Guide to the Human Genome
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Search of human proteins with 4507373

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507373 beta-tubulin cofactor C [Homo sapiens]
         (346 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507373 beta-tubulin cofactor C [Homo sapiens]                     689   0.0  
gi|170016081 XRP2 protein [Homo sapiens]                              104   1e-22
gi|197313654 TBCC domain containing 1 [Homo sapiens]                   46   4e-05
gi|8922517 TBCC domain containing 1 [Homo sapiens]                     46   4e-05
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...    41   0.002
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...    41   0.002
gi|56549694 enabled homolog isoform a [Homo sapiens]                   40   0.002
gi|39930375 enabled homolog isoform b [Homo sapiens]                   40   0.002
gi|239746974 PREDICTED: hypothetical protein XP_002343900 [Homo ...    40   0.003
gi|239746972 PREDICTED: hypothetical protein XP_002343899 [Homo ...    40   0.003
gi|239746970 PREDICTED: hypothetical protein XP_002343898 [Homo ...    40   0.003
gi|187607308 paraneoplastic antigen like 6A [Homo sapiens]             40   0.003
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    39   0.005
gi|148746195 trichohyalin [Homo sapiens]                               39   0.007
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    39   0.007
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    39   0.007
gi|19913396 smoothelin isoform b [Homo sapiens]                        39   0.009
gi|19913394 smoothelin isoform c [Homo sapiens]                        39   0.009
gi|19913398 smoothelin isoform a [Homo sapiens]                        39   0.009
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...    38   0.012
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...    38   0.012
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...    38   0.012
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...    38   0.012
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             38   0.015
gi|116488398 keratin 32 [Homo sapiens]                                 37   0.020
gi|197333879 genetic suppressor element 1 isoform 2 [Homo sapiens]     37   0.020
gi|44955926 genetic suppressor element 1 isoform 1 [Homo sapiens]      37   0.020
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    37   0.026
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    37   0.026
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    37   0.026

>gi|4507373 beta-tubulin cofactor C [Homo sapiens]
          Length = 346

 Score =  689 bits (1779), Expect = 0.0
 Identities = 346/346 (100%), Positives = 346/346 (100%)

Query: 1   MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFF 60
           MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFF
Sbjct: 1   MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFF 60

Query: 61  VATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARL 120
           VATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARL
Sbjct: 61  VATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARL 120

Query: 121 QAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGP 180
           QAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGP
Sbjct: 121 QAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGP 180

Query: 181 SWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPV 240
           SWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPV
Sbjct: 181 SWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPV 240

Query: 241 STSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEID 300
           STSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEID
Sbjct: 241 STSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEID 300

Query: 301 KDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD 346
           KDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD
Sbjct: 301 KDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD 346


>gi|170016081 XRP2 protein [Homo sapiens]
          Length = 350

 Score =  104 bits (260), Expect = 1e-22
 Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 3/154 (1%)

Query: 186 FSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVF 245
           FS L+ + + +    +  +  L+ +  NC + ++ +  T+ +    +C +  GPV  SVF
Sbjct: 42  FSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVF 101

Query: 246 LEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFES 305
             +C DC   +ACQQ R+   +   +FL   ++ I+E  S I+F  + W YPE+   F+ 
Sbjct: 102 FRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKD 161

Query: 306 SGLDRSKNNWNDVDDFNWLARDMASPNWSILPEE 339
           +GL    N W+++ DF  ++ ++   NWS+LPE+
Sbjct: 162 AGLSIFNNTWSNIHDFTPVSGEL---NWSLLPED 192


>gi|197313654 TBCC domain containing 1 [Homo sapiens]
          Length = 557

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 32/134 (23%), Positives = 57/134 (42%), Gaps = 5/134 (3%)

Query: 187 SNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFL 246
           S +  Q L K +  L    V +   +   + L     ++ + K  +   + GPV T++ L
Sbjct: 313 SQVYKQTLAKSSDTLAGAHVKIHRCNESFIYLLSPLRSVTIEKCRNSIFVLGPVGTTLHL 372

Query: 247 EDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQ---FAPYTWSYPEIDKDF 303
             C +  +   C +L I ST      +   +R ++   SG Q   FAP+   YP ++   
Sbjct: 373 HSCDNVKVIAVCHRLSISSTTGCIFHVLTPTRPLI--LSGNQTVTFAPFHTHYPMLEDHM 430

Query: 304 ESSGLDRSKNNWND 317
             +GL    N W++
Sbjct: 431 ARTGLATVPNYWDN 444


>gi|8922517 TBCC domain containing 1 [Homo sapiens]
          Length = 557

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 32/134 (23%), Positives = 57/134 (42%), Gaps = 5/134 (3%)

Query: 187 SNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFL 246
           S +  Q L K +  L    V +   +   + L     ++ + K  +   + GPV T++ L
Sbjct: 313 SQVYKQTLAKSSDTLAGAHVKIHRCNESFIYLLSPLRSVTIEKCRNSIFVLGPVGTTLHL 372

Query: 247 EDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQ---FAPYTWSYPEIDKDF 303
             C +  +   C +L I ST      +   +R ++   SG Q   FAP+   YP ++   
Sbjct: 373 HSCDNVKVIAVCHRLSISSTTGCIFHVLTPTRPLI--LSGNQTVTFAPFHTHYPMLEDHM 430

Query: 304 ESSGLDRSKNNWND 317
             +GL    N W++
Sbjct: 431 ARTGLATVPNYWDN 444


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 36/149 (24%), Positives = 72/149 (48%), Gaps = 8/149 (5%)

Query: 30  QRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE--A 87
           +++EQ R+LE ++R++K   ++ E+E    +     RE        E+    ++LEE   
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQ 456

Query: 88  ASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAA 147
           A RLQ  ++L  +  + ++    RQ Q  + +    L   + G+ P ++ A+  +  +  
Sbjct: 457 AERLQ--RQLKQERDYLVSLQHQRQEQRPVEK--KPLYHYKEGMSPSEKPAW-AKEVEER 511

Query: 148 SSTKVDAAPGIPPAVES-IQDSPLPKKAE 175
           S     ++P +P  V + I D  LP ++E
Sbjct: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSE 540


