Search of human proteins with 4507689

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507689 transient receptor potential cation channel,
subfamily M, member 2 [Homo sapiens]
         (1503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507689 transient receptor potential cation channel, subfamil...  3066   0.0  
gi|109689695 transient receptor potential cation channel, subfam...   838   0.0  
gi|11225266 transient receptor potential cation channel, subfami...   758   0.0  
gi|21314671 transient receptor potential cation channel, subfami...   721   0.0  
gi|154091314 transient receptor potential cation channel, subfam...   564   e-160
gi|154091318 transient receptor potential cation channel, subfam...   528   e-149
gi|154091320 transient receptor potential cation channel, subfam...   528   e-149
gi|154091316 transient receptor potential cation channel, subfam...   525   e-148
gi|154091312 transient receptor potential cation channel, subfam...   524   e-148
gi|154091310 transient receptor potential cation channel, subfam...   521   e-147
gi|154091308 transient receptor potential cation channel, subfam...   520   e-147
gi|148612863 transient receptor potential cation channel, subfam...   506   e-143
gi|18921093 transient receptor potential cation channel, subfami...   459   e-128
gi|94538366 transient receptor potential cation channel, subfami...   297   6e-80
gi|45935368 transient receptor potential cation channel, subfami...   192   3e-48
gi|55953096 transient receptor potential cation channel, subfami...   184   6e-46
gi|37594457 nudix-type motif 9 isoform b [Homo sapiens]               165   3e-40
gi|13129010 nudix-type motif 9 isoform a [Homo sapiens]               165   3e-40
gi|6912736 transient receptor potential cation channel, subfamil...    92   3e-18
gi|209863024 transient receptor potential cation channel, subfam...    92   5e-18
gi|7706747 transient receptor potential cation channel, subfamil...    89   3e-17
gi|194733735 transient receptor potential cation channel, subfam...    88   7e-17
gi|4507687 transient receptor potential cation channel, subfamil...    88   7e-17
gi|209863026 transient receptor potential cation channel, subfam...    87   1e-16
gi|209863030 transient receptor potential cation channel, subfam...    87   2e-16
gi|4507685 transient receptor potential cation channel, subfamil...    84   1e-15
gi|9966865 transient receptor potential cation channel, subfamil...    80   1e-14
gi|209863032 transient receptor potential cation channel, subfam...    79   4e-14
gi|5730102 transient receptor potential cation channel, subfamil...    74   1e-12
gi|209863028 transient receptor potential cation channel, subfam...    72   5e-12

>gi|4507689 transient receptor potential cation channel, subfamily M,
            member 2 [Homo sapiens]
          Length = 1503

 Score = 3066 bits (7950), Expect = 0.0
 Identities = 1503/1503 (100%), Positives = 1503/1503 (100%)

Query: 1    MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLS 60
            MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLS
Sbjct: 1    MEPSALRKAGSEQEEGFEGLPRRVTDLGMVSNLRRSNSSLFKSWRLQCPFGNNDKQESLS 60

Query: 61   SWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQ 120
            SWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQ
Sbjct: 61   SWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKKHVQ 120

Query: 121  EMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF 180
            EMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF
Sbjct: 121  EMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNF 180

Query: 181  NMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIG 240
            NMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIG
Sbjct: 181  NMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIG 240

Query: 241  VATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP 300
            VATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP
Sbjct: 241  VATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIP 300

Query: 301  LRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVA 360
            LRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVA
Sbjct: 301  LRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVA 360

Query: 361  DVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFR 420
            DVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFR
Sbjct: 361  DVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFR 420

Query: 421  EGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWK 480
            EGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWK
Sbjct: 421  EGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWK 480

Query: 481  PSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVL 540
            PSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVL
Sbjct: 481  PSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVL 540

Query: 541  VEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQ 600
            VEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQ
Sbjct: 541  VEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQ 600

Query: 601  GVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILK 660
            GVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILK
Sbjct: 601  GVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILK 660

Query: 661  ELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQL 720
            ELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQL
Sbjct: 661  ELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQL 720

Query: 721  ALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQD 780
            ALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQD
Sbjct: 721  ALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQD 780

Query: 781  VGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV 840
            VGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV
Sbjct: 781  VGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV 840

Query: 841  CEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILS 900
            CEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILS
Sbjct: 841  CEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILS 900

Query: 901  LDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNE 960
            LDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNE
Sbjct: 901  LDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNE 960

Query: 961  RRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAF 1020
            RRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAF
Sbjct: 961  RRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAF 1020

Query: 1021 PEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAA 1080
            PEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAA
Sbjct: 1021 PEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAA 1080

Query: 1081 PPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQ 1140
            PPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQ
Sbjct: 1081 PPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQ 1140

Query: 1141 KQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRA 1200
            KQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRA
Sbjct: 1141 KQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRA 1200

Query: 1201 SGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNE 1260
            SGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNE
Sbjct: 1201 SGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDSYHVNARHLLYPNCPVTRFPVPNE 1260

Query: 1261 KVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQ 1320
            KVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQ
Sbjct: 1261 KVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSFHGPYTVQ 1320

Query: 1321 AGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLP 1380
            AGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLP
Sbjct: 1321 AGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAICRKSIKKMLEVLVVKLP 1380

Query: 1381 LSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWI 1440
            LSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWI
Sbjct: 1381 LSEHWALPGGSREPGEMLPRKLKRILRQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWI 1440

Query: 1441 ETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFG 1500
            ETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFG
Sbjct: 1441 ETVAVSVHFQDQNDVELNRLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFG 1500

Query: 1501 AHY 1503
            AHY
Sbjct: 1501 AHY 1503


>gi|109689695 transient receptor potential cation channel, subfamily
            M, member 8 [Homo sapiens]
          Length = 1104

 Score =  838 bits (2166), Expect = 0.0
 Identities = 457/1084 (42%), Positives = 661/1084 (60%), Gaps = 63/1084 (5%)

Query: 56   QESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDP 115
            +  L ++I  N KK+ECV+F + SK ++    VC+CGY   QH+E        Q  +W+ 
Sbjct: 38   ESDLVNFIQANFKKRECVFFTKDSKATEN---VCKCGYAQSQHMEGT---QINQSEKWNY 91

Query: 116  KKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTG 175
            KKH +E PTDAFGDI F  L +K  KY+R+S DT + ++Y L+TQHW L  PNL+ISVTG
Sbjct: 92   KKHTKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTG 150

Query: 176  GAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGE 235
            GAKNF +KPR++ IF R L+ +AQ+ GAWI+TGG+H G+MK +GE VRD ++S S +E  
Sbjct: 151  GAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEEN- 208

Query: 236  LITIGVATWGTVHRREGLIH---PTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTH 292
            ++ IG+A WG V  R+ LI      G F A+Y++D+  +  L  LD+NH+H +LVD+G H
Sbjct: 209  IVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCH 268

Query: 293  GQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVV 352
            G   VE  LR +LEK+ISE+T +      KIPIVC    GG  TL  I+ +  N  PCVV
Sbjct: 269  GHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVV 328

Query: 353  VEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRR 412
            VEGSG++ADVIA +  +  + +T S +++KL  F         E     W K +++I+  
Sbjct: 329  VEGSGQIADVIASLVEVEDA-LTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILEC 387

Query: 413  RQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEI 472
              LLTV +  + G + V  AI  AL KA  + +    +NW+ QLKL + WN++D+A  EI
Sbjct: 388  SHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQ-DKDNWNGQLKLLLEWNQLDLANDEI 446

Query: 473  FMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLF 532
            F ++ +W+ +DL   M  ALI ++P+FV+LFLENG+ L++F+T D L  L+ N   S L 
Sbjct: 447  FTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSN-HFSTLV 505

Query: 533  HSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592
            +  LQ               A       +   + +L+ +F +      R+          
Sbjct: 506  YRNLQ--------------IAKNSYNDALLTFVWKLVANFRRGFRKEDRNGR-------- 543

Query: 593  PHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652
              + + +  VS              T  P++ L IWAI+QN++EL+ +IW Q++ C  AA
Sbjct: 544  DEMDIELHDVS------------PITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAA 591

Query: 653  LACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712
            L  SK+LK L+K + D +++ E   LA EYE RA+ +FTECY  DE+ A++LL    EAW
Sbjct: 592  LGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAW 651

Query: 713  GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLIS 772
            G + CL+LA+EA D  F++  G+Q FL+K W+G++S D   W++ LC+   PL+  G +S
Sbjct: 652  GGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVS 711

Query: 773  FREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAI 832
            FR+K +           AFFT+P VVF  N++ Y AFL LFAYVL++DF  VP   E  +
Sbjct: 712  FRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVL 771

Query: 833  YLWLFSLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL---IP 889
            Y  +F L C+E+RQ + +            YF+D WN +D   +  F+AG+  RL     
Sbjct: 772  YSLVFVLFCDEVRQWYVN---------GVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNK 822

Query: 890  ATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFG 949
            ++LY GRVI  LD+I+F LRL+HIFT+S+ LGPKII+++RM+ DVFFFLFL AVW+V+FG
Sbjct: 823  SSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFG 882

Query: 950  VAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCP 1009
            VA+Q IL  NE+R  W+FR  +Y  YL +FGQ+P  +DG  ++  HC+  G +  KP C 
Sbjct: 883  VARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNES-KPLCV 941

Query: 1010 ESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHD 1069
            E D     P FPEW+T+ L+C+Y+L TNILL+NLL+AMF YT   VQE+ DQ+WKFQR+ 
Sbjct: 942  ELD-EHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYF 1000

Query: 1070 LIEEYHGRPAAPPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLK 1129
            L++EY  R   P PFI+ ++  + +K+       +++ +      KNE+   L+WE  +K
Sbjct: 1001 LVQEYCSRLNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMK 1060

Query: 1130 ENYL 1133
            ENYL
Sbjct: 1061 ENYL 1064


>gi|11225266 transient receptor potential cation channel, subfamily M,
            member 5 [Homo sapiens]
          Length = 1165

 Score =  758 bits (1958), Expect = 0.0
 Identities = 458/1172 (39%), Positives = 653/1172 (55%), Gaps = 104/1172 (8%)

Query: 128  GDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLK 187
            G++ F G  +K  K+VRV      SV++ L+   W L  PNL++S+ G  + F MK  L+
Sbjct: 26   GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85

Query: 188  SIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTV 247
             + R+GLVK AQ+TGAWI+T     G+ + VG+AVRD SL+S+  +  ++ +G+A+ G V
Sbjct: 86   DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145

Query: 248  HRREGLIHPTGSFPAEYILDEDG-QGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLE 306
              R  L      FP  Y  D+ G QG L  LDSN SHFILV+ G  G+      LR RLE
Sbjct: 146  LHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLE 205

Query: 307  KFISEQTKERGGV-AIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEGSGRVADVIAQ 365
            K ISEQ    GG  +I+IP++C+++ G P TL  I  A     P +++ GSG +ADV+A 
Sbjct: 206  KHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAA 265

Query: 366  VANLPVSDITISLIQQKLSVFFQEMFET--FTESRIVEWTKKIQDIVRRRQLLTVFREGK 423
            + N P   + +  + +K    F+E F +  F+   IV WTK +Q+I   + LLTV+   +
Sbjct: 266  LVNQP--HLLVPKVAEKQ---FKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQ 320

Query: 424  DGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSD 483
            +G +++D  IL+AL+KA +S      +  D +LKLAVAW+RVDIA+SEIF  + +WK  D
Sbjct: 321  EGSEELDTVILKALVKACKSHSQEPQDYLD-ELKLAVAWDRVDIAKSEIFNGDVEWKSCD 379

Query: 484  LHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQK----- 538
            L   M  AL+SNKPEFV+LF++NG  + +F+T+  L  LY ++    L    LQ+     
Sbjct: 380  LEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEA 439

Query: 539  ------VLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592
                  +  +    P   P  P   +H V++VL++ L D  +  Y   R  DR R     
Sbjct: 440  RLTLAGLGTQQAREPPAGP--PAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRR--AEK 495

Query: 593  PHVKLNVQGVSLRSLYKRSSGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652
               K       L  L ++S        +P RDL +WA++QNR E+A   WA  Q+ +AAA
Sbjct: 496  GPAKRPTGQKWLLDLNQKSE-------NPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAA 548

