Search of human proteins with 4507515

Search of human proteins with 4507515

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507515 tissue inhibitor of metalloproteinase 4 precursor
[Homo sapiens]
         (224 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507515 tissue inhibitor of metalloproteinase 4 precursor [Ho...   479   e-135
gi|4507511 TIMP metallopeptidase inhibitor 2 precursor [Homo sap...   227   7e-60
gi|4507513 tissue inhibitor of metalloproteinase 3 precursor [Ho...   206   2e-53
gi|4507509 tissue inhibitor of metalloproteinase 1 precursor [Ho...   140   7e-34
gi|6806893 lymphotoxin alpha precursor [Homo sapiens]                  29   2.8  
gi|229092381 lymphotoxin alpha precursor [Homo sapiens]                29   2.8  
gi|169216384 PREDICTED: similar to hCG1805148 [Homo sapiens]           29   2.8  
gi|169216638 PREDICTED: similar to hCG1805148 [Homo sapiens]           29   2.8  
gi|61676193 zinc finger protein 260 [Homo sapiens]                     29   3.7  
gi|228480211 four and a half LIM domains 1 isoform 1 [Homo sapiens]    28   4.9  
gi|239582720 ATG9 autophagy related 9 homolog B [Homo sapiens]         28   4.9  
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ...    28   6.3  
gi|134031945 SCO-spondin [Homo sapiens]                                28   8.3  
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]         28   8.3  

>gi|4507515 tissue inhibitor of metalloproteinase 4 precursor [Homo
           sapiens]
          Length = 224

 Score =  479 bits (1232), Expect = e-135
 Identities = 224/224 (100%), Positives = 224/224 (100%)

Query: 1   MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA 60
           MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
Sbjct: 1   MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA 60

Query: 61  SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV 120
           SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV
Sbjct: 61  SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV 120

Query: 121 LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD 180
           LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD
Sbjct: 121 LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD 180

Query: 181 WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 224
           WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
Sbjct: 181 WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 224


>gi|4507511 TIMP metallopeptidase inhibitor 2 precursor [Homo
           sapiens]
          Length = 220

 Score =  227 bits (578), Expect = 7e-60
 Identities = 106/212 (50%), Positives = 148/212 (69%), Gaps = 6/212 (2%)

Query: 14  LLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPASADP-ADTEKMLR 72
           LL L  LLRP    +ACSC+P HPQQ  C++ +VIRAK  SEK V +  D   +  K ++
Sbjct: 14  LLLLATLLRP---ADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQ 70

Query: 73  YEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHLCN 132
           YEIKQIKMFKG EK  D+++IYT   S++CGV L+   +K+YL+ G+   DGK+ I LC+
Sbjct: 71  YEIKQIKMFKGPEK--DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCD 128

Query: 133 YIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTDWLLERKLYGYQA 192
           +I PW+ LS  Q++SLNH Y + C C+IT C  +PC IS+P+ECLW DW+ E+ + G+QA
Sbjct: 129 FIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQA 188

Query: 193 QHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 224
           + + C+K  DG+C+WYRG  P ++EF+DI  P
Sbjct: 189 KFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP 220


>gi|4507513 tissue inhibitor of metalloproteinase 3 precursor [Homo
           sapiens]
          Length = 211

 Score =  206 bits (523), Expect = 2e-53
 Identities = 103/214 (48%), Positives = 139/214 (64%), Gaps = 11/214 (5%)

Query: 15  LRLLALLRPPGLG----EACSCAPAHPQQHICHSALVIRAKISSEKVVPASADPADTEKM 70
           L L+ LL    LG    EAC+C+P+HPQ   C+S +VIRAK+  +K+V     P  T   
Sbjct: 5   LGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEG--PFGT--- 59

Query: 71  LRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHL 130
           L Y IKQ+KM++GF K+  VQYI+T    SLCG+KLE N   QYLLTG+V  DGK++  L
Sbjct: 60  LVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKY-QYLLTGRVY-DGKMYTGL 117

Query: 131 CNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTDWLLERKLYGY 190
           CN++E W+ L+L QR+ LN+ YHL C C+I +CY +PC +++ NECLWTD L      GY
Sbjct: 118 CNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGY 177

Query: 191 QAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP 224
           Q++HY C++   G CSWYRG  P  K  ++   P
Sbjct: 178 QSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP 211


>gi|4507509 tissue inhibitor of metalloproteinase 1 precursor [Homo
           sapiens]
          Length = 207

 Score =  140 bits (354), Expect = 7e-34
 Identities = 74/205 (36%), Positives = 109/205 (53%), Gaps = 15/205 (7%)

Query: 7   PAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPASADPAD 66
           P  S +LLL  L L+ P     AC+C P HPQ   C+S LVIRAK         + +   
Sbjct: 6   PLASGILLL--LWLIAP---SRACTCVPPHPQTAFCNSDLVIRAKF------VGTPEVNQ 54

Query: 67  TEKMLRYEIKQIKMFKGFEKV---KDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSD 123
           T    RYEIK  KM+KGF+ +    D++++YTP   S+CG    ++++ +  L    L D
Sbjct: 55  TTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQD 114

Query: 124 GKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNC-GCQITTCYTVPCTISAPNECLWTDWL 182
           G + I  C+++ PW  LSL QR      Y + C  C +  C ++PC + +   CLWTD L
Sbjct: 115 GLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQL 174