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 36/149 (24%), Positives = 72/149 (48%), Gaps = 8/149 (5%)

Query: 30  QRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE--A 87
           +++EQ R+LE ++R++K   ++ E+E    +     RE        E+    ++LEE   
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQ 456

Query: 88  ASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAA 147
           A RLQ  ++L  +  + ++    RQ Q  + +    L   + G+ P ++ A+  +  +  
Sbjct: 457 AERLQ--RQLKQERDYLVSLQHQRQEQRPVEK--KPLYHYKEGMSPSEKPAW-AKEVEER 511

Query: 148 SSTKVDAAPGIPPAVES-IQDSPLPKKAE 175
           S     ++P +P  V + I D  LP ++E
Sbjct: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSE 540


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 42/120 (35%), Positives = 57/120 (47%), Gaps = 28/120 (23%)

Query: 17  ESQRDLSLVPERLQRREQERQ------LEVERRKQKRQNQE-VEKENSHFFVATFARERA 69
           E QR   L  ERL+R   ER+      LE ER +++R  QE +E+E          RER 
Sbjct: 149 EQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE-------RER- 200

Query: 70  AVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
             +E LER E +ER E    RL+  ++L  +          RQ +E L RL+    ER R
Sbjct: 201 --QERLERQERLERQE----RLERQERLDRER-------QERQERERLERLERERQERER 247



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 16/38 (42%), Positives = 26/38 (68%), Gaps = 1/38 (2%)

Query: 19  QRDLSLVPERLQRREQERQLEVERRKQKRQNQE-VEKE 55
           +R   L  ER +R+E+ER   +ER +Q+R+ QE +E+E
Sbjct: 217 ERQERLDRERQERQERERLERLERERQERERQEQLERE 254



 Score = 28.5 bits (62), Expect = 9.2
 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 19/72 (26%)

Query: 27  ERLQRREQ-ERQLEVERRKQKRQNQE----VEKENSHFFVATFARERAAVEELLERA--- 78
           ERL+R+E+ ERQ  ++R +Q+RQ +E    +E+E          RER   +E LER    
Sbjct: 208 ERLERQERLERQERLDRERQERQERERLERLERERQE-------RER---QEQLEREQLE 257

Query: 79  -ESVERLEEAAS 89
            E   R+  AA+
Sbjct: 258 WERERRISSAAA 269


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 42/120 (35%), Positives = 57/120 (47%), Gaps = 28/120 (23%)

Query: 17  ESQRDLSLVPERLQRREQERQ------LEVERRKQKRQNQE-VEKENSHFFVATFARERA 69
           E QR   L  ERL+R   ER+      LE ER +++R  QE +E+E          RER 
Sbjct: 149 EQQRQKELERERLERERMERERLERERLERERLERERLEQEQLERERQE-------RER- 200

Query: 70  AVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
             +E LER E +ER E    RL+  ++L  +          RQ +E L RL+    ER R
Sbjct: 201 --QERLERQERLERQE----RLERQERLDRER-------QERQERERLERLERERQERER 247



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 16/38 (42%), Positives = 26/38 (68%), Gaps = 1/38 (2%)

Query: 19  QRDLSLVPERLQRREQERQLEVERRKQKRQNQE-VEKE 55
           +R   L  ER +R+E+ER   +ER +Q+R+ QE +E+E
Sbjct: 217 ERQERLDRERQERQERERLERLERERQERERQEQLERE 254



 Score = 28.5 bits (62), Expect = 9.2
 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 19/72 (26%)

Query: 27  ERLQRREQ-ERQLEVERRKQKRQNQE----VEKENSHFFVATFARERAAVEELLERA--- 78
           ERL+R+E+ ERQ  ++R +Q+RQ +E    +E+E          RER   +E LER    
Sbjct: 208 ERLERQERLERQERLDRERQERQERERLERLERERQE-------RER---QEQLEREQLE 257

Query: 79  -ESVERLEEAAS 89
            E   R+  AA+
Sbjct: 258 WERERRISSAAA 269


>gi|239746974 PREDICTED: hypothetical protein XP_002343900 [Homo
           sapiens]
          Length = 399

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 45/155 (29%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 6   CSAAAVRT-GDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATF 64
           C AA  +  GD ESQ  + +     Q++  ER      R +    + +EKE     +A  
Sbjct: 224 CLAALAQVFGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEA----LARA 279

Query: 65  ARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAAL 124
           + +R  + ++L RA   E L+EA  +L    ++   S  FL    L +  EA    +A+L
Sbjct: 280 SADRVRLRQMLTRAHLTEPLDEALRKL----RMAGRSPSFLEMLGLVRESEAW---EASL 332

Query: 125 AERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIP 159
           A   R    +   A       A +STKV+A PG P
Sbjct: 333 ARSVRAQTQEGAGARAGAQAVARASTKVEAVPGGP 367


>gi|239746972 PREDICTED: hypothetical protein XP_002343899 [Homo
           sapiens]
          Length = 399

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 45/155 (29%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 6   CSAAAVRT-GDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATF 64
           C AA  +  GD ESQ  + +     Q++  ER      R +    + +EKE     +A  
Sbjct: 224 CLAALAQVFGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEA----LARA 279

Query: 65  ARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAAL 124
           + +R  + ++L RA   E L+EA  +L    ++   S  FL    L +  EA    +A+L
Sbjct: 280 SADRVRLRQMLTRAHLTEPLDEALRKL----RMAGRSPSFLEMLGLVRESEAW---EASL 332

Query: 125 AERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIP 159
           A   R    +   A       A +STKV+A PG P
Sbjct: 333 ARSVRAQTQEGAGARAGAQAVARASTKVEAVPGGP 367


>gi|239746970 PREDICTED: hypothetical protein XP_002343898 [Homo
           sapiens]
          Length = 399

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 45/155 (29%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 6   CSAAAVRT-GDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATF 64
           C AA  +  GD ESQ  + +     Q++  ER      R +    + +EKE     +A  
Sbjct: 224 CLAALAQVFGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEA----LARA 279

