Search of human proteins with 45267826

Search of human proteins with 45267826

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide
1 [Homo sapiens]
         (501 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...  1026   0.0  
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   401   e-112
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   378   e-105
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   330   2e-90
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   327   1e-89
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   311   9e-85
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   311   9e-85
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   308   1e-83
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   301   9e-82
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   300   3e-81
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   298   6e-81
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   297   1e-80
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   295   9e-80
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   293   2e-79
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   292   4e-79
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   286   4e-77
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   260   2e-69
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   258   7e-69
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   251   1e-66
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   220   2e-57
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   216   5e-56
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   213   3e-55
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  213   3e-55
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   182   8e-46
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   159   4e-39
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   127   2e-29
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   124   2e-28
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   119   5e-27
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   114   2e-25
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        112   8e-25

>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score = 1026 bits (2653), Expect = 0.0
 Identities = 501/501 (100%), Positives = 501/501 (100%)

Query: 1   MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE 60
           MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE
Sbjct: 1   MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE 60

Query: 61  LPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTK 120
           LPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTK
Sbjct: 61  LPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTK 120

Query: 121 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180
           MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK
Sbjct: 121 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 180

Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240
           QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF
Sbjct: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 240

Query: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300
           GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL
Sbjct: 241 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 300

Query: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360
           IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY
Sbjct: 301 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 360

Query: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420
           TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF
Sbjct: 361 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 420

Query: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD 480
           HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD
Sbjct: 421 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD 480

Query: 481 LKPRLGMTLQPQPYLICAERR 501
           LKPRLGMTLQPQPYLICAERR
Sbjct: 481 LKPRLGMTLQPQPYLICAERR 501


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  401 bits (1031), Expect = e-112
 Identities = 214/495 (43%), Positives = 303/495 (61%), Gaps = 8/495 (1%)

Query: 4   LWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPH 63
           LW        L G +  LL A      LK+RRP  +PPGP  LPF+GN + +    E  H
Sbjct: 12  LWAVVHPRTLLLGTVAFLLAA----DFLKRRRPKNYPPGPWRLPFLGNFFLV--DFEQSH 65

Query: 64  VYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGG 123
           + ++   + YG +FSL+LG IS V++ G  ++KE L+H  + F +RP  P+   + K  G
Sbjct: 66  LEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNG 125

Query: 124 LLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLI 183
           L+ S  G+ W + RR  + + R FG G+KS E +I EE +   +AI+   G+PFD    I
Sbjct: 126 LIMSS-GQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI 184

Query: 184 TNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKH 243
            NAVSNI   I FGERF Y+D+ FQ +++L  E   L AS +  LYN FPWI     G H
Sbjct: 185 NNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH 244

Query: 244 QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFS 303
           Q LF N   +  F+S +I+K   +  P   + F+DAYL EM +   +P+S+F +ENLI S
Sbjct: 245 QTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICS 304

Query: 304 VGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEA 363
             +L  AGTETT+  LRWA+L+MALYP IQ +VQ EID ++G   +PS   +  MPYT A
Sbjct: 305 TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNA 364

Query: 364 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPE 423
           V+HEV R  NI+PL +    + D  + GY +PKGT ++TNL ++H D   W  P+ F+P+
Sbjct: 365 VIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424

Query: 424 RFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKP 483
            FL+ +G F K+EA +PFS+G+R CLGE LAR E+F+FFT+L+Q+F    P+     LK 
Sbjct: 425 HFLE-NGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKF 483

Query: 484 RLGMTLQPQPYLICA 498
           R+G+T+ P  + +CA
Sbjct: 484 RMGITISPVSHRLCA 498


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  378 bits (971), Expect = e-105
 Identities = 210/526 (39%), Positives = 307/526 (58%), Gaps = 27/526 (5%)

Query: 3   KLWRAEEGAAAL---GGALFLL-LFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAAS 58
           +L RA  G   L   GGAL L  L AL     L++RR  G PPGP   P +GN   +   
Sbjct: 19  RLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLP 78

Query: 59  SEL---------------------PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKE 97
             L                     P V +   ++VYG IFS  +G    VVL+ +  V+E
Sbjct: 79  PFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVRE 138

Query: 98  CLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157
            LV Q+E+F+DRP +PL   +TK  G++ + YG  W   R+ + ++ R+FG G+ S E K
Sbjct: 139 ALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPK 198

Query: 158 ILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217
           I+EE K+    ++ +   PF    +I+NAVSNI   + FG+RF Y +++F+ M+   S  
Sbjct: 199 IIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRG 258

Query: 218 VELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277
           +E+  ++ V L N  PW+  LPFG  ++L +    +  FL ++I+    +   + PQ F+
Sbjct: 259 LEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFI 318

Query: 278 DAYLDEMDQG-KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336
           D YL  M++  KN+ +S+F +E L + +G+L IAGT+TTTN L W +L+M+L P++Q +V
Sbjct: 319 DMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKV 378

Query: 337 QKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPK 396
            +EI+ ++G N  PS  DK +MPYTEA + EV R   +VPL I H TSE+ V++GY+IPK
Sbjct: 379 HEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPK 438

Query: 397 GTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARM 456
           GT ++ NL+SVH D   W  PE F+P RFLD  G   KKE  +PF +G+R C+GE LA+M
Sbjct: 439 GTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKM 498

Query: 457 EMFLFFTALLQRFHLHFPHE-LVPDLKPRLGMTLQPQPYLICAERR 501
           E+FL F +L+Q F    P +   P L  R G+TL P P+ I   RR
Sbjct: 499 ELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR 544


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  330 bits (846), Expect = 2e-90
 Identities = 196/489 (40%), Positives = 274/489 (56%), Gaps = 9/489 (1%)

Query: 17  ALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76
           A+FLLL  L  R   +QR    +PPGP  LP +GN+  +   +  P+ + + + + +G++
Sbjct: 14  AIFLLLVDLMHR---RQRWAARYPPGPLPLPGLGNLLHVDFQNT-PYCFDQLRRR-FGDV 68

Query: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM---TKMGGLLNSRYGRGW 133
           FSL L     VVLNG   V+E LV   E  ADRP +P+   +    +  G+  +RYG  W
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128

Query: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193
            + RR +V++ R  G G+KS E  + EE      A   + GRPF    L+  AVSN+   
Sbjct: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188

Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253
           +  G RF Y+D  F  +++L  E ++  +     + NA P +  +P    + L    A +
Sbjct: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFL 248

Query: 254 YDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTE 313
                 L E        Q P+   +A+L EM++ K +P S+F+ ENL   V +L  AG  
Sbjct: 249 TQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMV 308

Query: 314 TTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCN 373
           TT+  L W +L M L+P++Q +VQ+EID ++G   +P   D+  MPYT AV+HEV RF +
Sbjct: 309 TTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGD 368

Query: 374 IVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA 433
           IVPLG+ H TS D  V+G+ IPKGTT+ITNL SV  DE  W  P  FHPE FLD+ G+F 
Sbjct: 369 IVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV 428

Query: 434 KKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP-HELVPDLKPRLGMTLQPQ 492
           K EA +PFS GRR CLGE LARME+FLFFT+LLQ F    P  +  P         + P 
Sbjct: 429 KPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPS 488

Query: 493 PYLICAERR 501
           PY +CA  R
Sbjct: 489 PYELCAVPR 497


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  327 bits (839), Expect = 1e-89
 Identities = 187/494 (37%), Positives = 278/494 (56%), Gaps = 10/494 (2%)

Query: 13  ALGGALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71
           ++  A+ LLL AL    L    R  G  PPGP  L  +GN+  L +   L    + K S+
Sbjct: 3   SISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTS--LTKLSK 60

Query: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGR 131
            YG ++++ LG    VVL+GY  VKE LV Q E F+ R   P F   TK  G+  S  G 
Sbjct: 61  EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSS-GD 119

Query: 132 GWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNIT 191
            W   R+ ++   R FG G++S E +ILEE  F    +   +G PFD   +++ +VSNI 
Sbjct: 120 RWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNII 179

Query: 192 NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAA 251
             ++FG RF Y+D     +I L ++N ++ +S    LY+ FP +     G HQ++F+N  
Sbjct: 180 CSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFK 239

Query: 252 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311
            + D ++  +     +  P+ P+ F+  +L +M + K DP S F  + L+ +   L+  G
Sbjct: 240 CLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGG 299

Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371
           T+T +  L  A L +  YP +Q +VQ+EIDL++G    P+  D+  MPYT+AV+HEV RF
Sbjct: 300 TKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRF 359

Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431
            +I+P+ + H  + D   RG+ IPKGT VIT L +VH+D   +  P+ F+PE FLD++  
Sbjct: 360 ADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQS 419

Query: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH---FPHELVPDLKP-RLGM 487
           F K  A +PFS GRR CLGE LARME+FL+ TA+LQ F L     P ++  DL P   G+
Sbjct: 420 FKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDI--DLTPLSSGL 477

Query: 488 TLQPQPYLICAERR 501
              P+P+ +C   R
Sbjct: 478 GNLPRPFQLCLRPR 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  311 bits (797), Expect = 9e-85
 Identities = 178/488 (36%), Positives = 277/488 (56%), Gaps = 9/488 (1%)

Query: 13  ALGGALFLLLFALGVRQLL---KQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRK 68
           A G  L  LL  L V  L+   +QR+  G  PPGP  LPFIGN   L  ++E  +  + K
Sbjct: 3   ASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQL--NTEQMYNSLMK 60

Query: 69  QSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR 128
            S+ YG +F++ LG    VVL G+D VKE LV Q+E F+ R     F  + K  G+  S 
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120

Query: 129 YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS 188
            G      RR ++ + R FG G++  E +I EE  F  DA+    G   D    ++  VS
Sbjct: 121 -GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVS 179

Query: 189 NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFR 248
           N+ + I+FG+RF YED +F  ++ +   + +  A+++  LY  F  +     G  QQ F+
Sbjct: 180 NVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFK 239

Query: 249 NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI 308
               + DF+++ +E       P  P+ F+D++L  M + + +P++ F  +NL+ +   L 
Sbjct: 240 ELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLF 299

Query: 309 IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 368
            AGTET +  LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPYTEAV+HE+
Sbjct: 300 FAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEI 359

Query: 369 LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 428
            RF +++P+G+ H  ++D   R + +PKGT V   L SV  D +++ +P  F+P+ FLD 
Sbjct: 360 QRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDK 419

Query: 429 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP-DLKPR-LG 486
            G F K +A VPFS+G+R+C GE LARME+FLFFT ++Q F    P      D+ P+ +G
Sbjct: 420 KGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVG 479

Query: 487 MTLQPQPY 494
               P+ Y
Sbjct: 480 FATIPRNY 487


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  311 bits (797), Expect = 9e-85
 Identities = 191/498 (38%), Positives = 283/498 (56%), Gaps = 23/498 (4%)

Query: 17  ALFLLLFA--LGVRQLL----KQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQ 69
           AL LLLF   LG+  LL    +   P   +PPGP  LP +GN++ L  S +     + + 
Sbjct: 2   ALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQ--DRSLMEL 59

Query: 70  SQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRY 129
           S+ YG +F++ LG   TVVL G++ VKE L    +  ADRP + +F  + + GG+  S  
Sbjct: 60  SERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSS- 118

Query: 130 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 189
           G  W   R+  V +    G G++    KIL+E K  +  ++ Y+GRPF    L+  A SN
Sbjct: 119 GARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLA-LLGWAPSN 177

Query: 190 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN 249
           IT  ++FG RF Y D  F  ++ L  E + L  S  + L+N +PW+G L    H+ + R 
Sbjct: 178 ITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGAL-LQLHRPVLRK 236

Query: 250 AAVVYDFLSRLIEKASVNRKPQL-PQHFVDAYLDEM-DQGK-NDPSSTFSKENLIFSVGE 306
              V   L  L+E     R+P + P   V +Y+D +  QG+ +DP   F++ N +    +
Sbjct: 237 IEEVRAILRTLLEA----RRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLD 292

Query: 307 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLH 366
           +++AGTETT+  L+WA L M  +P++QG+VQ+E+D ++GP   P  +D+  +PYT AVLH
Sbjct: 293 MVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLH 352

Query: 367 EVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFL 426
           EV RF  ++P  +   T+ D  + G+ +PKGT VI  L SV  DE  W+ P  F+P  FL
Sbjct: 353 EVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFL 411

