-KSTSPSHAVVA 305
++ R I + + K F A L G F ++ + + A
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
L K + +D V++ + VS+ K +K I+ + ++
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
+ E + LA+ ++E+ +E K++LE + L ME + V K +L
Sbjct: 1473 RAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 426 EKQK--LEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDF-------MKLRPGEKRRK 476
EK K LE Q +E+K + L++E ++ + + N + ++ R + K
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 477 NLQLLKDMQSIQNSLQ 492
QL + + + L+
Sbjct: 1591 RRQLQRQLHEYETELE 1606
Score = 45.1 bits (105), Expect = 2e-04
Identities = 93/494 (18%), Positives = 189/494 (38%), Gaps = 61/494 (12%)
Query: 49 DLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVL 108
+++ S SK L S A+ K Q +I L + + + L + ++ L
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 109 DEQIQERENSKNEES--KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLE 166
D+ + + +N + S + Q QLLA E N+ K + A + T L
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALS 1487
Query: 167 K----QVSLERERQHDQTHVQSQLEKLDLLEQE------YNKLTTMQALAEKKMQELEAK 216
+ +LE + + ++T+ + E DL+ + ++L + E +M+E++ +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 217 LHEEEQERKRMQAKAAELQTGLETNRLIFE-DKATPCVPNARRIKKKKSK--------PP 267
L E E E + + L+ ++ + FE D N + ++ + +
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 268 EKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVI 327
E+K A+ L D+ A + + ++ + MK + L + R
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 328 -NSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAK--- 383
+ I + + + KS + + +L E L + Q + ++LA+
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLM---------QLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 384 --------LIQESPTVELK-DKLECELEALVGRMEAKANQITKVRKYQAQLE-------- 426
L E +E + +LE ELE G MEA ++++ K + QL
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 427 --------KQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNL 478
+Q+LE+Q KEL++ ++ S +S I K ++ + ++ R+
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 479 QLLKDMQSIQNSLQ 492
K ++ L+
Sbjct: 1839 AATKSLKQKDKKLK 1852
Score = 41.6 bits (96), Expect = 0.002
Identities = 80/398 (20%), Positives = 161/398 (40%), Gaps = 40/398 (10%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E + RA+ + ++ ++ ++ LE + +QA E K ++ K E+ + + +NEE
Sbjct: 1531 EKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 123 SKHNQELTSQLLAAENKCNLLEKQL-------EYMRNMIKHAEMERTSVLEKQVSLERER 175
+ ++L QL E + KQ + + +K E++ S ++ + ++
Sbjct: 1590 KR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 176 QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
+ Q ++ +L+ +++ EKK + LEA L + +++ A+ A Q
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED--LAAAERARKQ 1705
Query: 236 TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGK 295
LE L E ++ NA + +K++ + + Q G+M ++ +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-------GNMEAMSDR 1758
Query: 296 STSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNG 355
A QL L + S A N+ A+Q R K + S
Sbjct: 1759 VRK---ATQQAEQLSNELATERSTAQKNES-------ARQQLERQNKELR-SKLHEMEGA 1807
Query: 356 INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI 415
+ + + L+ + Q+ +Q A+ +++ T LK K + E L+ Q+
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILL--------QV 1858
Query: 416 TKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSR 453
RK A+ K++ EK +K K+ L+E S R
Sbjct: 1859 EDERK-MAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Score = 36.2 bits (82), Expect = 0.071
Identities = 38/183 (20%), Positives = 76/183 (41%), Gaps = 20/183 (10%)
Query: 59 LAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENS 118
LA S ++ SA + L+ + + L + + E +VK+ + TI L+ +I + E
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA---ALEAKIAQLEEQ 1829
Query: 119 KNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHD 178
+E++ Q T L + K + Q+E R M + + + +
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ--------------YKEQAEKG 1875
Query: 179 QTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL 238
V+ +L+ E+E ++ A K +EL+ E + + A ++L+ G
Sbjct: 1876 NARVKQLKRQLEEAEEESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Query: 239 ETN 241
ET+
Sbjct: 1933 ETS 1935
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 60.1 bits (144), Expect = 5e-09
Identities = 95/460 (20%), Positives = 184/460 (40%), Gaps = 71/460 (15%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTL--SRETIEYKKV-LDEQIQERENSKNEESKHNQE 128
A NL + LE E ++ L +++ +E+KK L+ Q+QE ++ ++ + E
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 129 L--------------TSQLLAAENKCNLLEK-------QLEYMRNMIKHAEMERTSVLEK 167
L T L AE K L K QL+ + +++ ++ +V K
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 168 QVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRM 227
LE ER Q + ++E LE+ + L + ++KK+Q+ + + E+ +KR
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSK------------PPEKKSSRNY 275
Q + L E ++ +++K K++ +++ N
Sbjct: 1405 QKEIENLTQQYEEKAAAYD-----------KLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
Q + L + ++ K A + ++ +KAL R + AK+
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAR------EKETKALSLARALEEALEAKE 1507
Query: 336 VSSRGGKSKKLS----VTPPSSNGIN-EELSEVLQTLQDEFGQMSFDHQQL--------- 381
R K K V+ G N EL + + L+ + +M ++L
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 382 AKLIQESPTVELKDKLECELEALVGRMEAKANQITK-VRKYQAQLEKQKLEKQKKELKAT 440
AKL E LK + E +L+A + E K Q+ + + +Y+ +LE ++ KQ+ A
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER--KQRALAAAA 1625
Query: 441 KKTLDEERNSSSRSGITGTTNKKDFMK-LRPGEKRRKNLQ 479
KK L+ + + +++ +K LR + + K+ Q
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Score = 56.6 bits (135), Expect = 5e-08
Identities = 96/490 (19%), Positives = 193/490 (39%), Gaps = 99/490 (20%)
Query: 77 QDKIRRLELERIQAEESVKTLSR---ETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
+D++++ + + +AE +K L + + E K +L EQ+Q E + L ++
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS-QLEKLD-- 190
E + +E +LE + + + ER + ++ + LE + + ++ Q QLEK+
Sbjct: 925 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 191 -----------LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK---RMQAKAAELQT 236
+++ + NKL+ + L E+++ +L L EEE++ K +++ K + +
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 237 GLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
LE R K++KS+ +K R G + + D+
Sbjct: 1045 ELEV----------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADL------- 1081
Query: 297 TSPSHAVVANVQLVLHLMKQHSKALC---NDRVINSIPLAKQVSSRGGKSKKLSVTPPSS 353
A +A +++ L ++ +A +D + K++ G L S
Sbjct: 1082 ----QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 354 NG-----------INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTV----------- 391
+ EEL + L+D + + AK QE +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 392 -----ELKDKLECELEALVGRME----AKAN---QITKVRKYQAQLE---------KQKL 430
E++ K +E L ++E AKAN + K A L KQ++
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 431 EKQKKELKATKKTLDEERNSSSRS------GITGTTNKKDFMKLRPGEKRRKNLQLLKDM 484
E +KK+L+A + L + + R+ + N+ + + E K ++L KD+
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 485 QSIQNSLQSS 494
S+ + LQ +
Sbjct: 1318 ASLSSQLQDT 1327
Score = 52.8 bits (125), Expect = 7e-07
Identities = 81/380 (21%), Positives = 153/380 (40%), Gaps = 87/380 (22%)
Query: 96 TLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK 155
T E ++ K+ ++ +ER+ E K ++ SQL E K NLL++QL+ +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL--TEEK-NLLQEQLQAETELYA 911
Query: 156 HAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEA 215
AE R + K+ LE + ++ + ++ L+ E K+ ++M +LE
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEE 964
Query: 216 KLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNY 275
+L EEE R+++Q + + ++ ED+ ++ K++ E+ S
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKK----LEDEILVMDDQNNKLSKERKLLEERIS---- 1016
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
L +L ++ KA L K
Sbjct: 1017 --------------------------------DLTTNLAEEEEKAK---------NLTKL 1035
Query: 336 VSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKD 395
+ +L V +EL ++ + L+ G S H+Q+A L ++ ELK
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADL--QAQIAELKM 1090
Query: 396 KL---ECELEALVGRME----AKANQITKVRKYQAQLE------------KQKLEKQKK- 435
+L E EL+A + R++ K N + K+R+ + + + K EKQK+
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 436 ---ELKATKKTLDEERNSSS 452
EL+A K L++ +S++
Sbjct: 1151 LGEELEALKTELEDTLDSTA 1170
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/436 (19%), Positives = 175/436 (40%), Gaps = 34/436 (7%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSK-----NEES--KHNQELTSQL 133
+ L+ E E V+ + ++ + + L EQ+++ + +K N+++ K N +L +L
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 134 LA-------AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQL 186
E+K LE Q++ +++ E R + +K L+ E V+S
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE-------VESVT 1300
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
L+ E + KL A ++Q+ + L EE +++ + K +L+ + + +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAG-KSTSPSHAVVA 305
++ R I + + K F A L G F ++ + + A
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
L K + +D V++ + VS+ K +K I+ + ++
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
+ E + LA+ ++E+ +E K++LE + L ME + V K +L
Sbjct: 1480 RAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 426 EKQK--LEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDF-------MKLRPGEKRRK 476
EK K LE Q +E+K + L++E ++ + + N + ++ R + K
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 477 NLQLLKDMQSIQNSLQ 492
QL + + + L+
Sbjct: 1598 RRQLQRQLHEYETELE 1613
Score = 45.1 bits (105), Expect = 2e-04
Identities = 93/494 (18%), Positives = 189/494 (38%), Gaps = 61/494 (12%)
Query: 49 DLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVL 108
+++ S SK L S A+ K Q +I L + + + L + ++ L
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 109 DEQIQERENSKNEES--KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLE 166
D+ + + +N + S + Q QLLA E N+ K + A + T L
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALS 1494
Query: 167 K----QVSLERERQHDQTHVQSQLEKLDLLEQE------YNKLTTMQALAEKKMQELEAK 216
+ +LE + + ++T+ + E DL+ + ++L + E +M+E++ +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 217 LHEEEQERKRMQAKAAELQTGLETNRLIFE-DKATPCVPNARRIKKKKSK--------PP 267
L E E E + + L+ ++ + FE D N + ++ + +
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 268 EKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVI 327
E+K A+ L D+ A + + ++ + MK + L + R
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 328 -NSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAK--- 383
+ I + + + KS + + +L E L + Q + ++LA+
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLM---------QLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 384 --------LIQESPTVELK-DKLECELEALVGRMEAKANQITKVRKYQAQLE-------- 426
L E +E + +LE ELE G MEA ++++ K + QL
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 427 --------KQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNL 478
+Q+LE+Q KEL++ ++ S +S I K ++ + ++ R+
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 479 QLLKDMQSIQNSLQ 492
K ++ L+
Sbjct: 1846 AATKSLKQKDKKLK 1859
Score = 41.6 bits (96), Expect = 0.002
Identities = 80/398 (20%), Positives = 161/398 (40%), Gaps = 40/398 (10%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E + RA+ + ++ ++ ++ LE + +QA E K ++ K E+ + + +NEE
Sbjct: 1538 EKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 123 SKHNQELTSQLLAAENKCNLLEKQL-------EYMRNMIKHAEMERTSVLEKQVSLERER 175
+ ++L QL E + KQ + + +K E++ S ++ + ++
Sbjct: 1597 KR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 176 QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
+ Q ++ +L+ +++ EKK + LEA L + +++ A+ A Q
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED--LAAAERARKQ 1712
Query: 236 TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGK 295
LE L E ++ NA + +K++ + + Q G+M ++ +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-------GNMEAMSDR 1765
Query: 296 STSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNG 355
A QL L + S A N+ A+Q R K + S
Sbjct: 1766 VRK---ATQQAEQLSNELATERSTAQKNES-------ARQQLERQNKELR-SKLHEMEGA 1814
Query: 356 INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI 415
+ + + L+ + Q+ +Q A+ +++ T LK K + E L+ Q+
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILL--------QV 1865
Query: 416 TKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSR 453
RK A+ K++ EK +K K+ L+E S R
Sbjct: 1866 EDERK-MAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Score = 36.2 bits (82), Expect = 0.071
Identities = 38/183 (20%), Positives = 76/183 (41%), Gaps = 20/183 (10%)
Query: 59 LAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENS 118
LA S ++ SA + L+ + + L + + E +VK+ + TI L+ +I + E
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA---ALEAKIAQLEEQ 1836
Query: 119 KNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHD 178
+E++ Q T L + K + Q+E R M + + + +
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ--------------YKEQAEKG 1882
Query: 179 QTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL 238
V+ +L+ E+E ++ A K +EL+ E + + A ++L+ G
Sbjct: 1883 NARVKQLKRQLEEAEEESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Query: 239 ETN 241
ET+
Sbjct: 1940 ETS 1942
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 60.1 bits (144), Expect = 5e-09
Identities = 95/460 (20%), Positives = 184/460 (40%), Gaps = 71/460 (15%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTL--SRETIEYKKV-LDEQIQERENSKNEESKHNQE 128
A NL + LE E ++ L +++ +E+KK L+ Q+QE ++ ++ + E
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 129 L--------------TSQLLAAENKCNLLEK-------QLEYMRNMIKHAEMERTSVLEK 167
L T L AE K L K QL+ + +++ ++ +V K
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 168 QVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRM 227
LE ER Q + ++E LE+ + L + ++KK+Q+ + + E+ +KR
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSK------------PPEKKSSRNY 275
Q + L E ++ +++K K++ +++ N
Sbjct: 1405 QKEIENLTQQYEEKAAAYD-----------KLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
Q + L + ++ K A + ++ +KAL R + AK+
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAR------EKETKALSLARALEEALEAKE 1507
Query: 336 VSSRGGKSKKLS----VTPPSSNGIN-EELSEVLQTLQDEFGQMSFDHQQL--------- 381
R K K V+ G N EL + + L+ + +M ++L
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 382 AKLIQESPTVELKDKLECELEALVGRMEAKANQITK-VRKYQAQLEKQKLEKQKKELKAT 440
AKL E LK + E +L+A + E K Q+ + + +Y+ +LE ++ KQ+ A
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER--KQRALAAAA 1625
Query: 441 KKTLDEERNSSSRSGITGTTNKKDFMK-LRPGEKRRKNLQ 479
KK L+ + + +++ +K LR + + K+ Q
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Score = 56.6 bits (135), Expect = 5e-08
Identities = 96/490 (19%), Positives = 193/490 (39%), Gaps = 99/490 (20%)
Query: 77 QDKIRRLELERIQAEESVKTLSR---ETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
+D++++ + + +AE +K L + + E K +L EQ+Q E + L ++
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS-QLEKLD-- 190
E + +E +LE + + + ER + ++ + LE + + ++ Q QLEK+
Sbjct: 925 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 984
Query: 191 -----------LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK---RMQAKAAELQT 236
+++ + NKL+ + L E+++ +L L EEE++ K +++ K + +
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 237 GLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
LE R K++KS+ +K R G + + D+
Sbjct: 1045 ELEV----------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADL------- 1081
Query: 297 TSPSHAVVANVQLVLHLMKQHSKALC---NDRVINSIPLAKQVSSRGGKSKKLSVTPPSS 353
A +A +++ L ++ +A +D + K++ G L S
Sbjct: 1082 ----QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 354 NG-----------INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTV----------- 391
+ EEL + L+D + + AK QE +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 392 -----ELKDKLECELEALVGRME----AKAN---QITKVRKYQAQLE---------KQKL 430
E++ K +E L ++E AKAN + K A L KQ++
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 431 EKQKKELKATKKTLDEERNSSSRS------GITGTTNKKDFMKLRPGEKRRKNLQLLKDM 484
E +KK+L+A + L + + R+ + N+ + + E K ++L KD+
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 485 QSIQNSLQSS 494
S+ + LQ +
Sbjct: 1318 ASLSSQLQDT 1327
Score = 52.8 bits (125), Expect = 7e-07
Identities = 81/380 (21%), Positives = 153/380 (40%), Gaps = 87/380 (22%)
Query: 96 TLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK 155
T E ++ K+ ++ +ER+ E K ++ SQL E K NLL++QL+ +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL--TEEK-NLLQEQLQAETELYA 911
Query: 156 HAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEA 215
AE R + K+ LE + ++ + ++ L+ E K+ ++M +LE
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEE 964
Query: 216 KLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNY 275
+L EEE R+++Q + + ++ ED+ ++ K++ E+ S
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKK----LEDEILVMDDQNNKLSKERKLLEERIS---- 1016
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
L +L ++ KA L K
Sbjct: 1017 --------------------------------DLTTNLAEEEEKAK---------NLTKL 1035