Query: 65  ARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAAL 124
           + +R  + ++L RA   E L+EA  +L    ++   S  FL    L +  EA    +A+L
Sbjct: 280 SADRVRLRQMLTRAHLTEPLDEALRKL----RMAGRSPSFLEMLGLVRESEAW---EASL 332

Query: 125 AERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIP 159
           A   R    +   A       A +STKV+A PG P
Sbjct: 333 ARSVRAQTQEGAGARAGAQAVARASTKVEAVPGGP 367


>gi|187607308 paraneoplastic antigen like 6A [Homo sapiens]
          Length = 399

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 45/155 (29%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 6   CSAAAVRT-GDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATF 64
           C AA  +  GD ESQ  + +     Q++  ER      R +    + +EKE     +A  
Sbjct: 224 CLAALAQVFGDNESQATIRVKCLTAQQQSGERLSAFVLRLEVLLQKAMEKEA----LARA 279

Query: 65  ARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAAL 124
           + +R  + ++L RA   E L+EA  +L    ++   S  FL    L +  EA    +A+L
Sbjct: 280 SADRVRLRQMLTRAHLTEPLDEALRKL----RMAGRSPSFLEMLGLVRESEAW---EASL 332

Query: 125 AERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIP 159
           A   R    +   A       A +STKV+A PG P
Sbjct: 333 ARSVRAQTQEGAGARAGAQAVARASTKVEAVPGGP 367


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 46/167 (27%), Positives = 74/167 (44%), Gaps = 25/167 (14%)

Query: 18   SQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLER 77
            +Q    L   R Q +  ++QL+ +  KQ   NQE+  EN  + V    RE  ++++ L+ 
Sbjct: 1252 AQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEM--ENLKWEVDQKEREIQSLKQQLDL 1309

Query: 78   AESVERLEEAASRLQGLQKLIND--SVFFLAAYDLRQGQEALARLQAALAERRRGLQ--- 132
             E   R E     L+GLQ+L+ +  S   +A  DL   Q+    LQA ++E +  ++   
Sbjct: 1310 TEQQGRKE-----LEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364

Query: 133  --------PKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLP 171
                      +R A KTR        K +A+   P     I D P+P
Sbjct: 1365 QQNQQLKLDLRRGAAKTR-----KEPKGEASSSNPATPIKIPDCPVP 1406


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 25/76 (32%), Positives = 42/76 (55%), Gaps = 6/76 (7%)

Query: 27  ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAES------ 80
           E+L +RE+E++LE ERR+Q+ + ++ E+ +         R++    E  ER E       
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606

Query: 81  VERLEEAASRLQGLQK 96
           VERLE+   R Q L++
Sbjct: 607 VERLEQEERREQRLKR 622



 Score = 36.6 bits (83), Expect = 0.034
 Identities = 34/130 (26%), Positives = 61/130 (46%), Gaps = 6/130 (4%)

Query: 27  ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE 86
           +RL+R E ER  + ERR+Q+ + +E E+E     + +  +E    ++L  R E  ER E+
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL--RREQQERREQ 657

Query: 87  AASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDA 146
              R +  ++L  +        + R+ QE     Q    ER +   PK ++  ++     
Sbjct: 658 RLKREEEEERL--EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD-- 713

Query: 147 ASSTKVDAAP 156
           A  +KV + P
Sbjct: 714 ARQSKVYSRP 723



 Score = 36.2 bits (82), Expect = 0.044
 Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 9/113 (7%)

Query: 17   ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
            E ++ L   PE+ +R+E+ERQ   E   Q+ + Q + +E          R+    EE+ +
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148

Query: 77   RAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
              E + R E    R Q L++   +        +L+Q +E L R +    E+RR
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREE------EELQQEEEQLLREE---QEKRR 1192



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 26/77 (33%), Positives = 38/77 (49%), Gaps = 9/77 (11%)

Query: 16  MESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELL 75
           +  QR+  L  E  Q+REQ R L  E  K++R+ Q  E+E    F+          EE L
Sbjct: 790 LREQRERQLRAEERQQREQ-RFLPEEEEKEQRRRQRREREKELQFLEE--------EEQL 840

Query: 76  ERAESVERLEEAASRLQ 92
           +R E  ++L+E    LQ
Sbjct: 841 QRRERAQQLQEEEDGLQ 857



 Score = 33.1 bits (74), Expect = 0.38
 Identities = 19/78 (24%), Positives = 38/78 (48%)

Query: 15  DMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEEL 74
           + + +R+  L  E+  RREQ+ + E + R+++ + +  +K           RE+    + 
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457

Query: 75  LERAESVERLEEAASRLQ 92
           L+R E  ER E+   + Q
Sbjct: 458 LKREEETERHEQERRKQQ 475



 Score = 32.7 bits (73), Expect = 0.49
 Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 8/120 (6%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E ++ L    E+ +RR+Q+ + E + R+++R  +E E+E     +     E    +EL E
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 77  RAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKR 136
             +   R E   SR+   Q  +          D RQ  +  +R +    +RRR  Q +KR
Sbjct: 688 EEQEQAR-ERIKSRIPKWQWQLESEA------DARQ-SKVYSRPRKQEGQRRRQEQEEKR 739



 Score = 32.3 bits (72), Expect = 0.64
 Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 5/116 (4%)

Query: 19  QRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERA 78
           QR  +  P R QR  Q R  E ++R+Q+   +E EKE          RER    + LE  
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR----RQRREREKELQFLEEE 837

Query: 79  ESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPK 134
           E ++R  E A +LQ  +  + +      + + R+ Q+   +L+     RR  L  K
Sbjct: 838 EQLQR-RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892



 Score = 32.3 bits (72), Expect = 0.64
 Identities = 23/104 (22%), Positives = 45/104 (43%)

Query: 26   PERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLE 85
            PE+ +R+E+E++   E   Q+ + Q + +E        + R+    +EL +  E + R E
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037

Query: 86   EAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
                RLQ  ++   +        +   G+E   R +  L  + R
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081



 Score = 32.0 bits (71), Expect = 0.84
 Identities = 34/124 (27%), Positives = 56/124 (45%), Gaps = 12/124 (9%)