Query: 427 DSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVP---DLKP 483
           D++G+F K+EA +PFS GRR C+GE LAR E+FL F  LLQR+ L  P  + P   D  P
Sbjct: 412 DANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP 471

Query: 484 RLGMTLQPQPYLICAERR 501
               T++P+   +CA  R
Sbjct: 472 ARAFTMRPRAQALCAVPR 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  308 bits (788), Expect = 1e-83
 Identities = 172/485 (35%), Positives = 277/485 (57%), Gaps = 17/485 (3%)

Query: 19  FLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFS 78
           F+LLF+L  RQ  ++R+    PPGP  LP IGN+  +              S+VYG +F+
Sbjct: 13  FMLLFSLW-RQSCRRRK---LPPGPTPLPIIGNMLQIDVKDICKS--FTNFSKVYGPVFT 66

Query: 79  LDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR 138
           +  G    VV +GY+ VKE L+   E F+ R   P+  ++TK  G+++S  G+ W + RR
Sbjct: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN-GKRWKEIRR 125

Query: 139 LAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGE 198
            ++ + R FG G++S E ++ EE     + +   K  P D   ++  A  N+   ++F +
Sbjct: 126 FSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQK 185

Query: 199 RFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLS 258
           RF Y+D +F  +++ F+EN  +  S  + + N FP +     G H ++ +N A+   ++ 
Sbjct: 186 RFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIR 245

Query: 259 RLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNV 318
             +++   +     P+ F+D +L +M+Q K++  S F+ ENL+ +V +L +AGTETT+  
Sbjct: 246 EKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTT 305

Query: 319 LRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLG 378
           LR+ +L +  +P +  +VQ+EID ++G +  P   D+  MPYT+AV+HE+ R+ ++VP G
Sbjct: 306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG 365

Query: 379 IFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL 438
           + HA + D   R Y IPKGTT++  L SV  D+K + +P +F P  FLD +G F K +  
Sbjct: 366 VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYF 425

Query: 439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLK------PRLGMTLQPQ 492
           +PFS G+R C GE LARME+FLF T +LQ F+L    + V DLK         G+   P 
Sbjct: 426 MPFSAGKRICAGEGLARMELFLFLTTILQNFNL----KSVDDLKNLNTTAVTKGIVSLPP 481

Query: 493 PYLIC 497
            Y IC
Sbjct: 482 SYQIC 486


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  301 bits (771), Expect = 9e-82
 Identities = 178/494 (36%), Positives = 279/494 (56%), Gaps = 15/494 (3%)

Query: 12  AALGGALFLLLFA---LGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRK 68
           +ALG  + LL++A   L V    +       PPGP  LP IGN++ L   + +P  + R 
Sbjct: 2   SALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKN-IPKSFTRL 60

Query: 69  QSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR 128
            +Q +G +F+L +G    VV++GY  VKE L+   + F+ R  LP F      G + N+ 
Sbjct: 61  -AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNN- 118

Query: 129 YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS 188
            G  W D RR ++ + R +G G++  ES+I  E  F  +A+   +G+PFD   LI  A  
Sbjct: 119 -GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPC 177

Query: 189 NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLF 247
           N+   I+F + F Y D  F  ++ LF+EN  L ++  + LYN FP ++  LP G H+++ 
Sbjct: 178 NVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP-GSHRKVI 236

Query: 248 RNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGEL 307
           +N A V +++S  +++   +  P  P+   D  L EM++ K+     ++ + +  +V +L
Sbjct: 237 KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADL 296

Query: 308 IIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHE 367
             AGTETT+  LR+ +L +  YP I+ ++ +EID ++GP+  P+  D+ +MPY +AV+HE
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHE 356

Query: 368 VLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLD 427
           + RF  +VP  + H  + D + RGY IPKGT V+  L SV +D + + DPE F PE FL+
Sbjct: 357 IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLN 416

Query: 428 SSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH---FPHELVPDLKP- 483
            +G F   +   PFS G+R C GE LARME+FL   A+LQ F+L     P ++  DL P 
Sbjct: 417 ENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI--DLSPI 474

Query: 484 RLGMTLQPQPYLIC 497
            +G    P  Y +C
Sbjct: 475 HIGFGCIPPRYKLC 488


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  300 bits (767), Expect = 3e-81
 Identities = 170/457 (37%), Positives = 265/457 (57%), Gaps = 6/457 (1%)

Query: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75
           AL L L  L +  L +Q    G  P GP  LP IGNI  L          +   S+VYG 
Sbjct: 6   ALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKS--LTNFSKVYGP 63

Query: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135
           +F++  G    VVL+GY+ VKE L+   E F+ R   P+  K+ K  G+L S  G+ W +
Sbjct: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKE 122

Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195
            RR  + + R FG G++S E ++ EE +   + +      P D   ++  A  N+   +I
Sbjct: 123 IRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI 182

Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFP-WIGILPFGKHQQLFRNAAVVY 254
           F +RF Y+D  F +++E F+EN+ + +S  + + N FP  I  LP G H ++  N A + 
Sbjct: 183 FHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLP-GSHNKIAENFAYIK 241

Query: 255 DFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTET 314
            ++   I++   +      + F+D +L +M+Q K++  S F+ E+LI +V ++  AGTET
Sbjct: 242 SYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTET 301

Query: 315 TTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374
           T+  LR+ +L +  YP +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HE+ R+ ++
Sbjct: 302 TSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDL 361

Query: 375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAK 434
           +P  + HA + D   + Y IPKGTT+IT+L SV  ++K + +PE+F P  FLD SG F K
Sbjct: 362 LPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKK 421

Query: 435 KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
            +  +PFS G+R C+GE LARME+FLF T +LQ F+L
Sbjct: 422 SDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  298 bits (764), Expect = 6e-81
 Identities = 166/455 (36%), Positives = 262/455 (57%), Gaps = 4/455 (0%)

Query: 18  LFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76
           L L L  L +  + +Q    G  PPGP  LP IGNI  +          +   S++YG +
Sbjct: 7   LVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKS--LTNLSKIYGPV 64

Query: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136
           F+L  G    VVL+GY+VVKE L+   E F+ R   PL  +  +  G++ S  G+ W + 
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSN-GKRWKEI 123

Query: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196
           RR ++ + R FG G++S E ++ EE +   + +   K  P D   ++  A  N+   IIF
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183