Query: 336 VSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKD 395
+ +L V +EL ++ + L+ G S H+Q+A L ++ ELK
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADL--QAQIAELKM 1090
Query: 396 KL---ECELEALVGRME----AKANQITKVRKYQAQLE------------KQKLEKQKK- 435
+L E EL+A + R++ K N + K+R+ + + + K EKQK+
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 436 ---ELKATKKTLDEERNSSS 452
EL+A K L++ +S++
Sbjct: 1151 LGEELEALKTELEDTLDSTA 1170
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/436 (19%), Positives = 175/436 (40%), Gaps = 34/436 (7%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSK-----NEES--KHNQELTSQL 133
+ L+ E E V+ + ++ + + L EQ+++ + +K N+++ K N +L +L
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 134 LA-------AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQL 186
E+K LE Q++ +++ E R + +K L+ E V+S
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE-------VESVT 1300
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
L+ E + KL A ++Q+ + L EE +++ + K +L+ + + +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAG-KSTSPSHAVVA 305
++ R I + + K F A L G F ++ + + A
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
L K + +D V++ + VS+ K +K I+ + ++
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
+ E + LA+ ++E+ +E K++LE + L ME + V K +L
Sbjct: 1480 RAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 426 EKQK--LEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDF-------MKLRPGEKRRK 476
EK K LE Q +E+K + L++E ++ + + N + ++ R + K
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 477 NLQLLKDMQSIQNSLQ 492
QL + + + L+
Sbjct: 1598 RRQLQRQLHEYETELE 1613
Score = 45.1 bits (105), Expect = 2e-04
Identities = 93/494 (18%), Positives = 189/494 (38%), Gaps = 61/494 (12%)
Query: 49 DLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVL 108
+++ S SK L S A+ K Q +I L + + + L + ++ L
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 109 DEQIQERENSKNEES--KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLE 166
D+ + + +N + S + Q QLLA E N+ K + A + T L
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALS 1494
Query: 167 K----QVSLERERQHDQTHVQSQLEKLDLLEQE------YNKLTTMQALAEKKMQELEAK 216
+ +LE + + ++T+ + E DL+ + ++L + E +M+E++ +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 217 LHEEEQERKRMQAKAAELQTGLETNRLIFE-DKATPCVPNARRIKKKKSK--------PP 267
L E E E + + L+ ++ + FE D N + ++ + +
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 268 EKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVI 327
E+K A+ L D+ A + + ++ + MK + L + R
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 328 -NSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAK--- 383
+ I + + + KS + + +L E L + Q + ++LA+
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLM---------QLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 384 --------LIQESPTVELK-DKLECELEALVGRMEAKANQITKVRKYQAQLE-------- 426
L E +E + +LE ELE G MEA ++++ K + QL
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 427 --------KQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNL 478
+Q+LE+Q KEL++ ++ S +S I K ++ + ++ R+
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 479 QLLKDMQSIQNSLQ 492
K ++ L+
Sbjct: 1846 AATKSLKQKDKKLK 1859
Score = 41.6 bits (96), Expect = 0.002
Identities = 80/398 (20%), Positives = 161/398 (40%), Gaps = 40/398 (10%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E + RA+ + ++ ++ ++ LE + +QA E K ++ K E+ + + +NEE
Sbjct: 1538 EKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 123 SKHNQELTSQLLAAENKCNLLEKQL-------EYMRNMIKHAEMERTSVLEKQVSLERER 175
+ ++L QL E + KQ + + +K E++ S ++ + ++
Sbjct: 1597 KR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 176 QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
+ Q ++ +L+ +++ EKK + LEA L + +++ A+ A Q
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED--LAAAERARKQ 1712
Query: 236 TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGK 295
LE L E ++ NA + +K++ + + Q G+M ++ +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-------GNMEAMSDR 1765
Query: 296 STSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNG 355
A QL L + S A N+ A+Q R K + S
Sbjct: 1766 VRK---ATQQAEQLSNELATERSTAQKNES-------ARQQLERQNKELR-SKLHEMEGA 1814
Query: 356 INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI 415
+ + + L+ + Q+ +Q A+ +++ T LK K + E L+ Q+
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILL--------QV 1865
Query: 416 TKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSR 453
RK A+ K++ EK +K K+ L+E S R
Sbjct: 1866 EDERK-MAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 60.1 bits (144), Expect = 5e-09
Identities = 95/460 (20%), Positives = 184/460 (40%), Gaps = 71/460 (15%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTL--SRETIEYKKV-LDEQIQERENSKNEESKHNQE 128
A NL + LE E ++ L +++ +E+KK L+ Q+QE ++ ++ + E
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 129 L--------------TSQLLAAENKCNLLEK-------QLEYMRNMIKHAEMERTSVLEK 167
L T L AE K L K QL+ + +++ ++ +V K
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 168 QVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRM 227
LE ER Q + ++E LE+ + L + ++KK+Q+ + + E+ +KR
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSK------------PPEKKSSRNY 275
Q + L E ++ +++K K++ +++ N
Sbjct: 1398 QKEIENLTQQYEEKAAAYD-----------KLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
Q + L + ++ K A + ++ +KAL R + AK+
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAR------EKETKALSLARALEEALEAKE 1500
Query: 336 VSSRGGKSKKLS----VTPPSSNGIN-EELSEVLQTLQDEFGQMSFDHQQL--------- 381
R K K V+ G N EL + + L+ + +M ++L
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 382 AKLIQESPTVELKDKLECELEALVGRMEAKANQITK-VRKYQAQLEKQKLEKQKKELKAT 440
AKL E LK + E +L+A + E K Q+ + + +Y+ +LE ++ KQ+ A
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER--KQRALAAAA 1618
Query: 441 KKTLDEERNSSSRSGITGTTNKKDFMK-LRPGEKRRKNLQ 479
KK L+ + + +++ +K LR + + K+ Q
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Score = 56.6 bits (135), Expect = 5e-08
Identities = 96/490 (19%), Positives = 193/490 (39%), Gaps = 99/490 (20%)
Query: 77 QDKIRRLELERIQAEESVKTLSR---ETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
+D++++ + + +AE +K L + + E K +L EQ+Q E + L ++
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS-QLEKLD-- 190
E + +E +LE + + + ER + ++ + LE + + ++ Q QLEK+
Sbjct: 918 QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE 977
Query: 191 -----------LLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK---RMQAKAAELQT 236
+++ + NKL+ + L E+++ +L L EEE++ K +++ K + +
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 237 GLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
LE R K++KS+ +K R G + + D+
Sbjct: 1038 ELEV----------------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADL------- 1074
Query: 297 TSPSHAVVANVQLVLHLMKQHSKALC---NDRVINSIPLAKQVSSRGGKSKKLSVTPPSS 353
A +A +++ L ++ +A +D + K++ G L S
Sbjct: 1075 ----QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 354 NG-----------INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTV----------- 391
+ EEL + L+D + + AK QE +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 392 -----ELKDKLECELEALVGRME----AKAN---QITKVRKYQAQLE---------KQKL 430
E++ K +E L ++E AKAN + K A L KQ++
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 431 EKQKKELKATKKTLDEERNSSSRS------GITGTTNKKDFMKLRPGEKRRKNLQLLKDM 484
E +KK+L+A + L + + R+ + N+ + + E K ++L KD+
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 485 QSIQNSLQSS 494
S+ + LQ +
Sbjct: 1311 ASLSSQLQDT 1320
Score = 52.8 bits (125), Expect = 7e-07
Identities = 81/380 (21%), Positives = 153/380 (40%), Gaps = 87/380 (22%)
Query: 96 TLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK 155
T E ++ K+ ++ +ER+ E K ++ SQL E K NLL++QL+ +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQL--TEEK-NLLQEQLQAETELYA 904
Query: 156 HAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEA 215
AE R + K+ LE + ++ + ++ L+ E K+ ++M +LE
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA-------QQMLDLEE 957
Query: 216 KLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNY 275
+L EEE R+++Q + + ++ ED+ ++ K++ E+ S
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKK----LEDEILVMDDQNNKLSKERKLLEERIS---- 1009
Query: 276 FGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQ 335
L +L ++ KA L K
Sbjct: 1010 --------------------------------DLTTNLAEEEEKAK---------NLTKL 1028
Query: 336 VSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKD 395
+ +L V +EL ++ + L+ G S H+Q+A L ++ ELK
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLE---GDASDFHEQIADL--QAQIAELKM 1083
Query: 396 KL---ECELEALVGRME----AKANQITKVRKYQAQLE------------KQKLEKQKK- 435
+L E EL+A + R++ K N + K+R+ + + + K EKQK+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 436 ---ELKATKKTLDEERNSSS 452
EL+A K L++ +S++
Sbjct: 1144 LGEELEALKTELEDTLDSTA 1163
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/436 (19%), Positives = 175/436 (40%), Gaps = 34/436 (7%)
Query: 81 RRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSK-----NEES--KHNQELTSQL 133
+ L+ E E V+ + ++ + + L EQ+++ + +K N+++ K N +L +L
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 134 LA-------AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQL 186
E+K LE Q++ +++ E R + +K L+ E V+S
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE-------VESVT 1293
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
L+ E + KL A ++Q+ + L EE +++ + K +L+ + + +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 247 DKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAG-KSTSPSHAVVA 305
++ R I + + K F A L G F ++ + + A
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDF-ASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 306 NVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ 365
L K + +D V++ + VS+ K +K I+ + ++
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 366 TLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQL 425
+ E + LA+ ++E+ +E K++LE + L ME + V K +L
Sbjct: 1473 RAEAEAREKETKALSLARALEEA--LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 426 EKQK--LEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDF-------MKLRPGEKRRK 476
EK K LE Q +E+K + L++E ++ + + N + ++ R + K
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 477 NLQLLKDMQSIQNSLQ 492
QL + + + L+
Sbjct: 1591 RRQLQRQLHEYETELE 1606
Score = 45.1 bits (105), Expect = 2e-04
Identities = 93/494 (18%), Positives = 189/494 (38%), Gaps = 61/494 (12%)
Query: 49 DLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVL 108
+++ S SK L S A+ K Q +I L + + + L + ++ L
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 109 DEQIQERENSKNEES--KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLE 166
D+ + + +N + S + Q QLLA E N+ K + A + T L
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALS 1487
Query: 167 K----QVSLERERQHDQTHVQSQLEKLDLLEQE------YNKLTTMQALAEKKMQELEAK 216
+ +LE + + ++T+ + E DL+ + ++L + E +M+E++ +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 217 LHEEEQERKRMQAKAAELQTGLETNRLIFE-DKATPCVPNARRIKKKKSK--------PP 267
L E E E + + L+ ++ + FE D N + ++ + +
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 268 EKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVI 327
E+K A+ L D+ A + + ++ + MK + L + R
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 328 -NSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAK--- 383
+ I + + + KS + + +L E L + Q + ++LA+
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLM---------QLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 384 --------LIQESPTVELK-DKLECELEALVGRMEAKANQITKVRKYQAQLE-------- 426
L E +E + +LE ELE G MEA ++++ K + QL
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 427 --------KQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNL 478
+Q+LE+Q KEL++ ++ S +S I K ++ + ++ R+
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 479 QLLKDMQSIQNSLQ 492
K ++ L+
Sbjct: 1839 AATKSLKQKDKKLK 1852
Score = 41.6 bits (96), Expect = 0.002
Identities = 80/398 (20%), Positives = 161/398 (40%), Gaps = 40/398 (10%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E + RA+ + ++ ++ ++ LE + +QA E K ++ K E+ + + +NEE
Sbjct: 1531 EKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 123 SKHNQELTSQLLAAENKCNLLEKQL-------EYMRNMIKHAEMERTSVLEKQVSLERER 175
+ ++L QL E + KQ + + +K E++ S ++ + ++
Sbjct: 1590 KR--RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 176 QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
+ Q ++ +L+ +++ EKK + LEA L + +++ A+ A Q
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED--LAAAERARKQ 1705
Query: 236 TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGK 295
LE L E ++ NA + +K++ + + Q G+M ++ +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ-------GNMEAMSDR 1758
Query: 296 STSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNG 355
A QL L + S A N+ A+Q R K + S
Sbjct: 1759 VRK---ATQQAEQLSNELATERSTAQKNES-------ARQQLERQNKELR-SKLHEMEGA 1807
Query: 356 INEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI 415
+ + + L+ + Q+ +Q A+ +++ T LK K + E L+ Q+
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILL--------QV 1858
Query: 416 TKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSR 453
RK A+ K++ EK +K K+ L+E S R
Sbjct: 1859 EDERK-MAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 60.1 bits (144), Expect = 5e-09
Identities = 104/455 (22%), Positives = 184/455 (40%), Gaps = 62/455 (13%)
Query: 79 KIRRLELERIQAE--ESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
K+ EL R + E + ++T RE E KV E+ Q ++E + + L + L
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 137 ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEY 196
+ K L E + + +R++ + AE RT +LE + SLE+ Q ++ + L+ + ++
Sbjct: 543 QKKAILTESENK-LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH 601
Query: 197 NKLTTMQALAEKKMQELEAKLHEE---------------EQERKRMQAKA-AELQTGLET 240
NK T+ + EK ELE+ H++ + E ++++ K E +T L+
Sbjct: 602 NKEITV--MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
Query: 241 NRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPS 300
+IF+ N + ++K K E +S + R L + V T
Sbjct: 660 KEIIFQAHIEEM--NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
Query: 301 HAVVA---------NVQLVLHLMKQH-------SKALCNDRVINSIPLA-----KQVSSR 339
+ + Q V ++K+H KAL + IN + L K +
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ--INQLELLLKERDKHLKEH 775
Query: 340 GGKSKKLSVTPPSSNGINEELSEVLQTLQD----EFGQMSFDHQQLAKLIQESPTVELKD 395
+ L S G ++ S L Q Q +QLA+L Q+ +E +
Sbjct: 776 QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETER 835
Query: 396 KLECELEALVGRMEAKANQI---TKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSS 452
L L V +EA+ + K Q Q Q+LEKQ E++ K+L + S
Sbjct: 836 IL---LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKL 892
Query: 453 RSGITGTTN------KKDFMKLRPGEKRRKNLQLL 481
G +K+ M L+ E ++K +++L
Sbjct: 893 EDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927
Score = 56.6 bits (135), Expect = 5e-08
Identities = 94/470 (20%), Positives = 192/470 (40%), Gaps = 70/470 (14%)
Query: 49 DLRRSPSKPTLAYPESNSRAIFSALKN----------LQDKIRRLEL----ERIQAEESV 94
+LR K A E +A+ +A K + ++I+ +E ERI ++ +
Sbjct: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQEL 459
Query: 95 KTLSRETIEY-KKVLDEQIQERENSKNEE-SKHNQELTSQLLAAENKCNLLEKQLEYMRN 152
+ +E ++ KK +EQI + + +E ++ QELT +L E E+
Sbjct: 460 SRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER---------EFQEQ 510
Query: 153 MIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEK---K 209
M E ++ L+ +S E+E+Q + +L+K +L + NKL +Q AE +
Sbjct: 511 MKVALEKSQSEYLK--ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
Query: 210 MQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEK 269
+ ELE+ L + QE K ++ +L LE + + T V +K K++
Sbjct: 569 ILELESSLEKSLQENKN---QSKDLAVHLEAEKNKHNKEITVMV------EKHKTELESL 619
Query: 270 KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINS 329
K ++ + K ++ + +Q + L D+ I
Sbjct: 620 KHQQDALWTE---------------KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 664
Query: 330 IPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESP 389
++++ + +KL V ++ ELSEVL+ ++S + +
Sbjct: 665 QAHIEEMNEK--TLEKLDVKQTELESLSSELSEVLKARHKLEEELS---------VLKDQ 713
Query: 390 TVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERN 449
T ++K +LE +++ + + + I K + Q ++ L+ Q +L+ K ER+
Sbjct: 714 TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK----ERD 769
Query: 450 SSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCWD 499
+ N + +K GE ++ + + L QS Q++ + ++
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAK-LDVFQSYQSATHEQTKAYE 818
Score = 53.9 bits (128), Expect = 3e-07
Identities = 94/443 (21%), Positives = 186/443 (41%), Gaps = 69/443 (15%)
Query: 62 PESNSRAIFS------ALKNLQDKIRRLE------LERIQA-EESVKTLSRETIEYKKVL 108
PES+ + L+ LQ +++R E E IQ+ +E L+ E ++ L
Sbjct: 264 PESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL 323
Query: 109 DEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQ-----LEYMRNMIKHAEMERTS 163
DE++QE E K+ +L +QL A+N LE+ E R M + EM+
Sbjct: 324 DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEE 383
Query: 164 VLE-----KQVSLERE--RQHDQTHVQSQLEKLD---------------LLEQEYNKLTT 201
+ + KQ++ + E R+ + ++ E+L+ L + ++ T
Sbjct: 384 IAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT 443