Query: 15  DMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQE--VEKENSHFFVATFARERAAVE 72
           + E +RD     E  +R EQER+ +  +R Q+ + +E  ++ E          RE+    
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509

Query: 73  ELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQ 132
           E  ER E   + +E   RLQ  Q+L ++         LR+ QE   R Q    E  + L+
Sbjct: 510 EQEERREQRLKRQEEEERLQ--QRLRSEQ-------QLRREQEE-RREQLLKREEEKRLE 559

Query: 133 PKKR 136
            ++R
Sbjct: 560 QERR 563



 Score = 32.0 bits (71), Expect = 0.84
 Identities = 29/105 (27%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 27  ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVAT---FARERAAVEELLERAESVER 83
           E+ +RREQ+ + E E R+++R  ++ E+E     + +     RE+    E L + E  +R
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557

Query: 84  LEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERR 128
           LE+   R Q L++   +    L   +  + Q+ L R Q    E+R
Sbjct: 558 LEQ-ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 8/88 (9%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVE---RRKQKRQNQEVEKENSHFFVATFARER 68
           R    E +R+  L  E+ +RREQ+ + E E   R +Q R+ QE E+           RE+
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ-----LRREQ 381

Query: 69  AAVEELLERAESVERLEEAASRLQGLQK 96
               E   R E   R E+   R Q L++
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRR 409



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 22/82 (26%), Positives = 41/82 (50%)

Query: 15  DMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEEL 74
           + + +R+  L  E+  RREQ+ + E + R++++  +E E+E          RE+    E 
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 75  LERAESVERLEEAASRLQGLQK 96
            ER + ++R EE     Q  +K
Sbjct: 452 EERRDWLKREEETERHEQERRK 473



 Score = 31.2 bits (69), Expect = 1.4
 Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 17/83 (20%)

Query: 23  SLVPERLQRREQ------ERQLEVE---RRKQKRQNQEVEKENSHFFVATFARERAAVEE 73
           SL+ +R Q  +Q      +RQLE E   RR+QKRQ QE E             E++  +E
Sbjct: 108 SLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE--------GEEQSEKQE 159

Query: 74  LLERAESVERLEEAASRLQGLQK 96
            LE+ +   R EE   + Q  Q+
Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQE 182



 Score = 31.2 bits (69), Expect = 1.4
 Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 15/135 (11%)

Query: 17   ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEE--L 74
            E +R      ++L+R+E ++QL  ER ++ R+++++ +E     +    R+R  +EE   
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651

Query: 75   LERAESVERLEEAASRL-------------QGLQKLINDSVFFLAAYDLRQGQEALARLQ 121
            L R E  ++L     R              Q L++   D  F      LR+ +     LQ
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711

Query: 122  AALAERRRGLQPKKR 136
                 RR+ L+ K R
Sbjct: 1712 EEQQLRRQELERKFR 1726



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 30/125 (24%), Positives = 57/125 (45%), Gaps = 11/125 (8%)

Query: 15   DMESQRDLSLVPERLQRR--EQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVE 72
            +++ + +  L  ER +RR  E+ERQ   E   Q+ + Q + +E          R+    E
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084

Query: 73   ELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQ 132
            EL +  E + R E    R Q  ++   +        +L+Q +E L R +    E+RR  +
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREE------EELQQEEEQLLREE---REKRRRQE 1135

Query: 133  PKKRF 137
             ++++
Sbjct: 1136 LERQY 1140



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 20/80 (25%), Positives = 35/80 (43%), Gaps = 1/80 (1%)

Query: 12   RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFF-VATFARERAA 70
            R      + +L    E+L R E+E++   E  +Q R+ +EV++E           R R  
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165

Query: 71   VEELLERAESVERLEEAASR 90
            +E      E +++ EE   R
Sbjct: 1166 LERQYREEEELQQEEEQLLR 1185



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 26/91 (28%), Positives = 48/91 (52%), Gaps = 8/91 (8%)

Query: 15   DMESQRDLS-LVPERLQR-REQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVE 72
            D +SQ+DL  L+ E+ +R REQER+   +R +   + +++E+E          R+R + E
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK---EAKRRDRKSQE 1316

Query: 73   E---LLERAESVERLEEAASRLQGLQKLIND 100
            E   L E  E   R +E   + +  ++L+ +
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQLLQE 1347



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 2/77 (2%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           + Q+ L    E LQR E+E++   E+ +Q R+ +++++E     +    RE+   +E   
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ--LLREEREKRRRQERER 958

Query: 77  RAESVERLEEAASRLQG 93
           +    ++L++   +L G
Sbjct: 959 QYRKDKKLQQKEEQLLG 975



 Score = 29.6 bits (65), Expect = 4.1
 Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 5/69 (7%)

Query: 30  QRREQE--RQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEEA 87
           +RREQ+  R+ + ERR+Q+ + ++ E+           +E    E+ L R +  ER E+ 
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQL---RREQEEERREQQLRREQEEERREQQ 376

Query: 88  ASRLQGLQK 96
             R Q L++
Sbjct: 377 LRREQQLRR 385



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 2/80 (2%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E  R L     R +R+E+E+Q +  RR+Q+ + ++ E+           +ER   +E  E
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE--E 333

Query: 77  RAESVERLEEAASRLQGLQK 96
           R E   R E+   R Q L++
Sbjct: 334 RREQQLRREQEERREQQLRR 353



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 4/82 (4%)

Query: 15  DMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEK-ENSHFFVATFARERAAVE- 72
           + E +RD  L  E  +R+++ ++ + ER +Q+ + +EVE+ E          RE    E 
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 73  --ELLERAESVERLEEAASRLQ 92
             +LL+  E  ER ++   R Q
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQ 651



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 26/110 (23%), Positives = 52/110 (47%), Gaps = 10/110 (9%)

Query: 27   ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE 86
            E+ +R+E+ERQ   +++ Q+++ Q + +E          ++    EEL +  E + R E 
Sbjct: 949  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008

Query: 87   AASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKR 136
               R Q  ++       +    +L+Q +E L R +      +R LQ ++R
Sbjct: 1009 EKRRRQEWERQ------YRKKDELQQEEEQLLREE----REKRRLQERER 1048