Query: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDF 256
            +RF Y+D  F +++E  +EN+ + ++  + + N FP I     G H +L +N A +   
Sbjct: 184 QKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESD 243

Query: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTT 316
           +   +++   +     P+ F+D +L +M++ K +  S F+ ENL+ +  +L+ AGTETT+
Sbjct: 244 ILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303

Query: 317 NVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVP 376
             LR+A+L +  +P +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HEV R+ +++P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363

Query: 377 LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436
             + HA + D   R Y IPKGTT++T+L SV  D K + +PE+F P  FLD  G F K  
Sbjct: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423

Query: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
             +PFS G+R C+GE LARME+FLF T +LQ F+L
Sbjct: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  297 bits (761), Expect = 1e-80
 Identities = 165/456 (36%), Positives = 258/456 (56%), Gaps = 4/456 (0%)

Query: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75
           AL   L  + +  + +QR+  G  PPGP  LPFIGN   L        +   K S+ YG 
Sbjct: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIM--KFSECYGP 67

Query: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135
           +F++ LG    VVL G+D V+E LV Q+E F+ R     F  + K  G+  S  G     
Sbjct: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN-GERAKQ 126

Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195
             R A+ + R FG G++  E +I EE+ F  +AI +  G   D    ++  VSN+ + I+
Sbjct: 127 LLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIV 186

Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255
           FG+RF YED +F  ++ +     +  ++++  LY  F  +     G  QQ F+    + D
Sbjct: 187 FGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLED 246

Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315
           F+++ +E       P  PQ F+D++L  M + + +P++ F  +NL+ S   L IAGTET 
Sbjct: 247 FIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETV 306

Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375
           +  LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++
Sbjct: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVI 366

Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435
           P+ +     +D   R + +PKGT V   L SV  D  ++ +P+ F+P+ FLD  G F K 
Sbjct: 367 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKS 426

Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
           +A VPFS+G+R+C GE LARME+FLFFT ++Q F L
Sbjct: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 462


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  295 bits (754), Expect = 9e-80
 Identities = 167/483 (34%), Positives = 274/483 (56%), Gaps = 10/483 (2%)

Query: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75
           AL + L  + +  + +QR+  G  PPGP  LPFIGN   L  ++E  +  + K S+ YG 
Sbjct: 10  ALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQL--NTEQMYNSLMKISERYGP 67

Query: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135
           +F++ LG    VVL G+D V+E LV Q+E F+ R     F  + K  G++ S  G     
Sbjct: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN-GERAKQ 126

Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195
            RR ++ + R FG G++  E +I EE  F  DA+    G   D    ++  VSN+ + I+
Sbjct: 127 LRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIV 186

Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255
           FG+RF Y+D +F  ++ +     +  ++++  LY  F  +     G  QQ F+    + D
Sbjct: 187 FGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLED 246

Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315
           F+++ +E       P  P+ F+D++L  M + + +P++ F  +NL+ +   L I GTET 
Sbjct: 247 FIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETV 306

Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375
           +  LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++
Sbjct: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVI 366

Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435
           P+ +     +D   R + +PKGT V   L SV  D  ++ +P+ F+P+ FL+  G F K 
Sbjct: 367 PMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS 426

Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL---HFPHELVPDLKPR-LGMTLQP 491
           +A VPFS+G+R+C GE LARME+FLFFT ++Q F L     P ++  D+ P+ +G    P
Sbjct: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDI--DVSPKHVGFATIP 484

Query: 492 QPY 494
           + Y
Sbjct: 485 RNY 487


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  293 bits (751), Expect = 2e-79
 Identities = 166/462 (35%), Positives = 258/462 (55%), Gaps = 11/462 (2%)

Query: 18  LFLLLFALGVRQLLKQRRPMG---FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYG 74
           LFL L   G+  LL QR P      PPGP  LP +GN+  +     L      ++   YG
Sbjct: 7   LFLALLT-GLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREK--YG 63

Query: 75  EIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWV 134
           ++F++ LG    V+L G + ++E LV ++E F+ R  + +     +  G++ +  G  W 
Sbjct: 64  DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN-GNRWK 122

Query: 135 DHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLI 194
             RR +V + R FG G++S E +I EE +   + +   KG   D   L  +  +NI   I
Sbjct: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182

Query: 195 IFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF--GKHQQLFRNAAV 252
           +FG+RF Y+D +F  M+ LF +   L +S    L+  F   G L +  G H+Q+++N   
Sbjct: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFS--GFLKYFPGAHRQVYKNLQE 240

Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGT 312
           +  ++   +EK      P  P+  +D YL  M++ K++  S FS +NL  +   L  AGT
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query: 313 ETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFC 372
           ETT+  LR+  L M  YP++  +V +EI+ ++GP+  P   D+ KMPYTEAV++E+ RF 
Sbjct: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query: 373 NIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYF 432
           +++P+G+ H  ++    RGY IPK T V   L +   D  Y+  P+ F+P+ FLD++G  
Sbjct: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query: 433 AKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474
            K EA +PFSLG+R CLGE +AR E+FLFFT +LQ F +  P
Sbjct: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  292 bits (748), Expect = 4e-79
 Identities = 167/456 (36%), Positives = 263/456 (57%), Gaps = 6/456 (1%)

Query: 18  LFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76
           L L L  L +  L +Q    G  PPGP  LP IGNI  +          +   S+VYG +
Sbjct: 7   LVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKS--LTNLSKVYGPV 64

Query: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136
           F+L  G    VVL+GY+ VKE L+   E F+ R   PL  +  +  G++ S  G+ W + 
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEI 123

Query: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196
           RR ++ + R FG G++S E ++ EE +   + +   K  P D   ++  A  N+   IIF
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183

Query: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAF-PWIGILPFGKHQQLFRNAAVVYD 255
            +RF Y+D  F +++E  +EN+++ +S  + + N F P I   P G H +L +N A +  
Sbjct: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP-GTHNKLLKNVAFMKS 242

Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315
           ++   +++   +     PQ F+D +L +M++ K++  S F+ E+L  +  +L  AGTETT
Sbjct: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302

Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375
           +  LR+A+L +  +P +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HEV R+ +++
Sbjct: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362

Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435
           P  + HA + D   R Y IPKGTT++ +L SV  D K + +PE+F P  FLD  G F K 
Sbjct: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422

Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
           +  +PFS G+R C+GE LA ME+FLF T++LQ F+L
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  286 bits (731), Expect = 4e-77
 Identities = 182/486 (37%), Positives = 253/486 (52%), Gaps = 54/486 (11%)

Query: 17  ALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76
           A+FLLL  L  R   +QR    +PPGP  LP +GN+  +   +  P+ + + + + +G++
Sbjct: 14  AIFLLLVDLMHR---RQRWAARYPPGPLPLPGLGNLLHVDFQNT-PYCFDQLRRR-FGDV 68

Query: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136
           FSL L     VVLNG   V+E LV   E  ADRP +P+                      
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIT--------------------- 107

Query: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196
                   +  G+G +S                   +GRPF    L+  AVSN+   +  
Sbjct: 108 --------QILGFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTC 140

Query: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDF 256
           G RF Y+D  F  +++L  E ++  +     + NA P +  +P    + L    A +   
Sbjct: 141 GRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQL 200

Query: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTT 316
              L E        Q P+   +A+L EM++ K +P S+F+ ENL   V +L  AG  TT+
Sbjct: 201 DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTS 260

Query: 317 NVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVP 376
             L W +L M L+P++Q +VQ+EID ++G   +P   D+  MPYT AV+HEV RF +IVP
Sbjct: 261 TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP 320

Query: 377 LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436
           LG+ H TS D  V+G+ IPKGTT+ITNL SV  DE  W  P  FHPE FLD+ G+F K E
Sbjct: 321 LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE 380

Query: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP-HELVPDLKPRLGMTLQPQPYL 495
           A +PFS GRR CLGE LARME+FLFFT+LLQ F    P  +  P         + P PY 
Sbjct: 381 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYE 440

Query: 496 ICAERR 501
           +CA  R
Sbjct: 441 LCAVPR 446


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  260 bits (664), Expect = 2e-69
 Identities = 158/456 (34%), Positives = 238/456 (52%), Gaps = 63/456 (13%)

Query: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75
           AL L L  L +  L +Q    G  P GP  LP IGNI  L          +   S+VYG 
Sbjct: 6   ALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKS--LTNFSKVYGP 63

Query: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135
           +F++  G    VVL+GY+ VKE L+   E F+ R   P+  K+ K  G+L S  G+ W +
Sbjct: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKE 122

Query: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195
            RR  + + R FG G++S E ++ EE +   + +      P D   ++  A  N+   +I
Sbjct: 123 IRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI 182

Query: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255
           F +RF Y+D  F +++E F+EN+ + +S         PWI                    
Sbjct: 183 FHDRFDYKDQRFLNLMEKFNENLRILSS---------PWI-------------------- 213

Query: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315
                                         Q K++  S F+ E+LI +V ++  AGTETT
Sbjct: 214 ------------------------------QEKHNQQSEFTVESLIATVTDMFGAGTETT 243

Query: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375
           +  LR+ +L +  YP +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HE+ R+ +++
Sbjct: 244 STTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLL 303

Query: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435
           P  + HA + D   + Y IPKGTT+IT+L SV  ++K + +PE+F P  FLD SG F K 
Sbjct: 304 PTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 363

Query: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
           +  +PFS G+R C+GE LARME+FLF T +LQ F+L
Sbjct: 364 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 399


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  258 bits (660), Expect = 7e-69
 Identities = 164/469 (34%), Positives = 253/469 (53%), Gaps = 11/469 (2%)

Query: 10  GAAALGGALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRK 68
           G  AL  AL LLL    +   L   R  G  PPGP  LP +GN+  L   +   +  + +
Sbjct: 5   GTWALLLALALLLL---LTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGAL--YSGLMR 59

Query: 69  QSQVYGEIFSLDLGGIS-TVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNS 127
            S+ YG +F++ LG     VVL G + V+E L  Q+E F+ R  + +        G+  S
Sbjct: 60  LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS 119

Query: 128 RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAV 187
             G  W   R+  + + R  G G++  E  I  E +   +  +  +GRPFD   L+  A 
Sbjct: 120 N-GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQAT 178

Query: 188 SNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPW-IGILPFGKHQQL 246
           SN+   ++FG RF+YED +FQ ++      +   +S     Y  F W +  LP G H+QL
Sbjct: 179 SNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLP-GPHKQL 237

Query: 247 FRNAAVVYDFLSRLIEKASVNRKPQLP-QHFVDAYLDEMDQGKNDPSSTFSKENLIFSVG 305
             + + +  F  R +++   N     P +  VDA+L +M Q + +P + F+ +N++ +V 
Sbjct: 238 LHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVI 297

Query: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365
            L+ AGT T +  + + +L +  YP++Q  V++E++  +G    PS  D+ ++PYT+AVL
Sbjct: 298 YLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVL 357

Query: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425
           HE  R   +VP+GI          RGY++P+GT V   L S+  D   ++ PE F+P+RF
Sbjct: 358 HEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRF 417

Query: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474
           LD+ G F K EA +PFSLG+R CLGE LA+ E+FLFFT +LQ F L  P
Sbjct: 418 LDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESP 466


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  251 bits (640), Expect = 1e-66
 Identities = 123/334 (36%), Positives = 200/334 (59%)

Query: 138 RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFG 197
           R A+ + R FG G++  E +I EE+ F  +AI +  G   D    ++  VSN+ + I+FG
Sbjct: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137

Query: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257
           +RF YED +F  ++ +     +  ++++  LY  F  +     G  QQ F+    + DF+
Sbjct: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197

Query: 258 SRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTN 317
           ++ +E       P  PQ F+D++L  M + + +P++ F  +NL+ S   L IAGTET + 
Sbjct: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257

Query: 318 VLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPL 377
            LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++P+
Sbjct: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317

Query: 378 GIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEA 437
            +     +D   R + +PKGT V   L SV  D  ++ +P+ F+P+ FLD  G F K +A
Sbjct: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377

Query: 438 LVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471
            VPFS+G+R+C GE LARME+FLFFT ++Q F L
Sbjct: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 411



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 1/40 (2%)

Query: 17 ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSL 55
          AL   L  + +  + +QR+  G  PPGP  LPFIGN   L
Sbjct: 10 ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQL 49


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  220 bits (561), Expect = 2e-57
 Identities = 151/504 (29%), Positives = 244/504 (48%), Gaps = 33/504 (6%)