Query: 202 MQALAEKKMQELEAKLHEEEQE-----RKRMQAKAAELQTGLETNRLIFEDKATPCVPNA 256
++ +E++ L+ +L +QE +K + + A+LQ E E + T +
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503
Query: 257 RRIKKKKSKPPEKKSSRNYF----GAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLH 312
R +++ K +KS Y + L L ++ A++ + L
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL-------QKKAILTESENKLR 556
Query: 313 LMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSV-TPPSSNGINEELSEVLQTLQDEF 371
++Q ++ + L K + +SK L+V N N+E++ +++ + E
Sbjct: 557 DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL 616
Query: 372 GQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRK--YQAQLEK-- 427
S HQQ A ++ LK + + E+E L + E + + K ++ +QA +E+
Sbjct: 617 --ESLKHQQDALWTEKLQV--LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672
Query: 428 ----QKLEKQKKELKATKKTLDE 446
+KL+ ++ EL++ L E
Sbjct: 673 EKTLEKLDVKQTELESLSSELSE 695
Score = 51.2 bits (121), Expect = 2e-06
Identities = 102/483 (21%), Positives = 193/483 (39%), Gaps = 76/483 (15%)
Query: 12 SHLSNSFAEPSRSNGSMVRHSSSPYVVYPSDKPFLNSDLRRSPSKPTLAYPESNSRAIFS 71
+H+ N A+ RS G + + +S+ V+ S + + + T AY E
Sbjct: 777 AHVENLEADIKRSEGEL-QQASAKLDVFQS--------YQSATHEQTKAYEEQ------- 820
Query: 72 ALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTS 131
L LQ K+ LE ERI + V + + + LD + ++ + K N E+
Sbjct: 821 -LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ 879
Query: 132 QLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDL 191
++ ++ + E +LE + E E+T KQ+ +E+E Q + Q +++++
Sbjct: 880 KV---KSLTQVYESKLE-----DGNKEQEQT----KQILVEKENMILQMR-EGQKKEIEI 926
Query: 192 LEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATP 251
L Q KL+ + +E E K +E++ ++++ KA E+Q L+ L E K
Sbjct: 927 LTQ---KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 252 CVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVL 311
+ N +K K K AQ + AG S + S + +
Sbjct: 984 ELENTALELSQKEKQFNAKMLEM---AQAN----------SAGISDAVSRLETNQKEQIE 1030
Query: 312 HLMKQHSKALCNDRV----------------INSIPLAKQVSSRGGKSKKLSVTPPSSNG 355
L + H + L ND + I+ I L ++ +K+ +
Sbjct: 1031 SLTEVHRREL-NDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
Query: 356 INEELS----------EVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALV 405
+N+E++ L LQ++ Q S LA+ E+ +KLE +L +
Sbjct: 1090 MNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQ--DETKLKAHLEKLEVDLNKSL 1147
Query: 406 GRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDF 465
Q+ ++ K A+ +K+K+ + +LK T + ++S +S + +F
Sbjct: 1148 KENTFLQEQLVEL-KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF 1206
Query: 466 MKL 468
KL
Sbjct: 1207 KKL 1209
Score = 47.4 bits (111), Expect = 3e-05
Identities = 87/473 (18%), Positives = 182/473 (38%), Gaps = 71/473 (15%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E+ ++ + + L+D I + +E E +K +++ K L +++Q + E+
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHV 182
+E ++L EN+ ++ +LE + ++H + S E+ +LE + +
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAK 1636
Query: 183 QSQLE----------KLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAA 232
++L+ K LL Q K + E + EL KL E E+E ++ K
Sbjct: 1637 LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLK 1696
Query: 233 ELQTGLETNRLI-------------------------FEDKATPCVPNARRIKKKKSKPP 267
+++ ++ +E+K + N +K +
Sbjct: 1697 SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG 1756
Query: 268 EKKSS--RNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDR 325
++K ++F + Y+ L + K + ++ HL ++ L
Sbjct: 1757 QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE-------DQSMIGHLQEE----LEEKN 1805
Query: 326 VINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLI 385
S+ +A+ V GGK+ + + +V +TLQ++ Q++ +L
Sbjct: 1806 KKYSLIVAQHVEKEGGKN-----NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL- 1859
Query: 386 QESPTVELKDKLECELEALVGRME-AKANQITKVRKYQAQLEKQKLEKQKKELKATKKTL 444
+S V K+ E+E L + E +A Q R +L ++ E++ K K L
Sbjct: 1860 -DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL 1918
Query: 445 DEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNL-----QLLKDMQSIQNSLQ 492
S + N +F KL E+ ++ L +L KD++ ++ Q
Sbjct: 1919 ---------SNMEAQHNDLEF-KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Score = 41.6 bits (96), Expect = 0.002
Identities = 69/382 (18%), Positives = 159/382 (41%), Gaps = 65/382 (17%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
Q+K L+ + I + ++ ++ +T+E V +++ + +E K +L +L
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 137 ENKCNLLEKQLEYMRNMIK--HAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQ 194
+++ + ++++LE + K H + + + E +VS++R + ++ Q+ +L+LL +
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQR----TEKALKDQINQLELLLK 766
Query: 195 EYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVP 254
E +K ++E +A + E + KR + + + L+ +F+ +
Sbjct: 767 E----------RDKHLKEHQAHVENLEADIKRSEGELQQASAKLD----VFQSYQSATHE 812
Query: 255 NARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLM 314
+ +++ ++ +K + L + V + + A+ V LM
Sbjct: 813 QTKAYEEQLAQLQQK-----LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 315 KQHSKALCNDRVINSIPLAKQVSSRGGKSKKLS-VTPPSSNGINEELSEVLQTLQDEFGQ 373
+Q L KQ S K K L+ V N+E + Q L +
Sbjct: 868 QQ---------------LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE---- 908
Query: 374 MSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI--------TKVRKYQAQL 425
+E+ +++++ + E+E L ++ AK + I TK + + ++
Sbjct: 909 ------------KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKM 956
Query: 426 EKQKLEKQKKELKATKKTLDEE 447
EK K + ++ + KK LD+E
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQE 978
Score = 40.4 bits (93), Expect = 0.004
Identities = 43/209 (20%), Positives = 87/209 (41%), Gaps = 29/209 (13%)
Query: 69 IFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQE 128
+ +++L K+ L E+I A E V S + E+KK + + +N+ E +
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL 1469
Query: 129 LTSQLLAAENKCNLLEKQLEYMRNMIK----HAEMERTSVLEKQVSLERERQHDQTHVQS 184
+ + + + NLL+++L+ E +++ + +K+ +LE E + +
Sbjct: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME 1529
Query: 185 ----------QLEKLDLLEQEYN------------KLTTMQALAEKK---MQELEAKLHE 219
++E L+ + + YN KL Q L E+K ++E E K+
Sbjct: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
Query: 220 EEQERKRMQAKAAELQTGLETNRLIFEDK 248
E + M+A+ + LE L + K
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSK 1618
Score = 39.3 bits (90), Expect = 0.008
Identities = 41/195 (21%), Positives = 84/195 (43%), Gaps = 19/195 (9%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE-----SKHNQ 127
L++L ++ + R + EE + L +T + K+ L+ ++ E++N ++ +H
Sbjct: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 745
Query: 128 ELTSQLLAAENKCNLLEKQLEYMRNMIK----HAEMERTSVLEKQVSLER--------ER 175
+ A +++ N LE L+ +K H E + + L++ +
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805
Query: 176 QHDQTHVQSQL--EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
TH Q++ E+L L+Q+ L T + L K++ E+EA+ + E + + +
Sbjct: 806 YQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQD 865
Query: 234 LQTGLETNRLIFEDK 248
L LE E K
Sbjct: 866 LMQQLEKQNSEMEQK 880
Score = 38.1 bits (87), Expect = 0.019
Identities = 94/510 (18%), Positives = 196/510 (38%), Gaps = 73/510 (14%)
Query: 21 PSRSNGSMVRHSSSPYVVYPSDKPFLNSDLR----RSPSKPTLAYPES----------NS 66
P+R +G + + PS + S ++ RS SK +L S +S
Sbjct: 51 PNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSS 110
Query: 67 RAIFSALKNLQDKIRRL-----ELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNE 121
A F ++ + L L + Q + ++ + R Y+ E + + + E
Sbjct: 111 TASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE 170
Query: 122 ESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEME----------RTSVLEKQVSL 171
+ K L+ + + L ++L+ + KH + E SVL+ QVSL
Sbjct: 171 KKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSL 230
Query: 172 ERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQ------------ALAEKKMQELEAKLHE 219
++R + L+ L LE + T + + K ++ L+ ++
Sbjct: 231 LKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKR 290
Query: 220 EEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQ 279
+E KR + +Q+ E L+ +K R+++ + + + Q
Sbjct: 291 QENLLKRCKET---IQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQ 347
Query: 280 PHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHL---MKQHSKALCNDRVINSIPLAKQV 336
L D + + V+A + +H MK+ A R+ KQ+
Sbjct: 348 ------LRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRI-------KQM 394
Query: 337 SSRGGKSKKLSVTPPSSNGINEELSEVLQTLQ---DEFGQMSFDHQQLAKLIQ---ESPT 390
+++G + ++ S EEL + L T Q + ++ + + K I+ E
Sbjct: 395 TTQGEELREQK--EKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEER 452
Query: 391 VELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNS 450
+ L+ +L + +V M+ + + ++ K Q EK E +KE + TKK ER
Sbjct: 453 ISLQQELSRVKQEVVDVMKKSSEE--QIAKLQKLHEK---ELARKEQELTKKLQTREREF 507
Query: 451 SSRSGITGTTNKKDFMKLRPGEKRRKNLQL 480
+ + ++ +++K+ ++++++L L
Sbjct: 508 QEQMKVALEKSQSEYLKISQEKEQQESLAL 537
Score = 37.4 bits (85), Expect = 0.032
Identities = 92/429 (21%), Positives = 155/429 (36%), Gaps = 95/429 (22%)
Query: 77 QDKIR-RLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLA 135
QD+ + + LE+++ + + K+L T L EQ+ E + E+ + ELTS+L
Sbjct: 1127 QDETKLKAHLEKLEVDLN-KSLKENTF-----LQEQLVELKMLAEEDKRKVSELTSKLKT 1180
Query: 136 AENK------------------------------------CNLLEKQLEYMRNMIKHAEM 159
+ + C E LE N + +
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1240
Query: 160 ERTSVLEKQVSLERERQHDQTHVQSQLE----KLDLLEQEYNKLTTMQALAEKKMQELEA 215
+T+ + ++S QH T V+ L + LE + +LT Q Q+
Sbjct: 1241 SKTNAILSRIS---HCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATH 1297
Query: 216 KLHEEEQERKRMQAKAAELQTGLET------NRLIFEDKATPCV--------PNARRIKK 261
+L E+E + K M+A L T E N+ + C+ N +
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
Query: 262 KKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKAL 321
K + EKK + Q L D+ S S S A + L KQ+ +
Sbjct: 1358 MKEELKEKKVEISSLSKQ------LTDLNVQLQNSISLSEKEAA----ISSLRKQYDEEK 1407
Query: 322 CNDRVINSIPLAKQVSSRGGKSKKLSVTPPSS----NGINEELSEVLQTLQDEFGQMSFD 377
C L QV K LS S+ + + + SE + Q F Q
Sbjct: 1408 CE--------LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQ---- 1455
Query: 378 HQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITK---VRKYQAQLEKQKLEKQK 434
HQ K +Q +ELK K E + + ++ + +Q K K + + +K K+EK++
Sbjct: 1456 HQNTVKELQIQ--LELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE 1513
Query: 435 KELKATKKT 443
L+ K+
Sbjct: 1514 SNLETELKS 1522
Score = 30.0 bits (66), Expect = 5.1
Identities = 32/140 (22%), Positives = 62/140 (44%), Gaps = 8/140 (5%)
Query: 97 LSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLL--AAENKCNLLEKQLEYMRNMI 154
L+++ E + + E I + + + E + +QE T+QLL AE +L Y +
Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILD 2064
Query: 155 KHAEMERTSVLEKQVSLER-ERQHDQTHVQSQLEKLD-----LLEQEYNKLTTMQALAEK 208
E V + Q LE ++++ Q Q + D L+ + + TT+ + ++
Sbjct: 2065 AREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKL 2124
Query: 209 KMQELEAKLHEEEQERKRMQ 228
K QE ++H E K+ +
Sbjct: 2125 KEQEFREQIHNLEDRLKKYE 2144
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 59.7 bits (143), Expect = 6e-09
Identities = 81/380 (21%), Positives = 152/380 (40%), Gaps = 72/380 (18%)
Query: 87 RIQAEESVKTLSRETIEY----KKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNL 142
++QAE+ E E+ K L+ +++E EE + N ELT++ E++C
Sbjct: 902 QLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFE 961
Query: 143 LEKQLEYMRNMIKHAEMERTSV-------------LEKQVS-LERERQHDQTHVQSQLEK 188
L+K+++ + M+ +E E+ + L + +S L R + Q Q L+
Sbjct: 962 LKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD 1021
Query: 189 LDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDK 248
L + E++ + L+ E+++ ELE L +E + R + + +L+ L+ NR E+
Sbjct: 1022 LHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENL 1081
Query: 249 ATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQ 308
+ A ++KK+ + + S +VA +Q
Sbjct: 1082 ESSQRHLAEELRKKELELSQMNS------------------------KVENEKGLVAQLQ 1117
Query: 309 LVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEV----- 363
+ ++ K L AK R ++ L+ +NE L EV
Sbjct: 1118 KTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLA-------DLNERLEEVGGSSL 1170
Query: 364 -----LQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKV 418
+ + +F ++ D ++ A L E+ + LK + L L G++E
Sbjct: 1171 AQLEITKKQETKFQKLHRDMEE-ATLHFETTSASLKKRHADSLAELEGQVE--------- 1220
Query: 419 RKYQAQLEKQKLEKQKKELK 438
Q KQKLEK K +L+
Sbjct: 1221 ---NLQQVKQKLEKDKSDLQ 1237
Score = 41.6 bits (96), Expect = 0.002
Identities = 104/446 (23%), Positives = 178/446 (39%), Gaps = 76/446 (17%)
Query: 65 NSRAIFSALKN-----LQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSK 119
N RA F A+KN L KI+ L ++ + E V L E + +K L++ +RE K
Sbjct: 829 NIRA-FMAVKNWPWMRLFFKIKPL-VKSSEVGEEVAGLKEECAQLQKALEKSEFQREELK 886
Query: 120 NEESKHNQE---LTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQ 176
++ QE L QL A + +E+Q E++ ++ LE +V ER
Sbjct: 887 AKQVSLTQEKNDLILQLQAEQETLANVEEQCEWL--------IKSKIQLEARVKELSERV 938
Query: 177 HDQTHVQSQLEKLDL-LEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
++ + S+L LE E +L +K++ +LE L + E+E++ + K L
Sbjct: 939 EEEEEINSELTARGRKLEDECFEL-------KKEIDDLETMLVKSEKEKRTTEHKVKNLT 991
Query: 236 TGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGK 295
+E + ED + K +R Q ++ L D+ K
Sbjct: 992 EEVE---FLNEDIS--------------------KLNRAAKVVQEAHQQTLDDLHMEEEK 1028
Query: 296 STSPSHAVVANVQLVLHL---MKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPS 352
+S S A + Q V L ++Q KA N +++ G K + +
Sbjct: 1029 LSSLSKANLKLEQQVDELEGALEQERKARMN--------CERELHKLEGNLKLNRESMEN 1080
Query: 353 SNGINEELSEVLQTLQDEFGQMSFDHQ-------QLAKLIQESPT--VELKDKLECELEA 403
L+E L+ + E QM+ + QL K ++E T +LK+KLE E
Sbjct: 1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTT 1140
Query: 404 LVGRMEAKANQITKVRKYQAQLEK------QKLE-KQKKELKATKKTLDEERNSSSRSGI 456
+A+ + +LE+ +LE +K+E K K D E +
Sbjct: 1141 RAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETT 1200
Query: 457 TGTTNKKDFMKLRPGEKRRKNLQLLK 482
+ + K+ L E + +NLQ +K
Sbjct: 1201 SASLKKRHADSLAELEGQVENLQQVK 1226
Score = 41.6 bits (96), Expect = 0.002
Identities = 61/257 (23%), Positives = 116/257 (45%), Gaps = 36/257 (14%)
Query: 42 DKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQ------DKIRRL-ELERIQAEESV 94
D LNSDL K +A E + + S L++L+ ++ RRL E E ++A E +
Sbjct: 1671 DSTQLNSDL-----KEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERI 1725
Query: 95 --------------KTLSRETIEYKKVLDEQIQERENSKNEESKHNQE---LTSQLLAAE 137
K L + +K +E +QE +N++ + K E L+ +L +
Sbjct: 1726 NLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQ 1785
Query: 138 NKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLD-LLEQEY 196
+ LE+ E M I ++++ +Q++L R+ Q ++S++ +L+ LE E
Sbjct: 1786 DTIAHLERTRENMEQTI--TDLQKRLAEAEQMALMGSRKQIQK-LESRVRELEGELEGEI 1842
Query: 197 NKLTTMQALA---EKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCV 253
+ Q A E+ ++EL + E+++ RMQ + +LQ ++ + E T
Sbjct: 1843 RRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQAN 1902
Query: 254 PNARRIKKKKSKPPEKK 270
+ KK++ + E K
Sbjct: 1903 QYLSKYKKQQHELNEVK 1919
Score = 40.8 bits (94), Expect = 0.003
Identities = 85/390 (21%), Positives = 156/390 (40%), Gaps = 50/390 (12%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
KNLQ++I L Q E K L+ E + KK+++E+ E + + E ++
Sbjct: 1515 KNLQEEISNLTN---QVREGTKNLT-EMEKVKKLIEEEKTEVQVTLEE---------TEG 1561
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
N+ +L QLE + AE+ER + EK +E R+ Q + S LD
Sbjct: 1562 ALERNESKILHFQLELLE---AKAELER-KLSEKDEEIENFRRKQQCTIDSLQSSLDSEA 1617
Query: 194 QEYNKLTTMQALAEKKMQELEAKL-------HEEEQERKRMQAKAAELQTGLETNRLIFE 246
+ ++T ++ E+ + E+E +L E + ++Q + +LQ L+ + +
Sbjct: 1618 KSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS 1677
Query: 247 D-KATPCVPNAR-----------RIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAG 294
D K V R R +++++ + S A L +
Sbjct: 1678 DLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLS 1737
Query: 295 KSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSN 354
+ A VA +Q + Q C + + A + ++ + KK T
Sbjct: 1738 QK-KKLEADVARMQKEAEEVVQE----CQNAEEKAKKAAIEAANLSEELKKKQDTIAHLE 1792
Query: 355 GINEELSEVLQTLQD---EFGQMSF--DHQQLAKLIQESPTVELKDKLECEL--EALVGR 407
E + + + LQ E QM+ +Q+ KL ES EL+ +LE E+ A R
Sbjct: 1793 RTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKL--ESRVRELEGELEGEIRRSAEAQR 1850
Query: 408 MEAKANQITKVRKYQAQLEKQKLEKQKKEL 437
+ + K YQA+ +K+ L + + ++
Sbjct: 1851 GARRLERCIKELTYQAEEDKKNLSRMQTQM 1880
Score = 38.1 bits (87), Expect = 0.019
Identities = 87/441 (19%), Positives = 180/441 (40%), Gaps = 60/441 (13%)
Query: 80 IRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENK 139
+RRLE + E + LSRE + + QI++ +E+K L L A+
Sbjct: 1300 LRRLE----EKEALINQLSREKSNFTR----QIEDLRGQLEKETKSQSALAHALQKAQRD 1351
Query: 140 CNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKL 199
C+LL +Q E + + AE+ RT +V+ E Q + + +++ + LE +L
Sbjct: 1352 CDLLREQYEEEQEV--KAELHRTL---SKVNAEMV-QWRMKYENNVIQRTEDLEDAKKEL 1405
Query: 200 TTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRI 259
A + M A+ E+ R ++Q + + + L R + + + +
Sbjct: 1406 AIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKAL 1465