 Score = 28.9 bits (63), Expect = 7.1
 Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 14/122 (11%)

Query: 19  QRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERA 78
           QRD     E L R+ QE Q   ERR ++ Q Q  +   +         E    EE L R 
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET---------EEFPDEEQLRRR 213

Query: 79  ESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALAR-----LQAALAERRRGLQP 133
           E +E   +     Q  ++   D VF        + +E + R     LQ    +R+R LQ 
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273

Query: 134 KK 135
           ++
Sbjct: 274 EE 275



 Score = 28.9 bits (63), Expect = 7.1
 Identities = 21/74 (28%), Positives = 35/74 (47%), Gaps = 20/74 (27%)

Query: 27  ERLQRREQERQLEV----------ERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E+LQ  E +RQ E+          ER++ +R+ QE E++          ++R   E+ L 
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ----------QQRLRREQQLR 307

Query: 77  RAESVERLEEAASR 90
           R +  ER E+   R
Sbjct: 308 RKQEEERREQQEER 321


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 9/125 (7%)

Query: 2   ESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFV 61
           E +  +A A R  +   Q          +RREQER+ E ERR+Q+RQ  E E+       
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERR-EQERREQERQLAEQERRRE---- 727

Query: 62  ATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQ 121
               +ER   E  L+  E   RL++   + +  +K   +    LA   L++ QE  A+  
Sbjct: 728 ----QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783

Query: 122 AALAE 126
           A  ++
Sbjct: 784 AGASK 788



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 33/115 (28%), Positives = 55/115 (47%), Gaps = 16/115 (13%)

Query: 29  LQRREQERQLEVERRKQKRQ-----NQEVEKENSHFFVATFARERAAVEELLERAESVER 83
           LQ RE+  Q++ E++KQ  Q     +++ EK          A+++AA ++ +E  E+  +
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK-MEEVEARRK 640

Query: 84  LEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFA 138
            EE A RL+ LQ+            + R+ QE L + +    ER R     KR A
Sbjct: 641 QEEEARRLRWLQQ----------EEEERRHQELLQKKKEEEQERLRKAAEAKRLA 685



 Score = 37.0 bits (84), Expect = 0.026
 Identities = 48/168 (28%), Positives = 75/168 (44%), Gaps = 21/168 (12%)

Query: 15  DMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEEL 74
           + E  R  +      ++REQER+ E ERR+Q+R+ QE  ++          +ER   E+ 
Sbjct: 671 EQERLRKAAEAKRLAEQREQERR-EQERREQERREQERREQERR------EQERQLAEQ- 722

Query: 75  LERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARL--QAALAERRRGLQ 132
            ER    ERL +A   LQ  +K +      L    L++  E   +   Q  LAER+   +
Sbjct: 723 -ERRREQERL-QAERELQEREKALR-----LQKEQLQRELEEKKKKEEQQRLAERQLQEE 775

Query: 133 PKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGP 180
            +K+ A +  G   A +  VD      PA  S Q +P   +A   + P
Sbjct: 776 QEKK-AKEAAGASKALNVTVDVQ---SPACTSYQMTPQGHRAPPKINP 819



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 38/134 (28%), Positives = 63/134 (47%), Gaps = 6/134 (4%)

Query: 2   ESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFV 61
           E     AAA +  ++E++R       RL+  +QE   E ERR Q+   ++ E+E      
Sbjct: 621 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE---EEERRHQELLQKKKEEEQERLRK 677

Query: 62  ATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQ 121
           A  A+ R A +   ER E  ER E+     +  ++   +    LA  + R+ QE L + +
Sbjct: 678 AAEAK-RLAEQREQERREQ-ERREQERREQERREQERREQERQLAEQERRREQERL-QAE 734

Query: 122 AALAERRRGLQPKK 135
             L ER + L+ +K
Sbjct: 735 RELQEREKALRLQK 748


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 9/125 (7%)

Query: 2   ESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFV 61
           E +  +A A R  +   Q          +RREQER+ E ERR+Q+RQ  E E+       
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERR-EQERREQERQLAEQERRRE---- 723

Query: 62  ATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQ 121
               +ER   E  L+  E   RL++   + +  +K   +    LA   L++ QE  A+  
Sbjct: 724 ----QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779

Query: 122 AALAE 126
           A  ++
Sbjct: 780 AGASK 784



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 33/115 (28%), Positives = 55/115 (47%), Gaps = 16/115 (13%)

Query: 29  LQRREQERQLEVERRKQKRQ-----NQEVEKENSHFFVATFARERAAVEELLERAESVER 83
           LQ RE+  Q++ E++KQ  Q     +++ EK          A+++AA ++ +E  E+  +
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK-MEEVEARRK 636

Query: 84  LEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFA 138
            EE A RL+ LQ+            + R+ QE L + +    ER R     KR A
Sbjct: 637 QEEEARRLRWLQQ----------EEEERRHQELLQKKKEEEQERLRKAAEAKRLA 681



 Score = 37.0 bits (84), Expect = 0.026
 Identities = 48/168 (28%), Positives = 75/168 (44%), Gaps = 21/168 (12%)

Query: 15  DMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEEL 74
           + E  R  +      ++REQER+ E ERR+Q+R+ QE  ++          +ER   E+ 
Sbjct: 667 EQERLRKAAEAKRLAEQREQERR-EQERREQERREQERREQERR------EQERQLAEQ- 718

Query: 75  LERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARL--QAALAERRRGLQ 132
            ER    ERL +A   LQ  +K +      L    L++  E   +   Q  LAER+   +
Sbjct: 719 -ERRREQERL-QAERELQEREKALR-----LQKEQLQRELEEKKKKEEQQRLAERQLQEE 771

Query: 133 PKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGP 180
            +K+ A +  G   A +  VD      PA  S Q +P   +A   + P
Sbjct: 772 QEKK-AKEAAGASKALNVTVDVQ---SPACTSYQMTPQGHRAPPKINP 815



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 38/134 (28%), Positives = 63/134 (47%), Gaps = 6/134 (4%)