Query: 653  LACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712
            LA  KILKE+S  E  T++         +YE  A+ +F+ECY   E RA  LL R +  W
Sbjct: 549  LAACKILKEMSHLE--TEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCW 606

Query: 713  GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLIS 772
             KTTCL LA EA    F +H G+QAFLT++WWG ++    + R+    L   L+ T LI+
Sbjct: 607  SKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLIT 666

Query: 773  FREKR--------LQD---------------------VGTPAA-------------RARA 790
            F E+         LQD                     V  P A             R R 
Sbjct: 667  FSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRK 726

Query: 791  FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPV---PSWCECAIYLWLFSLVCEEMRQL 847
            F+ APV VF  N++ YFAFL LF YVL+VDF+P    PS  E  +Y W+F+LV EE+RQ 
Sbjct: 727  FWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786

Query: 848  FYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPGRVILSLDFILFC 907
            F+  ++  L+KK  LY  D WNK D+ AI LF+ G+TCR++P+    GR +L++DF++F 
Sbjct: 787  FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFT 846

Query: 908  LRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLF 967
            LRL+HIF I K LGPKII+V+RMMKDVFFFLF L+VW+V++GV  QA+L  ++ R++W+F
Sbjct: 847  LRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIF 906

Query: 968  RGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPY----KPKCPESDATQQRPAFPEW 1023
            R  +Y  YL IFGQIP  +D ++    +CS   T P      P CP          +  W
Sbjct: 907  RRVLYRPYLQIFGQIP--LDEIDEARVNCS---THPLLLEDSPSCPS--------LYANW 953

Query: 1024 LTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPP 1083
            L +LLL  +LL TN+LL+NLLIAMF+YTFQ VQ + D  WKFQR++LI EYH RPA  PP
Sbjct: 954  LVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPP 1013

Query: 1084 FILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQR 1143
            FILLSHL L ++RV  K    + + L+  L    +  +++WE   KEN+L   + +++  
Sbjct: 1014 FILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDS 1073

Query: 1144 PEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGF 1203
              + +   +++VD +   L           E+R+  LE Q+   +  +  +   L   G 
Sbjct: 1074 EGEVLRKTAHRVDFIAKYLG-----GLREQEKRIKCLESQINYCSVLVSSVADVLAQGGG 1128

Query: 1204 SSEADVPTLASQKAAEEPDAEPGGRKKTEEPG 1235
               +      SQ  A +     GG    E+PG
Sbjct: 1129 PRSSQHCGEGSQLVAAD---HRGGLDGWEQPG 1157


>gi|21314671 transient receptor potential cation channel, subfamily M,
            member 4 [Homo sapiens]
          Length = 1214

 Score =  721 bits (1862), Expect = 0.0
 Identities = 440/1221 (36%), Positives = 653/1221 (53%), Gaps = 105/1221 (8%)

Query: 57   ESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQH----LEEATKPHTFQGTQ 112
            E   SWIP+  KKK C  F+  S  +D G  +CQCG     H    +E+A        T 
Sbjct: 5    EKEQSWIPKIFKKKTCTTFIVDS--TDPGGTLCQCGRPRTAHPAVAMEDAFGAAVV--TV 60

Query: 113  WDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLIS 172
            WD   H  E PTDA+G++ FTG  +K   ++R+S  T  + +Y L+T+ WG   PNL++S
Sbjct: 61   WDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVS 120

Query: 173  VTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYK 232
            V GG+    ++  L+ + RRGLV+ AQ+TGAWI+TGG HTG+ + VG AVRD  ++S+  
Sbjct: 121  VLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMAST-G 179

Query: 233  EGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC-LDSNHSHFILVDDGT 291
              +++ +GVA WG V  R+ LI+P GSFPA Y    D +  +   LD N+S F LVDDGT
Sbjct: 180  GTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGT 239

Query: 292  HGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCV 351
            HG  G E   R RLE +IS+Q    GG  I IP++ ++++G    L  I+NAT    PC+
Sbjct: 240  HGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCL 299

Query: 352  VVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVR 411
            +V GSG  AD +A+     ++  +    Q +       +   F +  +     +++ I+ 
Sbjct: 300  LVAGSGGAADCLAETLEDTLAPGSGGARQGEAR---DRIRRFFPKGDLEVLQAQVERIMT 356

Query: 412  RRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
            R++LLTV+   +DG ++ +  +L+AL+KA  S +   + +   +L+LAVAWNRVDIA+SE
Sbjct: 357  RKELLTVY-SSEDGSEEFETIVLKALVKACGSSEASAYLD---ELRLAVAWNRVDIAQSE 412

Query: 472  IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
            +F  + QW+   L  ++  AL++++PEFV+L + +G+ L  F+T   L  LY     + L
Sbjct: 413  LFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSL 472

Query: 532  FHSKL-QKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL 590
              + L Q       + PA    A  L+   V  VLR LLG    P YP     D      
Sbjct: 473  IRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWD------ 526

Query: 591  PVPHVKLNVQGVSLRSLYKRSSGHVTFT----MDPIRDLLIWAIVQNRRELAGIIWAQSQ 646
              PH      G S+  L  +++  ++        P  DLL+WA++ NR ++A   W    
Sbjct: 527  --PHPGQGF-GESMYLLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGS 583

Query: 647  DCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLT 706
            + +++AL    +L+ +++ E D + +     LA ++E   + +F ECYR  E RA +LL 
Sbjct: 584  NAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLL 643

Query: 707  RVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLL 766
            R    WG  TCLQLA++A    F +  G+Q+ LT+ WWG ++    +W + L     PL+
Sbjct: 644  RRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLI 703

Query: 767  LTGLISFREKRLQ-----------------------------DVGTPAARARA------- 790
             T LI+FR+   +                              +G P    R        
Sbjct: 704  YTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRC 763

Query: 791  -----------FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPV-PSWCECAIYLWLFS 838
                       F+ APV +F  N++SY  FL LF+ VL+VDFQP  P   E  +Y W F+
Sbjct: 764  GGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFT 823

Query: 839  LVCEEMRQLFY-----------DPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL 887
            L+CEE+RQ               P    L ++  LY +D WN+ D+ A+  F+ G+ CRL
Sbjct: 824  LLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL 883

Query: 888  IPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVS 947
             P   + GR +L +DF++F +RL+HIFT++K LGPKI+IV +MMKDVFFFLF L VW+V+
Sbjct: 884  TPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVA 943

Query: 948  FGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPK 1007
            +GVA + +L   +     + R   Y  YL IFGQIP     V    EH + +    +   
Sbjct: 944  YGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVAL-MEHSNCSSEPGFWAH 1002

Query: 1008 CPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQR 1067
             P + A      +  WL VLLL ++LL  NILL+NLLIAMF+YTF +VQ ++D  WK QR
Sbjct: 1003 PPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQR 1062

Query: 1068 HDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLK-------TPAKRHKQLKNKLEKNEEAA 1120
            + LI E+H RPA  PPFI++SHL+L ++++  +       +PA  H   +  L K  E  
Sbjct: 1063 YRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH--FRVYLSKEAERK 1120

Query: 1121 LLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASL 1180
            LL+WE   KEN+L  R   +++   ++++  S KVD     L L  L      EQRL  L
Sbjct: 1121 LLTWESVHKENFLLARARDKRESDSERLKRTSQKVD-----LALKQLGHIREYEQRLKVL 1175

Query: 1181 EEQVAQTARALHWIVRTLRAS 1201
            E +V Q +R L W+   L  S
Sbjct: 1176 EREVQQCSRVLGWVAEALSRS 1196


>gi|154091314 transient receptor potential cation channel, subfamily
            M, member 3 isoform k [Homo sapiens]
          Length = 1707

 Score =  564 bits (1453), Expect = e-160
 Identities = 405/1255 (32%), Positives = 634/1255 (50%), Gaps = 156/1255 (12%)

Query: 61   SWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHL--------------EEATKPH 106
            SWI     K+ECV+ + S+K  D  +  C CG    QH+              E     +
Sbjct: 63   SWIERAFYKRECVHIIPSTK--DPHR--CCCGRLIGQHVGLTPSISVLQNEKNESRLSRN 118

Query: 107  TFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKK-YVRVSQDTPSSVIYHLMTQHWGLD 165
              Q  +W   KH Q  PTDAFG I F G     K  YVRVS DT   ++ HLMT+ W L+
Sbjct: 119  DIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLE 178

Query: 166  VPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDF 225
            +P LLISV GG +NF ++P+LK +F +GL+K A TTGAWI TGG +TGV++ VG+A++D 
Sbjct: 179  LPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDH 238

Query: 226  SLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFI 285
            +  S    G++ TIG+A WG V  +E LI      P  Y    +    LT L+S HSHFI
Sbjct: 239  ASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP--YQTMSNPMSKLTVLNSMHSHFI 293

Query: 286  LVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDN--A 343
            L D+GT G+YG E+ LR +LEK IS Q K    +   +P+V +++EGGP  +  +     
Sbjct: 294  LADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQGVPVVALIVEGGPNVISIVLEYLR 352

Query: 344  TTNGTPCVVVEGSGRVADVIAQVANLPVSDITIS-LIQQKLSVFFQEMFETFTESRIVEW 402
             T   P VV +GSGR +D++A           I+  ++ +L V  Q+ F T+T ++    
Sbjct: 353  DTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTF-TYTRTQAQHL 411

Query: 403  TKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAW 462
               + + +++++L+TVFR G +G QD+D+AIL ALLK + +           QL LA+AW
Sbjct: 412  FIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA-------PDQLSLALAW 464

Query: 463  NRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYL 522
            NRVDIARS+IF+   QW    L   M  AL+ ++ +FVKL +ENGV +  F+T   L  L
Sbjct: 465  NRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEEL 524

Query: 523  YENLD--PSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRP 580
            Y       + L+H      LV D ++    P   R+ +  +  V+  L+G   +  Y R 
Sbjct: 525  YNTRHGPSNTLYH------LVRDVKKGNLPPDY-RISLIDIGLVIEYLMGGAYRCNYTRK 577

Query: 581  RHNDRLRLLLPVPHVK-LNVQGVSL-------RSLYKRSSGHVTFTMD---------PIR 623
            R       L      K L + G+         R   K+    V   +D         P  
Sbjct: 578  RFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFH 637

Query: 624  DLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDS----SEEMLALA 679
            +L++WA++  R+++A   W   ++ +A AL   K+ K ++ E  + D     S+E+   +
Sbjct: 638  ELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNS 697

Query: 680  EEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFL 739
             ++   A+ +  + Y++DE+ A KLLT   + W   TCLQLA+ AK   F++H   Q  L
Sbjct: 698  RDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLL 757

Query: 740  TKVWWGQLSV--DNGLWRVTLCMLAFPLL------------------------------- 766
            T +W G+L +  ++GL +V L +L  P +                               
Sbjct: 758  TDMWMGRLRMRKNSGL-KVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPE 816

Query: 767  ------------LTGLI------SFREKRLQDVGTP------AARARAFFTAPVVVFHLN 802
                        LT ++      S R+K  ++V +         +   F+ AP+V F   
Sbjct: 817  KPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFY 876

Query: 803  ILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQ-LFYDPDECGLMKKAA 861
             L+Y  +L LF Y+++V  +  PS  E  +  ++F+L  E+MR+ L  +P +  L++K  
Sbjct: 877  TLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGK--LLQKVK 934

Query: 862  LYFSDFWNKLDVGAILLFVAGLTCRLIPATLYP-GRVILSLDFILFCLRLMHIFTISKTL 920
            ++  ++WN  D+ AILLF  G+  RL        GRVI  ++ I + +RL+ IF ++K L
Sbjct: 935  VWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYL 994

Query: 921  GPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFG 980
            GP ++++ +MM D+ +F+ ++ V ++SFGVA+QAIL  NE     L +   Y  Y  I+G
Sbjct: 995  GPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYG 1054

Query: 981  QIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPE--WLTVLLLCLYLLFTNI 1038
            ++  + D ++     C  N T        E     Q P      W+   ++  YLL  NI
Sbjct: 1055 EV--FADQID---PPCGQNETR-------EDGKIIQLPPCKTGAWIVPAIMACYLLVANI 1102