Query: 18  LFLLLFALGV----RQLLKQRRPM--GFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71
           L LLL  L      ++LL+QRR      PPGP   P IGN    AA  +  H+   + ++
Sbjct: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNA---AAVGQAAHLSFARLAR 79

Query: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGR 131
            YG++F + LG    VVLNG   + + LV Q   FADRP    F  ++    +    Y  
Sbjct: 80  RYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSE 139

Query: 132 GWVDHRRLAVNSFRYFGYGQ----KSFESKILEETKFFNDAIE--TYKGRPFDFKQLITN 185
            W   RR A +  R F   Q    +  E  +L E +     +   +  G   D + L   
Sbjct: 140 HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVV 199

Query: 186 AVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASV-FLYNAFPWIGILP----- 239
           AV+N+ + + FG R++++D +F+   EL S N E   +     L +  PW+   P     
Sbjct: 200 AVANVMSAVCFGCRYSHDDPEFR---ELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRT 256

Query: 240 -FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPS----ST 294
            F + +QL RN +     L + +      R    P+  +DA++   ++     S    + 
Sbjct: 257 VFREFEQLNRNFSNF--ILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGAR 314

Query: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354
              EN+  ++ ++  A  +T +  L+W +L    YP++Q +VQ E+D ++G +  P   D
Sbjct: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374

Query: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414
           +  +PY  A L+E +RF + VP+ I HAT+ +  V GY IPK T V  N +SV+ D   W
Sbjct: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434

Query: 415 RDPEVFHPERFLDSSGYFAK--KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 472
            +PE F P RFLD  G   K     ++ FS+G+R C+GE L++M++FLF + L  +    
Sbjct: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFR 494

Query: 473 FPHELVPDLKPRLGMTLQPQPYLI 496
                   +    G+T++P+ + +
Sbjct: 495 ANPNEPAKMNFSYGLTIKPKSFKV 518


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  216 bits (549), Expect = 5e-56
 Identities = 138/496 (27%), Positives = 246/496 (49%), Gaps = 29/496 (5%)

Query: 14  LGGALFLLLFALGVRQLLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71
           L   +F L+F   V +  + + P G   PPGP G P IG++ +L  +   PH+ + + SQ
Sbjct: 14  LASVIFCLVF--WVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKN---PHLALSRMSQ 68

Query: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL-LNSRYG 130
            YG++  + +G    VVL+G D +++ LV Q + F  RP L  F  ++    +  +   G
Sbjct: 69  QYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSG 128

Query: 131 RGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYKGRPFDFK--Q 181
             W   RRLA N  + F              E  + +E +     ++     P  F   +
Sbjct: 129 PVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYR 188

Query: 182 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 241
            +  +V+N+   I FG R+ +   +   ++ L +   E+  S      N   +I IL + 
Sbjct: 189 YVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG-----NPADFIPILRYL 243

Query: 242 KHQQL--FRNA-AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST--FS 296
            +  L  F++     Y F+ +++++     +    +   D+ ++   + + D ++    S
Sbjct: 244 PNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLS 303

Query: 297 KENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKC 356
            E +I  V +L  AG +T T  + W+++++ + P +Q ++Q+E+D ++G + +P   D+ 
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416
            +PY EA + E  R  + VP  I H+T+ D  ++G+ IPKG  V  N + ++ D+K W +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 417 PEVFHPERFLDSSGYFAK--KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474
           P  F PERFL   G   K   E ++ F +G+R C+GE +AR E+FLF   LLQR     P
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 475 HELVPDLKPRLGMTLQ 490
             +  D+ P  G+T++
Sbjct: 484 LGVKVDMTPIYGLTMK 499


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  213 bits (543), Expect = 3e-55
 Identities = 138/492 (28%), Positives = 235/492 (47%), Gaps = 22/492 (4%)

Query: 14  LGGALFLLLFALGVRQLLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71
           L  A+F L+F   V + L+ R P G   PP P G P +G++ +L  +   PH+ + + SQ
Sbjct: 16  LASAIFCLVF--WVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN---PHLALSRMSQ 70

Query: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL-LNSRYG 130
            YG++  + +G    +VL+  D +++ LV Q + F  RP L     +T    L  ++  G
Sbjct: 71  RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSG 130

Query: 131 RGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYKGRP--FDFKQ 181
             W   RRLA N+   F              E  + +E K     ++     P  FD   
Sbjct: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190

Query: 182 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 241
            +  +V+N+   + FG+ F     +   +++   E VE A+S +   +  FP +  LP  
Sbjct: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDF--FPILRYLPNP 248

Query: 242 KHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI 301
             Q+          FL + +++   +      +    A      +G     +   +E ++
Sbjct: 249 ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIV 308

Query: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYT 361
             V ++  AG +T T  + W+++++   P IQ ++QKE+D ++G   +P   D+ ++PY 
Sbjct: 309 NLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYL 368

Query: 362 EAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFH 421
           EA + E  R  + +P  I H+T+ D  + G+ IPK   V  N + V+ D + W DP  F 
Sbjct: 369 EAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFR 428

Query: 422 PERFLDSSGYFAKK---EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV 478
           PERFL + G    K   E ++ F +G+R C+GE LA+ E+FLF   LLQ+     P  + 
Sbjct: 429 PERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK 488

Query: 479 PDLKPRLGMTLQ 490
            DL P  G+T++
Sbjct: 489 VDLTPIYGLTMK 500


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  213 bits (542), Expect = 3e-55
 Identities = 134/467 (28%), Positives = 242/467 (51%), Gaps = 13/467 (2%)

Query: 20  LLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFS 78
           LLL  L      K+R P   +P     LP +G++  L     + + + + Q + YG I+S
Sbjct: 7   LLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKK-YGPIYS 65

Query: 79  LDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLP-LFMKMTKMGGLLNSRYGRGWVDHR 137
           + +G  +TV++  + + KE L+ + + F+ RP +  L +      G+  +  G  W  HR
Sbjct: 66  VRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHR 125

Query: 138 RLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFG 197
           RLA+ +F  F  G +  E  I +E     D + T+ G+  D    +  AV+N+ +LI F 
Sbjct: 126 RLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFN 185

Query: 198 ERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFL 257
             +   D +  ++I+ ++E + +   +   L +  PW+ I P    ++L  +  +  D L
Sbjct: 186 TSYKNGDPEL-NVIQNYNEGI-IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243