Query: 2   ESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFV 61
           E     AAA +  ++E++R       RL+  +QE   E ERR Q+   ++ E+E      
Sbjct: 617 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE---EEERRHQELLQKKKEEEQERLRK 673

Query: 62  ATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQ 121
           A  A+ R A +   ER E  ER E+     +  ++   +    LA  + R+ QE L + +
Sbjct: 674 AAEAK-RLAEQREQERREQ-ERREQERREQERREQERREQERQLAEQERRREQERL-QAE 730

Query: 122 AALAERRRGLQPKK 135
             L ER + L+ +K
Sbjct: 731 RELQEREKALRLQK 744


>gi|19913396 smoothelin isoform b [Homo sapiens]
          Length = 915

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 25/80 (31%), Positives = 40/80 (50%)

Query: 13  TGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVE 72
           T D+  +R +      LQR+E ER+ E    K+ R  ++  KEN        A +RAA+ 
Sbjct: 21  TADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQDNKENWLHSQQREAEQRAALA 80

Query: 73  ELLERAESVERLEEAASRLQ 92
            L  + ES+  +EE  + L+
Sbjct: 81  RLAGQLESMNDVEELTALLR 100


>gi|19913394 smoothelin isoform c [Homo sapiens]
          Length = 917

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 25/80 (31%), Positives = 40/80 (50%)

Query: 13  TGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVE 72
           T D+  +R +      LQR+E ER+ E    K+ R  ++  KEN        A +RAA+ 
Sbjct: 21  TADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQDNKENWLHSQQREAEQRAALA 80

Query: 73  ELLERAESVERLEEAASRLQ 92
            L  + ES+  +EE  + L+
Sbjct: 81  RLAGQLESMNDVEELTALLR 100


>gi|19913398 smoothelin isoform a [Homo sapiens]
          Length = 940

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 25/80 (31%), Positives = 40/80 (50%)

Query: 13  TGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVE 72
           T D+  +R +      LQR+E ER+ E    K+ R  ++  KEN        A +RAA+ 
Sbjct: 21  TADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQDNKENWLHSQQREAEQRAALA 80

Query: 73  ELLERAESVERLEEAASRLQ 92
            L  + ES+  +EE  + L+
Sbjct: 81  RLAGQLESMNDVEELTALLR 100


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 30  QRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEEAAS 89
           +++EQ R+LE ++R++K   ++ E+E    +     RE        E+     +LEE   
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456

Query: 90  RLQGLQKLINDSVFFLAAYDLRQ--GQEALARLQAALAERR 128
           +L+ LQ+ +      L  Y  +Q   Q    RLQ  L + R
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQER 497


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 30  QRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEEAAS 89
           +++EQ R+LE ++R++K   ++ E+E    +     RE        E+     +LEE   
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456

Query: 90  RLQGLQKLINDSVFFLAAYDLRQ--GQEALARLQAALAERR 128
           +L+ LQ+ +      L  Y  +Q   Q    RLQ  L + R
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQER 497


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 30  QRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEEAAS 89
           +++EQ R+LE ++R++K   ++ E+E    +     RE        E+     +LEE   
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456

Query: 90  RLQGLQKLINDSVFFLAAYDLRQ--GQEALARLQAALAERR 128
           +L+ LQ+ +      L  Y  +Q   Q    RLQ  L + R
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQER 497


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 30  QRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEEAAS 89
           +++EQ R+LE ++R++K   ++ E+E    +     RE        E+     +LEE   
Sbjct: 397 EQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQR 456

Query: 90  RLQGLQKLINDSVFFLAAYDLRQ--GQEALARLQAALAERR 128
           +L+ LQ+ +      L  Y  +Q   Q    RLQ  L + R
Sbjct: 457 QLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQER 497


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 37.7 bits (86), Expect = 0.015
 Identities = 22/90 (24%), Positives = 45/90 (50%), Gaps = 7/90 (7%)

Query: 7   SAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFAR 66
           S   +R  + E +R+     E+ Q +E+E++ E +R +Q+ + +E+EKE          +
Sbjct: 500 SPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQE-------KQ 552

Query: 67  ERAAVEELLERAESVERLEEAASRLQGLQK 96
                E   E+ + +ER +E    LQ +++
Sbjct: 553 REMEKERKQEKEKELERQKEKEKELQKMKE 582



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 18/74 (24%), Positives = 38/74 (51%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAV 71
           R  ++E +++     ER + RE++++ E E  K++ + +E+EKE          R++   
Sbjct: 515 REKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKE 574

Query: 72  EELLERAESVERLE 85
           +EL +  E  +  E
Sbjct: 575 KELQKMKEQEKECE 588



 Score = 32.0 bits (71), Expect = 0.84
 Identities = 18/75 (24%), Positives = 39/75 (52%), Gaps = 8/75 (10%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAV 71
           + G +E Q     + ER + +E+ER+ E+E+ +++ + +E EK+          R++   
Sbjct: 491 KLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRE--------RQQEKE 542

Query: 72  EELLERAESVERLEE 86
           +EL +  E    +E+
Sbjct: 543 KELEKEQEKQREMEK 557



 Score = 31.2 bits (69), Expect = 1.4
 Identities = 20/87 (22%), Positives = 43/87 (49%), Gaps = 2/87 (2%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAV 71
           R  + E  R+     E+   +EQE+Q E+E+ +++ + +E+E++          +E+   
Sbjct: 527 REKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKE 586

Query: 72  EELLERAESVERLEEAASRLQGLQKLI 98
            EL +  E +E  E+   R   L+ ++
Sbjct: 587 CELEKEREKLE--EKIEPREPNLEPMV 611


>gi|116488398 keratin 32 [Homo sapiens]
          Length = 448

 Score = 37.4 bits (85), Expect = 0.020
 Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 6/71 (8%)

Query: 184 CGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLR-LTKAHSCKLLCGPVST 242
           C  +N+E+Q+ E RA +L +++     L +   RL G  NT R L +   CKL C P ST
Sbjct: 356 CMITNVEAQLAEIRA-DLERQNQEYQVLLDVRARLEGEINTYRSLLENEDCKLPCNPCST 414