Query: 1039 LLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHLQLFIKRVV 1098
            LL+NLLIA+FN TF +V+  ++Q+WKFQR+ LI  +H RP  PPP I+ SH+ +  + + 
Sbjct: 1103 LLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLC 1162

Query: 1099 LK------TPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDIS 1152
             +       P +R   LK  +  +E   +  +E    E Y + +  +     +++I   S
Sbjct: 1163 CRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTS 1222

Query: 1153 NKVDAMVDLLDLDPLKRSGSMEQ-------RLASLEEQVAQTARALHWIVRTLRA 1200
             +V+ M   L+ +  +R  SM+        RLA LE+ + + A AL  +    RA
Sbjct: 1223 ERVENMSMRLE-EVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERA 1276


>gi|154091318 transient receptor potential cation channel, subfamily
            M, member 3 isoform d [Homo sapiens]
          Length = 1544

 Score =  528 bits (1361), Expect = e-149
 Identities = 371/1151 (32%), Positives = 593/1151 (51%), Gaps = 131/1151 (11%)

Query: 142  YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
            YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202  GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
            GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262  AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAI 321
              Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q K    +  
Sbjct: 119  --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQ 175

Query: 322  KIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEGSGRVADVIAQVANLPVSDITIS-L 378
             +P+V +++EGGP  +  +      T   P VV +GSGR +D++A           I+  
Sbjct: 176  GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINES 235

Query: 379  IQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALL 438
            ++ +L V  Q+ F T+T ++       + + +++++L+TVFR G +G QD+D+AIL ALL
Sbjct: 236  LRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALL 294

Query: 439  KASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPE 498
            K + +           QL LA+AWNRVDIARS+IF+   QW    L   M  AL+ ++ +
Sbjct: 295  KGANASA-------PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVD 347

Query: 499  FVKLFLENGVQLKEFVTWDTLLYLYENLD--PSCLFHSKLQKVLVEDPERPACAPAAPRL 556
            FVKL +ENGV +  F+T   L  LY       + L+H      LV D ++    P   R+
Sbjct: 348  FVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYH------LVRDVKKGNLPPDY-RI 400

Query: 557  QMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVT 616
             +  +  V+  L+G   +  Y R R       L       + ++    R   K+    V 
Sbjct: 401  SLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRG--RKTTKKREEEVD 458

Query: 617  FTMD---------PIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEE 667
              +D         P  +L++WA++  R+++A   W   ++ +A AL   K+ K ++ E  
Sbjct: 459  IDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEAS 518

Query: 668  DTDS----SEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALE 723
            + D     S+E+   + ++   A+ +  + Y++DE+ A KLLT   + W   TCLQLA+ 
Sbjct: 519  ENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVA 578

Query: 724  AKDMKFVSHGGIQAFLTKVWWGQLSV--DNGLWRVTLCMLAFPLL--------------- 766
            AK   F++H   Q  LT +W G+L +  ++GL +V L +L  P +               
Sbjct: 579  AKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL-KVILGILLPPSILSLEFKNKDDMPYMS 637

Query: 767  ----------------------------LTGLI------SFREKRLQDVGTP------AA 786
                                        LT ++      S R+K  ++V +         
Sbjct: 638  QAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGR 697

Query: 787  RARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQ 846
            +   F+ AP+V F    L+Y  +L LF Y+++V  +  PS  E  +  ++F+L  E+MR+
Sbjct: 698  KIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMRE 757

Query: 847  -LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYP-GRVILSLDFI 904
             L  +P +  L++K  ++  ++WN  D+ AILLF  G+  RL        GRVI  ++ I
Sbjct: 758  ILMSEPGK--LLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNII 815

Query: 905  LFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVD 964
             + +RL+ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFGVA+QAIL  NE    
Sbjct: 816  YWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSW 875

Query: 965  WLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPE-- 1022
             L +   Y  Y  I+G++  + D ++     C  N T        E     Q P      
Sbjct: 876  KLAKNIFYMPYWMIYGEV--FADQID---PPCGQNETR-------EDGKIIQLPPCKTGA 923

Query: 1023 WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPP 1082
            W+   ++  YLL  NILL+NLLIA+FN TF +V+  ++Q+WKFQR+ LI  +H RP  PP
Sbjct: 924  WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPP 983

Query: 1083 PFILLSHLQLFIKRVVLK------TPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNR 1136
            P I+ SH+ +  + +  +       P +R   LK  +  +E   +  +E    E Y + +
Sbjct: 984  PLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREK 1043

Query: 1137 QFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQ-------RLASLEEQVAQTAR 1189
              +     +++I   S +V+ M   L+ +  +R  SM+        RLA LE+ + + A 
Sbjct: 1044 DDRFNSSNDERIRVTSERVENMSMRLE-EVNEREHSMKASLQTVDIRLAQLEDLIGRMAT 1102

Query: 1190 ALHWIVRTLRA 1200
            AL  +    RA
Sbjct: 1103 ALERLTGLERA 1113


>gi|154091320 transient receptor potential cation channel, subfamily
            M, member 3 isoform a [Homo sapiens]
          Length = 1554

 Score =  528 bits (1360), Expect = e-149
 Identities = 374/1159 (32%), Positives = 595/1159 (51%), Gaps = 137/1159 (11%)

Query: 142  YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
            YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202  GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
            GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262  AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAI 321
              Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q K    +  
Sbjct: 119  --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQ 175

Query: 322  KIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEGSGRVADVIAQVANLPVSDITIS-L 378
             +P+V +++EGGP  +  +      T   P VV +GSGR +D++A           I+  
Sbjct: 176  GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINES 235

Query: 379  IQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALL 438
            ++ +L V  Q+ F T+T ++       + + +++++L+TVFR G +G QD+D+AIL ALL
Sbjct: 236  LRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALL 294

Query: 439  KASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPE 498
            K + +           QL LA+AWNRVDIARS+IF+   QW    L   M  AL+ ++ +
Sbjct: 295  KGANASA-------PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVD 347

Query: 499  FVKLFLENGVQLKEFVTWDTLLYLYENLD--PSCLFHSKLQKVLVEDPERPACAPAAPRL 556
            FVKL +ENGV +  F+T   L  LY       + L+H      LV D ++    P   R+
Sbjct: 348  FVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYH------LVRDVKKGNLPPDY-RI 400

Query: 557  QMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVK-LNVQGVSL-------RSLY 608
             +  +  V+  L+G   +  Y R R       L      K L + G+         R   
Sbjct: 401  SLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTT 460

Query: 609  KRSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKIL 659
            K+    V   +D         P  +L++WA++  R+++A   W   ++ +A AL   K+ 
Sbjct: 461  KKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLC 520

Query: 660  KELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKT 715
            K ++ E  + D     S+E+   + ++   A+ +  + Y++DE+ A KLLT   + W   
Sbjct: 521  KAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNA 580

Query: 716  TCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV--DNGLWRVTLCMLAFPLL------- 766
            TCLQLA+ AK   F++H   Q  LT +W G+L +  ++GL +V L +L  P +       
Sbjct: 581  TCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL-KVILGILLPPSILSLEFKN 639

Query: 767  ------------------------------------LTGLI------SFREKRLQDVGTP 784
                                                LT ++      S R+K  ++V + 
Sbjct: 640  KDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSK 699

Query: 785  ------AARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFS 838
                    +   F+ AP+V F    L+Y  +L LF Y+++V  +  PS  E  +  ++F+
Sbjct: 700  HRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFT 759

Query: 839  LVCEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYP-GR 896
            L  E+MR+ L  +P +  L++K  ++  ++WN  D+ AILLF  G+  RL        GR
Sbjct: 760  LGIEKMREILMSEPGK--LLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR 817

Query: 897  VILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAIL 956
            VI  ++ I + +RL+ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFGVA+QAIL
Sbjct: 818  VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAIL 877

Query: 957  IHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQ 1016
              NE     L +   Y  Y  I+G++  + D ++     C  N T        E     Q
Sbjct: 878  FPNEEPSWKLAKNIFYMPYWMIYGEV--FADQID---PPCGQNETR-------EDGKIIQ 925

Query: 1017 RPAFPE--WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEY 1074
             P      W+   ++  YLL  NILL+NLLIA+FN TF +V+  ++Q+WKFQR+ LI  +
Sbjct: 926  LPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF 985

Query: 1075 HGRPAAPPPFILLSHLQLFIKRVVLK------TPAKRHKQLKNKLEKNEEAALLSWEIYL 1128
            H RP  PPP I+ SH+ +  + +  +       P +R   LK  +  +E   +  +E   
Sbjct: 986  HERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQC 1045

Query: 1129 KENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQ-------RLASLE 1181
             E Y + +  +     +++I   S +V+ M   L+ +  +R  SM+        RLA LE
Sbjct: 1046 IEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE-EVNEREHSMKASLQTVDIRLAQLE 1104

Query: 1182 EQVAQTARALHWIVRTLRA 1200
            + + + A AL  +    RA
Sbjct: 1105 DLIGRMATALERLTGLERA 1123


>gi|154091316 transient receptor potential cation channel, subfamily
            M, member 3 isoform e [Homo sapiens]
          Length = 1556

 Score =  525 bits (1351), Expect = e-148
 Identities = 371/1158 (32%), Positives = 593/1158 (51%), Gaps = 133/1158 (11%)

Query: 142  YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
            YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202  GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
            GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262  AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAI 321
              Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q K    +  
Sbjct: 119  --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQ 175

Query: 322  KIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEGSGRVADVIAQVANLPVSDITIS-L 378
             +P+V +++EGGP  +  +      T   P VV +GSGR +D++A           I+  
Sbjct: 176  GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINES 235

Query: 379  IQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALL 438
            ++ +L V  Q+ F T+T ++       + + +++++L+TVFR G +G QD+D+AIL ALL
Sbjct: 236  LRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALL 294

Query: 439  KASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPE 498
            K + +           QL LA+AWNRVDIARS+IF+   QW    L   M  AL+ ++ +
Sbjct: 295  KGANASA-------PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVD 347

Query: 499  FVKLFLENGVQLKEFVTWDTLLYLYENLD-PSCLFHSKLQKVLVEDPERPACA------- 550
            FVKL +ENGV +  F+T   L  LY     PS   +  ++ V  +  E P          
Sbjct: 348  FVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV--KKREYPGFGWIYFKGN 405

Query: 551  -PAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVKLNVQGVSLRSLYK 609
             P   R+ +  +  V+  L+G   +  Y R R       L       + ++    R   K
Sbjct: 406  LPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRG--RKTTK 463

Query: 610  RSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACSKILK 660
            +    V   +D         P  +L++WA++  R+++A   W   ++ +A AL   K+ K
Sbjct: 464  KREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCK 523

Query: 661  ELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAWGKTT 716
             ++ E  + D     S+E+   + ++   A+ +  + Y++DE+ A KLLT   + W   T
Sbjct: 524  AMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNAT 583

Query: 717  CLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV--DNGLWRVTLCMLAFPLL-------- 766
            CLQLA+ AK   F++H   Q  LT +W G+L +  ++GL +V L +L  P +        
Sbjct: 584  CLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL-KVILGILLPPSILSLEFKNK 642

Query: 767  -----------------------------------LTGLI------SFREKRLQDVGTP- 784
                                               LT ++      S R+K  ++V +  
Sbjct: 643  DDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKH 702

Query: 785  -----AARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSL 839
                   +   F+ AP+V F    L+Y  +L LF Y+++V  +  PS  E  +  ++F+L
Sbjct: 703  RLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTL 762

Query: 840  VCEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYP-GRV 897
              E+MR+ L  +P +  L++K  ++  ++WN  D+ AILLF  G+  RL        GRV
Sbjct: 763  GIEKMREILMSEPGK--LLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRV 820

Query: 898  ILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI 957
            I  ++ I + +RL+ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFGVA+QAIL 
Sbjct: 821  IYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILF 880

Query: 958  HNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQR 1017
             NE     L +   Y  Y  I+G++  + D ++     C  N T        E     Q 
Sbjct: 881  PNEEPSWKLAKNIFYMPYWMIYGEV--FADQID---PPCGQNETR-------EDGKIIQL 928

Query: 1018 PAFPE--WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYH 1075
            P      W+   ++  YLL  NILL+NLLIA+FN TF +V+  ++Q+WKFQR+ LI  +H
Sbjct: 929  PPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFH 988