Query: 260 KKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSK 319
K K E ++ + +Q + ++ + K+T V +++ +K
Sbjct: 1466 ADWKQKHEESQALLD--ASQKEVQALSTEL--LKLKNTYEESIVGQET------LRRENK 1515
Query: 320 ALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQ 379
L + + N L QV R G +K L+ I EE +EV TL++ G + +
Sbjct: 1516 NL-QEEISN---LTNQV--REG-TKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNES 1568
Query: 380 QL---------------AKLIQESPTVE-LKDKLECELEALVGRMEAKANQITKVRKYQA 423
++ KL ++ +E + K +C +++L ++++A +V + +
Sbjct: 1569 KILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKK 1628
Query: 424 QLEKQKLEKQKKELKATKKTLDEERNSSSRSGI---------TGTTNKKDFMKLRPGEKR 474
++E + L + + +L + + E S + I +T +K +
Sbjct: 1629 KME-EDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAE 1687
Query: 475 RKNLQL---LKDMQSIQNSLQ 492
R+N L L+D++S+Q +
Sbjct: 1688 RRNSLLQSELEDLRSLQEQTE 1708
Score = 32.7 bits (73), Expect = 0.79
Identities = 41/203 (20%), Positives = 81/203 (39%), Gaps = 39/203 (19%)
Query: 71 SALKNLQDKIRRLELER--------------IQAEESVKTLSRETIEYKKVLDEQIQERE 116
S+ ++L +++R+ ELE Q +++VK L + + K+ L+ + R
Sbjct: 1083 SSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRA 1142
Query: 117 NSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK-----HAEMERTSVLEKQVSL 171
+ E + Q+L E QLE + H +ME ++ + S
Sbjct: 1143 KMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSA 1202
Query: 172 ERERQHDQT--HVQSQLEKLDLLEQEYNK------------------LTTMQALAEKKMQ 211
+++H + ++ Q+E L ++Q+ K +T +A AEK
Sbjct: 1203 SLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCT 1262
Query: 212 ELEAKLHEEEQERKRMQAKAAEL 234
E +LHE + ++ A +L
Sbjct: 1263 LYEERLHEATAKLDKVTQLANDL 1285
Score = 29.6 bits (65), Expect = 6.7
Identities = 75/391 (19%), Positives = 151/391 (38%), Gaps = 48/391 (12%)
Query: 77 QDKIRRLELER-IQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLA 135
Q++ R+ ER + E L+RE++E + + E E K EL+
Sbjct: 1052 QERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAE------ELRKKELELSQMNSK 1105
Query: 136 AENKCNL---LEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLL 192
EN+ L L+K ++ ++ IK + + + + +ERER + L L+
Sbjct: 1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERER----ADLTQDLADLNER 1161
Query: 193 EQEYNKLTTMQALAEKKMQELEAKLHEE-EQERKRMQAKAAELQTGLETNRLIFEDKATP 251
+E + Q KK + KLH + E+ + +A L+ + E +
Sbjct: 1162 LEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQ--- 1218
Query: 252 CVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVL 311
V N +++K+K K + +L + D+ + T AN + +
Sbjct: 1219 -VENLQQVKQKLEKD------------KSDLQLEVDDLLTRVEQMTRAK----ANAEKLC 1261
Query: 312 HLMKQ--HSKALCNDRVIN-----SIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVL 364
L ++ H D+V + K S G ++L N ++ E S
Sbjct: 1262 TLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFT 1321
Query: 365 QTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECEL--EALVGRMEAKANQITKVRKYQ 422
+ ++D GQ+ + + + L K + +C+L E E KA + K
Sbjct: 1322 RQIEDLRGQLEKETKSQSALAHALQ----KAQRDCDLLREQYEEEQEVKAELHRTLSKVN 1377
Query: 423 AQLEKQKLEKQKKELKATKKTLDEERNSSSR 453
A++ + +++ + ++ T+ D ++ + R
Sbjct: 1378 AEMVQWRMKYENNVIQRTEDLEDAKKELAIR 1408
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 59.7 bits (143), Expect = 6e-09
Identities = 104/527 (19%), Positives = 221/527 (41%), Gaps = 92/527 (17%)
Query: 55 SKPTLAYPESNSRAIFSALKNL--QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQI 112
+K LA+ +SR L+ +++ + EL+R ++ + + T +Y+ ++
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRT-KYETDAIQRT 1387
Query: 113 QERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHA--EMERTSV----LE 166
+E E +K + ++ Q+ + A KC LEK + ++N ++ ++ERT+ L+
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD 1447
Query: 167 KQ------VSLERERQHDQTHVQ---SQLEKLDL----------LEQEYNKLTTMQALAE 207
K+ + E +++ ++TH + SQ E L E+ ++L T++ +
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENK 1507
Query: 208 KKMQELE----------AKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNAR 257
QE+ ++HE E+ +K+++ + +ELQ LE E + +
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQL 1567
Query: 258 RIKKKKSKPPEKKSSRNYFGAQ---PHYRLCLGDMPFVAGKSTSPSHAVVANVQL----- 309
+ + KS+ K + ++ Q H R+ + + S + A+ ++
Sbjct: 1568 ELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627
Query: 310 -----VLHLMKQHSKALCNDRVINSI------PLAKQVSSRGGKSKKLSVTPPSSNGINE 358
+ H + ++AL N R +I L + S+ ++L++ +N +
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687
Query: 359 ELSEVLQTLQDEFGQMSFDHQQLAKL--------IQESPTVELKDKLECELEALVGRM-- 408
E+ E+ TL+ Q+L Q + + K KLE ++ + G M
Sbjct: 1688 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED 1747
Query: 409 --------EAKANQ-ITKVRKYQAQLEKQK-----LEKQKKELKATKKTLDEERNSSSRS 454
E KA + IT +L+K++ LE+ KK L+ T K L + + +
Sbjct: 1748 IIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 455 GITGTTNKKDFMKLR------PGE---KRRKNLQLLKDMQSIQNSLQ 492
+ G KK KL GE ++++N++ +K ++ + ++
Sbjct: 1808 ALKG--GKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVK 1852
Score = 58.9 bits (141), Expect = 1e-08
Identities = 98/478 (20%), Positives = 189/478 (39%), Gaps = 61/478 (12%)
Query: 41 SDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRE 100
++K N +K LA E+ + + + L + L+L+ +QAE + E
Sbjct: 849 TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ-VQAEADSLADAEE 907
Query: 101 T----IEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM------ 150
I+ K L+ +I+E +E + N ELT++ E++C+ L+K ++ +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 151 --------RNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTM 202
N +K+ E + E L +E++ Q Q L+ L E + N LT
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027
Query: 203 QALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKK 262
+ E+++ +LE L +E++ R ++ +L+ L+ ++T + N ++ +
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK-----LAQESTMDIENDKQQLDE 1082
Query: 263 KSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALC 322
K K E + S G Q A+ +Q + ++ + L
Sbjct: 1083 KLKKKEFEMS----GLQ---------------SKIEDEQALGMQLQKKIKELQARIEELE 1123
Query: 323 NDRVINSIPLAKQVSSRGGKSKKL---SVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQ 379
+ AK R S++L S + G E+ + + EF +M D +
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 380 QLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKA 439
+ A L E+ L+ K + L QI +++ KQKLEK+K E+K
Sbjct: 1184 E-ATLQHEATAATLRKKHADSVAEL-------GEQIDNLQRV-----KQKLEKEKSEMKM 1230
Query: 440 TKKTL--DEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSS 495
L + E S ++ + + K + +L+ D+ + + LQ+ S
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTES 1288
Score = 53.5 bits (127), Expect = 4e-07
Identities = 106/483 (21%), Positives = 192/483 (39%), Gaps = 64/483 (13%)
Query: 58 TLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQEREN 117
TLA E A + +KNL +++ L+ E++ L++E KK L E Q+ +
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLD-------ETIAKLTKE----KKALQEAHQQTLD 1012
Query: 118 SKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQH 177
E LT + E + + LE LE + + E + LE + L +E
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRK-LEGDLKLAQESTM 1071
Query: 178 DQTHVQSQL-EKLDLLEQEYN----KLTTMQALA---EKKMQELEAKLHEEEQE------ 223
D + + QL EKL E E + K+ QAL +KK++EL+A++ E E+E
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131
Query: 224 -RKRMQAKAAELQTGLE--TNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQP 280
R + + + ++L LE + RL AT +A+ KK + +K R+ A
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGAT----SAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 281 HYRLCLGDMPFVAGKSTSPSHAVVANVQLV---LHLMKQHSKALCNDRVINSIPLAKQVS 337
+ + S + + N+Q V L K K +D N ++K
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247
Query: 338 SRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTV------ 391
+ + L EE ++ L + ++ + + ++ + E T+
Sbjct: 1248 NLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307
Query: 392 ----------ELKDKLECELE---ALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELK 438
ELK +LE E++ AL +++ + +R+ + ++ K E Q+ K
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
Query: 439 ATKKTLD----EERNSSSRSGITGTTNKKDFMKLRPGEK-----RRKNLQLLKDMQSIQN 489
A + E ++ R+ KK +L+ E+ K L K Q +QN
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 490 SLQ 492
++
Sbjct: 1428 EVE 1430
Score = 45.8 bits (107), Expect = 9e-05
Identities = 75/413 (18%), Positives = 154/413 (37%), Gaps = 68/413 (16%)
Query: 64 SNSRAIFSALKNLQDKIRRLE--LERIQAEESVKT------------LSRETIEYKKVLD 109
SN + A NL+ R LE L I+ +E + L E+ EY + LD
Sbjct: 1237 SNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLD 1296
Query: 110 E-----------------QIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRN 152
E QI+E + EE K L L ++ + C+LL +Q E
Sbjct: 1297 EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE---- 1352
Query: 153 MIKHAEMERTSVLEKQVSLERER--QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKM 210
E E + L++ +S Q + +++ + LE+ KL AE+ +
Sbjct: 1353 ----EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408
Query: 211 QELEAKLHEEEQERKRMQAKAAELQTGLETNRL--------------IFEDKATPCVPNA 256
+ + AK E+ ++R+Q + +L +E I + C
Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKC--EE 1466
Query: 257 RRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAV------VANVQLV 310
+ + S+ + S F + Y L + + ++ + + +A
Sbjct: 1467 THAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1526
Query: 311 LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDE 370
+H +++ K + ++ L + +S + K+ N + E+ + +E
Sbjct: 1527 IHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586
Query: 371 FGQMSFDHQQLAKLIQESPTVELKD-----KLECELEALVGRMEAKANQITKV 418
QM +H ++ + +Q + E++ +L+ ++E + ME + N ++
Sbjct: 1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1639
Score = 42.0 bits (97), Expect = 0.001
Identities = 75/381 (19%), Positives = 157/381 (41%), Gaps = 57/381 (14%)
Query: 100 ETIEYKKVLDEQIQERENSKNEESK---HNQELTSQLLAAENKCNLLEKQLEYMRNMIKH 156
++ E +K + +E E +K E +K +EL +++ + N L+ Q++ + +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 157 AEMERTSVLEKQVSLER------ERQHDQTHVQSQLE-KLDLLEQEYNKLTTMQALAEKK 209
AE +++ ++ LE ER D+ + ++L K LE E ++L +K
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL-------KKD 957
Query: 210 MQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEK 269
+ +LE L + E+E+ + K L E+ A A+ K+KK+
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLT----------EEMAGLDETIAKLTKEKKA----- 1002
Query: 270 KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINS 329
Q ++ L D+ K + + A + Q V D + S
Sbjct: 1003 --------LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV-------------DDLEGS 1041
Query: 330 IPLAKQVSSRGGKSK-KLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQES 388
+ K++ ++K KL + ++ Q L ++ + F+ L I++
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101
Query: 389 PTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEER 448
+ + +L+ +++ L R+E +I R +A+ EKQ+ + +EL+ + L+E
Sbjct: 1102 QALGM--QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAG 1158
Query: 449 NSSSRSGITGTTNKKDFMKLR 469
++S + +F K+R
Sbjct: 1159 GATSAQIEMNKKREAEFQKMR 1179
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 59.7 bits (143), Expect = 6e-09
Identities = 90/432 (20%), Positives = 190/432 (43%), Gaps = 54/432 (12%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E + + + ++ L+ K+ ++E E + + ++ T +++ + +E +++ NS E
Sbjct: 633 EKERQRLVTGIEELRTKLIQIEAENSDLKVN---MAHRTSQFQLIQEELLEKASNSSKLE 689
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHV 182
S+ ++ SQLL E + L EK + Y K+AE+E+ ++EK + +T++
Sbjct: 690 SEMTKKC-SQLLTLEKQ--LEEKIVAYSSIAAKNAELEQ-ELMEKNEKIRSL----ETNI 741
Query: 183 QSQLEKLDLLEQEYNKLTTMQALA-EKKMQELEAKLHEEEQERKRMQAKAAELQTGLETN 241
++ EK+ L ++ K+ Q EK+++ LEA+L +++Q+ K + + LQ +
Sbjct: 742 NTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICK 801
Query: 242 RLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSH 301
+ E + +KK+ K E + ++ ++ D S
Sbjct: 802 QHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLD-----------SA 850
Query: 302 AVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGK----SKKLSVTPPSSNGIN 357
+ +LVLHL N N KQ+ + + K+L + S +
Sbjct: 851 LEICKEELVLHL---------NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETS 901
Query: 358 EELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELK-DKLECELEALVGRMEAKANQIT 416
E+ + TLQ + + + + +L +E + KLE EL+ + E+ A ++
Sbjct: 902 EQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK---QRESSAEKLR 958
Query: 417 KVRK------YQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKL-R 469
K+ + ++A L++QK+ + + K +D+ + S+ +K+ M L R
Sbjct: 959 KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKM-------EKEIMHLKR 1011
Query: 470 PGEKRRKNLQLL 481
GE + +L L
Sbjct: 1012 DGENKAMHLSQL 1023
Score = 42.4 bits (98), Expect = 0.001
Identities = 82/400 (20%), Positives = 153/400 (38%), Gaps = 57/400 (14%)
Query: 65 NSRAIFSALKNLQDKIRRLELERIQAEESV------------KTLSRETIEYKKVLD--- 109
N+ + A + + K+ +LE++QAEE + K L YK L+
Sbjct: 362 NAEELSKAFQQYKKKVAE-KLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILK 420
Query: 110 ---EQIQERENSKNEESK----HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERT 162
Q++E N+ E+ + N E+ +QL + LE +LE +
Sbjct: 421 EKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE-----------NKD 469
Query: 163 SVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQ 222
+L + SL E + + V +Q E+LDL +QE EK + +L K +
Sbjct: 470 EILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK-----R 524
Query: 223 ERKRMQAKAAELQTGLETNRLIFEDKATPC------VPNARRIKKKKSKPPEKKSSRNYF 276
E ++ ++ Q +N+ ED+ C V + RIK + +K N
Sbjct: 525 ELFGFKSYLSKYQMSSFSNK---EDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT 581
Query: 277 GAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQV 336
Q L + + +S+ S V+L H + + K + +Q
Sbjct: 582 ANQLSQSLITCN---DSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQR 638
Query: 337 SSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDK 396
G + + + I E S++ + Q ++L + S +E +
Sbjct: 639 LVTGIEELRTKLIQ-----IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMT 693
Query: 397 LEC-ELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKK 435
+C +L L ++E K + + A+LE++ +EK +K
Sbjct: 694 KKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEK 733
Score = 42.0 bits (97), Expect = 0.001
Identities = 45/183 (24%), Positives = 76/183 (41%), Gaps = 11/183 (6%)
Query: 64 SNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEES 123
+ SRA S L++ Q + + + EE + L E KVL +E EN +
Sbjct: 267 TQSRAKVSMLESAQQQAASVPI----LEEQIINLEAEVSAQDKVL----REAENKLEQSQ 318
Query: 124 KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQ 183
K E L ++ +C L+ L K AE +R L L + Q + V
Sbjct: 319 KMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVA 378
Query: 184 SQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQE--RKRMQAKAAELQTGLETN 241
+LEK+ E+ + T K++QE L++ E E +++++ E G E
Sbjct: 379 EKLEKVQAEEEILERNLTNCEKENKRLQE-RCGLYKSELEILKEKLRQLKEENNNGKEKL 437
Query: 242 RLI 244
R++
Sbjct: 438 RIM 440
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/207 (21%), Positives = 98/207 (47%), Gaps = 8/207 (3%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQ 132
L+ L+D +++ +L + ++K L+ E E K ++++ QE + N EL +
Sbjct: 1083 LQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQR 1142
Query: 133 LLAAEN-KCNLLEKQLEYMRNMIK-HAEMERTSVLEKQVSLERERQHDQT-HVQSQLEKL 189
+ + E + E + +IK +E++ + K+ + + E +D+ + + QL +
Sbjct: 1143 AAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREK 1202
Query: 190 DLL----EQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIF 245
+ + EQE ++L +++M+E+E+ + E+EQ +A +L L R
Sbjct: 1203 EFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQV 1262
Query: 246 EDKATPCVPNARRIKKKKSKPPEKKSS 272
++ T + AR + + + E+ SS
Sbjct: 1263 QNSHTE-LAEARHQQVQAQREIERLSS 1288
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/204 (22%), Positives = 86/204 (42%), Gaps = 11/204 (5%)
Query: 77 QDKIRRLELERIQA--EESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQ------- 127
Q+ IR ELE Q E+ V L +E + ++ E++++ E K E + H
Sbjct: 920 QETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEE-KCESAAHEADLKRQKV 978
Query: 128 -ELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQL 186
ELT + + + +++L M I H + + + L+ +T ++ +
Sbjct: 979 IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFE 246
+ LE+ + T A +K + LE +L E K + EL+ L+ +L E
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 247 DKATPCVPNARRIKKKKSKPPEKK 270
+K T +++ K + +KK
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKK 1122
Score = 40.0 bits (92), Expect = 0.005
Identities = 82/399 (20%), Positives = 151/399 (37%), Gaps = 67/399 (16%)
Query: 82 RLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL-------- 133
+ ELE+ +VK L + + L E +Q+RE + E + EL S L
Sbjct: 1031 KTELEK--KTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRD 1088
Query: 134 ------LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLE 187
L+ E K ++ +R E ++ +LE +L +ER + +Q+
Sbjct: 1089 VLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL-KERNWELKQRAAQVT 1147
Query: 188 KLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFED 247
LD+ +E+ + E+K+ +LE L + E E K + L L+ + +
Sbjct: 1148 HLDMTIREH------RGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLRE 1201