Query: 183 LERKLYGYQAQHYVCMKHVDGTCSW 207
           L+    G+Q++H  C+    G C+W
Sbjct: 175 LQGSEKGFQSRHLACLPREPGLCTW 199


>gi|6806893 lymphotoxin alpha precursor [Homo sapiens]
          Length = 205

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 8/43 (18%)

Query: 12 VLLLRLLALLRP-----PGLG---EACSCAPAHPQQHICHSAL 46
          +LLL LL +L P     PG+G    A   A  HP+ H+ HS L
Sbjct: 19 LLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTL 61


>gi|229092381 lymphotoxin alpha precursor [Homo sapiens]
          Length = 205

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 8/43 (18%)

Query: 12 VLLLRLLALLRP-----PGLG---EACSCAPAHPQQHICHSAL 46
          +LLL LL +L P     PG+G    A   A  HP+ H+ HS L
Sbjct: 19 LLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTL 61


>gi|169216384 PREDICTED: similar to hCG1805148 [Homo sapiens]
          Length = 476

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 8/82 (9%)

Query: 149 NHHYHLNCGCQITTCYTVPCTISAPN----ECLWTDWLLERKLYGYQAQHY---VCMKHV 201
           NH Y+ +C C IT C  V CT  A      + L  +W   R    +Q+  +      +  
Sbjct: 67  NHDYY-SCNCNITPCRVVRCTQEAKEGNLIKLLSKEWGAVRDSVVFQSTVFKLKETQQCT 125

Query: 202 DGTCSWYRGHLPLRKEFVDIVQ 223
           DG    +  H P   +   I++
Sbjct: 126 DGDVIRHASHAPFHAQAAGIIK 147


>gi|169216638 PREDICTED: similar to hCG1805148 [Homo sapiens]
          Length = 476

 Score = 29.3 bits (64), Expect = 2.8
 Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 8/82 (9%)

Query: 149 NHHYHLNCGCQITTCYTVPCTISAPN----ECLWTDWLLERKLYGYQAQHY---VCMKHV 201
           NH Y+ +C C IT C  V CT  A      + L  +W   R    +Q+  +      +  
Sbjct: 67  NHDYY-SCNCNITPCRVVRCTQEAKEGNLIKLLSKEWGAVRDSVVFQSTVFKLKETQQCT 125

Query: 202 DGTCSWYRGHLPLRKEFVDIVQ 223
           DG    +  H P   +   I++
Sbjct: 126 DGDVIRHASHAPFHAQAAGIIK 147


>gi|61676193 zinc finger protein 260 [Homo sapiens]
          Length = 412

 Score = 28.9 bits (63), Expect = 3.7
 Identities = 19/50 (38%), Positives = 27/50 (54%), Gaps = 6/50 (12%)

Query: 79  KMFKGFEKVKDVQYIYT---PFDSSLCGVKLEANSQKQYLLTGQVLSDGK 125
           K F G   + + + I+T   PF+ + CG    A SQKQYL+  Q +  GK
Sbjct: 143 KAFNGKAYLTEHEKIHTGEKPFECNQCG---RAFSQKQYLIKHQNIHTGK 189


>gi|228480211 four and a half LIM domains 1 isoform 1 [Homo sapiens]
          Length = 323

 Score = 28.5 bits (62), Expect = 4.9
 Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 4/32 (12%)

Query: 2   PGSPRPAPSWVLLL----RLLALLRPPGLGEA 29
           PG  R  PSWV++L    R LA  R PGL +A
Sbjct: 270 PGGERTCPSWVVVLYRKNRSLAAPRGPGLVKA 301


>gi|239582720 ATG9 autophagy related 9 homolog B [Homo sapiens]
          Length = 924

 Score = 28.5 bits (62), Expect = 4.9
 Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 3/46 (6%)

Query: 23  PPGLGEACSCAPAHPQQHICHSALVIRAKISSE---KVVPASADPA 65
           PP  G  CS          CHSAL I A   ++    + PASA P+
Sbjct: 68  PPTAGPPCSVLQGTGASQSCHSALPIPATPPTQAQPAMTPASASPS 113


>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
          sapiens]
          Length = 2923

 Score = 28.1 bits (61), Expect = 6.3
 Identities = 15/26 (57%), Positives = 16/26 (61%)

Query: 3  GSPRPAPSWVLLLRLLALLRPPGLGE 28
          G P P P   LLL LL LL PP LG+
Sbjct: 7  GVPLPTPPPPLLLLLLLLLPPPLLGD 32


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 9/19 (47%), Positives = 12/19 (63%), Gaps = 4/19 (21%)

Query: 163  CYTVPCTISAPNECLWTDW 181
            CY+ PC    P EC+W+ W
Sbjct: 4357 CYSGPC----PEECVWSSW 4371


>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
          Length = 888

 Score = 27.7 bits (60), Expect = 8.3
 Identities = 23/98 (23%), Positives = 39/98 (39%)

Query: 7   PAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPASADPAD 66
           P P   LL   +    PPG   A + A   P+     +  +   +  +   V  +  P  
Sbjct: 398 PLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVYVAIYPYT 457

Query: 67  TEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGV 104
             K    E+++ +MF  FE+ +D  +  T   +S  GV
Sbjct: 458 PRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGV 495


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,072,445
Number of Sequences: 37866
Number of extensions: 470043
Number of successful extensions: 1097
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1082
Number of HSP's gapped (non-prelim): 20
length of query: 224
length of database: 18,247,518
effective HSP length: 98
effective length of query: 126
effective length of database: 14,536,650
effective search space: 1831617900
effective search space used: 1831617900
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.