Query: 1076 GRPAAPPPFILLSHLQLFIKRVVLK------TPAKRHKQLKNKLEKNEEAALLSWEIYLK 1129
             RP  PPP I+ SH+ +  + +  +       P +R   LK  +  +E   +  +E    
Sbjct: 989  ERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCI 1048

Query: 1130 ENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQ-------RLASLEE 1182
            E Y + +  +     +++I   S +V+ M   L+ +  +R  SM+        RLA LE+
Sbjct: 1049 EEYFREKDDRFNSSNDERIRVTSERVENMSMRLE-EVNEREHSMKASLQTVDIRLAQLED 1107

Query: 1183 QVAQTARALHWIVRTLRA 1200
             + + A AL  +    RA
Sbjct: 1108 LIGRMATALERLTGLERA 1125


>gi|154091312 transient receptor potential cation channel, subfamily
            M, member 3 isoform b [Homo sapiens]
          Length = 1566

 Score =  524 bits (1350), Expect = e-148
 Identities = 374/1166 (32%), Positives = 595/1166 (51%), Gaps = 139/1166 (11%)

Query: 142  YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
            YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202  GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
            GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262  AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAI 321
              Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q K    +  
Sbjct: 119  --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQ 175

Query: 322  KIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEGSGRVADVIAQVANLPVSDITIS-L 378
             +P+V +++EGGP  +  +      T   P VV +GSGR +D++A           I+  
Sbjct: 176  GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINES 235

Query: 379  IQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALL 438
            ++ +L V  Q+ F T+T ++       + + +++++L+TVFR G +G QD+D+AIL ALL
Sbjct: 236  LRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALL 294

Query: 439  KASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPE 498
            K + +           QL LA+AWNRVDIARS+IF+   QW    L   M  AL+ ++ +
Sbjct: 295  KGANASA-------PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVD 347

Query: 499  FVKLFLENGVQLKEFVTWDTLLYLYENLD-PSCLFHSKLQKVLVEDPERPACA------- 550
            FVKL +ENGV +  F+T   L  LY     PS   +  ++ V  +  E P          
Sbjct: 348  FVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDV--KKREYPGFGWIYFKGN 405

Query: 551  -PAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVK-LNVQGVSL---- 604
             P   R+ +  +  V+  L+G   +  Y R R       L      K L + G+      
Sbjct: 406  LPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPL 465

Query: 605  ---RSLYKRSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWAQSQDCIAAA 652
               R   K+    V   +D         P  +L++WA++  R+++A   W   ++ +A A
Sbjct: 466  RRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKA 525

Query: 653  LACSKILKELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRV 708
            L   K+ K ++ E  + D     S+E+   + ++   A+ +  + Y++DE+ A KLLT  
Sbjct: 526  LVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYE 585

Query: 709  SEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV--DNGLWRVTLCMLAFPLL 766
             + W   TCLQLA+ AK   F++H   Q  LT +W G+L +  ++GL +V L +L  P +
Sbjct: 586  LKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL-KVILGILLPPSI 644

Query: 767  -------------------------------------------LTGLI------SFREKR 777
                                                       LT ++      S R+K 
Sbjct: 645  LSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKD 704

Query: 778  LQDVGTP------AARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECA 831
             ++V +         +   F+ AP+V F    L+Y  +L LF Y+++V  +  PS  E  
Sbjct: 705  EEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWI 764

Query: 832  IYLWLFSLVCEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPA 890
            +  ++F+L  E+MR+ L  +P +  L++K  ++  ++WN  D+ AILLF  G+  RL   
Sbjct: 765  VISYIFTLGIEKMREILMSEPGK--LLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQ 822

Query: 891  TLYP-GRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFG 949
                 GRVI  ++ I + +RL+ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFG
Sbjct: 823  PFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFG 882

Query: 950  VAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCP 1009
            VA+QAIL  NE     L +   Y  Y  I+G++  + D ++     C  N T        
Sbjct: 883  VARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV--FADQID---PPCGQNETR------- 930

Query: 1010 ESDATQQRPAFPE--WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQR 1067
            E     Q P      W+   ++  YLL  NILL+NLLIA+FN TF +V+  ++Q+WKFQR
Sbjct: 931  EDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQR 990

Query: 1068 HDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLK------TPAKRHKQLKNKLEKNEEAAL 1121
            + LI  +H RP  PPP I+ SH+ +  + +  +       P +R   LK  +  +E   +
Sbjct: 991  YQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKV 1050

Query: 1122 LSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQ------ 1175
              +E    E Y + +  +     +++I   S +V+ M   L+ +  +R  SM+       
Sbjct: 1051 HDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE-EVNEREHSMKASLQTVD 1109

Query: 1176 -RLASLEEQVAQTARALHWIVRTLRA 1200
             RLA LE+ + + A AL  +    RA
Sbjct: 1110 IRLAQLEDLIGRMATALERLTGLERA 1135


>gi|154091310 transient receptor potential cation channel, subfamily
            M, member 3 isoform g [Homo sapiens]
          Length = 1569

 Score =  521 bits (1341), Expect = e-147
 Identities = 371/1175 (31%), Positives = 594/1175 (50%), Gaps = 154/1175 (13%)

Query: 142  YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
            YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202  GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
            GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262  AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQT-------- 313
              Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q         
Sbjct: 119  --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPF 176

Query: 314  ----------------KERGGVAIKIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEG 355
                             +  G+   +P+V +++EGGP  +  +      T   P VV +G
Sbjct: 177  FSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDG 236

Query: 356  SGRVADVIAQVANLPVSDITIS-LIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQ 414
            SGR +D++A           I+  ++ +L V  Q+ F T+T ++       + + +++++
Sbjct: 237  SGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKE 295

Query: 415  LLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFM 474
            L+TVFR G +G QD+D+AIL ALLK + +           QL LA+AWNRVDIARS+IF+
Sbjct: 296  LITVFRMGSEGHQDIDLAILTALLKGANASA-------PDQLSLALAWNRVDIARSQIFI 348

Query: 475  DEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLD--PSCLF 532
               QW    L   M  AL+ ++ +FVKL +ENGV +  F+T   L  LY       + L+
Sbjct: 349  YGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLY 408

Query: 533  HSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592
            H      LV D ++    P   R+ +  +  V+  L+G   +  Y R R       L   
Sbjct: 409  H------LVRDVKKGNLPPDY-RISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 461

Query: 593  PHVKLNVQGVSLRSLYKRSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWA 643
                + ++    R   K+    V   +D         P  +L++WA++  R+++A   W 
Sbjct: 462  KRDDIPLRRG--RKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQ 519

Query: 644  QSQDCIAAALACSKILKELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEE 699
              ++ +A AL   K+ K ++ E  + D     S+E+   + ++   A+ +  + Y++DE+
Sbjct: 520  HGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQ 579

Query: 700  RAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV--DNGLWRVT 757
             A KLLT   + W   TCLQLA+ AK   F++H   Q  LT +W G+L +  ++GL +V 
Sbjct: 580  LAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGL-KVI 638

Query: 758  LCMLAFPLL-------------------------------------------LTGLI--- 771
            L +L  P +                                           LT ++   
Sbjct: 639  LGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRN 698

Query: 772  ---SFREKRLQDVGTP------AARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQ 822
               S R+K  ++V +         +   F+ AP+V F    L+Y  +L LF Y+++V  +
Sbjct: 699  NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 758

Query: 823  PVPSWCECAIYLWLFSLVCEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVA 881
              PS  E  +  ++F+L  E+MR+ L  +P +  L++K  ++  ++WN  D+ AILLF  
Sbjct: 759  RWPSTQEWIVISYIFTLGIEKMREILMSEPGK--LLQKVKVWLQEYWNVTDLIAILLFSV 816

Query: 882  GLTCRLIPATLYP-GRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFL 940
            G+  RL        GRVI  ++ I + +RL+ IF ++K LGP ++++ +MM D+ +F+ +
Sbjct: 817  GMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVII 876

Query: 941  LAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNG 1000
            + V ++SFGVA+QAIL  NE     L +   Y  Y  I+G++  + D ++     C  N 
Sbjct: 877  MLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV--FADQID---PPCGQNE 931

Query: 1001 TDPYKPKCPESDATQQRPAFPE--WLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEH 1058
            T        E     Q P      W+   ++  YLL  NILL+NLLIA+FN TF +V+  
Sbjct: 932  TR-------EDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 984

Query: 1059 TDQIWKFQRHDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLK------TPAKRHKQLKNK 1112
            ++Q+WKFQR+ LI  +H RP  PPP I+ SH+ +  + +  +       P +R   LK  
Sbjct: 985  SNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLF 1044

Query: 1113 LEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGS 1172
            +  +E   +  +E    E Y + +  +     +++I   S +V+ M   L+ +  +R  S
Sbjct: 1045 ITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE-EVNEREHS 1103

Query: 1173 MEQ-------RLASLEEQVAQTARALHWIVRTLRA 1200
            M+        RLA LE+ + + A AL  +    RA
Sbjct: 1104 MKASLQTVDIRLAQLEDLIGRMATALERLTGLERA 1138


>gi|154091308 transient receptor potential cation channel, subfamily
            M, member 3 isoform f [Homo sapiens]
          Length = 1579

 Score =  520 bits (1340), Expect = e-147
 Identities = 374/1183 (31%), Positives = 596/1183 (50%), Gaps = 160/1183 (13%)

Query: 142  YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
            YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2    YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202  GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
            GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62   GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262  AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQT-------- 313
              Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q         
Sbjct: 119  --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPF 176

Query: 314  ----------------KERGGVAIKIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEG 355
                             +  G+   +P+V +++EGGP  +  +      T   P VV +G
Sbjct: 177  FSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDG 236

Query: 356  SGRVADVIAQVANLPVSDITIS-LIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQ 414
            SGR +D++A           I+  ++ +L V  Q+ F T+T ++       + + +++++
Sbjct: 237  SGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTF-TYTRTQAQHLFIILMECMKKKE 295

Query: 415  LLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFM 474
            L+TVFR G +G QD+D+AIL ALLK + +           QL LA+AWNRVDIARS+IF+
Sbjct: 296  LITVFRMGSEGHQDIDLAILTALLKGANASA-------PDQLSLALAWNRVDIARSQIFI 348

Query: 475  DEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLD--PSCLF 532
               QW    L   M  AL+ ++ +FVKL +ENGV +  F+T   L  LY       + L+
Sbjct: 349  YGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLY 408

Query: 533  HSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPV 592
            H      LV D ++    P   R+ +  +  V+  L+G   +  Y R R       L   
Sbjct: 409  H------LVRDVKKGNLPPDY-RISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 461

Query: 593  PHVK-LNVQGVSL-------RSLYKRSSGHVTFTMD---------PIRDLLIWAIVQNRR 635
               K L + G+         R   K+    V   +D         P  +L++WA++  R+
Sbjct: 462  KRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQ 521

Query: 636  ELAGIIWAQSQDCIAAALACSKILKELSKEEEDTDS----SEEMLALAEEYEHRAIGVFT 691
            ++A   W   ++ +A AL   K+ K ++ E  + D     S+E+   + ++   A+ +  
Sbjct: 522  KMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 581

Query: 692  ECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV-- 749
            + Y++DE+ A KLLT   + W   TCLQLA+ AK   F++H   Q  LT +W G+L +  
Sbjct: 582  QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRK 641

Query: 750  DNGLWRVTLCMLAFPLL------------------------------------------- 766
            ++GL +V L +L  P +                                           
Sbjct: 642  NSGL-KVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDME 700

Query: 767  LTGLI------SFREKRLQDVGTP------AARARAFFTAPVVVFHLNILSYFAFLCLFA 814
            LT ++      S R+K  ++V +         +   F+ AP+V F    L+Y  +L LF 
Sbjct: 701  LTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFN 760

Query: 815  YVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDV 873
            Y+++V  +  PS  E  +  ++F+L  E+MR+ L  +P +  L++K  ++  ++WN  D+
Sbjct: 761  YIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGK--LLQKVKVWLQEYWNVTDL 818

Query: 874  GAILLFVAGLTCRLIPATLYP-GRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMK 932
             AILLF  G+  RL        GRVI  ++ I + +RL+ IF ++K LGP ++++ +MM 
Sbjct: 819  IAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMI 878