Query: 258 SRLIEKASVNRKPQLPQHFVDAYL------DEMDQGKNDPSSTFSKENLIFSVGELIIAG 311
           ++++E      +     + +D  +      D  + G +  S   S  +++ ++G++  AG
Sbjct: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303

Query: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371
            ETTT+V++W + F+   P ++ ++ +EID  +G +  P+  D+ ++   EA + EVLR 
Sbjct: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363

Query: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSG- 430
             + P+ I H  + D+ +  +++ KGT VI NL+++H +EK W  P+ F PERFL+ +G 
Sbjct: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423

Query: 431 -YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476
              +   + +PF  G R C+GE LAR E+FL    LLQRF L  P +
Sbjct: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  182 bits (461), Expect = 8e-46
 Identities = 151/507 (29%), Positives = 233/507 (45%), Gaps = 48/507 (9%)

Query: 16  GALFLLLFALGVRQLLK--QRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVY 73
           G L LL    G R L    + R +  PP  PG   +          +LP +Y+   +Q +
Sbjct: 5   GLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHL-------LQPDLP-IYLLGLTQKF 56

Query: 74  GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG--GLLNSRYGR 131
           G I+ L LG    VVLN    ++E +V +   FA RP  PL  K+       L    Y  
Sbjct: 57  GPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP-EPLTYKLVSRNYPDLSLGDYSL 115

Query: 132 GWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNIT 191
            W  H++L   S    G  + S E  + + T+ F + +    G P   ++  +    +I 
Sbjct: 116 LWKAHKKLT-RSALLLGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSII 173

Query: 192 NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAA 251
             + FG++   +D       +   E ++  +  S+ + +  P++   P   +  L R   
Sbjct: 174 CYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRR--- 226

Query: 252 VVYDFLSRLIEKASVNRKPQLPQH----FVDAYLDEMD---QGKNDPSSTFSKENLI--- 301
                L + IEK     + QL QH        + D MD   QG   PS       L+   
Sbjct: 227 -----LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH 281

Query: 302 --FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS---WDDKC 356
              +  +L+I GTETT N L WA++F+  +P IQ ++Q+E+D  +GP    S   + D+ 
Sbjct: 282 VHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRA 341

Query: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416
           ++P   A + EVLR   +VPL + H T+  + + GY IP+GT +I NL   H DE  W  
Sbjct: 342 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWER 401

Query: 417 PEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476
           P  F P+RFL+      K    + F  G R CLGE LAR+E+F+  T LLQ F L    +
Sbjct: 402 PHEFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGD 457

Query: 477 LVPDLK--PRLGMTLQPQPYLICAERR 501
            +P L+  P   + L+ QP+ +  + R
Sbjct: 458 ALPSLQPLPHCSVILKMQPFQVRLQPR 484


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  159 bits (403), Expect = 4e-39
 Identities = 142/505 (28%), Positives = 220/505 (43%), Gaps = 74/505 (14%)

Query: 16  GALFLLLFALGVRQLLK--QRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVY 73
           G L LL    G R L    + R +  PP  PG   +          +LP +Y+   +Q +
Sbjct: 5   GLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHL-------LQPDLP-IYLLGLTQKF 56

Query: 74  GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW 133
           G I+ L LG    +V   Y                 P L L              Y   W
Sbjct: 57  GPIYRLHLGLQDKLVSRNY-----------------PDLSL------------GDYSLLW 87

Query: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193
             H++L   S    G  + S E  + + T+ F + +    G P   ++  +    +I   
Sbjct: 88  KAHKKLT-RSALLLGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICY 145

Query: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253
           + FG++   +D       +   E ++  +  S+ + +  P++   P   +  L R     
Sbjct: 146 LTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRR----- 196

Query: 254 YDFLSRLIEKASVNRKPQLPQH----FVDAYLDEMD---QGKNDPSSTFSKENLI----- 301
              L + IEK     + QL QH        + D MD   QG   PS       L+     
Sbjct: 197 ---LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVH 253

Query: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS---WDDKCKM 358
            +  +L+I GTETT N L WA++F+  +P IQ ++Q+E+D  +GP    S   + D+ ++
Sbjct: 254 MAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARL 313

Query: 359 PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPE 418
           P   A + EVLR   +VPL + H T+  + + GY IP+GT +I NL   H DE  W  P 
Sbjct: 314 PLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPH 373

Query: 419 VFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV 478
            F P+RFL+      K    + F  G R CLGE LAR+E+F+  T LLQ F L    + +
Sbjct: 374 EFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 429

Query: 479 PDLK--PRLGMTLQPQPYLICAERR 501
           P L+  P   + L+ QP+ +  + R
Sbjct: 430 PSLQPLPHCSVILKMQPFQVRLQPR 454


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  127 bits (320), Expect = 2e-29
 Identities = 122/475 (25%), Positives = 204/475 (42%), Gaps = 31/475 (6%)

Query: 41  PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100
           PGP  LPF+GNI S      +  +   K+   YG+++    G    + +   D++K  LV
Sbjct: 39  PGPTPLPFLGNILSYHKGFCMFDMECHKK---YGKVWGFYDGQQPVLAITDPDMIKTVLV 95

Query: 101 HQS-EIFADR-PCLPL-FMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157
            +   +F +R P  P+ FMK       ++      W   R L   +F     G+      
Sbjct: 96  KECYSVFTNRRPFGPVGFMKSA-----ISIAEDEEWKRLRSLLSPTFTS---GKLKEMVP 147

Query: 158 ILEETKFFNDAI------ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211
           I+ +   + D +      E   G+P   K +      ++     FG      +      +
Sbjct: 148 IIAQ---YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 204

Query: 212 ELFSENVELAASASVFL-YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKP 270
           E   + +        FL    FP++  +P  +   +      V +FL + +++   +R  
Sbjct: 205 ENTKKLLRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262

Query: 271 QLPQHFVD---AYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327
              +H VD     +D  +  + +     S   L+      I AG ETT++VL + +  +A
Sbjct: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322

Query: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDA 387
            +P++Q ++Q+EID ++     P++D   +M Y + V++E LR   I  + +     +D 
Sbjct: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDV 381

Query: 388 VVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRH 447
            + G  IPKG  V+   Y++H D KYW +PE F PERF   +          PF  G R+
Sbjct: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