Query: 248 KATPCVPNARRI-----------KKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
K + N + I ++ K K Y Q + LG + +
Sbjct: 1202 KEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ 1261
Query: 297 TSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGI 356
SH +A + H Q + + +R+ + + KQ+S
Sbjct: 1262 VQNSHTELAEAR---HQQVQAQREI--ERLSSELEDMKQLS------------------- 1297
Query: 357 NEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEAL--VGRMEAKANQ 414
+E L +E G L +Q E+K KL E+E+L ME ++Q
Sbjct: 1298 -KEKDAHGNHLAEELGASKVREAHLEARMQ----AEIK-KLSAEVESLKEAYHMEMISHQ 1351
Query: 415 ITKVR-KYQAQLEKQKLEKQKKELKATKKTLDEERNSSS 452
+ K A +K +++ ++L+ K L+E +++ S
Sbjct: 1352 ENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVS 1390
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 59.3 bits (142), Expect = 8e-09
Identities = 42/167 (25%), Positives = 80/167 (47%), Gaps = 10/167 (5%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
++K+RR E + EE ++ L + E +K+ +++ + +E K E + QE +++
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 435
Query: 137 ENKCN-----LLEKQLEYMRNMIKHAEMERTSVLEKQVSLER-----ERQHDQTHVQSQL 186
E K + E++ + R K E E+ EK+ E E+ H+Q + Q
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 187 EKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
EK+ E++ K E+K++E E K+ E+E++ R + K E
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/152 (23%), Positives = 70/152 (46%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
++KIR E + + EE + + E +++ E+ + E K E + QE ++
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575
Query: 137 ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEY 196
E K E+++ I+ E +R EK E + + + +Q Q EK+ E++
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 197 NKLTTMQALAEKKMQELEAKLHEEEQERKRMQ 228
+ M E+KM E E K+ E+E++ + +
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 667
Score = 49.3 bits (116), Expect = 8e-06
Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 19/166 (11%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQ---IQERENSKNEESKHNQELTSQL 133
++KIR E +R + EE + + E ++ + EQ I+E+E E+ + QE ++
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649
Query: 134 LAAENK-CNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLL 192
E K C EK E M + E R EK++ + E+ +Q + + E+ +
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQ--EKKIREQEEKIREQEEMMQEQEE-KMW 706
Query: 193 EQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL 238
EQE +KM E E K+ E+E++ +R + K E + L
Sbjct: 707 EQE------------EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Score = 47.0 bits (110), Expect = 4e-05
Identities = 54/227 (23%), Positives = 100/227 (44%), Gaps = 21/227 (9%)
Query: 63 ESNSRAIFSALKNLQDKIRRLEL----ERIQAEESVKTLSRETIEYKKVLDEQIQERE-- 116
ES I +K L+ K+ R +L +++QAE L +E L Q++E E
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD--HLGKELQSVSAKLQAQVEENELW 291
Query: 117 ---NSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAE----MERTSVLEKQV 169
N + EE QE ++ E K E+++ I+ E + + EK+
Sbjct: 292 NRLNQQQEEKMWRQE--EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 170 SLERERQ---HDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKR 226
+ R+ + + ++ Q E + E++ + M E+K++ELE K+HE+E+ R++
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 409
Query: 227 MQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSR 273
+ + E + + R E K R +++K + EKK R
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE-QEEKIREQEKKMWR 455
Score = 45.8 bits (107), Expect = 9e-05
Identities = 34/154 (22%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
++KIR E + + EE + RE E ++ +E++ ++E E+ + QE ++
Sbjct: 576 EEKIREQEEKVWRQEEKI----REQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQ 631
Query: 137 ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEY 196
E K E+ + + E + EK E + ++ Q +K+ E++
Sbjct: 632 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691
Query: 197 NKLTTMQALAEKKMQELEAKLHEEEQERKRMQAK 230
+ M E+KM E E K+ E+E++ + + K
Sbjct: 692 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 725
Score = 43.5 bits (101), Expect = 4e-04
Identities = 39/197 (19%), Positives = 89/197 (45%), Gaps = 6/197 (3%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVL---DEQIQERENSKNEESKHNQELTSQL 133
++KIR+ E + + EE ++ + E ++ + +E+I+E+E EE K +++ +
Sbjct: 502 EEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ---EK 558
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
+ E K E ++ I+ E + EK E +RQ + + Q EK+ E
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCV 253
++ + E+K++E E E+E++ + K E + ++ +
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 254 PNARRIKKKKSKPPEKK 270
++I++++ K E++
Sbjct: 679 EQEKKIREQEEKIREQE 695
Score = 43.5 bits (101), Expect = 4e-04
Identities = 37/157 (23%), Positives = 70/157 (44%), Gaps = 4/157 (2%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
+DK+ R E E+I+ +E E I + +E+ QE+E ++ + +E ++
Sbjct: 569 EDKMWRQE-EKIREQEEKVWRQEEKIREQ---EEKRQEQEEKMWKQEEKIREQEEKIQEQ 624
Query: 137 ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEY 196
E K E+++ M + E + EK E + Q + + Q EK+ E++
Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
Query: 197 NKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
+ E+ MQE E K+ E+E++ + K E
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 721
Score = 42.7 bits (99), Expect = 8e-04
Identities = 39/199 (19%), Positives = 90/199 (45%), Gaps = 7/199 (3%)
Query: 77 QDKIRRLELERIQAEESV---KTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
Q+++ R E E+I +E + K E E + +E++ +E E+ + +E ++
Sbjct: 475 QEEMWRQE-EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM 533
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
E K + +Q E R K E E+ EK+ E + + ++ Q EK+ E
Sbjct: 534 WRQEEK---IREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE 590
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCV 253
++ + + E+KM + E K+ E+E++ + + K E + + + +++
Sbjct: 591 EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650
Query: 254 PNARRIKKKKSKPPEKKSS 272
++ +++ K E++ +
Sbjct: 651 EQEEKMCEQEEKMQEQEET 669
Score = 40.0 bits (92), Expect = 0.005
Identities = 43/173 (24%), Positives = 78/173 (45%), Gaps = 14/173 (8%)
Query: 73 LKNLQDKIRRLELE-RIQAEE---------SVKTLSRETIEYKKVLDEQIQERENSKNEE 122
++ ++K+ R E + R Q E+ + RE E + +E+I+E+E E+
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ 638
Query: 123 SKHNQELTSQLLAAENK-CNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH 181
+ QE ++ E K C EK E M + E R EK++ + E+ +Q
Sbjct: 639 EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQ--EKKIREQEEKIREQEE 696
Query: 182 -VQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
+Q Q EK+ E++ + E+KM+ E K+ E+E ++ + K E
Sbjct: 697 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 39.7 bits (91), Expect = 0.006
Identities = 36/160 (22%), Positives = 76/160 (47%), Gaps = 11/160 (6%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVL--DEQIQERENSKNEESKHNQELTSQLL 134
Q+KI E + Q ++ + + + +KV +E+I+E+E + E+ + + ++
Sbjct: 556 QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR 615
Query: 135 AAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH-VQSQLEKLDLLE 193
E K E+++ I+ E E T E+++ + E+ +Q +Q Q E + E
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQE-EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
++ + EKK++E E K+ E+E+ + + K E
Sbjct: 675 EKIRE-------QEKKIREQEEKIREQEEMMQEQEEKMWE 707
Score = 39.3 bits (90), Expect = 0.008
Identities = 39/186 (20%), Positives = 80/186 (43%), Gaps = 21/186 (11%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNE--------ESK 124
++ ++KIR E + + EE + + E K+ E++ +E +E E
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 125 HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEK-----QVSLERERQHDQ 179
H QE ++ E K E+++ I+ E + EK ++ E E+ H+Q
Sbjct: 499 HEQE--EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556
Query: 180 THV------QSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAE 233
+ Q Q +K+ E++ + E+K++E E K E+E++ + + K E
Sbjct: 557 EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE 616
Query: 234 LQTGLE 239
+ ++
Sbjct: 617 QEEKIQ 622
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 59.3 bits (142), Expect = 8e-09
Identities = 98/425 (23%), Positives = 179/425 (42%), Gaps = 49/425 (11%)
Query: 41 SDKPFLNSDL-----RRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELE----RIQAE 91
S K L S L + S + T E + + A + +Q ++R L+LE R QAE
Sbjct: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 92 E----SVKTLSRETIEYKKVLDEQI--------QERENSKNEESKHNQELTSQLLAAENK 139
+ + + L++ E K L++Q Q RE + E S H QEL L + E +
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 140 CNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE---QEY 196
LE +L+ + EME ++ + E Q ++++ E++ LLE Q
Sbjct: 884 KMELEMRLKEQQT-----EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ 938
Query: 197 NKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL-ETNRLIFEDKATPCVPN 255
+L E+ Q+++ + +E++ +Q + E Q L E R +D A +
Sbjct: 939 KELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEES 998
Query: 256 ARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQ-----LV 310
+ ++ K + + ++ AQ + + + T + + ++ L
Sbjct: 999 SSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLT 1058
Query: 311 LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDE 370
L LM++ + L L + S R + L + G +ELS ++ L+ E
Sbjct: 1059 LSLMEKEQRLLV---------LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
Query: 371 FGQMSFDH-QQLAKLIQESPTVELKDKLECELEALVGRMEAKANQI-TKVRKYQAQLEKQ 428
+ D Q A+L++E +E E +L A + EAKA Q+ ++R ++QLE
Sbjct: 1110 VKEKEADFLAQEAQLLEE---LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
Query: 429 KLEKQ 433
E+Q
Sbjct: 1167 AAEQQ 1171
Score = 54.3 bits (129), Expect = 3e-07
Identities = 81/434 (18%), Positives = 186/434 (42%), Gaps = 52/434 (11%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
++L + R + E + +E ++ L + K+L+E +++ + S E + ELT+Q
Sbjct: 1647 EHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR---ELTTQR 1703
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
+ + + + R ++H ++ EK+V ++E H+ ++ QLE+ L+
Sbjct: 1704 QLMQERAEEGKGPSKAQRGSLEHMKLILRDK-EKEVECQQEHIHELQELKDQLEQ--QLQ 1760
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCV 253
+ K+ L ++ QE+ + ++ R++ + K LQ+ L+
Sbjct: 1761 GLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD-------------- 1806
Query: 254 PNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHL 313
A+R ++ + E Q + G V K+ + A+ Q + L
Sbjct: 1807 -EAQRALAQRDQELE--------ALQQEQQQAQGQEERVKEKADALQGAL---EQAHMTL 1854
Query: 314 MKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQ 373
++H + D + L ++++ G + + L + E + L LQ + +
Sbjct: 1855 KERHGE--LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE 1912
Query: 374 MSFDHQQLAKLIQES---PTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKL 430
+ +H+ + +Q+S LK++ + ELEAL ++ +Q + + +A+ ++ L
Sbjct: 1913 QAQEHEVETRALQDSWLQAQAVLKER-DQELEALRAESQSSRHQ-EEAARARAEALQEAL 1970
Query: 431 EKQKKELKATKKTLDEERN-SSSRSGITGTTNK------------KDFMKLRPGEKRRKN 477
K L+ ++ L E+ S S T T ++ ++++ GE + ++
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
Query: 478 LQLLKDMQSIQNSL 491
L+ +D+Q +Q +L
Sbjct: 2031 LRYQEDVQQLQQAL 2044
Score = 50.1 bits (118), Expect = 5e-06
Identities = 94/474 (19%), Positives = 182/474 (38%), Gaps = 111/474 (23%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
ES + + +LQ ++RR EL+R++A+ E +Q + + +
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGE---------------RELLQAAKENLTAQ 1356
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMIK------HAEMERTSVLEKQVSL----- 171
+H Q + A + +LE+ L R+ +K +E ER L++Q L
Sbjct: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQG 1416
Query: 172 ---------------ERERQHDQTHVQSQ-LEK--------LDLLEQEYNKLTTMQALAE 207
ERE + + Q Q LEK L+LL + K L +
Sbjct: 1417 KALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQ 1476
Query: 208 KKMQELEA----------KLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNAR 257
+++QELE + E EQ+ + + EL+ ET R + E + +
Sbjct: 1477 EQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQ 1536
Query: 258 RIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQH 317
I+ ++ + + K +V L L L + H
Sbjct: 1537 MIESQRGQVQDLKKQ------------------------------LVTLECLALELEENH 1566
Query: 318 SKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFD 377
K C ++I + ++ ++++++T + + EE S+ LQ + +
Sbjct: 1567 HKMECQQKLIKELEGQRE-------TQRVALTHLTLD--LEERSQELQAQSSQIHDLESH 1617
Query: 378 HQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKEL 437
LA+ +QE E+K + E ++E L R + Q + R + L+K++++ + +
Sbjct: 1618 STVLARELQERDQ-EVKSQRE-QIEEL-QRQKEHLTQDLERRDQELMLQKERIQVLEDQR 1674
Query: 438 KATKKTLDEERNS---SSRSGITGTTNKKDFMKLR------PGEKRRKNLQLLK 482
K L+E+ S R T ++ M+ R P + +R +L+ +K
Sbjct: 1675 TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK 1728
Score = 46.2 bits (108), Expect = 7e-05
Identities = 81/432 (18%), Positives = 172/432 (39%), Gaps = 44/432 (10%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
+ LQ+ + LE ++ ++ + TL RE +E + E +++ + ++ ++L
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITL-REALESSHLEGELLRQEQTEVTAALARAEQSIAEL 580
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
++EN L + + +K + + L+K V L ++ + QS +++ E
Sbjct: 581 SSSEN--TLKTEVADLRAAAVKLSALNEALALDK-VGLNQQLLQLEEENQSVCSRMEAAE 637
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCV 253
Q N L A AEK+ + L K E + ++ + AELQ L R I E+K
Sbjct: 638 QARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADL---RDIQEEK----- 689
Query: 254 PNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHL 313
I+KK S+ ++ + A H + VL
Sbjct: 690 ---EEIQKKLSESRHQQEA--------------------ATTQLEQLHQEAKRQEEVLAR 726
Query: 314 MKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQ---TLQDE 370
Q +AL ++ + L R +++L + + L E Q ++
Sbjct: 727 AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT 786
Query: 371 FGQMSFDHQQL--AKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQ 428
GQ+ Q + AK + + LK +L+ E +A A Q+ + + +Q
Sbjct: 787 KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
Query: 429 KLEKQKKELKATKKTLDEERN---SSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQ 485
+ +KE+ ++ ++ER+ + +K +++R E++ + ++ ++ +
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE-MEAIQAQR 905
Query: 486 SIQNSLQSSSLC 497
+ + S+LC
Sbjct: 906 EEERTQAESALC 917
Score = 45.8 bits (107), Expect = 9e-05
Identities = 84/445 (18%), Positives = 194/445 (43%), Gaps = 45/445 (10%)
Query: 76 LQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLA 135
L+D++++LE ER+ E+ K+ ++ L Q+ + + K++ L S+L+
Sbjct: 1262 LRDQVQKLE-ERLTDTEAEKSQVHTELQ---DLQRQLSQNQEEKSKWEGKQNSLESELME 1317
Query: 136 AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHV---QSQLEKLDLL 192
L+ +L A+ ER + + +L + +H Q V ++Q +L
Sbjct: 1318 LHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGIL 1377
Query: 193 EQEYNKLTTMQALAEKKMQELE-----AKLHEEEQERKRMQAKAAELQTGLETNRLIFED 247
E++ L T ++ + K +E+E A+ +E+ E K Q KA + L T L +
Sbjct: 1378 EED---LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAERE 1434
Query: 248 KATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANV 307
+ + +I++ + + +K++ R D+ + +V+ ++
Sbjct: 1435 EEVETLRG--QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 308 QLV-------LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEEL 360
+ L + ++ + L DR L Q+ K + + S G ++L
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE----SQRGQVQDL 1548
Query: 361 SEVLQTLQDEFGQMSFDHQQL---AKLI------QESPTVELKDKLECELEALVGRMEAK 411
+ L TL+ ++ +H ++ KLI +E+ V L L +LE ++A+
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVAL-THLTLDLEERSQELQAQ 1607
Query: 412 ANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPG 471
++QI + + L ++ L+++ +E+K+ ++ ++E + + +T ++D +
Sbjct: 1608 SSQIHDLESHSTVLARE-LQERDQEVKSQREQIEELQR--QKEHLTQDLERRDQELM--- 1661
Query: 472 EKRRKNLQLLKDMQSIQNSLQSSSL 496
+++ +Q+L+D ++ Q + L
Sbjct: 1662 -LQKERIQVLEDQRTRQTKILEEDL 1685
Score = 42.0 bits (97), Expect = 0.001
Identities = 80/405 (19%), Positives = 169/405 (41%), Gaps = 57/405 (14%)
Query: 127 QELTSQLLAAENKCNLLEKQLEY-------MRNMIKHAEMERTSVLEKQV-------SLE 172
Q+L QL + NLL++Q + +R ++ ER ++ + V SL
Sbjct: 403 QDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLS 462
Query: 173 RERQHDQTHVQSQLEKLDLLEQEYNKLTTMQA-------LAEKKMQELEAKLHEEEQERK 225
+ER+ Q + ++L++LEQE +L + A+ + +E + +LH +ER+
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE 522
Query: 226 RMQ-------AKAAE-------LQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKS 271
R+Q AK +E L+ LE++ L E + + + E S
Sbjct: 523 RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582
Query: 272 SRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAV----VANVQLVLHLMKQHSKALCNDRVI 327
S N + + D+ A K ++ + A+ V Q +L L +++
Sbjct: 583 SENTLKTE------VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAA 636
Query: 328 NSIPLAKQVSSRGGKSKKLSVTPPSSN--GINEELSEVLQTLQDEFGQMSFDHQQLAKLI 385
A QV + ++ ++ +++ ++ E LQ + + + +++ K +
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 386 QESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLD 445
ES ++ +LE L EAK + R Q EK+ L ++K L+ + ++
Sbjct: 697 SESR--HQQEAATTQLEQL--HQEAKRQEEVLARAVQ---EKEALVREKAALEVRLQAVE 749
Query: 446 EERNSSSRSGITGTTNKKDFMKLRPGEKRRKN--LQLLKDMQSIQ 488