Query: 243 SVFLEDCSDCV 253
                 C+ CV
Sbjct: 415 ----PSCTTCV 421


>gi|197333879 genetic suppressor element 1 isoform 2 [Homo sapiens]
          Length = 1113

 Score = 37.4 bits (85), Expect = 0.020
 Identities = 25/79 (31%), Positives = 41/79 (51%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E +R+     ER   RE+E++ E ER K++ Q +E E+E          RE+ A E+ L 
Sbjct: 236 EREREREREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELL 295

Query: 77  RAESVERLEEAASRLQGLQ 95
            A+++E      + L GL+
Sbjct: 296 AAKALEPSFLPVAELHGLR 314



 Score = 35.0 bits (79), Expect = 0.099
 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 8/80 (10%)

Query: 16  MESQRDLSLVPERLQ-----RREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAA 70
           + S+R   L  ERLQ     RRE+ER+ E ER ++  + +E E+E          +ER  
Sbjct: 214 LHSERMSGLSAERLQMDEELRREREREREREREREADREREKEREREREKEREQEKER-- 271

Query: 71  VEELLERAESVERLEEAASR 90
            E   ER   +ER  E  +R
Sbjct: 272 -EREKERERELERQREQRAR 290



 Score = 34.3 bits (77), Expect = 0.17
 Identities = 21/73 (28%), Positives = 35/73 (47%)

Query: 16  MESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELL 75
           ++   +L    ER + RE+ER+ + ER K++ + +E E+E          RER    +  
Sbjct: 227 LQMDEELRREREREREREREREADREREKEREREREKEREQEKEREREKERERELERQRE 286

Query: 76  ERAESVERLEEAA 88
           +RA   E L   A
Sbjct: 287 QRAREKELLAAKA 299


>gi|44955926 genetic suppressor element 1 isoform 1 [Homo sapiens]
          Length = 1217

 Score = 37.4 bits (85), Expect = 0.020
 Identities = 25/79 (31%), Positives = 41/79 (51%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E +R+     ER   RE+E++ E ER K++ Q +E E+E          RE+ A E+ L 
Sbjct: 340 EREREREREREREADREREKEREREREKEREQEKEREREKERERELERQREQRAREKELL 399

Query: 77  RAESVERLEEAASRLQGLQ 95
            A+++E      + L GL+
Sbjct: 400 AAKALEPSFLPVAELHGLR 418



 Score = 35.0 bits (79), Expect = 0.099
 Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 8/80 (10%)

Query: 16  MESQRDLSLVPERLQ-----RREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAA 70
           + S+R   L  ERLQ     RRE+ER+ E ER ++  + +E E+E          +ER  
Sbjct: 318 LHSERMSGLSAERLQMDEELRREREREREREREREADREREKEREREREKEREQEKER-- 375

Query: 71  VEELLERAESVERLEEAASR 90
            E   ER   +ER  E  +R
Sbjct: 376 -EREKERERELERQREQRAR 394



 Score = 34.3 bits (77), Expect = 0.17
 Identities = 21/73 (28%), Positives = 35/73 (47%)

Query: 16  MESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELL 75
           ++   +L    ER + RE+ER+ + ER K++ + +E E+E          RER    +  
Sbjct: 331 LQMDEELRREREREREREREREADREREKEREREREKEREQEKEREREKERERELERQRE 390

Query: 76  ERAESVERLEEAA 88
           +RA   E L   A
Sbjct: 391 QRAREKELLAAKA 403


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 37.0 bits (84), Expect = 0.026
 Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 7/66 (10%)

Query: 27  ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE 86
           E L+R E+ R+ E ERRKQ+   ++ E+E      A +ARE    +  LE  E+  R+EE
Sbjct: 812 EALRRLEERRREEEERRKQEELLRKQEEE-----AAKWAREEEEAQRRLE--ENRLRMEE 864

Query: 87  AASRLQ 92
            A+RL+
Sbjct: 865 EAARLR 870



 Score = 33.9 bits (76), Expect = 0.22
 Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 7/106 (6%)

Query: 27  ERLQRREQERQLEVERRKQ---KRQNQEVEKENSHFFVATFARERAAVEELLERAESVER 83
           E L RR+QE  L  +R ++   +RQ +E E++     +      R   EE  ++ E + +
Sbjct: 777 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 836

Query: 84  LEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
            EE A++    ++   ++   L    LR  +EA ARL+    ER+R
Sbjct: 837 QEEEAAKWAREEE---EAQRRLEENRLRMEEEA-ARLRHEEEERKR 878



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 31/123 (25%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E+QR L     RL+  E+  +L  E  ++KR+  EV+++          R+R   +E L 
Sbjct: 850 EAQRRLE--ENRLRMEEEAARLRHEEEERKRKELEVQRQKE------LMRQRQQQQEALR 901

Query: 77  RAESVERLEEAASRLQGLQKLINDSVFFLAAYDL---RQGQEALARLQAALAERRRGLQP 133
           R +  ++ ++ A       KL + S +   +       Q   +LA +Q    ER R L+ 
Sbjct: 902 RLQQQQQQQQLAQ-----MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 956

Query: 134 KKR 136
           ++R
Sbjct: 957 EQR 959



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 30/125 (24%), Positives = 60/125 (48%), Gaps = 22/125 (17%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAV 71
           +   +E +R  + +  + +  E++RQ E+ R++++   ++ E+E         AR +   
Sbjct: 727 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ-- 784

Query: 72  EELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGL 131
           EE L R    +R +E A R Q  ++            + +Q +EAL RL+    ERRR  
Sbjct: 785 EEALRR----QREQEIALRRQREEE------------ERQQQEEALRRLE----ERRREE 824

Query: 132 QPKKR 136
           + +++
Sbjct: 825 EERRK 829



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 7/87 (8%)

Query: 17   ESQRDLSLVPERLQRREQERQLEVERRKQKR------QNQEVEKENSHFFVATFARERAA 70
            +SQ  LSL   +    E+ERQL  E+R+Q+R      Q Q+ +++         ++    
Sbjct: 933  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992

Query: 71   VEELLE-RAESVERLEEAASRLQGLQK 96
             + LLE + E   ++++   + Q  Q+
Sbjct: 993  TKSLLEIQQEEARQMQKQQQQQQQHQQ 1019