Query: 448 CLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQ-PYLICAERR 501
           C+G   A M M L    +LQ F      E    LK  LG  LQP+ P ++  E R
Sbjct: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  124 bits (312), Expect = 2e-28
 Identities = 120/474 (25%), Positives = 206/474 (43%), Gaps = 41/474 (8%)

Query: 41  PGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLV 100
           PGP  LP +GN+ S             K+   YG+++    G +  + +   DV++  LV
Sbjct: 39  PGPTPLPLLGNVLSYRQGLWKFDTECYKK---YGKMWGTYEGQLPVLAITDPDVIRTVLV 95

Query: 101 HQS-EIFADRPCL-PL-FMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157
            +   +F +R  L P+ FMK       ++      W   R L   +F     G+      
Sbjct: 96  KECYSVFTNRRSLGPVGFMKSA-----ISLAEDEEWKRIRSLLSPTFTS---GKLKEMFP 147

Query: 158 ILEETKFFNDAI------ETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMI 211
           I+ +   + D +      E  KG+P   K +      ++     FG      +      +
Sbjct: 148 IIAQ---YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFV 204

Query: 212 ELFSENVELAASASVFL-YNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLI---EKASVN 267
           E   + ++      +FL    FP++  +    +  LF    +  +FLS+ +   +K+ +N
Sbjct: 205 ESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI--NFLSKSVNRMKKSRLN 262

Query: 268 RKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMA 327
            K +    F+   +D  +  + +     S   L       I AG ETT++VL + +  +A
Sbjct: 263 DKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 322

Query: 328 LYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDA 387
            +P++Q ++QKEID ++     P++D   +M Y + V++E LR    V + +     +D 
Sbjct: 323 THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDV 381

Query: 388 VVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL-----VPFS 442
            + G  IPKG+ V+   Y++H D KYW +PE F PERF        KK+++      PF 
Sbjct: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF------SKKKDSIDPYIYTPFG 435

Query: 443 LGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLI 496
            G R+C+G   A M M L    +LQ F      E    LK      LQP+  ++
Sbjct: 436 TGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIV 489


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  119 bits (299), Expect = 5e-27
 Identities = 78/253 (30%), Positives = 123/253 (48%), Gaps = 5/253 (1%)

Query: 253 VYDFLSRLIEKASVNRKPQLPQHFVD---AYLDEMDQGKNDPSSTFSKENLIFSVGELII 309
           V  FL++ +++    R  +  +H VD     +D  +   ++     S   L+      I 
Sbjct: 245 VISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIF 304

Query: 310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 369
           AG ETT++VL + I  +A +P++Q +VQKEID ++     P++D   ++ Y + V++E L
Sbjct: 305 AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETL 364

Query: 370 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 429
           R    V + +     +D  + G  IPKG  V+   Y +H D KYW +PE F PERF   +
Sbjct: 365 RLFP-VAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKN 423

Query: 430 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL-GMT 488
                     PF  G R+C+G   A + M L    +LQ F      E    LK R  G+ 
Sbjct: 424 KDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLL 483

Query: 489 LQPQPYLICAERR 501
           L  +P ++ AE R
Sbjct: 484 LTEKPIVLKAESR 496


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  114 bits (285), Expect = 2e-25
 Identities = 112/485 (23%), Positives = 202/485 (41%), Gaps = 30/485 (6%)

Query: 4   LWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPH 63
           LW A    +  G +L L L         K ++    P      P +G+   +        
Sbjct: 15  LWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFF 74

Query: 64  VYMRKQSQVYGE--IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121
             + + ++ Y    +  L +G +  V L   + V+  L    +I  D+  +  F++    
Sbjct: 75  QQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQI--DKSSMYKFLEPWLG 132

Query: 122 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRP-FDFK 180
            GLL S  G  W   R++   +F +     + F   + E+       +E +  +  F+  
Sbjct: 133 LGLLTST-GNKWRSRRKMLTPTFHFTIL--EDFLDIMNEQANILVKKLEKHINQEAFNCF 189

Query: 181 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGI--- 237
             IT    +I      G+    +  D    +       E+     +F     PW+ +   
Sbjct: 190 FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEM-----IFRRIKMPWLWLDLW 244

Query: 238 -LPFGKHQQLFRNAAVVYDFLSRLI-EKASV----------NRKPQLPQHFVDAYLDEMD 285
            L F +  +  ++  +++ F + +I E+A+            R     ++   A+LD + 
Sbjct: 245 YLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304

Query: 286 QGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMG 345
              +D  +  S E++   V   +  G +TT   + W++  +   P +Q +V  E+D + G
Sbjct: 305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG 364

Query: 346 PNGKPSW-DDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNL 404
            + +P+  +D  K+ Y E V+ E LR    VPL    + SED  V GY + KGT  +   
Sbjct: 365 KSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIP 423

Query: 405 YSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTA 464
           Y++H D +Y+ +PE F PERF   +       A VPFS G R+C+G+  A ME     + 
Sbjct: 424 YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSC 483

Query: 465 LLQRF 469
           +L+ F
Sbjct: 484 ILRHF 488


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  112 bits (280), Expect = 8e-25
 Identities = 73/252 (28%), Positives = 120/252 (47%), Gaps = 13/252 (5%)

Query: 237 ILPFGKHQQLFRNA-AVVYDFLSRLIEKASVNRKPQLPQHFVDA----YLDEMDQGKNDP 291
           +  F    Q+F      ++ F  ++I+    + K +L Q         +LD +   K++ 
Sbjct: 236 VFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSEN 295

Query: 292 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 351
           +  FS+ +L   V   + AG +TT++ + W +  +A YP  Q + + EI  ++G     +
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 352 WDDKCKMPYTEAVLHEVLRF----CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407
           W+   +MPYT   + E LR      NI  L     T  D    G S+P G TV  N++++
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPD----GRSLPAGITVFINIWAL 411

Query: 408 HFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQ 467
           H +  +W DP+VF+P RF   +       A +PFS G R+C+G+H A +E  +     L 
Sbjct: 412 HHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLL 471

Query: 468 RFHLHFPHELVP 479
           RF L   H   P
Sbjct: 472 RFKLAPDHSRPP 483


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.141    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,533,668
Number of Sequences: 37866
Number of extensions: 890749
Number of successful extensions: 3477
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 3236
Number of HSP's gapped (non-prelim): 109
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.