+R + + G ++ K+ ++ E +++N +++ K +Q
Sbjct: 750 RDRQDLAEQ-LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/182 (22%), Positives = 79/182 (43%), Gaps = 7/182 (3%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E + + + L+ L LE +A++ + + + + Q +E + E
Sbjct: 749 ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQT-- 180
EL ++ AE + + +QL K A ++ + EK+V+ RE+ +
Sbjct: 809 RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW 868
Query: 181 HVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLET 240
H Q + L+ LE+E M+ K Q+ E + + ++E +R QA++A Q LET
Sbjct: 869 HQQELAKALESLERE-----KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923
Query: 241 NR 242
+
Sbjct: 924 EK 925
Score = 40.4 bits (93), Expect = 0.004
Identities = 47/194 (24%), Positives = 87/194 (44%), Gaps = 27/194 (13%)
Query: 77 QDKIRRLELERIQAEESVK-TLSRETIEYK----KVLDEQIQERENSKNEESK------H 125
Q+ +++L+ Q +E ++ RE + K +V + IQE++N E + H
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
Query: 126 NQELTSQLLAAENKCNLLEKQLEYMRNMIKH-AEMERTSVLEKQV----SLERERQHDQT 180
QL A+ + +LE + RN ++ +TS +E+Q SLE Q +
Sbjct: 2094 QSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELE 2153
Query: 181 HVQSQLEKLDLLEQEYNKLTTMQAL-------AEKKMQE----LEAKLHEEEQERKRMQA 229
+Q+ L + + E E+ + AL + +QE L+A + E + E++R+Q
Sbjct: 2154 RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQD 2213
Query: 230 KAAELQTGLETNRL 243
+ + LE RL
Sbjct: 2214 ELELTRRALEKERL 2227
Score = 37.4 bits (85), Expect = 0.032
Identities = 39/166 (23%), Positives = 72/166 (43%), Gaps = 10/166 (6%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYK---KVLDEQIQERENSKNEESKHNQEL 129
L+ LQ +R+ E I+ E + L+ + K L E + S E Q L
Sbjct: 2152 LERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL 2211
Query: 130 TSQLLAAENKCNLLEKQLEYMRNMIKHAEM----ERTSVLEKQVSLERERQHDQTHVQSQ 185
+L E LEK+ + AE+ E+ L + +E E D QS
Sbjct: 2212 QDEL---ELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSW 2268
Query: 186 LEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKA 231
++L+ L+Q +L ++ ++ +L + L + E+ER++++ +A
Sbjct: 2269 RQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314
Score = 37.0 bits (84), Expect = 0.042
Identities = 47/221 (21%), Positives = 98/221 (44%), Gaps = 39/221 (17%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTL------------SRETIEYKKVLDE 110
E+ + L L+ K + +E +R Q ++ K L + +E ++ L +
Sbjct: 1518 ETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK 1577
Query: 111 QIQERENSKNEESKHN----QELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLE 166
+++ + ++ H +E + +L A ++ + LE + ++ + E S E
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 167 KQVSLERERQH--------DQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLH 218
+ L+R+++H DQ + Q E++ +LE + + T + E+ +++++ L
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQ-ELMLQKERIQVLEDQRTRQT---KILEEDLEQIKLSLR 1693
Query: 219 EEEQE----RKRMQAKAAE------LQTG-LETNRLIFEDK 248
E +E R+ MQ +A E Q G LE +LI DK
Sbjct: 1694 ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDK 1734
Score = 36.2 bits (82), Expect = 0.071
Identities = 37/209 (17%), Positives = 86/209 (41%), Gaps = 21/209 (10%)
Query: 72 ALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQ---IQERENSKNEESKHNQE 128
AL ++ L+ E+ QA+ + + + + L++ ++ER + + +
Sbjct: 1811 ALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARR 1870
Query: 129 LTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHD---------- 178
L +L + LE+ L +R + E E+ + +Q E+ ++H+
Sbjct: 1871 LEEELAVEGRRVQALEEVLGDLR--AESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
Query: 179 ---QTHVQSQLEKLDLLEQEYNKLTTMQALAEKK---MQELEAKLHEEEQERKRMQAKAA 232
Q ++ + ++L+ L E + A + +QE K H Q +++ + A
Sbjct: 1929 LQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQA 1988
Query: 233 ELQTGLETNRLIFEDKATPCVPNARRIKK 261
EL LE + + C ++R++++
Sbjct: 1989 ELSRSLEASTATLQASLDACQAHSRQLEE 2017
Score = 35.4 bits (80), Expect = 0.12
Identities = 24/112 (21%), Positives = 49/112 (43%)
Query: 128 ELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLE 187
+L L + ++L Q++ + + E E++ V + L+R+ +Q
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306
Query: 188 KLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLE 239
K + LE E +L A + +++ E + E + ER+ +QA L +E
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358
Score = 34.7 bits (78), Expect = 0.21
Identities = 45/194 (23%), Positives = 79/194 (40%), Gaps = 33/194 (17%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEES--------- 123
+K L++ + LE + E +LSR E K L + I++ EE
Sbjct: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGH 365
Query: 124 KHNQELTSQLLA------AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQH 177
+++ EL S + + A+ L+ L R ++ + E L++ QH
Sbjct: 366 ENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ--QH 423
Query: 178 DQTH-----VQSQLEKLDL-----------LEQEYNKLTTMQALAEKKMQELEAKLHEEE 221
DQ ++ +L+KL L+ E + L+ + L +K +EL +L E
Sbjct: 424 DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
Query: 222 QERKRMQAKAAELQ 235
QE R++ ELQ
Sbjct: 484 QEAWRLRRVNVELQ 497
Score = 30.8 bits (68), Expect = 3.0
Identities = 21/111 (18%), Positives = 46/111 (41%), Gaps = 14/111 (12%)
Query: 79 KIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAEN 138
K + LE E + + + L + K L +++ E + K N++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED---------- 301
Query: 139 KCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKL 189
EK ++ +R ++ E T ++E + SL R Q ++ +Q ++ +
Sbjct: 302 ----YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDI 348
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 58.9 bits (141), Expect = 1e-08
Identities = 94/468 (20%), Positives = 192/468 (41%), Gaps = 76/468 (16%)
Query: 71 SALKNLQDKIRRLELER-IQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQEL 129
++L+ ++ K+ + E + ++ E+++ L I+ K++ E +Q + NE++K
Sbjct: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL--EVLQAK---CNEQTKVIDNF 716
Query: 130 TSQLLAAENKC-----------------NLLEKQLEYMRNMIKHAEMERTSVLEKQVSLE 172
TSQL A E K L +QLE IKH E+E+ + K S+
Sbjct: 717 TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
Query: 173 RERQ-------------HDQTHVQSQLEK-LDLLEQEYNKLTTMQALAEKKMQELEAKLH 218
RE Q + + V+ LEK L +L++++ + + ++ MQE KLH
Sbjct: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 836
Query: 219 EEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGA 278
++E++ + + +L+ L F +K + IK K+ + G
Sbjct: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDE---REEQLIKAKEKLENDIAEIMKMSGD 893
Query: 279 QPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSS 338
+ D + + +L L L K + A + I + + + S
Sbjct: 894 NSSQLTKMNDELRLKERDVE---------ELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
Query: 339 RGGKSK----------KLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQES 388
+ K KLS + + E+ + + H+++ + +Q++
Sbjct: 945 QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1004
Query: 389 PTVELKDKLEC---ELEALVGRMEAKANQITKVRKYQ-AQLEKQKLEKQKKELKATKKTL 444
++ +DKL+ E L+ +E Q K + Q A+ Q +E+ KE T +L
Sbjct: 1005 -LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1063
Query: 445 DEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLL---KDMQSIQN 489
++ + ++++ N+ D +K E KN++ L K++ +++N
Sbjct: 1064 EDTKQTNAK-----LQNELDTLK----ENNLKNVEELNKSKELLTVEN 1102
Score = 57.0 bits (136), Expect = 4e-08
Identities = 107/474 (22%), Positives = 194/474 (40%), Gaps = 91/474 (19%)
Query: 81 RRLELERIQAEESVKTLSRETIEYK-KVLDEQIQERENSKNEESKHNQELTSQLLAAENK 139
R L+L +Q S + +ET+E + ++L E+ E + QE ++L E +
Sbjct: 782 RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ 841
Query: 140 CNLLEKQLEYMRNMIKHAEM---ERTSVLEKQVSLERERQHDQTHVQ-------SQLEKL 189
N+L LE +R + E E+ E+ + + + ++D + SQL K+
Sbjct: 842 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 901
Query: 190 D----LLEQEYNKLTT------------------MQALAEKKMQELEAKLHEEEQERKRM 227
+ L E++ +L M AE+ QE AK HEEE +K +
Sbjct: 902 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA-AKKHEEE--KKEL 958
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKK-------------SSRN 274
+ K ++L+ +ET+ C R ++ S+ K +
Sbjct: 959 ERKLSDLEKKMETSH-------NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1011
Query: 275 YFGAQPHYRLCLGDMPFVAGKSTSPSHAVVAN--VQLVLHLMKQHSKALC--------ND 324
GA+ L ++ + ++ A A +Q++ + K+ ++ L N
Sbjct: 1012 LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1071
Query: 325 RVINSIPLAKQVSSRG----GKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQ 380
++ N + K+ + + KSK+L N EE + ++TL+ Q S QQ
Sbjct: 1072 KLQNELDTLKENNLKNVEELNKSKELLTV---ENQKMEEFRKEIETLKQAAAQKS---QQ 1125
Query: 381 LAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKAT 440
L+ L +E+ V+L ++L GR + K+ + ++ L Q LE +K+E K
Sbjct: 1126 LSALQEEN--VKLAEEL--------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1175
Query: 441 KKTLDEERNSSSRS-GITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQS 493
K DEE+ S +S IT + +L EK R + +L+ + SL S
Sbjct: 1176 KDA-DEEKASLQKSISITSALLTEKDAEL---EKLRNEVTVLRGENASAKSLHS 1225
Score = 36.6 bits (83), Expect = 0.055
Identities = 100/509 (19%), Positives = 217/509 (42%), Gaps = 104/509 (20%)
Query: 47 NSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKK 106
++ L+RSPS +L+ S + ++ S + + + R + S T +E ++ K+
Sbjct: 304 SASLKRSPSASSLSSMSSVASSVSS--RPSRTGLLTETSSRYARKISGTTALQEALKEKQ 361
Query: 107 VLDEQI-QERENSKNEESK---HNQELTSQLLAAENKCNL----LEKQLEYMRNMIKHAE 158
EQ+ ER+ + E +K H E+ +L A + + LE +++ +R M++ A+
Sbjct: 362 QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421
Query: 159 MERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKK---MQELE- 214
E+ +E L+ LE+E K+ +Q E++ +LE
Sbjct: 422 REK------------------------VELLNQLEEEKRKVEDLQFRVEEESITKGDLEV 457
Query: 215 ------AKLHEEEQERKRMQAKAAELQTGLETNRLIFE-DKATPCVPNARRIKKK----- 262
+++ E E++ + AEL+ LE+N+ + D + + +++K
Sbjct: 458 ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 517
Query: 263 KSKPPEKKSSRNYFGAQPH-YRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKAL 321
E S + +FGA+ ++ + + K + + ++ + ++ H K++S +
Sbjct: 518 TDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLE---HANKENSDVI 574
Query: 322 CNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQ-- 379
+ L ++S ++L V+ S G+ E +E + L+ + +M D+Q
Sbjct: 575 ----ALWKSKLETAIASHQQAMEELKVS--FSKGLGTETAEFAE-LKTQIEKMRLDYQHE 627
Query: 380 ------------------------QLAKLIQE---------SPTVELKDKLECELEALVG 406
+L K+I+E S + +D+ E+E +
Sbjct: 628 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 687
Query: 407 RMEAKANQITKVRKYQAQLEKQK--LEKQKKELKATKK---TLDEERNSSSRSGITGTTN 461
+++ ++ ++ QA+ +Q ++ +LKAT++ LD R +SS +
Sbjct: 688 KLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG---KSEM 744
Query: 462 KKDFMKLRPGEKRRKNLQLLKDMQSIQNS 490
KK +L EK+ K+L++ K+ +S + S
Sbjct: 745 KKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 58.9 bits (141), Expect = 1e-08
Identities = 94/468 (20%), Positives = 192/468 (41%), Gaps = 76/468 (16%)
Query: 71 SALKNLQDKIRRLELER-IQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQEL 129
++L+ ++ K+ + E + ++ E+++ L I+ K++ E +Q + NE++K
Sbjct: 697 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL--EVLQAK---CNEQTKVIDNF 751
Query: 130 TSQLLAAENKC-----------------NLLEKQLEYMRNMIKHAEMERTSVLEKQVSLE 172
TSQL A E K L +QLE IKH E+E+ + K S+
Sbjct: 752 TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 811
Query: 173 RERQ-------------HDQTHVQSQLEK-LDLLEQEYNKLTTMQALAEKKMQELEAKLH 218
RE Q + + V+ LEK L +L++++ + + ++ MQE KLH
Sbjct: 812 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 871
Query: 219 EEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGA 278
++E++ + + +L+ L F +K + IK K+ + G
Sbjct: 872 QKEEQFNMLSSDLEKLRENLADMEAKFREKDE---REEQLIKAKEKLENDIAEIMKMSGD 928
Query: 279 QPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSS 338
+ D + + +L L L K + A + I + + + S
Sbjct: 929 NSSQLTKMNDELRLKERDVE---------ELQLKLTKANENASFLQKSIEDMTVKAEQSQ 979
Query: 339 RGGKSK----------KLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQES 388
+ K KLS + + E+ + + H+++ + +Q++
Sbjct: 980 QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1039
Query: 389 PTVELKDKLEC---ELEALVGRMEAKANQITKVRKYQ-AQLEKQKLEKQKKELKATKKTL 444
++ +DKL+ E L+ +E Q K + Q A+ Q +E+ KE T +L
Sbjct: 1040 -LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1098
Query: 445 DEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLL---KDMQSIQN 489
++ + ++++ N+ D +K E KN++ L K++ +++N
Sbjct: 1099 EDTKQTNAK-----LQNELDTLK----ENNLKNVEELNKSKELLTVEN 1137
Score = 57.0 bits (136), Expect = 4e-08
Identities = 107/474 (22%), Positives = 194/474 (40%), Gaps = 91/474 (19%)
Query: 81 RRLELERIQAEESVKTLSRETIEYK-KVLDEQIQERENSKNEESKHNQELTSQLLAAENK 139
R L+L +Q S + +ET+E + ++L E+ E + QE ++L E +
Sbjct: 817 RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ 876
Query: 140 CNLLEKQLEYMRNMIKHAEM---ERTSVLEKQVSLERERQHDQTHVQ-------SQLEKL 189
N+L LE +R + E E+ E+ + + + ++D + SQL K+
Sbjct: 877 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 936
Query: 190 D----LLEQEYNKLTT------------------MQALAEKKMQELEAKLHEEEQERKRM 227
+ L E++ +L M AE+ QE AK HEEE +K +
Sbjct: 937 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA-AKKHEEE--KKEL 993
Query: 228 QAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKK-------------SSRN 274
+ K ++L+ +ET+ C R ++ S+ K +
Sbjct: 994 ERKLSDLEKKMETSH-------NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1046
Query: 275 YFGAQPHYRLCLGDMPFVAGKSTSPSHAVVAN--VQLVLHLMKQHSKALC--------ND 324
GA+ L ++ + ++ A A +Q++ + K+ ++ L N
Sbjct: 1047 LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1106
Query: 325 RVINSIPLAKQVSSRG----GKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQ 380
++ N + K+ + + KSK+L N EE + ++TL+ Q S QQ
Sbjct: 1107 KLQNELDTLKENNLKNVEELNKSKELLTV---ENQKMEEFRKEIETLKQAAAQKS---QQ 1160
Query: 381 LAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKAT 440
L+ L +E+ V+L ++L GR + K+ + ++ L Q LE +K+E K
Sbjct: 1161 LSALQEEN--VKLAEEL--------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1210
Query: 441 KKTLDEERNSSSRS-GITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQS 493
K DEE+ S +S IT + +L EK R + +L+ + SL S
Sbjct: 1211 KDA-DEEKASLQKSISITSALLTEKDAEL---EKLRNEVTVLRGENASAKSLHS 1260
Score = 32.3 bits (72), Expect = 1.0
Identities = 50/215 (23%), Positives = 95/215 (44%), Gaps = 44/215 (20%)
Query: 47 NSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKK 106
++ L+RSPS +L+ S + ++ S + + + R + S T +E ++ K+
Sbjct: 304 SASLKRSPSASSLSSMSSVASSVSS--RPSRTGLLTETSSRYARKISGTTALQEALKEKQ 361
Query: 107 VLDEQI-QERENSKNEESK---HNQELTSQLLAAENKCNL----LEKQLEYMRNMIKHAE 158
EQ+ ER+ + E +K H E+ +L A + + LE +++ +R M++ A+
Sbjct: 362 QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421
Query: 159 MERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKK--------- 209
E+ +E L+ LE+E K+ +Q E++
Sbjct: 422 REK------------------------VELLNQLEEEKRKVEDLQFRVEEESITKGDLET 457
Query: 210 MQELE-AKLHEEEQERKRMQAKAAELQTGLETNRL 243
+LE A++ E EQ + KA +LQ LE R+
Sbjct: 458 QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRV 492
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 58.9 bits (141), Expect = 1e-08
Identities = 88/455 (19%), Positives = 196/455 (43%), Gaps = 54/455 (11%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
+S+++ + LK Q ++++L+ + I+ +E + L R + V E
Sbjct: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFV------------QTE 2051
Query: 123 SKHNQELTSQLLA-AENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH 181
S+ + E+T + LA A + +L + ++ + E VL + L++E Q ++
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 182 VQSQLEKLDL-LEQEYNKLTTMQALAEKKMQE-----------LEAKLHEEEQERKRMQA 229
V+SQ+++ D LE+ + +K MQE LE + E + +
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
Query: 230 KAAELQTGLETN--RLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLG 287
+ +LQ L++ +L K+ + + R ++K E+K S + RL
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2231
Query: 288 DMPFVAGKSTSPSHAVVANVQLVLHLMK-QHSKALCNDRVINSIPLAKQVSSRGGKSKKL 346
+ + + S + +L +++ + +H K + + + L ++V
Sbjct: 2232 NCSVLKDQLRQMS---IHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT------- 2281
Query: 347 SVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVG 406
+ E E+L L++ +LAKL ES LKD+L +L
Sbjct: 2282 ---------LQGENKELLSQLEETRHLYHSSQNELAKL--ESELKSLKDQLTDLSNSLEK 2330
Query: 407 RMEAKANQITKVRKYQAQLEKQKL--EKQKKELKATKK---TLDEERNSSSRSGITGTTN 461
E K N +R+ +A ++ K E+ + +L+A+++ L EE N + I+ +
Sbjct: 2331 CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSG 2390
Query: 462 KKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSL 496
K++ +++ E R+++ + +K+++++ + + ++
Sbjct: 2391 KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425
Score = 50.4 bits (119), Expect = 4e-06
Identities = 85/423 (20%), Positives = 175/423 (41%), Gaps = 53/423 (12%)
Query: 58 TLAYPESNSRAIFSALKNLQDKIRRLELE-RIQAEESVKTLSRETIEYK-----KVLDEQ 111
TL S ++A +A + +++K R E + R+ +E ++ +++ +E + +VL +
Sbjct: 201 TLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK 260
Query: 112 IQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM-------RNMIKHAEMERTSV 164
++E E S ++ L +L AAE + +L +QL+ M RN ++ E +
Sbjct: 261 LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKIL 320
Query: 165 LEKQVSLERER-------QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKL 217