Query: 933  DVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFN 992
            D+ +F+ ++ V ++SFGVA+QAIL  NE     L +   Y  Y  I+G++  + D ++  
Sbjct: 879  DMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV--FADQID-- 934

Query: 993  PEHCSPNGTDPYKPKCPESDATQQRPAFPE--WLTVLLLCLYLLFTNILLLNLLIAMFNY 1050
               C  N T        E     Q P      W+   ++  YLL  NILL+NLLIA+FN 
Sbjct: 935  -PPCGQNETR-------EDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNN 986

Query: 1051 TFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLK------TPAK 1104
            TF +V+  ++Q+WKFQR+ LI  +H RP  PPP I+ SH+ +  + +  +       P +
Sbjct: 987  TFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDE 1046

Query: 1105 RHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDL 1164
            R   LK  +  +E   +  +E    E Y + +  +     +++I   S +V+ M   L+ 
Sbjct: 1047 RDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE- 1105

Query: 1165 DPLKRSGSMEQ-------RLASLEEQVAQTARALHWIVRTLRA 1200
            +  +R  SM+        RLA LE+ + + A AL  +    RA
Sbjct: 1106 EVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERA 1148


>gi|148612863 transient receptor potential cation channel, subfamily
            M, member 7 [Homo sapiens]
          Length = 1865

 Score =  506 bits (1302), Expect = e-143
 Identities = 389/1325 (29%), Positives = 626/1325 (47%), Gaps = 233/1325 (17%)

Query: 58   SLSSWIPENIKKKECVYFVESSKLSDA---GKVVCQ------CGYTHEQHL--------- 99
            S  SWI   + K+ECVY + SSK       G  +CQ      CG   +QH          
Sbjct: 2    SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMK 61

Query: 100  --EEATKPHTFQGTQ-WDPKKHVQEMPTDAFGDIVFTGLSQKVK-KYVRVSQDTPSSVIY 155
              +     H  Q  + W  +KH ++ PTDA+G I F G S   + KYVR+S DT   VI 
Sbjct: 62   YSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121

Query: 156  HLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVM 215
             L+ + W +++P L+ISV GG + F + PR+K +  +GL+K A TTGAWI+TGG +TGV 
Sbjct: 122  QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181

Query: 216  KQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLT 275
            K VG+A+++ +  SS K   + TIG+A WG +  R  L+      P + +L+      L 
Sbjct: 182  KHVGDALKEHASRSSRK---ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNP--LSKLN 236

Query: 276  CLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPG 335
             L++ HSHFILVDDGT G+YG E+ LR  LEK I++Q +    +   +P+V ++ EGGP 
Sbjct: 237  VLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQ-RIHARIGQGVPVVALIFEGGPN 295

Query: 336  TLHTIDNATTNG--TPCVVVEGSGRVADVIAQV-------ANLPVS---DITISLIQQKL 383
             + T+          P VV EG+GR AD++A +        NLP +   DI IS I++  
Sbjct: 296  VILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDI-ISTIKKTF 354

Query: 384  SVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRS 443
            +         F ++  +   + + + ++R++L+TVF  G D  QD+DVAIL ALLK + +
Sbjct: 355  N---------FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNA 405

Query: 444  QDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLF 503
                       QL L +AW+RVDIA++ +F+   QW    L   M  AL+ ++  FVKL 
Sbjct: 406  SAF-------DQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLL 458

Query: 504  LENGVQLKEFVTWDTLLYLYENLDPSC---LFHSKLQKVLVEDPERPACAPAAPRLQMHH 560
            +ENGV + +F+T   L  LY          LFH      LV D ++    P   ++ +  
Sbjct: 459  IENGVSMHKFLTIPRLEELYNTKQGPTNPMLFH------LVRDVKQGNLPPGY-KITLID 511

Query: 561  VAQVLRELLGDFTQPLYPRPR--------------------------------------- 581
            +  V+  L+G   +  Y R R                                       
Sbjct: 512  IGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADK 571

Query: 582  -----HNDRLRLLLPVPHVKLNVQGVSLRSLYKRSSGHVTFTMDP--------IRDLLIW 628
                 HN  ++   P    +  +  V      KR+   +    DP        + +LLIW
Sbjct: 572  KEKMRHNHFIKTAQPY---RPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIW 628

Query: 629  AIVQNRRELAGIIWAQSQDCIAAALACSKILKELSKEEEDTD----SSEEMLALAEEYEH 684
            A +  R+ +A  +W   ++ +A AL   KI + ++ E + +D    +SEE+   + ++  
Sbjct: 629  ACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQ 688

Query: 685  RAIGVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWW 744
             A+ +  + +R+DE  A KLLT   + W  +TCL+LA+ ++   FV+H   Q  L+ +W 
Sbjct: 689  LAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWM 748

Query: 745  GQLSVDNGLW-RVTLCMLAFPLLLT----------------------------------- 768
            G+L++    W +V L +L  P +L                                    
Sbjct: 749  GRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITE 808

Query: 769  --GLISFREKRLQDVGT--------------PAARA-RAFFTAPVVVFHLNILSYFAFLC 811
               +  F+E R+ D                 P  R   AF+ AP+V F  N L+Y  FL 
Sbjct: 809  EIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLM 868

Query: 812  LFAYVLMVDFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLM-KKAALYFSDFWNK 870
            L+ +V++V  + +PS  E  +  ++F+   E++R++F    E G + +K  ++FSD++N 
Sbjct: 869  LYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMS--EAGKVNQKIKVWFSDYFNI 926

Query: 871  LDVGAILLFVAGLTCRLIP----ATLYP------GRVILSLDFILFCLRLMHIFTISKTL 920
             D  AI+ F  G   R       A  Y       GR+I  L+ I + +RL+    +++  
Sbjct: 927  SDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQA 986

Query: 921  GPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFG 980
            GP ++++ +M+ ++F+ + ++A+ ++SFGV ++AIL  +E     L +  V+H Y  IFG
Sbjct: 987  GPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFG 1046

Query: 981  QIPGYIDGVNFN----PEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFT 1036
            ++  Y   V  N    P+ C P GT                     WLT  L  +YL   
Sbjct: 1047 EVYAYEIDVCANDSVIPQICGP-GT---------------------WLTPFLQAVYLFVQ 1084

Query: 1037 NILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLSHL-QLFIK 1095
             I+++NLLIA FN  + QV+  ++ +WK+QR+  I  YH +P  PPP I+LSH+  LF  
Sbjct: 1085 YIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCC 1144

Query: 1096 RVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKV 1155
                +   K     K  L + ++  L  +E    E Y   +  +     E++I     +V
Sbjct: 1145 ICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERV 1204

Query: 1156 DAM-VDLLDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGFSSEADVPTLAS 1214
            + M + + ++    R   +++ L SL+ Q+          V TL+           TL +
Sbjct: 1205 EQMCIQIKEVG--DRVNYIKRSLQSLDSQIGHLQDLSALTVDTLK-----------TLTA 1251

Query: 1215 QKAAE 1219
            QKA+E
Sbjct: 1252 QKASE 1256


>gi|18921093 transient receptor potential cation channel, subfamily M,
            member 6 [Homo sapiens]
          Length = 2022

 Score =  459 bits (1180), Expect = e-128
 Identities = 361/1269 (28%), Positives = 585/1269 (46%), Gaps = 176/1269 (13%)

Query: 54   DKQESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQ---------CGYTHEQHLE---- 100
            ++ +S  SWI     K+EC   + SSK       VCQ         CG     H      
Sbjct: 8    ERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYS 67

Query: 101  ---EATKPHTFQGTQWDPKKHVQEMPTDAFGDIVFT-GLSQKVKKYVRVSQDTPSSVIYH 156
                A K    +  QW  +KH  + PTD FG I F  G      KY+R S DT    + H
Sbjct: 68   WTISAAKGK--ESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLH 125

Query: 157  LMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMK 216
            LM + W +++P L+ISV GG +NF M  + K IF +GLVK A+TTGAWIIT G +TGV K
Sbjct: 126  LMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSK 185

Query: 217  QVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC 276
             VG+A++     SS+   ++ T+G+  WG +  +  LI         Y   ++    LT 
Sbjct: 186  HVGDALKS---HSSHSLRKIWTVGIPPWGVIENQRDLIGK--DVVCLYQTLDNPLSKLTT 240

Query: 277  LDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQ---TKERGGVAIKIPIVCVVLEGG 333
            L+S HSHFIL DDGT G+YG E+ LR  LEK++S Q    + R GV    P+V +V+EGG
Sbjct: 241  LNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGV----PVVGLVVEGG 296

Query: 334  PGTLHTIDNATTNGTPCVVVEGSGRVADVIAQV-ANLPVSDITISLIQQKLSVFFQEMFE 392
            P  + ++     +  P VV EG+GR AD++A    +L    +    +++++    Q  F 
Sbjct: 297  PNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTF- 355

Query: 393  TFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENW 452
             F+  +     + + + +  R  +T+F    + QQD+D+AIL ALLK +       + + 
Sbjct: 356  NFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGT-------NLSA 408

Query: 453  DHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKE 512
              QL LA+AW+RVDIA+  I + E  WKP  L   M+ AL+ ++ +FVKL +E GV L  
Sbjct: 409  SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468

Query: 513  FVTWDTLLYLYENLD--PSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLG 570
            F+T   L  LY       + L H  +Q V      +     +  R+ +  +  V+  L+G
Sbjct: 469  FLTIPRLEELYNTKQGPTNTLLHHLVQDV------KQHTLLSGYRITLIDIGLVVEYLIG 522

Query: 571  -----DFTQP-----------LYPRPRHNDRLR-----------LLLPVPHVKLNVQGVS 603
                 ++T+             Y   RH+   R            +      K   + + 
Sbjct: 523  RAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIV 582

Query: 604  LRSLYKRS-------SGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACS 656
            L    K+S           T  + P  DLL+WA++  R+++A   W   ++    A+   
Sbjct: 583  LHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIAC 642

Query: 657  KILKELSKEEEDT----DSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712
             + + ++ E +++    D+SEE+   ++++   A+ +  + ++++E  A  LLT     W
Sbjct: 643  ILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNW 702

Query: 713  GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLW-RVTLCMLAFPLLLTGLI 771
              +TCL+LA+      FVSH   Q  LT +W G+L +    W ++ + ++  P +LT  +
Sbjct: 703  SNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILT--L 760

Query: 772  SFREK----------------------------------------------RLQDVGTPA 785
             F+ K                                                Q  G  +
Sbjct: 761  EFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLES 820

Query: 786  ARARAFFTAPVVVFHLNILSYFAF--------LCLFAYVLMVDFQPVPSWCECAIYLWLF 837
                  +T  V  F+   +  F F        L LF Y ++V+ QP PS  E  + +++F
Sbjct: 821  GHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIF 880

Query: 838  SLVCEEMRQL-FYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL-IPATLYPG 895
            +   E +R++   +P +    +K  ++ S++WN  +  AI LF AG   R   P     G
Sbjct: 881  TNAIEVVREICISEPGK--FTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAG 938

Query: 896  RVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAI 955
            R+I  +D I +  RL+  F +++  GP + ++ +M  ++F+ + ++A+ ++SFGVA++AI
Sbjct: 939  RLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAI 998

Query: 956  LIHNERRVDWLFRGAVYHSYLTIFGQI-PGYIDGVNFNPEHCSPNGTDPYKPKCPESDAT 1014
            L   E     L R  V+  Y  I+G++  G ID        CS       +P CP     
Sbjct: 999  LSPKEPPSWSLARDIVFEPYWMIYGEVYAGEID-------VCSS------QPSCPPG--- 1042

Query: 1015 QQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEY 1074
                    +LT  L  +YL    I+++NLLIA FN  +  ++  ++ +WK+ R+  I  Y
Sbjct: 1043 -------SFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTY 1095

Query: 1075 HGRPAAPPPFILLSHLQLFIKRVVLKTPAKRHKQ----LKNKLEKNEEAALLSWEIYLKE 1130
            H +P  PPP ILLSH+ L ++R+         ++    LK  L K +   L  +E    E
Sbjct: 1096 HEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVE 1155