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 37.0 bits (84), Expect = 0.026
 Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 7/66 (10%)

Query: 27  ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE 86
           E L+R E+ R+ E ERRKQ+   ++ E+E      A +ARE    +  LE  E+  R+EE
Sbjct: 839 EALRRLEERRREEEERRKQEELLRKQEEE-----AAKWAREEEEAQRRLE--ENRLRMEE 891

Query: 87  AASRLQ 92
            A+RL+
Sbjct: 892 EAARLR 897



 Score = 33.9 bits (76), Expect = 0.22
 Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 7/106 (6%)

Query: 27  ERLQRREQERQLEVERRKQ---KRQNQEVEKENSHFFVATFARERAAVEELLERAESVER 83
           E L RR+QE  L  +R ++   +RQ +E E++     +      R   EE  ++ E + +
Sbjct: 804 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 863

Query: 84  LEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
            EE A++    ++   ++   L    LR  +EA ARL+    ER+R
Sbjct: 864 QEEEAAKWAREEE---EAQRRLEENRLRMEEEA-ARLRHEEEERKR 905



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 31/123 (25%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E+QR L     RL+  E+  +L  E  ++KR+  EV+++          R+R   +E L 
Sbjct: 877 EAQRRLE--ENRLRMEEEAARLRHEEEERKRKELEVQRQKE------LMRQRQQQQEALR 928

Query: 77  RAESVERLEEAASRLQGLQKLINDSVFFLAAYDL---RQGQEALARLQAALAERRRGLQP 133
           R +  ++ ++ A       KL + S +   +       Q   +LA +Q    ER R L+ 
Sbjct: 929 RLQQQQQQQQLAQ-----MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 983

Query: 134 KKR 136
           ++R
Sbjct: 984 EQR 986



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 30/125 (24%), Positives = 60/125 (48%), Gaps = 22/125 (17%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAV 71
           +   +E +R  + +  + +  E++RQ E+ R++++   ++ E+E         AR +   
Sbjct: 754 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ-- 811

Query: 72  EELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGL 131
           EE L R    +R +E A R Q  ++            + +Q +EAL RL+    ERRR  
Sbjct: 812 EEALRR----QREQEIALRRQREEE------------ERQQQEEALRRLE----ERRREE 851

Query: 132 QPKKR 136
           + +++
Sbjct: 852 EERRK 856



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 7/87 (8%)

Query: 17   ESQRDLSLVPERLQRREQERQLEVERRKQKR------QNQEVEKENSHFFVATFARERAA 70
            +SQ  LSL   +    E+ERQL  E+R+Q+R      Q Q+ +++         ++    
Sbjct: 960  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019

Query: 71   VEELLE-RAESVERLEEAASRLQGLQK 96
             + LLE + E   ++++   + Q  Q+
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQ 1046


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 37.0 bits (84), Expect = 0.026
 Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 7/66 (10%)

Query: 27  ERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEE 86
           E L+R E+ R+ E ERRKQ+   ++ E+E      A +ARE    +  LE  E+  R+EE
Sbjct: 818 EALRRLEERRREEEERRKQEELLRKQEEE-----AAKWAREEEEAQRRLE--ENRLRMEE 870

Query: 87  AASRLQ 92
            A+RL+
Sbjct: 871 EAARLR 876



 Score = 33.9 bits (76), Expect = 0.22
 Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 7/106 (6%)

Query: 27  ERLQRREQERQLEVERRKQ---KRQNQEVEKENSHFFVATFARERAAVEELLERAESVER 83
           E L RR+QE  L  +R ++   +RQ +E E++     +      R   EE  ++ E + +
Sbjct: 783 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRK 842

Query: 84  LEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRR 129
            EE A++    ++   ++   L    LR  +EA ARL+    ER+R
Sbjct: 843 QEEEAAKWAREEE---EAQRRLEENRLRMEEEA-ARLRHEEEERKR 884



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 31/123 (25%), Positives = 56/123 (45%), Gaps = 16/123 (13%)

Query: 17  ESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLE 76
           E+QR L     RL+  E+  +L  E  ++KR+  EV+++          R+R   +E L 
Sbjct: 856 EAQRRLE--ENRLRMEEEAARLRHEEEERKRKELEVQRQKE------LMRQRQQQQEALR 907

Query: 77  RAESVERLEEAASRLQGLQKLINDSVFFLAAYDL---RQGQEALARLQAALAERRRGLQP 133
           R +  ++ ++ A       KL + S +   +       Q   +LA +Q    ER R L+ 
Sbjct: 908 RLQQQQQQQQLAQ-----MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLRE 962

Query: 134 KKR 136
           ++R
Sbjct: 963 EQR 965



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 30/125 (24%), Positives = 60/125 (48%), Gaps = 22/125 (17%)

Query: 12  RTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAV 71
           +   +E +R  + +  + +  E++RQ E+ R++++   ++ E+E         AR +   
Sbjct: 733 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQ-- 790

Query: 72  EELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGL 131
           EE L R    +R +E A R Q  ++            + +Q +EAL RL+    ERRR  
Sbjct: 791 EEALRR----QREQEIALRRQREEE------------ERQQQEEALRRLE----ERRREE 830

Query: 132 QPKKR 136
           + +++
Sbjct: 831 EERRK 835



 Score = 29.3 bits (64), Expect = 5.4
 Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 7/87 (8%)

Query: 17   ESQRDLSLVPERLQRREQERQLEVERRKQKR------QNQEVEKENSHFFVATFARERAA 70
            +SQ  LSL   +    E+ERQL  E+R+Q+R      Q Q+ +++         ++    
Sbjct: 939  QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998

Query: 71   VEELLE-RAESVERLEEAASRLQGLQK 96
             + LLE + E   ++++   + Q  Q+
Sbjct: 999  TKSLLEIQQEEARQMQKQQQQQQQHQQ 1025


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.130    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,630,329
Number of Sequences: 37866
Number of extensions: 546316
Number of successful extensions: 5630
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 301
Number of HSP's that attempted gapping in prelim test: 3826
Number of HSP's gapped (non-prelim): 1491
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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