LEK ER Q + H+ Q E+ + E + AL +K E+E K
Sbjct: 321 LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE--SRYSALEQKHKAEMEEKT 378
Query: 218 HEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYF- 276
+K Q + + N + +DK V +A+ I++ + + +K + F
Sbjct: 379 SHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL 438
Query: 277 ---GAQPHYRLCLGDMPFVAGKST-SPSHAVVANVQ------------LVLHLMKQHSKA 320
Q H P V + T + + +A++Q L+L ++
Sbjct: 439 NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELK 498
Query: 321 LCNDRVINSIPLAKQVSSRGGKSKKLS------VTPPSSNGINEELSEVLQTLQDEFGQM 374
N+++ + I L + + G +++S + S+ E +VL+
Sbjct: 499 AENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLE------NTF 552
Query: 375 SFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQK 434
S H++L+ L+ E E ++++ L G+ +A+ +K Q+E + + K
Sbjct: 553 SQKHKELSVLLLEMK--EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK 610
Query: 435 KEL 437
++
Sbjct: 611 MKV 613
Score = 47.0 bits (110), Expect = 4e-05
Identities = 86/425 (20%), Positives = 172/425 (40%), Gaps = 44/425 (10%)
Query: 66 SRAIFSALKNLQDKIRRL--ELERIQAEESVKTLSRETIEYKKVL-----DEQIQERENS 118
++++ L + I RL L ++++ S + ++T+ + L D+ I E + S
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558
Query: 119 KNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQ-- 176
E + S LA E EK ++ + ++ E T EK L++E +
Sbjct: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1618
Query: 177 --------HDQTHVQSQLEKLDLLEQE-YNKLTTMQAL---AEKKMQELEAKLHEEEQER 224
++ +Q +E + +QE Y KL + +A EK++QE E ++ EE +E+
Sbjct: 1619 LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM-EEMKEK 1677
Query: 225 KRMQAKAAE---LQTGLETNRLIFE-----DKATPCVPNARRIKKKKSKPPEKKSSRNYF 276
R AK+ + L+ E +RL E D A C+ K ++ Y
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLS-SNASMKEELERVKMEYE 1736
Query: 277 GAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHL---MKQHSKALCNDRVINSIP-- 331
++ + + ++ + H + NV +L K ++ + SIP
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 332 LAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLI-----Q 386
+Q S S + PS+ N +S+ + DE QL + I +
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS-HDEINNYLQQIDQLKERIAGLEEE 1855
Query: 387 ESPTVELKDKLECELEALVGRMEAKANQITKVRK--YQAQLEKQKLEKQKKELKATKKTL 444
+ E LE E L+ ++ K ++ +++ + L Q+++++ + K+T
Sbjct: 1856 KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915
Query: 445 DEERN 449
+EE++
Sbjct: 1916 EEEKD 1920
Score = 44.3 bits (103), Expect = 3e-04
Identities = 37/177 (20%), Positives = 92/177 (51%), Gaps = 12/177 (6%)
Query: 67 RAIFSALKNLQDKIRRLELERIQAEESV-KTLSRETIEYKKVLDEQIQERENSKNEESKH 125
R + S + +L + +L+ E IQ E + + ++ + + K++L+ Q+Q+ + +N+ +K
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572
Query: 126 NQELTSQLLAAEN---KCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHV 182
++L A E+ N L+++ + + I+ ++ + + + +L+ E H
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 183 QSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLE 239
Q L + E+E ++L+ + + ++K++ ELE +L ++E + K E++ L+
Sbjct: 2633 Q-----LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAK---KVGEIEDKLK 2681
Score = 40.8 bits (94), Expect = 0.003
Identities = 38/148 (25%), Positives = 75/148 (50%), Gaps = 22/148 (14%)
Query: 74 KNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQ-----IQERENSKNEESKHNQE 128
K + + R+L+ I +E ++ +SR E + DE + E E + EE K N+E
Sbjct: 986 KENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKE 1045
Query: 129 LTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSV---LEKQVSLERE-----RQHDQT 180
+ + + +KC +E Y++ I E+E + LE++++ E + +Q +QT
Sbjct: 1046 YSEKCVT--SKCQEIE---IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
Query: 181 HVQSQLEKLDLLEQEYNKLTTMQALAEK 208
+Q + ++DLL+ E ++ QA+ +K
Sbjct: 1101 -LQDKTNQIDLLQAE---ISENQAIIQK 1124
Score = 40.0 bits (92), Expect = 0.005
Identities = 65/376 (17%), Positives = 145/376 (38%), Gaps = 47/376 (12%)
Query: 110 EQIQERENSKNEESKHNQE-----------LTSQLLAAENKCNLLEKQLEYMRNMIKHAE 158
+Q++ER EE + N+E L SQ+ + + +L++++ M + + +
Sbjct: 1843 DQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQ 1902
Query: 159 MERTSVLEKQVSLERERQHDQTHVQSQLEKL------------------DLLEQEYNKL- 199
E + V + + + E E+ + + +QL +L +LLE E L
Sbjct: 1903 EELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLK 1962
Query: 200 TTMQALAEKKMQELEAKLHEEEQERKRMQAK--AAELQTGLETNRLIFEDKATPCVPNAR 257
+ L E+K Q ++ K E + RK K A+ + G +++ ++ +
Sbjct: 1963 KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022
Query: 258 RIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQH 317
+++K + EK S+ + + FV +S N+ + K+
Sbjct: 2023 QLQKDCIRYQEKISA---------LERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 318 SKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFD 377
L + +V+ ++ K + + ++ + + L+ Q
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 378 HQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKEL 437
H + K +QE ++K+ LE +G ++ N+ K + Q ++ L+ +L
Sbjct: 2134 HLKEKKNMQEKLDALRREKV--HLEETIGEIQVTLNKKDK----EVQQLQENLDSTVTQL 2187
Query: 438 KATKKTLDEERNSSSR 453
A K++ ++ R
Sbjct: 2188 AAFTKSMSSLQDDRDR 2203
Score = 39.3 bits (90), Expect = 0.008
Identities = 80/443 (18%), Positives = 178/443 (40%), Gaps = 46/443 (10%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENS----KNEESKHNQE 128
L+ ++ I L+ + QA+ S +E ++ +Q+QE+E + + S+ E
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212
Query: 129 LTSQLLAAENKCNLLEKQL----EYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS 184
+Q + E E Q+ + + ++ A++E T + +K L+R+ + + +
Sbjct: 213 QAAQQVVREKDARF-ETQVRLHEDELLQLVTQADVE-TEMQQKLRVLQRKLEEHEESLVG 270
Query: 185 QLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244
+ + +DLL+QE + +++Q++EA E R ++ + E + LE L
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEA---EHNTLRNTVETEREESKILLEKMELE 327
Query: 245 FEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVV 304
++ + ++++ E+ A+ R + A SH +
Sbjct: 328 VAERKL----SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
Query: 305 -----ANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEE 359
+Q +K + L D+ ++ A+ + + ++ S I++
Sbjct: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQ------KSKEISQF 437
Query: 360 LSEVLQTLQDEFGQMSFD--HQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITK 417
L+ + + Q SF + + + + E L+ ++ ELE E A ++
Sbjct: 438 LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRV-VELE-----NEKGALLLSS 491
Query: 418 VRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKK---------DFMKL 468
+ + + E +KL Q L+A +T + +R S S I NK+ D ++
Sbjct: 492 IELEELKAENEKLSSQITLLEAQNRTGEADREVSEIS-IVDIANKRSSSAEESGQDVLEN 550
Query: 469 RPGEKRRKNLQLLKDMQSIQNSL 491
+K ++ LL +M+ Q +
Sbjct: 551 TFSQKHKELSVLLLEMKEAQEEI 573
Score = 39.3 bits (90), Expect = 0.008
Identities = 81/415 (19%), Positives = 173/415 (41%), Gaps = 54/415 (13%)
Query: 76 LQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL-- 133
L+D++R++ + + + ++ L + ++ ++Q ++ + N+EL SQL
Sbjct: 2236 LKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295
Query: 134 -----LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLE---RERQHD------- 178
+++N+ LE +L+ +++ + E++ +LE R+++ D
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 179 ----QTHVQSQLEKLDLLEQEYN----KLTTMQALAEKKMQ----ELEAKLHEEEQERKR 226
+T +Q+ E L +E N K+ ++ + E+ +Q EL + +E +E +
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
Query: 227 MQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSS--RNYFGAQPHYRL 284
+ ++ E LE DK + + IKK+ + + S ++ Q
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Query: 285 CLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSK 344
+GD + + S ++ QL+ +++K R + S + ++
Sbjct: 2476 IVGDYQQLEERHLS---IILEKDQLIQEAAAENNKLKEEIRGLRS-----HMDDLNSENA 2527
Query: 345 KLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELK-DKLECELEA 403
KL E+L++V+ T++D S Q L +Q++ +E K KLE +L
Sbjct: 2528 KLDA---ELIQYREDLNQVI-TIKD-----SQQKQLLEVQLQQNKELENKYAKLEEKL-- 2576
Query: 404 LVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITG 458
+ +AN+ + Q EKQ L K+ + LK + L + + G G
Sbjct: 2577 ---KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Score = 38.1 bits (87), Expect = 0.019
Identities = 34/184 (18%), Positives = 81/184 (44%), Gaps = 18/184 (9%)
Query: 65 NSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESK 124
N+ + F+AL +D++ L +++ V L + + + L E ++R ++
Sbjct: 734 NNSSAFTALSEERDQL----LSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTA 789
Query: 125 HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS 184
H+ LT Q+ + + + ++E ++N + +++ + SL+ + Q+ ++ V
Sbjct: 790 HDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
Query: 185 QLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244
E++ + K++EL L ++E E +M E + +ET +
Sbjct: 850 GAERVRHISS--------------KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT 895
Query: 245 FEDK 248
E+K
Sbjct: 896 IEEK 899
Score = 37.4 bits (85), Expect = 0.032
Identities = 34/164 (20%), Positives = 79/164 (48%), Gaps = 13/164 (7%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNE----ESKHNQE 128
+++LQ +++ E E ++ E V+ +S + E + L ++ E E +K + E K + E
Sbjct: 833 IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK--ELEITKMDQLLLEKKRDVE 890
Query: 129 LTSQLLAAENKCNLLEKQLEYMRNMIKHAE------MERTSVLEKQVSLERERQHDQTHV 182
Q + +++ + E M++ E +E ++ E+ L R + + V
Sbjct: 891 TLQQTIEEKDQ-QVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQV 949
Query: 183 QSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKR 226
+ E L+Q Y++++ ++++++Q L +E ++RKR
Sbjct: 950 EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993
Score = 37.4 bits (85), Expect = 0.032
Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 117 NSKNEES-KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERER 175
NS E S H ++L QLL+ + + L QLE N ++ S + SL+ ER
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ-------SFSKAMASLQNER 2845
Query: 176 QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQ 235
H+ ++LEK E+ + + + ++Q L+ + + +R R+ + LQ
Sbjct: 2846 D----HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901
Query: 236 TG-LETNRLIFE 246
L+ N+ I E
Sbjct: 2902 QQYLQINQEITE 2913
Score = 35.0 bits (79), Expect = 0.16
Identities = 95/469 (20%), Positives = 188/469 (40%), Gaps = 72/469 (15%)
Query: 76 LQDKIRRLELERIQAEESV-------KTLSRETIEYKKVLDEQIQERENSKN-------E 121
L++KI LE E+ Q ++ + K + ++ E ++ L E+++++++ N E
Sbjct: 1162 LEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE 1221
Query: 122 ESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH 181
+SK N+ + QL + + + E + + + T LE+ + E+ H Q
Sbjct: 1222 QSKENENIGDQL--RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 182 VQSQL-EKLDLLEQEYNKLTTMQALAEKKMQ---------ELEAKLHEEEQERKRMQAKA 231
++S L ++ + L ++A+ K Q ELE K+ E + +
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
Query: 232 AELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCL----- 286
+LQ + L E T V + + +S + +SS+ H R
Sbjct: 1340 FQLQEQINKQGLEIESLKT--VSHEAEV-HAESLQQKLESSQLQIAGLEHLRELQPKLDE 1396
Query: 287 ---------GDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVS 337
D+ +++G+ S A + +Q + + KAL L Q
Sbjct: 1397 LQKLISKKEEDVSYLSGQ-LSEKEAALTKIQTEIIEQEDLIKAL-------HTQLEMQAK 1448
Query: 338 SRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKL 397
+ K+L V EL E+ Q +E G+ S QQ+ + +Q + + K+ L
Sbjct: 1449 EHDERIKQLQV----------ELCEMKQK-PEEIGEESRAKQQIQRKLQ-AALISRKEAL 1496
Query: 398 ECELEALVGRMEAKANQITKVRKYQAQLEKQ--KLEKQKKELKATKKTLDEERN----SS 451
+ E ++L + I ++ K A +E Q K+K + L EER+
Sbjct: 1497 K-ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 452 SRSGI--TGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQSSSLCW 498
RS + ++ + +KL +L+K+++S+++S + S W
Sbjct: 1556 DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1604
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 58.9 bits (141), Expect = 1e-08
Identities = 90/435 (20%), Positives = 172/435 (39%), Gaps = 59/435 (13%)
Query: 41 SDKPFLNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRE 100
++K N +K LA E+ + + + L + L+L+ +QAE + E
Sbjct: 849 TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ-VQAEADALADAEE 907
Query: 101 T----IEYKKVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYM------ 150
I+ K L+ +I+E +E + N ELT++ E++C+ L+K ++ +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 151 --------RNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTM 202
N +K+ E + E L +E++ Q Q L+ L + E + N LT
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027
Query: 203 QALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKK 262
+ E+++ +LE L +E++ ++ +L+ L+ ++T N ++ +
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLK-----LAQESTMDTENDKQQLNE 1082
Query: 263 KSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQHSKALC 322
K K E + S + GK A+ +Q + ++ + L
Sbjct: 1083 KLKKKEFEMSN------------------LQGK-IEDEQALAIQLQKKIKELQARIEELE 1123
Query: 323 NDRVINSIPLAKQVSSRGGKSKKL---SVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQ 379
+ AK R S++L S + G E+ + + EF +M D +
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 380 QLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKA 439
+ +Q T K + A +G QI +++ KQKLEK+K ELK
Sbjct: 1184 E--STLQHEATAAALRKKHADSVAELG------EQIDSLQRV-----KQKLEKEKSELKM 1230
Query: 440 TKKTLDEERNSSSRS 454
L + S++
Sbjct: 1231 EINDLASNMETVSKA 1245
Score = 51.6 bits (122), Expect = 2e-06
Identities = 101/494 (20%), Positives = 209/494 (42%), Gaps = 83/494 (16%)
Query: 55 SKPTLAYPESNSRAIFSALKNL--QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQI 112
+K TLA+ ++R L+ +++ + EL+R ++ + + T +Y+ ++
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT-KYETDAIQRT 1387
Query: 113 QERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHA--EMERTSV----LE 166
+E E +K + ++ Q+ + A +KC LEK + ++N ++ ++ER++ L+
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALD 1447
Query: 167 KQ------VSLERERQHDQTHVQ---SQLEKLDL----------LEQEYNKLTTMQALAE 207
K+ V E ++++++T + SQ E L E+ + L T++ +
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENK 1507
Query: 208 KKMQELE----------AKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNAR 257
QE+ +HE E+ +K++ + +ELQT LE E + +
Sbjct: 1508 NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQL 1567
Query: 258 RIKKKKSKPPEKKSSRNYFGAQ---PHYRLCLGDMPFVAGKSTSPSHAVVANVQL----- 309
+ + KS+ K + ++ Q H R+ + + S + A+ ++
Sbjct: 1568 ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN 1627
Query: 310 -----VLHLMKQHSKALCNDRVINSI------PLAKQVSSRGGKSKKLSVTPPSSNGINE 358
+ H +Q ++AL N R I L + + ++L++ +N +
Sbjct: 1628 EMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQA 1687
Query: 359 ELSEVLQTLQ-DEFG-----QMSFDHQQLAKLI--QESPTVELKDKLECELEALVGRM-- 408
E+ E+ +L+ E G Q D + +L+ Q + + K KLE ++ + G M
Sbjct: 1688 EVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED 1747
Query: 409 --------EAKANQ-ITKVRKYQAQLEKQK-----LEKQKKELKATKKTLDEERNSSSRS 454
E KA + IT +L+K++ LE+ KK ++ T K L + + +
Sbjct: 1748 IVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL 1807
Query: 455 GITGTTNKKDFMKL 468
+ G KK KL
Sbjct: 1808 ALKG--GKKQIQKL 1819
Score = 49.7 bits (117), Expect = 6e-06
Identities = 88/479 (18%), Positives = 193/479 (40%), Gaps = 74/479 (15%)
Query: 64 SNSRAIFSAL-KNLQDKIRRLELERIQAEESVKTLSR-------ETIEYKKVLDE----- 110
S ++A F + + L+D++ ++ + + + + LS E+ E+ + LDE
Sbjct: 1243 SKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMV 1302
Query: 111 ------------QIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAE 158
QI+E + EE+K L L +A + C+LL +Q E E
Sbjct: 1303 SQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE--------EE 1354
Query: 159 MERTSVLEKQVSLERER--QHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAK 216
E + L++ +S Q + +++ + LE+ KL AE+ ++ + +K
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 217 LHEEEQERKRMQAKAAELQTGLETNR--LIFEDKATPCVPNARRIKKKK----------S 264
E+ ++R+Q + +L +E + I DK K+K S
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 265 KPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAV------VANVQLVLHLMKQHS 318
+ + S F + Y L + + ++ + + +A +H +++
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK 1534
Query: 319 KALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDH 378
K L +++ L + +S + K+ N + E+ + +E Q+ +H
Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNH 1594
Query: 379 QQLAKLIQESPTVELKD-----KLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQ 433
++ + +Q + E++ +++ ++E + ME + N + QA + L
Sbjct: 1595 LRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR----QAAEALRNLRNT 1650
Query: 434 KKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQLLKDMQSIQNSLQ 492
+ LK T+ LD+ I G + K+ + + +RR NL + +++ ++ SL+
Sbjct: 1651 QGILKDTQLHLDD--------AIRGQDDLKEQLAM---VERRANL-MQAEVEELRASLE 1697
Score = 44.7 bits (104), Expect = 2e-04
Identities = 78/382 (20%), Positives = 156/382 (40%), Gaps = 59/382 (15%)
Query: 100 ETIEYKKVLDEQIQERENSKNEESK---HNQELTSQLLAAENKCNLLEKQLEYMRNMIKH 156
++ E +K + +E E +K E +K +EL +++ + N L+ Q++ + +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 157 AEMERTSVLEKQVSLER------ERQHDQTHVQSQLE-KLDLLEQEYNKLTTMQALAEKK 209
AE +++ ++ LE ER D+ + ++L K LE E ++L +K
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL-------KKD 957
Query: 210 MQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEK 269