Query: 1131 NYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARA 1190
             Y   +        E++I   S +V  M   L  +  ++   ++  L SL+ QV      
Sbjct: 1156 KYFHEKMEDVNCSCEERIRVTSERVTEMYFQLK-EMNEKVSFIKDSLLSLDSQVGHLQDL 1214

Query: 1191 LHWIVRTLR 1199
                V TL+
Sbjct: 1215 SALTVDTLK 1223


>gi|94538366 transient receptor potential cation channel, subfamily M,
            member 1 [Homo sapiens]
          Length = 1603

 Score =  297 bits (760), Expect = 6e-80
 Identities = 237/853 (27%), Positives = 408/853 (47%), Gaps = 100/853 (11%)

Query: 484  LHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYEN-LDPSCLFHSKLQKVLVE 542
            L   M  AL+ ++ +FVKL +ENGV ++ F+T   L  LY   L P    H     +LV 
Sbjct: 461  LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLH-----LLVR 515

Query: 543  DPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLLPVPHVK-LNVQG 601
            D ++    P    + +  +  VL  L+G   +  Y R         L      K L + G
Sbjct: 516  DVKKSNLPPDY-HISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLG 574

Query: 602  VS--------LRSLYKRSSGHVTFTMD---------PIRDLLIWAIVQNRRELAGIIWAQ 644
            +          +   K+    +   +D         P  +L++WA++  R+++A  +W +
Sbjct: 575  MEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQR 634

Query: 645  SQDCIAAALACSKILKELSKEEEDTDS----SEEMLALAEEYEHRAIGVFTECYRKDEER 700
             ++ +A AL   K+ K ++ E  ++D     S+++   ++++   A+ +  + Y+ DE+ 
Sbjct: 635  GEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQI 694

Query: 701  AQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV-DNGLWRVTLC 759
            A KLLT   + W  +TCL+LA+ AK   F++H   Q  LT +W G+L +  N   +V + 
Sbjct: 695  AMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMG 754

Query: 760  MLAFPLLLTGLISFR-------------------EKRLQDVGTPAARARA---------- 790
            +L  P +L   + FR                   E+   D    A   +           
Sbjct: 755  ILLPPTIL--FLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQR 812

Query: 791  ----------FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLFSLV 840
                      F+ AP+V F    +SY  +L LF YV++V     PS  E  +  ++ SL 
Sbjct: 813  SIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLA 872

Query: 841  CEEMRQ-LFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLI--PATLYPGRV 897
             E++R+ L  +P +  L +K  ++  ++WN  D+ AI  F+ G   RL   P   Y GRV
Sbjct: 873  LEKIREILMSEPGK--LSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGY-GRV 929

Query: 898  ILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILI 957
            I  +D I + +R++ IF ++K LGP ++++ +MM D+ +F+ ++ V ++SFGVA+QAIL 
Sbjct: 930  IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAIL- 988

Query: 958  HNERRVDW-LFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQ 1016
            H E +  W L R   Y  Y  I+G++  + D ++      +P    P      + +  + 
Sbjct: 989  HPEEKPSWKLARNIFYMPYWMIYGEV--FADQIDLYAMEINP----PCGENLYDEEGKRL 1042

Query: 1017 RPAFP-EWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYH 1075
             P  P  WLT  L+  YLL  NILL+NLLIA+FN TF +V+  ++Q+WKFQR+ LI  +H
Sbjct: 1043 PPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFH 1102

Query: 1076 GRPAAPPPFILLSHLQLFIKRVVLKTPAKRH-------KQLKNKLEKNEEAALLSWEIYL 1128
             RP  PPP I+LSH+ + I R+  +   KR        + LK  L   E   L  +E   
Sbjct: 1103 DRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQC 1162

Query: 1129 KENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTA 1188
             + + + ++ +Q+   +++I   S +V+ M   L+ +  +R   M+  L +++ ++AQ  
Sbjct: 1163 VQEHFREKEDEQQSSSDERIRVTSERVENMSMRLE-EINERETFMKTSLQTVDLRLAQLE 1221

Query: 1189 RALHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDS-----YHVNAR 1243
               + +V  L        +D+   A  +A+ E +A    R+ +    D      YH N  
Sbjct: 1222 ELSNRMVNALENLAGIDRSDL-IQARSRASSECEATYLLRQSSINSADGYSLYRYHFNGE 1280

Query: 1244 HLLYPNCPVTRFP 1256
             LL+ +  ++  P
Sbjct: 1281 ELLFEDTSLSTSP 1293



 Score =  258 bits (659), Expect = 3e-68
 Identities = 156/408 (38%), Positives = 230/408 (56%), Gaps = 29/408 (7%)

Query: 89  CQCGYTHEQHL-----------EEATKPHTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQ 137
           C CG    QH+           EE +K    Q  +W   KH Q  PTD++G + F G   
Sbjct: 7   CCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGGY 66

Query: 138 KVKK-YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVK 196
             K  Y+RVS DT    + HLM + W L++P LLISV GG +NF M+P+LK +F +GL+K
Sbjct: 67  SNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIK 126

Query: 197 VAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHP 256
            A TTGAWI TGG  TGV+  VG+A++D    SS   G +  IG+A WG V  +E L+  
Sbjct: 127 AAMTTGAWIFTGGVSTGVISHVGDALKD---HSSKSRGRVCAIGIAPWGIVENKEDLVGK 183

Query: 257 TGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKER 316
                  Y    +    L+ L+++H+HFIL D+GT G+YG E+ LR  LEK IS Q K  
Sbjct: 184 --DVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQ-KIN 240

Query: 317 GGVAIKIPIVCVVLEGGPGTLHTIDNATTN--GTPCVVVEGSGRVADVIAQVAN-LPVSD 373
             +   +P+V +V+EGGP  +  +          P V+ +GSGR +D+++          
Sbjct: 241 TRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGG 300

Query: 374 ITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAI 433
           I    ++++L V  Q+ F  + +++  +    I + +++++L+TVFR G +GQQD+++AI
Sbjct: 301 IINESLREQLLVTIQKTF-NYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAI 359

Query: 434 LQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFMDEWQWKP 481
           L ALLK +       + +   QL LA+AWNRVDIARS+IF+    W P
Sbjct: 360 LTALLKGT-------NVSAPDQLSLALAWNRVDIARSQIFVFGPHWPP 400


>gi|45935368 transient receptor potential cation channel, subfamily
           M, member 3 isoform h [Homo sapiens]
          Length = 230

 Score =  192 bits (487), Expect = 3e-48
 Identities = 103/225 (45%), Positives = 144/225 (64%), Gaps = 8/225 (3%)

Query: 142 YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
           YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2   YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202 GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
           GAWI TGG +TGV++ VG+A++D    +S   G++ TIG+A WG V  +E LI      P
Sbjct: 62  GAWIFTGGVNTGVIRHVGDALKD---HASKSRGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262 AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQTKERGGVAI 321
             Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q K    +  
Sbjct: 119 --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQ-KINTRIGQ 175

Query: 322 KIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEGSGRVADVIA 364
            +P+V +++EGGP  +  +      T   P VV +GSGR +D++A
Sbjct: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILA 220


>gi|55953096 transient receptor potential cation channel, subfamily
           M, member 3 isoform c [Homo sapiens]
          Length = 255

 Score =  184 bits (467), Expect = 6e-46
 Identities = 103/249 (41%), Positives = 145/249 (58%), Gaps = 31/249 (12%)

Query: 142 YVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTT 201
           YVRVS DT   ++ HLMT+ W L++P LLISV GG +NF ++P+LK +F +GL+K A TT
Sbjct: 2   YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61

Query: 202 GAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFP 261
           GAWI TGG +TGV++ VG+A++D +  S    G++ TIG+A WG V  +E LI      P
Sbjct: 62  GAWIFTGGVNTGVIRHVGDALKDHASKS---RGKICTIGIAPWGIVENQEDLIGRDVVRP 118

Query: 262 AEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQT-------- 313
             Y    +    LT L+S HSHFIL D+GT G+YG E+ LR +LEK IS Q         
Sbjct: 119 --YQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPF 176

Query: 314 ----------------KERGGVAIKIPIVCVVLEGGPGTLHTIDN--ATTNGTPCVVVEG 355
                            +  G+   +P+V +++EGGP  +  +      T   P VV +G
Sbjct: 177 FSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDG 236

Query: 356 SGRVADVIA 364
           SGR +D++A
Sbjct: 237 SGRASDILA 245


>gi|37594457 nudix-type motif 9 isoform b [Homo sapiens]
          Length = 300

 Score =  165 bits (418), Expect = 3e-40
 Identities = 102/285 (35%), Positives = 146/285 (51%), Gaps = 21/285 (7%)

Query: 1236 DSYHVNARHLLYPNCPVTRFPVPNEKVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEP 1295
            ++ H  AR   YP   V R  VPNEKV W  E+  Y P  YTA    A          E 
Sbjct: 9    ENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISES 68

Query: 1296 LSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRW 1355
              + ++N  DG  +R+S +G Y ++ G P NP GRTGL GRG L  +GPNH   P++TRW
Sbjct: 69   NFSPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRW 128

Query: 1356 RRNEDGAICRKSI--KKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPS 1413
            +R+  G      +  K +L+ + +K      WA+PGG  +PGE +   LKR   +E   S
Sbjct: 129  KRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNS 188

Query: 1414 F-----------ENLLKC----GMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELN 1458
                        E L K      + +YKGY+DDPRNTDNAW+ET AV+ H +    ++  
Sbjct: 189  LQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMD-- 246

Query: 1459 RLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY 1503
              N  L A D    ++W  ++ ++ LYA+H   ++  A +  AH+
Sbjct: 247  --NLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHW 289


>gi|13129010 nudix-type motif 9 isoform a [Homo sapiens]
          Length = 350

 Score =  165 bits (418), Expect = 3e-40
 Identities = 102/285 (35%), Positives = 146/285 (51%), Gaps = 21/285 (7%)

Query: 1236 DSYHVNARHLLYPNCPVTRFPVPNEKVPWETEFLIYDPPFYTAERKDAAAMDPMGDTLEP 1295
            ++ H  AR   YP   V R  VPNEKV W  E+  Y P  YTA    A          E 
Sbjct: 59   ENSHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISES 118

Query: 1296 LSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRW 1355
              + ++N  DG  +R+S +G Y ++ G P NP GRTGL GRG L  +GPNH   P++TRW
Sbjct: 119  NFSPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRW 178

Query: 1356 RRNEDGAICRKSI--KKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPS 1413
            +R+  G      +  K +L+ + +K      WA+PGG  +PGE +   LKR   +E   S
Sbjct: 179  KRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNS 238

Query: 1414 F-----------ENLLKC----GMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELN 1458
                        E L K      + +YKGY+DDPRNTDNAW+ET AV+ H +    ++  
Sbjct: 239  LQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMD-- 296

Query: 1459 RLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY 1503
              N  L A D    ++W  ++ ++ LYA+H   ++  A +  AH+
Sbjct: 297  --NLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHW 339


>gi|6912736 transient receptor potential cation channel, subfamily C,
            member 5 [Homo sapiens]
          Length = 973

 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 114/515 (22%), Positives = 200/515 (38%), Gaps = 111/515 (21%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I   S+D I  A      LKELSK E +  +  E L+          L +    R + +
Sbjct: 208  LIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEI 267

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWW-GQLS 748
                +R D            + +     L++A++    +FV+    Q  L  +W+ G   
Sbjct: 268  ILN-HRDDHSEELD-----PQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPG 321

Query: 749  VDNGLWRVTL--CM---LAFPLL-LTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLN 802
                 W V L  CM     FP+L +  LIS           P +    F   P + F  +
Sbjct: 322  WRRKHWVVKLLTCMTIGFLFPMLSIAYLIS-----------PRSNLGLFIKKPFIKFICH 370

Query: 803  ILSYFAFLCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECG 855
              SY  FL +      +++  D     P P+  E  I  W+   +  E+++++    + G
Sbjct: 371  TASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMW----DGG 426

Query: 856  LMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVIL 899
              +    Y  D+WN +D     L++A ++ +++    Y G                  + 
Sbjct: 427  FTE----YIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALF 482

Query: 900  SLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHN 959
            ++  IL  LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + 
Sbjct: 483  AISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYY 542

Query: 960  ERRV-------------------DWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNG 1000
            E R                      LF   +   + ++FG +  Y+  V           
Sbjct: 543  ETRAIDEPNNCKGIRCEKQNNAFSTLFE-TLQSLFWSVFGLLNLYVTNV----------- 590

Query: 1001 TDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTD 1060
                          + R  F E++   +   Y + + ++LLN+LIAM N ++Q + +H D
Sbjct: 591  --------------KARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHAD 636

Query: 1061 QIWKFQRHDLIEEYHGRPAA-PPPFILLSHLQLFI 1094
              WKF R  L   Y       PPPF ++   + F+
Sbjct: 637  IEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFL 671


>gi|209863024 transient receptor potential cation channel, subfamily
            C, member 4 isoform epsilon [Homo sapiens]
          Length = 982

 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 131/647 (20%), Positives = 242/647 (37%), Gaps = 111/647 (17%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I   S+D    A   S  L+ELSK E +  S  E L+          L +    R + +
Sbjct: 208  LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
                YR D    ++      ++      L+LA++ +  +FV+    Q  L   W+ +   
Sbjct: 268  ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319

Query: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
              G  R    +      + GL+ F    +  +  P +    F   P + F  +  SY  F
Sbjct: 320  --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376

Query: 810  LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
            L L      ++   D     P P+  E  I  W+   +  E++Q++    + GL      
Sbjct: 377  LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428

Query: 863  YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906
            Y  D+WN +D     L++A ++ +++    Y                    + ++  I  
Sbjct: 429  YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488

Query: 907  CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966
             LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + E      
Sbjct: 489  SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548

Query: 967  FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011
             +G                +   + +IFG I  Y+  V    E                 
Sbjct: 549  CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591

Query: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071
                    F E++   +   Y + + ++LLN+LIAM N ++Q + +H D  WKF R  L 
Sbjct: 592  --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLW 643

Query: 1072 EEYHGRPAA-PPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKE 1130
              Y       P PF ++   +     +         K+++ K E      + +      +
Sbjct: 644  MSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAAD 703

Query: 1131 NYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARA 1190
            N  ++ Q+Q+  R         N V   V  +  D     G  E+    L++ ++     
Sbjct: 704  NLRRHHQYQEVMR---------NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFE 754

Query: 1191 LHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDS 1237
            +  ++R  + S         T+ S  A++E        +K++  G+S
Sbjct: 755  VLGLLRGSKLS---------TIQSANASKESSNSADSDEKSDSEGNS 792


>gi|7706747 transient receptor potential cation channel, subfamily C,
            member 4 isoform alpha [Homo sapiens]
          Length = 977

 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 135/650 (20%), Positives = 241/650 (37%), Gaps = 122/650 (18%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I   S+D    A   S  L+ELSK E +  S  E L+          L +    R + +
Sbjct: 208  LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
                YR D    ++      ++      L+LA++ +  +FV+    Q  L   W+ +   
Sbjct: 268  ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319

Query: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
              G  R    +      + GL+ F    +  +  P +    F   P + F  +  SY  F
Sbjct: 320  --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376

Query: 810  LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
            L L      ++   D     P P+  E  I  W+   +  E++Q++    + GL      
Sbjct: 377  LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428

Query: 863  YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906
            Y  D+WN +D     L++A ++ +++    Y                    + ++  I  
Sbjct: 429  YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488

Query: 907  CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966
             LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + E      
Sbjct: 489  SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548

Query: 967  FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011
             +G                +   + +IFG I  Y+  V    E                 
Sbjct: 549  CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591

Query: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071
                    F E++   +   Y + + ++LLN+LIAM N ++Q + +H D  WKF R  L 
Sbjct: 592  --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLW 643

Query: 1072 EEYHGRPAA-PPPFILL---SHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIY 1127
              Y       P PF ++     L   IK +        H   K    K E    +     
Sbjct: 644  MSYFEEGGTLPTPFNVIPSPKSLWYLIKWI------WTHLCKKKMRRKPESFGTIGRR-- 695

Query: 1128 LKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQT 1187
              +N  ++ Q+Q+  R         N V   V  +  D     G  E+    L++ ++  
Sbjct: 696  AADNLRRHHQYQEVMR---------NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSF 746

Query: 1188 ARALHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDS 1237
               +  ++R  + S         T+ S  A++E        +K++  G+S
Sbjct: 747  RFEVLGLLRGSKLS---------TIQSANASKESSNSADSDEKSDSEGNS 787


>gi|194733735 transient receptor potential cation channel, subfamily
            C, member 3 isoform a [Homo sapiens]
          Length = 921

 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 117/554 (21%), Positives = 217/554 (39%), Gaps = 129/554 (23%)

Query: 645  SQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKL 704
            S+D +  AL  S  L +L+  E++  +    L++  + +   +GV   C  +D E  + +
Sbjct: 304  SEDPVLTALELSNELAKLANIEKEFKNDYRKLSM--QCKDFVVGVLDLC--RDSEEVEAI 359

Query: 705  LT---------RVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWR 755
            L           V       + ++LA++ +  KFV+H   Q  L  +W+  LS   GL  
Sbjct: 360  LNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLS---GLRE 416

Query: 756  VTLCMLAFPLLLTGL-ISFREKRLQDVG---TPAARARAFFTAPVVVFHLNILSYFAFLC 811
             T+ +    +L+  L + F       +G    P +R      +P + F  +  S+  FL 
Sbjct: 417  QTIAIKCLVVLVVALGLPFLA-----IGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLG 471

Query: 812  LFAYVLMVDFQPVPS----------------------WCECAIYLWLFSLVCEEMRQLFY 849
            L  +     F+ + +                      W E  I +W+  ++  E ++L+ 
Sbjct: 472  LLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWL 531

Query: 850  D-PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCR---------------------- 886
            + P E         Y    WN LD G + +F+A  T R                      
Sbjct: 532  EGPRE---------YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESD 582

Query: 887  LIPATLYP--------------------GRVILSLDFILFCLRLMHIFTISKTLGPKIII 926
            L   TL P                       + ++  +L   R+ +I   +++ GP  I 
Sbjct: 583  LSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 642

Query: 927  VKRMMKDVFFFLFLLAVWVVSFGVAKQAIL-IHNERRVDWLFRGAVYHSYLTIFGQIPGY 985
            + R +KD+F F+ L  +   +F +    +   +   +V+  F   V  S+ T+F  I G 
Sbjct: 643  LGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT-TVEESFKTLFWSIFGL 701

Query: 986  --IDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNL 1043
              +  V    +H                        F E +  +L  +Y +   ++LLN+
Sbjct: 702  SEVTSVVLKYDH-----------------------KFIENIGYVLYGIYNVTMVVVLLNM 738

Query: 1044 LIAMFNYTFQQVQEHTDQIWKFQRHDL-IEEYHGRPAAPPPFILLSHLQLFIKRV--VLK 1100
            LIAM N ++Q++++ +D  WKF R  L +  +      PPPF L+   + F+  +  ++ 
Sbjct: 739  LIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVN 798

Query: 1101 TPAKRHKQLKNKLE 1114
             P  R ++L+  +E
Sbjct: 799  FPKCRRRRLQKDIE 812


>gi|4507687 transient receptor potential cation channel, subfamily C,
            member 3 isoform b [Homo sapiens]
          Length = 848

 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 117/554 (21%), Positives = 217/554 (39%), Gaps = 129/554 (23%)

Query: 645  SQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKL 704
            S+D +  AL  S  L +L+  E++  +    L++  + +   +GV   C  +D E  + +
Sbjct: 231  SEDPVLTALELSNELAKLANIEKEFKNDYRKLSM--QCKDFVVGVLDLC--RDSEEVEAI 286

Query: 705  LT---------RVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWR 755
            L           V       + ++LA++ +  KFV+H   Q  L  +W+  LS   GL  
Sbjct: 287  LNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLS---GLRE 343

Query: 756  VTLCMLAFPLLLTGL-ISFREKRLQDVG---TPAARARAFFTAPVVVFHLNILSYFAFLC 811
             T+ +    +L+  L + F       +G    P +R      +P + F  +  S+  FL 
Sbjct: 344  QTIAIKCLVVLVVALGLPFLA-----IGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLG 398

Query: 812  LFAYVLMVDFQPVPS----------------------WCECAIYLWLFSLVCEEMRQLFY 849
            L  +     F+ + +                      W E  I +W+  ++  E ++L+ 
Sbjct: 399  LLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWL 458

Query: 850  D-PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCR---------------------- 886
            + P E         Y    WN LD G + +F+A  T R                      
Sbjct: 459  EGPRE---------YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESD 509

Query: 887  LIPATLYP--------------------GRVILSLDFILFCLRLMHIFTISKTLGPKIII 926
            L   TL P                       + ++  +L   R+ +I   +++ GP  I 
Sbjct: 510  LSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 569

Query: 927  VKRMMKDVFFFLFLLAVWVVSFGVAKQAIL-IHNERRVDWLFRGAVYHSYLTIFGQIPGY 985
            + R +KD+F F+ L  +   +F +    +   +   +V+  F   V  S+ T+F  I G 
Sbjct: 570  LGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFT-TVEESFKTLFWSIFGL 628

Query: 986  --IDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNL 1043
              +  V    +H                        F E +  +L  +Y +   ++LLN+
Sbjct: 629  SEVTSVVLKYDH-----------------------KFIENIGYVLYGIYNVTMVVVLLNM 665

Query: 1044 LIAMFNYTFQQVQEHTDQIWKFQRHDL-IEEYHGRPAAPPPFILLSHLQLFIKRV--VLK 1100
            LIAM N ++Q++++ +D  WKF R  L +  +      PPPF L+   + F+  +  ++ 
Sbjct: 666  LIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVN 725

Query: 1101 TPAKRHKQLKNKLE 1114
             P  R ++L+  +E
Sbjct: 726  FPKCRRRRLQKDIE 739


>gi|209863026 transient receptor potential cation channel, subfamily
            C, member 4 isoform beta [Homo sapiens]
          Length = 893

 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 134/638 (21%), Positives = 238/638 (37%), Gaps = 114/638 (17%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I   S+D    A   S  L+ELSK E +  S  E L+          L +    R + +
Sbjct: 208  LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
                YR D    ++      ++      L+LA++ +  +FV+    Q  L   W+ +   
Sbjct: 268  ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319

Query: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
              G  R    +      + GL+ F    +  +  P +    F   P + F  +  SY  F
Sbjct: 320  --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376

Query: 810  LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
            L L      ++   D     P P+  E  I  W+   +  E++Q++    + GL      
Sbjct: 377  LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428

Query: 863  YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906
            Y  D+WN +D     L++A ++ +++    Y                    + ++  I  
Sbjct: 429  YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488

Query: 907  CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966
             LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + E      
Sbjct: 489  SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548

Query: 967  FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011
             +G                +   + +IFG I  Y+  V    E                 
Sbjct: 549  CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591

Query: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071
                    F E++   +   Y + + ++LLN+LIAM N ++Q + +H D  WKF R  L 
Sbjct: 592  --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLW 643

Query: 1072 EEYHGRPAA-PPPFILL---SHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIY 1127
              Y       P PF ++     L   IK +        H   K    K E    +     
Sbjct: 644  MSYFEEGGTLPTPFNVIPSPKSLWYLIKWI------WTHLCKKKMRRKPESFGTIGRR-- 695

Query: 1128 LKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQT 1187
              +N  ++ Q+Q+  R         N V   V  +  D     G  E+    L++ ++  
Sbjct: 696  AADNLRRHHQYQEVMR---------NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSF 746

Query: 1188 ARALHWIVRTLRASGF-SSEADVPTLASQKAAEEPDAE 1224
               +  ++R  + S   S+ A   +  S  + E+ D+E
Sbjct: 747  RFEVLGLLRGSKLSTIQSANASKESSNSADSDEKSDSE 784


>gi|209863030 transient receptor potential cation channel, subfamily
            C, member 4 isoform delta [Homo sapiens]
          Length = 836

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 108/494 (21%), Positives = 188/494 (38%), Gaps = 93/494 (18%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I   S+D    A   S  L+ELSK E +  S  E L+          L +    R + +
Sbjct: 208  LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
                YR D    ++      ++      L+LA++ +  +FV+    Q  L   W+ +   
Sbjct: 268  ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319