+ +LE L + E+E+ + K L E+ A A+ K+KK+
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLT----------EEMAGLDETIAKLTKEKKA----- 1002
Query: 270 KSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLV--LHLMKQHSKALCNDRVI 327
Q ++ L D+ K + + A Q V L + K LC D
Sbjct: 1003 --------LQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD--- 1051
Query: 328 NSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQDEFGQMSFDHQQLAKLIQE 387
L + G K + + ++L+E L+ + F+ L I++
Sbjct: 1052 ----LERAKRKLEGDLKLAQESTMDTENDKQQLNEKLK-------KKEFEMSNLQGKIED 1100
Query: 388 SPTVELKDKLECELEALVGRMEAKANQITKVRKYQAQLEKQKLEKQKKELKATKKTLDEE 447
+ + +L+ +++ L R+E +I R +A+ EKQ+ + +EL+ + L+E
Sbjct: 1101 EQALAI--QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD-LSRELEEISERLEEA 1157
Query: 448 RNSSSRSGITGTTNKKDFMKLR 469
++S + +F K+R
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMR 1179
Score = 44.3 bits (103), Expect = 3e-04
Identities = 87/437 (19%), Positives = 173/437 (39%), Gaps = 30/437 (6%)
Query: 79 KIRR-LELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL--LA 135
K+RR LE +Q E + L ++ + L EQI + K + K EL ++ LA
Sbjct: 1177 KMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLA 1236
Query: 136 A------------ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQ 183
+ E C LE QL ++ K E +R L ++S ++ R H ++
Sbjct: 1237 SNMETVSKAKANFEKMCRTLEDQLSEIKT--KEEEQQR---LINELSAQKARLHTESGEF 1291
Query: 184 SQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRL 243
S+ +LD + ++L+ + ++++EL+ +L EE + + + + + R
Sbjct: 1292 SR--QLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLRE 1349
Query: 244 IFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAV 303
+E++ R + K S+ + ++ Q L + H
Sbjct: 1350 QYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 304 VANVQLV-LHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSE 362
N + L KQ + D +I+ + K + EE
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQA 1469
Query: 363 VLQTLQDEFGQMSFDHQQLAKLIQES----PTVELKDK-LECELEALVGRMEAKANQITK 417
L+ Q E +S + ++ +ES T++ ++K L+ E+ L ++ I +
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHE 1529
Query: 418 VRKYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKN 477
+ K + QL+ +K E Q L+ + +L+ E R + K + + + EK +
Sbjct: 1530 LEKVKKQLDHEKSELQ-TSLEEAEASLEHEEGKILRIQLELNQVKSEIDR-KIAEKDEEL 1587
Query: 478 LQLLKDMQSIQNSLQSS 494
QL ++ + S+QS+
Sbjct: 1588 DQLKRNHLRVVESMQST 1604
Score = 38.5 bits (88), Expect = 0.014
Identities = 43/220 (19%), Positives = 94/220 (42%), Gaps = 17/220 (7%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEE 122
E R A + L D R++L Q + T + + ++ E + ++N E
Sbjct: 1697 ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE 1756
Query: 123 SKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHV 182
K + +T + AE L+K+ + ++ + + +V + Q+ L+ Q
Sbjct: 1757 EKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGG 1812
Query: 183 QSQLEKLDLL----------EQEYNKLTTMQALA--EKKMQELEAKLHEEEQERKRMQAK 230
+ Q++KL+ EQ++N + ++ L E++++EL + E+ + R+Q
Sbjct: 1813 KKQIQKLEARVRELESEVESEQKHN-VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1871
Query: 231 AAELQTGLETNRLIFEDKATPCVPNARRIKKKKSKPPEKK 270
+LQT ++ + E+ N + +K + + E K
Sbjct: 1872 VDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK 1911
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 58.5 bits (140), Expect = 1e-08
Identities = 43/209 (20%), Positives = 94/209 (44%), Gaps = 15/209 (7%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQLLAA 136
++K+RRLE + EE ++ L + E +K+ +++ + +E K E + QE +++
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 137 ENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEY 196
E K + +Q E +R K + + E++ E E++ +Q + Q EK+ E+ +
Sbjct: 422 EEK---IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 478
Query: 197 NKLTTMQALA------------EKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244
+ M E+KM + E K+ E+E++ R + K E + +
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK 538
Query: 245 FEDKATPCVPNARRIKKKKSKPPEKKSSR 273
++ ++ +++ K E++ R
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Score = 52.4 bits (124), Expect = 1e-06
Identities = 70/393 (17%), Positives = 165/393 (41%), Gaps = 42/393 (10%)
Query: 76 LQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERE---------------NSKN 120
LQ+K++ +E E+ + + +VK L R+ K +L +Q + E ++
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285
Query: 121 EES----KHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQ 176
EE+ + NQ+ ++ E K E++++ I+ E + EK E
Sbjct: 286 EENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345
Query: 177 HDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQT 236
+ ++ Q E + E++ +L M E+K++ELE K+HE+E+ R++ + + E +
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 405
Query: 237 GLETNRLIFEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKS 296
+ R E K R +++K + EKK R ++ + +
Sbjct: 406 REQEKRQEQEAKMWRQEEKIRE-QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 297 TSPSHAVVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGI 356
+ ++ K H + + KQ + +K+
Sbjct: 465 WRQEEKIREQEEIWRQKEKMHEQE----------KIRKQEEKVWRQEEKM---------- 504
Query: 357 NEELSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQIT 416
+++ ++ + + + Q +Q K+ ++ + ++++ E E +G E K +
Sbjct: 505 HDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQE 564
Query: 417 KVRKYQAQLEKQ--KLEKQKKELKATKKTLDEE 447
K+R+ + ++ +Q K+ +QK++++ ++ + E+
Sbjct: 565 KMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ 597
Score = 48.9 bits (115), Expect = 1e-05
Identities = 36/181 (19%), Positives = 84/181 (46%), Gaps = 11/181 (6%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSK--- 119
E R + + ++KIR LE E++ +E ++ + E +K+ +++ ++ + +K
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 420
Query: 120 -----NEESKHNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSL--E 172
E+ + +E ++ E K + EK E + + + + +Q + +
Sbjct: 421 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 480
Query: 173 RERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAA 232
+E+ H+Q ++ Q EK+ E++ + E+KM E K+ E+E++ + + K
Sbjct: 481 KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIR 540
Query: 233 E 233
E
Sbjct: 541 E 541
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/167 (23%), Positives = 78/167 (46%), Gaps = 7/167 (4%)
Query: 73 LKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQ 132
++ ++K+ R E + EE + RE E +E+I+E+E E+ + +E
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKI----REQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 133 LLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH-VQSQLEKLDL 191
+ E K E++++ M + E R E+++ ++E+ +Q + Q EK+
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ--EEKIREQKEKIREQEEKIWEQEEKIRE 603
Query: 192 LEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGL 238
E+ + E+KM E E K+ E+E++ +R + K E + L
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650
Score = 46.2 bits (108), Expect = 7e-05
Identities = 45/197 (22%), Positives = 83/197 (42%), Gaps = 31/197 (15%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVL---DEQIQERENSKNEESKHNQELTSQL 133
Q+K + E + + EE ++ + E +K + +E+I E+E + EE + QE ++
Sbjct: 408 QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE---EM 464
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH------------ 181
E K + +Q E R K E E+ E++V + E+ HDQ
Sbjct: 465 WRQEEK---IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQ 521
Query: 182 ----------VQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKA 231
++ Q EK+ E+ + E+KMQE E +EE+ R++ +
Sbjct: 522 EEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIR 581
Query: 232 AELQTGLETNRLIFEDK 248
+ + E I+E +
Sbjct: 582 EQKEKIREQEEKIWEQE 598
Score = 46.2 bits (108), Expect = 7e-05
Identities = 36/155 (23%), Positives = 71/155 (45%), Gaps = 4/155 (2%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQ---IQERENSKNEESKHNQELTSQL 133
++KIR E + + EE ++ + E ++ + EQ +QE+E E+ + QE ++
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE-QEKM 566
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
E K E+++ + I+ E + EK E Q + + Q EK+ E
Sbjct: 567 RRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 626
Query: 194 QEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQ 228
++ + E+KM E E +L ++E++ + Q
Sbjct: 627 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 43.5 bits (101), Expect = 4e-04
Identities = 35/177 (19%), Positives = 87/177 (49%), Gaps = 13/177 (7%)
Query: 77 QDKIRRLELERIQAEESVKTLSRETIEYKKVL---DEQIQERENSKNEESKHNQELTSQL 133
Q+KIR+ E + + EE + + E ++ + +E+I+E+E E+ + +E +
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMM 546
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTH-VQSQLEKL--- 189
E K E++++ M + E R E+++ ++E+ +Q + Q EK+
Sbjct: 547 QEQEEKMGEQEEKMQEQEKMRRQEEKIREQ--EEKIREQKEKIREQEEKIWEQEEKIREQ 604
Query: 190 -DLLEQEYNKLTTMQALA---EKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNR 242
++++++ K+ + E+KMQE E K+ +E++ + + + + ++ ++
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Score = 40.0 bits (92), Expect = 0.005
Identities = 34/168 (20%), Positives = 78/168 (46%), Gaps = 14/168 (8%)
Query: 77 QDKIRRLE-----LERIQAEESVKTLSRETIEYKKVL---DEQIQERENSKNEESKHNQE 128
++KIR E E++ +E ++ + ++ + +E+I+E+E + + +E
Sbjct: 468 EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIRE 527
Query: 129 LTSQLLAAENKCNLLEKQLEYMRNMI-----KHAEMERTSVLEKQVSLERERQHDQTH-V 182
++ E K E+ ++ + K E E+ E+++ + E+ +Q +
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587
Query: 183 QSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAK 230
+ Q EK+ E++ + M E+KM E E K+ E+E++ + + K
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 635
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 58.5 bits (140), Expect = 1e-08
Identities = 102/494 (20%), Positives = 192/494 (38%), Gaps = 96/494 (19%)
Query: 63 ESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQ--------- 113
E R S L ++ +R +L+R + + L E K+ L+E+
Sbjct: 1457 EKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKV 1516
Query: 114 -----ERENSKNEESKHNQELTS---QLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVL 165
E ++ ++ESK L QL E K E++L+ I+ E + L
Sbjct: 1517 VSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK---L 1573
Query: 166 EKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERK 225
++ +ER RQ ++S+ E+++ Q +KK++++E +L EE ++++
Sbjct: 1574 RLEMEMERMRQTHSKEMESRDEEVEEARQS----------CQKKLKQMEVQLEEEYEDKQ 1623
Query: 226 RMQAKAAELQTGLET-----NRLIFE-----------------------DKATPCVPNAR 257
++ + EL+ L T NR FE D P+ R
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKR 1683
Query: 258 RIKKKKSKPPEKK-SSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLHLMKQ 316
I + K++ E + + A+ + + D+ A+ + + +
Sbjct: 1684 EIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 317 HSKALCNDRVINSIPLAK------QVSSRGGKSKKLSVTPPSSNGINEELSEVLQTLQD- 369
L D+ + + K Q S + L +N +EL E LQ LQ
Sbjct: 1744 IQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQ 1803
Query: 370 -EFGQMSFDHQQLAKLIQESPTVELKDKLECE------LEALVGRMEAKANQITKVRKYQ 422
EF + S + L QE+ EL+ +LE E LE+L R++ ++T+ R +
Sbjct: 1804 VEFLEQSMVDKSLVSR-QEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR 1862
Query: 423 AQLEKQKLEKQK---KELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRKNLQ 479
E ++ E+ K ++L+ TK+ + E + + E RK +
Sbjct: 1863 IAAENREKEQNKRLQRQLRDTKEEMGE-------------------LARKEAEASRKKHE 1903
Query: 480 LLKDMQSIQNSLQS 493
L D++S++ + QS
Sbjct: 1904 LEMDLESLEAANQS 1917
Score = 55.8 bits (133), Expect = 9e-08
Identities = 89/434 (20%), Positives = 191/434 (44%), Gaps = 53/434 (12%)
Query: 76 LQDKIRRLELERIQAEESVKT--LSRETIEYKKVLDEQIQERENSKNEESKHNQELTSQL 133
L+ K RR + E QA E + L RE ++ +K D + E + K + + + ++
Sbjct: 1456 LEKKQRRFDSELSQAHEEAQREKLQREKLQREK--DMLLAEAFSLKQQLEEKDMDIAG-- 1511
Query: 134 LAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQSQLEKLDLLE 193
K LE +L+ + + E V ++ LE + + + + Q + +LE
Sbjct: 1512 --FTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLE 1569
Query: 194 QEYNKLTT-MQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFEDKATPC 252
Q +L M+ + + +E+E++ E E+ R+ Q K +++ LE +EDK
Sbjct: 1570 QAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEE---YEDKQK-- 1624
Query: 253 VPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANVQLVLH 312
V +R + K + +R F ++ R K + A++A+ QL+L
Sbjct: 1625 VLREKRELEGKLATLSDQVNRRDFESEKRLR-----------KDLKRTKALLADAQLML- 1672
Query: 313 LMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSS----NGINEELSEVLQTLQ 368
D + NS P ++++ + ++ T ++ + E+ ++ +
Sbjct: 1673 -----------DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQID 1721
Query: 369 DEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRME------AKANQ-ITKVRKY 421
D + +QL++L +E E++++LE + E + M+ A+A++ + ++
Sbjct: 1722 DIAKAKTALEEQLSRLQREKN--EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDL 1779
Query: 422 QAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNKKDFMKLRPGEKRRK-NLQL 480
QAQLE+ K+K+EL+ + L + +S + + + K+R E R +
Sbjct: 1780 QAQLEE--ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ 1837
Query: 481 LKDMQSIQNSLQSS 494
+K ++S+ + L+ +
Sbjct: 1838 VKRLESLASRLKEN 1851
Score = 54.7 bits (130), Expect = 2e-07
Identities = 93/470 (19%), Positives = 193/470 (41%), Gaps = 93/470 (19%)
Query: 73 LKNLQDKIRRL--ELERIQAEESVKTLSRETIEYK-KVLDEQIQERENSKNEESKHNQEL 129
++N ++I++L +LE+ + E + L+ + +E + L ++ + N+ S+
Sbjct: 1256 IRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAE 1315
Query: 130 TSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSV-LEKQVSLERERQHDQTHVQSQLEK 188
T++ L AE + L+ Q + ++ ++ EME L + + E D + +L+
Sbjct: 1316 TAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLK- 1374
Query: 189 LDLLEQEYNKLTTMQALAEKKMQ-ELEAKLHEEEQERKRMQAKAAELQTGLETNRLIFED 247
Y + +K++Q E E KL E+Q +++++ + +LQ E ++ +
Sbjct: 1375 -------YERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQ 1427
Query: 248 KATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLCLGDMPFVAGKSTSPSHAVVANV 307
C ++ K E + RN+ + R S +H
Sbjct: 1428 LKKKCQRLTAELQDTKLH-LEGQQVRNHELEKKQRRF---------DSELSQAHEEAQRE 1477
Query: 308 QLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSNGINEELSEVLQTL 367
+L +++ L + + L +Q+ + K + + G +++ + L
Sbjct: 1478 KLQREKLQREKDML----LAEAFSLKQQL-----EEKDMDIA-----GFTQKVVSLEAEL 1523
Query: 368 QDEFGQMSFDHQQLAK------------------LIQESPTVELKDKLECELEALVGRM- 408
QD Q S D LAK L +++ T+++ ++ + LE + RM
Sbjct: 1524 QDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMR 1583
Query: 409 ---------------EAKANQITKVRKYQAQLE-----KQKLEKQKKELKATKKTLDEER 448
EA+ + K+++ + QLE KQK+ ++K+EL+ TL ++
Sbjct: 1584 QTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQ- 1642
Query: 449 NSSSRSGITGTTNKKDF---MKLRPGEKRRKNLQLLKDMQSIQNSLQSSS 495
N++DF +LR KR K LL D Q + + L++S+
Sbjct: 1643 -----------VNRRDFESEKRLRKDLKRTK--ALLADAQLMLDHLKNSA 1679
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/208 (24%), Positives = 100/208 (48%), Gaps = 22/208 (10%)
Query: 46 LNSDLRRSPSKPTLAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYK 105
L DL+R+ K LA +++ + LKN R + + Q EES T + ++ +
Sbjct: 1654 LRKDLKRT--KALLA----DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAA-AVKAR 1706
Query: 106 KVLDEQIQERENSKNEESKHNQELTSQLLAAENKCNLLEKQLEYMRN-----MIKH---- 156
K ++ +I++ ++ +K L QL + + N ++ +LE + M KH
Sbjct: 1707 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAV 1766
Query: 157 --AEMERTSVLEKQVSLE---RERQHDQTHVQSQLEKLDLLEQEYNKLTTMQALAEKKMQ 211
A + + + Q LE +E+Q Q +Q+ +++ LEQ ++ + E K++
Sbjct: 1767 AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD-KSLVSRQEAKIR 1825
Query: 212 ELEAKLHEEEQERKRMQAKAAELQTGLE 239
ELE +L E + KR+++ A+ L+ +E
Sbjct: 1826 ELETRLEFERTQVKRLESLASRLKENME 1853
Score = 40.8 bits (94), Expect = 0.003
Identities = 51/215 (23%), Positives = 86/215 (40%), Gaps = 44/215 (20%)
Query: 69 IFSALKNLQDKIRRLELERIQA----EESVKTLSRETIEYKKVLDE------QIQERENS 118
I A L++++ RL+ E+ + EE + ++ ++K + + QI + +
Sbjct: 1723 IAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQ 1782
Query: 119 KNEESKHNQELTSQLLAAENKCNLLE----------KQLEYMRNMIKHAEMERTSV--LE 166
E +K QEL +L A +++ LE +Q +R + E ERT V LE
Sbjct: 1783 LEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLE 1842
Query: 167 KQVSLERERQHDQTHVQSQLEKLDLLEQEYNK---------------LTTMQALAEKKMQ 211
S +E T + Q + E+E NK L +A A +K
Sbjct: 1843 SLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKH 1902
Query: 212 ELEAKLHEEEQERKRMQA-------KAAELQTGLE 239
ELE L E + +QA + +LQ +E
Sbjct: 1903 ELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIE 1937
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.123 0.327
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,298,449
Number of Sequences: 37866
Number of extensions: 776452
Number of successful extensions: 11696
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 349
Number of HSP's successfully gapped in prelim test: 887
Number of HSP's that attempted gapping in prelim test: 5436
Number of HSP's gapped (non-prelim): 4733
length of query: 500
length of database: 18,247,518
effective HSP length: 106
effective length of query: 394
effective length of database: 14,233,722
effective search space: 5608086468
effective search space used: 5608086468
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.