Query: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
              G  R    +      + GL+ F    +  +  P +    F   P + F  +  SY  F
Sbjct: 320  --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376

Query: 810  LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
            L L      ++   D     P P+  E  I  W+   +  E++Q++    + GL      
Sbjct: 377  LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428

Query: 863  YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906
            Y  D+WN +D     L++A ++ +++    Y                    + ++  I  
Sbjct: 429  YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488

Query: 907  CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966
             LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + E      
Sbjct: 489  SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548

Query: 967  FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011
             +G                +   + +IFG I  Y+  V    E                 
Sbjct: 549  CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591

Query: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071
                    F E++   +   Y + + ++LLN+LIAM N ++Q + +H D  WKF R  L 
Sbjct: 592  --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLW 643

Query: 1072 EEYHGRPAA-PPPF 1084
              Y       P PF
Sbjct: 644  MSYFEEGGTLPTPF 657


>gi|4507685 transient receptor potential cation channel, subfamily C,
            member 1 [Homo sapiens]
          Length = 759

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/566 (22%), Positives = 224/566 (39%), Gaps = 81/566 (14%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I    +D I  A   S  LKELS  E +  +  E LA          LA+    R + V
Sbjct: 191  LIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEV 250

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
                   DE   ++ L    E     + L+LA++    +FVS    Q FL  VW+GQ+S 
Sbjct: 251  ILNHTSSDEPLDKRGLL---EERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMS- 306

Query: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
              G  R   C     +L  G I +    L  +  P ++       P + F ++  SYF F
Sbjct: 307  --GYRRKPTCKKIMTVLTVG-IFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTF 363

Query: 810  LCLFAYVLMV-------DFQPVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
            L L     +V          P     +  + LW+  ++  ++++L+Y+  E   ++++  
Sbjct: 364  LLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLE-DFLEESRN 422

Query: 863  YFSDFWNKLDVGAILLFVAG------LTCRLIPATLYPGRV---ILSLDFILFCLRLMHI 913
              S   N L +    L V           R      +P  V   + +   +L  LRL  +
Sbjct: 423  QLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFM 482

Query: 914  FTISKTLGPKIIIVKRMMKDV--FFFLFLLAVWVVSFGVA------------KQAILIHN 959
            +T S  LGP  I + +M++D   F  +FLL ++  + G+             K  + I  
Sbjct: 483  YTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFC 542

Query: 960  ERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPA 1019
            E++         +HS++     +  YI    F+  H +      +  +    +  Q    
Sbjct: 543  EQQ-----SNDTFHSFIGTCFALFWYI----FSLAHVA-----IFVTRFSYGEELQ---- 584

Query: 1020 FPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDL-IEEYHGRP 1078
               ++  +++  Y +   I+L  LL+AM + +FQ +  H D+ WKF R  L +  +  + 
Sbjct: 585  --SFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKC 642

Query: 1079 AAPPPF----------ILLSHLQLFIKRVVLKTPAKRHKQLK--NKLEKNEEAALLSWEI 1126
              PPPF           ++S L  +I     K   KR   LK    L++  +        
Sbjct: 643  TLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMC 702

Query: 1127 YLKENYLQNRQFQQKQRPEQKIEDIS 1152
             L   YL + + + +   +  +E+++
Sbjct: 703  CLVHRYLTSMRQKMQSTDQATVENLN 728


>gi|9966865 transient receptor potential cation channel, subfamily C,
            member 7 [Homo sapiens]
          Length = 862

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 124/565 (21%), Positives = 217/565 (38%), Gaps = 135/565 (23%)

Query: 638  AGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKD 697
            A  +   S+D +  AL  S  L  L+  E  T+   +   L+ + +   +GV   C  +D
Sbjct: 228  AAYLSLSSEDPVLTALELSNELARLANIE--TEFKNDYRKLSMQCKDFVVGVLDLC--RD 283

Query: 698  EERAQKLLTRVS--EAWG-----KTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVD 750
             E  + +L      + W        + ++LA++ +  KFV+H   Q  L  +W+  LS  
Sbjct: 284  TEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLS-- 341

Query: 751  NGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFL 810
             GL + ++ +  F  +    I      +     P ++      +P + F  + +S+  FL
Sbjct: 342  -GLRQQSIAV-KFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFL 399

Query: 811  CLFAYVLMVDFQPVP----------------------SWCECAIYLWLFSLVCEEMRQLF 848
             L        F+ V                       SW E  I  W+  ++  E ++++
Sbjct: 400  GLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIW 459

Query: 849  YD-PDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIP------ATLY-------- 893
             + P E         Y    WN LD G + +FVA  T R +       A LY        
Sbjct: 460  EEGPRE---------YVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDD 510

Query: 894  -------PGRV---------------------ILSLDFILFCLRLMHIFTISKTLGPKII 925
                   P  V                     + ++  +L   R+ +I   +++ GP  I
Sbjct: 511  TLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQI 570

Query: 926  IVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYH--------SYLT 977
             + R +KD+F F+ +  +  V+F +    +  +        +RGA Y+        S+ T
Sbjct: 571  SLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSY--------YRGAKYNPAFTTVEESFKT 622

Query: 978  IFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTN 1037
            +F  I G  + +                     S   +    F E +  +L  +Y +   
Sbjct: 623  LFWSIFGLSEVI---------------------SVVLKYDHKFIENIGYVLYGVYNVTMV 661

Query: 1038 ILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEY--HGRPAAPPPFILLS------H 1089
            ++LLN+LIAM N ++Q+++E  D  WKF R  L   Y   GR   P PF L+       +
Sbjct: 662  VVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGR-TLPAPFNLVPSPKSFYY 720

Query: 1090 LQLFIKRVVLKTPAKRHKQLKNKLE 1114
            L + IK  ++K    + K  +N LE
Sbjct: 721  LIMRIKMCLIKLCKSKAKSCENDLE 745


>gi|209863032 transient receptor potential cation channel, subfamily
            C, member 4 isoform zeta [Homo sapiens]
          Length = 804

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 103/496 (20%), Positives = 184/496 (37%), Gaps = 101/496 (20%)

Query: 784  PAARARAFFTAPVVVFHLNILSYFAFLCLFA----YVLMVDFQ---PVPSWCECAIYLWL 836
            P +    F   P + F  +  SY  FL L      ++   D     P P+  E  I  W+
Sbjct: 178  PKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWV 237

Query: 837  FSLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG- 895
               +  E++Q++    + GL      Y  D+WN +D     L++A ++ +++    Y   
Sbjct: 238  LGFIWGEIKQMW----DGGLQD----YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 289

Query: 896  ---------------RVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFL 940
                             + ++  I   LRL+ +FT +  LGP  I + RM+ D+  FLF+
Sbjct: 290  NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 349

Query: 941  LAVWVVSFGVAKQAILIHNERRVDWLFRG---------------AVYHSYLTIFGQIPGY 985
              + +++F      +  + E       +G                +   + +IFG I  Y
Sbjct: 350  YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLY 409

Query: 986  IDGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLI 1045
            +  V    E                         F E++   +   Y + + ++LLN+LI
Sbjct: 410  VTNVKAQHE-------------------------FTEFVGATMFGTYNVISLVVLLNMLI 444

Query: 1046 AMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAA-PPPFILL---SHLQLFIKRVVLKT 1101
            AM N ++Q + +H D  WKF R  L   Y       P PF ++     L   IK +    
Sbjct: 445  AMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWI---- 500

Query: 1102 PAKRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDL 1161
                H   K    K E    +       +N  ++ Q+Q+  R         N V   V  
Sbjct: 501  --WTHLCKKKMRRKPESFGTIGRR--AADNLRRHHQYQEVMR---------NLVKRYVAA 547

Query: 1162 LDLDPLKRSGSMEQRLASLEEQVAQTARALHWIVRTLRASGFSSEADVPTLASQKAAEEP 1221
            +  D     G  E+    L++ ++     +  ++R  + S         T+ S  A++E 
Sbjct: 548  MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLS---------TIQSANASKES 598

Query: 1222 DAEPGGRKKTEEPGDS 1237
                   +K++  G+S
Sbjct: 599  SNSADSDEKSDSEGNS 614


>gi|5730102 transient receptor potential cation channel, subfamily C,
            member 6 [Homo sapiens]
          Length = 931

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 125/591 (21%), Positives = 215/591 (36%), Gaps = 136/591 (23%)

Query: 645  SQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERA--- 701
            S+D +  AL  S  L  L+  E++  +  + L++  + +   +G+   C   +E  A   
Sbjct: 290  SEDPVMTALELSNELAVLANIEKEFKNDYKKLSM--QCKDFVVGLLDLCRNTEEVEAILN 347

Query: 702  --QKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLC 759
               + L          + L+LA++ +  KFV+H   Q  L  +W+  LS   GL + T+ 
Sbjct: 348  GDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLS---GLRQQTMA 404

Query: 760  MLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAFLCLFAYVLMV 819
            +  F ++L   I      L     P ++       P + F  +  S+  FL L       
Sbjct: 405  V-KFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAAD 463

Query: 820  DFQPVP----------------------SWCECAIYLWLFSLVCEEMRQLFYD-PDECGL 856
             F+                         SW E  I  W+  ++  E ++++   P E   
Sbjct: 464  RFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKE--- 520

Query: 857  MKKAALYFSDFWNKLDVGAILLFVAGLTCR------------------------------ 886
                  Y  + WN LD G + +F A    R                              
Sbjct: 521  ------YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGD 574

Query: 887  ------------------LIPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVK 928
                              +I   LY   V+LS        R+ +I   +++ GP  I + 
Sbjct: 575  NVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFS------RIAYILPANESFGPLQISLG 628

Query: 929  RMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGY--I 986
            R +KD+F F+ +  +  V+F +    +  +            V  S+ T+F  I G   +
Sbjct: 629  RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEV 688

Query: 987  DGVNFNPEHCSPNGTDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIA 1046
              V  N  H                        F E +  +L  +Y +   I+LLN+LIA
Sbjct: 689  KSVVINYNH-----------------------KFIENIGYVLYGVYNVTMVIVLLNMLIA 725

Query: 1047 MFNYTFQQVQEHTDQIWKFQRHDLIEEY--HGRPAAPPPFIL------LSHLQLFIKRVV 1098
            M N +FQ++++  D  WKF R  L   Y   GR   P PF L      L +L L +K+ +
Sbjct: 726  MINSSFQEIEDDADVEWKFARAKLWFSYFEEGR-TLPVPFNLVPSPKSLFYLLLKLKKWI 784

Query: 1099 LKTPAKRHKQLK-----NKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRP 1144
             +      K  +     NK+ + ++  +L     L +  L  +Q    ++P
Sbjct: 785  SELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQP 835


>gi|209863028 transient receptor potential cation channel, subfamily
            C, member 4 isoform gamma [Homo sapiens]
          Length = 828

 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 100/482 (20%), Positives = 181/482 (37%), Gaps = 94/482 (19%)

Query: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
            +I   S+D    A   S  L+ELSK E +  S  E L+          L +    R + +
Sbjct: 208  LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267

Query: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749
                YR D    ++      ++      L+LA++ +  +FV+    Q  L   W+ +   
Sbjct: 268  ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319

Query: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809
              G  R    +      + GL+ F    +  +  P +    F   P + F  +  SY  F
Sbjct: 320  --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376

Query: 810  LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862
            L L      ++   D     P P+  E  I  W+   +  E++Q++    + GL      
Sbjct: 377  LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428

Query: 863  YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906
            Y  D+WN +D     L++A ++ +++    Y                    + ++  I  
Sbjct: 429  YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488

Query: 907  CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966
             LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + E      
Sbjct: 489  SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548

Query: 967  FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011
             +G                +   + +IFG I  Y+  V    E                 
Sbjct: 549  CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591

Query: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071
                    F E++   +   Y + + ++LLN+LIAM N ++Q +          +RH   
Sbjct: 592  --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAAD--NLRRHHQY 641

Query: 1072 EE 1073
            +E
Sbjct: 642  QE 643


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,766,368
Number of Sequences: 37866
Number of extensions: 2798831
Number of successful extensions: 7529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 7224
Number of HSP's gapped (non-prelim): 175
length of query: 1503
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1388
effective length of database: 13,892,928
effective search space: 19283384064
effective search space used: 19283384064
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.